Dr. William  K.K. Wu

Dr. William K.K. Wu

Assistant Professor
Chinese University of Hong Kong, China


Highest Degree
Ph.D. in Medical Science from The Chinese University of Hong Kong, China

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Area of Interest:

Biomedical Sciences
100%
Cellular Signalling
62%
Gastrointestinal Cancers
90%
Ubiquitin-Proteasome System
75%
Cancer Genomics
55%

Education

2006

Ph.D.

The Chinese University of Hong Kong, China

Medical Science

Selected Publications

  1. Zhang, L., J. Yu, C.C.M. Wong, T.K.W. Ling and Z.J. Li et al., 2013. Cathelicidin protects against Helicobacter pylori colonization and the associated gastritis in mice. Gene. Ther., 20: 751-760.
    PubMed  |  

  2. Wu, W.K.K., X.J. Wang, A.S.L. Cheng and M.X.M. Luo et al., 2013. Dysregulation and crosstalk of cellular signaling pathways in colon carcinogenesis. Crit. Rev. Oncol. Hematol., 86: 251-277.
    CrossRef  |  PubMed  |  

  3. Wong, X.J., J. Yu, S.H. Wong, A.S.L. Cheng and F.K.L. Chan et al., 2013. A novel crosstalk between two major protein degradation systems: Regulation of proteasomal activity by autophagy. Autophagy, 9: 1500-1508.
    PubMed  |  

  4. Wang, L., J.H. Yeung, T. Hu, W.Y. Lee and L. Lu et al., 2013. Dihydrotanshinone induces p53 independent but ROS dependent apoptosis in colon cancer cells. Life Sci., 93: 344-351.
    PubMed  |  Direct Link  |  

  5. Tai, E.K.K., W.K.K. Wu, X.J. Wang, H.P.S. Wong and L. Yu et al., 2013. Intrarectal administration of mCRAMP-encoding plasmid reverses exacerbated colitis in Cnlp(-/-) mice. Gene. Ther., 20: 187-193.
    CrossRef  |  PubMed  |  

  6. Shen, J., W.K. Wu, S.X. Ren, L. Zhang and R.L. Chan et al., 2013. miRNAs in gastrointestinal and liver cancers: Their perspectives and clinical applications. Curr. Pharm. Des., 19: 1301-1310.
    PubMed  |  

  7. Li, Z., J. Shen, W.K. Wu, X. Yu, J. Liang, G. Qiu and J. Liu, 2013. The role of leptin on the organization and expression of cytoskeleton elements in nucleus pulposus cells. J. Orthop. Res., 31: 847-857.
    PubMed  |  

  8. Chow, J.Y.C., Z.J. Li, W.K. Wu and C.H. Cho, 2013. Cathelicidin a potential therapeutic peptide for gastrointestinal inflammation and cancer. World J. Gastroenterol., 19: 2731-2735.
    PubMed  |  

  9. Zhang, L., J.W. Ren, C.C.M. Wong, W.K. Wu and S.X. Ren et al., 2012. Effects of cigarette smoke and its active components on ulcer formation and healing in the gastrointestinal mucosa. Curr. Med. Chem., 19: 63-69.
    PubMed  |  

  10. Wu, Y.C., X.J. Wang, L. Yu, F.K.L. Chan and A.S.L. Cheng et al., 2012. Hydrogen sulfide lowers proliferation and induces protective autophagy in colon epithelial cells. PLoS ONE, Vol. 7. .
    PubMed  |  

  11. Wu, W.K.K., S.B. Coffelt, C.H. Cho, X.J. Wang and C.W. Lee et al., 2012. The autophagic paradox in cancer therapy. Oncogene, 31: 939-953.
    PubMed  |  

  12. Wu W.K. and J.J.Y. Sung, 2012. MicroRNA dysregulations in gastrointestinal Cancers: Pathophysiological and clinical perspectives. Intest. Res., 10: 324-331.

  13. Wong, C.C.M., L. Zhang, Z.J. Li, W.K. Wu and S.X. Ren et al., 2012. Protective effects of cathelicidin-encoding Lactococcus lactis in murine ulcerative colitis. J. Gastroenterol. Hepatol., 27: 1205-1212.
    CrossRef  |  PubMed  |  

  14. Ren, S.X., A.S.L. Cheng, K.F. To, J.H.M. Tong and M.S. Li et al., 2012. Host immune defense peptide LL-37 activates caspase-independent apoptosis and suppresses colon cancer. Cancer Res., 72: 6512-6523.
    CrossRef  |  PubMed  |  

  15. Liu, Y., F. Song, W.K. Wu, M. He and L. Zhao et al., 2012. Triptolide inhibits colon cancer cell proliferation and induces cleavage and translocation of 14-3-3 epsilon. Cell. Biochem. Funct., 30: 271-278.
    PubMed  |  

  16. Feng, S.Y., C.G. Dong, W.K. Wu, X.J. Wang, J. Qiao and J.F. Shao, 2012. Lentiviral expression of anti-microRNAs targeting miR- 27a inhibits proliferation and invasiveness of U87 glioma cells. Mol. Med. Report., 6: 275-281.
    PubMed  |  

  17. Fan, Q., M. He, X. Deng, W.K. Wu and L. Zhao et al., 2012. Derepression of c-Fos caused by MicroRNA-139 down-regulation contributes to the metastasis of human hepatocellular carcinoma. Cell. Biochem. Funct., 30: 271-278.
    PubMed  |  

  18. Dong, C.G., W.K. Wu, S.Y. Feng, X.J. Wang, J.F. Shao and J. Qiao, 2012. Co-inhibition of microRNA-10b and microRNA-21 exerts synergistic inhibition on the proliferation and invasion of human glioma cells. Int. J. Oncol., 41: 1005-1012.
    PubMed  |  

  19. Ye, C.G., W.K. Wu, J.H.K. Yeung, H.T. Li and Z.J. Li et al., 2011. Indomethacin and SC236 enhance the cytotoxicity of doxorubicin in human hepatocellular carcinoma cells via inhibiting P-glycoprotein and MRP1 expression. Cancer Lett., 304: 90-96.
    PubMed  |  

  20. Wu, W.K., P.T. Law, C.W. Lee, C.H. Cho and D. Fan et al., 2011. MicroRNA in colorectal cancer: From benchtop to bedside. Carcinogenesis, 32: 247-253.
    PubMed  |  

  21. Wong, H.P., J.W. Ho, M.W. Koo, L. Yu and W.K. Wu et al., 2011. Effects of adrenaline in human colon adenocarcinoma HT-29 cells. Life Sci., 88: 1108-1112.
    CrossRef  |  PubMed  |  

  22. Liang, J., J. Feng, W.K. Wu, Z. Wu, D. Han, Y. Zhu and G. Qiu, 2011. Leptin-mediated cytoskeletal remodeling in chondrocytes via the RhoA/ROCK pathway. J. Orthop. Res., 29: 369-374.
    PubMed  |  

  23. Li, Z.J., W.K. Wu, S.S. Ng, L. Yu and H.T. Li et al., 2011. A novel peptide specifically targeting the vasculature of orthotopic colorectal cancer for imaging detection and drug delivery. J. Control Release, 148: 292-302.
    PubMed  |  

  24. Li, X., Y. Zhao, W.K. Wu, S. Liu, M. Cui and H. Lou, 2011. Solamargine induces apoptosis associated with p53 transcription- dependent and transcription-independent pathways in human osteosarcoma U2OS cells. Life Sci., 88: 314-321.
    PubMed  |  

  25. Li, X., W.K. Wu, B. Sun, M. Cui, S. Liu, J. Gao and H. Lou, 2011. Dihydroptychantol A, a macrocyclic bisbibenzyl derivative, induces autophagy and following apoptosis associated with p53 pathway in human osteosarcoma U2OS cells. Toxicol. Appl. Pharmacol., 251: 146-154.
    PubMed  |  

  26. Dong, Y., W.K.K. Wu, C.W. Wu, J.J. Sung, J. Yu and S.S.M. Ng, 2011. MicroRNA dysregulation in colorectal cancer: A clinical perspective. Br. J. Cancer, 104: 893-898.
    CrossRef  |  

  27. Yu, J., X. Ma, K.F. Cheung, X. Li and L. Tian et al., 2010. Epigenetic inactivation of T-box transcription factor 5, a novel tumor suppressor gene, is associated with colon cancer. Oncogene, 29: 6464-6474.
    PubMed  |  

  28. Wu, W.K.K., C.W. Lee, C.H. Cho, D. Fan, K. Wu, J. Yu and J.J.Y. Sung, 2010. MicroRNA dysregulation in gastric cancer: A new player enters the game. Oncogene, 29: 5761-5771.
    CrossRef  |  

  29. Wu, W.K., J.J. Sung, K.F. To, L. Yu and H.T. Li et al., 2010. The host defense peptide LL-37 activates the tumor-suppressing bone morphogenetic protein signaling via inhibition of proteasome in gastric cancer cells. J. Cell Physiol., 223: 178-186.
    PubMed  |  

  30. Wu, W.K., J.J. Sung, C.W. Lee, J. Yu and C.H. Cho, 2010. Cyclooxygenase-2 in tumorigenesis of gastrointestinal cancers: An update on the molecular mechanism. Cancer Lett., 295: 7-16.
    PubMed  |  

  31. Wu, W.K., G. Wang, S.B. Coffelt, A.M. Betancourt and C.W. Lee et al., 2010. Emerging roles of the host defense peptide LL-37 in human cancer and its potential therapeutic applications. Int. J. Cancer, 127: 1741-1747.
    PubMed  |  

  32. Wu, W.K., C.H. Cho, C.W. Lee, Y.C. Wu and L. Yu et al., 2010. Macroautophagy and ERK phosphorylation counteract the antiproliferative effect of proteasome inhibitor in gastric cancer cells. Autophagy, 6: 228-238.
    PubMed  |  

  33. Wu, W.K., C.H. Cho, C.W. Lee, K. Wu, D. Fan, J. Yu and J.J. Sung, 2010. Proteasome inhibition: A new therapeutic strategy to cancer treatment. Cancer Lett., 293: 15-22.
    PubMed  |  

  34. Wu, W.K., C.H. Cho, C.W. Lee, D. Fan, K. Wu, J. Yu and J.J. Sung, 2010. Dysregulation of cellular signaling in gastric cancer. Cancer Lett., 295: 144-153.
    PubMed  |  

  35. Wu, W.K., C.H. Cho, C.W. Lee, D. Fan, K. Wu, J. Yu and J.J. Sung, 2010. Dysregulation of cellular signaling in gastric cancer. Cancer Lett., 295: 144-153.
    PubMed  |  

  36. Wu, W.K., C.C. Wong, Z.J. Li, L. Zhang, S.X. Ren and C.H. Cho, 2010. Cathelicidins in inflammation and tissue repair: Potential therapeutic applications for gastrointestinal disorders. Act. Pharmacol. Sin., 31: 1118-1122.
    PubMed  |  

  37. Tang, J., Y. Sun, W.K. Wu, T. Zhong and Y. Liu et al., 2010. Propofol lowers serum PF4 level and partially corrects hypercoagulopathy in endotoxemic rats. Biochim. Biophys. Act - Proteins Proteomics, 1804: 1895-1901.
    PubMed  |  

  38. Olaleye, S.B., S.A. Onasanwo, A.O. Ige, K.K. Wu and C.H. Cho, 2010. Anti-inflammatory activities of a kolaviron-inhibition of nitric oxide, prostaglandin E2 and tumor necrosis factor-alpha production in activated macrophage-like cell line. Afr. J. Med. Med. Sci., 39: 41-46.
    PubMed  |  

  39. Olaleye, S.B., K.K. Wu and C.H. Cho, 2010. Catecholamines inhibit gastric epithelial [RGM-1] cell proliferation via beta adrenoceptors. Niger. J. Physiol. Sci., 25: 5-16.
    PubMed  |  

  40. Li, H., W.K. Wu, Z.J. Li, K.M. Chan and C.C.M. Wong et al., 2010. 2,3',4,4',5'-Pentamethoxy- trans-stilbene, a resveratrol derivative, inhibits colitis-associated colorectal carcinogenesis in mice. Br. J. Pharmacol., 16: 1352-1361.

  41. Li, H., W.K. Wu, Z. Zheng, C.T. Che and Z.J. Li et al., 2010. 3,3',4,5,5'- Pentahydroxy-trans-stilbene, a resveratrol derivative, induces apoptosis in colorectal carcinoma cells via oxidative stress. Eur. J. Pharmacol., 637: 55-61.

  42. Wu, W.K.K., K.M. Sakamoto, M. Milani, G. Aldana-Masankgay and D. Fan et al., 2010. Macroautophagy modulates cellular response to proteasome inhibitors in cancer therapy. Drug Resist Update, 13: 87-92.
    CrossRef  |  

  43. Wu, Y.C., W.K. Wu, Y. Li, L. Yu and Z.J. Li et al., 2009. Inhibition of macroautophagy by bafilomycin A1 lowers proliferation and induces apoptosis in colon cancer cells. Biochem. Biophys. Res. Commun., 382: 541-546.
    PubMed  |  

  44. Wu, W.K., V. Volta, C.H. Cho, Y.C. Wu and H.T. Li et al., 2009. Repression of protein translation and mTOR signaling by proteasome inhibitor in colon cancer cells. Biochem. Biophys. Res. Commun., 386: 598-601.
    CrossRef  |  Direct Link  |  

  45. Wu, W.K., T.T. Tse, J.J. Sung, Z.J. Li, L. Yu and C.H. Cho, 2009. Expression of ErbB receptors and their cognate ligands in gastric and colon cancer cell lines. Anticancer Res., 29: 229-234.
    PubMed  |  

  46. Wu, W.K., J.J.Y. Sung, Y.C. Wu, H.T. Li, L. Yu, Z.J. Li and C.H. Cho, 2009. Inhibition of cyclooxygenase-1 lowers proliferation and induces macroautophagy in colon cancer cells. Biochem. Biophys. Res. Commun., 382: 79-84.
    PubMed  |  Direct Link  |  

  47. Wu, W.K., Y.C. Wu, L. Yu, Z.J. Li, J.J.Y. Sung and C.H. Cho, 2008. Induction of autophagy by proteasome inhibitor is associated with proliferative arrest in colon cancer cells. Biochem. Biophys. Res. Commun., 374: 258-263.
    PubMed  |  

  48. Wu, W.K., J.J.Y. Sung, Y.C. Wu, Z.J. Li, L. Yu and C.H. Cho, 2008. Bone morphogenetic protein signalling is required for the anti-mitogenic effect of the proteasome inhibitor MG-132 on colon cancer cells. Br. J. Pharmacol., 154: 632-638.
    PubMed  |  

  49. Wu, W.K., J.J.Y. Sung, L. Yu, Z.J. Li, K.M. Chu and C.H. Cho, 2008. Constitutive hypophosphorylation of extracellular signal- regulated kinases-1/2 and down-regulation of c-Jun in human gastric adenocarcinoma. Biochem. Biophys. Res. Commun., 373: 330-334.
    PubMed  |  

  50. Wu, W.K., J.J.Y. Sung, L. Yu and C.H. Cho, 2008. Proteasome inhibitor MG-132 lowers gastric adenocarcinoma TMK1 cell proliferation via bone morphogenetic protein signaling. Biochem. Biophys. Res. Commun., 371: 209-214.
    PubMed  |  

  51. Wu, W.K., G.R. Li, T.M. Wong, J.Y. Wang, L. Yu and C.H. Cho, 2008. Involvement of voltage-gated K+ and Na+ channels in gastric epithelial cell migration. Mol. Cell. Biochem., 308: 219-226.
    PubMed  |  

  52. Liu, X., W.K. Wu, L. Yu, Z.J. Li, J.J.Y. Sung, S.T. Zhang and C.H. Cho, 2008. Epidermal growth factor-induced esophageal cancer cell proliferation requires transactivation of beta-adrenoceptors. J. Pharmacol. Exp. Ther., 326: 69-75.
    PubMed  |  

  53. Liu, X., W.K. Wu, L. Yu, J.J.Y. Sung, G. Srivastava, S.T. Zhang and C.H. Cho, 2008. Epinephrine stimulates esophageal squamous-cell carcinoma cell proliferation via beta-adrenoceptor-dependent transactivation of extracellular signal-regulated kinase/cyclooxygenase-2 pathway. J. Cell Biochem., 105: 53-60.
    PubMed  |  

  54. Wu, W.K., P.T. Law, H.P.S. Wong, E.K.Y. Lam, E.K.K. Tai, V.Y. Shin and C.H. Cho, 2007. Shift of homeostasis from parenchymal regeneration to fibroblast proliferation induced by lipopolysaccharide-activated macrophages in gastric mucosal healing in vitro. Wound Repair Regen., 15: 221-226.
    PubMed  |  

  55. Wong, H.P.S., L. Yu, E.K. Lam, E.K.Y. Tai, W.K. Wu and C.H. Cho, 2007. Nicotine promotes colon tumor growth and angiogenesis through beta-adrenergic activation. Toxicol. Sci., 97: 279-287.
    PubMed  |  

  56. Wong, H.P., L. Yu, E.K.Y. Lam, E.K.K. Tai, W.K. Wu and C.H. Cho, 2007. Nicotine promotes cell proliferation via alpha7-nicotinic acetylcholine receptor and catecholamine-synthesizing enzymes-mediated pathway in human colon adenocarcinoma HT-29 cells. Toxicol. Appl. Pharmacol., 221: 261-267.
    PubMed  |  

  57. Tai, E.K.K., W.K. Wu, H.P.S. Wong, E.K.Y. Lam, L. Yu and C.H. Cho, 2007. A new role for cathelicidin in ulcerative colitis in mice. Exp. Biol. Med., 232: 799-808.
    PubMed  |  

  58. Shin, V.Y., W.K. Wu, P.S. Wong, E.K. Lam, E.K. Tai, M.W. Koo and C.H. Cho, 2007. Functional role of β-adrenergic receptors in the mitogenic action of nicotine on gastric cancer cells. Toxicol. Sci., 96: 21-29 .
    PubMed  |  Direct Link  |  

  59. Liu, E.S., Y.N. Ye, V.Y. Shin, W.K. Wu, B.C. Wong and C.H. Cho, 2007. Interaction of cigarette smoking with cyclooxygenase-2 on ulcerative colitis-associated neoplasia in mice. Cancer Invest., 25: 750-757.
    CrossRef  |  Direct Link  |  

  60. Lam, E.K.Y., L. Yu, H.P.S. Wong, W.K.K. Wu and V.Y. Shin et al., 2007. Probiotic Lactobacillus rhamnosus GG enhances gastric ulcer healing in rats. Eur. J. Pharmacol., 565: 171-179.
    CrossRef  |  Direct Link  |  

  61. Lam, E.K., E.K. Tai, M.W. Koo, H.P. Wong and W.K. Wu et al., 2007. Enhancement of gastric mucosal integrity by Lactobacillus rhamnosus GG. Life Sci., 80: 2128-2136.
    CrossRef  |  PubMed  |  

  62. Yang, Y.H., W.K. Wu, E.K. Tai, H.P. Wong and E.K. Lam et al., 2006. The cationic host defense peptide rCRAMP promotes gastric ulcer healing in rats. J. Pharmacol. Exp. Ther., 318: 547-554.
    CrossRef  |  PubMed  |  

  63. Wu, W.K., V.Y. Shin, Y.N. Ye, H.P. Wong and F.Y. Huang et al., 2006. Heparin increases human gastric carcinoma cell growth. Anticancer Res., 26: 439-443.
    PubMed  |  

  64. Wu, W.K., G.R. Li, H.P.S. Wong, M.K.C. Hui and E.K.K. Tai et al., 2006. Involvement of Kv1.1 and Nav1.5 in proliferation of gastric epithelial cells. J. Cell. Physiol., 270: 437-444.
    PubMed  |  

  65. Hui, M.K.C., W.K.K. Wu, V.Y. Shin, W.H.L. So and C.H. Cho, 2006. Polysaccharides from the root of Angelica sinensis protect bone marrow and gastrointestinal tissues against the cytotoxicity of cyclophosphamide in mice. Int. J. Med. Sci., 3: 1-6.
    Direct Link  |  

  66. Ye, Y.N., W.K. Wu, V.Y. Shin, I.C. Bruce, B.C. Wong and C.H. Cho, 2005. Dual inhibition of 5-LOX and COX-2 suppresses colon cancer formation promoted by cigarette smoke. Carcinogenesis, 26: 827-834 .
    PubMed  |  Direct Link  |  

  67. Ye, Y.N., W.K. Wu, V.Y. Shin and C.H. Cho, 2005. A mechanistic study of colon cancer growth promoted by cigarette smoke extract. Eur. J. Pharmacol., 519: 52-57.
    CrossRef  |  Direct Link  |  

  68. Wu, W.K., H.P. Wong, S.W. Luo, K. Chan and F.Y. Huang et al., 2005. 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone from cigarette smoke stimulates colon cancer growth via β-adrenoceptors. Cancer Res., 65: 5272-5277.
    PubMed  |  

  69. Shin, V.Y., W.K. Wu, K.M. Chu, H.P. Wong and E.K. Lam et al., 2005. Nicotine induces cyclooxygenase-2 and vascular endothelial growth factor receptor-2 in association with tumor-associated invasion and angiogenesis in gastric cancer. Mol. Cancer Res., 3: 607-615.
    PubMed  |  Direct Link  |  

  70. Luo, J.C., V.Y. Shin, Y.H. Yang, W.K. Wu and Y.N. Ye et al., 2005. Tumor necrosis factor-alpha stimulates gastric epithelial cell proliferation. Am. J. Physiol. Gastrointest. Liver Physiol., 288: G32-G38.
    PubMed  |  Direct Link  |  

  71. Liu, E.S., V.Y. Shin, Y.N. Ye, J.C. Luo, W.K. Wu and C.H. Cho, 2005. Cyclooxygenase-2 in cancer cells and macrophages induces colon cancer cell growth by cigarette smoke extract. Eur. J. Pharmacol., 518: 47-55.
    CrossRef  |  Direct Link  |  

  72. Ye, Y.N., E.S. Liu, V.Y. Shin, W.K. Wu, J.C. Luo and C.H. Cho, 2004. Nicotine promoted colon cancer growth via epidermal growth factor receptor, c-Src and 5-lipoxygenase-mediated signal pathway. J. Pharmacol. Exp. Ther., 308: 66-72.
    PubMed  |  Direct Link  |  

  73. Ye, Y.N., E.S. Liu, V.Y. Shin, W.K. Wu and C.H. Cho, 2004. The modulating role of nuclear factor-kappaB in the action of alpha7-nicotinic acetylcholine receptor and cross-talk between 5-lipoxygenase and cyclooxygenase-2 in colon cancer growth induced by 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone. J. Pharmacol. Exp. Ther., 311: 123-130.
    PubMed  |  Direct Link  |  

  74. Ye, Y.N., E.S. Liu, V.Y. Shin, W.K. Wu and C.H. Cho, 2004. Contributory role of 5-lipoxygenase and its association with angiogenesis in the promotion of inflammation-associated colonic tumorigenesis by cigarette smoking. Toxicology, 203: 179-188.
    PubMed  |  Direct Link  |  

  75. Wu, W.K. and C.H. Cho, 2004. The pharmacological actions of nicotine on the gastrointestinal tract. J. Pharmacol. Sci., 94: 348-358.
    PubMed  |  

  76. Shin, V.Y., W.K. Wu, Y.N. Ye, W.H. So and Koo MW et al., 2004. Nicotine promotes gastric tumor growth and neovascularization by activating extracellular signal-regulated kinase and cyclooxygenase-2. Carcinogenesis, 25: 2487-2495.
    PubMed  |  Direct Link  |  

  77. Luo, J.C., V.Y. Shin, E.S. Liu, Y.N. Ye, W.K. Wu, F.Y. Chang and C.H. Cho, 2004. Dexamethasone delays ulcer healing by inhibition of angiogenesis in rat stomachs. Eur. J. Pharmacol., 485: 275-281.
    CrossRef  |  Direct Link  |  

  78. Cho, C.H., K.K. Wu, S. Wu, T.M. Wong and W.H. So et al., 2003. Morphine as a drug for stress ulcer prevention and healing in the stomach. Eur. J. Pharmacol., 460: 177-182.
    PubMed  |  Direct Link  |