Hi, I am William K.K. Wu, My LiveDNA is 86.5976
 
   
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Dr. William K.K. Wu
 
Highest Degree: Ph.D. in Medical Science from The Chinese University of Hong Kong, China
 
Institute: The Chinese University of Hong Kong, Hong Kong
 
Area of Interest: Biomedical Sciences
  •   Cellular Signalling
  •   Gastrointestinal Cancers
  •   Ubiquitin-Proteasome System
  •   Cancer Genomics
 
URL: http://livedna.org/86.5976
 
My SELECTED Publications
1:    Wu, W.K.K., K.M. Sakamoto, M. Milani, G. Aldana-Masankgay and D. Fan et al., 2010. Macroautophagy modulates cellular response to proteasome inhibitors in cancer therapy. Drug Resist Update, 13: 87-92.
CrossRef  |  
2:   Cho, C.H., K.K. Wu, S. Wu, T.M. Wong and W.H. So et al., 2003. Morphine as a drug for stress ulcer prevention and healing in the stomach. Eur. J. Pharmacol., 460: 177-182.
PubMed  |  Direct Link  |  
3:   Chow, J.Y.C., Z.J. Li, W.K. Wu and C.H. Cho, 2013. Cathelicidin a potential therapeutic peptide for gastrointestinal inflammation and cancer. World J. Gastroenterol., 19: 2731-2735.
PubMed  |  
4:   Dong, C.G., W.K. Wu, S.Y. Feng, X.J. Wang, J.F. Shao and J. Qiao, 2012. Co-inhibition of microRNA-10b and microRNA-21 exerts synergistic inhibition on the proliferation and invasion of human glioma cells. Int. J. Oncol., 41: 1005-1012.
PubMed  |  
5:   Dong, Y., W.K.K. Wu, C.W. Wu, J.J. Sung, J. Yu and S.S.M. Ng, 2011. MicroRNA dysregulation in colorectal cancer: A clinical perspective. Br. J. Cancer, 104: 893-898.
CrossRef  |  
6:   Fan, Q., M. He, X. Deng, W.K. Wu and L. Zhao et al., 2012. Derepression of c-Fos caused by MicroRNA-139 down-regulation contributes to the metastasis of human hepatocellular carcinoma. Cell. Biochem. Funct., 30: 271-278.
PubMed  |  
7:   Feng, S.Y., C.G. Dong, W.K. Wu, X.J. Wang, J. Qiao and J.F. Shao, 2012. Lentiviral expression of anti-microRNAs targeting miR- 27a inhibits proliferation and invasiveness of U87 glioma cells. Mol. Med. Report., 6: 275-281.
PubMed  |  
8:   Hui, M.K.C., W.K.K. Wu, V.Y. Shin, W.H.L. So and C.H. Cho, 2006. Polysaccharides from the root of Angelica sinensis protect bone marrow and gastrointestinal tissues against the cytotoxicity of cyclophosphamide in mice. Int. J. Med. Sci., 3: 1-6.
Direct Link  |  
9:   Lam, E.K., E.K. Tai, M.W. Koo, H.P. Wong and W.K. Wu et al., 2007. Enhancement of gastric mucosal integrity by Lactobacillus rhamnosus GG. Life Sci., 80: 2128-2136.
CrossRef  |  PubMed  |  
10:   Lam, E.K.Y., L. Yu, H.P.S. Wong, W.K.K. Wu and V.Y. Shin et al., 2007. Probiotic Lactobacillus rhamnosus GG enhances gastric ulcer healing in rats. Eur. J. Pharmacol., 565: 171-179.
CrossRef  |  Direct Link  |  
11:   Li, H., W.K. Wu, Z. Zheng, C.T. Che and Z.J. Li et al., 2010. 3,3',4,5,5'- Pentahydroxy-trans-stilbene, a resveratrol derivative, induces apoptosis in colorectal carcinoma cells via oxidative stress. Eur. J. Pharmacol., 637: 55-61.
12:   Li, H., W.K. Wu, Z.J. Li, K.M. Chan and C.C.M. Wong et al., 2010. 2,3',4,4',5'-Pentamethoxy- trans-stilbene, a resveratrol derivative, inhibits colitis-associated colorectal carcinogenesis in mice. Br. J. Pharmacol., 16: 1352-1361.
13:   Li, X., W.K. Wu, B. Sun, M. Cui, S. Liu, J. Gao and H. Lou, 2011. Dihydroptychantol A, a macrocyclic bisbibenzyl derivative, induces autophagy and following apoptosis associated with p53 pathway in human osteosarcoma U2OS cells. Toxicol. Appl. Pharmacol., 251: 146-154.
PubMed  |  
14:   Li, X., Y. Zhao, W.K. Wu, S. Liu, M. Cui and H. Lou, 2011. Solamargine induces apoptosis associated with p53 transcription- dependent and transcription-independent pathways in human osteosarcoma U2OS cells. Life Sci., 88: 314-321.
PubMed  |  
15:   Li, Z., J. Shen, W.K. Wu, X. Yu, J. Liang, G. Qiu and J. Liu, 2013. The role of leptin on the organization and expression of cytoskeleton elements in nucleus pulposus cells. J. Orthop. Res., 31: 847-857.
PubMed  |  
16:   Li, Z.J., W.K. Wu, S.S. Ng, L. Yu and H.T. Li et al., 2011. A novel peptide specifically targeting the vasculature of orthotopic colorectal cancer for imaging detection and drug delivery. J. Control Release, 148: 292-302.
PubMed  |  
17:   Liang, J., J. Feng, W.K. Wu, Z. Wu, D. Han, Y. Zhu and G. Qiu, 2011. Leptin-mediated cytoskeletal remodeling in chondrocytes via the RhoA/ROCK pathway. J. Orthop. Res., 29: 369-374.
PubMed  |  
18:   Liu, E.S., V.Y. Shin, Y.N. Ye, J.C. Luo, W.K. Wu and C.H. Cho, 2005. Cyclooxygenase-2 in cancer cells and macrophages induces colon cancer cell growth by cigarette smoke extract. Eur. J. Pharmacol., 518: 47-55.
CrossRef  |  Direct Link  |  
19:   Liu, E.S., Y.N. Ye, V.Y. Shin, W.K. Wu, B.C. Wong and C.H. Cho, 2007. Interaction of cigarette smoking with cyclooxygenase-2 on ulcerative colitis-associated neoplasia in mice. Cancer Invest., 25: 750-757.
CrossRef  |  Direct Link  |  
20:   Liu, X., W.K. Wu, L. Yu, J.J.Y. Sung, G. Srivastava, S.T. Zhang and C.H. Cho, 2008. Epinephrine stimulates esophageal squamous-cell carcinoma cell proliferation via beta-adrenoceptor-dependent transactivation of extracellular signal-regulated kinase/cyclooxygenase-2 pathway. J. Cell Biochem., 105: 53-60.
PubMed  |  
21:   Liu, X., W.K. Wu, L. Yu, Z.J. Li, J.J.Y. Sung, S.T. Zhang and C.H. Cho, 2008. Epidermal growth factor-induced esophageal cancer cell proliferation requires transactivation of beta-adrenoceptors. J. Pharmacol. Exp. Ther., 326: 69-75.
PubMed  |  
22:   Liu, Y., F. Song, W.K. Wu, M. He and L. Zhao et al., 2012. Triptolide inhibits colon cancer cell proliferation and induces cleavage and translocation of 14-3-3 epsilon. Cell. Biochem. Funct., 30: 271-278.
PubMed  |  
23:   Luo, J.C., V.Y. Shin, E.S. Liu, Y.N. Ye, W.K. Wu, F.Y. Chang and C.H. Cho, 2004. Dexamethasone delays ulcer healing by inhibition of angiogenesis in rat stomachs. Eur. J. Pharmacol., 485: 275-281.
CrossRef  |  Direct Link  |  
24:   Luo, J.C., V.Y. Shin, Y.H. Yang, W.K. Wu and Y.N. Ye et al., 2005. Tumor necrosis factor-alpha stimulates gastric epithelial cell proliferation. Am. J. Physiol. Gastrointest. Liver Physiol., 288: G32-G38.
PubMed  |  Direct Link  |  
25:   Olaleye, S.B., K.K. Wu and C.H. Cho, 2010. Catecholamines inhibit gastric epithelial [RGM-1] cell proliferation via beta adrenoceptors. Niger. J. Physiol. Sci., 25: 5-16.
PubMed  |  
26:   Olaleye, S.B., S.A. Onasanwo, A.O. Ige, K.K. Wu and C.H. Cho, 2010. Anti-inflammatory activities of a kolaviron-inhibition of nitric oxide, prostaglandin E2 and tumor necrosis factor-alpha production in activated macrophage-like cell line. Afr. J. Med. Med. Sci., 39: 41-46.
PubMed  |  
27:   Ren, S.X., A.S.L. Cheng, K.F. To, J.H.M. Tong and M.S. Li et al., 2012. Host immune defense peptide LL-37 activates caspase-independent apoptosis and suppresses colon cancer. Cancer Res., 72: 6512-6523.
CrossRef  |  PubMed  |  
28:   Shen, J., W.K. Wu, S.X. Ren, L. Zhang and R.L. Chan et al., 2013. miRNAs in gastrointestinal and liver cancers: Their perspectives and clinical applications. Curr. Pharm. Des., 19: 1301-1310.
PubMed  |  
29:   Shin, V.Y., W.K. Wu, K.M. Chu, H.P. Wong and E.K. Lam et al., 2005. Nicotine induces cyclooxygenase-2 and vascular endothelial growth factor receptor-2 in association with tumor-associated invasion and angiogenesis in gastric cancer. Mol. Cancer Res., 3: 607-615.
PubMed  |  Direct Link  |  
30:   Shin, V.Y., W.K. Wu, P.S. Wong, E.K. Lam, E.K. Tai, M.W. Koo and C.H. Cho, 2007. Functional role of β-adrenergic receptors in the mitogenic action of nicotine on gastric cancer cells. Toxicol. Sci., 96: 21-29 .
PubMed  |  Direct Link  |  
31:   Shin, V.Y., W.K. Wu, Y.N. Ye, W.H. So and Koo MW et al., 2004. Nicotine promotes gastric tumor growth and neovascularization by activating extracellular signal-regulated kinase and cyclooxygenase-2. Carcinogenesis, 25: 2487-2495.
PubMed  |  Direct Link  |  
32:   Tai, E.K.K., W.K. Wu, H.P.S. Wong, E.K.Y. Lam, L. Yu and C.H. Cho, 2007. A new role for cathelicidin in ulcerative colitis in mice. Exp. Biol. Med., 232: 799-808.
PubMed  |  
33:   Tai, E.K.K., W.K.K. Wu, X.J. Wang, H.P.S. Wong and L. Yu et al., 2013. Intrarectal administration of mCRAMP-encoding plasmid reverses exacerbated colitis in Cnlp(-/-) mice. Gene. Ther., 20: 187-193.
CrossRef  |  PubMed  |  
34:   Tang, J., Y. Sun, W.K. Wu, T. Zhong and Y. Liu et al., 2010. Propofol lowers serum PF4 level and partially corrects hypercoagulopathy in endotoxemic rats. Biochim. Biophys. Act - Proteins Proteomics, 1804: 1895-1901.
PubMed  |  
35:   Wang, L., J.H. Yeung, T. Hu, W.Y. Lee and L. Lu et al., 2013. Dihydrotanshinone induces p53 independent but ROS dependent apoptosis in colon cancer cells. Life Sci., 93: 344-351.
PubMed  |  Direct Link  |  
36:   Wong, C.C.M., L. Zhang, Z.J. Li, W.K. Wu and S.X. Ren et al., 2012. Protective effects of cathelicidin-encoding Lactococcus lactis in murine ulcerative colitis. J. Gastroenterol. Hepatol., 27: 1205-1212.
CrossRef  |  PubMed  |  
37:   Wong, H.P., J.W. Ho, M.W. Koo, L. Yu and W.K. Wu et al., 2011. Effects of adrenaline in human colon adenocarcinoma HT-29 cells. Life Sci., 88: 1108-1112.
CrossRef  |  PubMed  |  
38:   Wong, H.P., L. Yu, E.K.Y. Lam, E.K.K. Tai, W.K. Wu and C.H. Cho, 2007. Nicotine promotes cell proliferation via alpha7-nicotinic acetylcholine receptor and catecholamine-synthesizing enzymes-mediated pathway in human colon adenocarcinoma HT-29 cells. Toxicol. Appl. Pharmacol., 221: 261-267.
PubMed  |  
39:   Wong, H.P.S., L. Yu, E.K. Lam, E.K.Y. Tai, W.K. Wu and C.H. Cho, 2007. Nicotine promotes colon tumor growth and angiogenesis through beta-adrenergic activation. Toxicol. Sci., 97: 279-287.
PubMed  |  
40:   Wong, X.J., J. Yu, S.H. Wong, A.S.L. Cheng and F.K.L. Chan et al., 2013. A novel crosstalk between two major protein degradation systems: Regulation of proteasomal activity by autophagy. Autophagy, 9: 1500-1508.
PubMed  |  
41:   Wu W.K. and J.J.Y. Sung, 2012. MicroRNA dysregulations in gastrointestinal Cancers: Pathophysiological and clinical perspectives. Intest. Res., 10: 324-331.
42:   Wu, W.K. and C.H. Cho, 2004. The pharmacological actions of nicotine on the gastrointestinal tract. J. Pharmacol. Sci., 94: 348-358.
PubMed  |  
43:   Wu, W.K., C.C. Wong, Z.J. Li, L. Zhang, S.X. Ren and C.H. Cho, 2010. Cathelicidins in inflammation and tissue repair: Potential therapeutic applications for gastrointestinal disorders. Act. Pharmacol. Sin., 31: 1118-1122.
PubMed  |  
44:   Wu, W.K., C.H. Cho, C.W. Lee, D. Fan, K. Wu, J. Yu and J.J. Sung, 2010. Dysregulation of cellular signaling in gastric cancer. Cancer Lett., 295: 144-153.
PubMed  |  
45:   Wu, W.K., C.H. Cho, C.W. Lee, D. Fan, K. Wu, J. Yu and J.J. Sung, 2010. Dysregulation of cellular signaling in gastric cancer. Cancer Lett., 295: 144-153.
PubMed  |  
46:   Wu, W.K., C.H. Cho, C.W. Lee, K. Wu, D. Fan, J. Yu and J.J. Sung, 2010. Proteasome inhibition: A new therapeutic strategy to cancer treatment. Cancer Lett., 293: 15-22.
PubMed  |  
47:   Wu, W.K., C.H. Cho, C.W. Lee, Y.C. Wu and L. Yu et al., 2010. Macroautophagy and ERK phosphorylation counteract the antiproliferative effect of proteasome inhibitor in gastric cancer cells. Autophagy, 6: 228-238.
PubMed  |  
48:   Wu, W.K., G. Wang, S.B. Coffelt, A.M. Betancourt and C.W. Lee et al., 2010. Emerging roles of the host defense peptide LL-37 in human cancer and its potential therapeutic applications. Int. J. Cancer, 127: 1741-1747.
PubMed  |  
49:   Wu, W.K., G.R. Li, H.P.S. Wong, M.K.C. Hui and E.K.K. Tai et al., 2006. Involvement of Kv1.1 and Nav1.5 in proliferation of gastric epithelial cells. J. Cell. Physiol., 270: 437-444.
PubMed  |  
50:   Wu, W.K., G.R. Li, T.M. Wong, J.Y. Wang, L. Yu and C.H. Cho, 2008. Involvement of voltage-gated K+ and Na+ channels in gastric epithelial cell migration. Mol. Cell. Biochem., 308: 219-226.
PubMed  |  
51:   Wu, W.K., H.P. Wong, S.W. Luo, K. Chan and F.Y. Huang et al., 2005. 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone from cigarette smoke stimulates colon cancer growth via β-adrenoceptors. Cancer Res., 65: 5272-5277.
PubMed  |  
52:   Wu, W.K., J.J. Sung, C.W. Lee, J. Yu and C.H. Cho, 2010. Cyclooxygenase-2 in tumorigenesis of gastrointestinal cancers: An update on the molecular mechanism. Cancer Lett., 295: 7-16.
PubMed  |  
53:   Wu, W.K., J.J. Sung, K.F. To, L. Yu and H.T. Li et al., 2010. The host defense peptide LL-37 activates the tumor-suppressing bone morphogenetic protein signaling via inhibition of proteasome in gastric cancer cells. J. Cell Physiol., 223: 178-186.
PubMed  |  
54:   Wu, W.K., J.J.Y. Sung, L. Yu and C.H. Cho, 2008. Proteasome inhibitor MG-132 lowers gastric adenocarcinoma TMK1 cell proliferation via bone morphogenetic protein signaling. Biochem. Biophys. Res. Commun., 371: 209-214.
PubMed  |  
55:   Wu, W.K., J.J.Y. Sung, L. Yu, Z.J. Li, K.M. Chu and C.H. Cho, 2008. Constitutive hypophosphorylation of extracellular signal- regulated kinases-1/2 and down-regulation of c-Jun in human gastric adenocarcinoma. Biochem. Biophys. Res. Commun., 373: 330-334.
PubMed  |  
56:   Wu, W.K., J.J.Y. Sung, Y.C. Wu, H.T. Li, L. Yu, Z.J. Li and C.H. Cho, 2009. Inhibition of cyclooxygenase-1 lowers proliferation and induces macroautophagy in colon cancer cells. Biochem. Biophys. Res. Commun., 382: 79-84.
PubMed  |  Direct Link  |  
57:   Wu, W.K., J.J.Y. Sung, Y.C. Wu, Z.J. Li, L. Yu and C.H. Cho, 2008. Bone morphogenetic protein signalling is required for the anti-mitogenic effect of the proteasome inhibitor MG-132 on colon cancer cells. Br. J. Pharmacol., 154: 632-638.
PubMed  |  
58:   Wu, W.K., P.T. Law, C.W. Lee, C.H. Cho and D. Fan et al., 2011. MicroRNA in colorectal cancer: From benchtop to bedside. Carcinogenesis, 32: 247-253.
PubMed  |  
59:   Wu, W.K., P.T. Law, H.P.S. Wong, E.K.Y. Lam, E.K.K. Tai, V.Y. Shin and C.H. Cho, 2007. Shift of homeostasis from parenchymal regeneration to fibroblast proliferation induced by lipopolysaccharide-activated macrophages in gastric mucosal healing in vitro. Wound Repair Regen., 15: 221-226.
PubMed  |  
60:   Wu, W.K., T.T. Tse, J.J. Sung, Z.J. Li, L. Yu and C.H. Cho, 2009. Expression of ErbB receptors and their cognate ligands in gastric and colon cancer cell lines. Anticancer Res., 29: 229-234.
PubMed  |  
61:   Wu, W.K., V. Volta, C.H. Cho, Y.C. Wu and H.T. Li et al., 2009. Repression of protein translation and mTOR signaling by proteasome inhibitor in colon cancer cells. Biochem. Biophys. Res. Commun., 386: 598-601.
CrossRef  |  Direct Link  |  
62:   Wu, W.K., V.Y. Shin, Y.N. Ye, H.P. Wong and F.Y. Huang et al., 2006. Heparin increases human gastric carcinoma cell growth. Anticancer Res., 26: 439-443.
PubMed  |  
63:   Wu, W.K., Y.C. Wu, L. Yu, Z.J. Li, J.J.Y. Sung and C.H. Cho, 2008. Induction of autophagy by proteasome inhibitor is associated with proliferative arrest in colon cancer cells. Biochem. Biophys. Res. Commun., 374: 258-263.
PubMed  |  
64:   Wu, W.K.K., C.W. Lee, C.H. Cho, D. Fan, K. Wu, J. Yu and J.J.Y. Sung, 2010. MicroRNA dysregulation in gastric cancer: A new player enters the game. Oncogene, 29: 5761-5771.
CrossRef  |  
65:   Wu, W.K.K., S.B. Coffelt, C.H. Cho, X.J. Wang and C.W. Lee et al., 2012. The autophagic paradox in cancer therapy. Oncogene, 31: 939-953.
PubMed  |  
66:   Wu, W.K.K., X.J. Wang, A.S.L. Cheng and M.X.M. Luo et al., 2013. Dysregulation and crosstalk of cellular signaling pathways in colon carcinogenesis. Crit. Rev. Oncol. Hematol., 86: 251-277.
CrossRef  |  PubMed  |  
67:   Wu, Y.C., W.K. Wu, Y. Li, L. Yu and Z.J. Li et al., 2009. Inhibition of macroautophagy by bafilomycin A1 lowers proliferation and induces apoptosis in colon cancer cells. Biochem. Biophys. Res. Commun., 382: 541-546.
PubMed  |  
68:   Wu, Y.C., X.J. Wang, L. Yu, F.K.L. Chan and A.S.L. Cheng et al., 2012. Hydrogen sulfide lowers proliferation and induces protective autophagy in colon epithelial cells. PLoS ONE, Vol. 7. .
PubMed  |  
69:   Yang, Y.H., W.K. Wu, E.K. Tai, H.P. Wong and E.K. Lam et al., 2006. The cationic host defense peptide rCRAMP promotes gastric ulcer healing in rats. J. Pharmacol. Exp. Ther., 318: 547-554.
CrossRef  |  PubMed  |  
70:   Ye, C.G., W.K. Wu, J.H.K. Yeung, H.T. Li and Z.J. Li et al., 2011. Indomethacin and SC236 enhance the cytotoxicity of doxorubicin in human hepatocellular carcinoma cells via inhibiting P-glycoprotein and MRP1 expression. Cancer Lett., 304: 90-96.
PubMed  |  
71:   Ye, Y.N., E.S. Liu, V.Y. Shin, W.K. Wu and C.H. Cho, 2004. Contributory role of 5-lipoxygenase and its association with angiogenesis in the promotion of inflammation-associated colonic tumorigenesis by cigarette smoking. Toxicology, 203: 179-188.
PubMed  |  Direct Link  |  
72:   Ye, Y.N., E.S. Liu, V.Y. Shin, W.K. Wu and C.H. Cho, 2004. The modulating role of nuclear factor-kappaB in the action of alpha7-nicotinic acetylcholine receptor and cross-talk between 5-lipoxygenase and cyclooxygenase-2 in colon cancer growth induced by 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone. J. Pharmacol. Exp. Ther., 311: 123-130.
PubMed  |  Direct Link  |  
73:   Ye, Y.N., E.S. Liu, V.Y. Shin, W.K. Wu, J.C. Luo and C.H. Cho, 2004. Nicotine promoted colon cancer growth via epidermal growth factor receptor, c-Src and 5-lipoxygenase-mediated signal pathway. J. Pharmacol. Exp. Ther., 308: 66-72.
PubMed  |  Direct Link  |  
74:   Ye, Y.N., W.K. Wu, V.Y. Shin and C.H. Cho, 2005. A mechanistic study of colon cancer growth promoted by cigarette smoke extract. Eur. J. Pharmacol., 519: 52-57.
CrossRef  |  Direct Link  |  
75:   Ye, Y.N., W.K. Wu, V.Y. Shin, I.C. Bruce, B.C. Wong and C.H. Cho, 2005. Dual inhibition of 5-LOX and COX-2 suppresses colon cancer formation promoted by cigarette smoke. Carcinogenesis, 26: 827-834 .
PubMed  |  Direct Link  |  
76:   Yu, J., X. Ma, K.F. Cheung, X. Li and L. Tian et al., 2010. Epigenetic inactivation of T-box transcription factor 5, a novel tumor suppressor gene, is associated with colon cancer. Oncogene, 29: 6464-6474.
PubMed  |  
77:   Zhang, L., J. Yu, C.C.M. Wong, T.K.W. Ling and Z.J. Li et al., 2013. Cathelicidin protects against Helicobacter pylori colonization and the associated gastritis in mice. Gene. Ther., 20: 751-760.
PubMed  |  
78:   Zhang, L., J.W. Ren, C.C.M. Wong, W.K. Wu and S.X. Ren et al., 2012. Effects of cigarette smoke and its active components on ulcer formation and healing in the gastrointestinal mucosa. Curr. Med. Chem., 19: 63-69.
PubMed  |