Hi, I am Zhe-Sheng Jason Chen, My LiveDNA is 86.5980
 
   
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Dr. Zhe-Sheng Jason Chen
 
Highest Degree: Ph.D. in Cancer Pharmacology from Kagoshima University, Japan
 
Institute: St. John's University, USA
 
Area of Interest: Biomedical Sciences
  •   Chemotherapeutic Agents
  •   Multidrug Resistance
  •   Resistance Mechanisms
  •   Anticancer Drugs
 
URL: http://livedna.org/86.5980
 
My SELECTED Publications
1:   Abraham, I., K. El Sayed, Z.S. Chen and H. Guo, 2012. Current status on marine products with reversal effect on cancer multidrug resistance. Mar. Drugs, 10: 2312-2321.
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2:   Abraham, I., S. Jain, C.P. Wu, M.A. Khanfar and Y. Kuang et al., 2010. Marine sponge-derived sipholane triterpenoids reverse P-glycoprotein (ABCB1)-mediated multidrug resistance in cancer cells. Biochem. Pharmacol., 80: 1497-1506.
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3:   Akiyama, S., T. Furukawa, T. Sumizawa, A. Tani and Z.S. Chen, 1998. Reversing drug resistance: Cyclosporins. Med. Pharmacol. J., 34: 107-111.
4:   Akiyama, S., Z.S. Chen and T. Furukawa, 1999. Expression of P-glycoprotein and MRP in human tumors. Best New Med., 54: 382-389.
5:   Akiyama, S., Z.S. Chen, M. Kitazono, T. Sumizawa, T. Furukawa and T. Aikou, 1999. Mechanisms for resistance to anticancer agents and the reversal of the resistance. Hum. Cell, 12: 95-102.
PubMed  |  
6:   Akiyama, S., Z.S. Chen, T. Sumizawa and T. Furukawa, 1999. Resistance to cisplatin. Anticancer Drugs Designs, 14: 143-151.
7:   An, X., A.K. Tiwari, Y. Sun, P.R. Ding, C.R. Ashby Jr. and Z. S. Chen, 2010. BCR-ABL tyrosine kinase inhibitors in the treatment of Philadelphia chromosome positive chronic myeloid leukemia: A review. Leukemia Res., 34: 1255-1268.
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8:   Anreddy, N., A. Patel, K. Sodani, R.J. Kathawala, E.P. Chen, J.N. Wurpel and Z.S. Chen, 2014. PD173074, a selective FGFR inhibitor, reverses MRP7 (ABCC10)-mediated MDR. Acta Pharm. Sin. B, 4: 202-207.
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9:   Anreddy, N., P. Gupta, R.J. Kathawala, A. Patel, J.N. Wurpel and Z.S. Chen, 2014. Tyrosine kinase inhibitors as reversal agents for ABC transporter mediated drug resistance. Molecules, 19: 13848-13877.
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10:   Aoki, S., A. Setiawan, Y. Yoshioka, K. Higuchi and R. Fudetani et al., 1999. Reversal of multidrug resistance in human carcinoma cell line by agosterols, marine spongean sterols. Tetrahedron, 55: 13965-13972.
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11:   Aoki, S., Y. Yoshida, Y. Miyamoto, K. Higuchi and A. Setiawan et al., 1998. Agosterol A, a novel polyhydroxylated sterol acetate reversing multidrug resistance from a marine sponge of Spongia Sp. Tetrahedron Lett., 39: 6303-6306.
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12:   Aoki, S., Z.S. Chen, K. Higasiyama, A. Setiawan, S. Akiyama and M. Kobayashi, 2001. Reversing effect of agosterol A, a spongean sterol acetate, on multidrug resistance in human carcinoma cells. Jap. J. Cancer Res., 92: 886-895.
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13:   Belinsky, M.G., P.A. Dawson, I. Shchaveleva, L.J. Bain and R. Wang et al., 2005. Analysis of the in vivo functions of mrp3. Mol. Pharmacol., 68: 160-168.
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14:   Belinsky, M.G., Z.S. Chen, I. Shchaveleva, H. Zeng and G.D. Kruh, 2002. Characterization of the drug resistance and transport properties of multidrug resistance protein 6 (MRP6, ABCC6). Cancer Res., 62: 6172-6177.
PubMed  |  Direct Link  |  
15:   Chen, G., R. Chen, C. Zou, D. Yang and Z.S. Chen, 2014. Fragmented polymer nanotubes from sonication-induced scission with a thermo-responsive gating system for anti-cancer drug delivery. J. Mater. Chem. B, 2: 1327-1334.
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16:   Chen, J., D.P. Brown, Y.J. Wang and Z.S. Chen, 2013. New phenstatin-fatty acid conjugates: Synthesis and evaluation. Bioorganic Med. Chem. Lett., 23: 5119-5122.
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17:   Chen, J.J., A. Patel, K. Sodani, Z.J. Xiao and A.K. Tiwari et al., 2013. BBA, a Synthetic derivative of 23-hydroxybutulinic acid, reverses multidrug resistance by inhibiting the efflux activity of MRP7 (ABCC10). PLoS ONE, (In Press). 10.1371/journal.pone.0074573.
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18:   Chen, J.J., Y.L. Sun, A.K. Tiwari, Z.J. Xiao and K. Sodani et al., 2012. PDE5 inhibitors, sildenafil and vardenafil, reverse multidrug resistance by inhibiting the efflux function of multidrug resistance protein 7 (ATP-binding Cassette C10) transporter. Cancer Sci., 103: 1531-1537.
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19:   Chen, Z.S. and A.K. Tiwari, 2011. Multidrug resistance proteins (MRPs/ABCCs) in cancer chemotherapy and genetic diseases. FEBS J., 278: 3226-3245.
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20:   Chen, Z.S. and J.L. Zhou, 1990. Study on the interactions between glutathione, glutathione-associate enzymes and white phosphorus poisoning. J. Hygiene Toxicol., 4: 18-20.
21:   Chen, Z.S., E. Hopper-Borge, M.G. Belinsky, I. Shchaveleva, E. Kotova and G.D. Kruh, 2003. Characterization of the transport properties of human multidrug resistance protein 7 (MRP7, ABCC10). Mol. Pharmacol., 63: 351-358.
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22:   Chen, Z.S., J.Y. Lin, H.J. Xu, L.X. Lu and W. Cai, 1995. Evaluation of the effects of QZJ-air filtrator. Chin. J. Disinfect., 12: 3-4.
23:   Chen, Z.S., K. Lee and G.D. Kruh, 2001. Transport of cyclic nucleotides and estradiol 17-β-d-glucuronide by multidrug resistance protein 4: Resistance to 6-mercaptopurine and 6-thioguanine. J. Biol. Chem., 276: 33747-33754.
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24:   Chen, Z.S., K. Lee, S. Walther, R.B. Raftogianis, M. Kuwano, H. Zeng and G.D. Kruh, 2002. Analysis of methotrexate and folate transport by multidrug resistance protein 4 (ABCC4): MRP4 is a component of the methotrexate efflux system. Cancer Res., 62: 3144-3150.
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25:   Chen, Z.S., M. Mutoh, T. Sumizawa, T. Furukawa and M. Haraguchi et al., 1998. An active efflux system for heavy metals in cisplatin-resistant human KB carcinoma cells. Exp. Cell Res., 240: 312-320.
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26:   Chen, Z.S., M. Mutoh, T. Sumizawa, T. Furukawa, M. Haraguchi, A. Tani and S. Akiyama, 1997. Reversal of heavy metal resistance in multidrug-resistant human KB carcinoma cells. Biochem. Biophys. Res. Commun., 236: 586-590.
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27:   Chen, Z.S., Q.M. Chen, R.T. Yuan, X.Y. Zheng and R.H. Zhao, 1990. Investigation of fulminant epidemic acromelalgia in the high school students of Lian-Ping Prefecture. Health Anti-epidemic J Guang Dong Province, 61: 21-24.
28:   Chen, Z.S., R.W. Robey, M.G. Belinsky, I. Shchaveleva and X.Q. Ren et al., 2003. Transport of methotrexate, methotrexate polyglutamates and 17B-Estrodiol 17-(B-D-glucuronide) by ABCG2 (BCRP/MXR): Effects of acquired mutations at R482 on methotrexate transport. Cancer Res., 63: 4048-4054.
PubMed  |  Direct Link  |  
29:   Chen, Z.S., S. Aoki, M. Komatsu, K. Ueda and T. Sumizawa et al., 2001. Reversal of drug resistance mediated by multidrug resistance protein (MRP) 1 by dual effects of agosterol A on MRP1 function. Int. J. Cancer, 93: 107-113.
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30:   Chen, Z.S., T. Furukawa, T. Sumizawa, K. Ono, K. Ueda, K. Seto and S. Akiyama, 1999. ATP-Dependent efflux of CPT-11 and SN-38 by the multidrug resistance protein (MRP) and its inhibition by PAK-104P. Mol. Pharmacol., 55: 921-928.
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31:   Chen, Z.S., T. Kawabe, M. Ono, S. Aoki and T. Sumizawa et al., 1999. Effect of multidrug resistance-reversing agents on transporting activity of human canalicular multispecific organic anion transporter. Mol. Pharmacol., 56: 1219-1228.
PubMed  |  Direct Link  |  
32:   Chen, Z.S., T. Sumizawa, T. Furukawa, K. Ono, A. Tani, M. Komatsu and S. Akiyama, 1999. An enhanced active efflux of CPT-11 and SN-38 in cisplatin-resistant human KB carcinoma cells. Cancer Lett., 138: 13-22.
PubMed  |  Direct Link  |  
33:   Chen, Z.S., W.Cai, H.J. Xu, L.X. Lu and J.Y. Lin, 1990. Toxicological studies of Mie Yi Lin (cyclopentadiene). Health Anti-epidemic J. Guang Dong Province, 59: 45-47.
34:   Chen, Z.S., Y. Guo, M.G. Belinsky, E. Kotova and G.D. Kruh, 2005. Transport of bile acids, sulfated steroids, Estradiol 17-β-D-Glucuronide and leukotriene C4 by human multidrug resistance protein 8 (ABCC11). Mol. Pharmacol., 67: 545-557.
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35:   Cheng, C., Z.G. Liu, H. Zhang, J.D. Xie and X.G. Chen et al., 2012. Enhancing chemosensitivity in ABCB1- and ABCG2-overexpressing cells and cancer stem-like cells by an aurora kinase inhibitor CCT129202. Mol. Pharm., 9: 1971-1982.
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36:   Chuman, Y., Z.S. Chen, K. Seto, T. Sumizawa and T. Furukawa et al., 1998. Reversal of MRP-mediated vincristine resistance in KB cells by buthionine sulfoximine in combination with PAK-104P. Cancer Lett., 129: 69-76.
PubMed  |  Direct Link  |  
37:   Chuman, Y., Z.S. Chen, T. Sumizawa, T. Furukawa and M. Haraguchi et al., 1996. Characterization of the ATP-dependent LTC4 transporter in cisplatin-resistant human KB cells. Biochem. Biophys. Res. Commun., 226: 158-165.
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38:   Dai, C.L., A.K. Tiwari, C.P. Wu, X.D. Su and S.R. Wang, Liu et al., 2008. Lapatinib (Tykerb, GW572016) reverses multidrug resistance in cancer cells by inhibiting the activity of ATP-binding cassette subfamily B member 1 and G member 2. Cancer Res., 68: 7905-7914.
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39:   Dai, C.L., Y.J. Liang, L.M. Chen, X. Zhang and W.J. Deng et al., 2009. Sensitization of ABCB1 overexpressing cells to chemotherapeutic agents by FG020326 via binding to ABCB1 and inhibiting its function. Biochem. Pharmacol., 78: 355-364.
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40:   Dai, C.L., Y.J. Liang, Y.S. Wang, A.K. Tiwari and Y.Y. Yan et al., 2009. Sensitization of ABCG2-overexpressing cells to conventional chemotherapeutic agent by sunitinib was associated with inhibiting the function of ABCG2. Cancer Lett., 279: 74-83.
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41:   Deng, W., B. Hu, C.L. Dai, Y.J. Wang and H.F. Chen et al., 2013. Anticancer activity of oldenlandia diffusa and viola Philippica car. J. Cancer Res., 2: 87-94.
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42:   Deng, W., C.L. Dai, J.J. Chen, R. Kathawala, Y.L. Sun, H.F. Chen and Z.S. Chen, 2013. Tandutinib(MLN518) reverses multidrug resistance by inhibiting the efflux activity of the MRP7 (ABCC10). Oncol. Rep., 29: 2479-2485.
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43:   Ding, P.R., A.K. Tiwari, S. Ohnuma, J.W. Lee and X. An et al., 2011. The phosphodiesterase-5 inhibitor vardenafil is a potent inhibitor of ABCB1/P-glycoprotein transporter. PloS One, Vol. 6. 10.1371/journal.pone.0019329.
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44:   Fujii, R., M. Mutoh, T. Sumizawa, Z.S. Chen, A. Yoshimura and S. Akiyama, 1994. Adenosine triphosphate-dependent transport of leukotriene C4 by membrane vesicles prepared from cisplatin-resistant human epidermoid carcinoma tumor cells. J. Natl. Cancer Inst., 86: 1781-1784.
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45:   Furukawa, T., Z.S. Chen and S. Akiyama, 1997. ATP-dependent glutathione conjugate export pump. Nippon Rinsho, 55: 1083-1090.
PubMed  |  
46:   Furukawa, T., Z.S. Chen, T. Sumizawa and S. Akiyama, 1998. The mechanism of anticancer-drug resistance: Cisplatin. Med. Pharmacol. J., 34: 66-72.
47:   Guo, H.Q., D.S. Wang, G.H. Rizwani, M. Ahmed and M. Ahmed et al., 2013. Antineoplastic activity of Holoptelea integrifolia (Roxb.) Planch bark extracts (in vitro). Pak. J. Pharm. Sci., 26: 1151-1156.
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48:   Guo, H.Q., G.N. Zhang, Y.J. Wang, Y.K. Zhang and K. Sodani et al., 2014. β-elemene, a compound derived from Rhizoma zedoariae, reverses multidrug resistance mediated by the ABCB1 transporter. Oncol. Rep., 31: 858-866.
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49:   Guo, Y., E. Kotova, Z.S. Chen, K. Lee, E. Hopper-Borge, M.G. Belinsky and G.D. Kruh, 2003. MRP8, ATP-binding cassette C11 (ABCC11), is a cyclic nucleotide efflux pump and a resistance factor for fluoropyrimidines 2',3'-dideoxycytidine and 9'-(2'-phosphonylmethoxyethyl)adenine. J. Biol. Chem., 278: 29509-29514.
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50:   Guo, Y., K. Kock, C.A. Ritter, Z.S. Chen and M. Grube et al., 2009. Expression of ABCC-type nucleotide exporters in blasts of adult acute myeloid leukemia: Relation to long-term survival. Clin. Cancer Res., 15: 1762-1769.
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51:   Haraguchi, M., H. Tsujimoto, M. Fukushima, I. Higuchi and H. Kuribayashi et al., 2002. Targeted deletion of both thymidine phosphorylase and uridine phosphorylase and consequent disorders in mice. Mol. Cell Biol., 22: 5212-5221.
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52:   Hasinoff, B.B., X. Wu, A.A. Yadav, D. Patel and H. Zhang et al., 2015. Cellular mechanisms of the cytotoxicity of the anticancer drug elesclomol and its complex with Cu (II). Biochem. Pharmacol., 93: 266-276.
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53:   He, D., X.Q. Zhao, X.G. Chen, Y. Fang and S. Singh et al., 2013. BIRB796, the inhibitor of p38 mitogen-activated protein kinase, enhances the efficacy of chemotherapeutic agents in ABCB1 overexpression cells. PloS One, Vol. 8. 10.1371/journal.pone.0054181.
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54:   Hopper-Borge, E., X. Xu, T. Shen, Z. Shi, Z.S. Chen and G.D. Kruh, 2009. Human multidrug resistance Protein 7 (ABCC10) is a resistance factor for nucleoside analogues and epothilone B. Cancer Res., 69: 178-184.
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55:   Hopper-Borge, E., Z.S. Chen, I. Shchaveleva, M.G. Belinsky and G.D. Kruh, 2004. Analysis of the drug resistance profile of multidrug resistance protein 7 (ABCC10): Resistance to docetaxel. Cancer Res., 64: 4927-4930.
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56:   Hopper-Borge, E.A., T. Churchill, C. Paulose, E. Nicolas and J.D. Jacobs et al., 2011. Contribution of Abcc10 (Mrp7) to in vivo paclitaxel resistance as assessed in Abcc10−/− mice. Cancer Res., 71: 3649-3657.
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57:   Huang, X.C., P. Kumar, N. Anreddy, X. Xiao, D.H. Yang and Z.S. Chen, 2013. P-gp Inhibitory Activity from Marine Sponges, Tunicates and Algae. In: Anticancer Drugs from Marine Origin, Kim, S.K. (Ed.). Springer, New York, USA.
58:   Huang, X.C., X. Xiao, Y.K. Zhang, T.T. Talele, A.A. Salim, Z.S. Chen and R.J. Capon, 2014. Lamellarin O, a pyrrole alkaloid from an Australian marine sponge, Ianthella sp., reverses BCRP mediated drug resistance in cancer cells. Mar. Drugs, 12: 3818-3837.
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59:   Huang, X.C., Y.L. Sun, A. Salim, Z.S. Chen and R.J. Capon, 2013. Parguerenes: Marine red alga bromoditerpenes as inhibitors of P-glycoprotein (ABCB1) in multidrug resistant human cancer cells. Biochem. Pharmacol., 85: 1257-1268.
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60:   Jain, S., I. Abraham, P. Carvalho, Y.H. Kuang and L.A. Shaala et al., 2009. Sipholane triterpenoids: Chemistry, reversal of ABCB1/P-glycoprotein-mediated multidrug resistance and pharmacophore modeling. J. Nat. Prod., 72: 1291-1298.
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61:   Jain, S., S. Laphookhieo, Z. Shi, L.W. Fu and S. Akiyama et al., 2007. Reversal of P-glycoprotein-mediated multidrug resistance by sipholane triterpenoids. J. Nat. Prod., 70: 928-931.
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62:   Jason Chen, Z.S., 2011. Editorial [hot topic: ABC transporters in pharmacology/physiology and human diseases (Guest Editor: Zhe-Sheng (Jason) Chen)]. Curr. Pharm. Biotechnol., 12: 569-569.
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63:   Kathawala, R.J., J.J. Chen, Y.K. Zhang, Y.J. Wang and A. Patel et al., 2014. Masitinib antagonizes ATP-binding cassette subfamily G member 2-mediated multidrug resistance. Int. J. Oncol., 44: 1634-1642.
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64:   Kathawala, R.J., K. Sodani, K. Chen, A. Patel and A.H. Abuznait et al., 2014. Masitinib antagonizes ATP-binding cassette subfamily C member 10-mediated paclitaxel resistance: A preclinical study. Mol. Cancer Ther., 13: 714-723.
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65:   Kathawala, R.J., L. Wei, N. Anreddy, K. Chen and A. Patel et al., 2014. The small molecule tyrosine kinase inhibitor NVP-BHG712 antagonizes ABCC10-mediated paclitaxel resistance: A preclinical and pharmacokinetic study. Oncotarget, Vol. 6. .
PubMed  |  Direct Link  |  
66:   Kathawala, R.J., P. Gupta, C.R. Ashby and Z.S. Chen, 2015. The modulation of ABC transporter-mediated multidrug resistance in cancer: A review of the past decade. Drug Resistance Updates, 18: 1-17.
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67:   Kathawala, R.J., Y.J. Wang, C.R. Ashby Jr and Z.S. Chen, 2014. Recent advances regarding the role of ABC subfamily C member 10 (ABCC10) in the efflux of antitumor drugs. Chin. J. Cancer, 33: 223-230.
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68:   Kathawala, R.J., Y.J. Wang, S. Shukla, Y.K. Zhang and S. Alqahtani et al., 2015. ATP-binding cassette subfamily B member 1 (ABCB1) and subfamily C member 10 (ABCC10) are not primary resistance factors for cabazitaxel. Chin. J. Cancer, Vol. 34. 10.1186/s40880-015-0003-0.
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69:   Kawabe, T., Z.S. Chen, M. Wada, T. Uchiumi, M. Ono, S. Akiyama and M. Kuwano, 1999. Enhanced transport of anticancer agents and leukotriene C4 by the human canalicular multispecific organic anion transporter (cMOAT/MRP2). FEBS Lett., 456: 327-331.
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70:   Kitazono, M., T. Sumizawa, Y. Takebayashi, Z.S. Chen and T. Furukawa et al., 1999. Multidrug resistance and the lung resistance-related protein in human colon carcinoma SW-620 cells. J. Nat. Cancer Inst., 91: 1647-1653.
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71:   Kobayashi, J., H. Shigemori, H. Hosoyama, Z.S. Chen, S. Akiyama, M. Naito and T. Tsuruo, 2000. Multidrug resistance reversal activity of taxoids from Taxus cuspidate in KB-C2 and 2780AD cells. Cancer Res., 91: 638-642.
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72:   Komatsu, M., T. Sumizawa, M. Mutoh, Z.S. Chen and K. Terada et al., 2000. Copper-transporting P-type adenosine triphosphatase (ATP7B) is associated with cisplatin resistance. Cancer Res., 60: 1312-1316.
PubMed  |  Direct Link  |  
73:   Kruh, G.D., H. Zeng, P.A. Rea, G. Liu, Z.S. Chen, K. Lee and M.G. Belinsky, 2001. MRP subfamily transporters and resistance to anticancer agents. J. Bioenerg. Biomembr., 33: 493-501.
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74:   Kruh, G.D., Y. Guo, E. Hopper-Borge, M.G. Belinsky and Z.S. Chen, 2006. ABCC10, ABCC11 and ABCC12. Eur. J. Physiol., 453: 675-684.
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75:   Kuang, Y.H., J. Patel, K. Sodani, C.P. Wu and L.Q. Liao et al., 2012. OSI-930 analogues as novel reversal agents for ABCG2-mediated multidrug resistance. Biochem. Pharmacol., 84: 766-774.
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76:   Kuang, Y.H., T. Shen, X. Chen, K. Sodani and E. Hopper-Borge et al., 2010. Lapatinib and erlotinib are potent reversal agents for MRP7 (ABCC10)-mediated multidrug resistance. Biochem. Pharmacol., 79: 154-161.
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77:   Kuang, Y.H., X. Chen, J. Su, L.S. Wu and J. Li et al., 2008. Proteome analysis of multidrug resistance of human oral squamous carcinoma cells using CD147 silencing. J. Proteome Res., 7: 4784-4791.
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78:   Kuang, Y.H., X. Chen, J. Su, L.S. Wu and L.Q. Liao et al., 2009. RNA interference targeting the CD147 induces apoptosis of multi-drug resistant cancer cells related to XIAP depletion. Cancer Lett., 276: 189-195.
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79:   Kumar, P., D.M. Zhang, K. Degenhardt and Z.S. Chen, 2012. Autophagy and transporter-based multi-drug resistance. Cells, 1: 558-575.
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80:   Li, T., Y. Yang, C. Cheng, A.K. Tiwari and K. Sodani et al., 2012. Design, synthesis and biological evaluation of N-arylphenyl-2,2-dichloroacetamide analogues as anti-cancer agents. Bioorg. Med. Chem., 22: 7268-7271.
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81:   Li, T.W., Y.C. Yang, C.M. Cheng, A.K. Tiwari and K. Sodani et al., 2012. N-arylphenyl-2,2-dichloroacetamide analogues as anti-cancer agents: Design, synthesis and biological evaluation. Bioorganic Med. Chem. Lett., 22: 7268-7274.
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82:   Li, X., H. Xu, Z.S. Chen and G. Chen, 2011. Biosynthesis of nanoparticles by microorganisms and their applications. J. Nanomaterials, (In Press). 10.1155/2011/270974.
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83:   Lin, J.Y., Z.S. Chen and W. Cai, 1993. Studies on the evaluational standards of toxicological test for cosmetics. Health Anti-epidemic J. Guang Dong Province, 70: 12-15.
84:   Liu, D.L., Y.J. Li, D.H. Yang, C.R. Wang and J. Xu et al., 2015. Ganoderma lucidum derived ganoderenic acid B reverses ABCB1-mediated multidrug resistance in HepG2/ADM cells. Int. J. Oncol., 46: 2029-2038.
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