Dr. De-an  Guo

Dr. De-an Guo

Professor
Chinese Academy of Sciences, China


Highest Degree
Ph.D. in Pharmacognosy from Beijing Medical University, China

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Area of Interest:

Biomedical Sciences
100%
TCM Quality Control
62%
Metabolism
90%
Natural Products Chemistry
75%
Pharmacokinetics
55%

Education

1990

Ph.D.

Beijing Medical University, China

Pharmacognosy

Selected Publications

  1. Hou, J.J., W.Y. Wu and D.A. Guo, 2014. A single, multi-faceted, enhanced strategy to quantify the chromatographically diverse constituents in the roots of Euphorbia kansui. J. Pharmaceut. Biomed. Anal., 88: 321-330.
    CrossRef  |  

  2. Zhang, J.X., S.H. Guan, R.H. Feng, Y. Wang and Z.Y. Wu et al., 2013. Neolignanamides, lignanamides and other phenolic compounds from the root bark of Lycium chinense. J. Nat. Prod., 76: 51-58.
    CrossRef  |  

  3. Zhang, J.X., S.H. Guan, M. Yang, R.H. Feng and Y. Wang et al., 2013. Simultaneous determination of 24 constituents in Cortex Lycii using high-performance liquid Chromatography-triple quadrupole mass spectrometry. J. Pharm. Biomed. Anal., 77: 63-70.

  4. Zeng, F., W. Wang, S.H. Guan, C.R. Cheng and M. Yang et al., 2013. Simultaneous quantification of 18 bioactive constituents in Tripterygium wilfordii using liquid chromatography-electrospray ionization-mass spectrometry. Planta Med., 79: 797-805.
    CrossRef  |  PubMed  |  Direct Link  |  

  5. Yang, W.Z., T. Bo, S. Ji, X. Qiao, D.A. Guo and M. Ye, 2013. Rapid chemical profiling of saponins in the flower buds of Panax notoginseng by integrating MCI gel column chromatography and liquid chromatography/mass spectrometry analysis. Food Chem., 139: 762-769.
    CrossRef  |  

  6. Yang, W.Z., G. Ye, A.H. Meng, G. Sabir, X. Qiao, D.A. Guo and M. Ye, 2013. Rapid characterisation of flavonoids from Sophora alopecuroides L. by HPLC/DAD/ESI-MS n. Nat. Prod. Res., 27: 323-330.
    CrossRef  |  

  7. Xu, T., M. Yang, Y. Li, X. Chen and Q. Wang et al., 2013. An integrated exact mass spectrometric strategy for comprehensive and rapid characterization of phenolic compounds in licorice. Rapid Commun. Mass Spectrom., 27: 2297-2309.
    CrossRef  |  

  8. Wang, Y., S.H. Guan, Y.H. Meng, Y.B. Zhang and C.R. Cheng et al., 2013. Phenanthrenes, 9, 10-dihydrophenanthrenes, bibenzyls with their derivatives and malate or tartrate benzyl ester glucosides from tubers of Cremastra appendiculata. Phytochemistry, 94: 268-276.
    CrossRef  |  

  9. Wang, Q., S. Ji, S.W. Yu, H.X. Wang and X.H. Lin et al., 2013. Three new phenolic compounds from the roots of Glycyrrhiza yunnanensis. Fitoterapia, 85: 35-40.
    CrossRef  |  

  10. Ma, B., Z.Y. Xiao, Y.J. Chen, M. Lei and Y.H. Meng et al., 2013. Synthesis and Structure-activity relationships study of cytotoxic bufalin 3-Nitrogen-containing-ester derivatives. Steroids, 78: 508-512.
    CrossRef  |  

  11. Liu, X., W.Y. Wu, B.H. Jiang, M. Yang and D.A. Guo, 2013. Pharmacological tools for the development of traditional Chinese medicine. Trends Pharm. Sci., 34: 620-628.
    CrossRef  |  

  12. Liu, C.F., X. Qiao, K.D. Liu, W.J. Miao and Y.J. Li et al., 2013. In vivo metabolites and plasma exposure of TongMaiKeli analyzed by UHPLC/DAD/qTOF-MS and LC/MS/MS. J. Ethnopharmacol., 145: 509-516.

  13. Liang, J., W.Y. Wu, G.X. Sun, D.D. Wang and J.J. Hou et al., 2013. A dynamic multiple reaction monitoring method for the multiple components quantification of complex traditional Chinese medicine preparations: Niuhuang Shangqing pill as an example. J. Chromatogr. A, 1294: 58-69.
    CrossRef  |  PubMed  |  Direct Link  |  

  14. Li, D., S. Liu, F. Teng, W. Yang and L. Zhang et al., 2013. Temporal change of leukocytes and chemokines in aortic dissection patient: Relationship to regional lesion on aorta. Int. J. Cardiol., 168: 3065-3066.
    CrossRef  |  

  15. Jiang, B., D. Li, Y. Deng, F. Teng and J. Chen et al., 2013. Salvianolic acid a, a novel matrix metalloproteinase-9 inhibitor, prevents cardiac remodeling in spontaneously hypertensive rats. Plos One, Vol. 8. 10.1371/journal.pone.0059621.
    CrossRef  |  

  16. Gu, J., R. Feng, Z. Wu, S. Guan and J. Guo et al., 2013. A rapid and convenient method for preparative separation of three indissolvable polyphenols from Euphorbia pekinensis by the flexible application of solvent extraction combined with Counter-current chromatography. J. Sep. Sci., 36: 2366-2372.
    CrossRef  |  

  17. Feng, L.X., D.M. Zhang, C.Y. Fan, C. Ma and W.M. Yang et al., 2013. ER stress-mediated apoptosis induced by celastrol in cancer cells and important role of glycogen synthase kinase-3β in the signal network. Cell Death Dis., Vol. 4. 10.1038/cddis.2013.222.
    CrossRef  |  PubMed  |  Direct Link  |  

  18. Cheng, C.R., M. Yang, S.H. Guan, X.H. Wu and X.Y. Pang et al., 2013. Pharmacokinetics of ganoderic acid D and its main metabolite by liquid chromatography-tandem mass spectrometry. J. Chromatogr. B, 930: 1-6.
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  19. Yue, Q.X., F.B. Xie, X.Y. Song, W.Y. Wu and B.H. Jiang et al., 2012. Proteomic studies on protective effects of salvianolic acids, notoginsengnosides and combination of salvianolic acids and notoginsengnosides against cardiac ischemic-reperfusion injury. J. Ethnopharmacol., 141: 659-667.

  20. Yuan, J., D. Yang, Y. Liang, W. Gao and Z. Ren et al., 2012. Alkaloids from areca (betel) nuts and their effects on human sperm motility in vitro. J. Food Sci., 77: T70-T78.
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  21. Ye, M., W.Z. Yang, K.D. Liu, X. Qiao and B.J. Li et al., 2012. Characterization of flavonoids in Millettia nitida var. hirsutissima by HPLC/DAD/ESI-MSn. J. Pharm. Anal., 2: 35-42.
    CrossRef  |  Direct Link  |  

  22. Yang, W.Z., M. Ye, X. Qiao, Q. Wang, T. Bo and D.A. Guo, 2012. Collision-induced dissociation of 40 flavonoid aglycones and differentiation of the common flavonoid subtypes using electrospray ionization ion-trap tandem mass spectrometry and quadrupole time-of-flight mass spectrometry. Eur. J. Mass Spectrom., 18: 493-503.
    PubMed  |  

  23. Yang, W.Z., M. Ye, X. Qiao, C.F. Liu and W.J. Miao et al., 2012. A strategy for efficient discovery of new natural compounds by integrating orthogonal column chromatography and liquid chromatography/mass spectrometry analysis: Its application in Panax ginseng, Panax quinquefolium and Panax notoginseng to characterize 437 potential new ginsenosides. Anal. Chim. Acta, 739: 56-66.
    CrossRef  |  

  24. Yang, W.Z., M. Ye, F.X. Huang, W.N. He and D.A. Guo, 2012. Biocatalysis of cycloastragenol by filamentous fungi to produce unexpected triterpenes. Adv. Synth. Catal., 354: 527-539.
    CrossRef  |  Direct Link  |  

  25. Yang, M., Z.Q. Lu, K. Yu, Q.R. Wang and X. Chen et al., 2012. Studies on the fragmentation pathways of ingenol esters isolated from Euphorbia esula using IT-MSn and Q-TOF-MS/MS methods in electrospray ionization mode. Int. J. Mass Spectrom., 323: 55-62.
    CrossRef  |  

  26. Yang, M., C. Cheng, J. Yang and D.A. Guo, 2012. Metabolite profiling and characterization for medicinal herbal remedies. Curr. Drug Metab., 13: 535-557.
    Direct Link  |  

  27. Xu, P., S. Guan, R. Feng, R. Tang and D. Guo, 2012. Separation of Four homoisoflavonoids from caesalpinia sappan by high-speed counter-current chromatography. Phytochem. Anal., 23: 228-231.
    CrossRef  |  Direct Link  |  

  28. Wu, X., J. Ruan, V.C. Yang, Z. Wu and J. Lou et al., 2012. Three new acetylated benzyl-β-resorcylate glycosides from Cassia obtusifolia. Fitoterapia, 83: 166-169.
    CrossRef  |  PubMed  |  Direct Link  |  

  29. Wu, H., R.H. Feng, S.G. Guan, W.B. Yu and W. Man et al., 2012. Rapid preparative isolation of a new phenylpropanoid glycoside and four minor compounds from Sparganium stoloniferum using high-speed counter-current chromatography as a fractionation tool. J. Sep. Sci., 35: 1160-1166.
    CrossRef  |  PubMed  |  Direct Link  |  

  30. Wang, W.B., L.X. Feng, Q.X. Yue, W.Y. Wu and S.H. Guan et al., 2012. Paraptosis accompanied by autophagy and apoptosis was induced by celastrol, a natural compound with influence on proteasome, ER stress and Hsp90. J. Cell Physiol., 227: 2196-2206.
    CrossRef  |  Direct Link  |  

  31. Uzuner, H., R. Bauer, T.P. Fan, D.A. Guo and A. Dias et al., 2012. Traditional Chinese medicine research in the post-genomic era: Good practice, priorities, challenges and opportunities. J. Ethnopharmacol., 140: 458-468.
    CrossRef  |  PubMed  |  Direct Link  |  

  32. Tao, S.J., Y. Wang, X. Zhang, S.H. Guan and D.A. Guo, 2012. Biotransformation of gambogenic acid by Chaetomium globosum CICC 2445. Nat. Prod. Commun., 7: 197-198.
    PubMed  |  

  33. Tang, R.N., X.B. Qu, S.H. Guan, P.P. Xu, Y.Y. Shi and D.A. Guo, 2012. Chemical constituents of Spatholobuss uberectus. Chinese J. Nat. Med., 10: 32-35.
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  34. Song, W., M. Lei, K. Zhao, L. Hu and Y. Meng et al., 2012. Ceric ammonium nitrate-promoted oxidative coupling reaction for the synthesis and evaluation of a series of anti-tumor amide anhydrovinblastine analogs. Bioorg. Med. Chem. Lett., 22: 387-390.
    CrossRef  |  PubMed  |  Direct Link  |  

  35. Song, W., L. Hu, Y. Meng, L. Ma, D. Guo, X. Liu and L. Hu, 2012. The effect of vindoline C-16 substituents on the biomimetic coupling reaction: Synthesis and cytotoxicity evaluation of the corresponding vinorelbine analogues. Bioorg. Med. Chem. Lett., 22: 3485-3487.
    CrossRef  |  PubMed  |  Direct Link  |  

  36. Shi, Y.Y., S.H. Guan, R.N. Tang, S.J. Tao and D.A. Guo, 2012. Simultaneous determination of atractylenolide II and atractylenolide III by liquid chromatography-tandem mass spectrometry in rat plasma and its application in a pharmacokinetic study after oral administration of Atractylodes Macrocephala Rhizoma extract. Biomed. Chromatogr., 26: 1386-1392.
    CrossRef  |  

  37. Shi, Y.Y., S.H. Guan, R.N. Tang, S.J. Tao and D.A. Guo et al., 2012. Simultaneous determination of four sesquiterpenoids in Atractylodes Macrocephala Rhizoma by GC-FID: Optimisation of an ultrasound-assisted extraction by central composite design. Phytochem. Anal., 23: 408-414.
    CrossRef  |  

  38. Qiao, X., M. Ye, C.F. Liu, W.Z. Yang, W.J. Miao, J. Dong and D.A. Guo, 2012. A tandem mass spectrometric study of bile acids: Interpretation of fragmentation pathways and differentiation of steroid isomers. Steroids, 77: 204-211.
    CrossRef  |  PubMed  |  Direct Link  |  

  39. Qiao, X., M. Ye, C. Xiang, T. Bo and W.Z. Yang et al., 2012. Metabolic regulatory effects of licorice: A bile acid metabonomic study by liquid chromatography coupled with tandem mass spectrometry. Steroids, 77: 745-755.
    Direct Link  |  

  40. Qiao, X., M. Ye, C. Xiang, Q. Wang, C.F. Liu, W. J. Miao and D.A. Guo, 2012. Analytical strategy to reveal the in vivo process of multi-component herbal medicine: A pharmacokinetic study of licorice using liquid chromatography coupled with triple quadrupole mass spectrometry. J. Chromatogr. A, 1258: 84-93.
    CrossRef  |  

  41. Qiao, X., G. Ye, C.F. Liu, Z.X. Zhang and Q. Tu et al., 2012. Chemical analysis of Eriocaulon buergerianum and adulterating species by high-performance liquid chromatography with diode array detection and electrospray ionization tandem mass spectrometry. J. Pharm. Biomed. Anal., 57: 133-142.
    CrossRef  |  PubMed  |  Direct Link  |  

  42. Pan, S.N., Y.H. Wang, L.X. Feng, C.Y. Fan, D.A. Guo, X. Liu and J.L. Fan, 2012. [Study on proteomics of Hela cell apoptosis in bufalin-induced human cervical carcinoma]. Zhongguo Zhong Yao Za Zhi., 13: 1998-2004.
    PubMed  |  

  43. Miao, W.J., Q. Wang, T. Bo, M. Ye and X. Qiao et al., 2012. Rapid characterization of chemical constituents and rats metabolites of the traditional Chinese patent medicine Gegen-Qinlian-Wan by UHPLC/DAD/qTOF-MS. J. Pharm. Biomed. Anal., 72: 99-108.
    CrossRef  |  

  44. Li, H.F., X.Y. Guan, W.Z. Yang, K.D. Liu and M. Ye et al., 2012. Antioxidant flavonoids from Epimedium wushanense. Fitoterapia, 83: 44-48.
    CrossRef  |  Direct Link  |  

  45. Jiang, B., K. Sun, M. Li, Y. Wang and L. Zhuang et al., 2012. Study of luan-pao-prescription on ovarian dysfunction in rats. J. Ethnopharmacol., 141: 653-658.
    CrossRef  |  Direct Link  |  

  46. Huang, F.X., X.H. Lin, W.N. He, W. Song, M. Ye, W.Z. Yang and D.A. Guo, 2012. Two new oxidation products obtained from the biotransformation of asiatic acid by the fungus Fusarium avenaceum AS 3.4594. J. Asian Nat. Prod. Res., 14: 1039-1045.
    CrossRef  |  PubMed  |  Direct Link  |  

  47. Huang, F.X., W.Z. Yang, F. Ye, J.Y. Tian and H.B. Hu et al., 2012. Microbial transformation of ursolic acid by Syncephalastrum racemosum (Cohn) Schroter AS 3.264. Phytochemistry, 82: 56-60.
    CrossRef  |  PubMed  |  Direct Link  |  

  48. Fan, C.Y., L.X. Feng, J.L. Fan, D.A. Guo and X. Liu, 2012. Recent progress in protein recombinant expression. Biotechnology, 2: 76-80.

  49. Fan, C.Y., L.X. Feng, D.M. Zhang, S.N. Pan, X. Liu, D.A. Guo and J.L. Fan, 2012. The expression and purification of the human proteome subunit- PSMB1 and its application in in vitro screening of proteome inhibitors. Chin. J. Biotech., 2: 233-242.

  50. Du, X.G., W. Wang, Q.Y. Zhang, J. Cheng, B. Avula, I.A. Khan and D.A. Guo, 2012. Identification of xanthones from Swertia punicea using high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry. Rapid Commun. Mass Spectrom., 26: 2913-2923.
    CrossRef  |  Direct Link  |  

  51. Da, J., W.Y. Wu, J.J. Hou, H.L. Long and S. Yao et al., 2012. Comparison of two officinal Chinese pharmacopoeia species of Ganoderma based on chemical research with multiple technologies and chemometrics analysis. J. Chromatogr. A, 1222: 59-70.
    CrossRef  |  PubMed  |  Direct Link  |  

  52. Cheng, C.R., Y.F. Li, P.P. Xu, R.H. Feng, M. Yang, S.H. Guan and D.A. Guo, 2012. Preparative isolation of triterpenoids from Ganoderma lucidum by counter-current chromatography combined with pH-zone-refining counter-current. Food Chem., 130: 1010-1016.
    CrossRef  |  Direct Link  |  

  53. Cheng, C.R., M. Yang, K. Yu, S.H. Guan, A. Millar, X.Y. Pang and D.A. Guo, 2012. Identification of metabolites of ganoderic acid D by ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry. Drug Metab. Dispos., 40: 2307-2314.
    CrossRef  |  PubMed  |  Direct Link  |  

  54. Chen, W.F., Q.G. Gao, Z.J. Dai, A.W.C. Kung, D.A. Guo and M.S. Wong, 2012. Estrogenic effects of ginsenoside Rg1 in endometrial cells in vitro were not observed in immature CD-1 mice or ovariectomized mice model. Menopause, 19: 1052-1061.
    PubMed  |  

  55. Chen, H., J. Yin, Y.P. Deng, M. Yang and L.L. Xu et al., 2012. The protective effects of ginsenoside Rg1 against hypertension target-organ damage in spontaneously hypertensive rats. BMC Complem. Altern. Med., Vol. 12. 10.1186/1472-6882-12-53.
    CrossRef  |  Direct Link  |  

  56. Chakrabortee, S., Y. Liu, L. Zhang, H.R. Matthews and H.R. Zhang et al., 2012. Macromolecular and small-molecule modulation of intracellular Aβ42 aggregation and associated toxicity. Biochem. J., 442: 507-515.
    CrossRef  |  PubMed  |  Direct Link  |  

  57. Zhang, X., M. Ye, Y.J. Gong, L.M. Feng, S.J. Tao, J. Yin and D.A. Guo, 2011. Biotransformation of pseudolaric acid B by Chaetomium globosum. Process. Biochem., 46: 2064-2067.
    Direct Link  |  

  58. Zhang, X., M. Ye, Y.H. Dong, H.B. Hu, J. Yin and D.A. Guo, 2011. Biotransformation of bufadienolides by cell suspension cultures of Saussurea involucrate. Phytochemistry, 72: 1779-1785.
    Direct Link  |  

  59. Xiang, C., X. Qiao, Q. Wang, R. Li, W. Miao, D. Guo and M. Ye, 2011. From single compounds to herbal extract: A strategy to systematically characterize the metabolites of licorice in rats. Drug Metab. Dispos., 39: 1597-1608.
    CrossRef  |  

  60. Wu, X.H., J.J. Cai, J.L. Ruan J.S. Lou and H.Q. Duan et al., 2011. Acetylated anthraquinone glycosides from Cassia obtusifolia. J. Asian Nat. Prod. Res., 13: 486-491.
    CrossRef  |  

  61. Wang, Y., F. Xu, J. Chen, X. Shen and Y. Deng et al., 2011. Matrix metalloproteinase-9 induces cardiac fibroblast migration, collagen and cytokine secretion: Inhibition by salvianolic acid B from Salvia miltiorrhiza. Phytomedicine, 9: 13-19.
    CrossRef  |  

  62. Qiao, X., W.Z. Yang, D.A. Guo and M. Ye, 2011. Extraction, separation, detection and structural analysis of flavonoids. Curr. Org. Chem., 15: 2541-2566.
    CrossRef  |  

  63. Qiao, X., W.N. He, C. Xiang, J. Han, L.J. Wu, D.A. Guo and M. Ye, 2011. Qualitative and quantitative analyses of flavonoids in Spirodela polyrrhiza by high-performance liquid chromatography coupled with mass spectrometry. Phytochem. Anal., 22: 475-483.
    PubMed  |  

  64. Qiao, X., M. Ye, Y.H. Liang, W.Z. Yang and D.A. Guo, 2011. Retention behaviors of natural products in reversed-phase liquid chromatography using mobile phase comprising methanol, acetonitrile and water. J. Sep. Sci., 34: 169-175.
    PubMed  |  Direct Link  |  

  65. Qiao, X., M. Ye, D.L. Pan, W.J. Miao, C. Xiang, J. Han and D.A. Guo, 2011. Differentiation of various traditional Chinese medicines derived from animal bile and gallstone: Simultaneous determination of bile acids by liquid chromatography coupled with triple quadrupole mass spectrometry. J. Chromatogr. A, 1218: 107-117.
    PubMed  |  

  66. Qiao, X., J. Han, M. Xu, Z.C. Zhang, M. Ye, G. Ye and D.A. Guo, 2011. Metabolic profiling of Guan Xin II prescription based on metabolic fingerprinting and chemical analysis. J. Pharm. Biomed. Anal., 54: 789-798.
    Direct Link  |  

  67. Pang, X., J. Cheng, K.W. Krausz, D.A. Guo, F.J. Gonzalez, 2011. Pregnane X receptor-mediated induction of Cyp3a by black cohosh. Xenobiotica, 41: 112-123.
    CrossRef  |  

  68. Liu, X., Y. Wang, C. Ma, L. Zhang and W. Wu et al., 2011. Proteomic assessment of tanshinone IIA sodium sulfonate on doxorubicin induced nephropathy. Am. J. Chin. Med., 39: 395-409.
    Direct Link  |  

  69. Liu, X. and D.A. Guo, 2011. Application of proteomics in the mechanistic study of traditional Chinese medicine. Biochem. Soc. Trans., 39: 1348-1352.
    PubMed  |  

  70. Liu, P., J.H. Sun, M. Xu, H. Guo and H.Z. Guo et al., 2011. Characterization of diterpenoids in the bark of Pseudolarix kaempferi by HPLC-ESI/MSn. Yao Xue Xue Bao, 46: 213-220.
    Direct Link  |  

  71. Liu, K.D., X. Qiao, D.A. Guo and M. Ye, 2011. HPLC fingerprint analysis of Drynaria Rhizome. Chinese Herbal Med., 42: 510-514.

  72. Liang, Y.H., M. Ye, X. Qiao, H.J. Yang, X.L. Wang and D.A. Guo, 2011. Flavan-3-ols from the Rhizomes of Drynaria fortunei. Phytochemistry, 72: 1876-1882.
    Direct Link  |  

  73. Liang, Y.H., M. Ye, J. Han, B.R. Wang and D.A. Guo, 2011. Lignans and flavonoids from Drynaria Rhizome. Chinese Herbal Med., 42: 25-30.

  74. Li, R., M. Ye and D.A. Guo, 2011. Metabolic and pharmacokinetic studies of curcumin, demethoxycurcumin and bisdemethoxycurcumin in mice tumor after intragastric administration of nanoparticle formulations by liquid chromatography coupled with tandem mass spectrometry. J. Chromatogr. B, 879: 2751-2758.
    PubMed  |  

  75. Li, R., C. Xiang, M. Ye, H.F. Li, X. Zhang and D.A. Guo, 2011. Qualitative and quantitative analysis of curcuminoids in herbal medicines derived from Curcuma species. Food Chem., 126: 1890-1895.
    CrossRef  |  Direct Link  |  

  76. Li, H.F., X.Y. Guan, M. Ye, C. Xiang, C.H. Lin, C. Sun and D.A. Guo, 2011. Qualitative and quantitative analyses of Epimedium wushanense by high-performance liquid chromatography coupled with diode array detection and electrospray ionization tandem mass spectrometry. J. Sep. Sci., 34: 1437-1446.
    CrossRef  |  

  77. Hou, J.J., W.Y. Wu, J. Da, S. Yao and H.L. Long et al., 2011. Ruggedness and robustness of conversion factors in method of simultaneous determination of multi-components with single reference standard. J. Chromatogr. A, 1218: 5618-5627.
    PubMed  |  

  78. He, X., W. Yang, M. Ye, Q. Wang and D. Guo, 2011. Differentiation of cuscuta chinensis and cuscuta australis by HPLC-DAD-MS analysis and HPLC-UV quantitation. Planta Med., 77: 1950-1957.
    CrossRef  |  

  79. Guan, X.Y., H.F. Li, W.Z. Yang, C.H. Lin and C. Sun et al., 2011. HPLC-DAD-MS(n) analysis and HPLC quantitation of chemical constituents in Xian-ling-gu-bao capsules. J. Pharm. Biomed. Anal., 55: 923-933.
    CrossRef  |  

  80. Grienke, U., J. Mihaly-Bison, D. Schuster, D.A. Guo and S.H. Guan et al., 2011. Computer-aided discovery of farnesoid X receptor-inducing triterpenes from Ganoderma lucidum. Bio. Med. Chem., 19: 6779-6791.

  81. Feng, L.X., C.J. Jing, K.L. Tang, L. Tao and Z.W. Cao et al., 2011. Clarifying the signal network of salvianolic acid B using proteomic assay and bioinformatic analysis. Proteomics, 11: 1473-1485.
    PubMed  |  

  82. Fan, L., R. Pu, X. Liu, J. Han, B.R. Wang and D.A. Guo, 2011. Anti-PAF aggregation activity of Carthamus tinctorius. Chin. J. Chinese Mater. Med., 36: 67-69.

  83. Cheng, C.R., M. Yang, Z.Y. Wu, Y. Wang and F. Zeng et al., 2011. Fragmentation pathways of oxygenated tetracyclic triterpenoids and their application in the qualitative analysis of Ganoderma lucidum by multistage tandem mass spectrometry. Rapid Commun. Mass Spectrom., 25: 1323-1335.
    CrossRef  |  

  84. Zhao, H., Y. Luo, C. Lu, N. Lin and C. Xiao et al., 2010. Enteric mucosal immune response might trigger the immunomodulation activity of Ganoderma lucidum polysaccharide in mice. Planta Med., 76: 223-227.
    PubMed  |  

  85. Zhao, H., M. Fan, L. Fan, J. Sun and D.A Guo, 2010. Liquid chromatography-tandem mass spectrometry analysis of metabolites in rats after administration of prenylflavonoids from Epimediums. J. Chromatogr. B, 8787: 1113-1124.
    CrossRef  |  PubMed  |  

  86. Zeng, F., W. Wang, Y. Wu, M. Dey and M. Ye et al., 2010. Two prenylated and C-methylated flavonoids from Tripterygium wilfordii. Planta Med., 76: 1596-1599.
    Direct Link  |  

  87. Yue, Q.X., X. Liu and D.A. Guo, 2010. Microtubule-binding natural products for cancer therapy. Plant. Med., 76: 1037-1043.
    CrossRef  |  

  88. Yin, Y., M. Yang, Y. Wang, X. Liu and W. Wu et al., 2010. Tanshinone IIA increases mRNA expression of efflux transporters in cultured human intestinal cell. Am. J. Chin Med., 38: 995-1004.
    CrossRef  |  Direct Link  |  

  89. Wu, X.H., J.L. Ruan, C.R. Chen, Z.Y. Wu and S.H. Guan et al., 2010. Benzyl-beta-resorcylates from Cassia obtusifolia. Fitoterapia, 81: 617-620.
    PubMed  |  

  90. Uzuner, H., T.P. Fan, A. Dias, D.A. Guo, H.S. El-Nezami and Q. Xu, 2010. Establishing an EU-China consortium on traditional Chinese medicine research. Chin. Med., 5: 42-42.
    CrossRef  |  

  91. Qiao, X., X. Zhang, M. Ye, Y.F. Su and J. Dong et al., 2010. Rapid characterization of triterpene saponins from Conyza blinii by liquid chromatography coupled with mass spectrometry. Rapid Commun. Mass Spectrom, 24: 3340-3350.
    CrossRef  |  

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  296. Ye, M., L. Ning, J. Zhan, H. Guo and D.A. Guo, 2003. Biotransformation of cinobufagin by cell suspension cultures of Catharanthus roseus and Platycodon grandiflorum. J. Mol. Catal. B: Enzymatic, 22: 89-95.
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  297. Ye, M., J.G. Dai and D.A. Guo, 2003. Biotransformation of cantharidin by cell suspension cultures of Platycodon grandiflorus. Chin. Traditional Herbal Drug, 34: 869-871.
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  298. Ye, G., Y.Z. Li, Y.Y. Li, H.Z. Guo and D.A. Guo, 2003. SPE-HPLC method for the determination and pharmacokinetic studies on paeoniflorin in rat serum after oral administration of traditional Chinese medicinal preparation Guan-Xin-Er-Hao decoction. J. Pharmaceut. Biomed. Anal., 33: 521-527.
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  299. Ye, G., P. Han, H.Z. Guo and D.A. Guo, 2003. Quantitative determination of paeoniflorin in Guanxin II recipe by SPE-HPLC method. Chin. Traditional Herbal Drug, 34: 919-920.

  300. Ye, G., H. Guo and D.A. Guo, 2003. Studies on the chemical constituents of Guanxi II recipe. Chin. Traditional Herbal Drug, 34: 89-90.

  301. Ye, G., C.S. Wang, Y.Y. Li, H. Ren and D.A. Guo, 2003. Simultaneous determination and pharmacokinetic studies on (3,4-dihydroxyphenyl)-lactic acid and protocatechuic aldehyde in rat serum after oral administration of Radix salviae miltiorrhizae extract. J. Chromatogr. Sci., 41: 327-330.
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  302. Wang, Z.Y., R.Q. Qian, S.H. Guan, X.Z. Feng, D.A. Guo, J.J. Ying and J.F. Lu, 2003. Studies on the free radical mechanism of Guanxin II recipe anti-ischemicmyocardial damage effect. Chin. J. Integr. Trad. West Med., 23: 363-366.

  303. Wang, Z.H., D.A. Guo and C.H. Hu, 2003. Simultaneous determination of brucine and strychnine in human blood by reversed phase high performance liquid chromatography. Chin. J. Chromatogr., 4: 382-384.

  304. Su, Y.F., K. Koike, T. Nikaido, J. Liu, J. Zheng and D.A. Guo, 2003. Conyzasaponins I-Q, nine new triterpenoid saponins from Conyza blinii. J. Nat. Prod., 66: 1593-1599.
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  305. Ning, L., X. Jiang, M. Ye, H. Guo, K. Bi and D.A. Guo, 2003. Structural determination and complete NMR spectral assignments of a new diterpenoid obtained from triptonide by biotransformation. Magn. Resonance Chem., 41: 633-635.
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  306. Ning, L., J. Zhan, G. Qu, L. Zhong, H. Guo, K. Bi and D.A. Guo, 2003. Biotransformation of triptolide by Cunninghamella blakesleana. Tetrahedron, 59: 4209-4213.
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  307. Ning, L., H. Guo, X. Jiang, K. Bi and D.A. Guo, 2003. Biotransformation of triptonide by cell suspension cultures of Platycodon grandiflorum. Pure Applied Chem., 75: 389-392.
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  308. Ning, L., G. Qu, M. Ye, H. Guo, K. Bi and D.A. Guo, 2003. Cytotoxic biotransformed products from triptonide by Aspergillus niger. Planta Medica, 69: 804-808.
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  309. Han, J., J.G. Dai, Y.J. Cui, J.X. Zhan, H.Z. Guo and D.A. Guo, 2003. Biotransformation of artemisinin by Catharanthus roseus and Ginkgo biloba cell suspension cultures. Chin. Trad. Herbal Drug, 34: 166-168.

  310. Guo, D.A., 2003. Several key issues in the process of TCM modernization. Chin. Traditional Herbal Drug, 34: 9-11.

  311. Dong, A., M. Ye, H. Guo, J. Zheng and D.A. Guo, 2003. Microbial transformation of ginsenoside Rb1 by Rhizopus stolonifer and Curvularia lunata. Biotechnol. Lett., 25: 339-344.
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  312. Dai, J.G., H.Z. Guo, M. Ye, W.H. Zhu and D.Y. Zhang et al., 2003. Biotransformation of 4(20),11-taxadienes by cell suspension cultures of Platycodon grandiflorum. J. Asian Nat. Prod. Res., 5: 5-10.
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  313. Dai, J., H. Guo, M. Ye, W. Zhu and D. Zhang et al., 2003. Highly regio- and stereo-selective hydroxylation of 4(20), 11-taxadienes by Ginkgo cell suspension cultures. Bioorg. Chem., 31: 345-356.

  314. Chow, L.M.C., C. Chui, J.C.O. Tang, F. Lau and M.Y.C. Yau et al., 2003. Anti-angiogenic potential of Gleditsia sinensis fruit extract. Int. J. Mol. Med., 12: 269-273.
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  315. Zhang, L., Y. Zhang, Y.M. Zhou, S. An, D.A. Guo, Y.X. Zhou and L.W. Zeng, 2002. Analysis of gene expressionof Saccharomyces cerevisiae cells after treatment by antifungal agent. Progr. Biochem. Biophys., 29: 538-542.

  316. Zhan, J.X., Y.X. Zhang, H.Z. Guo, J. Han, L.L. Ning and D.A. Guo, 2002. Microbial metabolism of artemisinin by Mucor polymorphosporus and Aspergillus niger. J. Nat. Prod., 65: 1693-1695.
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  317. Zhan, J., H. Guo, J. Dai, Y. Zhang and D.A. Guo, 2002. Microbial transformations of artemisinin by Cunninghamella echinulata and Aspergillus niger. Tetrahedron Lett., 43: 4519-4521.
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  318. Ye, M., J. Han, H. Guo and D.A. Guo, 2002. Structural determination and complete NMR spectral assignments of a new bufadienolide glycoside. Magnet. Resonance Chem., 40: 786-788.
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  319. Ye, M., J. Dai, H. Guo and D.A. Guo, 2002. Glucosylation of cinobufagin by cultured suspension cells of Catharanthus roseus. Tetrahedron Lett., 43: 8535-8538.
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  320. Xiang, L., G. Fan, J. Li, H. Kang, Y. Yan, J. Zheng and D.A. Guo, 2002. The application of an artificial neural network in the identification of medicinal rhubarbs by near-infrared spectroscopy. Phytochem. Anal., 13: 272-276.
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  321. Wang, L.D., D.Y. Qiu, J.Y. Chen, Y.F. Han, J.H. Zheng and D.A. Guo, 2002. Callus cultures of Annona squamosa for the production of Annonaceous acetongenins. J. Asian Nat. Prod. Res., 4: 171-174.

  322. Su, Y., K. Koike, D.A. Guo, J. Jia, J. Liu, J. Zheng and T. Nikaido, 2002. Three new labdane diterpenoid glycoside from Conyza blinii. Heterocycles, 56: 265-271.

  323. Liu, Y., M. Ye, H.Z. Guo, Y.Y. Zhao and D.A. Guo, 2002. New thiophenes from Echinops grijisii. J. Asian Nat. Prod. Res., 4: 175-178.
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  324. Liu, Y., G. Ye, Y.J. Cui, A.Y. Zhang, Y.Y. Zhao and D.A. Guo, 2002. Studies on the chemical constituents of the aerial parts of Echinops grijisii. Chin. Trad. Herb Drug, 33: 18-20.

  325. Li, L.X., Y.F. Su, X.F. Liu and D.A. Guo, 2002. Biotransformation of artemisinin by hairy root cultures of Rheum palmatum L. J. Chin. Pharm. Sci., 11: 122-124.
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  326. Gong, Y.J., L.D. Wang, J.H. Zheng and D.A. Guo, 2002. Antifungal activity of 164 ethanolic extracts from traditional Chinese medicines. Chin. Trad. Herb Drug, 33: 42-47.

  327. Dong, A.L., J.H. Zheng, D.A. Guo, Y.P. Duan, C. Qin and G.Q. Fan, 2002. A simple and fast method for the isolation of trace compound notoginsenoside R2 in Panax notoginseng. Chin. J. Chin. Mat. Med., 27: 793-794.

  328. Dai, J.G., Z. Gong and D.M. Zhu et al., 2002. Biotransformation of gastrodin by cell supension cultures of Gatharanthus roseus. Acta Botanica Sinica, 44: 377-378.

  329. Dai, J., Y. Cui, W. Zhu, H. Guo and M. Ye et al., 2002. Biotransformation of 2α, 5α, 10β, 14β-tetraacetoxy-4(20),11-taxadiene by cell suspension cultures of Catharanthus roseus. Planta Medica, 68: 1113-1117.
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  330. Dai, J., M. Ye, H. Guo, W. Zhu and D. Zhang et al., 2002. Regio- and stereo-selective biotransformation of 2α, 5α, 10β, 14β-tetra-acetoxy-4(20), 11-taxadiene by Ginkgo cell suspension cultures. Tetrahedron, 58: 5659-5668.
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  331. Chow, L.M.C., J.C.O. Tang, I.T.N. Teo, C.H. Chui and F.Y. Lau et al., 2002. Antiproliferative activity of the extract of Gleditsia sinensis Fruit on human solid tumour cell lines. Exp. Chemother., 48: 303-308.
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  332. Chan, R.Y., W.F. Chen, A. Dong, D.A. Guo and M.S. Wong, 2002. Estrogen-like activity of ginsenoside Rg1 derived from Panax notoginseng. J. Clin. Endocrinol. Metab., 87: 3691-3695.
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  333. Bo, T., L. Zhong, M. Li, Y. Luo, K. Li, H. Liu and D.A. Guo, 2002. Separation of isoquinoline alkaloids and saponins by microemulsion electrokinetic chromatography with anionic and cationic surfactants. Chromatographia, 56: 709-716.
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  334. Zhan, J.X., H.Z. Guo, J.G. Dai, Y.X. Zhang and D.A. Guo, 2001. Biotransformation of gastrodin by Mucor spinosus. J. Chin. Pharm. Sci., 10: 187-189.
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  335. Wang, L.D., Y.Q. Hu, P.F. Tu, Z.W. Wu, J.H. Zheng and D.A. Guo, 2001. Antifungal screening of thirteen crude extracts and compounds from Chinese crude drugs. Chin. Trad. Herb Drug, 32: 241-241.

  336. Su, Y.F., J.S. Liu, D.A. Guo, Q. Li, H.Z. Guo and J.H. Zheng, 2001. Studies on the flavones of Conyza blinii. Chin. Trad. Herb Drug, 32: 496-496.

  337. Su, Y.F., J.S. Liu, D.A. Guo, M.E. Sun, H.Z. Guo and J.H. Zheng, 2001. Saponins from the plants of family composite. World Phytomed., 16: 12-12.

  338. Su, Y.F., D.A. Guo, Y.J. Cui, J.S. Liu and J.H. Zheng, 2001. A new phenolic glycoside and a new trans-clerodane diterpene from Conyza blinii. J. Asian Nat. Prod. Res., 3: 229-233.
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  339. Su, Y.F., D.A. Guo, M.E. Sun, J.H. Zheng, J.S. Liu and S.L. Yang, 2001. Studies on the terpenoids of Conyza blinii. Chin. Trad. Herb Drug, 32: 496-496.

  340. Su, Y., K. Koike, D.A. Guo, J. Liu, J. Zheng and T. Nikaido, 2001. New Apinose-containing triterpenoid saponins from Conyza blinii. Tetrahedron, 57: 6721-6726.

  341. Su, Y., J. Zheng, D.A. Guo and J. Ma, 2001. Phytochemical and bioactive studies on Conyza blinii. J. Chin. Pharm. Sci., 10: 106-108.

  342. Su, Y., D.A. Guo, H. Guo, J. Liu, J. Zheng, K. Koike and T. Nikaido, 2001. Four new triterpenoid saponins from Conyza blinii. J. Nat. Prod., 64: 32-36.

  343. Guo, D.A., 2001. Basics in Traditional Chinese Medicine. China Medical and Pharmaceutical Press, Beijing, China.

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  346. Guo, D.A., 2001. Basics in Chemistry of Traditional Chinese Medicine. China Medical and Pharmaceutical Press, Beijing, China.

  347. Fu, H.Z., K. Koike, Q. Zheng, K. Mitsunaga and Z.H. Jia et al., 2001. Fargosides A-E, triterpenoid saponins from Holboellia fargesii. Chem. Pharm. Bull., 49: 999-1002.

  348. Dong, A., H. Guo, J. Zheng and D.A. Guo, 2001. Biotransformation of ginsenoside Rg1 by microbial organisms. J. Chin. Pharm. Sci., 10: 115-118.

  349. Dai, J.G., D.D. Lu, Y.J. Cui, H.Z. Guo, J.H. Zheng and D.A. Guo, 2001. Biotransformation of gastrodin using cell suspension cultures of Platycodon grandiflorum. Acta Pharm. Sin., 36: 942-943.

  350. Dai, J., H. Guo, D. Lu, W. Zhu, D. Zhang, J. Zheng and D.A. Guo, 2001. Biotransformation of 2α, 5α, 10β, 14β-tetra-acetoxy-4(20), 11-taxadiene by gingko cell suspension cultures. Tetrhedron Lett., 42: 4677-4679.

  351. Zhang, Z.Z., D.A. Guo, C.L. Li, J.H. Zheng, K. Koike, Z.H. Jia and T. Nikaido, 2000. Gaultherins C and D, two new lignans from Gaultheria yunnanensis. Heterocycles, 53: 675-679.
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  352. Wang, L.D., L. Yuang, Q.H. He, J.H. Zheng and D.A. Guo, 2000. The effect of three antifungal compounds on the genetic substances of two fungal cells. Acta Pharm. Sin., 35: 860-862.

  353. Wang, L.D., D.A. Guo, Y.Q. Hu, P.F. Tu, Y.J. Gong and J.H. Zheng, 2000. Effect of four antifungal natural products on ultrastructure of Prototheca wickerhamii. J. Beijing Med. Univ., 32: 219-222.

  354. Su, Y.F., J.S. Liu, D.A. Guo and J.H. Zheng, 2000. Studies on chemical constituents of Conyza plants. World Phytomed., 15: 190-190.

  355. Su, Y. and D.A. Guo, 2000. Recent progress in biosynthesis of Rauwolfia alkaloids. J. Chin. Pharm. Sci., 9: 50-54.
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  356. Liu, S.Q., J.H. Zheng, H. Wang, X. Chen, C. Qiu and D.A. Guo, 2000. The variation of flavones and ginkgolides in the ginkgo leaves in different climate zones. Chin. Trad. Herb Med., 31: 424-426.

  357. Guo, H.Z., X.F. Liu, T. Yu, D.A. Guo and J.H. Zheng, 2000. Quantification of astragaloside Ⅳ in yifukang capsule by high performance liquid chromatography. China J. Chin. Mat. Med., 25: 609-609.

  358. Guo, D.A., L.D. Wang, D.Y. Qiu, J.Y. Chen, Y.F. Han and J.H. Zheng, 2000. Callus cultures of Annona squamosa for the production of Annonaceous acetongenins. J. Korean Med. Crops, 8: 64-72.

  359. Guo, D.A., 2000. TCM quality evaluation and fingerprints of TCM injections. Chin. Drug Standard, 4: 5-8.

  360. Dai, J.G. and D.A. Guo, 2000. Research progress and future perspective on the biotechnology of traditional Chinese medicine. J. TCM Modernization, 2: 27-30.

  361. Chang, Z.Z., Y.H. Liu, K.K. Lu, D.A. Guo, X. Shen, S.S. Wang and K. Wang, 2000. The effect of Eu2+ on the growth of hairy roots of Cassia obtusifolia and the production of active constituents. J. Rare Earth, 18: 146-149.

  362. Chang, Z.Z. and D.A. Guo, 2000. Production of free anthraquinones by using hairy root cultures of Cassia obtusifolia as a bioreactor. J. Beijing Med. Univ., 32: 142-144.

  363. Zou, K., Y.Y. Zhao, G.Z. Tu, D.A. Guo, R.Y. Zhang and J.H. Zheng, 1999. A triterpenoid saponin from Albizia julibrissin. J. Asian Nat. Prod. Res., 1: 313-318.

  364. Zheng, J.H. and D.A. Guo, 1999. Pharmacognosy. 3rd Edn., People's Health Publishing House, Beijing, China.

  365. Zhang, Z.Z., Z.H. Jia, K. Koike, T. Nikaido, D.A. Guo and J.H. Zheng, 1999. Four new triterpenoidal saponins acylated with one monoterpenic acid from Gleditsia sinensis. J. Nat. Prod., 62: 740-745.
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  366. Zhang, Z.Z., K. Koike, Z.H. Jia, T. Nikaido, D.A. Guo and J.H. Zheng, 1999. Triterpenoidal saponins from Gleditsia sinensis. Phytochemistry, 52: 715-722.
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  367. Zhang, Z.Z., K. Koike, Z.H. Jia, T. Nikaido, D.A. Guo and J.H. Zheng, 1999. Triterpenoidal saponins acylated with two monoterpenic acids from Gleditsia sinensis. Chem. Pharm. Bull., 47: 388-393.
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  368. Zhang, Z.Z., K. Koike, Z.H. Jia, T. Nikaido, D.A. Guo and J.H. Zheng, 1999. New saponins from the seeds of Aesculus chinensis. Chem. Pharm. Bull., 47: 1515-1520.
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  369. Zhang, Z.Z., K. Koike, Z.H. Jia, T. Nikaido, D.A. Guo and J.H. Zheng, 1999. Gleditsiosides N-Q, new triterpenoid saponins from Gleditsia sinensis. J. Nat. Prod., 62: 877-881.
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  370. Zhang, Z.Z., D.A. Guo, C.L. Li, J.H. Zheng, K. Koike, Z.H. Jia and T. Nikaido, 1999. Two direpenoids from Gaultheria yunnanensis. J. Nat. Prod., 62: 297-298.

  371. Zhang, Z.Z., D.A. Guo, C.L. Li, J.H. Zheng, K. Koike, Z.H. Jia and T. Nikaido, 1999. Studies on the chemical constituents of Gaultheria yunnanensis (III). China Trad. Herb. Drug, 30: 247-250.

  372. Zhang, Z.Z., D.A. Guo, C.L. Li, J.H. Zheng, K. Koike, Z.H. Jia and T. Nikaido, 1999. Studies on the chemical constituents of Gaultheria yunnanensis (II). China Trad. Herb. Drug, 30: 167-170.

  373. Zhang, Z.Z., D.A. Guo, C.L. Li, J.H. Zheng, K. Koike, Z.H. Jia and T. Nikaido, 1999. Gaultherin A and B, two new lignans from Gaultheria yunnanensis. Phytochemistry, 51: 469-472.

  374. Zhang, Z.Z., D.A. Guo, C.L. Li and J.H. Zheng, 1999. Studies on the antibacterial, anti-inflammatory and analgesic activities of Gaultheria yunnanensishad. Northwest Pharm. J., 14: 60-61.

  375. Zhang, Z., D. Guo, C. Li, J. Zheng, K. Koike, Z. Jia and T. Nikaido, 1999. Two diterpenoids from the roots of Gaultheria yunnanensis. J. Nat. Prod., 62: 297-298.
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  376. Xu, L., D. Guo, J. Liu, J. Zheng, K. Koike, Z. Jia and T. Nikaido, 1999. A new trans-clerodane diterpene lactone from Conyza blinii. Heterocycle, 51: 605-609.

  377. Lu, K.K., Z.Z. Chang, B.W. Chen, D.A. Guo, J.H. Zheng and K. Wang, 1999. The effect of rare earth on the growth and morphology of plant cells. J. Rare Earth, 17: 136-138.

  378. Koike, K., Z.H. Jia, T. Nikaido, Y. Liu, Y.Y. Zhao and D.A. Guo, 1999. A novel benzothiophene glycoside from the roots of Echinops grijisii. Org. Lett., 1: 197-198.

  379. Cui, Y., L. Wang, R.A. Norton, J. Zheng and D.A. Guo, 1999. Biotransformation of 24α-methylcholesterol and 24β-methylcholesterol by yeast mutant GL7. J. Asian Nat. Prod. Res., 2: 39-44.

  380. Chang, Z.Z., X. Shen, D.A. Guo, S.S. Wang and J.H. Zheng, 1999. Studies on isolated root culture of Ri-plasmid transformed Cassia obtusifolia. J. Beijing Med. Univ., 31: 117-119.

  381. Zhang, Z.Z., H. Wang, Y.G. Zheng, D.A. Guo and J.H. Zheng, 1998. Chemical constitutes from Gaultheria yunnanensis and their bioactivities. J. Beij. Med. Univ., 30: 77-80.

  382. Zhang, Z.Z., D.A. Guo, C.L. Li and J.H. Zheng et al., 1998. Chemical constituents from Gaultheria yunnanensis (Franch.) Rehd. (I). China Trad. Herb. Drug, 29: 508-511.

  383. Xu, L.P., J.S. Liu, D. Min, S.W. Wang, D.A. Guo and J.H. Zheng, 1998. Studies on the chemical constituents of Conyza blinii (I). China J. Chin. Mat. Med., 23: 293-295.

  384. Xu, L.P., J.S. Liu, D. Min, D.A. Guo and J.H. Zheng, 1998. Studies on the chemical constituents of Conyza blinii (II). China J. Mat. Med., 23: 552-553.

  385. Wang, H., D. Min, Y.G. Zheng, Y.J. Shi, D.A. Guo and J.H. Zheng, 1998. Analysis of volatile constituents from Ocimum basilicum. J. Beij. Med. Univ., 30: 52-54.

  386. Min, D., L.P. Xu, Z.Z. Zhang, F. Xue, D.A. Guo and J.H. Zheng, 1998. Studies on the chemical constituents of Rheum wittrochii(II). Zhongguo Zhong Yao Za Zhi, 23: 486-488.
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  387. Min, D., F. Xue, L.P. Xu, Z.Z. Zhang, D.A. Guo and J.H. Zheng, 1998. Studies on the chemical constituents of Rheum wittrochii (I). China. J. Chin. Mat. Med., 23: 417-424.

  388. Lu, P., K.K. Lu, J.H. Zheng and D.A. Guo, 1998. The effect of rare earth elements on cell and tissue cultures of Coptis chinensis. J. Beij. Med. Univ., 30: 389-391.

  389. Lu, P., J.H. Zheng, D.A. Guo and K.K. Lu, 1998. Quantitative determination of Berberine and jatrorrhizine in Callus of Coptis chinensis. China J. Pharm. Anal., 18: 101-104.

  390. Lu, K.K., Z.Z. Chang, D.Q. Pei, Z.Z. Chang, D.A. Guo and K. Wang, 1998. The effects of rare earth element on the growth of Rhubarb callus. Northwest Pharm. J., 13: 199-200.

  391. Lu, K.K., Z.Z. Chang, B.W. Chen, D.A. Guo, J.H. Zheng and K. Wang, 1998. Influence of rare earth elements on plant cell growth and morphology. J. Rare Earth, 16: 371-374.

  392. Lu, K.K., W.Y. Tong, R. Hu, D.A. Guo, J.H. Zheng and K. Wang, 1998. Studies on the chemical constituents of Rheum callus. China Trad. Herb. Drug, 29: 438-440.

  393. Liu, Y., D. Min, D. Huang, D.A. Guo and J.H. Zheng, 1998. Analysis of volatile constituents from Rheum wittrochii. J. Beij. Med. Univ., 30: 39-40.

  394. Lin, M., D. Min, D. Huang, D.A. Guo and J.H. Zheng, 1998. Quantification of amino acids in different parts of Rheum wittrochii. J. Beij. Med. Univ., 30: 29-30.

  395. Hu, J., P.F. Tu, D.A. Guo and J.H. Zheng, 1998. UV and TLC analytic identification of Genus Rheum. J. China Med. Mat., 21: 284-287.

  396. Han, J.Y., Z.Z. Zhang, Z.H. Peng, D.A. Guo, J.H. Zheng, 1998. Identification and quality analysis of cordyceps sinensis and its mycelium. J. Beij. Med. Univ., 30: 27-38.

  397. Guo, H.Z., Z.Z. Chang, R.J. Yang, D.A. Guo and J.H. Zheng, 1998. Anthraquinones from hairy root cultures of Cassia obtusifolia. Phytochemistry, 43: 1623-1625.
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  398. Guo, H.Z., D.A. Guo, X.Y. Fei, Y.J. Cui and J.H. Zheng, 1998. Biotransformation of podophyllotoxin to picropodophyllin by microbes. J. Asian Nat. Prod. Res., 1: 99-102.
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  400. Cui, Y.J., Y. Muhetar, S.J. Yue, J.H. Zheng and D.A. Guo, 1998. Studies on the volatile constituents of Rhodiola Rosea. J. Pek. Union Med. College, 18: 11-13.

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  402. Chang, Z.Z., X. Shen, D.A. Guo, S.S. Wang and J.H. Zheng, 1998. Comparison of anthraquinones in hairy roots, calli and suspension cells of Rheum palmatum. J. Beijing Med. Univ., 30: 500-502.

  403. Chang, Z.Z., L. Liu, D.A. Guo and J.H. Zheng, 1998. Analysis of anthraquinones by HPLC in Rheum tanguticum and Cassia obtussifolia. J. Beij. Med. Univ., 30: 35-38.

  404. Chang, Z.Z., D.A. Guo, X. Sheng, S.S. Wang and J.H. Zheng, 1998. Analysis of anthraquinones in hairy root cultures of Rheum palmatum. Acta Pharm. Sin., 33: 869-872.

  405. Chang, Z.Z., D.A. Guo and J.H.Zheng, 1998. Recent progress on bioactive natural compounds produced by Ri-lasmid transformed plants (I). Chin Trad. Herb. Drug, 29: 775-784.

  406. Chang, Z.Z., D.A. Guo and J.H. Zheng, 1998. Recent progress on bioactive natural compounds produced by Ri-lasmid transformed plants (I). China Trad. Herb. Drug, 29: 705-707.

  407. Chang, Z.Z. and D.A. Guo, R.A. Norton and J.H. Zheng, 1998. Sterol composition and biosynthesis in hairy root cultures of Cassia obtusifolia. China Trad. Herb. Drug, 29: 723-726.
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  408. An, F., S. Yue, D. Guo and J. Zheng, 1998. Determination of salidroside in eight Rhodiola species by TLC-UV spectrometry. China J. Chin. Mat. Med., 23: 43-44.
    PubMed  |  

  409. Tong, Y.S., B.S. McCourt, D.A. Guo, A.T. Mangla and W.X. Zhou et al., 1997. Stereochemical features of C-methylations on the path to Δ24(28)-methylene and Δ24(28)-ethylidene sterols: studies on the recombinant phytosterol methyl transferase from Arabidopsis thaliana. Tetrahedron Lett., 38: 6115-6118.

  410. Nes, W.D., M. Lopez, W. Zhou and D.A. Guo, 1997. Sterol utilization and metabolism by Heliothis zea. Lipids, 32: 1317-1323.
    CrossRef  |  Direct Link  |  

  411. Nes, W.D., D.A. Guo and W. Zhou, 1997. Substrate-based inhibitors of the S-adenosyl-L-methione: Δ24(25)-sterol methyl transferase from Saccharomyces cerevisiae. Arch. Biochem. Biophys., 342: 68-81.
    CrossRef  |  PubMed  |  Direct Link  |  

  412. Lu, K.K., Z.Z. Chang, B.W. Chen, D.A. Guo, J.H. Zheng and K. Wang, 1997. The hormone-like effect of rare earth elements on plant. J. Beij. Med. Univ., 29: 289-291.

  413. Hu, J., P.F. Tu, D.A. Guo and J.H. Zheng, 1997. Studies on the chemical constituents from Rheum qinlingense. Northwest Pharm. J., 12: 153-155.

  414. Guo, D.A., Z.G. Zhang, G.Q. Ye and Z.C. Lou, 1997. Studies on liposoluble constituents from the aerial parts of Siegesbeckia orientalis L. Acta Pharm. Sin., 32: 282-285.
    PubMed  |  

  415. Guo, D.A., Y.J. Cui, H.Z. Guo, J.H. Zheng and W.D. Nes, 1997. The biosynthesis of 24,25-epiminozymosterol and its inhibitory effect on 24,25-sterol methyl transterase. Northwest Pharm. J., 12: 132-133.

  416. Guo, D.A., J. Hu, Y.J. Cui, H.Z. Guo, J.H. Zheng and W.D. Nes, 1997. Biotransformation of 24-methylenecholesterol and sitosterol by yeast mutant GL-7. Northwest Pharm. J., 12: 174-176.
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  417. Guo, D.A., J. Hu, J.H. Zheng, S.A. Ross and W.D. Nes, 1997. Synthesis and characterization of 3-nitrogen substituted inhibitors of (S)-adenosyl-L-methionine: 24(25)-sterol methyl-transferase. J. China Pharm. Sci., 6: 133-137.

  418. Guo, D.A., D. Nichols, W. Zhou, Lopez, Z. Jia, A.T. Mangla and W.D. Nes, 1997. Antifungal Sterol Biosynthesis Inhibitors. In: Subcellular Biochemistry, Volume 28: Cholesterol: Its Metabolism and Function in Biology and Medicine, Brittman, R. (Ed.). Plenum Press, New York, USA., ISBN 978-0-306-45478-3, pp: 89-122.

  419. Fu, H.Z., Z.C. Lou, X.W. Yang, S.Q. Caiv and D.A. Guo, 1997. Studies of chemical constituents from Siegesbeckia pubescens Makino (I). China Trad. Herb. Drug, 5: 259-262.

  420. Zhou, W., D.A. Guo and W.D. Nes, 1996. Stereochemistry of hydrogen migration from C-24 to C-25 during biomethylation in ergosterol biosynthesis. Tetrahedron Lett., 37: 1339-1342.
    CrossRef  |  

  421. Venkatramesh, M., D.A. Guo, Z. Jia, W.D. Nes, 1996. Mechanism and structural requirements for transformation of substrates by the (S)-adenosyl-L-methionine: δ24(25)-sterol methyl transferase from Saccharomyces cerevisiae. Biochim. Biophys. Acta, 1299: 313-324.
    PubMed  |  

  422. Venkatramesh, M., D.A. Guo, J.G. Harman and W.D. Nes, 1996. Sterol specificity of the Saccharomyces cerevisiae ERG6 gene product expressed in Escherichia coli. Lipids, 31: 373-377.
    PubMed  |  

  423. Short, J.D., D.A. Guo, J.A. Svoboda and W.D. Nes, 1996. Mechanistic and metabolic studies of sterol 24, 25-double bond reduction in Manduca sexta. Arch. Insect Biochem. Physiol., 31: 1-22.
    CrossRef  |  

  424. Nes, W.D. and D.A. Guo, 1996. Rational design of antifungal agents. Information, 7: 866-868.

  425. Jia, Z.H., W. Zhou, D.A. Guo and W.D. Nes, 1996. Synthesis of rationally designed mechanism-based inactivators of the (S)-adenosyl-L-methionine: Δ24(25)-sterol methyl transferase. Syn. Commun., 26: 2758-2765.
    CrossRef  |  Direct Link  |  

  426. Guo, D.A., Z.H. Jia and W.D. Nes, 1996. Phytosterol biosynthesis: Isotope effects associated with biomethylation formation to 24-alkene sterol isomers. Tetrahedron Lett., 37: 6823-6826.
    CrossRef  |  Direct Link  |  

  427. Guo, D.A., Z.H. Jia and W.D. Nes, 1996. Mechanism of hydrogen migration from C-24 to C-25 during phytosterol biomethylation. J. Amer. Chem. Soc., 118: 8507-8508.

  428. Chang, Z.Z., K.K. Lu, D.A. Guo, J.H. Zheng and K. Wan, 1996. Hairy root cultures of Rheum palmatum and Cassia obtussifolia. J. Beij. Med. Univ., 28: 326-330.

  429. Lou, Z.C., D.A. Guo, S.H. Li and L.W. Shi, 1995. Studies on Loulu Crude Drugs. In: Species Systematization and Quality Evaluation of Commonly used Traditional Chinese Crude Drug, Lou, Z.C., B. Qin and D.A. Guo (Eds.). Beijing University of Medical Sciences and Peking Union Medical College Press, Beijing, China, pp: 639-709.

  430. Lou, Z.C., B. Qin and D.A. Guo, 1995. Species Systematization and Quality Evaluation of Commonly Used Traditional Chinese Crude Drugs. Beijing University of Medical Sciences and Peking Union Medical College Press, Beijing, China.

  431. Guo, D.A., M. Venkatramesh and W.D. Nes, 1995. Developmental regulation of sterol biosynthesis in Zea mays. Lipids, 30: 203-219.
    CrossRef  |  

  432. Guo, D.A. and W.D. Nes, 1995. Synthesis of rationally designed inhibitors of the S-adenosyl-L-methione: Δ24(25) -sterol methyl transferase. Syn. Commun., 25: 2623-2630.

  433. Ba, A.S., D.A. Guo, R.A. Norton, S.A. Phillips and W.D. Nes, 1995. Developmental differences in the sterol composition of Solenopsis invicta. Arch. Insect Biochem. Physiol., 29: 1-9.
    CrossRef  |  

  434. Guo, D.A., Z.C. Lou and Z.A. Liu, 1994. Studies on the volatile oil from the roots of Echinops grijisii, China. J. Chin. Mat. Med., 19: 100-100.

  435. Guo, D.A., S.H. Li and Z.C. Lou, 1994. Morphological and histilogical studies on Chinese crude drug Loulu. J. Chin. Pharm. Sci., 3: 18-30.

  436. Guo, D.A., X.Y Zhao and Z.C. Lou, 1993. The determination of scopolamine in zhichuangling injection. Chin Patent Med., 15: 44-44.

  437. An, F., S.J. Yue, D.A. Guo and Z.C. Lou, 1993. Resource investigation of Rhodiola plants in Sichuan Province China. J. Chin. Mat. Med., 18: 455-455.

  438. Guo, D.A., Z.C. Lou, C.Y. Gao, D. Wang and H.Y. Zhang, 1992. Studies on the lipophilic constituents of Rhaponticum uniflorum. Chin Trad Herb Drug, 23: 176-178.

  439. Guo, D.A., Z.C. Lou, C.Y. Gao and D. Wang, 1992. Studies on the chemical constituents of Echinops grijisii. Chin Trad Herb Drug, 23: 512-514.

  440. Guo, D.A., Z.A. Liu and Z.C. Lou, 1992. Constituents of Chinese drug fangfeng, the root of Saposhnikovia divaricata. J. China Pharm. Sci., 1: 81-83.

  441. Guo, D.A., Y.J. Cui, Z.C. Lou, C.Y. Gao and L.R. Huang, 1992. Studies on the chemical constituents of Echinops grijisii. Chin Trad Herb Drug, 23: 3-5.

  442. Guo, D.A., X.Y. Liu, L. Qiao, C.Y. Gao and Z.C. Lou, 1992. Chemical constituents of Echinops talassicus roots. J. Chinies Pharma. Sci., 1: 82-84.
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  443. Guo, D.A. and Z.C. Lou, 1992. Herbalogical study on Chinese drug Loulu. China J. Mat. Med., 17: 579-581.

  444. Guo, D.A., Z.C. Lou, C.Y. Gao, L. Qiao and J.R. Peng, 1991. Phytoecdysteroids of Rhaponticum uniflorum. Yao Xue Xue Bao, 26: 442-446.
    PubMed  |  

  445. Guo, D.A. and Z.C. Lou, 1991. Separation and quantitative determination of three phytoecdysteroids in rhaponticum uniflorum by high performance liquid chromatograghy. J. Chin. Pharm. Sci., 1: 60-66.
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  446. Gao, C.Y., D.A. Guo, L. Qiao, W.Y. He and Z.C. Lou, 1991. NMR study on the structure of a new phytosteroid. China J. Spectro, 8: 379-380.