Dr. Haiyun  Xu

Dr. Haiyun Xu

Professor
Shantou University Medical College, China


Highest Degree
Ph.D. in Neurosciences from Peking Union Medical College, China

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Biography

Dr. Haiyun Xu is currently working as Professor at Department of Anatomy and Mental Health Center, Shantou University Medical College. She obtained her PhD in Department of Anatomy from Peking Union Medical College, China in 1996. She is also working as Executive Director at University of Manitoba and member of Academic Committee of the Shantou University Medical College. Dr. Haiyun received honor includes, Laura E. Chapman Award, Saskatchewan Psychiatry Research Foundation, W.G. Dewhurst Award, Canadian College of Neuro Psychopharmacology, Molstad Trust Intramural Research Award, U of S, W.G. Dewhurst Award, CCNP, and Post Award Winner, Seroquel ISS Investigators Meeting. She is also member of editorial board in number of journals. She is also serving as reviewer of many journals. She also invited to deliver lecturers in several Institutes. She has published (47) articles in journals, (2) chapters in book, (43) presentations in conferences, and reviewer of (3) articles contributed as author/co-author.

Area of Interest:

Biomedical Sciences
100%
Neurobiology
62%
Neuroimage
90%
Neuropsychopharmacology
75%
Neuroscience
55%

Selected Publications

  1. Yang, P., Z. Gao, H. Zhang, Z. Fang, C. Wu, H. Xu and Q.J. Huang, 2015. Changes in proinflammatory cytokines and white matter in chronically stressed rats. Neuropsychiatr. Dis. Treatment, 11: 597-607.
    CrossRef  |  Direct Link  |  

  2. Shao, Y., G. Yan, Y. Xuan, H. Peng, Q.J. Huang, R. Wu and H. Xu, 2015. Chronic social isolation decreases glutamate and glutamine levels and induces oxidative stress in the rat hippocampus. Behav. Brain Res., 282: 201-208.
    CrossRef  |  Direct Link  |  

  3. Zhang, H., Y. Zhang, H. Xu, L. Wang and A. Adilijiang et al., 2014. Olanzapine ameliorates neuropathological changes and increases IGF-1 expression in frontal cortex of C57BL/6 mice exposed to cuprizone. Psychiatry Res., 216: 438-445.
    CrossRef  |  Direct Link  |  

  4. Yan, G., Y. Xuan, Z. Dai, Z. Shen, G. Zhang, H. Xu and R. Wu, 2014. Brain metabolite changes in subcortical regions after exposure to cuprizone for 6 weeks: Potential implications for schizophrenia. Neurochem. Res., 40: 49-58.
    CrossRef  |  

  5. Xuan, Y., G. Yan, H. Peng, R. Wu and H. Xum, 2014. Concurrent changes in 1H-MRS metabolites and antioxidant enzymes in the brain of C57BL/6 mouse short-termly exposed to cuprizone: Possible implications for schizophrenia. Neurochem. Int., 69: 20-27.
    CrossRef  |  Direct Link  |  

  6. Wang, J., Y. Zhang, H. Xu, S. Zhu and H. Wang et al., 2014. Fluoxetine improves behavioral performance by suppressing the production of soluble β-Amyloid in APP/PS1 mice. Curr. Alzheimer Res., 11: 672-680.
    Direct Link  |  

  7. Zhang, K., H. Xu, L. Cao, K. Li and Q. Huang, 2013. Interleukin-1β inhibits the differentiation of hippocampal neural precursor cells into serotonergic neurons. Brain Res., 1490: 193-201.
    CrossRef  |  

  8. Zhang, H., Y. Zhang, H. Xu, L. Wang and J. Zhao et al., 2013. Locomotor activity and anxiety status, but not spatial working memory are affected in mice after brief exposure to cuprizone. Neurosci. Bull., 29: 633-641.
    CrossRef  |  

  9. Xu, H., H.J. Yang and X.M. Li, 2013. Differential effects of antipsychotics on the development of rat oligodendrocyte precursor cells exposed to cuprizone. Eur. Arch. Psychiatry Clin. Neurosci. 10.1007/s00406-013-0414-3.
    CrossRef  |  

  10. Xu, H. and X.M. Li, 2013. The progresses in psychiatric research and prospects for their translation. Trans. Med. Res., 3: 12-33.

  11. Fang, F., H. Zhang, Y. Zhang, H. Xu and Q. Huang et al., 2013. Antipsychotics promote the differentiation of oligodendrocyte progenitor cells by regulating oligodendrocyte lineage transcription factors 1 and 2. Life Sci., 6: 429-434.
    CrossRef  |  

  12. Zhou, H., Q. Cheng, H.J. Yang and H.Y. Xu, 2012. A multi-scale Bayesian hypothesis testing approach for the analysis of prepulse inhibition test. AJMMS, 2: 80-84. 2012. A multi-scale Bayesian hypothesis testing approach for the analysis of prepulse inhibition test. AJMMS, 2: 80-84.
    CrossRef  |  

  13. Zhang, Y., H. Zhang, L. Wang, W. Jiang and H. Xu et al., 2012. Quetiapine enhances oligodendrocyte regeneration and myelin repair after cuprizone-induced demyelination. Schizphr. Res., 138: 8-17.
    CrossRef  |  

  14. Xu, H., H.J. Yang and G.M. Rose, 2012. Haloperidol-induced spatial memory deficits are accompanied with the upregulation of D1 and D2 receptors in the caudate putamen of C57BL/6 mouse. Life Sci., 91: 322-328.
    CrossRef  |  

  15. Chen, Z., H. Ye, H. Xu, S. An, A. Jin, C. Zhou and S. Yang, 2012. Rotating magnets produce prompt analgesia effect in rats. Prog. Electromag. Res., 27: 203-217.
    CrossRef  |  

  16. Zhou, H., Q. Cheng, H.J. Yang and H. Xu, 2011. Weighted kernel density estimation of the prepulse inhibition test. JCS, 7: 611-618.
    Direct Link  |  

  17. Yang, H.J., K. Wang, Q. Chen and H. Xu, 2011. Abnormal behaviors and micro-structural changes in white matter of juvenile mice repeatedly exposed to amphetamine. Schizophr. Res. Treatment. 10.1155/2011/542896.
    CrossRef  |  

  18. Xu, H., V. Haroutunian, G. Bartzokis and M.E. Shenton, 2011. Oligodendrocytes in schizophrenia. Schizophr. Res. Treatment. .
    Direct Link  |  

  19. Xu, H., H.J. Yang, G.M. Rose and X.M. Li, 2011. Recovery of behavioral changes and compromised white matter in C57BL/6 mice exposed to cuprizone: Effects of anti-psychotic drugs. Front. Behav. Neurosci., Vol. 5. 10.3389/fnbeh.2011.00031.
    CrossRef  |  

  20. Xu, H., H. Yang and G. Rose, 2011. Working Memory Deficits in Schizophrenia: Neuro-Biological Correlates and Treatment. In: Working Memory: Capacity, Developments and Improvement Techniques, Levin, E.S. (Ed.). Nova Publishers Inc., USA., pp: 313-344.

  21. Xu, H. and X.M. Li, 2011. White matter abnormalities and animal models examining a putative role of altered white matter in schizophrenia. Schizophr. Res. Treatment. 10.1155/2011/826976.
    CrossRef  |  

  22. Xu, H., H.J. Yang, B. McConomy, R. Browning and X.M. Li, 2010. Behavioral and neurobiological changes in C57BL/6 mouse exposed to cuprizone: Effects of antipsychotics. Front. Behav. Neurosci., Vol. 4. 10.3389/fnbeh.2010.00008.
    CrossRef  |  

  23. Wang, H., H. Xu, J. Niu, F. Mei and X.M. Li et al., 2010. Haloperidol activates quiescent oligodendroglia precursor cells in the adult mouse brain. Schizophr. Res., 119: 164-174.
    CrossRef  |  

  24. Fang, S., B. Yan, D. Wang, X. Bi and Y. Zhang et al., 2010. Chronic effects of venlafaxine on synaptophysin and neuronal cell adhesion molecule in the hippocampus of cerebral ischemic mice. Biochem. Cell. Biol., 88: 655-663.
    CrossRef  |  

  25. Yang, H.J., H. Wang, Y. Zhang, L. Xiao and R. Clough et al., 2009. Region-specific susceptibilities to cuprizone-induced lesions in the mouse forebrain: Implications for the pathophysiology of schizophrenia. Brain Res., 1270: 121-130.
    CrossRef  |  

  26. Xu, H., H.J. Yang, Y. Zhang, R. Clough, R. Browning and X.M. Li, 2009. Behavioral and neurobiological changes in C57BL/6 mice exposed to cuprizone. Behav. Neurosci., 123: 418-429.
    CrossRef  |  

  27. He, J., H. Luo, B. Yan, Y. Yu and H. Wang et al., 2009. Beneficial effects of quetiapine in a transgenic mouse model of Alzheimer's disease. Neurobiol. Aging, 30: 1205-1216.
    CrossRef  |  

  28. Zhang, Y., H. Xu, W. Jiang, L. Xiao and B. Yan et al., 2008. Quetiapine alleviates the cuprizone-induced demyelination and promotes the remyelination following withdrawal of cuprizone. Schizophr. Res., 106: 182-191.

  29. Xu, H., H. Wang, L. Zhuang, B. Yan and Y. Yu et al., 2008. Demonstration of an anti-oxidative stress mechanism of quetiapine: Implications for the treatment of Alzheimer's disease. FEBS J., 275: 3718-3728.
    CrossRef  |  Direct Link  |  

  30. Xiao, L., H. Xu, Y. Zhang, Z. Wei and J. He et al., 2008. Quetiapine facilitates oligodendrocyte development and prevents mice from myelin breakdown and behavioral changes. Mol. Psychiatry, 13: 697-708.
    CrossRef  |  PubMed  |  Direct Link  |  

  31. Zhang, Y., H. Xu, J. He, B. Yan, W. Jiang and X.M. Li, 2007. Quetiapine reverses altered locomotor activity and tyrosine hydroxylase immunoreactivity in rat caudate putamen following long-term haloperidol treatment. Neurosci. Lett., 420: 66-71.
    CrossRef  |  

  32. Yan, B., X. Bi, J. He, Y. Zhang and S. Thakur et al., 2007. Quetiapine attenuates spatial memory impairment and hippocampal neurodegeneration induced by bilateral common carotid artery occulusion in mice. Life Sci., 81: 353-361.
    CrossRef  |  

  33. Yan, B., J. He, H. Xu, Y. Zhang and X. Bi et al., 2007. Quetiapine attenuates the depressive and anxiolytic-like behavioural changes induced by global cerebral ischemia in mice. Behav. Brain Res., 182: 36-41.
    CrossRef  |  

  34. Xu, H. and X.M. Li, 2007. Cellular Metabolism. In: Psychiatric and Metabolic Disorders: Research Synthesis and Clinical Translation, McIntyre and Konarski (Eds.). Nova Publishers Inc., USA., pp: 57-73.

  35. Li, X.M. and H. Xu, 2007. In vitro and in vivo evidence for neuroprotective effects of antipsychotic drugs: Implications for the pathophysiology and treatment of schizophrenia. Int. Rev. Neurobiol., 77: 107-142.
    Direct Link  |  

  36. Xu, H., Z. Chen, J. He, S. Haimanot and X.M. Li, 2006. Quetiapine and venlafaxine share common actions on the hippocampal formation in rats exposed to chronic restraint stress. Hippocampus, 16: 551-559.

  37. He, J., H. Xu, Y. Yang, D. Rajakumar, X. Li and X.M. Li, 2006. The effects of chronic administration of quetiapine on the phencyclidine-induced reference memory impairment and decrease of Bcl-XL/Bax ratio in the posterior cingulate cortex in rats. Behav. Brain Res., 168: 236-242.
    CrossRef  |  

  38. Bai, O., H. Xu and X.M. Li, 2006. Haloperidol and atypical antipsychotics share a same action of decreasing p75NTR mRNA levels in PC12 cells. Life Sci., 79: 570-574.
    CrossRef  |  

  39. Wang, H., H. Xu, L. Dyck and X.M. Li, 2005. Atypical antipsychotics protect PC12 cells against amyloid-induced apoptosis by inhibiting oxidative stress. J. Neurosci. Res., 81: 572-580.

  40. Luo, C., H. Xu and X.M. Li, 2005. Quetiapine reverses the suppression of hippocampal neurogenesis caused by repeated restraint stress. Brain Res., 1063: 32-39.
    CrossRef  |  

  41. He, J., Y. Yang, H. Xu, X. Zhang and X.M. Li, 2005. Olanzapine attenuates the okadaic acid-induced spatial memory impairment and hippocampal cell death in rats. Neuropsychopharmacology, 30: 1511-1520.
    PubMed  |  

  42. He, J., H. Xu, Y. Yang, X. Zhang and X.M. Li, 2005. Chronic administration of quetiapine alleviates the anxiety-like behavioural changes induced by neurotoxic regimen of dl-amphetamine in rats. Behav. Brain Res., 160: 178-187.
    CrossRef  |  PubMed  |  

  43. Chen, Z., H. Xu, S. Haimanot, X. Li and X.M. Li, 2005. Quetiapine and venlafaxine synergically regulate heme oxygenase-2 protein expression in hippocampal formations of stressed rats. Neurosci. Lett., 389: 173-177.

  44. Xu, H., J.S. Richardson, C. Luo and X.M. Li, 2004. Recovery of hippocampal cell proliferation and BDNF levels, both of which are reduced by repeated restraint stress, is accelerated by chronic venlafaxine. Pharmacogenomics J., 4: 322-331.
    CrossRef  |  

  45. Xu, H., J. He, J.S. Richardson and X.M. Li, 2004. The response of synaptophysin and microtubule-associated protein 1 to restraint stress in rat hippocampus and its modulation by venlafaxine. J. Neurochem., 91: 1380-1388.
    CrossRef  |  

  46. Luo, C., H. Xu and X.M. Li, 2004. Post-stress changes in BDNF and Bcl-2 immuno-reactivities in hippocampal neurons: Effect of chronic administration of olanzapine. Brain Res., 1025: 194-202.
    CrossRef  |  

  47. He, J., H. Xu, Y. Yang, X. Zhang and X.M. Li, 2004. Neuroprotective effects of olanzapine on methamphetamine-induced neurotoxicity are associated with an inhibition of hyperthermia and prevention of Bcl-2 decrease in rats. Brain Res., 1018: 186-192.
    CrossRef  |  

  48. Xu, H., J.S. Richardson and X.M. Li, 2003. Dose-related effects of chronic antidepressants on the neuroprotective proteins BDNF, Bcl-2 and Cu/Zn-SOD in rat hippocampus. Neuropsychopharmacology, 28: 53-62.
    PubMed  |  

  49. Qing, H., H. Xu, Z. Wei, D. Gibson and X.M. Li, 2003. The ability of atypical antipsychotic drugs vs. haloperidol to protect PC12 cells against MPP+ -induced apoptosis. Eur. J. Neurosci., 17: 1563-1570.

  50. Xu, H., H. Qing, W. Lu, D. Keegan, J.S. Richardson, J. Chlan-Fourney and X.M. Li, 2002. Quetiapine attenuates the immobiliza-tion stress-induced decrease of brain-derived neurotrophic factor expression in rat hippocampus. Neurosci. Lett., 321: 65-68.
    CrossRef  |  

  51. Xu, H., S.J. Li, J. Bodurka, X. Zhao, Z.X. Xi and E.A. Stein, 2000. Heroin-induced neuronal activation in rat brain: Assessed by functional MRI. Neuroreport, 11: 1085-1092.
    PubMed  |  

  52. Bodurka, J., A. Jesmanowicz, J.S. Hyde, H. Xu, L. Estkowski and S.J. Li, 1999. Current-induced magnetic resonance phase imaging. J. Magnetic Resonance, 137: 265-271.
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  53. Wong-Riley, M., Z. Huang, W. Liebl, H. Xu and C. Zhang, 1998. Neurochemical organization of the macaque retina: Effect of TTX on levels and gene expression of cytochrome oxidase and nitric oxide synthase and on the immnoreactivity of Na+K+ ATPase and NMDA receptor subunit I. Vision Res., 38: 1455-1477.