Dr. Zhu Dan Yan
My Social Links

Dr. Zhu Dan Yan

Research Scientist
Zhejiang University, China

Highest Degree
M.D. in Pharmacology from Zhejiang University, China

Share this Profile

Area of Interest:

Pharmacology and Toxicology
100%
Stem Cell Biology
62%
Tissue Engineering
90%
Drug Regulation
75%
Chinese Traditional Medicine
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
0
Abstracts
0

Selected Publications

  1. Zhou, L.,Y. Huang, Y. Zhang, Q. Zhao, B. Zheng, Y. Lou and D. Zhu, 2013. mGluR5 stimulating Homer-PIKE formation initiates icariin induced cardiomyogenesis of mouse embryonic stem cells by activating reactive oxygen species. Exp. Cell Res., 319: 1505-1514.
    CrossRef  |  PubMed  |  Direct Link  |  
  2. Yan, J., Q. Liu, Y. Dou, Y. Hsieh and Y. Liu et al., 2013. Activating glucocorticoid receptor-ERK signaling pathway contributes to ginsenoside Rg1 protection against β-amyloid peptide-induced human endothelial cells apoptosis. J. Ethnopharmacol., 147: 456-466.
    CrossRef  |  PubMed  |  Direct Link  |  
  3. Zhu, D.Y., L.M. Zhou, Y.Y. Zhang, J.Q. Huang, X. Pan and Y.J. Lou, 2012. Involvement of metabotropic glutamate receptor 5 in cardiomyocyte differentiation from mouse embryonic stem cells. Stem Cells Dev., 21: 2130-2141.
    CrossRef  |  PubMed  |  Direct Link  |  
  4. Wu, J., Z. Pan, Z. Wang, W. Zhu and Y. Shen et al., 2012. Ginsenoside Rg1 protection against β-amyloid peptide-induced neuronal apoptosis via estrogen receptor α and glucocorticoid receptor-dependent anti-protein nitration pathway. Neuropharmacology, 63: 349-361.
    CrossRef  |  PubMed  |  Direct Link  |  
  5. Liang, X., Y. Mei, X. Huang, G. Shen and D. Zhu et al., 2012. Junctophilin 2 knockdown interfere with mitochondrium status in ESC-CMs and cardiogenesis of ES cells. J. Cell. Biochem., 113: 2884-2894.
    CrossRef  |  PubMed  |  Direct Link  |  
  6. Zhu, D.Y., R. Cui, Y.Y. Zhang, H. Li, L.M. Zhou and Y.J. Lou, 2011. Involvement of ubiquitin-proteasome system in icariin-induced cardiomyocyte differentiation of embryonic stem cells using two-dimensional gel electrophoresis. J. Cell. Biochem., 112: 3343-3353.
    CrossRef  |  PubMed  |  Direct Link  |  
  7. Yang, H., Y. Dou, X. Zheng, Y. Tan and J. Cheng et al., 2011. Cysteinyl leukotrienes synthesis is involved in aristolochic acid -induced apoptosis in renal proximal tubular epithelial cells. Toxicology, 287: 38-45.
    CrossRef  |  PubMed  |  Direct Link  |  
  8. Yan, J., Q. Shi, Z. Chen, R. Zhuang, H. Chen, D. Zhu and Y. Lou, 2011. Skeletal muscle aldolase an overexpression in endotoxemic rats and inhibited by GSNO via potential role for S-nitrosylation In vitro. J Surg. Res., 170: e57-e63.
    CrossRef  |  PubMed  |  Direct Link  |  
  9. Wang, D.Y., Y.Z. Hu, S.S. Kong, Y.P. Yu, D.Y. Zhu and Y.J. Lou, 2011. Promoting effects of isobavachin on neurogenesis of mouse embryonic stem cells were associated with protein prenylation. Acta Pharmacol. Sin., 32: 425-432.
    CrossRef  |  PubMed  |  Direct Link  |  
  10. Zhu, D.Y., J.Y. Wu, H. Li, J.P. Yan, M.Y. Guo, Y.B. Wo and Y.J. Lou, 2010. PPAR-β facilitating maturation of hepatic-like tissue derived from mouse embryonic stem cells accompanied by mitochondriogenesis and membrane potential retention. J. Cell. Biochem., 109: 498-508.
    CrossRef  |  PubMed  |  Direct Link  |  
  11. Ma, K., Y. Zhang, D. Zhu and Y. Lou, 2009. Protective effects of asiatic acid against D-galactosamine/lipopolysaccharide-induced hepatotoxicity in hepatocytes and kupffer cells co-cultured system via redox-regulated leukotriene C4 synthase expression pathway. Eur. J. Pharmacol., 603: 98-107.
    CrossRef  |  PubMed  |  Direct Link  |  
  12. Zhu, D.Y., Y. Du, X. Huang, M.Y. Guo, K.F. Ma, Y.P. Yu, Y.J. Lou, 2008. MAPEG expression in mouse embryonic stem cell-derived hepatic tissue system. Stem Cells Dev., 17: 775-784.
    CrossRef  |  PubMed  |  Direct Link  |  
  13. Wo, Y.B., D.Y. Zhu, Y. Hu, Z.Q. Wang, J. Liu and Y.J. Lou, 2008. Reactive oxygen species involved in prenylflavonoids, icariin and icaritin, initiating cardiac differentiation of mouse embryonic stem cells. J. Cell. Biochem., 103: 1536-1550.
    CrossRef  |  PubMed  |  Direct Link  |  
  14. Wo, Y., D. Zhu, Y. Yu and Y. Lou, 2008. Involvement of NF-κB and AP-1 activation in icariin promoted cardiac differentiation of mouse embryonic stem cells. Eur. J. Pharmacol., 586: 59-66.
    CrossRef  |  PubMed  |  Direct Link  |  
  15. Wang, Z., H. Wang, J. Wu, D. Zhu and X. Zhang et al., 2008. Enhanced co-expression of β-tubulin III and choline acetyltransferase in neurons from mouse embryonic stem cells promoted by icaritin in an estrogen receptor-independent manner. Chem. Biol. Interact., 179: 375-385.
    CrossRef  |  PubMed  |  Direct Link  |  
  16. Ma, K.F., H.Y. Yang, Z. Chen, L.Y. Qi, D.Y. Zhu and Y.J. Lou, 2008. Enhanced expressions and activations of leukotriene C4 synthesis enzymes in D-galactosamine/lipopolysaccharide-induced rat fulminant hepatic failure model. World J. Gastroenterol., 14: 2748-2756.
    CrossRef  |  PubMed  |  Direct Link  |  
  17. Ding, L., X.G. Liang, Y. Hu, D.Y. Zhu and Y.J. Lou, 2008. Involvement of p38MAPK and reactive oxygen species in icariin-induced cardiomyocyte differentiation of murine embryonic stem cells in vitro. Stem Cells Dev., 17: 751-760.
    CrossRef  |  PubMed  |  Direct Link  |  
  18. Zhu, D.Y., X.N. Zhang and Y. Du, 2007. Directed differentiation of mouse embryonic stem cells into neuronal cells induced by icaritin in vitro. J. Zhejiang Univ. (Med. Sci.), 36: 217-223.
    PubMed  |  Direct Link  |  
  19. Zhu, D.Y. and Y.J. Lou, 2007. A method of inducing directional differentiation of embryonic stem cells into cardiomyocytes in vitro. Chinese Pharma. J., 42: 667-671.
  20. Huang, X., D. Zhu and Y. Lou, 2007. A novel anticancer agent, icaritin, induced cell growth inhibition, G1 arrest and mitochondrial transmembrane potential drop in human prostate carcinoma PC-3 cells. Eur. J. Pharmacol., 564: 26-36.
    CrossRef  |  PubMed  |  Direct Link  |  
  21. Ding, L., X.G. Liang, D.Y. Zhu and Y.J. Lou, 2007. Peroxisome proliferator-activated receptor α is involved in cardiomyocyte differentiation of murine embryonic stem cells in vitro. Cell Biol. Int., 31: 1002-1009.
    CrossRef  |  PubMed  |  Direct Link  |  
  22. Ding, L., X.G. Liang, D.Y. Zhu and Y.J. Lou, 2007. Icariin promotes expression of PGC-1α, PPARα and NRF-1 during cardiomyocyte differentiation of murine embryonic stem cells in vitro. Acta Pharmacol. Sin., 28: 1541-1549.
    CrossRef  |  PubMed  |  Direct Link  |  
  23. Zhu, D.Y. and Y. Lou, 2006. Icariin-mediated expression of cardiac genes and modulation of nitric oxide signaling pathway during differentiation of mouse embryonic stem cells into cardiomyocytes in vitro. Acta Pharmacol. Sin., 27: 311-320.
    CrossRef  |  PubMed  |  Direct Link  |  
  24. Yang, B., Q.J. He, D.Y. Zhu, Y.J. Lou and R.Y. Fang, 2006. Antiproliferative activity of contragestazol (DL111-IT) in murine and human tumor models in vitro and in vivo. Cancer Chemother. Pharmacol., 57: 268-273.
    CrossRef  |  PubMed  |  Direct Link  |  
  25. Zhu, D.Y. and Y.J. Lou, 2005. Inducible effects of icariin, icaritin, and desmethylicaritin on directional differentiation of embryonic stem cells into cardiomyocytes in vitro. Acta Pharmacol. Sin., 26: 477-485.
    CrossRef  |  PubMed  |  Direct Link  |  
  26. Zhu, D., L. Qu, X. Zhang and Y. Lou, 2005. Icariin-mediated modulation of cell cycle and p53 during cardiomyocyte differentiation in embryonic stem cells. Eur. J. Pharmacol., 514: 99-110.
    CrossRef  |  PubMed  |  Direct Link  |