Dr. Weien  Yuan

Dr. Weien Yuan

Associate Professor
Shanghai Jiao Tong University, China


Highest Degree
M.D. in Pharmacy and Nanomedicine from Shanghai Jiao Tong University, China

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Area of Interest:

Pharmacology and Toxicology
100%
Nanomedicine
62%
Drug Design
90%
Pharmacy
75%
Neuroscience
55%

Education

2007

M.D.

Shanghai Jiao Tong University, China

Pharmacy and Nanomedicine

Selected Publications

  1. Zhao, H., F. Wu, Y. Cai, Y. Chen, L. Wei, Z. Liu and W. Yuan, 2013. Local antitumor effects of intratumoral delivery of rlL-2 loaded sustained-release dextran/PLGA-PLA core/shell microspheres. Int. J. Pharm., 450: 235-240.
    CrossRef  |  Direct Link  |  

  2. Xu, D., F. Wu, Y. Chen, L. Wei and W. Yuan, 2013. pH-sensitive degradable nanoparticles for highly efficient intracellular delivery of exogenous protein. Int. J. Nanomed., 8: 3405-3414.
    CrossRef  |  PubMed  |  

  3. Wu, N., L. Song, X. Yang, W. Yuan and Z. Liu, 2013. NMDA receptor regulation of levodopa-induced behavior and changes in striatal G protein-coupled receptor kinase 6 and β-arrestin-1 expression in parkinsonian rats. Clin. Int. Aging, 8: 347-352.
    CrossRef  |  PubMed  |  

  4. Wu, F., Z. Zhou, J. Su, L. Wei, W. Yuan and T. Jin, 2013. Development of dextran nanoparticles for stabilizing delicate proteins. Nanoscale Res. Lett., 8: 197-197.
    CrossRef  |  PubMed  |  

  5. Wei, L., F. Wu, D. Shi, C. Hu and X. Li et al., 2013. Spontaneous intercalation of long-chain alkyl ammonium into edge-selectively oxidized graphite to efficiently produce high-quality graphene. Sci. Rep., Vol. 3. 10.1038/srep02636.
    CrossRef  |  Direct Link  |  

  6. Ma, L., L. Wei, F. Wu, Z. Hu, Z. Liu and W. Yuan, 2013. Advances with microRNAs in Parkinson's disease research. Drug Des. Dev. Ther., 7: 1103-1113.
    CrossRef  |  PubMed  |  

  7. Ma, A., C. Wang, Y. Chen and W. Yuan, 2013. P-glycoprotein alters blood-brain barrier penetration of antiepileptic drugs in rats with medically intractable epilepsy. Drug Des. Dev. Ther., 7: 1447-1454.
    CrossRef  |  PubMed  |  

  8. Liang, D., X. Fu, M. Liao, W. Yuan and J. Su, 2013. Development of dextran microparticles loaded with IL-1Ra of high-encapsulation efficiency and high-bioactivity by a novel method without exposing IL-1Ra to water-oil interfaces. Powder Technol., 235: 299-302.
    CrossRef  |  Direct Link  |  

  9. Hong, X., L. Wei, F. Wu, Z. Wu, L. Chen, Z. Liu and W. Yuan, 2013. Dissolving and biodegradable microneedle technologies for transdermal sustained delivery of drug and vaccine. Drug Des. Dev. Ther., 7: 945-952.
    CrossRef  |  PubMed  |  

  10. Ge, X., Q. Zhang, Y. Cai, S. Duan and S. Chen et al., 2013. PEG-PCL-DEX polymersome-protamine vector as an efficient gene delivery system via PEG-guided self-assembly. Nanomedicine. 10.2217/nnm.13.83.
    CrossRef  |  PubMed  |  

  11. Chen, S., X. Ge, Y. Chen, N. Lv, Z. Liu and W. Yuan, 2013. Advances with RNA interference in Alzheimer's disease research. Drug Des. Dev. Ther., 7: 117-125.
    CrossRef  |  PubMed  |  

  12. Cai, Y.P., Y.G. Chen, X. Hong, Z. Liu and W. Yuan, 2013. Porous microsphere and its applications. Int. J. Nanomed., 8: 1111-1120.

  13. Cai, Y., L. Wei, L. Ma, X. Huang, A. Tao, Z. Liu and W. Yuan, 2013. Long acting preparations of exenatide. Drug Des. Dev. Ther., 7: 963-970.
    CrossRef  |  PubMed  |  

  14. Yuan, W., Z. Hu, J. Su, F. Wu, Z. Liu and T. Jin, 2012. Preparation and characterization of recombinant human growth hormone-Zn2+-dextran nanoparticles using aqueous phas-aqueous phase emulsion. Nanomedicine, 8: 424-427.
    CrossRef  |  PubMed  |  

  15. Yuan, W. and Z. Liu, 2012. Controlled-release and preserved bioactivity of proteins from (self-assembled) core-shell double-walled microspheres. Int. J. Nanomed., 7: 257-270.
    CrossRef  |  PubMed  |  

  16. Yuan, W. and Z. Liu, 2012. Controlled-release and preserved bioactivity of proteins from (self-assembled) core-shell double-walled microspheres. Int. J. Nanomed., 7: 257-270.
    CrossRef  |  PubMed  |  

  17. Yang, X., Y. Chen, X. Hong, N. Wu, L. Song, W. Yuan and Z. Liu, 2012. Levodopa/benserazide microspheres reduced levodopa-induced dyskinesia by downregulating phosphorylated GluR1 expression in 6-OHDA-lesioned rats. Drug Des. Dev. Ther., 6 : 341-347.
    CrossRef  |  PubMed  |  

  18. Yang, X., R. Zheng, Y. Cai, W. Yuan, M. Liao and Z. Liu, 2012. Controlled-release levodopa methyl ester/benserazide-loaded nanoparticles ameliorate levodopa-induced dyskinesia in rats. Int. J. Nanomed., 7: 2077-2086.
    CrossRef  |  PubMed  |  

  19. Yang, X., R. Zheng, Y. Cai, W. Yuan, M. Liao and Z. Liu, 2012. Controlled-release levodopa methyl ester/benserazide-loaded nanoparticles ameliorate levodopa-induced dyskinesia in rats. Int. J. Nanomed., 7: 2077-2086.
    CrossRef  |  PubMed  |  

  20. Yang, S., Y. Feng, L. Zhang, N. Chen, W. Yuan and T. Jin, 2012. A scalable fabrication process of polymer microneedles. Int. J. Nanomed., 7: 1415-1422.
    CrossRef  |  PubMed  |  

  21. Yang, S., Y. Feng, L. Zhang, N. Chen, W. Yuan and T. Jin, 2012. A scalable fabrication process of polymer microneedles. Int. J. Nanomed., 7: 1415-1422.
    CrossRef  |  PubMed  |  

  22. Xu, D., Z. Hu, J. Su, F. Wu and W. Yuan, 2012. Micro and nanotechnology for intracellular delivery therapy protein. Nano-Micro Lett., 4: 118-123.
    CrossRef  |  

  23. Xiang, S., J. Su, H. Tong, F. Yang and W. Tong et al., 2012. Biscarbamate cross-linked low molecular weight PEI for delivering IL-1 receptor antagonist gene to synoviocytes for arthritis therapy. Biomaterials, 33: 6520-6532.
    CrossRef  |  PubMed  |  

  24. Sun, W., Y. Chen and W. Yuan, 2012. Hemostatic absorbable gelatin sponge loaded with 5-fluorouracil for treatment of tumors. Int. J. Nanomed., 8: 1499-1506.
    CrossRef  |  PubMed  |  

  25. Rong, X., S. Yang, H. Miao, T. Guo and Z. Wang et al., 2012. Effects of erythropoietin-dextran microparticle-based PLGA/PLA microspheres on RGCs. Invest. Ophthalmol. Vis. Sci., 53: 6025-6034.
    CrossRef  |  PubMed  |  

  26. Ma, L., X. Hong, Z. Liu and W. Yuan, 2012. Stabilisation and encapsulation of protein into biodegradable microspheres with zinc ion and protein in polyethylene glycol solution formed nanoparticles by freeze-drying. Micro Nano Lett., 7: 215-218.
    CrossRef  |  Direct Link  |  

  27. Ma, L., X. Hong, Z. Liu and W. Yuan, 2012. Stabilisation and encapsulation of protein into biodegradable microspheres with zinc ion and protein in polyethylene glycol solution formed nanoparticles by freeze-drying. Micro Nano Lett., 7: 215-218.
    CrossRef  |  Direct Link  |  

  28. Liu, G., X. Hong, M. Jiang and W. Yuan, 2012. Sustained-release G-CSF microspheres using a novel solid-in-oil-in-oil-in-water emulsion method. Int. J. Nanomed., 7: 4559-4569.
    CrossRef  |  

  29. Liu, G., X. Hong, M. Jiang and W. Yuan, 2012. Preparation of bioactive interferon α-loaded polysaccharide nanoparticles using a new approach of temperature-induced water phase/water-phase emulsion. Int. J. Nanomed., 7: 4841-4848.
    CrossRef  |  PubMed  |  

  30. Hu, Z., M. Liao, Y. Chen, Y. Cai and L. Meng et al., 2012. A novel preparation method for silicone oil nanoemulsions and its application for coating hair with silicone. Int. J. Nanomed., 7: 5719-5924.
    CrossRef  |  PubMed  |  

  31. Duan, S., X. Ge, N. Lu, F. Wu, W. Yuan and T. Jin, 2012. Synthetic polyspermine imidazole-4, 5-amide as an efficient and cytotoxicity-free gene delivery system. Int. J. Nanomed., 7: 3813-3822.

  32. Duan, S., W. Yuan, F. Wu and T. Jin, 2012. Polyspermine imidazole-4,5-imine, a chemically dynamic and biologically responsive carrier system for intracellular delivery of siRNA. Angew. Chem. Int. Edn., 51: 7938-7941.
    CrossRef  |  Direct Link  |  

  33. Yuan, W. and Z. Liu, 2011. Surgical wound healing using hemostatic gauze scaffold loaded with nanoparticles containing sustained-release granulocyte colony-stimulating factor. Int. J. Nanomed., 6: 3139-3149.
    CrossRef  |  

  34. Yuan, W. and Z. Liu, 2011. Surgical wound healing using hemostatic gauze scaffold loaded with nanoparticles containing sustained-release granulocyte colony-stimulating factor. Int. J. Nanomed., 6: 3139-3149.
    CrossRef  |  

  35. Wu, F., W. Yuan, J. Su, J. Ren and T. Jin, 2011. Preparation and characterisation of PLGA microspheres for sustained release of recombinant human granulocyte colony-stimulating factor. Micro Nano Lett., 6: 181-185.
    CrossRef  |  Direct Link  |  

  36. Wu, F., W. Yuan, J. Su, J. Ren and T. Jin, 2011. Preparation and characterisation of PLGA microspheres for sustained release of recombinant human granulocyte colony-stimulating factor. Micro Nano Lett., 6: 181-185.
    CrossRef  |  Direct Link  |  

  37. Rong, X., X. Mo, T. Ren, S. Yang and W. Yuan et al., 2011. Neuroprotective effect of erythropoietin-loaded composite microspheres on retinal ganglion cells in rats. Eur. J. Pharm. Sci., 43: 334-342.
    CrossRef  |  PubMed  |  

  38. Rong, X., X. Mo, T. Ren, S. Yang and W. Yuan et al., 2011. Neuroprotective effect of erythropoietin-loaded composite microspheres on retinal ganglion cells in rats. Eur. J. Pharm. Sci., 43: 334-342.
    CrossRef  |  PubMed  |  

  39. Ren, T., X. Yang, N. Wu, Y. Cai, Z. Liu and W. Yuan, 2011. Sustained-release formulation of levodopa methyl ester/benserazide for prolonged suppressing dyskinesia expression in 6-OHDA-leisoned rats. Neurosci. Lett., 502: 117-122.
    CrossRef  |  PubMed  |  

  40. Ren, T., X. Yang, N. Wu, Y. Cai, Z. Liu and W. Yuan, 2011. Sustained-release formulation of levodopa methyl ester/benserazide for prolonged suppressing dyskinesia expression in 6-OHDA-leisoned rats. Neurosci. Lett., 502: 117-122.
    CrossRef  |  PubMed  |  

  41. Ren, T., W. Yuan, H. Zhao and T. Jin, 2011. Sustained-release polylactide-co-glycolide microspheres loaded with pre-formulated protein polysaccharide nanoparticles. Micro Nano Lett., 6: 70-74.
    CrossRef  |  

  42. Ren, T., W. Yuan, H. Zhao and T. Jin, 2011. Sustained-release polylactide-co-glycolide microspheres loaded with pre-formulated protein polysaccharide nanoparticles. Micro Nano Lett., 6: 70-74.
    CrossRef  |  

  43. Hu, Z., Y. Liu, W. Yuan, F. Wu, J. Su and T. Jin, 2011. Effect of bases with different solubility on the release behavior of risperidone loaded PLGA microspheres. Colloids Surf. B, 86: 206-211.
    CrossRef  |  Direct Link  |  

  44. Hu, Z., Y. Liu, W. Yuan, F. Wu, J. Su and T. Jin, 2011. Effect of bases with different solubility on the release behavior of risperidone loaded PLGA microspheres. Colloids Surf. B, 86: 206-211.
    CrossRef  |  Direct Link  |  

  45. Zhang, Y., F. Wu, W. Yuan and T. Jin, 2010. Polymersomes of asymmetric bilayer membrane formed by phase-guided assembly. J. Control Release, 147: 413-419.
    CrossRef  |  PubMed  |  

  46. Zhang, Y., F. Wu, W. Yuan and T. Jin, 2010. Polymersomes of asymmetric bilayer membrane formed by phase-guided assembly. J. Control Release, 147: 413-419.
    CrossRef  |  PubMed  |  

  47. Yuan, W., Y. Zhang, F. Wu, H. Li and Y. Cai et al., 2010. Preparation of protein-loaded sustained-release microspheres via solid-in-oil-in-hydrophilic oil-in-ethanol (S/O/hO/E) emulsification. Colloids Surf. B., 79: 326-333.
    CrossRef  |  PubMed  |  

  48. Yuan, W., Y. Zhang, F. Wu, H. Li and Y. Cai et al., 2010. Preparation of protein-loaded sustained-release microspheres via solid-in-oil-in-hydrophilic oil-in-ethanol (S/O/hO/E) emulsification. Colloids Surf. B., 79: 326-333.
    CrossRef  |  PubMed  |  

  49. Yuan, W., T. Ren, F. Wu, H. Zhao and T. Jin, 2010. A novel preparation method for microspheres by glycerol modified solid-in-oil-in-water multi-emulsion. Polym. Adv. Technol., 21: 371-376.
    CrossRef  |  Direct Link  |  

  50. Yuan, W., T. Ren, F. Wu, H. Zhao and T. Jin, 2010. A novel preparation method for microspheres by glycerol modified solid-in-oil-in-water multi-emulsion. Polym. Adv. Technol., 21: 371-376.
    CrossRef  |  Direct Link  |  

  51. Yang, X., W. Yuan, T. Ren, L. Song, N. Wu and Z. Liu, 2010. Levodopa/benserazide-loaded biodegradable microspheres reduce dyskinesia in rats. NeuroReport, 21: 837-840.
    CrossRef  |  PubMed  |  

  52. Yang, X., W. Yuan, T. Ren, L. Song, N. Wu and Z. Liu, 2010. Levodopa/benserazide-loaded biodegradable microspheres reduce dyskinesia in rats. NeuroReport, 21: 837-840.
    CrossRef  |  PubMed  |  

  53. Yuan, W., Y. Geng, F. Wu, Y. Liu, M. Guo, H. Zhao and T. Jin, 2009. Preparation of polysaccharide glassy microparticles with stabilization of proteins. Int. J. Pharm., 366 : 154-159.
    CrossRef  |  PubMed  |  

  54. Yuan, W., Y. Geng, F. Wu, Y. Liu, M. Guo, H. Zhao and T. Jin, 2009. Preparation of polysaccharide glassy microparticles with stabilization of proteins. Int. J. Pharm., 366 : 154-159.
    CrossRef  |  PubMed  |  

  55. Yuan, W., F. Wu, M. Guo and T. Jin, 2009. Development of protein delivery microsphere system by a novel S/O/O/W multi-emulsion. Eur. J. Pharm. Sci., 36: 212-218.
    CrossRef  |  PubMed  |  

  56. Yuan, W., F. Wu, M. Guo and T. Jin, 2009. Development of protein delivery microsphere system by a novel S/O/O/W multi-emulsion. Eur. J. Pharm. Sci., 36: 212-218.
    CrossRef  |  PubMed  |  

  57. Yuan, W., F. Wu and T. Jin, 2009. Microencapsulation of protein-loaded polysaccharide particles within poly(D,L-lactic-co-glycolic acid) microspheres using S/O/W: Characterization and release studies. Polym. Adv. Technol., 20: 834-842.
    CrossRef  |  Direct Link  |  

  58. Yuan, W., F. Wu and T. Jin, 2009. Microencapsulation of protein-loaded polysaccharide particles within poly(D,L-lactic-co-glycolic acid) microspheres using S/O/W: Characterization and release studies. Polym. Adv. Technol., 20: 834-842.
    CrossRef  |  Direct Link  |  

  59. Yang, S., W. Yuan and T. Jin, 2009. Formulating protein therapeutics into particulate forms. Expert Opin. Drug Deliv., 6: 1123-1133.
    CrossRef  |  PubMed  |  

  60. Yang, S., W. Yuan and T. Jin, 2009. Formulating protein therapeutics into particulate forms. Expert Opin. Drug Deliv., 6: 1123-1133.
    CrossRef  |  PubMed  |  

  61. Xu, L., F. Wu, W. Yuan and T. Jin, 2008. Controlled-release implant system formulated using biodegradable hemostatic gauze as Scaffold. Int. J. Pharm., 355: 249-258.
    CrossRef  |  PubMed  |  

  62. Xu, L., F. Wu, W. Yuan and T. Jin, 2008. Controlled-release implant system formulated using biodegradable hemostatic gauze as Scaffold. Int. J. Pharm., 355: 249-258.
    CrossRef  |  PubMed  |  

  63. Jin, T., J. Zhu, F. Wu, W. Yuan, L.L. Geng and H. Zhu, 2008. Preparing polymer-based sustained-release systems without exposing proteins to water-oil or water-air interfaces and cross-linking reagents. J. Control Release, 128: 50-59.
    CrossRef  |  PubMed  |  

  64. Jin, T., J. Zhu, F. Wu, W. Yuan, L.L. Geng and H. Zhu, 2008. Preparing polymer-based sustained-release systems without exposing proteins to water-oil or water-air interfaces and cross-linking reagents. J. Control Release, 128: 50-59.
    CrossRef  |  PubMed  |  

  65. Geng, Y., W. Yuan, F. Wu, J. Chen, M. He and T. Jin, 2008. Formulating erythropoietin-loaded sustained-release PLGA microspheres without protein aggregation. J. Control Release, 130: 259-265.
    CrossRef  |  PubMed  |  

  66. Geng, Y., W. Yuan, F. Wu, J. Chen, M. He and T. Jin, 2008. Formulating erythropoietin-loaded sustained-release PLGA microspheres without protein aggregation. J. Control Release, 130: 259-265.
    CrossRef  |  PubMed  |  

  67. Yuan, W., F. Wu, Y. Geng, S. Xu and T. Jin, 2007. Preparation of dextran glassy particles through freezing-induced phase separation. Int. J. Pharm., 339: 76-83.
    CrossRef  |  PubMed  |  Direct Link  |  

  68. Yuan, W., F. Wu, Y. Geng, S. Xu and T. Jin, 2007. Preparation of dextran glassy particles through freezing-induced phase separation. Int. J. Pharm., 339: 76-83.
    CrossRef  |  PubMed  |  Direct Link  |  

  69. Yuan, W., F. Wu, Y. Geng, S. Xu and T. Jin, 2007. An effective approach to prepare uniform protein-Zn2+ nanoparticles under mild conditions. Nanotechnology, Vol. 18. 10.1088/0957-4484/18/14/145601.
    CrossRef  |  

  70. Yuan, W., F. Wu, Y. Geng, S. Xu and T. Jin, 2007. An effective approach to prepare uniform protein-Zn2+ nanoparticles under mild conditions. Nanotechnology, Vol. 18. 10.1088/0957-4484/18/14/145601.
    CrossRef  |