Dr. Shougang  Zhuang

Dr. Shougang Zhuang

Professor
Tongji University School of Medicine, China


Highest Degree
Ph.D. in Medical Science from Yokohama City University, Japan

Share this Profile

Area of Interest:

Medicine
100%
Biomedical Engineering
62%
Cell Physiology
90%
Oncogene
75%
Biological Chemistry
55%

Education

1997

Ph.D.

Yokohama City University, Japan

Medical Science

Selected Publications

  1. Zhuang, S., 2013. Regulation of STAT signaling by acetylation. Cell. Signal., 25: 1924-1931.
    CrossRef  |  Direct Link  |  

  2. Zhao, T.C., J. Du, S. Zhuang, P. Liu and L.X. Zhang, 2013. HDAC inhibition elicits myocardial protective effect through modulation of MKK3/Akt-1. PloS One, Vol. 8. 10.1371/journal.pone.0065474.
    CrossRef  |  PubMed  |  Direct Link  |  

  3. Tang, J., Y. Yan, T.C. Zhao, G. Bayliss, H. Yan and S. Zhuang, 2013. Class I histone deacetylase activity is required for proliferation of renal epithelial cells. Am. J. Physiol. Renal Physiol., 305: F244-F254.
    CrossRef  |  PubMed  |  Direct Link  |  

  4. Tang, J., N. Liu, E. Tolbert, M. Ponnusamy and L. Ma et al., 2013. Sustained activation of EGFR triggers renal fibrogenesis after acute kidney injury. Am. J. Pathol., 183: 160-172.
    CrossRef  |  PubMed  |  Direct Link  |  

  5. Tang, J., N. Liu and S. Zhuang, 2013. Role of epidermal growth factor receptor in acute and chronic kidney injury. Kidney Int., 83: 804-810.
    CrossRef  |  Direct Link  |  

  6. Tang, J., H. Yan and S. Zhuang, 2013. Histone deacetylses as trargets for treatment of various diseases. Clin. Sci. (Lond.), 124: 651-662.

  7. Si, J., Y. Ge, S. Zhuang, L.J. Wang, S. Chen and R. Gong, 2013. Adrenocorticotropic hormone ameliorates acute kidney injury by steroidogenic-dependent and independent mechanisms. Kidney Int., 83: 635-646.
    CrossRef  |  Direct Link  |  

  8. Ponnusamy, M., L. Ma and S. Zhuang, 2013. Necrotic renal epithelial cell inhibits renal interstitial fibroblast activation: Role of protein tyrosine phosphatase 1B. Am. J. Physiol. Renal Physiol., 304: F698-F709.
    CrossRef  |  PubMed  |  Direct Link  |  

  9. Ma, S.C., N. Liu, Y. Lan, S.G. Zhuang and H.D. Yan, 2013. Effect of suramin on the epithelial-mesenchymal transition in peritoneal mesothelial cells induced by high concentration glucose. Chin. J. Nephrol., 29: 142-146.
    Direct Link  |  

  10. Liu, N., S. He, L. Ma, M. Ponnusamy and J. Tang et al., 2013. Blocking the class I histone deacetylase ameliorates renal fibrosis and inhibits renal fibroblast activation via modulating TGF-Β and EGFR signaling. PloS One, Vol. 8. 10.1371/journal.pone.0054001.
    CrossRef  |  Direct Link  |  

  11. Liu, N., L. Fang, H. Yang and S. Zhuang, 2013. The role and mechanism of histone deacetylases in regulating progression of kidney diseases. Chin. J. Nephrol., 29: 72-75.

  12. Li, X. and S. Zhuang, 2013. Acute kidney injury in HIV infection. J. Trop. Dis., 1: 101-101.
    CrossRef  |  Direct Link  |  

  13. He, S., N. Liu, G. Bayliss and S. Zhuang, 2013. EGFR activity is required for renal tubular cell dedifferentiation and proliferation in a murine model of folic acid-induced acute kidney injury. Am. J. Physiol. Renal Physiol., 304: F356-F366.
    CrossRef  |  PubMed  |  Direct Link  |  

  14. Zhuang, S., M. Duan and Y. Yan, 2012. Src family kinases regulate renal epithelial dedifferentiation through activation of EGFR/PI3K signaling. J. Cell. Physiol., 227: 2138-2144.
    CrossRef  |  PubMed  |  Direct Link  |  

  15. Zhang, X.T. and S. Zhuang, 2012. Clinical application of nocturnal hemodialysis. Chin. J. Nephrol. Dial Trans., 21: 179-182.

  16. Zhang, L., X. Qin, Y. Zhao, L. Fast and S. Zhuang et al., 2012. Inhibition of histone deacetylases preserves myocardial performance and prevents cardiac remodeling through stimulation of endogenous angiomyogenesis. J. Pharmacol. Exp. Ther., 341: 285-293.
    CrossRef  |  PubMed  |  

  17. Wang, J., S. Liu, X. Li, H. Qi, S. Zhuang and H. Yan, 2012. Effects of different dialyzers on oxidative stress for maintenance hemodialysis patients. Shanghai Med. J., 35: 134-137.

  18. Tang, J., H. Yan and S. Zhuang, 2012. Inflammation and oxidative stress in obesity-related glomerulopathy. Int. J. Nephrol., Vol. 2012. 10.1155/2012/608397.
    CrossRef  |  Direct Link  |  

  19. Ponnusamy, M., N. Liu, R. Sellamuthu, T.C. Zhao, H. Mao and S. Zhuang, 2012. Autophagy protects against necrotic renal epithelial cell-induced death of renal interstitial fibroblasts. Am. J. Physiol. Renal Physiol., 303: F83-F91.
    CrossRef  |  PubMed  |  Direct Link  |  

  20. Ma, S., H. Yan, S. Zhuang, Y. Lan, R. Zhang and Y. Wang, 2012. Establishment of method for primary culture and passage of rat peritoneal mesothelial cells. J. Tonji Univ. (Med. Sci.), 33: 392-395.

  21. Liu, N., S. He, E. Tolbert, R. Gong, G. Bayliss and S. Zhuang, 2012. Suramin alleviates glomerular injury and inflammation in the remnant kidney. PLoS One, Vol. 7. 10.1371/journal.pone.0036194.
    CrossRef  |  Direct Link  |  

  22. Liu, N., J.K. Guo, M. Pang, E. Tolbert and M. Ponnusamy et al., 2012. Genetic or pharmacologic blockade of EGFR inhibits renal fibrosis. J. Am. Soc. Nephrol., 23: 854-867.
    CrossRef  |  PubMed  |  

  23. Lan, Y.,H. Qi,S. Zhuang and H. Yan, 2012. Application of sodium citrate combined with modified dialysate in continuous venous-venous hemodialysis. Shanghai Med. J., 35: 112-115.

  24. Jiang, W., H. Yan and S. Zhuang, 2012. Update on cardiorenal syndrome. Chin. J. Nephrol., 28: 151-154.

  25. Bao, H., Z. Liu, Y. Ge, S.M. Yang and S. Zhuang et al., 2012. Protection against NSAID induced acute kidney injury by GSK3β inhibition: effects on mitochondrial permeability transition and ATP production. Kidney Int., 81: 662-673.

  26. Zhuang, S. and H. Yan, 2011. Bilingual Manual of Nephrology. Shanghai Xuelin Publishing House, Shanghai, China.

  27. Zhang, R.Q., S. Zhuang and H. Yang, 2011. Recent advances in peritoneal dialysis. Chin. J. Blood Purif., 11: 218-222.

  28. Ponnusamy, M., N. Liu, R. Gong, H. Yan and S. Zhuang, 2011. ERK pathway mediates P2X7 expression and cell death in renal interstitial fibroblasts exposed to necrotic renal epithelial cells. Am. J. Physiol. Renal Physiol., 301: F650-F659.
    CrossRef  |  PubMed  |  Direct Link  |  

  29. Ponnusamy, M., L. Ma, R. Gong, M. Pang, Y.E. Chin and S. Zhuang, 2011. P2x7 receptors mediate deleterious renal epithelial-fibroblast cross talk. Am. J. Physiol. Renal Physiol., 300: F62-F70.
    CrossRef  |  PubMed  |  Direct Link  |  

  30. Pang, M., L. Ma, N. Liu, M. Ponnusamy, T.C. Zhao, H. Yan and S. Zhuang, 2011. Histone deacetylase 1/2 mediates proliferation of renal interstitial fibroblasts and expression of cell cycle proteins. J. Cell. Biochem., 112: 2138-2148.
    CrossRef  |  PubMed  |  Direct Link  |  

  31. Ma, L. and S. Zhuang, 2011. The role of STAT 3 in tissue fibrosis. Curr. Chem. Biol., 5: 44-51.
    CrossRef  |  Direct Link  |  

  32. Liu, N., E. Tolbert, M. Ponnusamy, H. Yan and S. Zhuang, 2011. Delayed administration of suramin attenuates the progression of renal fibrosis in obstructive nephropathy. J. Pharmacol. Exp. Ther., 338: 758-766.
    CrossRef  |  PubMed  |  

  33. Liu, N., E. Tolbert, M. Pang, M. Ponnusamy, H. Yan and S. Zhuang, 2011. Suramin inhibits renal fibrosis in chronic kidney disease. J. Am. Soc. Nephrol., 22: 1064-1075.
    CrossRef  |  PubMed  |  Direct Link  |  

  34. Liu, N. and S. Zhuang, 2011. Tissue protective and anti-fibrotic actions of suramin: New uses of an old drug. Curr. Clin. Pharmacol., 6: 137-142.
    CrossRef  |  PubMed  |  

  35. Li, X., J. Wang, H. Yan and S. Zhuang, 2011. α-lipoic acid attenuates TGF-β1 and CTGF overexpression in STZ-induced diabetic nephropathy. J. Tongji Univ. (Med. Sci.), 32: 92-95.

  36. Li, S., Y. Zhou, J. Fan, S. Cao and T. Cao et al., 2011. Heat shock protein 72 enhances autophagy as a protective mechanism in lipopolysaccharide-induced peritonitis in rats. Am. J. Pathol., 179: 2822-2834.
    CrossRef  |  PubMed  |  Direct Link  |  

  37. Guan, Y.J., Z. Zhang, C. Yu, L. Ma and W. Hu et al., 2011. Phospho-SXXE/D motif mediated TNF receptor 1-TRADD death domain complex formation for T cell activation and migration. J. Immunol., 187: 1289-1297.
    CrossRef  |  PubMed  |  

  38. Ge, Y., J. Si, L. Tian, S. Zhuang, L.D. Dworkin and R. Gong, 2011. Conditional ablation of glycogen synthase kinase 3β in postnatal mouse kidney. Lab. Invest., 91: 85-96.
    CrossRef  |  PubMed  |  Direct Link  |  

  39. Chen, H.P., M. DeNicola, X. Qin, Y. Zhao and L. Zhang et al., 2011. HDAC inhibition promotes cardiogenesis and the survival of embryonic stem cells through proteasome-dependent pathway. J. Cell. Biochem., 112: 3246-3255.
    CrossRef  |  PubMed  |  Direct Link  |  

  40. Zhuang, S., 2010. Renal Failure-Related Sleep Apnea Syndrome. In: Blood Purification, Wang, Z. (Ed.) 3rd Edn., Beijing Sciences and Technology Publishing House, Beijing, China.

  41. Zhou, Y., H. Mao, S. Li, S. Cao and Z. Li et al., 2010. HSP72 inhibits Smad3 Activation and nuclear translocation in renal epithelial-to-mesenchymal transition. J. Am. Soc. Nephrol., 21: 598-609.
    CrossRef  |  Direct Link  |  

  42. Si, J., Y. Ge, S. Zhuang and R. Gong, 2010. Inhibiting nonmuscle myosin II impedes inflammatory infiltration and ameliorates progressive renal disease. Lab. Inves., 90: 448-458.
    CrossRef  |  PubMed  |  Direct Link  |  

  43. Pang, M., L. Ma, R. Gong, E. Tolbert and H. Mao et al., 2010. A novel STAT3 inhibitor, S3I-201, attenuates renal interstitial fibroblast activation and interstitial fibrosis in obstructive nephropathy. Kidney Int., 78: 257-268.
    CrossRef  |  PubMed  |  Direct Link  |  

  44. Pang, M. and S. Zhuang, 2010. Histone deacetylase: A potential therapeutic target for fibrotic disorders. J. Pharmacol. Exp. Ther., 335: 266-272.
    CrossRef  |  PubMed  |  

  45. Ma, L., J.S. Gao, Y.J. Guan, X. Shi and H. Zhang et al., 2010. Acetylation modulates prolactin receptor dimerization. Proc. Natl. Acad. Sci., 107: 19314-19319.
    CrossRef  |  PubMed  |  Direct Link  |  

  46. Zhuang, S., B. Lu, R.A. Daubert, K.D. Chavin, L. Wang and R.G. Schnellmann, 2009. Suramin promotes recovery from renal ischemia/reperfusion injury in mice. Kidney Int., 75: 304-311.
    CrossRef  |  PubMed  |  Direct Link  |  

  47. Zhuang, S., B. Lu and M. Pang, 2009. Postconditioning does not improve renal function or attenuate tubular damage in ischemia/reperfusion-induced acute kidney injury in mice. Open Pathol. J., 4: 18-21.
    Direct Link  |  

  48. Zhang, Z., J. Xing, L. Ma, R. Gong, Y.E. Chin and S. Zhuang, 2009. Transglutaminase-1 regulates renal epithelial cell proliferation through activation of Stat-3. J. Biol. Chem., 284: 3345-3353.
    CrossRef  |  

  49. Pang, M., J. Kothapally, H. Mao, E. Tolbert, M. Ponnusamy, Y.E. Chin and S. Zhuang, 2009. Inhibition of histone deacetylase activity attenuates renal fibroblast activation and interstitial fibrosis in obstructive nephropathy. Am. J. Physiol. Renal Physiol., 297: F996-F1005.
    CrossRef  |  PubMed  |  Direct Link  |  

  50. Murugavel, P., M. Pang, P.K. Annamaraju, Z. Zhang, R. Gong, Y.E. Chin and S. Zhuang, 2009. Transglutaminase-1 protects renal epithelial cells from oxidant-induced apoptosis through activation of Stat3 and Akt signaling pathways. Am. J. Physiol. Renal Physiol., 297: F1361-F1370.

  51. Zhuang, S., R.K. Gilbert, Y. Yan, J. Han and R.G. Schnellmann, 2008. ERK activation mediates mitochondria dysfunction and necrosis induced by hydrogen peroxide in renal proximal tubular cells. J. Pharmacol. Exp. Ther., 325: 732-740.

  52. Zhuang, S., G.R. Kinsey, K. Rasbach and R.G. Schnellmann, 2008. Heparin-binding epidermal growth factor and Src family kinases in proliferation of renal epithelial cells. Am. J. Physiol. Renal Physiol., 294: F459-F468.
    CrossRef  |  PubMed  |  Direct Link  |  

  53. Xing, J., Z. Zhang, H. Mao, R.G. Schnellmann and S. Zhuang, 2008. Src regulates cell cycle protein expression and renal epithelial cell proliferation via PI3K/Akt signaling-dependent and -independent mechanisms. Am. J. Physiol. Renal Physiol., 295: F145-F152.
    CrossRef  |  PubMed  |  Direct Link  |  

  54. Mao, H., Z. Li, Y. Zhou, Z. Li and S. Zhuang et al., 2008. HSP72 attenuates renal tubular cell apoptosis and interstitial fibrosis in obstructive nephropathy. Am. J. Physiol. Renal Physiol., 295: F202-F214.
    CrossRef  |  PubMed  |  Direct Link  |  

  55. Hallman, M.A., S. Zhuang and R.G. Schnellmann, 2008. Regulation of dedifferentiation and redifferentiation in renal proximal tubular cells by the epidermal growth factor receptor. J. Pharmacol. Exp. Ther., 325: 520-528.
    CrossRef  |  PubMed  |  Direct Link  |  

  56. Zhuang, S., Y. Yan, R.A. Daubert, J. Han and G.R. Schnellmann, 2007. ERK promotes hydrogen peroxide-induced apoptosis through caspase-3 activation and inhibition of Akt in renal epithelial cells. Am. J. Physiol. Renal Physiol., 292: F440-F447.
    CrossRef  |  PubMed  |  Direct Link  |  

  57. Zhuang, S., Y. Yan, R.A. Daubert and R.G. Schnellmann, 2007. Epiregulin promotes proliferation and migration of renal proximal tubular cells. Am. J. Physiol. Renal Physiol., 293: F219-F226.
    CrossRef  |  PubMed  |  Direct Link  |  

  58. Gao, B., J. Yang, S. Zhuang, Y. Deng and W. Yang et al., 2007. Mollaret meningitis associated with an intraspinal epidermoid cyst. Pediatrics, 120: e220-e224.
    CrossRef  |  PubMed  |  Direct Link  |  

  59. Zhuang, S. and R.G. Schnellmann, 2006. A death-promoting role for extracellular signal-regulated kinase. J. Pharmacol. Exp. Ther., 319: 991-997.
    PubMed  |  

  60. Zhuang, S., Y. Yan, J. Han and R.G. Schnellmann, 2005. p38 kinase-mediated transactivation of the epidermal growth factor receptor is required for dedifferentiation of renal epithelial cells after oxidant injury. J. Biol. Chem., 280: 21036-21042.
    CrossRef  |  PubMed  |  Direct Link  |  

  61. Zhuang, S. and R.G. Schnellmann, 2005. Suramin promotes proliferation and scattering of renal epithelial cells. J. Pharmacol. Exp. Ther., 314: 383-390.
    CrossRef  |  PubMed  |  Direct Link  |  

  62. Zhuang, S., Y. Dang and R.G. Schnellmann, 2004. Requirement of the epidermal growth factor receptor in renal epithelial cell proliferation and migration. Am. J. Physiol. Renal Physiol., 287: F365-F372.
    CrossRef  |  PubMed  |  Direct Link  |  

  63. Zhuang, S. and R.G. Schnellmann, 2004. H2O2-induced transactivation of EGF receptor requires Src and mediates ERK1/2, but not Akt, activation in renal cells. Am. J. Physiol. Renal Physiol., 286: F858-F865.
    PubMed  |  Direct Link  |  

  64. Zhuang, S., G.D. Ouedraogo and I.E. Kochevar, 2003. Downregulation of epidermal growth factor receptor signaling by singlet oxygen through activation of caspase-3 and protein phosphatases. Oncogene, 22: 4413-4424.
    CrossRef  |  PubMed  |  Direct Link  |  

  65. Zhuang, S. and I.E. Kochevar, 2003. Ultraviolet a radiation induces rapid apoptosis of human leukemia cells by fas ligand-independent activation of the fas death pathway. Photochem. Photobiol., 78: 61-67.
    CrossRef  |  PubMed  |  Direct Link  |  

  66. Zhuang, S. and I.E. Kochevar, 2003. Singlet oxygen-induced activation of Akt/protein kinase B is independent of growth factor receptors. Photochem. Photobiol., 78: 361-371.
    CrossRef  |  PubMed  |  Direct Link  |  

  67. Zhuang, S., J.T. Demirs and I.E. Kochevar, 2001. Protein kinase C inhibits singlet oxygen-induced apoptosis by decreasing caspase-8 activation. Oncogene, 20: 6764-6776.
    PubMed  |  Direct Link  |  

  68. Zhuang, S., S.I. Hirai and S. Ohno, 2000. Hyperosmolality induces activation of cPKC and nPKC, a requirement for ERK1/2 activation in NIH/3T3 cells. Am. J. Physiol. Cell Physiol., 278: C102-C109.
    PubMed  |  Direct Link  |  

  69. Zhuang, S., J.T. Demirs and I.E. Kochevar, 2000. p38 mitogen-activated protein kinase mediates bid cleavage, mitochondrial dysfunction and caspase-3 activation during apoptosis induced by singlet oxygen but not by hydrogen peroxide. J. Biol. Chem., 275: 25939-25948.
    CrossRef  |  

  70. Zhuang, S. and G. Simon, 2000. Peroxynitrite-induced apoptosis involves activation of multiple caspases in HL-60 cells. Am. J. Physiol. Cell Physiol., 279: C341-C351.
    PubMed  |  Direct Link  |  

  71. Kochevar, I.E., M.C. Lynch, S. Zhuang and C.R. Lambert, 2000. Singlet oxygen, but not oxidizing radicals, induces apoptosis in HL-60 cells. Photochem. Photobiol., 72: 548-553.
    CrossRef  |  PubMed  |  Direct Link  |  

  72. Hao, J., S. Zhuang and Z. Wang, 2000. Effect of calcium bicarbonate on callium and phosphate in patients on hemodialysis. Youji Med. J., 23: 16-18.

  73. Zhuang, S., M.C. Lynch and I.E. Kochevar, 1999. Caspase-8 mediates caspase-3 activation and cytochrome c release during singlet oxygen-induced apoptosis of HL-60 cells. Exp. Cell Res., 250: 203-212.
    CrossRef  |  PubMed  |  Direct Link  |  

  74. Zhuang, S., M.C. lynch and I.E. Kochevar, 1998. Activation of protein kinase C is required for protection of cells against apoptosis induced by singlet oxygen. FEBS Lett., 437: 158-162.
    CrossRef  |  PubMed  |  Direct Link  |  

  75. Zhuang, S., S.I. Hirai, K. Mizuno, A. Suzuki and K. Akimoto et al., 1997. Involvement of protein kinase C during activation of mitogen-activated protein kinase by UV irradiation. Biochem. Biophys. Res. Commun., 240: 273-278.

  76. Marumo, F. and S. Zhuang, 1995. Nephrotic syndrome. Drugs, 126: 33-36.

  77. Zhuang, S., Z. Wang, J. Hao, H. Zhao and X. Fang, 1993. Sources of endotoxemia in patients with hemodialysis. Beij. Biomed. Eng., 12: 117-119.

  78. Zhuang, S., W. Li and Z. Wang, 1993. Effect of large doses of vitamin E on anemia in patients undergoing maintenance hemodialysis. Beij. Biomed. Eng., 12: 36-38.

  79. Zhuang, S., L. Ma and Z. Wang, 1993. Cerebral hemorrage in patients on maintenance hemodialysis (with analysis of 8 cases). Beij. Biomed. Eng., 12: 39-40.

  80. Zhuang, S., Z. Li and H. Yan, 1992. The change of plasma atrial natriuretic factor levels in chronic renal failure during hemodialysis. Beij. Biomed. Eng., 11: 93-96.

  81. Zhuang, S., L. Hao and Z. Wang, 1992. Plasma concentration of ascorbic acid in patients undergoing maintenance hemodialysis. Beij. Biomed. Eng., 11: 44-45.

  82. Zhuang, S., 1992. Peritoneal Dialysis, Hemoperfusion and Arteriovenous Fistula. In: Blood Purification, Wang, Z. (Ed.) 1st Edn., Beijing Sciences and Technology Publishing House, Beijing, China.

  83. Zhuang, S. and Z. Wang, 1992. First-use syndrome (a case report and literature review). Beij. Biomed. Eng., 11: 97-98.

  84. Zhuang, S. and Z. Wang, 1992. Alternation of serum vitamin A levels in patients undergoing chronic hemodialysis. Beij. Biomed. Eng., 11: 173-174.

  85. Wang, Z., Q. Ma, J. Hao and S. Zhuang, 1992. Evaluation of adequate hemodialysis by means of urea kinetic modeling. Chin. J. Org. Trans., 13: 212-216.

  86. Zhuang, S., 1991. Dialysis Related Hematologic Disorders. In: Handbook of Dialysis, Wang, Z. (Ed.) 1st Edn., Beijing Sciences and Technology Publishing House, Beijing, China.

  87. Wang, Z., S. Zhuang, X. Yuang, Q. Ma, Y. Gao and L. Bai, 1991. The dynamic change of plasma calcium fractions during hemodialysis. J. Chin. Urol., 12: 358-360.

  88. Ma, L., S. Zhuang and Z. Wang, 1991. Acquired cystic disease of the kidney in patients undergoing maintenance hemodialysis. Chin. J. Dial. Eng., 2: 19-22.