Dr. Xin-Min  Li

Dr. Xin-Min Li

Professor
University of Alberta, Canada


Highest Degree
Ph.D. in Physiology from Norman Bethune University of Medical Sciences, Changchun, China

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Area of Interest:

Pharmacology and Toxicology
100%
Physiology
62%
Neurodegeneration
90%
Psychiatric Disorders
75%
Neuropharmacology
55%

Selected Publications

  1. Zhu, S., J. He, R. Zhang, L. Kong, A. Tempier, J. Kong and X.M. Li, 2013. Therapeutic effects of quetiapine on memory deficit and brain β-amyloid plaque pathology in a transgenic mouse model of Alzheimer's disease. Curr. Alzheimer Res., 10: 270-278.
    Direct Link  |  

  2. Tempier, A., J. He, S. Zhu, R. Zhang and L. Kong et al., 2013. Quetiapine modulates conditioned anxiety and alternation behavior in Alzheimer's transgenic mice. Curr. Alzheimer Res., 10: 199-206.
    Direct Link  |  

  3. Chen, X., T. Guan, X. Zhang, C. Li and H. Shang et al., 2013. S-nitrosylated protein disulfide isomerase contributes to mutant SOD1 aggregates in amyotrophic lateral sclerosis. J. Neurochem., 124: 45-58.
    CrossRef  |  

  4. Zhang, Y., H. Zhang, L. Wang, W. Jiang and H. Xu et al., 2012. Quetiapine enhances oligodendrocyte regeneration and myelin repair after cuprizone-induced demyelination. Schizphr. Res., 138: 8-17.
    CrossRef  |  

  5. Zhang, R., S. Zhu, H. Zhang, H. Wang and A. Adilijiang et al., 2012. Myelination deficit in a phencyclidine-induced neurodevelopmental model of schizophrenia. Brain Res., 1469: 136-143.
    CrossRef  |  

  6. Wang, H., J. He, R. Zhang, S. Zhu and J. Wang et al., 2012. Sensorimotor gating and memory deficits in an APP/PS1 double transgenic mouse model of Alzheimer's disease. Behav. Brain Res., 233: 237-243.
    CrossRef  |  

  7. Shi, R., J. Weng, L. Zhao, X.M. Li, T.M. Gao and J. Kong, 2012. Excessive autophagy contributes to neuron death in cerebral ischemia. CNS Neurosci. Ther., 18: 250-260.
    CrossRef  |  

  8. Mei, F., S. Guo, Y. He, L. Wang and H. Wang et al., 2012. Quetiapine, an atypical antipsychotic, is protective against autoimmune-mediated demyelination by inhibiting effector t cell proliferation. PLoS One, Vol. 7. 10.1371/journal.pone.0042746.
    CrossRef  |  Direct Link  |  

  9. Chen, X., T. Guan, C. Li, H. Shang, L. Cui, X.M. Li and J. Kong, 2012. SOD1 aggregation in astrocytes following ischemia/reperfusion injury: A role of NO-mediated S-nitrosylation of Protein Disulfide Isomerase (PDI). J. Neuroinflammation, Vol. 9. 10.1186/1742-2094-9-237.
    CrossRef  |  

  10. Chen, X., H. Shang, X. Qiu, N. Fujiwara and L. Cui et al., 2012. Oxidative modification of cysteine 111 promotes disulfide bond-independent aggregation of SOD1. Neurochem. Res., 37: 835-845.
    CrossRef  |  

  11. Bi, X., Y. Zhang, B. Yan, S. Fang and J. He et al., 2012. Quetiapine prevents oligodendrocyte and myelin loss and promotes maturation of oligodendrocyte progenitors in the hippocampus of global cerebral ischemia mice. J. Neurochem., 123: 14-20.
    CrossRef  |  

  12. Zhang, Z., R. Shi, J. Weng, X. Xu, X.M. Li, T.M. Gao and J. Kong, 2011. The proapoptotic member of the Bcl-2 family Bcl-2 / E1B-19K-interacting protein 3 is a mediator of caspase-independent neuronal death in excitotoxicity. FEBS J., 278: 134-142.
    CrossRef  |  

  13. Wang, Y., Y. Zhang, J. He, H. Zhang and X. Lan et al., 2011. Hyperforin promotes mitochondrial function and development of oligodendrocytes. J. Neurochem., 119: 555-568.
    CrossRef  |  

  14. Tian, L., C. Meng, H. Yan, Q. Zhao and Q. Liu et al., 2011. Convergent evidence from multimodal imaging reveals amygdala abnormalities in schizophrenic patients and their first-degree relatives. PLoS One, Vol. 6. 10.1371/journal.pone.0028794.
    CrossRef  |  

  15. Xu, H., H.J. Yang, B. McConomy, R. Browning and X.M. Li, 2010. Behavioral and neurobiological changes in C57BL/6 mouse exposed to cuprizone: Effects of antipsychotics. Front. Behav. Neurosci., Vol. 4. 10.3389/fnbeh.2010.00008.
    CrossRef  |  

  16. Wang, H., H. Xu, J. Niu, F. Mei and X.M. Li et al., 2010. Haloperidol activates quiescent oligodendroglia precursor cells in the adult mouse brain. Schizophr. Res., 119: 164-174.
    CrossRef  |  

  17. Niu, J., F. Mei, N. Li, H. Wang, X. Li, J. Kong and L. Xiao, 2010. Haloperidol promotes proliferation but inhibits differentiation in rat oligodendrocyte progenitor cell cultures. Biochem. Cell Biol., 88: 611-620.
    CrossRef  |  

  18. Fang, S., B. Yan, D. Wang, X. Bi and Y. Zhang et al., 2010. Chronic effects of venlafaxine on synaptophysin and neuronal cell adhesion molecule in the hippocampus of cerebral ischemic mice. Biochem. Cell. Biol., 88: 655-663.
    CrossRef  |  

  19. Yu, Y., J. He, Y. Zhang, H. Luo and S. Zhu et al., 2009. Increased hippocampal neurogenesis in the progressive stage of Alzheimer's disease phenotype in an APP/PS1 double transgenic mouse model. Hippocampus, 19: 1247-1253.
    CrossRef  |  Direct Link  |  

  20. Yang, H.J., H. Wang, Y. Zhang, L. Xiao and R. Clough et al., 2009. Region-specific susceptibilities to cuprizone-induced lesions in the mouse forebrain: Implications for the pathophysiology of schizophrenia. Brain Res., 1270: 121-130.
    CrossRef  |  

  21. Xu, H., H.J. Yang, Y. Zhang, R. Clough, R. Browning and X.M. Li, 2009. Behavioral and neurobiological changes in C57BL/6 mice exposed to cuprizone. Behav. Neurosci., 123: 418-429.
    CrossRef  |  

  22. He, J., J. Kong, Q.R. Tan and X.M. Li, 2009. Neuroprotective effect of atypical antipsychotics in cognitive and non-cognitive behavioral impairment in animal models. Cell Adh. Migr., 3: 129-137.
    Direct Link  |  

  23. He, J., H. Luo, B. Yan, Y. Yu and H. Wang et al., 2009. Beneficial effects of quetiapine in a transgenic mouse model of Alzheimer's disease. Neurobiol. Aging, 30: 1205-1216.
    CrossRef  |  

  24. Cao, X., X.M. Li and D.D. Mousseau, 2009. Calcium alters monoamine oxidase-a parameters in human cerebellar and rat glial C6 cell extracts: Possible influence by distinct signalling pathways. Life Sci., 85: 262-268.
    CrossRef  |  

  25. Cao, X., L.W. Rui, P.R. Pennington, J. Chlan-Fourney and Z.J. Jiang et al., 2009. Serine 209 resides within a putative p38(MAPK) consensus motif and regulates monoamine oxidase-a activity. J. Neurochem., 111: 101-110.
    CrossRef  |  

  26. Bi, S., B. Yan, S. Fang, Y. Yang, J. He, X.M. Li and J. Kong, 2009. Quetiapine regulates neurogenesis in ischemic mice by inhibiting NF-κB p65/p50 expression. Neurol. Res., 31: 159-166.
    CrossRef  |  Direct Link  |  

  27. Zhang, Y., H. Xu, W. Jiang, L. Xiao and B. Yan et al., 2008. Quetiapine alleviates the cuprizone-induced white matter pathology in the brain of C57BL/6 mouse. Schizophrenia Res., 106: 182-191.
    CrossRef  |  

  28. Xu, H., H. Wang, L. Zhuang, B. Yan and Y. Yu et al., 2008. Demonstration of an anti-oxidative stress mechanism of quetiapine: Implications for the treatment of Alzheimer's disease. FEBS J., 275: 3718-3728.
    CrossRef  |  Direct Link  |  

  29. Xiao, L., H. Xu, Y. Zhang, Z. Wei and J. He et al., 2008. Quetiapine facilitates oligodendrocyte development and prevents mice from myelin breakdown and behavioral changes. Mol. Psychiatry, 13: 697-708.
    CrossRef  |  PubMed  |  Direct Link  |  

  30. Lieberman, J.A., F.P. Bymaster, H.Y. Meltzer, A.Y. Deutch and G.E. Duncan et al., 2008. Antipsychotic drugs: Comparison in animal models of efficacy, neurotransmitter regulation and neuroprotection. Pharmacol. Rev., 60: 358-403.
    CrossRef  |  Direct Link  |  

  31. Zhang, Y., H. Xu, J. He, B. Yan, W. Jiang and X.M. Li, 2007. Quetiapine reverses altered locomotor activity and tyrosine hydroxylase immunoreactivity in rat caudate putamen following long-term haloperidol treatment. Neurosci. Lett., 420: 66-71.
    CrossRef  |  

  32. Yan, B., X. Bi, J. He, Y. Zhang and S. Thakur et al., 2007. Quetiapine attenuates spatial memory impairment and hippocampal neurodegeneration induced by bilateral common carotid artery occulusion in mice. Life Sci., 81: 353-361.
    CrossRef  |  

  33. Yan, B., J. He, H. Xu, Y. Zhang and X. Bi et al., 2007. Quetiapine attenuates the depressive and anxiolytic-like behavioural changes induced by global cerebral ischemia in mice. Behav. Brain Res., 182: 36-41.
    CrossRef  |  

  34. Li, X.M. and H. Xu, 2007. In vitro and in vivo evidence for neuroprotective effects of antipsychotic drugs: Implications for the pathophysiology and treatment of schizophrenia. Int. Rev. Neurobiol., 77: 107-142.
    Direct Link  |  

  35. Cao, X., Z. Wei, G.G. Gabriel, X.M. Li and D.D. Mousseau, 2007. Calcium-sensitive regulation of monoamine oxidase-a contributes to the production of peroxyradicals in hippocampal cultures: Implications for Alzheimer disease-related pathology. BMC Neurosci., Vol. 8. 10.1186/1471-2202-8-73.
    CrossRef  |  

  36. Xu, H., Z. Chen, J. He, S. Haimanot and X.M. Li, 2006. Synergetic effects of quetiapine and venlafaxine in preventing the chronic restraint stress-induced decrease in cell proliferation and BDNF expression in rat hippocampus. Hippocampus, 16: 551-559.
    CrossRef  |  

  37. Wei, Z., D.D. Mousseau, Y. Dai, X. Cao and X.M. Li, 2006. Haloperidol induces apoptosis via the sigma2 receptor system and Bcl-XS. J. Pharmacogenomics, 6: 279-288.
    Direct Link  |  

  38. Shao, Z., H. Wang, L.E. Dyck and X.M. Li, 2006. Antipsychotic drugs cause glial cell line-derived neurotrophic factor secretion from C6 glioma cells. J. Psychiatry Neurosci., 31: 32-37.
    Direct Link  |  

  39. He, J., Y. Yang, Y. Yu, X. Li and X.M. Li, 2006. The effects of chronic administration of quetiapine on the methamphetamine-induced recognition memory impairment and dopaminergic terminal deficit in rats. Behav. Brain Res., 172: 39-45.
    Direct Link  |  

  40. He, J., H. Xu, Y. Yang, D. Rajakumar, X. Li and X.M. Li, 2006. The effects of chronic administration of quetiapine on the phencyclidine-induced reference memory impairment and decrease of Bcl-XL/Bax ratio in the posterior cingulate cortex in rats. Behav. Brain Res., 168: 236-242.
    CrossRef  |  

  41. Bai, O., H. Xu and X.M. Li, 2006. Haloperidol and atypical antipsychotics share a same action of decreasing p75NTR mRNA levels in PC12 cells. Life Sci., 79: 570-574.
    CrossRef  |  

  42. Wang, H., H. Xu, L. Dyck and X.M. Li, 2005. Olanzapine and quetiapine protect PC12 cells from beta-amyloid peptide (25-35)-induced oxidative stress and the ensuing apoptosis. J. Neurosci. Res., 81: 572-580.
    CrossRef  |  PubMed  |  

  43. Luo, C., H. Xu and X.M. Li, 2005. Quetiapine reverses the suppression of hippocampal neurogenesis caused by repeated restraint stress. Brain Res., 1063: 32-39.
    CrossRef  |  

  44. Kolla, N., Z. Wei, J.S. Richardson and X.M. Li, 2005. Amitriptyline and fluoxetine protect PC12 cells from cell death induced by hydrogen peroxide. J. Psychiatry Neurosci., 30: 196-201.
    PubMed  |  

  45. He, J., Y. Yang, H. Xu, X. Zhang and X.M. Li, 2005. Olanzapine attenuates the okadaic acid-induced spatial memory impairment and hippocampal cell death in rats. Neuropsychopharmacology, 30: 1511-1520.
    PubMed  |  

  46. He, J., H. Xu, Y. Yang, X. Zhang and X.M. Li, 2005. Chronic administration of quetiapine alleviates the anxiety-like behavioural changes induced by neurotoxic regimen of dl-amphetamine in rats. Behav. Brain Res., 160: 178-187.
    CrossRef  |  PubMed  |  

  47. Chen, Z., H. Xu, S. Haimanot, X. Li and X.M. Li, 2005. Quetiapine and venlafaxine synergically regulate heme oxygenase-2 protein expression in hippocampal formations of stressed rats. Neurosci. Lett., 389: 173-177.

  48. Xu, H., J.S. Richardson, C. Luo and X.M. Li, 2004. Recovery of hippocampal cell proliferation and BDNF levels, both of which are reduced by repeated restraint stress, is accelerated by chronic venlafaxine. Pharmacogenomics J., 4: 322-331.
    CrossRef  |  

  49. Xu, H., J. He, J.S. Richardson and X.M. Li, 2004. The response of synaptophysin and microtubule-associated protein 1 to restraint stress in rat hippocampus and its modulation by venlafaxine. J. Neurochem., 91: 1380-1388.
    CrossRef  |  

  50. Luo, C., H. Xu and X.M. Li, 2004. Post-stress changes in BDNF and Bcl-2 immuno-reactivities in hippocampal neurons: Effect of chronic administration of olanzapine. Brain Res., 1025: 194-202.
    CrossRef  |  

  51. He, J., H. Xu, Y. Yang, X. Zhang and X.M. Li, 2004. Neuroprotective effects of olanzapine on methamphetamine-induced neurotoxicity are associated with an inhibition of hyperthermia and prevention of Bcl-2 decrease in rats. Brain Res., 1018: 186-192.
    CrossRef  |  

  52. Bai, O., H. Zhang and X.M. Li, 2004. Antipsychotic drugs clozapine and olanzapine upregulate Bcl-2 mRNA and protein in rat frontal cortex and hippocampus. Brain Res., 1010: 81-86.
    CrossRef  |  PubMed  |  

  53. Xu, H., J.S. Richardson and X.M. Li, 2003. Dose-related effects of chronic antidepressants on neuroprotective proteins BDNF, Bcl-2 and Cu/Zn-SOD in rat hippocampus. Neuropsychopharmacol., 28: 53-62.
    PubMed  |  

  54. Wei, Z., O. Bai, J.S. Richardson, D.D. Mousseau and X.M. Li, 2003. Olanzapine protects PC12 cells from oxidative stress induced by hydrogen peroxide. J. Neurosci. Res., 73: 364-368.
    CrossRef  |  PubMed  |  

  55. Wei, Z., D.D. Mousseau, J.S. Richardson, L.E. Dyck and X.M. Li, 2003. Atypical antipsychotics attenuate neurotoxicity of β-amyloid(25-35) by modulating Bax and Bcl-Xl/s expression and localization. J. Neurosci. Res., 74: 942-947.
    CrossRef  |  PubMed  |  

  56. Qing, H., H. Xu, Z. Wei, K. Gibson and X.M. Li, 2003. The ability of atypical antipsychotic drugs vs. haloperidol to protect PC12 cells against MPP+-induced apoptosis. Eur. J. Neurosci., 17: 1563-1570.
    CrossRef  |  

  57. Cui, S.S., C.P. Yang, R.C. Bowen, O. Bai, X.M. Li, W. Jiang and W. Zhang, 2003. Valproic acid enhances axonal regeneration and recovery of motor function after sciatic nerve axotomy in adult rats. Brain Res., 975: 229-236.
    CrossRef  |  PubMed  |  

  58. Bai, O., J. Chlan-Fourney, R. Bowen, D. Keegan and X.M. Li, 2003. Expression of brain-derived neurotrophic factor mRNA in rat hippocampus after treatment with antipsychotic drugs. J. Neurosci. Res., 71: 127-131.
    CrossRef  |  PubMed  |  

  59. Xu, H., H. Qing, W. Lu, D. Keegana, J. Richardson, J. Chlan-Fourney and X.M. Li, 2002. Quetiapine attenuates the immobilization stress-induced decrease of brain-derived neurotrophic factor expression in rat hippocampus. Neurosci. Lett., 321: 65-68.
    CrossRef  |  PubMed  |  

  60. Chlan-Fourney, J., P.C. Ashe, K. Nylen, A.V. Juorio and X.M. Li, 2002. Differential regulation of hippocampal BDNF mRNA by typical and atypical antipsychotic administration. Brain Res., 954: 11-20.
    CrossRef  |  PubMed  |  

  61. Bai, O., Z. Wei, W. Lu, R. Bowen, D. Keegan and X.M. Li, 2002. Protective effects of atypical antipsychotic drugs on PC12 cells after serum withdrawal. J. Neurosci. Res., 69: 278-283.
    CrossRef  |  PubMed  |  

  62. Ashe, P.C., J. Chlan-Fourney, A.V. Juorio and X.M. Li, 2002. Brain-derived neurotrophic factor (BDNF) mRNA in rats with neonatal ibotenic acid lesions of the ventral hippocampus. Brain Res., 956: 126-135.
    CrossRef  |  PubMed  |  

  63. Mohapel, P., X. Zhang, G. Gillespie, J. Chlan-Fourney and D.K. Hannesson et al., 2001. Kindling of claustrum and insular cortex: Comparison to pherirhinal cortex. Eur. J. Neurosci., 13: 1501-1519.
    PubMed  |  

  64. Fang, J., G. McKay, A. Remillard, X.M. Li and K.K. Midha, 2001. In vitro characterization of the metabolism of haloperidol using recombinant cytochrome P450 enzymes and human liver microsomes. Drug Metabol. Dispos., 12: 1-6.
    PubMed  |