Dr. Tao  Chen

Dr. Tao Chen

Professor
US Food and Drug Administration, USA


Highest Degree
Ph.D. in Toxicology from University of Arkansas, USA

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Area of Interest:

Pharmacology and Toxicology
100%
Mutagenesis
62%
Applied Toxicology
90%
Carcinogenesis
75%
Ecotoxicology
55%

Selected Publications

  1. Meng, F., Z. Li, J. Yan, M. Manjanatha, S. Shelton and T. Chen, 2013. Tissue-specific response of microRNAs to carcinogenicity and mutagenicity of aristolochic acid in rats. Toxicol. Sci. (In Press). .

  2. Meng, F., Y. Luan, J. Yan and T. Chen, 2013. Regulatory Role of MicroRNAs in Mutagenesis. John Wiley & Sons, Ltd., USA.

  3. Meng, F., J. Yan, Y. Li, P.P. Fu and L.H. Fossom et al., 2013. Genotoxicity of 2-bromo-3'-chloropropiophenone. Toxicol. Appl. Pharmacol., 270: 158-163.
    PubMed  |  

  4. Luan, Y., M. Liu, X. Qi, M. Wu, L. Xu, J. Ren and T. Chen, 2013. Absence of mature microRNAs inactivates the response of gene expression to carcinogenesis induced by N-ethyl-N-nitrosourea in mouse liver. Int. J. Mol. Sci. (In Press). .

  5. Li, Y., J.A. Bhalli, J. Yan, M.J. Pearce and R. Sadiq et al., 2013. Genotoxicity assessment of silver nanoparticles using mouse micronucleus and Pig-a assays. Nanotoxicology (In Press). .

  6. Chen, X., Y. Zhang, J. Yan, R. Sadiq and T. Chen, 2013. Mutation suppression by miR-34a is P53-dependent in human lymphoblastoid TK6 cells. Mutat. Res., 758: 35-40.
    CrossRef  |  PubMed  |  

  7. Woodruff, R.S., Y. Li, J. Yan, M. Bishop and M.Y. Jones et al., 2012. Genotoxicity evaluation of titanium dioxide nanoparticles using the Ames test and Comet assay. J. Appl. Toxicol., 32: 934-943.
    PubMed  |  

  8. Sadiq, R., J.A. Bhalli, , J. Yan, R.S. Woodruff and M.G. Pearce et al., 2012. Genotoxicity of TiO2 anatase nanoparticles in B6C3F1 male mice evaluated using Pig-a and flow cytometric micronucleus assays. Mutat. Res., 745: 65-72.
    PubMed  |  

  9. Meng, F., M. Hackenber, Z. Li, J. Yan and T. Chen, 2012. Discovery of novel microRNAs in rat kidney using next generation sequencing and microarray validation. PLoS One, Vol. 7. .
    Direct Link  |  

  10. Mei, N., Y. Zhang, Y. Chen, X. Guo and W. Ding et al., 2012. Silver nanoparticle-induced mutations and oxidative stress in mouse lymphoma cells. Environ. Mol. Mutagen, 53: 409-419.
    PubMed  |  

  11. McDaniel, L.P., E.R. Elander, X. Guo, T. Chen, V.M. Arlt and N. Mei, 2012. Mutagenicity and DNA adduct formation by aristolochic acid in the spleen of Big Blue(R) rats. Environ. Mol. Mutagen., 53: 358-368.
    PubMed  |  

  12. Li, Y., D.H. Chen, J. Yan, Y. Chen, R.A. Mittelstaedt and Y. Zhang et al., 2012. Genotoxicity of silver nanoparticles evaluated using the Ames test and in vitro micronucleus assay. Mutat. Res., 745: 4-10.
    PubMed  |  

  13. Chen, X., J. Yan and T. Chen, 2012. Expression level of miR-34a rather than P53 gene status correlates with mutability in related human lymphoblast cell lines. Mol. Carcinog, 51: 674-677.
    PubMed  |  

  14. Chen, T., Z. Li, J. Yan, X. Yang and W. Salminen, 2012. MicroRNA expression profiles distinguish the carcinogenic effects of riddelliine in rat liver. Mutagenesis, 27: 59-66.
    PubMed  |  

  15. Zhang, Y., Y. Xu, Z. Li, T. Chen and S.M. Lantz et al., 2011. Mechanistic toxicity evaluation of uncoated and PEGylated single-walled carbon nanotubes in neuronal PC12 cells. ACS Nano, 5: 7020-7033.
    PubMed  |  

  16. Wang, Y., F. Meng, V.M. Arlt, N. Mei, T. Chen and B.L. Parsons, 2011. Aristolochic acid-induced carcinogenesis examined by ACB-PCR quantification of H-Ras and K-Ras mutant fraction. Mutagenesis, 26: 619-628.
    PubMed  |  

  17. Su, Z., Z. Li, T. Chen, Q.Z. Li and H. Fang et al., 2011. Comparing next-generation sequencing and microarray technologies in a toxicological study of the effects of aristolochic acid on rat kidneys. Chem. Res. Toxicol., 24: 1486-1493.
    PubMed  |  

  18. Mahmood, M., Z. Li, D. Casciano, M.V. Khodakovskaya and T. Chen et al., 2011. Nanostructural materials increase mineralization in bone cells and affect gene expression through miRNA regulation. J. Cell Mol. Med., 15: 2297-2306.
    PubMed  |  

  19. Li, Z., J.C. Fuscoe and T. Chen, 2011. MicroRNAs and their predicted target messenger RNAs are deregulated by exposure to a carcinogenic dose of comfrey in rat liver. Environ. Mol. Mutagen, 52: 469-478.
    PubMed  |  

  20. Ross, J.A., C.F. Blackman, S.F. Thai, Z. Li, M. Kohan, C.P. Jones and T. Chen, 2010. A potential microRNA signature for tumorigenic conazoles in mouse liver. Mol. Carcinog., 49: 320-323.
    PubMed  |  

  21. Mei, N., L. Guo, P.P. Fu, J.C. Fuscoe, Y. Luan and T. Chen, 2010. Metabolism, genotoxicity and carcinogenicity of comfrey. J. Toxicol. Environ. Health B Crit. Rev., 13: 509-526.
    PubMed  |  

  22. Mei, N., J. Hu, Q. Xia, P.P. Fu, M.M. Moore and T. Chen, 2010. Cytotoxicity and mutagenicity of retinol with ultraviolet A irradiation in mouse lymphoma cells. Toxicol. In Vitro, 24: 439-444.
    PubMed  |  

  23. Li, Z., W.S. Branham, S.L. Dial, Y. Wang, L. Guo, L. Shi and T. Chen, 2010. Genomic analysis of microRNA time-course expression in liver of mice treated with genotoxic carcinogen N-ethyl-N-nitrosourea. BMC Genomics, Vol. 11. .
    PubMed  |  

  24. Guo, L., N. Mei, Q. Xia, T. Chen, P.C. Chan and P.P. Fu, 2010. Gene expression profiling as an initial approach for mechanistic studies of toxicity and tumorigenicity of herbal plants and herbal dietary supplements. J. Environ. Sci. Health. C Environ. Carcinog. Ecotoxicol. Rev., 28: 60-87.
    PubMed  |  

  25. Chen, T., R.H. Heflich, M.M. Moore and N. Mei, 2010. Differential mutagenicity of aflatoxin B1 in the liver of neonatal and adult mice. Environ. Mol. Mutagen., 51: 156-163.
    PubMed  |  

  26. Chen, T., N. Mei and P.P. Fu, 2010. Genotoxicity of pyrrolizidine alkaloids. J. Appl. Toxicol., 30: 183-196.
    PubMed  |  

  27. Chen, T., 2010. The role of MicroRNA in chemical carcinogenesis. J. Environ. Sci. Health C Environ. Carcinog. Ecotoxicol. Rev., 28: 89-124.
    PubMed  |  

  28. Wang, J., J.R. Sawyer, L. Chen, T. Chen, M. Honma, N. Mei and M.M. Moore, 2009. The mouse lymphoma assay detects recombination, deletion and aneuploidy. Toxicol. Sci., 109: 96-105.
    CrossRef  |  

  29. Wang, J. and T. Chen, 2009. Sequencing analysis of mutations induced by N-ethyl-N-nitrosourea at different sampling times in mouse bone marrow. J. Applied Toxicol., 30: 133-141.
    PubMed  |  

  30. Mei, N., T. Chen, D.E. Godar and M.M. Moore, 2009. UVA-induced photomutagenicity of retinyl palmitate. Mutat. Res., 677: 105-106.
    PubMed  |  

  31. Li, Z.G., Z.Q. Su, Z.N. Wen, L.M. Shi and T. Chen, 2009. Microarray platform consistency is revealed by biologically functional analysis of gene expression profiles. BMC Bioinformatics, Vol. 10. 10.1186/1471-2105-10-S11-S12.
    CrossRef  |  Direct Link  |  

  32. Fu, P.P., H.M. Chiang, Q.S. Xia, T. Chen and B.H. Chen et al., 2009. Quality assurance and safety of herbal dietary supplements. J. Environ. Sci. Health, 27: 91-119.
    PubMed  |  

  33. Mei, N., J.X. Hu, M.I. Churchwell, L. Guo, M.M. Moore, D.R. Doerge and T. Chen, 2008. Genotoxic effects of acrylamide and glycidamide in mouse lymphoma cells. Food Chem. Toxicol., 46: 628-636.
    Direct Link  |  

  34. Chen, T., N. Mei and L. Guo, 2008. Determination of biomarker genes for the exposure of aristolochic acid in rat kidney. The Toxicol., 102: 76-77.

  35. Wang, J.Y., T. Chen, M. Honma, L. Chen and M.M. Moore, 2007. 3 '-azido-3 '-deoxythymidine induces deletions in L5178Y mouse lymphoma cells. Environ. Mol. Mutagen., 48: 248-257.

  36. Mei, X.B. and T. Chen, 2007. The mutant frequencies and types of mutations induced by comfrey in the lungs of transgenic big blue rats. J. Food Drug Anal., 15: 458-465.

  37. Mei, N., L. Guo, R. Liu, J.C. Fuscoe and T. Chen, 2007. Gene expression changes induced by the tumorigenic pyrrolizidine alkaloid riddelliine in liver of big blue rats. BMC Bioinform., Vol. 8. 10.1186/1471-2105-8-S7-S4.
    CrossRef  |  

  38. Guo, L., N. Mei, S. Dial, J. Fuscoe and T. Chen, 2007. Comparison of gene expression profiles altered by comfrey and riddelliine in rat liver. BMC Bioinformatics, Vol. 8. .
    Direct Link  |  

  39. Fu, P.P., Q.S. Xia, J.J. Yin, S.H. Cherng and J. Yan et al., 2007. Photodecomposition of vitamin A and photobiological implications for the skin. Photochem. Photobiol., 83: 409-424.
    PubMed  |  

  40. Chen, T., R.A. Mittelstaedt, A. Aidoo, L.P. Hamilton, F.A. Beland, D.A. Casciano and R.H. Heflich, 2007. Comparison of Hprt and lacl mutant frequency with DNA adduct formation in N-hydroxy-2-acetylaminoflourene-treated Big Blue rats. Environ. Mol. Mutagen., 37: 195-202.

  41. Chen, T., 2007. Genotoxicity of aristolochic acid: A review. J. Food Drug Anal., 15: 387-399.

  42. Chen, J.J., T. Lee, R.R. Delongchamp, T. Chen and C.A. Tsai, 2007. Significance analysis of groups of genes in expression profiling studies. Bioinformatics, 23: 2104-2112.
    Direct Link  |  

  43. Aidoo, A., T. Chen, M.E. Bishop, S. Shelton, L.E. Lyn-Cook and M.G. Manjanatha, 2007. Studies on the influence of dietary isoflavones, daidzein and genistein, in chemical mutagenesis and tumor development in female rates. Regulatory Res. Perspect., 7: 1-21.

  44. Sun, H., H. Fang, T. Chen, R. Perkins and W. Tong, 2006. GOFFA: Gene ontology for functional analysis-a FDA gene ontology tool for analysis of genomic and proteomic data. BMC Bioinform., Vol. 7. 10.1186/1471-2105-7-S2-S23.
    CrossRef  |  PubMed  |  Direct Link  |  

  45. Moore, M.M. and T. Chen, 2006. Mutagenicity of bromate: Implications for cancer risk assessment. Toxicology, 221: 190-196.
    CrossRef  |  PubMed  |  Direct Link  |  

  46. Mei, N., V.M. Arlt, D.H. Phillips, R.H. Heflich and T. Chen, 2006. DNA adduct formation and mutation induction by aristolochic acid in rat kidney and liver. Mutat. Res. Fund. Mol. Mech. Mutagenesis, 602: 83-91.
    CrossRef  |  PubMed  |  Direct Link  |  

  47. Mei, N., Q.S. Xia, L. Chen, M.M. Moore, T. Chen and P.P. Fu, 2006. Photomutagenicity of anhydroretinol and 5,6-epoxyretinyl palmitate in mouse lymphoma cells. Chem. Res. Toxicol., 19: 1435-1440.
    CrossRef  |  PubMed  |  Direct Link  |  

  48. Mei, N., L. Guo, L. Zhang, L.M. Shi and Y.M.A. Sun et al., 2006. Analysis of gene expression changes in relation to toxicity and tumorigenesis in the livers of Big Blue transgenic rats fed comfrey (Symphytum officinale). BMC Bioinform., Vol. 7. 10.1186/1471-2105-7-S2-S16.
    CrossRef  |  PubMed  |  Direct Link  |  

  49. McKinzie, P.B., R.R. Delongchamp, T. Chen and B.L. Parsons, 2006. ACB-PCR measurement of K-ras codon 12 mutant fractions in livers of Big Blue rats treated with N-hydroxy-2-acetylaminofluorene. Mutagenesis, 21:: 391-397.
    CrossRef  |  PubMed  |  Direct Link  |  

  50. Han, T., J.Y. Wang, W.D. Tong, M.M. Moore, J.C. Fuscoe and T. Chen, 2006. Microarray analysis distinguishes differential gene expression patterns from large and small colony Thymidine kinase mutants of L5178Y mouse lymphoma cells. BMC Bioinform., Vol. 7. .
    PubMed  |  

  51. Guo, L., E.K. Lobenhofer, C. Wang, R. Shippy and S.C. Harris et al., 2006. Rat toxicogenomic study reveals analytical consistency across microarray platforms. Nat. Biotechnol., 24: 1162-1169.
    CrossRef  |  Direct Link  |  

  52. Chen, T., N. Mei and R.H. Heflich, 2006. Progress in Transgenic Rodent Mutation Assays. In: Progress in Mutation Research, Valon, C.L. (Ed.). Nova Science Publishers, Hauppauge, New York, pp: 71-96.

  53. Chen, T., L. Guo, L. Zhang, L. Shi and H. Fang et al., 2006. Gene expression profiles distinguish the carcinogenic effects of aristolochic acid in target (kidney) and non-target (liver) tissues in rats. BMC Bioinform., Vol. 7. .
    PubMed  |  

  54. Chen, L., N. Mei, L. Yao and T. Chen, 2006. Mutations induced by carcinogenic doses of aristolochic acid in kidney of Big Blue transgenic rats. Toxicol. Lett., 165: 250-256.
    CrossRef  |  PubMed  |  Direct Link  |  

  55. Singh, S.P., T. Chen, L. Chen, N. Mei and E. McLain et al., 2005. Mutagenic effects of 4-hydroxynonenal triacetate, a chemically protected form of the lipid peroxidation product 4-hydroxynonenal, as assayed in L5178Y/Tk+/- mouse lymphoma cells. J. Pharmacol. Exp. Ther., 313: 855-861.
    CrossRef  |  PubMed  |  Direct Link  |  

  56. Mei, N., R.H. Heflich, M.M. Moore and T. Chen, 2005. Age-dependent sensitivity of Big Blue transgenic mice to the mutagenicity of N-ethyl-N-nitrosourea (ENU) in liver. Mutat. Res. Fund. Mol. Mech. Mutagenesis, 572: 14-26.
    CrossRef  |  PubMed  |  Direct Link  |  

  57. Mei, N., Q.S. Xia, L. Chen, M.M. Moore, P.P. Fu and T. Chen, 2005. Photomutagenicity of retinyl palmitate by ultraviolet A irradiation in mouse lymphoma cells. Toxicol. Sci., 88: 142-149.
    CrossRef  |  PubMed  |  Direct Link  |  

  58. Mei, N., L. Guo, P.P. Fu, R.H. Heflich and T. Chen, 2005. Mutagenicity of comfrey (Symphytum officinale) in rat liver. Br. J. Cancer, 92: 873-875.
    CrossRef  |  PubMed  |  Direct Link  |  

  59. Chen, T., R.C. Hutts, N. Mei, X.L. Liu and M.E. Bishop et al., 2005. Endogenous estrogen status, but not genistein supplementation, modulates 7,12-dimethylbenz[a]anthracene -induced mutation in the liver c/l gene of transgenic big blue rats. Environ. Mol. Mutagen., 45: 409-418.
    Direct Link  |  

  60. Chen, T., R.A. Mittelstaedt, F.A. Beland, R.H. Heflich, M.M. Moore and B.L. Parsons, 2005. 4-aminobiphenyl induces liver DNA adducts in both neonatal and adult mice but induces liver mutations only in neonatal mice. Int. J. Cancer, 117: 182-187.
    CrossRef  |  PubMed  |  Direct Link  |  

  61. Aidoo, A., M.E. Bishop, S.D. Shelton, L.E. Lyn-Cook, T. Chen and M.G. Manjanatha, 2005. Effects of daidzein, genistein and 17 β-estradiol on 7,12-dimethylbenz[α]anthracene-induced mutagenicity and uterine dysplasia in ovariectomized rats. Nutr. Cancer, 53: 82-90.

  62. Wang, J.Y., X.L. Liu, R.H. Heflich and T. Chen, 2004. Time course of cII gene mutant manifestation in the liver, spleen and bone marrow of N-ethyl-N-nitrosourea-treated big blue transgenic mice. Toxicol. Sci., 82: 124-128.
    PubMed  |  

  63. Slikker, W., N. Mei and T. Chen, 2004. N-ethyl-N-nitrosourea (ENU) increased brain mutations in prenatal and neonatal mice but not in the adults. Toxicol. Sci., 81: 112-120.
    Direct Link  |  

  64. Mittelstaedt, R.A., N. Mei, P.J. Webb, J.G. Shaddock and V.N. Dobrovolsky et al., 2004. Genotoxicity of malachite green and leucomalachite green in female Big Blue B6C3F1 mice. Mutat. Res./Genet. Toxicol. Environ. Mutagen., 561: 127-138.
    CrossRef  |  Direct Link  |  

  65. Mei, N., R.H. Heflich, M.W. Chou and T. Chen, 2004. Mutations induced by the carcinogenic pyrrolizidine alkaloid riddelliine in the liver cII gene of transgenic big blue rats. Chem. Res. Toxicol., 17: 814-818.
    PubMed  |  

  66. Mei, N., M.W. Chou, P.P. Fu, R.H. Heflich and T. Chen, 2004. Differential mutagenicity of riddelliine in liver endothelial and parenchymal cells of transgenic big blue rats. Cancer Lett., 215: 151-158.
    PubMed  |  

  67. Harrington-Brock, K., D.D. Collard and T. Chen, 2003. Bromate induces loss of heterozygosity in the Thymidine kinase gene of L5178Y/Tk+/--3.7.2C mouse lymphoma cells. Mutat. Res., 537: 21-28.
    PubMed  |  

  68. Chen, T., K. Harrington-Brock and M.M. Moore, 2002. Mutant frequency and mutational spectra in the Tk and Hprt genes of N-ethyl-N-nitrosourea-treated mouse lymphoma cells. Environ. Mol. Mutagen., 39: 296-305.
    PubMed  |  

  69. Chen, T., K. Harrington-Brock and M.M. Moore, 2002. Mutant frequencies and loss of heterozygosity induced by N-ethyl-N-nitrosourea in the Thymidine kinase gene of L5178Y/Tk+/--3.7.2C mouse lymphoma cells. Mutagenesis, 17: 105-109.
    PubMed  |  

  70. Chen, T., G.G. da Costa, M.M. Marques, S.D. Shelton, F.A. Beland and M.G. Manjanatha, 2002. Mutations induced by alpha-hydroxytamoxifen in the lacI and cII genes of Big Blue transgenic rats. Carcinogenesis, 23: 1751-1757.
    PubMed  |  

  71. Chen, T., R.A. Mittelstaedt, S.D. Shelton, S.B. Dass, M.G. Manjanatha, D.A. Casciano and R.H. Heflich, 2001. Gene- and tissue-specificity of mutation in Big Blue rats treated with the hepatocarcinogen N-hydroxy-2-acetylaminofluorene. Environ. Mol. Mutagen., 37: 203-214.
    PubMed  |  

  72. Samokyszyn, V.M., T. Chen, K.R. Maddipati, T.J. Franz, P.A. Lehman and R.V. Lloyd, 1995. Free radical oxidation of (E)-retinoic acid by prostaglandin H synthase. Chem. Res. Toxicol., 8: 807-815.
    PubMed  |