Dr. Tsong-Long  Hwang

Dr. Tsong-Long Hwang

Professor
Chang Gung University, Taiwan


Highest Degree
Ph.D. in Pharmacology from National Taiwan University, Taiwan

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Area of Interest:

Pharmacology and Toxicology
100%
Pharmacological Sciences
62%
Pharmacogenetics
90%
Phosphodiesterase
75%
Cell Signaling
55%

Education

2000

Ph.D.

National Taiwan University, Taiwan

Pharmacology

1993

M.S.

Kaohsiung Medical College, Taiwan

Pharmacology

1991

B.S.

Kaohsiung Medical College, Taiwan

Pharmacy

Selected Publications

  1. Yang, S.C. and T.L. Hwang, 2016. The potential impacts of formyl peptide receptor 1 in inflammatory diseases. Front. Biosci. (Elite Ed.), 8: 436-449.
    PubMed  |  Direct Link  |  

  2. Tseng, W.R., C.Y. Huang, Y.Y. Tsai, Y.S. Lin and T.L. Hwang et al., 2016. New cytotoxic and anti-inflammatory steroids from the soft coral Klyxum flaccidum. Bioorg. Med. Chem. Lett., 26: 3253-3257.
    CrossRef  |  PubMed  |  Direct Link  |  

  3. Tsai, Y.F., S.C. Yang and T.L. Hwang, 2016. Formyl peptide receptor modulators: A patent review and potential applications for inflammatory diseases (2012-2015). Expert Opin. Ther. Pat., 3: 1-18.
    CrossRef  |  PubMed  |  Direct Link  |  

  4. Shih, H.C., P.C. Kuo, S.J. Wu, T.L. Hwang and H.Y. Hung et al., 2016. Anti-inflammatory neolignans from the roots of Magnolia officinalis. Bioorg. Med. Chem., 24: 1439-1445.
    CrossRef  |  Direct Link  |  

  5. Shen, D.Y., P.C. Kuo, S.C. Huang, T.L. Hwang and Y.Y. Chan et al., 2016. Constituents from the leaves of Clausena lansium and their anti-inflammatory activity. J. Nat. Med. 10.1007/s11418-016-1033-x.
    CrossRef  |  PubMed  |  Direct Link  |  

  6. Loa, I.W., Y.B. Cheng, C.C. Haung, T.L. Hwang and C.C. Wu et al., 2016. Constituents of the leaves of Pandanus utilis. Nat. Prod. Commun., 11: 173-176.
    Direct Link  |  

  7. Lo, I.W., Y.B. Cheng, Y.J. Hsieh, T.L. Hwang, D.E. Shieh, F.R. Chang and Y.C. Wu, 2016. Chemical constituents and LC-profile of fresh Formosan Lonicera japonica flower buds. Nat. Prod. Commun., 11: 1-4.
    PubMed  |  

  8. Lin, C.W., T.L. Hwang, F.A. Chen, C.H. Huang, H.Y. Hung and T.S. Wu, 2016. Chemical constituents of the rhizomes of Bletilla formosana and their potential anti-inflammatory activity. J. Nat. Prod., 79: 1911-1921.
    CrossRef  |  PubMed  |  Direct Link  |  

  9. Lin, C.J., I.W. Lo, Y.C. Lin, S.Y. Chen and C.T. Chien et al., 2016. Tetranortriterpenes and limonoids from the roots of Aphanamixis polystachya. Molecules, 21: 1167-1167.
    CrossRef  |  PubMed  |  Direct Link  |  

  10. Korinek, M., V.D. Wagh, I.W. Lo, Y.M. Hsu and H.Y. Hsu et al., 2016. Antiallergic phorbol ester from the seeds of Aquilaria malaccensis. Int. J. Mol. Sci., Vol. 17, No. 3. 10.3390/ijms17030398.
    CrossRef  |  Direct Link  |  

  11. Korinek, M., K.M. Chen, Y.H. Jiang, M. El-Shazly and J. Stocker et al., 2016. Anti-allergic potential of Typhonium blumei: Inhibition of degranulation via suppression of PI3K/PLCγ2 phosphorylation and calcium influx. Phytomedicine, 23: 1706-1715.
    CrossRef  |  PubMed  |  Direct Link  |  

  12. Huang, C.Y., Y.J. Tseng, U. Chokkalingam, T.L. Hwang and C.H. Hsu et al., 2016. Bioactive isoprenoid-derived natural products from a dongsha atoll soft coral Sinularia erecta. J. Nat. Prod., 79: 1339-1346.
    CrossRef  |  PubMed  |  Direct Link  |  

  13. Huang, C.Y., C.W. Chang, Y.J. Tseng, J. Lee and P.J. Sung et al., 2016. Bioactive steroids from the formosan soft coral Umbellulifera petasites. Mar. Drugs, 14: 180-180.
    CrossRef  |  PubMed  |  Direct Link  |  

  14. Hsu, Y.M., T.Y. Wu, Y.C. Du, M. El-Shazly and L. Beerhues et al., 2016. 3-Methyl-4,5-dihydro-oxepine, polyoxygenated seco-cyclohexenes and cyclohexenes from Uvaria flexuosa and their anti-inflammatory activity. Phytochemistry, 122: 184-192.
    CrossRef  |  Direct Link  |  

  15. Hsu, Y.M., F.R. Chang, I.W. Lo, K.H. Lai and M. El-Shazly et al., 2016. Zoanthamine-type alkaloids from the zoanthid Zoanthus kuroshio collected in Taiwan and their effects on inflammation. J. Nat. Prod., 79: 2674-2680.
    CrossRef  |  PubMed  |  Direct Link  |  

  16. Cheng, K.C., P.C. Kuo, H.Y. Hung, K.H. Yu and T.L. Hwang et al., 2016. Four new compounds from edible algae Cladosiphon okamuranus and Chlorella sorokiniana and their bioactivities. Phytochem. Lett., 18: 113-116.
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  17. Chen, Y.L., T.L. Hwang, H.P. Yu, J.Y. Fang and K.Y. Chong et al., 2016. Ilex kaushue and its bioactive component 3,5-dicaffeoylquinic acid protected mice from lipopolysaccharide-induced acute lung injury. Sci. Rep., Vol. 6. 10.1038/srep34243.
    CrossRef  |  Direct Link  |  

  18. Chen, P.J., Y.L. Wang, L.M. Kuo, C.F. Lin and C.Y. Chen et al., 2016. Honokiol suppresses TNF-α-induced neutrophil adhesion on cerebral endothelial cells by disrupting polyubiquitination and degradation of IκBα. Sci. Rep., Vol. 6. 10.1038/srep26554.
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  19. Chen, J.Y., C.Y. Huang, Y.S. Lin, T.L. Hwang, W.L. Wang, S.F. Chiou and J.H. Sheu, 2016. Halogenated sesquiterpenoids from the red Alga Laurencia tristicha collected in Taiwan. J. Nat. Prod., 79: 2315-2323.
    CrossRef  |  Direct Link  |  

  20. Chen, C.Y., Y.F. Tsai, W.Y. Chang, S.C. Yang and T.L. Hwang, 2016. Marine natural product inhibitors of neutrophil-associated inflammation. Mar. Drugs, 14: 141-141.
    CrossRef  |  PubMed  |  Direct Link  |  

  21. Chen, C.Y., C.H. Yang, Y.F. Tsai, C.C. Liaw, W.Y. Chang and T.L. Hwang, 2016. Ugonin U stimulates NLRP3 inflammasome activation and enhances inflammasome-mediated pathogen clearance. Redox Biol., 11: 263-274.
    CrossRef  |  Direct Link  |  

  22. Chang, Y.C., T.L. Hwang, J.H. Sheu, Y.C. Wu and P.J. Sung, 2016. New anti-Inflammatory 9,11-secosterols with a rare tricyclo[5,2,1,1]decane ring from a formosan gorgonian Pinnigorgia sp. Mar. Drugs, Vol. 14, No. 12. 10.3390/md14120218.
    CrossRef  |  PubMed  |  Direct Link  |  

  23. Chang, Y.C., N.F. Chen, T.L. Hwang, C.C. Tseng and T.Y. Wu et al., 2016. New marine sterols from an algal-bearing gorgonian coral Pinnigorgia sp. Steroids, 115: 123-129.
    CrossRef  |  PubMed  |  Direct Link  |  

  24. Chang, Y.C., L.M. Kuo, T.L. Hwang, J. Yeh and Z.H. Wen et al., 2016. Pinnisterols A-C, new 9, 11-secosterols from a Gorgonian Pinnigorgia sp. Mar. Drugs, Vol. 14, No. 1. 10.3390/md14010012.
    CrossRef  |  Direct Link  |  

  25. Chang, Y.C., L.M. Kuo, J.H. Su, T.L. Hwang and Y.H. Kuo et al., 2016. Pinnigorgiols A-C, 9,11-secosterols with a rare ring arrangement from a gorgonian coral Pinnigorgia sp. Tetrahedron, 72: 999-1004.
    CrossRef  |  Direct Link  |  

  26. Chang, H.H., Y.C. Chang, W.F. Chen, T.L. Hwang and L.S. Fang et al., 2016. Pubinernoid A and Apo-9'-fucoxanthinone, secondary metabolites from a gorgonian coral Pinnigorgia sp. Nat. Prod. Commun., 11: 707-708.
    PubMed  |  Direct Link  |  

  27. Chang, F.R., S.T. Huang, C.C. Liaw, M.H. Yen and T.L. Hwang et al., 2016. Diterpenes from Grangea maderaspatana. Phytochemistry, 131: 124-129.
    CrossRef  |  PubMed  |  Direct Link  |  

  28. Wang, S.L., T.L. Hwang, M.I. Chung, P.J. Sung, C.W. Shu, M.J. Cheng and J.J. Chen, 2015. New flavones, a 2-(2-phenylethyl)-4H-chromen-4-one derivative, and anti-inflammatory constituents from the stem barks of Aquilaria sinensis. Molecules, 20: 20912-20925.
    CrossRef  |  Direct Link  |  

  29. Tsai, Y.F., H.P. Yu, W.Y. Chang, F.C. Liu, Z.C. Huang and T.L. Hwang, 2015. Sirtinol inhibits neutrophil elastase activity and attenuates lipopolysaccharide-mediated acute lung injury in mice. Scient. Rep., Vol. 5. 10.1038/srep08347.
    CrossRef  |  Direct Link  |  

  30. Tsai, Y.F., H.P. Yu, P.J. Chung, Y.L. Leu, L.M. Kuo, C.Y. Chen and T.L. Hwang, 2015. Osthol attenuates neutrophilic oxidative stress and hemorrhagic shock-induced lung injury via inhibition of phosphodiesterase 4. Free Radical Biol. Med., 89: 387-400.
    CrossRef  |  Direct Link  |  

  31. Tsai, Y.F. and T.L. Hwang, 2015. Neutrophil elastase inhibitors: A patent review and potential applications for inflammatory lung diseases (2010-2014). Expert Opin. Therapeut. Patents, 25: 1145-1158.
    CrossRef  |  Direct Link  |  

  32. Tsai, Y.C., M.L. Yu, M. El-Shazly, L. Beerhues and Y.B. Cheng et al., 2015. Alkaloids from Pandanus amaryllifolius: Isolation and their plausible biosynthetic formation. J. Nat. Prod., 78: 2346-2354.
    CrossRef  |  Direct Link  |  

  33. Thang, T.D., P.C. Kuo, N.T.B. Ngoc, T.L. Hwang and M.L. Yang et al., 2015. Chemical constituents from the fruiting bodies of Hexagonia apiaria and their anti-inflammatory activity. J. Nat. Prod., 78: 2552-2558.
    CrossRef  |  Direct Link  |  

  34. Su, Y.D., T.R. Su, Z.H. Wen, T.L. Hwang and L.S. Fang et al., 2015. Briarenolides K and L, new anti-inflammatory briarane diterpenoids from an octocoral Briareum sp. (Briareidae). Mar. Drugs, 13: 1037-1050.
    CrossRef  |  Direct Link  |  

  35. Lee, C.L., T.L. Hwang, C.Y. Peng, C.J. Chen, C.L. Kuo, W.Y. Chang and Y.C. Wu, 2015. Anti-inflammatory and cytotoxic compounds from Solanum macaonense. Nat. Prod. Commun., 10: 345-348.
    PubMed  |  

  36. Lee, C.L., M.H. Yen, T.L. Hwang, J.C. Yang and C.Y. Peng et al., 2015. Anti-inflammatory and cytotoxic components from Dichrocephala integrifolia. Phytochem. Lett., 12: 237-242.
    CrossRef  |  Direct Link  |  

  37. Kuo, C.Y., Y.C. Chiu, A.Y.L. Lee and T.L. Hwang, 2015. Mitochondrial Lon protease controls ROS-dependent apoptosis in cardiomyocyte under hypoxia. Mitochondrion, 23: 7-16.
    CrossRef  |  Direct Link  |  

  38. Hwang, T.L., W.H. Wang, T.Y. Wang, H.P. Yu and P.W. Hsieh, 2015. Synthesis and pharmacological characterization of 2-aminobenzaldehyde oxime analogs as dual inhibitors of neutrophil elastase and proteinase 3. Bioorg. Med. Chem., 23: 1123-1134.
    CrossRef  |  Direct Link  |  

  39. Hwang, T.L., I.A. Aljuffali, C.F. Lin, Y.T. Chang and J.Y. Fang, 2015. Cationic additives in nanosystems activate cytotoxicity and inflammatory response of human neutrophils: Lipid nanoparticles versus polymeric nanoparticles. Int. J. Nanomed., 10: 371-385.
    CrossRef  |  Direct Link  |  

  40. Hwang, T.L., I.A. Aljuffali, C.F. Hung, C.H. Chen and J.Y. Fang, 2015. The impact of cationic solid lipid nanoparticles on human neutrophil activation and formation of Neutrophil Extracellular Traps (NETs). Chemico-Biol. Interact., 235: 106-114.
    CrossRef  |  Direct Link  |  

  41. Hwang, T.L., C.Y. Hsu, I.A. Aljuffali, C.H. Chen, Y.T. Chang and J.Y. Fang, 2015. Cationic liposomes evoke proinflammatory mediator release and Neutrophil Extracellular Traps (NETs) toward human neutrophils. Colloids Surf. B: Biointerfaces, 128: 119-126.
    CrossRef  |  Direct Link  |  

  42. Huang, T.Z., B.W. Chen, C.Y. Huang, T.L. Hwang and C. Uvarani et al., 2015. Eunicellin-based diterpenoids, hirsutalins S-V, from the formosan soft coral Cladiella hirsuta. Mar. Drugs, 13: 2757-2769.
    CrossRef  |  Direct Link  |  

  43. Huang, C.Y., P.J. Sung, C. Uvarani, J.H. Su and M.C. Lu et al., 2015. Glaucumolides A and B, biscembranoids with new structural type from a cultured soft coral Sarcophyton glaucum. Scient. Rep., Vol. 5. 10.1038/srep15624.
    CrossRef  |  PubMed  |  Direct Link  |  

  44. Fang, H.Y., U. Chokkalingam, S.F. Chiou, T.L. Hwang, S.L. Chen, W.L. Wang and J.H. Sheu, 2015. Bioactive chemical constituents from the brown alga Homoeostrichus formosana. Int. J. Mol. Sci., 16: 736-746.
    CrossRef  |  Direct Link  |  

  45. Fang, H.W., Y.R. Liao, T.L. Hwang, P.C. Shieh, K.H. Lee, H.Y. Hung and T.S. Wu, 2015. Total synthesis of cordatanine, structural reassignment of drymaritin and anti-inflammatory activity of synthetic precursors. Bioorg. Med. Chem. Lett., 25: 3822-3824.
    CrossRef  |  Direct Link  |  

  46. Chung, H.M., W.H. Wang, T.L. Hwang, Y.C. Wu and P.J. Sung, 2015. Natural Caryophyllane sesquiterpenoids from Rumphella antipathies. Nat. Prod. Commun., 10: 835-838.
    PubMed  |  

  47. Chung, C.Y., W.L. Kuo, T.L. Hwang, M.I. Chung and J.J. Chen, 2015. Biphenyl-type neolignan derivatives from the twigs of Magnolia denudata and their anti-inflammatory activity. Chem. Biodivers., 12: 1263-1270.
    CrossRef  |  Direct Link  |  

  48. Cheng, H.H., Y.B. Cheng, T.L. Hwang, Y.H. Kuo, C.H. Chen and Y.C. Shen, 2015. Randainins A-D, based on unique diterpenoid architectures, from Callicarpa randaiensis. J. Nat. Prod., 78: 1823-1828.
    CrossRef  |  Direct Link  |  

  49. Chen, Y.R., C.H. Tseng, Y.L. Chen, T.L. Hwang and C.C. Tzeng, 2015. Discovery of Benzo[f]indole-4,9-dione derivatives as new types of anti-inflammatory agents. Int. J. Mol. Sci., 16: 6532-6544.
    CrossRef  |  Direct Link  |  

  50. Chen, J.J., C.K. Yang, Y.H. Kuo, T.L. Hwang and W.L. Kuo et al., 2015. New coumarin derivatives and other constituents from the stem bark of Zanthoxylum avicennae: Effects on neutrophil pro-inflammatory responses. Int. J. Mol. Sci., 16: 9719-9731.
    CrossRef  |  Direct Link  |  

  51. Chen, C.Y., Y.L. Leu, Y. Fang, C.F. Lin and L.M. Kuo et al., 2015. Anti-inflammatory effects of Perilla frutescens in activated human neutrophils through two independent pathways: Src family kinases and calcium. Scient. Rep., Vol. 5. 10.1038/srep18204.
    CrossRef  |  Direct Link  |  

  52. Chen, B.W., Y.Y. Chen, Y.C. Lin, C.Y. Huang and C. Uvarani et al., 2015. Capsisteroids A-F, withanolides from the leaves of Solanum capsicoides. RSC Adv., 5: 88841-88847.
    CrossRef  |  Direct Link  |  

  53. Chen, B.W., C. Uvarani, C.Y. Huang, T.L. Hwang, C.F. Dai and J.H. Sheu, 2015. New anti-inflammatory tocopherol-derived metabolites from the Taiwanese soft coral Cladiella hirsute. Bioorg. Med. Chem. Lett., 25: 92-95.
    CrossRef  |  Direct Link  |  

  54. Chao, C.H., T.Z. Huang, C.Y. Wu, B.W. Chen and C.Y. Huang et al., 2015. Steroidal and α-tocopherylhydroquinone glycosides from two soft corals Cladiella hirsuta and Sinularia nanolobata. RSC Adv., 5: 74256-74262.
    CrossRef  |  Direct Link  |  

  55. Yang, S.C., P.J. Sung, C.F. Lin, J. Kuo, C.Y. Chen and T.L. Hwang, 2014. Anti-inflammatory effects of secondary metabolites of marine Pseudomonas sp. in human neutrophils are through inhibiting P38 MAPK, JNK and calcium pathways. PLoS ONE, Vol. 9. 10.1371/journal.pone.0114761.
    CrossRef  |  Direct Link  |  

  56. Wu, S.J., C.H. Huang, Y.Y. Chan, Y.R. Liao, T.L. Hwang and T.S. Wu, 2014. Two diterpenoids and a cyclopenta[c]pyridine derivative from roots of Salvia digitaloids. Int. J. Mol. Sci., 15: 11566-11577.
    CrossRef  |  Direct Link  |  

  57. Wang, R., Y.Q. Liu, W. Ha, Y.P. Shi and T.L. Hwang et al., 2014. In vitro anti-inflammatory effects of diterpenoids and sesquiterpenoids from traditional Chinese medicine Siegesbeckia pubescens. Bioorg. Med. Chem. Lett., 24: 3944-3947.
    CrossRef  |  Direct Link  |  

  58. Wang, L.H., K.H. Chen, C.F. Dai, T.L. Hwang and W.H. Wang et al., 2014. New cembranoids from the soft coral Sinularia arborea. Nat. Prod. Commun., 9: 361-362.
    PubMed  |  

  59. Tsai, Y.C., Y.B. Cheng, I.W. Lo, H.H. Cheng and C.J. Lin et al., 2014. Seven new sesquiterpenoids from the fruits of Schisandra sphenanthera. Chem. Biodiversity, 11: 1053-1068.
    CrossRef  |  Direct Link  |  

  60. Ting, C.W., T.L. Hwang, I.S. Chen, M.J. Cheng, P.J. Sung, M.H. Yen and J.J. Chen, 2014. Garcimultiflorone G, a novel benzoylphloroglucinol derivative from Garcinia multiflora with inhibitory activity on neutrophil pro‐inflammatory responses. Chem. Biodivers., 11: 819-824.
    CrossRef  |  Direct Link  |  

  61. Tai, C.J., U. Chokkalingam, Y. Cheng, S.P. Shih and M.C. Lu et al., 2014. Krempfielins Q and R, two new eunicellin-based diterpenoids from the soft coral Cladiella krempfi. Int. J. Mol. Sci., 15: 21865-21874.
    CrossRef  |  Direct Link  |  

  62. Su, Y.D., C.H. Cheng, W.F. Chen, Y.C. Chang and Y.H. Chen et al., 2014. Briarenolide J, the first 12-chlorobriarane diterpenoid from an octocoral Briareum sp. (Briareidae). Tetrahedron Lett., 55: 6065-6067.
    CrossRef  |  Direct Link  |  

  63. Shen, D.Y., Y.Y. Chan, T.L. Hwang, S.H. Juang and S.C. Huang et al., 2014. Constituents of the roots of Clausena lansium and their potential anti-inflammatory activity. J. Nat. Prod., 77: 1215-1223.
    CrossRef  |  Direct Link  |  

  64. Liou, J.R., T.Y. Wu, T.D. Thang, T.L. Hwang and C.C. Wu et al., 2014. Bioactive 6S-styryllactone constituents of Polyalthia parviflora. J. Nat. Prod., 77: 2626-2632.
    CrossRef  |  Direct Link  |  

  65. Lin, K.H., Y.J. Tseng, B.W. Chen, T.L. Hwang, H.Y. Chen, C.F. Dai and J.H. Sheu, 2014. Tortuosenes A and B, new diterpenoid metabolites from the Formosan soft coral Sarcophyton tortuosum. Org. Lett., 16: 1314-1317.
    CrossRef  |  Direct Link  |  

  66. Liaw, C.C., Y.B. Cheng, Y.S. Lin, Y.H. Kuo, T.L. Hwang and Y.C. Shen, 2014. New briarane diterpenoids from Taiwanese soft coral Briareum violacea. Mar Drugs, 12: 4677-4692.
    CrossRef  |  Direct Link  |  

  67. Lee, Y.N., C.J. Tai, T.L. Hwang and J.H. Sheu, 2014. Krempfielins N-P, new anti-inflammatory eunicellins from a taiwanese soft coral Cladiella krempfi. Mar. Drugs, 12: 1148-1156.
    CrossRef  |  Direct Link  |  

  68. Lee, T.H., Y.C. Chen, T.L. Hwang, C.W. Shu and P.J. Sung et al., 2014. New coumarins and anti-inflammatory constituents from the fruits of Cnidium monnieri. Int. J. Mol. Sci., 15: 9566-9578.
    CrossRef  |  Direct Link  |  

  69. Lee, C.L., T.L. Hwang, J.C. Yang, H.T. Cheng and W.J. He et al., 2014. Anti-inflammatory spirostanol and furostanol saponins from Solanum macaonense. J. Nat. Prod., 77: 1770-1783.
    CrossRef  |  Direct Link  |  

  70. Kuo, P.C., Y.C. Li, T.L. Hwang, G.H. Ma, M.L.Yang, E.J. Lee and T.S. Wu, 2014. Synthesis and structural characterization of an anti-inflammatory principle purified from Lindera aggregate. Tetrahedron Lett., 55: 108-110.
    CrossRef  |  Direct Link  |  

  71. Kuo, L.M., C.Y. Kuo, C.Y. Lin, M.F. Hung, J.J. Shen and T.L. Hwang, 2014. Intracellular glutathione depletion by oridonin leads to apoptosis in hepatic stellate cells. Molecules, 19: 3327-3344.
    CrossRef  |  Direct Link  |  

  72. Hwang, T.L., H.I. Shen, F.C. Liu, H.I. Tsai, Y.C. Wu, F.R. Chang and H.P. Yu, 2014. Ursolic acid inhibits superoxide production in activated neutrophils and attenuates trauma-hemorrhage shock-induced organ injury in rats. PLoS ONE, Vol. 9. 10.1371/journal.pone.0111365.
    CrossRef  |  Direct Link  |  

  73. Hwang, T.L., C.T. Sung, I.A. Aljuffali, Y.T. Chang and J.Y. Fang, 2014. Cationic surfactants in the form of nanoparticles and micelles elicit different human neutrophil responses: A toxicological study. Colloids Surf. B Biointerfaces, 114: 334-341.
    CrossRef  |  Direct Link  |  

  74. Huang, T.Z., B.W. Chen, C.Y. Huang, T.L. Hwang, C.F. Dai and J.H. Sheu, 2014. Eunicellin-based diterpenoids, hirsutalins N-R, from the formosan soft coral Cladiella hirsute. Mar. Drugs, 12: 2446-2457.
    CrossRef  |  Direct Link  |  

  75. Chung, H.M., W.H. Wang, T.L. Hwang, L.S. Fang and Z.H. Wen et al., 2014. Rumphellaoic acid A, a novel sesquiterpenoid from the formosan gorgonian coral Rumphella antipathies. Mar. Drugs, 12: 5856-5863.
    CrossRef  |  Direct Link  |  

  76. Chung, H.M., W.H. Wang, T.L. Hwang, J.J. Li, L.S. Fang, Y.C. Wu and P.J. Sung, 2014. Rumphellaones B and C, new 4,5-seco-caryophyllane sesquiterpenoids from Rumphella antipathies. Molecules, 19: 12320-12327.
    CrossRef  |  Direct Link  |  

  77. Chung, H.M., W.H. Wang, T.L. Hwang, J.J. Chen and L.S. Fang et al., 2014. Rumphellols A and B, new caryophyllene sesquiterpenoids from a formosan gorgonian coral, Rumphella antipathies. Int. J. Mol. Sci., 15: 15679-15688.
    CrossRef  |  Direct Link  |  

  78. Chen, K.H., C.F. Dai, T.L. Hwang, C.Y. Chen and J.J. Li et al., 2014. Discovery of novel diterpenoids from Sinularia arborea. Mar. Drugs, 12: 385-393.
    CrossRef  |  Direct Link  |  

  79. Chen, K.H., C.F. Dai, T.L. Hwang and P.J. Sung, 2014. 5-(6-Hydroxy-2,5,7,8-tetramethylchroman-2-yl)-2-methyl-pentanoic acid methyl ester. Molbank, Vol. 2014. 10.3390/M822.
    CrossRef  |  Direct Link  |  

  80. Chen, I.H., Y.C. Du, T.L. Hwang, I.F. Chen and Y.H. Lan et al., 2014. Anti-inflammatory triterpenoids from the stems of microtropis fokienensis. Molecules, 19: 4608-4623.
    CrossRef  |  Direct Link  |  

  81. Chen, C.Y., C.C. Liaw, Y.H. Chen, W.Y. Chang, P.J. Chung and T.L. Hwang, 2014. A novel immunomodulatory effect of ugonin U in human neutrophils via stimulation of phospholipase C. Free Radic. Biol. Med., 72: 222-231.
    CrossRef  |  Direct Link  |  

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  250. Sheu, J.H., Y.P. Chen, T.L. Hwang, M.Y. Chiang, L.S. Fang and P.J. Sung, 2006. Junceellolides JL, 11, 20-epoxybriaranes from the gorgonian coral Junceella fragilis. J. Nat. Prod., 69: 269-273.
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  251. Leu, Y.L., T.L. Hwang, Y.M. Chung and P.Y. Hong, 2006. The inhibition of superoxide anion generation in human neutrophils by Viscum coloratum. Chem. Pharm. Bull., 54: 1063-1066.
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  252. Leu, Y.L., T.L. Hwang, Y.M. Chung and P.Y. Hong, 2006. The inhibition of superoxide anion generation in human neutrophils by Viscum coloratum. Chem. Pharm. Bull. (Tokyo), 54: 1063-1066.
    PubMed  |  

  253. Hwang, T.L., Y.L. Leu, S.H. Kao, M.C. Tang and H.L. Chang, 2006. Viscolin, a new chalcone from Viscum coloratum, inhibits human neutrophil superoxide anion and elastase release via a cAMP-dependent pathway. Free Radical Biol. Med., 41: 1433-1441.
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  254. Hwang, T.L., S.H. Yeh, Y.L. Leu, C.Y. Chern and H.C. Hsu, 2006. Inhibition of superoxide anion and elastase release in human neutrophils by 3'-isopropoxychalcone via a cAMP‐dependent pathway. Br. J. Pharmacol., 148: 78-87.
    CrossRef  |  Direct Link  |  

  255. Hsieh, H.L., C.Y. Wu, T.L. Hwang, M.H. Yen, P. Parker and C.M. Yang, 2006. BK-induced cytosolic phospholipase A2 expression via sequential PKC‐δ, p42/p44 MAPK and NF‐κB activation in rat brain astrocytes. J. Cell. Physiol., 206: 246-254.
    CrossRef  |  Direct Link  |  

  256. Fang, J.Y., T.L. Hwang, Y.L. Huang and C.L. Fang, 2006. Enhancement of the transdermal delivery of catechins by liposomes incorporating anionic surfactants and ethanol. Int. J. Pharm., 310: 131-138.
    CrossRef  |  Direct Link  |  

  257. Fang, J.Y., T.L. Hwang and Y.L. Huang, 2006. Liposomes as vehicles for enhancing drug delivery via skin routes. Curr. Nanosci., 2: 55-70.
    Direct Link  |  

  258. Chen, Y.P., S.L. Wu, J.H. Su, M.R. Lin and W.P. Hu et al., 2006. Briaexcavatins G and H, two new briaranes from the octocoral Briareum excavatum. Bull. Chem. Soc. Japan, 79: 1900-1905.
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  259. Chang, F.R., T.L. Hwang, Y.L. Yang, C.E. Li and C.C. Wu et al., 2006. Anti-inflammatory and cytotoxic diterpenes from formosan Polyalthia longifolia var. pendula. Planta Med., 72: 1344-1347.
    PubMed  |  

  260. Yeh, S.H., F.R. Chang, Y.C. Wu, Y.L. Yang, S.K. Zhuo and T.L. Hwang, 2005. An anti-inflammatory ent-kaurane from the stems of Annona squamosa that inhibits various human neutrophil functions. Planta Med., 71: 904-909.

  261. Wang, H.P., T.L. Hwang, O. Lee, Y.J. Tseng, C.Y. Shu and S.J. Lee, 2005. Selective cytotoxicity of azatyrosinamides against ras-transformed NIH 3T3 cells. Bioorganic Med. Chem. Lett., 15: 4272-4274.
    CrossRef  |  Direct Link  |  

  262. Lan, Y.H., Y.C. Chia, F.R. Chang, T.L. Hwang, C.C. Liaw and Y.C. Wu, 2005. Potential Anti‐Inflammatory Activities of Bractelactone and other Compounds Isolated from Fissistigma bracteolatum. Helvetica Chim. Acta, 88: 905-909.
    CrossRef  |  Direct Link  |  

  263. Hwang, T.L., Y.C. Wu, S.H. Yeh and R.Y. Kuo, 2005. Suppression of respiratory burst in human neutrophils by new synthetic pyrrolo-benzylisoquinolines. Biochem. Pharmacol., 69: 65-71.
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  264. Hung, C.F., T.L. Hwang, C.C. Chang and J.Y. Fang, 2005. Physicochemical characterization and gene transfection efficiency of lipid emulsions with various co-emulsifiers. Int. J. Pharm., 289: 197-208.
    CrossRef  |  PubMed  |  

  265. Hsieh, P.W., T.L. Hwang, C.C. Wu, F.R. Chang, T.W. Wang and Y.C. Wu, 2005. The evaluation of 2, 8-disubstituted benzoxazinone derivatives as anti-inflammatory and anti-platelet aggregation agents. Bioorganic Med. Chem. Lett., 15: 2786-2789.
    CrossRef  |  Direct Link  |  

  266. Fang, J.Y., C.F. Hung, T.L. Hwang and Y.L. Huang, 2005. Physicochemical characteristics and in vivo deposition of liposome-encapsulated tea catechins by topical and intratumor administrations. J. Drug Targeting, 13: 19-27.
    CrossRef  |  Direct Link  |  

  267. Fang, J.Y., C.F. Hung, T.L. Hwang and W.W. Wong, 2005. Transdermal delivery of tea catechins by electrically assisted methods. Skin Pharmacol. Physiol., 19: 28-37.
    CrossRef  |  Direct Link  |  

  268. Chen, K.S., P.W. Hsieh, T.L. Hwang, F.R. Chang and Y.C. Wu, 2005. Anti-inflammatory furanogermacrane sesquiterpenes from Neolitsea parvigemma. Nat. Prod. Res., 19: 283-286.
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  269. Yang, Y.L., F.R. Chang, T.L. Hwang, W.T. Chang and Y.C. Wu, 2004. Inhibitory effects of ent-kauranes from the stems of Annona squamosa on superoxide anion generation by human neutrophils. Planta Med., 70: 256-258.

  270. Leu, Y.L., S.M. Kuo, T.L. Hwang and S.T. Chiu, 2004. The inhibition of superoxide anion generation by neutrophils from Viscum articulactum. Chem. Pharm. Bull., 52: 858-860.
    CrossRef  |  

  271. Hsieh, P.W., F.R. Chang, K.H. Lee, T.L. Hwang, S.M. Chang and Y.C. Wu, 2004. A new anti-HIV alkaloid, drymaritin and a new C-glycoside flavonoid, diandraflavone, from Drymaria diandra. J. Nat. Prod., 67: 1175-1177.
    CrossRef  |  Direct Link  |  

  272. Fang, J.Y., Y.L. Leu, T.L. Hwang and H.C. Cheng, 2004. Essential oils from sweet basil (Ocimum basilicum) as novel enhancers to accelerate transdermal drug delivery. Biol. Pharm. Bull., 27: 1819-1825.
    Direct Link  |  

  273. Wu, C.C., T.L. Hwang, C.H. Liao, S.C. Kuo, F.Y. Lee, C.M. Teng, 2003. The role of PAR4 in thrombin-induced thromboxane production in human platelets. Thromb. Haemost., 90: 299-308.

  274. Hwang, T.L., H.W. Hung, S.H. Kao, C.M. Teng, C.C. Wu and S.J. Cheng, 2003. Soluble guanylyl cyclase activator YC-1 inhibits human neutrophil functions through a cGMP-independent but cAMP-dependent pathway. Mol. Pharmacol., 64: 1419-1427.
    CrossRef  |  Direct Link  |  

  275. Hwang, T.L., C.C. Wu, J.H. Guh and C.M. Teng, 2003. Potentiation of tumor necrosis factor-α expression by YC-1 in alveolar macrophages through a cyclic GMP-independent pathway. Biochem. Pharmacol., 66: 149-156.
    CrossRef  |  

  276. Fang, J.Y., Y.L. Leu, T.L. Hwang, H.C. Cheng and C.F. Hung, 2003. Development of sesquiterpenes from Alpinia oxyphylla as novel skin permeation enhancers. Eur. J. Pharm. Sci., 19: 253-262.
    CrossRef  |  Direct Link  |  

  277. Fang, J.Y., T.L. Hwang, C.L. Fang and H.C. Chiu, 2003. In vitro and in vivo evaluations of the efficacy and safety of skin permeation enhancers using flurbiprofen as a model drug. Int. J. Pharm., 255: 153-166.
    CrossRef  |  Direct Link  |  

  278. Fang, J.Y., T.L. Hwang and Y.L. Leu, 2003. Effect of enhancers and retarders on percutaneous absorption of flurbiprofen from hydrogels. Int. J. Pharm., 250: 313-325.
    CrossRef  |  Direct Link  |  

  279. Chang, F.R., C.C. Wu, T.L. Hwang, R. Patnam and R.Y. Kuo et al., 2003. Effect of active synthetic 2-substituted quinazolinones on anti-platelet aggregation and the inhibition of superoxide anion generation by neutrophils. Arch. Pharm. Res., 26: 511-515.
    CrossRef  |  Direct Link  |  

  280. Yau, K.I. and T.L. Hwang, 2002. The nonadrenergic noncholinergic system can modulate the effect of prokinetic agents on contractile response of isolated guinea-pig trachea segments to electrical field stimulation. J. Formos Med. Assoc., 101: 695-699.

  281. Wu, C.C., T.L. Hwang, C.H. Liao, S.C. Kuo, F.Y. Lee, C.Y. Lee and C.M. Teng, 2002. Selective inhibition of protease-activated receptor 4-dependent platelet activation by YD-3. Thromb. Haemost., 87: 1026-1033.
    Direct Link  |  

  282. Fang, J.Y., T.L. Hwang, Y.B. Huang and Y.H. Tsai, 2002. Transdermal iontophoresis of sodium nonivamide acetate: V. Combined effect of physical enhancement methods. Int. J. Pharm., 235: 95-105.
    CrossRef  |  Direct Link  |  

  283. Huang, Y.C., J.H. Guh, Z.J. Cheng, Y.L. Chang, T.L. Hwang, C.N. Lin and C.M. Teng, 2001. Inhibitory effect of DCDC on lipopolysaccharide-induced nitric oxide synthesis in RAW 264.7 cells. Life Sci., 68: 2435-27447.
    CrossRef  |  Direct Link  |  

  284. Huang, Y.C., J.H. Guh, Z.J. Cheng, Y.L. Chang and T.L. Hwang et al., 2001. Inhibition of the expression of inducible nitric oxide synthase and cyclooxygenase-2 in macrophages by 7HQ derivatives: Involvement of IkappaB-α stabilization. Eur. J. Pharmacol., 418: 133-139.

  285. Cheng, Z.J., C.N. Lin, T.L. Hwang and C.M. Teng, 2001. Broussochalcone a, a potent antioxidant and effective suppressor of inducible nitric oxide synthase in lipopolysaccharide-activated macrophages. Biochem. Pharmacol., 61: 939-946.
    CrossRef  |  PubMed  |  Direct Link  |  

  286. Wu, S.N., T.L. Hwang, C.M. Teng, H.F. Li and C.R. Jan, 2000. The mechanism of actions of 3-(5'-(hydroxymethyl-2'-furyl)-1-benzyl indazole (YC-1) on Ca2+-activated K+ currents in GH3 lactotrophs. Neuropharmacology, 39: 1788-1799.
    CrossRef  |  Direct Link  |  

  287. Wu, C.C., S.W. Huang, T.L. Hwang, S.C. Kuo, F.Y. Lee and C.M. Teng, 2000. YD-3, a novel inhibitor of protease-induced platelet activation. Br. J. Pharmacol., 130: 1289-1296.
    CrossRef  |  Direct Link  |  

  288. Hwang, T.L., Y.A. Yeh, J.W. Chern and C.M. Teng, 2000. Pharmacological characterization of EK112, a new combined angiotensin II and thromboxane A2 receptor antagonist. Gen. Pharmacol. Vasc. Syst., 34: 25-31.
    CrossRef  |  Direct Link  |  

  289. Hwang, T.L., C.C. Wu and C.M. Teng, 1999. YC-1 potentiates nitric oxide-induced relaxation in guinea-pig trachea. Br. J. Pharmacol., 128: 577-584.
    CrossRef  |  Direct Link  |  

  290. Wu, S.N., S.I. Liu and T.L. Hwang, 1998. Activation of muscarinic K+ channels by extracellular ATP and UTP in rat atrial myocytes. J. Cardiovasc. Pharmacol., 31: 203-211.
    Direct Link  |  

  291. Hwang, T.L., C.C. Wu and C.M. Teng, 1998. Comparison of two soluble guanylyl cyclase inhibitors, methylene blue and ODQ, on sodium nitroprusside-induced relaxation in guinea-pig trachea. Br. J. Pharmacol., 125: 1158-1163.
    CrossRef  |  Direct Link  |  

  292. Guh, J.H., T.L. Hwang, F.N. Ko, S.C. Chueh, M.K. Lai and C.M. Teng, 1998. Antiproliferative effect in human prostatic smooth muscle cells by nitric oxide donor. Mol. Pharmacol., 53: 467-474.
    CrossRef  |  Direct Link  |  

  293. Guh, J.H., S.C. Chueh, T.L. Hwang, J. Chen and C.M. Teng, 1998. Cell proliferation in human prostatic smooth muscle cells involves the modulation of protein kinase C isozymes. Eur. J. Pharmacol., 359: 281-284.
    CrossRef  |  Direct Link  |  

  294. Wu, S.N., T.L. Hwang, C.R. Jan and C.J. Tseng, 1997. Ionic mechanisms of tetrandrine in cultured rat aortic smooth muscle cells. Eur. J. Pharmacol., 327: 233-238.
    CrossRef  |  Direct Link  |  

  295. Wu, S.N., A.Y. Shen and T.L. Hwang, 1996. Analysis of mechanical restitution and post-rest potentiation in isolated rat atrium. Chin. J. Physiol., 39: 23-29.

  296. Wu, B.N., T.L. Hwang, C.F. Liao and I.J. Chen, 1994. Vaninolol: A new selective β1-adrenoceptor antagonist derived from vanillin. Biochem. Pharmacol., 48: 101-109.
    CrossRef  |  Direct Link  |