Dr. Tsong-Long Hwang
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Dr. Tsong-Long Hwang

Professor
Chang Gung University, Taiwan


Highest Degree
Ph.D. in Pharmacology from National Taiwan University, Taiwan

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Area of Interest:

Pharmacology and Toxicology
100%
Pharmacological Sciences
62%
Pharmacogenetics
90%
Phosphodiesterase
75%
Cell Signaling
55%

Research Publications in Numbers

Books
0
Chapters
1
Articles
493
Abstracts
6

Selected Publications

  1. Yang, S.C. and T.L. Hwang, 2016. The potential impacts of formyl peptide receptor 1 in inflammatory diseases. Front. Biosci. (Elite Ed.), 8: 436-449.
    PubMed  |  Direct Link  |  
  2. Tseng, W.R., C.Y. Huang, Y.Y. Tsai, Y.S. Lin and T.L. Hwang et al., 2016. New cytotoxic and anti-inflammatory steroids from the soft coral Klyxum flaccidum. Bioorg. Med. Chem. Lett., 26: 3253-3257.
    CrossRef  |  PubMed  |  Direct Link  |  
  3. Tsai, Y.F., S.C. Yang and T.L. Hwang, 2016. Formyl peptide receptor modulators: A patent review and potential applications for inflammatory diseases (2012-2015). Expert Opin. Ther. Pat., 3: 1-18.
    CrossRef  |  PubMed  |  Direct Link  |  
  4. Shih, H.C., P.C. Kuo, S.J. Wu, T.L. Hwang and H.Y. Hung et al., 2016. Anti-inflammatory neolignans from the roots of Magnolia officinalis. Bioorg. Med. Chem., 24: 1439-1445.
    CrossRef  |  Direct Link  |  
  5. Shen, D.Y., P.C. Kuo, S.C. Huang, T.L. Hwang and Y.Y. Chan et al., 2016. Constituents from the leaves of Clausena lansium and their anti-inflammatory activity. J. Nat. Med. 10.1007/s11418-016-1033-x.
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  6. Loa, I.W., Y.B. Cheng, C.C. Haung, T.L. Hwang and C.C. Wu et al., 2016. Constituents of the leaves of Pandanus utilis. Nat. Prod. Commun., 11: 173-176.
    Direct Link  |  
  7. Lo, I.W., Y.B. Cheng, Y.J. Hsieh, T.L. Hwang, D.E. Shieh, F.R. Chang and Y.C. Wu, 2016. Chemical constituents and LC-profile of fresh Formosan Lonicera japonica flower buds. Nat. Prod. Commun., 11: 1-4.
    PubMed  |  
  8. Lin, C.W., T.L. Hwang, F.A. Chen, C.H. Huang, H.Y. Hung and T.S. Wu, 2016. Chemical constituents of the rhizomes of Bletilla formosana and their potential anti-inflammatory activity. J. Nat. Prod., 79: 1911-1921.
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  9. Lin, C.J., I.W. Lo, Y.C. Lin, S.Y. Chen and C.T. Chien et al., 2016. Tetranortriterpenes and limonoids from the roots of Aphanamixis polystachya. Molecules, 21: 1167-1167.
    CrossRef  |  PubMed  |  Direct Link  |  
  10. Korinek, M., V.D. Wagh, I.W. Lo, Y.M. Hsu and H.Y. Hsu et al., 2016. Antiallergic phorbol ester from the seeds of Aquilaria malaccensis. Int. J. Mol. Sci., Vol. 17. 10.3390/ijms17030398.
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  11. Korinek, M., K.M. Chen, Y.H. Jiang, M. El-Shazly and J. Stocker et al., 2016. Anti-allergic potential of Typhonium blumei: Inhibition of degranulation via suppression of PI3K/PLCγ2 phosphorylation and calcium influx. Phytomedicine, 23: 1706-1715.
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  12. Huang, C.Y., Y.J. Tseng, U. Chokkalingam, T.L. Hwang and C.H. Hsu et al., 2016. Bioactive isoprenoid-derived natural products from a dongsha atoll soft coral Sinularia erecta. J. Nat. Prod., 79: 1339-1346.
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  13. Huang, C.Y., C.W. Chang, Y.J. Tseng, J. Lee and P.J. Sung et al., 2016. Bioactive steroids from the formosan soft coral Umbellulifera petasites. Mar. Drugs, 14: 180-180.
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  14. Hsu, Y.M., T.Y. Wu, Y.C. Du, M. El-Shazly and L. Beerhues et al., 2016. 3-Methyl-4,5-dihydro-oxepine, polyoxygenated seco-cyclohexenes and cyclohexenes from Uvaria flexuosa and their anti-inflammatory activity. Phytochemistry, 122: 184-192.
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  15. Hsu, Y.M., F.R. Chang, I.W. Lo, K.H. Lai and M. El-Shazly et al., 2016. Zoanthamine-type alkaloids from the zoanthid Zoanthus kuroshio collected in Taiwan and their effects on inflammation. J. Nat. Prod., 79: 2674-2680.
    CrossRef  |  PubMed  |  Direct Link  |  
  16. Cheng, K.C., P.C. Kuo, H.Y. Hung, K.H. Yu and T.L. Hwang et al., 2016. Four new compounds from edible algae Cladosiphon okamuranus and Chlorella sorokiniana and their bioactivities. Phytochem. Lett., 18: 113-116.
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  17. Chen, Y.L., T.L. Hwang, H.P. Yu, J.Y. Fang and K.Y. Chong et al., 2016. Ilex kaushue and its bioactive component 3,5-dicaffeoylquinic acid protected mice from lipopolysaccharide-induced acute lung injury. Sci. Rep., Vol. 6. 10.1038/srep34243.
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  18. Chen, P.J., Y.L. Wang, L.M. Kuo, C.F. Lin and C.Y. Chen et al., 2016. Honokiol suppresses TNF-α-induced neutrophil adhesion on cerebral endothelial cells by disrupting polyubiquitination and degradation of IκBα. Sci. Rep., Vol. 6. 10.1038/srep26554.
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  19. Chen, J.Y., C.Y. Huang, Y.S. Lin, T.L. Hwang, W.L. Wang, S.F. Chiou and J.H. Sheu, 2016. Halogenated sesquiterpenoids from the red Alga Laurencia tristicha collected in Taiwan. J. Nat. Prod., 79: 2315-2323.
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  20. Chen, C.Y., Y.F. Tsai, W.Y. Chang, S.C. Yang and T.L. Hwang, 2016. Marine natural product inhibitors of neutrophil-associated inflammation. Mar. Drugs, 14: 141-141.
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  21. Chen, C.Y., C.H. Yang, Y.F. Tsai, C.C. Liaw, W.Y. Chang and T.L. Hwang, 2016. Ugonin U stimulates NLRP3 inflammasome activation and enhances inflammasome-mediated pathogen clearance. Redox Biol., 11: 263-274.
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  22. Chang, Y.C., T.L. Hwang, J.H. Sheu, Y.C. Wu and P.J. Sung, 2016. New anti-Inflammatory 9,11-secosterols with a rare tricyclo[5,2,1,1]decane ring from a formosan gorgonian Pinnigorgia sp. Mar. Drugs, Vol. 14, No. 12. 10.3390/md14120218.
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  23. Chang, Y.C., N.F. Chen, T.L. Hwang, C.C. Tseng and T.Y. Wu et al., 2016. New marine sterols from an algal-bearing gorgonian coral Pinnigorgia sp. Steroids, 115: 123-129.
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  24. Chang, Y.C., L.M. Kuo, T.L. Hwang, J. Yeh and Z.H. Wen et al., 2016. Pinnisterols A-C, new 9, 11-secosterols from a Gorgonian Pinnigorgia sp. Mar. Drugs, Vol. 14, No. 1. 10.3390/md14010012.
    CrossRef  |  Direct Link  |  
  25. Chang, Y.C., L.M. Kuo, J.H. Su, T.L. Hwang and Y.H. Kuo et al., 2016. Pinnigorgiols A-C, 9,11-secosterols with a rare ring arrangement from a gorgonian coral Pinnigorgia sp. Tetrahedron, 72: 999-1004.
    CrossRef  |  Direct Link  |  
  26. Chang, H.H., Y.C. Chang, W.F. Chen, T.L. Hwang and L.S. Fang et al., 2016. Pubinernoid A and Apo-9'-fucoxanthinone, secondary metabolites from a gorgonian coral Pinnigorgia sp. Nat. Prod. Commun., 11: 707-708.
    PubMed  |  Direct Link  |  
  27. Chang, F.R., S.T. Huang, C.C. Liaw, M.H. Yen and T.L. Hwang et al., 2016. Diterpenes from Grangea maderaspatana. Phytochemistry, 131: 124-129.
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  28. Wang, S.L., T.L. Hwang, M.I. Chung, P.J. Sung, C.W. Shu, M.J. Cheng and J.J. Chen, 2015. New flavones, a 2-(2-phenylethyl)-4H-chromen-4-one derivative, and anti-inflammatory constituents from the stem barks of Aquilaria sinensis. Molecules, 20: 20912-20925.
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  29. Tsai, Y.F., H.P. Yu, W.Y. Chang, F.C. Liu, Z.C. Huang and T.L. Hwang, 2015. Sirtinol inhibits neutrophil elastase activity and attenuates lipopolysaccharide-mediated acute lung injury in mice. Scient. Rep., Vol. 5. 10.1038/srep08347.
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  30. Tsai, Y.F., H.P. Yu, P.J. Chung, Y.L. Leu, L.M. Kuo, C.Y. Chen and T.L. Hwang, 2015. Osthol attenuates neutrophilic oxidative stress and hemorrhagic shock-induced lung injury via inhibition of phosphodiesterase 4. Free Radical Biol. Med., 89: 387-400.
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  31. Tsai, Y.F. and T.L. Hwang, 2015. Neutrophil elastase inhibitors: A patent review and potential applications for inflammatory lung diseases (2010-2014). Expert Opin. Therapeut. Patents, 25: 1145-1158.
    CrossRef  |  Direct Link  |  
  32. Tsai, Y.C., M.L. Yu, M. El-Shazly, L. Beerhues and Y.B. Cheng et al., 2015. Alkaloids from Pandanus amaryllifolius: Isolation and their plausible biosynthetic formation. J. Nat. Prod., 78: 2346-2354.
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  33. Thang, T.D., P.C. Kuo, N.T.B. Ngoc, T.L. Hwang and M.L. Yang et al., 2015. Chemical constituents from the fruiting bodies of Hexagonia apiaria and their anti-inflammatory activity. J. Nat. Prod., 78: 2552-2558.
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  34. Su, Y.D., T.R. Su, Z.H. Wen, T.L. Hwang and L.S. Fang et al., 2015. Briarenolides K and L, new anti-inflammatory briarane diterpenoids from an octocoral Briareum sp. (Briareidae). Mar. Drugs, 13: 1037-1050.
    CrossRef  |  Direct Link  |  
  35. Lee, C.L., T.L. Hwang, C.Y. Peng, C.J. Chen, C.L. Kuo, W.Y. Chang and Y.C. Wu, 2015. Anti-inflammatory and cytotoxic compounds from Solanum macaonense. Nat. Prod. Commun., 10: 345-348.
    PubMed  |  
  36. Lee, C.L., M.H. Yen, T.L. Hwang, J.C. Yang and C.Y. Peng et al., 2015. Anti-inflammatory and cytotoxic components from Dichrocephala integrifolia. Phytochem. Lett., 12: 237-242.
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  37. Kuo, C.Y., Y.C. Chiu, A.Y.L. Lee and T.L. Hwang, 2015. Mitochondrial Lon protease controls ROS-dependent apoptosis in cardiomyocyte under hypoxia. Mitochondrion, 23: 7-16.
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  38. Hwang, T.L., W.H. Wang, T.Y. Wang, H.P. Yu and P.W. Hsieh, 2015. Synthesis and pharmacological characterization of 2-aminobenzaldehyde oxime analogs as dual inhibitors of neutrophil elastase and proteinase 3. Bioorg. Med. Chem., 23: 1123-1134.
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  39. Hwang, T.L., I.A. Aljuffali, C.F. Lin, Y.T. Chang and J.Y. Fang, 2015. Cationic additives in nanosystems activate cytotoxicity and inflammatory response of human neutrophils: Lipid nanoparticles versus polymeric nanoparticles. Int. J. Nanomed., 10: 371-385.
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  40. Hwang, T.L., I.A. Aljuffali, C.F. Hung, C.H. Chen and J.Y. Fang, 2015. The impact of cationic solid lipid nanoparticles on human neutrophil activation and formation of Neutrophil Extracellular Traps (NETs). Chemico-Biol. Interact., 235: 106-114.
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  41. Hwang, T.L., C.Y. Hsu, I.A. Aljuffali, C.H. Chen, Y.T. Chang and J.Y. Fang, 2015. Cationic liposomes evoke proinflammatory mediator release and Neutrophil Extracellular Traps (NETs) toward human neutrophils. Colloids Surf. B: Biointerfaces, 128: 119-126.
    CrossRef  |  Direct Link  |  
  42. Huang, T.Z., B.W. Chen, C.Y. Huang, T.L. Hwang and C. Uvarani et al., 2015. Eunicellin-based diterpenoids, hirsutalins S-V, from the formosan soft coral Cladiella hirsuta. Mar. Drugs, 13: 2757-2769.
    CrossRef  |  Direct Link  |  
  43. Huang, C.Y., P.J. Sung, C. Uvarani, J.H. Su and M.C. Lu et al., 2015. Glaucumolides A and B, biscembranoids with new structural type from a cultured soft coral Sarcophyton glaucum. Scient. Rep., Vol. 5. 10.1038/srep15624.
    CrossRef  |  PubMed  |  Direct Link  |  
  44. Fang, H.Y., U. Chokkalingam, S.F. Chiou, T.L. Hwang, S.L. Chen, W.L. Wang and J.H. Sheu, 2015. Bioactive chemical constituents from the brown alga Homoeostrichus formosana. Int. J. Mol. Sci., 16: 736-746.
    CrossRef  |  Direct Link  |  
  45. Fang, H.W., Y.R. Liao, T.L. Hwang, P.C. Shieh, K.H. Lee, H.Y. Hung and T.S. Wu, 2015. Total synthesis of cordatanine, structural reassignment of drymaritin and anti-inflammatory activity of synthetic precursors. Bioorg. Med. Chem. Lett., 25: 3822-3824.
    CrossRef  |  Direct Link  |  
  46. Chung, H.M., W.H. Wang, T.L. Hwang, Y.C. Wu and P.J. Sung, 2015. Natural Caryophyllane sesquiterpenoids from Rumphella antipathies. Nat. Prod. Commun., 10: 835-838.
    PubMed  |  
  47. Chung, C.Y., W.L. Kuo, T.L. Hwang, M.I. Chung and J.J. Chen, 2015. Biphenyl-type neolignan derivatives from the twigs of Magnolia denudata and their anti-inflammatory activity. Chem. Biodivers., 12: 1263-1270.
    CrossRef  |  Direct Link  |  
  48. Cheng, H.H., Y.B. Cheng, T.L. Hwang, Y.H. Kuo, C.H. Chen and Y.C. Shen, 2015. Randainins A-D, based on unique diterpenoid architectures, from Callicarpa randaiensis. J. Nat. Prod., 78: 1823-1828.
    CrossRef  |  Direct Link  |  
  49. Chen, Y.R., C.H. Tseng, Y.L. Chen, T.L. Hwang and C.C. Tzeng, 2015. Discovery of Benzo[f]indole-4,9-dione derivatives as new types of anti-inflammatory agents. Int. J. Mol. Sci., 16: 6532-6544.
    CrossRef  |  Direct Link  |  
  50. Chen, J.J., C.K. Yang, Y.H. Kuo, T.L. Hwang and W.L. Kuo et al., 2015. New coumarin derivatives and other constituents from the stem bark of Zanthoxylum avicennae: Effects on neutrophil pro-inflammatory responses. Int. J. Mol. Sci., 16: 9719-9731.
    CrossRef  |  Direct Link  |  
  51. Chen, C.Y., Y.L. Leu, Y. Fang, C.F. Lin and L.M. Kuo et al., 2015. Anti-inflammatory effects of Perilla frutescens in activated human neutrophils through two independent pathways: Src family kinases and calcium. Scient. Rep., Vol. 5. 10.1038/srep18204.
    CrossRef  |  Direct Link  |  
  52. Chen, B.W., Y.Y. Chen, Y.C. Lin, C.Y. Huang and C. Uvarani et al., 2015. Capsisteroids A-F, withanolides from the leaves of Solanum capsicoides. RSC Adv., 5: 88841-88847.
    CrossRef  |  Direct Link  |  
  53. Chen, B.W., C. Uvarani, C.Y. Huang, T.L. Hwang, C.F. Dai and J.H. Sheu, 2015. New anti-inflammatory tocopherol-derived metabolites from the Taiwanese soft coral Cladiella hirsute. Bioorg. Med. Chem. Lett., 25: 92-95.
    CrossRef  |  Direct Link  |  
  54. Chao, C.H., T.Z. Huang, C.Y. Wu, B.W. Chen and C.Y. Huang et al., 2015. Steroidal and α-tocopherylhydroquinone glycosides from two soft corals Cladiella hirsuta and Sinularia nanolobata. RSC Adv., 5: 74256-74262.
    CrossRef  |  Direct Link  |  
  55. Yang, S.C., P.J. Sung, C.F. Lin, J. Kuo, C.Y. Chen and T.L. Hwang, 2014. Anti-inflammatory effects of secondary metabolites of marine Pseudomonas sp. in human neutrophils are through inhibiting P38 MAPK, JNK and calcium pathways. PLoS ONE, Vol. 9. 10.1371/journal.pone.0114761.
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  56. Wu, S.J., C.H. Huang, Y.Y. Chan, Y.R. Liao, T.L. Hwang and T.S. Wu, 2014. Two diterpenoids and a cyclopenta[c]pyridine derivative from roots of Salvia digitaloids. Int. J. Mol. Sci., 15: 11566-11577.
    CrossRef  |  Direct Link  |  
  57. Wang, R., Y.Q. Liu, W. Ha, Y.P. Shi and T.L. Hwang et al., 2014. In vitro anti-inflammatory effects of diterpenoids and sesquiterpenoids from traditional Chinese medicine Siegesbeckia pubescens. Bioorg. Med. Chem. Lett., 24: 3944-3947.
    CrossRef  |  Direct Link  |  
  58. Wang, L.H., K.H. Chen, C.F. Dai, T.L. Hwang and W.H. Wang et al., 2014. New cembranoids from the soft coral Sinularia arborea. Nat. Prod. Commun., 9: 361-362.
    PubMed  |  
  59. Tsai, Y.C., Y.B. Cheng, I.W. Lo, H.H. Cheng and C.J. Lin et al., 2014. Seven new sesquiterpenoids from the fruits of Schisandra sphenanthera. Chem. Biodiversity, 11: 1053-1068.
    CrossRef  |  Direct Link  |  
  60. Ting, C.W., T.L. Hwang, I.S. Chen, M.J. Cheng, P.J. Sung, M.H. Yen and J.J. Chen, 2014. Garcimultiflorone G, a novel benzoylphloroglucinol derivative from Garcinia multiflora with inhibitory activity on neutrophil pro‐inflammatory responses. Chem. Biodivers., 11: 819-824.
    CrossRef  |  Direct Link  |  
  61. Tai, C.J., U. Chokkalingam, Y. Cheng, S.P. Shih and M.C. Lu et al., 2014. Krempfielins Q and R, two new eunicellin-based diterpenoids from the soft coral Cladiella krempfi. Int. J. Mol. Sci., 15: 21865-21874.
    CrossRef  |  Direct Link  |  
  62. Su, Y.D., C.H. Cheng, W.F. Chen, Y.C. Chang and Y.H. Chen et al., 2014. Briarenolide J, the first 12-chlorobriarane diterpenoid from an octocoral Briareum sp. (Briareidae). Tetrahedron Lett., 55: 6065-6067.
    CrossRef  |  Direct Link  |  
  63. Shen, D.Y., Y.Y. Chan, T.L. Hwang, S.H. Juang and S.C. Huang et al., 2014. Constituents of the roots of Clausena lansium and their potential anti-inflammatory activity. J. Nat. Prod., 77: 1215-1223.
    CrossRef  |  Direct Link  |  
  64. Liou, J.R., T.Y. Wu, T.D. Thang, T.L. Hwang and C.C. Wu et al., 2014. Bioactive 6S-styryllactone constituents of Polyalthia parviflora. J. Nat. Prod., 77: 2626-2632.
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  65. Lin, K.H., Y.J. Tseng, B.W. Chen, T.L. Hwang, H.Y. Chen, C.F. Dai and J.H. Sheu, 2014. Tortuosenes A and B, new diterpenoid metabolites from the Formosan soft coral Sarcophyton tortuosum. Org. Lett., 16: 1314-1317.
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  66. Liaw, C.C., Y.B. Cheng, Y.S. Lin, Y.H. Kuo, T.L. Hwang and Y.C. Shen, 2014. New briarane diterpenoids from Taiwanese soft coral Briareum violacea. Mar Drugs, 12: 4677-4692.
    CrossRef  |  Direct Link  |  
  67. Lee, Y.N., C.J. Tai, T.L. Hwang and J.H. Sheu, 2014. Krempfielins N-P, new anti-inflammatory eunicellins from a taiwanese soft coral Cladiella krempfi. Mar. Drugs, 12: 1148-1156.
    CrossRef  |  Direct Link  |  
  68. Lee, T.H., Y.C. Chen, T.L. Hwang, C.W. Shu and P.J. Sung et al., 2014. New coumarins and anti-inflammatory constituents from the fruits of Cnidium monnieri. Int. J. Mol. Sci., 15: 9566-9578.
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  69. Lee, C.L., T.L. Hwang, J.C. Yang, H.T. Cheng and W.J. He et al., 2014. Anti-inflammatory spirostanol and furostanol saponins from Solanum macaonense. J. Nat. Prod., 77: 1770-1783.
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  70. Kuo, P.C., Y.C. Li, T.L. Hwang, G.H. Ma, M.L.Yang, E.J. Lee and T.S. Wu, 2014. Synthesis and structural characterization of an anti-inflammatory principle purified from Lindera aggregate. Tetrahedron Lett., 55: 108-110.
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  71. Kuo, L.M., C.Y. Kuo, C.Y. Lin, M.F. Hung, J.J. Shen and T.L. Hwang, 2014. Intracellular glutathione depletion by oridonin leads to apoptosis in hepatic stellate cells. Molecules, 19: 3327-3344.
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  72. Hwang, T.L., H.I. Shen, F.C. Liu, H.I. Tsai, Y.C. Wu, F.R. Chang and H.P. Yu, 2014. Ursolic acid inhibits superoxide production in activated neutrophils and attenuates trauma-hemorrhage shock-induced organ injury in rats. PLoS ONE, Vol. 9. 10.1371/journal.pone.0111365.
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  73. Hwang, T.L., C.T. Sung, I.A. Aljuffali, Y.T. Chang and J.Y. Fang, 2014. Cationic surfactants in the form of nanoparticles and micelles elicit different human neutrophil responses: A toxicological study. Colloids Surf. B Biointerfaces, 114: 334-341.
    CrossRef  |  Direct Link  |  
  74. Huang, T.Z., B.W. Chen, C.Y. Huang, T.L. Hwang, C.F. Dai and J.H. Sheu, 2014. Eunicellin-based diterpenoids, hirsutalins N-R, from the formosan soft coral Cladiella hirsute. Mar. Drugs, 12: 2446-2457.
    CrossRef  |  Direct Link  |  
  75. Chung, H.M., W.H. Wang, T.L. Hwang, L.S. Fang and Z.H. Wen et al., 2014. Rumphellaoic acid A, a novel sesquiterpenoid from the formosan gorgonian coral Rumphella antipathies. Mar. Drugs, 12: 5856-5863.
    CrossRef  |  Direct Link  |  
  76. Chung, H.M., W.H. Wang, T.L. Hwang, J.J. Li, L.S. Fang, Y.C. Wu and P.J. Sung, 2014. Rumphellaones B and C, new 4,5-seco-caryophyllane sesquiterpenoids from Rumphella antipathies. Molecules, 19: 12320-12327.
    CrossRef  |  Direct Link  |  
  77. Chung, H.M., W.H. Wang, T.L. Hwang, J.J. Chen and L.S. Fang et al., 2014. Rumphellols A and B, new caryophyllene sesquiterpenoids from a formosan gorgonian coral, Rumphella antipathies. Int. J. Mol. Sci., 15: 15679-15688.
    CrossRef  |  Direct Link  |  
  78. Chen, K.H., C.F. Dai, T.L. Hwang, C.Y. Chen and J.J. Li et al., 2014. Discovery of novel diterpenoids from Sinularia arborea. Mar. Drugs, 12: 385-393.
    CrossRef  |  Direct Link  |  
  79. Chen, K.H., C.F. Dai, T.L. Hwang and P.J. Sung, 2014. 5-(6-Hydroxy-2,5,7,8-tetramethylchroman-2-yl)-2-methyl-pentanoic acid methyl ester. Molbank, Vol. 2014. 10.3390/M822.
    CrossRef  |  Direct Link  |  
  80. Chen, I.H., Y.C. Du, T.L. Hwang, I.F. Chen and Y.H. Lan et al., 2014. Anti-inflammatory triterpenoids from the stems of microtropis fokienensis. Molecules, 19: 4608-4623.
    CrossRef  |  Direct Link  |  
  81. Chen, C.Y., C.C. Liaw, Y.H. Chen, W.Y. Chang, P.J. Chung and T.L. Hwang, 2014. A novel immunomodulatory effect of ugonin U in human neutrophils via stimulation of phospholipase C. Free Radic. Biol. Med., 72: 222-231.
    CrossRef  |  Direct Link  |  
  82. Chao, C.H., J.C. Cheng, T.L. Hwang, D.Y. Shen and T.S. Wu, 2014. Trinorditerpenes from the roots of Flueggea virosa. Bioorg. Med. Chem. Lett., 24: 447-449.
    CrossRef  |  Direct Link  |  
  83. Yu, H.P., F.C. Liu, Y.F. Tsai and T.L. Hwang, 2013. Osthole attenuates hepatic injury in a rodent model of trauma-hemorrhage. PLoS One, Vol. 8. 10.1371/journal.pone.0065916.
    CrossRef  |  Direct Link  |  
  84. Yang, S.C., P.J. Chung, C.M. Ho, C.Y. Kuo and M.F. Hung et al., 2013. Propofol inhibits superoxide production, elastase release and chemotaxis in formyl peptide-activated human neutrophils by blocking formyl peptide receptor 1. J. Immunol., 190: 6511-6519.
    CrossRef  |  Direct Link  |  
  85. Yang, S.C., C.F. Lin, W.Y. Chang, J. Kuo, Y.T. Huang, P.J. Chung and T.L. Hwang, 2013. Bioactive secondary metabolites of a marine Bacillus sp. inhibit superoxide generation and elastase release in human neutrophils by blocking formyl peptide receptor 1. Molecules, 18: 6455-6468.
    CrossRef  |  Direct Link  |  
  86. Yang, H.W., M.Y. Hua, T.L. Hwang, K.J. Lin and C.Y. Huang et al., 2013. Non-invasive synergistic treatment of brain tumors by targeted chemotherapeutic delivery and amplified focused ultrasound-hyperthermia using magnetic nanographene oxide. Adv. Mater., 25: 3605-3611.
    CrossRef  |  Direct Link  |  
  87. Wu, Y.C., M. Sureshbabu, Y.C. Fang, Y.H. Wu and Y.H. Lan et al., 2013. Potent inhibition of human neutrophil activations by bractelactone, a novel chalcone from Fissistigma bracteolatum. Toxicol. Applied Pharmacol., 266: 399-407.
    CrossRef  |  
  88. Wu, T.Y., Y.C. Du, Y.M. Hsu, C.Y. Lu, A.N.B. Singab, M. El-Shazly and F.R. Chang, 2013. New approach to the characterization and quantification of antrodia cinnamomea benzenoid components utilizing hplc-pda, qnmr and hplc-tandem ms: comparing the wild fruiting bodies and its artificial cultivated commercial products. Food Res. Int., 51: 23-31.
    CrossRef  |  Direct Link  |  
  89. Thang, T.D., P.C. Kuo, T.L. Hwang, M.L. Yang and N.T.B. Ngoc et al., 2013. Triterpenoids and steroids from Ganoderma mastoporum and their inhibitory effects on superoxide anion generation and elastase release. Molecules, 18: 14285-14292.
    CrossRef  |  Direct Link  |  
  90. Shih, H.C., T.L. Hwang, H.C. Chen, P.C. Kuo, E.J. Lee, K.H. Lee and T.S. Wu, 2013. Honokiol dimers and magnolol derivatives with new carbon skeletons from the roots of magnolia officinalis and their inhibitory effects on superoxide anion generation and elastase release. PLoS One, Vol. 8. 10.1371/journal.pone.0059502.
    CrossRef  |  Direct Link  |  
  91. Liou, J.R., M. El-Shazly, Y.C. Du, C.N. Tseng and T.L. Hwang et al., 2013. 1,5-Diphenylpent-3-en-1-ynes and methyl naphthalene carboxylates from Lawsonia inermis and their anti-inflammatory activity. Phytochemistry, 88: 67-73.
    CrossRef  |  Direct Link  |  
  92. Lin, Y.K., H.W. Chen, Y.L. Leu, Y.L. Yang, Y. Fang and T.L. Hwang, 2013. Indigo naturalis upregulates claudin-1 expression in human keratinocytes and psoriatic lesions. J. Ethnopharmacol., 145: 614-620.
    CrossRef  |  
  93. Lin, M.C., B.W. Chen, C.Y. Huang, C.F. Dai, T.L. Hwang and J.H. Sheu, 2013. Eunicellin-based diterpenoids from the Formosan soft coral Klyxum molle with inhibitory activity on superoxide generation and elastase release by neutrophils. J. Nat. Prod., 76: 1661-1667.
    CrossRef  |  Direct Link  |  
  94. Lin, C.F., T.L. Hwang, S.A. Al-Suwayeh, Y.L. Huang, Y.Y. Hung and J.Y. Fang, 2013. Maximizing dermal targeting and minimizing transdermal penetration by magnolol/honokiol methoxylation. Int. J. Pharm., 445: 153-162.
    CrossRef  |  Direct Link  |  
  95. Lin, C.F., T.L. Hwang, C.C. Chien, H.Y. Tu and H.L. Lay, 2013. A new hydroxychavicol dimer from the roots of Piper betle. Molecules, 18: 2563-2570.
    CrossRef  |  
  96. Liaw, C.C., Y.C. Lin, Y.S. Lin, C.H. Chen, T.L. Hwang and Y.C. Shen, 2013. Four new briarane diterpenoids from Taiwanese gorgonian Junceella fragilis. Mar. Drugs, 11: 2042-2053.
    CrossRef  |  Direct Link  |  
  97. Lee, Y.N., C.J. Tai, T.L. Hwang and J.H. Sheu, 2013. Krempfielins J-M, new eunicellin-based diterpenoids from the soft coral Cladiella krempfi. Mar. Drugs, 11: 2741-2750.
    CrossRef  |  Direct Link  |  
  98. Lee, C.L., T.L. Hwang, W.J. He, Y.H. Tsai and C.T. Yen et al., 2013. Anti-neutrophilic inflammatory steroidal glycosides from Solanum torvum. Phytochemistry, 95: 315-321.
    CrossRef  |  Direct Link  |  
  99. Lai, W.C., Y.T. Tsui, A.N.B. Singab, M. El-Shazly and Y.C. Du et al., 2013. Phyto-serm constitutes from Flemingia macrophylla. Int. J. Mol. Sci., 14: 15578-15594.
    CrossRef  |  Direct Link  |  
  100. Kuo, W.L., C.Y. Chung, T.L. Hwang and J.J. Chen, 2013. Biphenyl-type neolignans from Magnolia officinalis and their anti-inflammatory activities. Phytochemistry, 85: 153-160.
    CrossRef  |  Direct Link  |  
  101. Kuo, P.C., M.L. Yang, T.L. Hwang, Y.Y. Lai, Y.C. Li, T.D. Thang and T.S. Wu, 2013. Anti-inflammatory diterpenoids from Croton tonkinensis. J. Nat. Prod., 76: 230-236.
    CrossRef  |  Direct Link  |  
  102. Kuo, C.Y., T.Y. Chou, C.M. Chen, G.Y. Hwang and T.L. Hwang, 2013. Hepatitis B virus X protein disrupts stress fiber formation and triggers apoptosis. Virus Res., 175: 20-29.
    CrossRef  |  Direct Link  |  
  103. Hwang, T.L., C.H. Hung, C.Y. Hsu, Y.T. Huang, Y.C. Tsai and P.W. Hsieh, 2013. Design and synthesis of tryptophan containing dipeptide derivatives as formyl peptide receptor 1 antagonist. Org. Biomol. Chem., 11: 3742-3755.
    CrossRef  |  Direct Link  |  
  104. Huang, S.C., P.C. Kuo, T.L. Hwang, Y.Y. Chan, C.H. Chen and T.S. Wu, 2013. Three novel sesquiterpenes from the mycelium of Phellinus linteus. Tetrahedron Lett., 54: 3332-3335.
    CrossRef  |  Direct Link  |  
  105. Huang, H.C., M.K. Lin, S.Y. Hwang, T.L. Hwang and Y.H. Kuo et al., 2013. Two anti-inflammatory steroidal saponins from Dracaena angustifolia Roxb. Molecules, 18: 8752-8763.
    CrossRef  |  Direct Link  |  
  106. Hu, L.C., J.H. Su, M.Y. Chiang, M.C. Lu and T.L. Hwang et al., 2013. Flexibilins A-C, new cembrane-type diterpenoids from the formosan soft coral, Sinularia flexibilis. Mar. Drugs, 11: 1999-2012.
    CrossRef  |  Direct Link  |  
  107. Chung, Y.M., M. El-Shazly, D.W. Chuang, T.L. Hwang and T. Asai et al., 2013. Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, induces the production of anti-inflammatory cyclodepsipeptides from Beauveria felina. J. Nat. Prod., 76: 1260-1266.
    CrossRef  |  Direct Link  |  
  108. Chung, Y.M., C.K. Wei, D.W. Chuang, M. El-Shazly and C.T. Hsieh et al., 2013. An epigenetic modifier enhances the production of anti-diabetic and anti-inflammatory sesquiterpenoids from Aspergillus sydowii. Bioorg. Med. Chem., 21: 3866-3872.
    CrossRef  |  Direct Link  |  
  109. Chung, H.M., W.H. Wang, T.L. Hwang, Y.C. Wu and P.J. Sung, 2013. Natural clovanes from the gorgonian coral Rumphella antipathies. Nat. Prod. Commun., 8: 1037-1040.
    PubMed  |  
  110. Chung, H.M., J.H. Su, T.L. Hwang, J.J. Li and J.J. Chen et al., 2013. Rumphellclovanes C-E, new clovane-type sesquiterpenoids from the gorgonian coral Rumphella antipathies. Tetrahedron, 69: 2740-2744.
    CrossRef  |  Direct Link  |  
  111. Chung, C.Y., T.L. Hwang, L.M. Kuo, W.L. Kuo and M.J. Cheng et al., 2013. New Benzo[c]phenanthridine and benzenoid derivatives and other constituents from Zanthoxylum ailanthoides: Effects on neutrophil pro-inflammatory responses. Int. J. Mol. Sci., 14: 22395-22408.
    CrossRef  |  Direct Link  |  
  112. Chen, J.J., C.W. Ting, Y.C. Wu, T.L. Hwang and M.J. Cheng et al., 2013. New Labdane-type diterpenoids and anti-inflammatory constituents from Hedychium coronarium. Int. J. Mol. Sci., 14: 13063-13077.
    CrossRef  |  Direct Link  |  
  113. Chan, S.H., W.J. Leu, L.C. Hsu, H.S. Chang and T.L. Hwang et al., 2013. Reevesioside F induces potent and efficient anti-proliferative and apoptotic activities through Na+/K+-ATPase α3 subunit-involved mitochondrial stress and amplification of caspase cascades. Biochem. Pharmacol., 86: 1564-1575.
    CrossRef  |  Direct Link  |  
  114. Chan, H.H., T.L. Hwang, T.D. Thang, Y.L. Leu and P.C. Kuo et al., 2013. Isolation and synthesis of melodamide a, a new anti-inflammatory phenolic amide from the leaves of Melodorum fruticosum. Planta Med., 79: 288-294.
  115. Yen, C.T., K. Nakagawa-Goto, T.L. Hwang, S.L. Morris-Natschke, K.F. Bastow, Y.C. Wu and K.H. Lee, 2012. Design and synthesis of gambogic acid analogs as potent cytotoxic and anti-inflammatory agents. Bioorg. Med. Chem. Lett., 22: 4018-4022.
    CrossRef  |  Direct Link  |  
  116. Yen, C.T., C.L. Lee, F.R. Chang, T.L. Hwang and H.F. Yen et al., 2012. Indiosides G-K: Steroidal Glycosides with Cytotoxic and anti-inflammatory activities from Solanum violaceum. J. Natural Prod., 75: 636-643.
    CrossRef  |  Direct Link  |  
  117. Ting, C.W., T.L. Hwang, I.S. Chen, M.H. Yen and J.J. Chen, 2012. A new benzoylphloroglucinol derivative with an adamantyl skeleton and other constituents from Garcinia multiflora: Effects on neutrophil pro‐inflammatory responses. Chem. Biodiversity, 9: 99-105.
    CrossRef  |  Direct Link  |  
  118. Su, Y.D., T.L. Hwang, N.C. Lin, Y.H. Chen, Y.C. Wu, J.H. Sheu and P.J. Sung, 2012. Briarenolides H and I: New 8-hydroxybriarane diterpenoids from a formosan octocoral Briareum sp. (Briareidae). Bull. Chem. Soc. Jpn., 85: 1031-1036.
    CrossRef  |  Direct Link  |  
  119. Shen, D.Y., C.H. Chao, H.H. Chan, G.J. Huang and T.L. Hwang et al., 2012. Bioactive constituents of Clausena lansium and a method for discrimination of aldose enantiomers. Phytochemistry, 82: 110-117.
    CrossRef  |  Direct Link  |  
  120. New flavan and benzil isolated from Fissistigma latifolium. 2012. New flavan and benzil isolated from Fissistigma latifolium. Chem. Pharmaceut. Bull., 60: 280-282.
    CrossRef  |  Direct Link  |  
  121. Liu, Y.W., Y.B. Cheng, C.C. Liaw, C.H. Chen and J.H. Guh et al., 2012. Bioactive diterpenes from Callicarpa longissima. J. Natural Prod., 75: 689-693.
    CrossRef  |  Direct Link  |  
  122. Liu, F.C., T.L. Hwang, F.W. Liu and H.P. Yu, 2012. Tropisetron attenuates cardiac injury in a rat trauma-hemorrhage model. Shock, 38: 76-81.
    CrossRef  |  Direct Link  |  
  123. Liu, F.C., H.P. Yu, T.L. Hwang and Y.F. Tsai, 2012. Protective effect of tropisetron on rodent hepatic injury after trauma-hemorrhagic shock through P38 MAPK-dependent hemeoxygenase-1 expression. PLoS ONE, Vol. 7. 10.1371/journal.pone.0053203.
    CrossRef  |  Direct Link  |  
  124. Lin, C.F., Y.L. Leu, S.A. Al-Suwayeh, M.C. Ku, T.L. Hwang and J.Y. Fang, 2012. Anti-inflammatory activity and percutaneous absorption of quercetin and its polymethoxylated compound and glycosides: The relationships to chemical structures. Eur. J. Pharmaceut. Sci., 47: 857-864.
    CrossRef  |  Direct Link  |  
  125. Lin, C.F., T.L. Hwang, S.Y. Lin and Y.L. Huang, 2012. Bioactive isocoumarins from Cissus pteroclada. J. Chin. Med., 23: 41-49.
    Direct Link  |  
  126. Leu, Y.L., T.L. Hwang, P.C. Kuo, K.P. Liou, B.S. Huang and G.F. Chen, 2012. Constituents from Vigna vexillata and their anti-inflammatory activity. Int. J. Mol. Sci., 13: 9754-9768.
    CrossRef  |  Direct Link  |  
  127. Lee, C.L., T.L. Hwang, C.Y. Peng, C.J. Chen, Y.S. Chang and Y.C. Wu, 2012. Anti-neutrophilic inflammatory secondary metabolites from the traditional Chinese medicine, Tiankuizi. Nat. Prod. Commun., 7: 1623-1626.
    PubMed  |  
  128. Lee, C.H., C.Y. Kao, S.Y. Kao, C.H. Chang and J.H. Su et al., 2012. Terpenoids from the octocorals Menella sp. (plexauridae) and Lobophytum crassum (alcyonacea). Mar. Drugs, 10: 427-438.
    CrossRef  |  Direct Link  |  
  129. Hwang, T.L., M.C. Tang, L.M. Kuo, W.D. Chang, P.J. Chung, Y.W. Chang and Y.C. Fang, 2012. YC-1 potentiates cAMP-induced CREB activation and nitric oxide production in alveolar macrophages. Toxicol. Applied Pharmacol., 260: 193-200.
    CrossRef  |  Direct Link  |  
  130. Hsieh, S.F., T.J. Hsieh, M. El-Shazly, Y.C. Du and C.C. Wu et al., 2012. Chemical constituents from Farfugium japonicum var. formosanum. Natural Prod. Communi., 7: 435-440.
    Direct Link  |  
  131. Hong, P.H., Y.D. Su, N.C. Lin, Y.H. Chen and Y.H. Kuo et al., 2012. Briarenolide E: The first 2-ketobriarane diterpenoid from an octocoral Briareum sp. (Briareidae). Tetrahedron Lett., 53: 1710-1712.
  132. Hong, P.H., Y.D. Su, J.H. Su, Y.H. Chen and T.L. Hwang et al., 2012. Briarenolides F and G, new briarane diterpenoids from a Briareum sp. octocoral. Mar. Drugs, 10: 1156-1168.
    CrossRef  |  Direct Link  |  
  133. Chung, H.M., P.H. Hong, J.H. Su, T.L. Hwang and M.C. Lu et al., 2012. Bioactive compounds from a gorgonian coral Echinomuricea sp. (Plexauridae). Mar. Drugs, 10: 1169-1179.
    CrossRef  |  Direct Link  |  
  134. Chung, H.M., L.C. Hu, W.H. Yen, J.H. Su and M.C. Lu et al., 2012. Echinohalimane A, a bioactive halimane-type diterpenoid from a Formosan Gorgonian Echinomuricea sp. (Plexauridae). Mar. Drugs, 10: 2246-2253.
    CrossRef  |  Direct Link  |  
  135. Chou, T.H., S.K. Chien, T.L. Hwang, D.C. Wei and I.S. Chen et al., 2012. Orthoquinone and naphthalenone derivatives from Berrya ammonilla and their anti-inflammatory activity. Planta Medica, 78: 919-925.
    PubMed  |  Direct Link  |  
  136. Cho, J.Y., T.L. Hwang, T.H. Chang, Y.P. Lim, P.J. Sung, T.H. Lee and J.J. Chen, 2012. New coumarins and anti-inflammatory constituents from Zanthoxylum avicennae. Food Chem., 135: 17-23.
    CrossRef  |  Direct Link  |  
  137. Cheng, C.H., H.M. Chung, T.L. Hwang, M.C. Lu and Z.H. Wen et al., 2012. Echinoclerodane A: A new bioactive clerodane-type diterpenoid from a gorgonian coral Echinomuricea sp. Molecules, 17: 9443-9450.
    CrossRef  |  Direct Link  |  
  138. Chen, Y.H., T.L. Hwang, Y.D. Su, Y.C. Chang and Y.H. Chen et al., 2012. New 6-hydroxyeunicellins from a soft coral Cladiella sp. Chem. Pharmaceut. Bull., 60: 160-163.
    CrossRef  |  Direct Link  |  
  139. Chen, Y.H., J. Kuo, J.H. Su, T.L. Hwang and Y.H. Chen et al., 2012. Pseudoalteromone B: a novel 15C compound from a marine bacterium Pseudoalteromonas sp. CGH2XX. Mar. Drugs, 10: 1566-1571.
    CrossRef  |  Direct Link  |  
  140. Chen, Y.H., C.Y. Tai, T.L. Hwang and P.J. Sung, 2012. Cladieunicellin H, a new hemiketal eunicellin-based diterpenoid from the octocoral Cladiella sp. Natural Prod. Communi., 7: 481-484.
    Direct Link  |  
  141. Chang, J.Y., C.C. Liaw, A.E. Fazary, T.L. Hwang and Y.C. Shen, 2012. New briarane diterpenoids from the gorgonian coral Junceella juncea. Mar. Drugs, 10: 1321-1330.
    CrossRef  |  Direct Link  |  
  142. Chang, J.Y., A.E. Fazary, Y.C. Lin, T.L. Hwang and Y.C. Shen, 2012. New verticillane diterpenoids from Cespitularia taeniata. Chem. Biodivers., 9: 654-661.
    CrossRef  |  Direct Link  |  
  143. 5. Chen, Y.H., M.C. Lu, Y.C. Chang, T.L. Hwang and W.H. Wang et al., 2012. Pseudoalteromone A: A novel bioactive ubiquinone from a marine bacterium Pseudoalteromonas sp. CGH2XX (Pseudoalteromonadaceae). Tetrahedron Lett., 53: 1675-1677.
    CrossRef  |  Direct Link  |  
  144. Yu, H.P., T.L. Hwang, P.W. Hsieh and Y.T. Lau, 2011. Role of estrogen receptor-dependent upregulation of P38 MAPK/heme oxygenase 1 in resveratrol-mediated attenuation of intestinal injury after trauma-hemorrhage. Shock, 35: 517-523.
    CrossRef  |  Direct Link  |  
  145. Yu, H.P., P.W. Hsieh, Y.J. Chang, P.J. Chung, L.M. Kuo and T.L. Hwang, 2011. 2-(2-Fluorobenzamido)benzoate ethyl ester (EFB-1) inhibits superoxide production by human neutrophils and attenuates hemorrhagic shock-induced organ dysfunction in rats. Free Radic. Biol. Med., 50: 1737-1748.
    CrossRef  |  Direct Link  |  
  146. Yang, M.L., P.C. Kuo, T.L. Hwang, W.F. Chiou and K. Qian et al., 2011. Synthesis, in vitro anti-inflammatory and cytotoxic evaluation, and mechanism of action studies of 1-benzoyl-β-carboline and 1-benzoyl-3-carboxy-β-carboline derivatives. Bioorg. Med. Chem., 19: 1674-1682.
    CrossRef  |  Direct Link  |  
  147. Yang, M.L., P.C. Kuo, T.L. Hwang and T.S. Wu, 2011. Anti-inflammatory principles from Cordyceps sinensis. J. Nat. Prod., 74: 1996-2000.
    CrossRef  |  Direct Link  |  
  148. Wu, S.F., T.L. Hwang, S.L. Chen, C.C. Wu and E. Ohkoshi et al., 2011. Bioactive components from the heartwood of Pterocarpus santalinus. Bioorg. Med. Chem. Lett., 21: 5630-5632.
    CrossRef  |  Direct Link  |  
  149. Wu, S.F., F.R. Chang, S.Y. Wang, T.L. Hwang and C.L. Lee et al., 2011. Anti-inflammatory and cytotoxic neoflavonoids and benzofurans from Pterocarpus santalinus. J. Nat. Prod., 74: 989-996.
    CrossRef  |  Direct Link  |  
  150. Tai, C.Y., Y.H. Chen, T.L. Hwang, L.S. Fang and W.H. Wang et al., 2011. Cladielloides C and D: Novel eunicellin-based diterpenoids from an Indonesian octocoral Cladiella sp. Bull. Chem. Soc. Jpn., 84: 531-536.
  151. Shen, J.J., M.S. Chiang, M.L. Kuo, Y.L. Leu, T.L. Hwang, C.J. Liou and W.C. Huang, 2011. Partially purified extract and viscolin from Viscum coloratum attenuate airway inflammation and eosinophil infiltration in ovalbumin-sensitized mice. J. Ethnopharmacol., 135: 646-653.
    CrossRef  |  Direct Link  |  
  152. Reddy, M.V.B., T.L. Hwang, Y.L. Leu, W.F. Chiou and T.S. Wu, 2011. Inhibitory effects of Mannich bases of heterocyclic chalcones on NO production by activated RAW 264.7 macrophages and superoxide anion generation and elastase release by activated human neutrophils. Bioorg. Med. Chem., 19: 2751-2756.
    CrossRef  |  Direct Link  |  
  153. Reddy, M.V., Y.C. Shen, J.S. Yang, T.L. Hwang and K.F. Bastow et al., 2011. New bichalcone analogs as NF-κB inhibitors and as cytotoxic agents inducing Fas/CD95-dependent apoptosis. Bioorg. Med. Chem., 19: 1895-1906.
    PubMed  |  
  154. Ong, E.T., T.L. Hwang, Y.L. Huang, C.F. Lin and W.B. Wu, 2011. Vitisin B, a resveratrol tetramer, inhibits migration through inhibition of PDGF signaling and enhancement of cell adhesiveness in cultured vascular smooth muscle cells. Toxicol. Applied Pharmacol., 256: 198-208.
    CrossRef  |  Direct Link  |  
  155. Liu, F.C., T.L. Hwang, Y.T. Lau and H.P. Yu, 2011. Mechanism of salutary effects of astringinin on rodent hepatic injury following trauma-hemorrhage: Akt-dependent hemeoxygenase-1 signaling pathways. PLoS ONE, Vol. 6. 10.1371/journal.pone.0025907.
    CrossRef  |  Direct Link  |  
  156. Liaw, C.C., Y.H. Kuo, Y.S. Lin, T.L. Hwang and Y.C. Shen, 2011. Frajunolides L-O, four new 8-hydroxybriarane diterpenoids from the Gorgonian Junceella fragilis. Mar. Drugs, 9: 1477-1486.
    CrossRef  |  Direct Link  |  
  157. Liang, C.J., S.H. Wang, Y.H. Chen, S.S. Chang and T.L. Hwang et al., 2011. Viscolin reduces VCAM-1 expression in TNF-α-treated endothelial cells via the JNK/NF-κB and ROS pathway. Free Radic. Biol. Med., 51: 1337-1346.
    CrossRef  |  Direct Link  |  
  158. Lee, C.L., C.H. Huang, H.C. Wang, D.W. Chuang and M.J. Wu et al., 2011. First total synthesis of antrocamphin A and its analogs as anti-inflammatory and anti-platelet aggregation agents. Org. Biomol. Chem., 9: 70-73.
    CrossRef  |  Direct Link  |  
  159. Kuo, P.C., T.L. Hwang, Y.T. Lin, Y.C. Kuo and Y.L. Leu, 2011. Chemical constituents from Lobelia chinensis and their anti-virus and anti-inflammatory bioactivities. Arch. Pharmacal Res., 34: 715-722.
    CrossRef  |  Direct Link  |  
  160. Kao, S.Y., Y.C. Chang, J.H. Su, M.C. Lu and Y.H. Chen et al., 2011. (-)-hydroxylindestrenolide, a new sesquiterpenoid from a gorgonian coral Menella sp. (Plexauridae). Chem. Pharmaceut. Bull., 59: 1048-1050.
    CrossRef  |  Direct Link  |  
  161. Kao, S.Y., J.H. Su, T.L. Hwang, J.H. Sheu, Z.H. Wen, Y.C. Wu and P.J. Sung, 2011. Menelloides C and D, new sesquiterpenoids from the Gorgonian coral Menella sp. Mar. Drugs, 9: 1534-1542.
    CrossRef  |  Direct Link  |  
  162. Kao, S.Y., J.H. Su, T.L. Hwang, J.H. Sheu and Y.D. Su et al., 2011. Discovery of novel sesquiterpenoids from a gorgonian Menella sp. Tetrahedron, 67: 7311-7315.
    CrossRef  |  Direct Link  |  
  163. Kao, C.Y., J.H. Su, M.C. Lu, T.L. Hwang and W.H. Wang et al., 2011. Lobocrassins A-E: New cembrane-type diterpenoids from the soft coral Lobophytum crassum. Mar. Drugs, 9: 1319-1331.
    CrossRef  |  Direct Link  |  
  164. Hwang, T.L., C.L. Fang, S.A. Al-Suwayeh, L.J. Yang and J.Y. Fang, 2011. Activated human neutrophil response to perfluorocarbon nanobubbles: Oxygen-dependent and -independent cytotoxic responses. Toxicol. Lett., 203: 172-180.
    CrossRef  |  Direct Link  |  
  165. Hua, M.Y., H.W. Yang, H.L. Liu, R.Y. Tsai and S.T. Pang et al., 2011. Superhigh-magnetization nanocarrier as a doxorubicin delivery platform for magnetic targeting therapy. Biomaterials, 32: 8999-9010.
    CrossRef  |  Direct Link  |  
  166. Hsu, J.L., S.L. Pan, Y.F. Ho, T.L. Hwang, F.L. Kung and J.H. Guh, 2011. Costunolide induces apoptosis through nuclear Calcium2+ overload and DNA damage response in human prostate cancer. J. Urol., 185: 1967-1974.
    CrossRef  |  Direct Link  |  
  167. Chung, Y.M., Y.H. Lan, T.L. Hwang and Y.L. Leu, 2011. Anti-inflammatory and antioxidant components from Hygroryza aristata. Molecules, 16: 1917-1927.
    CrossRef  |  Direct Link  |  
  168. Chung, Y.M., F.R. Chang, T.F. Tseng, T.L. Hwang and L.C. Chen et al., 2011. A novel alkaloid, aristopyridinone A and anti-inflammatory phenanthrenes isolated from Aristolochia manshuriensis. Bioorg. Med. Chem. Lett., 21: 1792-1794.
    CrossRef  |  Direct Link  |  
  169. Chung, H.M., T.L. Hwang, Y.H. Chen, J.H. Su and M.C. Lu et al., 2011. Rumphellclovane B, a novel clovane analogue from the gorgonian coral Rumphella antipathies. Bull. Chem. Soc. Jpn., 84: 119-121.
    CrossRef  |  Direct Link  |  
  170. Cho, J.Y., T.H. Lee, T.L. Hwang, S.Z. Yang and I.S. Chen et al., 2011. A new ferulic acid ester, a new ellagic acid derivative and other constituents from Pachycentria formosana: Effects on neutrophil pro-inflammatory responses. Chem. Biodivers., 8: 1709-1716.
    CrossRef  |  Direct Link  |  
  171. Chin, C.H., T.L. Hwang, C.C. Chang, C.L. Liu and J.J. Lee et al., 2011. YC-1 inhibits lipid droplet accumulation and induces lipolysis in lipid-laden RAW264.7 macrophages. J. Food Drug Anal., 19: 437-444.
  172. Cheng, Y.D., T.L. Hwang, H.H. Wang, T.L. Pan and C.C. Wu et al., 2011. Anthranilic acid-based inhibitors of phosphodiesterase: Design, synthesis and bioactive evaluation. Org. Biomol. Chem., 9: 7113-7125.
    CrossRef  |  Direct Link  |  
  173. Chen, Y.H., C.Y. Tai, Y.H. Kuo, C.Y. Kao and J.J. Li et al., 2011. Cladieunicellins AE, new eunicellins from an Indonesian soft coral Cladiella sp. Chem. Pharmaceut. Bull., 59: 353-358.
    CrossRef  |  Direct Link  |  
  174. Chen, Y.H., C.Y. Tai, Y.D. Su, Y.C. Chang and M.C. Lu et al., 2011. Discovery of new eunicellins from an Indonesian octocoral Cladiella sp. Mar. Drugs, 9: 934-943.
    CrossRef  |  Direct Link  |  
  175. Chen, T.Y., T.L. Hwang, C.Y. Lin, T.N. Lin, H.Y. Lai, W.P. Tsai and H.H. Lin, 2011. EMR2 receptor ligation modulates cytokine secretion profiles and cell survival of lipopolysaccharide-treated neutrophils. Chang Gung Med. J., 34: 468-477.
    Direct Link  |  
  176. Chen, J.J., Y.H. Lin, S.H. Day, T.L. Hwang and I.S. Chen, 2011. New benzenoids and anti-inflammatory constituents from Zanthoxylum nitidum. Food Chem., 125: 282-287.
    CrossRef  |  Direct Link  |  
  177. Chen, J.J., Y.C. Tsai, T.L. Hwang and T.C. Wang, 2011. Thymol, benzofuranoid and phenylpropanoid derivatives: Anti-inflammatory constituents from Eupatorium cannabinum. J. Nat. Prod., 74: 1021-1027.
    CrossRef  |  Direct Link  |  
  178. Chan, H.H., T.L. Hwang, M.V.B. Reddy, D.T. Li and K. Qian et al., 2011. Bioactive constituents from the roots of Panax japonicus var. major and development of a LC-MS/MS method for distinguishing between natural and artifactual compounds. J. Nat. Prod., 74: 796-802.
    CrossRef  |  Direct Link  |  
  179. Chan, H.H., T.L. Hwang, C.R. Su, M.V.B. Reddy and T.S. Wu, 2011. Anti-inflammatory, anticholinesterase and antioxidative constituents from the roots and the leaves of Salvia nipponica Miq. var. formosana. Phytomedicine, 18: 148-150.
    CrossRef  |  Direct Link  |  
  180. Yu, H.P., T.L. Hwang, T.L. Hwang, C.H. Yen and Y.T. Lau, 2010. Resveratrol prevents endothelial dysfunction and aortic superoxide production after trauma hemorrhage through estrogen receptor-dependent hemeoxygenase-1 pathway. Crit. Care Med., 38: 1147-1154.
    PubMed  |  
  181. Yu, H.P., S.C. Yang, Y.T. Lau and T.L. Hwang, 2010. Role of Akt-dependent up-regulation of hemeoxygenase-1 in resveratrol-mediated attenuation of hepatic injury after trauma-hemorrhage. Surgery, 148: 103-109.
    CrossRef  |  
  182. Yen, C.T., K. Nakagawa-Goto, T.L. Hwang, P.C. Wu and S.L. Morris-Natschke et al., 2010. Antitumor agents. 271: Total synthesis and evaluation of brazilein and analogs as anti-inflammatory and cytotoxic agents. Bioorg. Med. Chem. Lett., 20: 1037-1039.
  183. Wu, S.J., H.H. Chan, T.L. Hwang, K. Qian, S. Morris-Natschke, K.H. Lee and T.S. Wu, 2010. Salviatalin A and salvitrijudin A, two diterpenes with novel skeletons from roots of Salvia digitaloides and anti-inflammatory evaluation. Tetrahedron Lett., 51: 4287-4290.
    CrossRef  |  Direct Link  |  
  184. Wang, T.Y., J.B. Wu, T.L. Hwang, Y.H. Kuo and J.J. Chen, 2010. A new quinolone and other constituents from the fruits of Tetradium ruticarpum: Effects on neutrophil pro‐inflammatory responses. Chem. Biodivers., 7: 1828-1834.
    CrossRef  |  Direct Link  |  
  185. Wang, S.H., Y.C. Chang, M.Y. Chiang, Y.H. Chen, T.L. Hwang, C.F. Weng and P.J. Sung, 2010. Chlorinated briarane diterpenoids from the sea whip gorgonian corals Junceella fragilis and Ellisella robusta (Ellisellidae). Chem. Pharmaceut. Bull., 58: 928-933.
    CrossRef  |  Direct Link  |  
  186. Sung, P.J., G.Y. Li, Y.D. Su, M.R. Lin and Y.C. Chang et al., 2010. Excavatoids O and P, new 12-hydroxybriaranes from the octocoral Briareum excavatum. Mar. Drugs, 8: 2639-2646.
    CrossRef  |  Direct Link  |  
  187. Sung, P.J., B.Y. Chen, M.Y. Chiang, C.H. Hou and Y.D. Su et al., 2010. Excavatoids GK, new 8, 17-epoxybriaranes from the cultured octocoral Briareum excavatum (Briareidae). Bull. Chem. Soc. Jpn., 83: 539-545.
    CrossRef  |  Direct Link  |  
  188. Su, J.H., B.Y. Chen, T.L. Hwang, Y.H. Chen and I.C. Huang et al., 2010. Excavatoids L-N, new 12-hydroxybriaranes from the cultured octocoral Briareum excavatum (Briareidae). Chem. Pharm. Bull. (Tokyo), 58: 662-665.
    PubMed  |  
  189. Liu, C.Y., T.L. Hwang, M.R. Lin, Y.H. Chen and Y.C. Chang et al., 2010. Carijoside A, a bioactive sterol glycoside from an octocoral Carijoa sp. (Clavulariidae). Mar. Drugs, 8: 2014-2020.
    CrossRef  |  
  190. Lee, C.L., Y.C. Liao, T.L. Hwang, C.C. Wu, F.R. Chang and Y.C. Wu, 2010. Ixorapeptide I and ixorapeptide II, bioactive peptides isolated from Ixora coccinea. Bioorg. Med. Chem. Lett., 20: 7354-7357.
    CrossRef  |  Direct Link  |  
  191. Hwang, T.L., C.C. Wang, Y.H. Kuo, H.C. Huang, Y.C. Wu, L.M. Kuo and Y.H. Wu, 2010. The hederagenin saponin SMG-1 is a natural FMLP receptor inhibitor that suppresses human neutrophil activation. Biochem. Pharmacol., 80: 1190-2000.
    CrossRef  |  
  192. Huang, Y.C., T.L. Hwang, Y.L. Yang, S.H. Wu and M.H. Hsu et al., 2010. Acetogenin and prenylated flavonoids from Helminthostachys zeylanica with inhibitory activity on superoxide generation and elastase release by Neutrophils. Planta. Med., 76: 447-453.
    CrossRef  |  
  193. Hsieh, P.W., H.P. Yu, Y.J. Chang and T.L. Hwang, 2010. Synthesis and evaluation of benzoxazinone derivatives on activity of human neutrophil elastase and on hemorrhagic shock-induced lung injury in rats. Eur. J. Med. Chem., 45: 3111-3115.
    CrossRef  |  
  194. Chung, H.M., Y.H. Chen, T.L. Hwang, L.F. Chuang, W.H. Wang and P.J. Sung, 2010. Rumphellclovane A, a novel clovane-related sesquiterpenoid from the gorgonian coral Rumphella antipathies. Tetrahedron Lett., 51: 2734-2736.
    CrossRef  |  Direct Link  |  
  195. Cheng, Y.B., T.C. Liao, Y.W. Lo, Y.C. Chen and Y.C. Kuo et al., 2010. Nortriterpene lactones from the fruits of Schisandra arisanensis. J. Natural Prod., 73: 1228-1233.
    CrossRef  |  Direct Link  |  
  196. Chen, Y.H., C.Y. Tai, T.L. Hwang, C.F. Weng and J.J. Li et al., 2010. Cladielloides A and B: New eunicellin-type diterpenoids from an Indonesian octocoral Cladiella sp. Mar. Drugs, 8: 2936-2945.
    CrossRef  |  Direct Link  |  
  197. Chen, J.J., C.S. Tsai, T.L. Hwang, P.C. Shieh, J.F. Chen and P.J. Sung, 2010. Sesquiterpenes from the rhizome of Curcuma longa with inhibitory activity on superoxide generation and elastase release by neutrophils. Food Chem., 119: 974-980.
    Direct Link  |  
  198. Chang, Y.C., T.L. Hwang, S.K. Huang, L.W. Huang, M.R. Lin and P.J. Sung, 2010. Fragilide G, a new briarane-type diterpenoid from the gorgonian coral Ellisella robusta. Heterocycles, 81: 991-996.
  199. Chang, Y.C., I.C. Huang, M.Y.N. Chiang, T.L. Hwang and T.H. Kung et al., 2010. Briaviodiol A, a new cembranoid from a soft coral Briareum violacea. Chem. Pharmaceut. Bull., 52: 1666-1668.
    CrossRef  |  Direct Link  |  
  200. Yu, H.P., P.W. Hsieh, Y.J. Chang, P.J. Chung, L.M. Kuo and T.L. Hwang, 2009. DSM-RX78, a new phosphodiesterase inhibitor, suppresses superoxide anion production in activated human neutrophils and attenuates hemorrhagic shock-induced lung injury in rats. Biochem. Pharmacol., 78: 983-992.
    CrossRef  |  
  201. Yen, C.T., T.L. Hwang, Y.C. Wu and P.W. Hsieh, 2009. Design and synthesis of new N-(fluorenyl-9-methoxycarbonyl) (Fmoc)-dipeptides as anti-inflammatory agents. Eur. J. Med. Chem., 44: 1933-1940.
    PubMed  |  
  202. Yen, C.T., P.W. Hsieh, T.L. Hwang, Y.H. Lan, F.R. Chang and Y.C. Wu, 2009. Flavonol glycosides from muehlenbeckia platyclada and their anti-inflammatory activity. Chem. Pharm. Bull. (Tokyo), 57: 280-282.
    CrossRef  |  
  203. Sung, P.J., Y.D. Su, T.L. Hwang, L.F. Chuang and H.M. Chung et al., 2009. Rumphellolide I, a novel caryophyllane-related tetrahydropyran norsesquiterpenoid from gorgonian coral Rumphella antipathies. Chem. Lett., 38: 282-283.
    CrossRef  |  
  204. Sung, P.J., M.R. Lin, M.Y. Chiang and T.L. Hwang, 2009. Briaexcavatins VZ, discovery of new briaranes from a cultured octocoral Briareum excavatum. Bull. Chem. Soc. Japan, 82: 987-996.
    CrossRef  |  
  205. Sung, P.J., B.Y. Chen, M.R. Lin, T.L. Hwang, W.H. Wang, J.H. Sheu and Y.C. Wu, 2009. Excavatoids E and F: discovery of two new briaranes from the cultured octocoral Briareum excavatum. Mar. Drugs, 7: 472-482.
    CrossRef  |  
  206. Lin, Y.K., Y.L. Leu, T.H. Huang, Y.H. Wu, P.J. Chung, J.H.S. Pang and Y.L. Hwang, 2009. Anti-inflammatory effects of the extract of indigo naturalis in human neutrophils. J. Ethnopharmacol., 125: 51-58.
    CrossRef  |  
  207. Lin, Y.C., M.H. Abd El-Razek, T.L. Hwang, M.Y. Chiang, Y.H. Kuo, C.F. Dai and Y.C. Shen, 2009. Asterolaurins A-F, xenicane diterpenoids from the Taiwanese soft coral Asterospicularia laurae. J. Nat. Prod., 72: 1911-1916.
    PubMed  |  
  208. Lin, A.S., C.R. Lin, Y.C. Du, T. Lubken and M.Y. Chiang et al., 2009. Acasiane A and B and Farnesirane A and B, Diterpene derivatives from the roots of Acacia farnesiana. Planta Med., 75: 256-261.
    PubMed  |  
  209. Hwang, T.L., Y.K. Lin, C.H. Chi, T.H. Huang and J.Y. Fang, 2009. Development and evaluation of perfluorocarbon nanobubbles for apomorphine delivery. J. Pharm. Sci., 98: 3735-3747.
    PubMed  |  
  210. Hwang, T.L., Y.D. Su, W.P. Hu, L.F. Chuang and P.J. Sung, 2009. Rumphellolide H, a new natural caryophyllane from the Gorgonian Rumphella antipathies. Heterocycles, 78: 1563-1567.
    CrossRef  |  
  211. Hwang, T.L., Y.C. Su, H.L. Chang, Y.L. Leu, P.J. Chung, L.M. Kuo and Y.J. Chang, 2009. Suppression of superoxide anion and elastase release by C18 unsaturated fatty acids in human neutrophils. J. Lipid Res., 50: 1395-1408.
    PubMed  |  
  212. Hwang, T.L., G.L. Li, Y.H. Lan, Y.C. Chia, P.W. Hsieh, Y.H. Wu and Y.C. Wu, 2009. Potent inhibition of superoxide anion production in activated human neutrophils by isopedicin, a bioactive component of the Chinese medicinal herb Fissistigma oldhamii. Free Radic. Biol. Med., 46: 520-528.
    PubMed  |  
  213. Hwang, T.L., C.L. Fang, C.H. Chen and J.Y. Fang, 2009. Permeation enhancer-containing water-in-oil nanoemulsions as carriers for intravesical cisplatin delivery. Pharm. Res., 26: 2314-2323.
    PubMed  |  
  214. Huang, Y.C., T.L. Hwang, C.S. Chang, Y.L. Yang and C.N. Shen et al., 2009. Anti-inflammatory Flavonoids from the Rhizomes of Helminthostachys zeylanica. J. Nat. Prod., 72: 1273-1278.
    CrossRef  |  
  215. Hsieh, P.W., L.C. Hsu, C.H. Lai, C.C. Wu, T.L. Hwang, Y.K. Lin and Y.C. Wu, 2009. Evaluation of the bioactivities of extracts of endophytes isolated from Taiwanese herbal plants. World J. Microbiol. Biotechnol., 25: 1461-1469.
    CrossRef  |  Direct Link  |  
  216. Fang, J.Y., C.F. Hung, S.C. Hua and T.L. Hwang, 2009. Acoustically active perfluorocarbon nanoemulsions as drug delivery carriers for camptothecin: Drug release and cytotoxicity against cancer cells. Ultrasonics, 49: 39-46.
    PubMed  |  
  217. Chung, H.M., T.L. Hwang, W.H. Wang, L.S. Fang and P.J. Sung, 2009. Curcuphenol derivatives from the gorgonian Echinomuricea sp. Heterocycles, 78: 2595-2600.
  218. Chen, J.J., C.Y. Chung, T.L. Hwang and J.F. Chen, 2009. Amides and benzenoids from Zanthoxylum ailanthoides with inhibitory activity on superoxide generation and elastase release by neutrophils. J. Nat. Prod., 72: 107-111.
    PubMed  |  
  219. Chen, J.J., C.W. Ting, T.L. Hwang and I.S. Chen, 2009. Benzophenone Derivatives from the Fruits of Garcinia multiflora and their anti-inflammatory activity. J. Nat. Prod., 72: 253-258.
    CrossRef  |  
  220. Wu, K.P., J.Y. Ke, C.Y. Chung, C.L. Chen and T.L. Hwang et al., 2008. Relationship between unstimulated salivary flow rate and saliva composition of healthy children in Taiwan. Chang Gung Med. J., 31: 281-286.
  221. Sung, P.J., M.R. Lin, Y.D. Su, M.Y. Chiang and W.P. Hu et al., 2008. New briaranes from the octocorals Briareum excavatum (Briareidae) and Junceella fragilis (Ellisellidae). Tetrahedron, 64: 2596-2604.
    CrossRef  |  
  222. Sung, P.J., M.R. Lin, T.L. Hwang, T.Y. Fan and W.H. Wang et al., 2008. Briaexcavatins M-P, four new briarane-related diterpenoids from cultured octocoral Briareum excavatum (Briareidae). Chem. Pharm. Bull. (Tokyo)., 56: 930-935.
    PubMed  |  
  223. Sung, P.J., J.J. Chen, J.J. Li, L.S. Fang and W.H. Wang et al., 2008. Rumphellatin D, a Novel Caryophyllane from Gorgonian Coral Rumphella antipathies. Chem. Lett., 37: 1244-1245.
    CrossRef  |  
  224. Sung, P.J., C.H. Pai, Y.D. Su, T.L. Hwang, F.W. Kuo, T.Y. Fan and J.J. Li, 2008. New 8-hydroxybriarane diterpenoids from the gorgonians Junceella juncea and Junceella fragilis (Ellisellidae). Tetrahedron, 64: 4224-4232.
    CrossRef  |  
  225. Sung, P.J., C.H. Pai, T.L. Hwang, T.Y. Fan and J.H. Su et al., 2008. Junceols D-H, new polyoxygenated briaranes from sea whip gorgonian coral Junceella juncea (Ellisellidae). Chem. Pharm. Bull. (Tokyo)., 56: 1276-1281.
    PubMed  |  
  226. Liaw, C.C., Y.H. Kuo, T.L. Hwang and Y.C. Shen, 2008. Eupatozansins A-C, sesquiterpene lactones from Eupatorium chinense var. tozanense. Helvetica Chim. Acta, 91: 2115-2121.
    CrossRef  |  Direct Link  |  
  227. Liaw, C.C., Y.C. Shen, Y.S. Lin, T.L. Hwang, Y.H. Kuo and A.T. Khalil, 2008. Frajunolides E-K, briarane diterpenes from Junceella fragilis. J. Nat. Prod., 71: 1551-1556.
    PubMed  |  
  228. Leu, Y.L., T.L. Hwang, J.W. Hu and J.Y. Fang, 2008. Anthraquinones from Polygonum cuspidatum as tyrosinase inhibitors for dermal use. Phytother. Res., 22: 552-556.
    PubMed  |  
  229. Lee, C.W., C.C. Lin, S.F. Luo, H.C. Lee and C.M. Yang et al., 2008. TNFα enhances neutrophil adhesiveness: Induction of VCAM-1 via activation of Akt and CaM kinase II and modification of HAT and HDAC4 in human tracheal smooth muscle cells. Mol. Pharmacol., 73: 1454-1464.
    Direct Link  |  
  230. Lee, C.L., P.C. Huang, P.W. Hsieh, T.L. Hwang, Y.Y. Hou, F.R. Chang and Y.C. Wu, 2008. (-)-Xanthienopyran, a new inhibitor of superoxide anion generation by activated neutrophils and further constituents of the seeds of Xanthium strumarium. Planta Med., 74: 1276-1279.
    PubMed  |  
  231. Hwang, T.L., S.K. Zhuo and Y.L. Pan, 2008. YC-1 attenuates homotypic human neutrophil aggregation through inhibition of phosphodiesterase activity. Eur. J. Pharmacol., 579: 395-402.
    CrossRef  |  
  232. Hwang, T.L., M.R. Lin, W.T. Tsai, H.C. Yeh, W.P. Hu, J.H. Sheu and P.J. Sung, 2008. New polyoxygenated briaranes from octocorals Briareum excavatum and Ellisella robusta. Bull. Chem. Soc. Jpn., 81: 1638-1646.
    CrossRef  |  
  233. Chou, T.H., I.S. Chen, T.L. Hwang, T.C. Wang and T.H. Lee et al., 2008. Phthalides from Pittosporum illicioides var. illicioides with inhibitory activity on superoxide generation and elastase release by neutrophils. J. Nat. Prod., 71: 1692-1695.
    CrossRef  |  
  234. Chen, J.J., Y.T. Luo, T.L. Hwang, P.J. Sung, T.C. Wang and I.S. Chen, 2008. A new indole alkaloid and anti-inflammatory constituents from Strychnos cathayensis. Chem. Biodivers., 5: 1345-1352.
    PubMed  |  
  235. Chen, J.J., T.Y. Wang and T.L. Hwang, 2008. Neolignans, a coumarinolignan, lignan derivatives and a chromene: Anti-inflammatory constituents from Zanthoxylum avicennae. J. Nat. Prod., 71: 212-217.
    CrossRef  |  
  236. Chen, J.J., J.Y. Cho, T.L. Hwang and I.S. Chen, 2008. Benzoic acid derivatives, acetophenones and anti-inflammatory constituents from Melicope semecarpifolia. J. Nat. Prod., 71: 71-75.
    PubMed  |  
  237. Chang, H.L., F.R. Chang, J.S. Chen, H.P. Wang and Y.H. Wu et al., 2008. Inhibitory effects of 16-hydroxycleroda-3, 13 (14) E-dien-15-oic acid on superoxide anion and elastase release in human neutrophils through multiple mechanisms. Eur. J. Pharmacol., 586: 332-339.
    CrossRef  |  
  238. Sung, P.J., Y.P. Chen, Y.M. Su, T.L. Hwang, W.P. Hu, T.Y. Fan and W.H. Wang, 2007. Fragilide B: A Novel Briarane-Type Diterpenoid with a S-cis Diene Moiety. Bull. Chem. Soc. Jpn., 80: 1205-1207.
    CrossRef  |  
  239. Sung, P.J., M.R. Lin, J.J. Chen, S.F. Lin, Y.C. Wu, T.L. Hwang and L.S. Fang, 2007. Hydroperoxysterols from the tunicate Eudistoma sp. Chem. Pharm. Bull. (Tokyo), 55: 666-668.
    CrossRef  |  
  240. Shen, Y.C., Y.H. Chen, T.L. Hwang, J.H. Guh and A.T. Khalil, 2007. Four new briarane diterpenoids from the gorgonian coral Junceella fragilis. Helvetica Chimica Acta., 90: 1391-1398.
    CrossRef  |  
  241. Shen, Y.C., S.Y. Cheng, Y.H. Kuo, T.L. Hwang, M.Y. Chiang and A.T. Khalil, 2007. Chemical transformation and biological activities of ambrein, a major product of ambergris from Physeter macrocephalus (Sperm Whale). J. Nat. Prod., 70: 147-153.
    CrossRef  |  Direct Link  |  
  242. Hwang, T.L., W.R. Lee, S.C. Hua and J.Y. Fang, 2007. Cisplatin encapsulated in phosphatidylethanolamine liposomes enhances the in vitro cytotoxicity and in vivo intratumor drug accumulation against melanomas. J. Dermatol. Sci., 46: 11-20.
    CrossRef  |  
  243. Hsieh, P.W., T.L. Hwang, C.C. Wu, S.Z. Chiang, C.I. Wu and Y.C. Wu, 2007. The evaluation and structure-activity relationships of 2-benzoylaminobenzoic esters and their analogues as anti-inflammatory and anti-platelet aggregation agents. Bioorg. Med. Chem. Lett., 17: 1812-1817.
    CrossRef  |  
  244. Chen, Y.P., S.L. Wu, J.H. Su, M.R. Lin and P.J. Sung, 2007. Briaexcavatins G and H, two new briaranes from the octocoral Briareum excavatum. Bull. Chem. Soc. Jpn., 79: 1900-1905.
    CrossRef  |  
  245. Sung, P.J., Y.P. Chen, T.L. Hwang, J.J. Li and J.H. Sheu et al., 2006. Briaexcavatins C-F, four new briarane-related diterpenoids from the Formosan octocoral Briareum excavatum (Briareidae). Tetrahedron, 62: 5686-5691.
  246. Sheu, J.H., Y.P. Chen, T.L. Hwang, M.Y. Chiang, L.S. Fang and P.J. Sung, 2006. Junceellolides JL, 11, 20-epoxybriaranes from the gorgonian coral Junceella fragilis. J. Nat. Prod., 69: 269-273.
    CrossRef  |  Direct Link  |  
  247. Leu, Y.L., T.L. Hwang, Y.M. Chung and P.Y. Hong, 2006. The inhibition of superoxide anion generation in human neutrophils by Viscum coloratum. Chem. Pharm. Bull., 54: 1063-1066.
    CrossRef  |  Direct Link  |  
  248. Leu, Y.L., T.L. Hwang, Y.M. Chung and P.Y. Hong, 2006. The inhibition of superoxide anion generation in human neutrophils by Viscum coloratum. Chem. Pharm. Bull. (Tokyo), 54: 1063-1066.
    PubMed  |  
  249. Hwang, T.L., Y.L. Leu, S.H. Kao, M.C. Tang and H.L. Chang, 2006. Viscolin, a new chalcone from Viscum coloratum, inhibits human neutrophil superoxide anion and elastase release via a cAMP-dependent pathway. Free Radical Biol. Med., 41: 1433-1441.
    CrossRef  |  Direct Link  |  
  250. Hwang, T.L., S.H. Yeh, Y.L. Leu, C.Y. Chern and H.C. Hsu, 2006. Inhibition of superoxide anion and elastase release in human neutrophils by 3'-isopropoxychalcone via a cAMP‐dependent pathway. Br. J. Pharmacol., 148: 78-87.
    CrossRef  |  Direct Link  |  
  251. Hsieh, H.L., C.Y. Wu, T.L. Hwang, M.H. Yen, P. Parker and C.M. Yang, 2006. BK-induced cytosolic phospholipase A2 expression via sequential PKC‐δ, p42/p44 MAPK and NF‐κB activation in rat brain astrocytes. J. Cell. Physiol., 206: 246-254.
    CrossRef  |  Direct Link  |  
  252. Fang, J.Y., T.L. Hwang, Y.L. Huang and C.L. Fang, 2006. Enhancement of the transdermal delivery of catechins by liposomes incorporating anionic surfactants and ethanol. Int. J. Pharm., 310: 131-138.
    CrossRef  |  Direct Link  |  
  253. Fang, J.Y., T.L. Hwang and Y.L. Huang, 2006. Liposomes as vehicles for enhancing drug delivery via skin routes. Curr. Nanosci., 2: 55-70.
    Direct Link  |  
  254. Chen, Y.P., S.L. Wu, J.H. Su, M.R. Lin and W.P. Hu et al., 2006. Briaexcavatins G and H, two new briaranes from the octocoral Briareum excavatum. Bull. Chem. Soc. Japan, 79: 1900-1905.
    CrossRef  |  
  255. Chang, F.R., T.L. Hwang, Y.L. Yang, C.E. Li and C.C. Wu et al., 2006. Anti-inflammatory and cytotoxic diterpenes from formosan Polyalthia longifolia var. pendula. Planta Med., 72: 1344-1347.
    PubMed  |  
  256. Yeh, S.H., F.R. Chang, Y.C. Wu, Y.L. Yang, S.K. Zhuo and T.L. Hwang, 2005. An anti-inflammatory ent-kaurane from the stems of Annona squamosa that inhibits various human neutrophil functions. Planta Med., 71: 904-909.
  257. Wang, H.P., T.L. Hwang, O. Lee, Y.J. Tseng, C.Y. Shu and S.J. Lee, 2005. Selective cytotoxicity of azatyrosinamides against ras-transformed NIH 3T3 cells. Bioorganic Med. Chem. Lett., 15: 4272-4274.
    CrossRef  |  Direct Link  |  
  258. Lan, Y.H., Y.C. Chia, F.R. Chang, T.L. Hwang, C.C. Liaw and Y.C. Wu, 2005. Potential Anti‐Inflammatory Activities of Bractelactone and other Compounds Isolated from Fissistigma bracteolatum. Helvetica Chim. Acta, 88: 905-909.
    CrossRef  |  Direct Link  |  
  259. Hwang, T.L., Y.C. Wu, S.H. Yeh and R.Y. Kuo, 2005. Suppression of respiratory burst in human neutrophils by new synthetic pyrrolo-benzylisoquinolines. Biochem. Pharmacol., 69: 65-71.
    CrossRef  |  Direct Link  |  
  260. Hung, C.F., T.L. Hwang, C.C. Chang and J.Y. Fang, 2005. Physicochemical characterization and gene transfection efficiency of lipid emulsions with various co-emulsifiers. Int. J. Pharm., 289: 197-208.
    CrossRef  |  PubMed  |  
  261. Hsieh, P.W., T.L. Hwang, C.C. Wu, F.R. Chang, T.W. Wang and Y.C. Wu, 2005. The evaluation of 2, 8-disubstituted benzoxazinone derivatives as anti-inflammatory and anti-platelet aggregation agents. Bioorganic Med. Chem. Lett., 15: 2786-2789.
    CrossRef  |  Direct Link  |  
  262. Fang, J.Y., C.F. Hung, T.L. Hwang and Y.L. Huang, 2005. Physicochemical characteristics and in vivo deposition of liposome-encapsulated tea catechins by topical and intratumor administrations. J. Drug Targeting, 13: 19-27.
    CrossRef  |  Direct Link  |  
  263. Fang, J.Y., C.F. Hung, T.L. Hwang and W.W. Wong, 2005. Transdermal delivery of tea catechins by electrically assisted methods. Skin Pharmacol. Physiol., 19: 28-37.
    CrossRef  |  Direct Link  |  
  264. Chen, K.S., P.W. Hsieh, T.L. Hwang, F.R. Chang and Y.C. Wu, 2005. Anti-inflammatory furanogermacrane sesquiterpenes from Neolitsea parvigemma. Nat. Prod. Res., 19: 283-286.
    CrossRef  |  Direct Link  |  
  265. Yang, Y.L., F.R. Chang, T.L. Hwang, W.T. Chang and Y.C. Wu, 2004. Inhibitory effects of ent-kauranes from the stems of Annona squamosa on superoxide anion generation by human neutrophils. Planta Med., 70: 256-258.
  266. Leu, Y.L., S.M. Kuo, T.L. Hwang and S.T. Chiu, 2004. The inhibition of superoxide anion generation by neutrophils from Viscum articulactum. Chem. Pharm. Bull., 52: 858-860.
    CrossRef  |  
  267. Hsieh, P.W., F.R. Chang, K.H. Lee, T.L. Hwang, S.M. Chang and Y.C. Wu, 2004. A new anti-HIV alkaloid, drymaritin and a new C-glycoside flavonoid, diandraflavone, from Drymaria diandra. J. Nat. Prod., 67: 1175-1177.
    CrossRef  |  Direct Link  |  
  268. Fang, J.Y., Y.L. Leu, T.L. Hwang and H.C. Cheng, 2004. Essential oils from sweet basil (Ocimum basilicum) as novel enhancers to accelerate transdermal drug delivery. Biol. Pharm. Bull., 27: 1819-1825.
    Direct Link  |  
  269. Wu, C.C., T.L. Hwang, C.H. Liao, S.C. Kuo, F.Y. Lee, C.M. Teng, 2003. The role of PAR4 in thrombin-induced thromboxane production in human platelets. Thromb. Haemost., 90: 299-308.
  270. Hwang, T.L., H.W. Hung, S.H. Kao, C.M. Teng, C.C. Wu and S.J. Cheng, 2003. Soluble guanylyl cyclase activator YC-1 inhibits human neutrophil functions through a cGMP-independent but cAMP-dependent pathway. Mol. Pharmacol., 64: 1419-1427.
    CrossRef  |  Direct Link  |  
  271. Hwang, T.L., C.C. Wu, J.H. Guh and C.M. Teng, 2003. Potentiation of tumor necrosis factor-α expression by YC-1 in alveolar macrophages through a cyclic GMP-independent pathway. Biochem. Pharmacol., 66: 149-156.
    CrossRef  |  
  272. Fang, J.Y., Y.L. Leu, T.L. Hwang, H.C. Cheng and C.F. Hung, 2003. Development of sesquiterpenes from Alpinia oxyphylla as novel skin permeation enhancers. Eur. J. Pharm. Sci., 19: 253-262.
    CrossRef  |  Direct Link  |  
  273. Fang, J.Y., T.L. Hwang, C.L. Fang and H.C. Chiu, 2003. In vitro and in vivo evaluations of the efficacy and safety of skin permeation enhancers using flurbiprofen as a model drug. Int. J. Pharm., 255: 153-166.
    CrossRef  |  Direct Link  |  
  274. Fang, J.Y., T.L. Hwang and Y.L. Leu, 2003. Effect of enhancers and retarders on percutaneous absorption of flurbiprofen from hydrogels. Int. J. Pharm., 250: 313-325.
    CrossRef  |  Direct Link  |  
  275. Chang, F.R., C.C. Wu, T.L. Hwang, R. Patnam and R.Y. Kuo et al., 2003. Effect of active synthetic 2-substituted quinazolinones on anti-platelet aggregation and the inhibition of superoxide anion generation by neutrophils. Arch. Pharm. Res., 26: 511-515.
    CrossRef  |  Direct Link  |  
  276. Yau, K.I. and T.L. Hwang, 2002. The nonadrenergic noncholinergic system can modulate the effect of prokinetic agents on contractile response of isolated guinea-pig trachea segments to electrical field stimulation. J. Formos Med. Assoc., 101: 695-699.
  277. Wu, C.C., T.L. Hwang, C.H. Liao, S.C. Kuo, F.Y. Lee, C.Y. Lee and C.M. Teng, 2002. Selective inhibition of protease-activated receptor 4-dependent platelet activation by YD-3. Thromb. Haemost., 87: 1026-1033.
    Direct Link  |  
  278. Fang, J.Y., T.L. Hwang, Y.B. Huang and Y.H. Tsai, 2002. Transdermal iontophoresis of sodium nonivamide acetate: V. Combined effect of physical enhancement methods. Int. J. Pharm., 235: 95-105.
    CrossRef  |  Direct Link  |  
  279. Huang, Y.C., J.H. Guh, Z.J. Cheng, Y.L. Chang, T.L. Hwang, C.N. Lin and C.M. Teng, 2001. Inhibitory effect of DCDC on lipopolysaccharide-induced nitric oxide synthesis in RAW 264.7 cells. Life Sci., 68: 2435-27447.
    CrossRef  |  Direct Link  |  
  280. Huang, Y.C., J.H. Guh, Z.J. Cheng, Y.L. Chang and T.L. Hwang et al., 2001. Inhibition of the expression of inducible nitric oxide synthase and cyclooxygenase-2 in macrophages by 7HQ derivatives: Involvement of IkappaB-α stabilization. Eur. J. Pharmacol., 418: 133-139.
  281. Cheng, Z.J., C.N. Lin, T.L. Hwang and C.M. Teng, 2001. Broussochalcone a, a potent antioxidant and effective suppressor of inducible nitric oxide synthase in lipopolysaccharide-activated macrophages. Biochem. Pharmacol., 61: 939-946.
    CrossRef  |  PubMed  |  Direct Link  |  
  282. Wu, S.N., T.L. Hwang, C.M. Teng, H.F. Li and C.R. Jan, 2000. The mechanism of actions of 3-(5'-(hydroxymethyl-2'-furyl)-1-benzyl indazole (YC-1) on Ca2+-activated K+ currents in GH3 lactotrophs. Neuropharmacology, 39: 1788-1799.
    CrossRef  |  Direct Link  |  
  283. Wu, C.C., S.W. Huang, T.L. Hwang, S.C. Kuo, F.Y. Lee and C.M. Teng, 2000. YD-3, a novel inhibitor of protease-induced platelet activation. Br. J. Pharmacol., 130: 1289-1296.
    CrossRef  |  Direct Link  |  
  284. Hwang, T.L., Y.A. Yeh, J.W. Chern and C.M. Teng, 2000. Pharmacological characterization of EK112, a new combined angiotensin II and thromboxane A2 receptor antagonist. Gen. Pharmacol. Vasc. Syst., 34: 25-31.
    CrossRef  |  Direct Link  |  
  285. Hwang, T.L., C.C. Wu and C.M. Teng, 1999. YC-1 potentiates nitric oxide-induced relaxation in guinea-pig trachea. Br. J. Pharmacol., 128: 577-584.
    CrossRef  |  Direct Link  |  
  286. Wu, S.N., S.I. Liu and T.L. Hwang, 1998. Activation of muscarinic K+ channels by extracellular ATP and UTP in rat atrial myocytes. J. Cardiovasc. Pharmacol., 31: 203-211.
    Direct Link  |  
  287. Hwang, T.L., C.C. Wu and C.M. Teng, 1998. Comparison of two soluble guanylyl cyclase inhibitors, methylene blue and ODQ, on sodium nitroprusside-induced relaxation in guinea-pig trachea. Br. J. Pharmacol., 125: 1158-1163.
    CrossRef  |  Direct Link  |  
  288. Guh, J.H., T.L. Hwang, F.N. Ko, S.C. Chueh, M.K. Lai and C.M. Teng, 1998. Antiproliferative effect in human prostatic smooth muscle cells by nitric oxide donor. Mol. Pharmacol., 53: 467-474.
    CrossRef  |  Direct Link  |  
  289. Guh, J.H., S.C. Chueh, T.L. Hwang, J. Chen and C.M. Teng, 1998. Cell proliferation in human prostatic smooth muscle cells involves the modulation of protein kinase C isozymes. Eur. J. Pharmacol., 359: 281-284.
    CrossRef  |  Direct Link  |  
  290. Wu, S.N., T.L. Hwang, C.R. Jan and C.J. Tseng, 1997. Ionic mechanisms of tetrandrine in cultured rat aortic smooth muscle cells. Eur. J. Pharmacol., 327: 233-238.
    CrossRef  |  Direct Link  |  
  291. Wu, S.N., A.Y. Shen and T.L. Hwang, 1996. Analysis of mechanical restitution and post-rest potentiation in isolated rat atrium. Chin. J. Physiol., 39: 23-29.
  292. Wu, B.N., T.L. Hwang, C.F. Liao and I.J. Chen, 1994. Vaninolol: A new selective β1-adrenoceptor antagonist derived from vanillin. Biochem. Pharmacol., 48: 101-109.
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