Dr. Juei Tang Cheng

Dr. Juei Tang Cheng

Professor
Chang Jung Christian University, Taiwan


Highest Degree
Ph.D. in Pharmacology from Shizuoka College of Pharmacy, Shizuika, Japan

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Area of Interest:

Pharmacology and Toxicology
100%
Insulin Resistance
62%
Metabolic Syndrome
90%
Natural Products
75%
Systemic Pharmacology
55%

Education

1978

Ph.D.

Shizuoka College of Pharmacy, Shizuika, Japan

Pharmacology

Selected Publications

  1. Wu, T.T.L., H.S. Niu, L.J. Chen, J.T. Cheng and Y.C. Tong, 2016. Increase of human prostate cancer cell (DU145) apoptosis by telmisartan through PPAR-delta pathway. Eur. J. Pharmacol., 775: 35-42.
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  2. Wang, C.M., C.T. Hsu, H.S. Niu, C.H. Chang, J.T. Cheng and J.M. Shieh, 2016. Lung damage induced by hyperglycemia in diabetic rats: The role of signal transducer and activator of transcription 3 (STAT3). J. Diabetes Complications, 30: 1426-1433.
    CrossRef  |  PubMed  |  Direct Link  |  

  3. Niu, H.S., P.C. Chao, P.M. Ku, C.S. Niu, K.S. Lee and J.T. Cheng, 2016. Amarogentin ameliorates diabetic disorders in animal models. Naunyn-Schmiedeberg's Arch. Pharmacol., 389: 1215-1223.
    CrossRef  |  PubMed  |  Direct Link  |  

  4. Niu, H.S., I.M. Liu, C.S. Niu, P.M. Ku, C.T. Hsu and J.T. Cheng, 2016. Eucommia bark (Du-Zhong) improves diabetic nephropathy without altering blood glucose in type 1-like diabetic rats. Drug Des. Dev. Ther., 10: 971-978.
    CrossRef  |  PubMed  |  Direct Link  |  

  5. Niu, H.S., C.H. Chang, C.S. Niu, J.T. Cheng and K.S. Lee, 2016. Erythropoietin ameliorates hyperglycemia in type 1-like diabetic rats. Drug Des. Dev. Ther., 10: 1877-1884.
    CrossRef  |  PubMed  |  Direct Link  |  

  6. Lo, S.H., K.C. Cheng, Y.X. Li, C.H. Chang, J.T. Cheng and K.S. Lee, 2016. Development of betulinic acid as an agonist of TGR5 receptor using a new in vitro assay. Drug Des. Dev. Ther., 10: 2669-2676.
    CrossRef  |  PubMed  |  Direct Link  |  

  7. Ku, M.C., C.M. Fang, J.T. Cheng, H.C. Liang and T.F. Wang et al., 2016. Site-specific covalent modifications of human insulin by catechol estrogens: Reactivity and induced structural and functional changes. Sci. Rep., Vol. 6. 10.1038/srep28804.
    CrossRef  |  PubMed  |  Direct Link  |  

  8. Chang, W.T., J.Y. Shih, Y.H. Feng, C.Y. Chiang and Y.H. Kuo et al., 2016. The early predictive value of right ventricular strain in epirubicin-induced cardiotoxicity in patients with breast cancer. Acta Cardiologica Sinica, 32: 550-559.
    PubMed  |  

  9. Chang, W.T., J.T. Cheng and Z.C. Chen, 2016. Telmisartan improves cardiac fibrosis in diabetes through peroxisome proliferator activated receptor δ (PPARδ): From bedside to bench. Cardiovasc. Diabetol., Vol. 15. 10.1186/s12933-016-0430-5.
    CrossRef  |  PubMed  |  Direct Link  |  

  10. Yang, T.T., H.S. Niu, L.J. Chen, P.M. Ku, K.C. Lin and J.T. Cheng, 2015. Canavanine induces insulin release via activation of imidazoline I3 receptors. Clin. Exp. Pharmacol. Physiol., 42: 263-268.
    CrossRef  |  PubMed  |  Direct Link  |  

  11. Tsai, C.C., T.W. Chuang, L.J. Chen, H.S. Niu, K.M. Chung, J.T. Cheng and K.C. Lin, 2015. Increase in apoptosis by combination of metformin with silibinin in human colorectal cancer cells. World J. Gastroenterol, 21: 4169-4177.
    CrossRef  |  PubMed  |  Direct Link  |  

  12. Niu, H.S., P.M. Ku, C.S. Niu, J.T. Cheng and K.S. Lee, 2015. Development of PPAR-agonist GW0742 as antidiabetic drug: Study in animals. Drug Des. Dev. Ther., 9: 5625-5632.
    CrossRef  |  PubMed  |  Direct Link  |  

  13. Lin, C.M., J.T. Tsai, C.K. Chang, J.T. Cheng and J.W. Lin, 2015. Development of telmisartan in the therapy of spinal cord injury: Pre-clinical study in rats. Drug Des. Dev. Ther., 93: 4709-4717.
    CrossRef  |  PubMed  |  Direct Link  |  

  14. Cheng, M.F., L.J. Chen, H.S. Niu, T.T. Yang, K.C. Lin and J.T. Cheng, 2015. Signals mediating klotho-induced neuroprotection in hippocampal neuronal cells. Acta Neurobiol. Exp., 75: 60-71.
    PubMed  |  Direct Link  |  

  15. Chen, L.J., M.F. Cheng, P.M. Ku and J.T. Cheng, 2015. Cerebral klotho protein as a humoral factor for maintenance of baroreflex. Hormone Metab. Res., 47: 125-132.
    CrossRef  |  PubMed  |  Direct Link  |  

  16. Chao, P.C., C.H. Chang, H.S. Niu, G.C. Huang, L.J. Chen and J.T. Cheng, 2015. Canavanine increases glucose uptake in C2C12 cells through the activation of imidazoline I-2B receptors. Clin. Exp. Pharmacol. Physiol., 42: 1045-1050.
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  17. Chang, C.H., P.C. Chao, H.S. Niu, G.C. Huang, L.J. Chen and J.T. Cheng, 2015. Canavanine activates imidazoline I-2 receptors to reduce hyperglycemia in type 1-like diabetic rats. Chemico-Biol. Interact., 240: 304-309.
    CrossRef  |  PubMed  |  Direct Link  |  

  18. Yeh, M.C., L.J. Chen, H.S. Niu, T.T. Yang, K.C. Lin and J.T. Cheng, 2014. Signals for increase of μ-opioid receptor expression in muscle by hyperglycemia. Neurosci. Lett., 582: 109-114.
    CrossRef  |  PubMed  |  Direct Link  |  

  19. Tsai, T.C., C.H. Lin, H.H. Chung, J.T. Cheng, I.H. Chen and Y.C. Tong, 2014. Urinary bladder relaxation through activation of imidazoline receptors induced by agmatine is increased in diabetic rats. LUTS, 6: 117-123.
    CrossRef  |  Direct Link  |  

  20. Tsai, C.C., K.S. Lee, S.H. Chen, L.J. Chen, K.F. Liu and J.T. Cheng, 2014. Decrease of PPAR in type-1-like diabetic rat for higher mortality after spinal cord injury. PPAR Res., Vol. 2014. 10.1155/2014/456386.
    CrossRef  |  PubMed  |  Direct Link  |  

  21. Sheu, J.R., P.A. Thomas and J.T. Cheng, 2014. Novel drugs development for cardio-/cerebrovascular diseases. Biomed Res. Int., Vol. 2014. 10.1155/2014/467936.
    CrossRef  |  PubMed  |  Direct Link  |  

  22. Kuo, S.C., H.H. Chung, C.H. Huang and J.T. Cheng, 2014. Decrease of hyperglycemia by syringaldehyde in diabetic rats. Hormone Metab. Res., 46: 8-13.
    CrossRef  |  Direct Link  |  

  23. Kang, L., C.H. Chen, M.H. Wu, J.K. Chang, F.M. Chang and J.T. Cheng, 2014. 17β-estradiol protects against glucosamine-induced pancreatic β-cell dysfunction. Menopause, 21: 1239-1248.
    CrossRef  |  PubMed  |  Direct Link  |  

  24. Huang, K.C., Y.G. Cherng, L.J. Chen, C.T. Hsu and J.T. Cheng, 2014. Rosiglitazone is effective to improve renal damage in type-1-like diabetic rats. Hormone Metab. Res., 46: 240-244.
    CrossRef  |  Direct Link  |  

  25. Fan, E.W.C., L.J. Chen, J.T. Cheng and Y.C. Tong, 2014. Changes of urinary bladder contractility in high-fat diet-fed mice: The role of tumor necrosis factor-α. Int. J. Urol., 21: 831-835.
    CrossRef  |  PubMed  |  Direct Link  |  

  26. Cheng, K.C., A. Asakawa, Y.X. Li, H.H. Chung and H. Amitani et al., 2014. Silymarin induces insulin resistance through an increase of phosphatase and tensin homolog in Wistar rats. PLoS One, 10.1371/journal.pone.0084550.
    CrossRef  |  Direct Link  |  

  27. Chang, P.C., L.J. Chen and J.T. Cheng, 2014. Role of peroxisome proliferator-activated receptors delta (PPARdelta) in rats showing endotoxemic heart failure. J. Appl. Biomed., 12: 79-85.
    Direct Link  |  

  28. Yang, T.T., P.M. Ku, C.T. Hsu, H.H. Chung, W.J. Lee and J.T. Cheng, 2013. Mediation of AMP Kinase in the increase of glucose uptake into L6 Cells induced by activation of imidazoline I-2 receptors. Hormone Metab. Res., 45: 359-363.
    CrossRef  |  Direct Link  |  

  29. Wang, L.Y., P.M. Ku, S.H. Chen, L.J. Chen, Y.M. Yu and J.T. Cheng, 2013. Characterization of the specificity of imidazoline I-1 receptor antibody for subtype of imidazoline receptors in vitro. Hormone Metab. Res., 45: 485-489.
    CrossRef  |  Direct Link  |  

  30. Wang, L.Y., P.M. Ku, S.H. Chen, H.H. Chung, Y.M. Yu and J.T. Cheng, 2013. Insulin resistance induced by zymosan as a new animal model in mice. Hormone Metab. Res., 45: 736-740.
    CrossRef  |  Direct Link  |  

  31. Wang, L.Y., H.H. Chung and J.T. Cheng, 2013. Decrease of plasma glucose by Hibiscus taiwanensis in type-1-like diabetic rats. Evidence Based Complementary Altern. Med., 10.1155/2013/356705.
    CrossRef  |  Direct Link  |  

  32. Tzeng, J.I., M.F. Chen, H.H. Chung and J.T. Cheng, 2013. Silymarin decreases connective tissue growth factor to improve liver fibrosis in rats treated with carbon tetrachloride. Phytother. Res., 27: 1023-1028.
    CrossRef  |  Direct Link  |  

  33. Su, C.H., L.J. Chen, J.F. Liao and J.T. Cheng, 2013. Increase of phosphatase and tensin homolog by silymarin to inhibit human pharynx squamous cancer. J. Med. Food, 16: 778-784.
    CrossRef  |  Direct Link  |  

  34. Su, C.H., L.J. Chen, J.F. Liao and J.T. Cheng, 2013. Dual effects of silymarin on nasopharyngeal carcinoma cells (NPC-TW01). Forsch Komplementmed., 20: 261-266.
    CrossRef  |  Direct Link  |  

  35. Piletz, J.E., F. Aricioglu, J.T. Cheng, C.A. Fairbanks and V.H. Gilad et al., 2013. Agmatine: clinical applications after 100 years in translation. Drug Discov. Today, 18: 880-893.
    CrossRef  |  Direct Link  |  

  36. Mar, G.Y., P.M. Ku, L.J. Chen, K.C. Cheng, Y.X. Li and J.T. Cheng, 2013. Increase in cardiac M2-muscarinic receptor expression is regulated by GATA binding protein 4 (GATA-4) in streptozotocin-induced diabetic rats. Int. J. Cardiol., 167: 436-441.
    CrossRef  |  Direct Link  |  

  37. Mar, G.Y., M.T. Chou, H.H. Chung, N.H. Chiu, M.F. Chen and J.T. Cheng, 2013. Changes of imidazoline receptors in spontaneously hypertensive rats. Int. J. Exp. Pathol., 94: 17-24.
    CrossRef  |  Direct Link  |  

  38. Lo, S.H., K.S. Lee, L.J. Chen, J.T. Cheng and C.H. Chen, 2013. Increase of PPARδ by dopamine mediated via DA-1 receptor-linked phospholipase C pathway in neonatal rat cardiomyocytes. Auton. Neurosci., 177: 211-216.
    CrossRef  |  Direct Link  |  

  39. Li, Y.X., K.C. Cheng, A. Asakawa, I. Kato and Y. Sato et al., 2013. Role of musclin in the pathogenesis of hypertension in rat. PLoS One, 10.1371/journal.pone.0072004.
    CrossRef  |  Direct Link  |  

  40. Lee, W.J., H.H. Chung, Y.Z. Cheng, H.H. Lin and J.T. Cheng, 2013. Rhodiola-water extract induces B-endorphin secretion to lower blood pressure in spontaneously hypertensive rats. Phytother. Res., 27: 1543-1547.
    CrossRef  |  Direct Link  |  

  41. Lee, L.M., C.H. Lin, H.H. Chung, J.T. Cheng, I.H. Chen and Y.C. Tong, 2013. Agmatine induces rat prostate relaxation through activation of peripheral imidazoline I2-receptors. LUTS, 5: 39-43.
    CrossRef  |  Direct Link  |  

  42. Lai, Y.H., L.J. Chen and J.T. Cheng, 2013. Role of TNF-a in renal damage in mice showing hepatic steatosis induced by high fat diet. Hormone Metab. Res., 45: 38-42.
    CrossRef  |  Direct Link  |  

  43. Kuo, S.C., P.M. Ku, L.J. Chen, H.S. Niu and J.T. Cheng, 2013. Activation of receptors δ (PPARδ) by agonist (GW0742) may enhance lipid metabolism in heart both In Vivo and In Vitro. Hormone Metab. Res., 45: 880-886.
    CrossRef  |  Direct Link  |  

  44. Huang, C.W., M.C. Lai, J.T. Cheng, J.J. Tsai, C.C. Huang and S.N. Wu, 2013. Pregabalin attenuates excitotoxicity in diabetes. PLoS One, 10.1371/journal.pone.0065154.
    CrossRef  |  Direct Link  |  

  45. Chung, H.H., K.S. Lee and J.T. Cheng, 2013. Decrease of obesity by allantoin via imidazoline I 1 -receptor activation in high fat diet-fed mice. Evidence Based Complementary Altern. Med., 10.1155/2013/589309.
    CrossRef  |  Direct Link  |  

  46. Chung, H.H. and J.T. Cheng, 2013. Improvement of obesity by activation of I1-imidazoline receptors in high fat diet-fed mice. Hormone Metab. Res., 45: 581-585.
    CrossRef  |  Direct Link  |  

  47. Cherng, Y.G., C.C. Tsai, H.H. Chung, Y.W. Lai, S.C. Kuo and J.T. Cheng, 2013. Antihyperglycemic action of sinapic acid in diabetic rats. J. Agric. Food Chem., 61: 12053-12059.
    CrossRef  |  Direct Link  |  

  48. Cheng, K.C., A. Asakawa, Y.X. Li, I.M. Liu, H. Amitani, J.T. Cheng and A. Inui, 2013. Opioid μ-receptors as new target for insulin resistance. Pharmacol. Ther., 139: 334-340.
    CrossRef  |  Direct Link  |  

  49. Chen, Z.C., L.J. Chen and J.T. Cheng, 2013. Doxorubicin-induced cardiac toxicity is mediated by lowering of peroxisome proliferator-activated receptor δ expression in rats. PPAR Res., 10.1155/2013/456042.
    CrossRef  |  Direct Link  |  

  50. Chen, Z.C., K.S. Lee, L.J. Chen, L.Y. Wang, H.S. Niu and J.T. Cheng, 2013. Cardiac peroxisome proliferator-activated receptor δ (PPARδ) as a new target for increased contractility without altering heart rate. PLoS One, 10.1371/journal.pone.0064229.
    CrossRef  |  Direct Link  |  

  51. Chen, Z.C., B.C. Yu, L.J. Chen and J.T. Cheng, 2013. Increase of peroxisome proliferator-activated receptors δ (PPARδ) by digoxin to improve lipid metabolism in the heart of diabetic rats. Hormone Metab. Res., 45: 364-371.
    CrossRef  |  Direct Link  |  

  52. Chen, Y.W., P.L. Hsieh, Y.C. Chen, C.H. Hung and J.T. Cheng, 2013. Physical exercise induces excess hsp72 expression and delays the development of hyperalgesia and allodynia in painful diabetic neuropathy rats. Anesth Analg., 116: 482-490.
    CrossRef  |  Direct Link  |  

  53. Yu, H.C., L.J. Chen, K.C. Cheng, Y.X. Li, C.H. Yeh and J.T. Cheng, 2012. Silymarin inhibits cervical cancer cell through an increase of phosphatase and tensin homolog (PTEN). Phytother. Res., 26: 709-715.
    CrossRef  |  Direct Link  |  

  54. Yang, T.T., N.H. Chiu, H.H. Chung, C.T. Hsu, W.J. Lee and J.T. Cheng, 2012. Stimulatory effect of allantoin on imidazoline I1 receptors in animal and cell line. Hormone Metab. Res., 44: 879-884.
    CrossRef  |  Direct Link  |  

  55. Yang, P.S., H.T. Wu, H.H. Chung, C.T. Chen, C.W. Chi, C.H. Yeh and J.T. Cheng, 2012. Rilmenidine improves hepatic steatosis through p38-dependent pathway to higher the expression of farnesoid X receptor. Naunyn-Schmiedebergs Arch. Pharmacol., 385: 51-56.
    CrossRef  |  Direct Link  |  

  56. Wu, H.T., W. Chen, K.C. Cheng, P.M. Ku, C.H. Yeh and J.T. Cheng, 2012. Oleic acid activates peroxisome proliferator-activated receptor to compensate insulin resistance in steatotic cells. J. Nutrit. Biochem., 23: 1264-1270.
    CrossRef  |  Direct Link  |  

  57. Lin, K.C., L.R. Yeh, L.J. Chen, Y.J. Wen, K.C. Cheng and J.T. Cheng, 2012. Plasma glucose-lowering action of allantoin is induced by activation of imidazoline I-2 receptors in streptozotocin-induced diabetic rats. Hormone Metab. Res., 44: 41-46.
    CrossRef  |  Direct Link  |  

  58. Lin, C.C., L.T. Lin, M.H. Yen, J.T. Cheng, C.H. Yeh and C.H. Hsing, 2012. Renal protective effect of Xiao-Chai-Hu-Tang on diabetic nephropathy of type 1-diabetic mice. Evidence-Based Complementary Altern. Med., 10.1155/2012/984024.
    CrossRef  |  Direct Link  |  

  59. Lee, L.M., T.C. Tsai, H.H. Chung, Y.C. Tong and J.T. Cheng, 2012. Prostatic relaxation induced by agmatine is decreased in spontaneously hypertensive rats. BJU Int., 110: 253-258.
    CrossRef  |  Direct Link  |  

  60. Lee, L.M., C.S. Lin, H.H. Chung, K.C. Lin and J.T. Cheng, 2012. Urinary bladder relaxation through activation of opioid μ-receptors induced by loperamide is increased in diabetic rats. Exp. Clin. Endocrinol. Diabetes, 120: 323-328.
    CrossRef  |  Direct Link  |  

  61. Lee, L.M., C.C. Lu, H.H. Chung and J.T. Cheng, 2012. Prostatic relaxation induced by loperamide is reduced in spontaneously hypertensive rats. Sci. World J., 10.1100/2012/941685.
    CrossRef  |  Direct Link  |  

  62. Kang, L., C.H. Chen, Y.C. Cheng, C.H. Chang and C.T. Lee et al., 2012. Glucosamine-induced insulin resistance in ovariectomized rats is relevant to decreasing the expression of glucose transport protein subtype 4 in the skeletal muscle and in increasing the size of pancreatic islets. Menopause, 19: 496-502.
    CrossRef  |  Direct Link  |  

  63. Huang, C.H., M.F. Chen, H.H. Chung and J.T. Cheng, 2012. Antihyperglycemic effect of syringaldehyde in streptozotocin-induced diabetic rats. J. Nat. Prod., 75: 1465-1468.
    CrossRef  |  Direct Link  |  

  64. Chung, H.H., T.T. Yang, M.F. Chen, M.T. Chou and J.T. Cheng, 2012. Improvement of Hyperphagia by Activation of Cerebral I1-Imidazoline Receptors in Streptozotocin-induced Diabetic Mice. Hormone Metab. Res., 44: 645-649.
    CrossRef  |  Direct Link  |  

  65. Chou, M.T., S.H. Lo, K.C. Cheng, Y.X. Li, L.J. Chen and J.T. Cheng, 2012. Activation of B-adrenoceptors by dobutamine may induce a higher expression of peroxisome proliferator-activated receptors δ (PPARδ) in neonatal rat cardiomyocytes. Sci. World J., 10.1100/2012/248320.
    CrossRef  |  Direct Link  |  

  66. Cheng, Y.Z., L.J. Chen, W.J. Lee, M.F. Chen, H.J. Lin and J.T. Cheng, 2012. Increase of myocardial performance by Rhodiola-ethanol extract in diabetic rats. J. Ethnopharmacol., 144: 234-239.
    CrossRef  |  Direct Link  |  

  67. Cheng, K.C., Y.X. Li, A. Asakawa, M. Ushikai and I. Kato et al., 2012. Characterization of preptin-induced insulin secretion in pancreatic B-cells. J. Endocrinol., 215: 43-49.
    CrossRef  |  Direct Link  |  

  68. Cheng, K.C., Y.X. Li and J.T. Cheng, 2012. The use of herbal medicine in cancer-related anorexia/ cachexia treatment around the world. Curr. Pharm. Des., 18: 4819-4826.
    CrossRef  |  Direct Link  |  

  69. Chen, W., H.H. Chung and J.T. Cheng, 2012. Opiate-induced constipation is related to the activation of opioid mu2-receptors in small intestine of mice. World J. Gastroenterol., 18: 1391-1396.
    CrossRef  |  Direct Link  |  

  70. Chen, M.F., T.T. Yang, L.R. Yeh, H.H. Chung, Y.J. Wen, W.J. Lee and J.T. Cheng, 2012. Activation of imidazoline I-2B receptors by allantoin to increase glucose uptake into C2C12 Cells. Hormone Metab. Res., 44: 268-272.
    Direct Link  |  

  71. Chen, I.H., Y.C. Tong and J.T. Cheng, 2012. Metabolic syndrome decreases tissue perfusion and induces glandular hyperplasia in the fructose-fed rat prostate. Neurourol. Urodyn., 31: 600-604.
    CrossRef  |  Direct Link  |  

  72. Chen, I.H., H.H. Chung, J.T. Cheng and Y.C. Tong, 2012. Metabolic syndrome enhances prostate contractility and in vitro phenylephrine-induced a1-adrenoceptor protein expression in the fructose-fed rat. LUTS, 5: 164-167.
    CrossRef  |  Direct Link  |  

  73. Yeh, C.H., C.K. Chang, K.C. Cheng, Y.X. Li, Y.W. Zhang and J.T. Cheng, 2011. Role of bone morphogenetic proteins-7 (BMP-7) in the renal improvement effect of DangGui (Angelica sinensis) in type 1-diabetic rats. Evidence Based Complementary Altern. Med., 10.1155/2011/796723.
    CrossRef  |  Direct Link  |  

  74. Wu, H.T., C.T. Chen, K.C. Cheng, Y.X. Li, C.H. Yeh and J.T. Cheng, 2011. Pharmacological activation of peroxisome proliferator-activated receptor δ improves insulin resistance and hepatic steatosis in high fat diet-induced diabetic mice. Hormone Metab. Res., 43: 631-635.

  75. Shieh, J.P., K.C. Cheng, H.H. Chung, Y.F. Kerh, C.H. Yeh and J.T. Cheng, 2011. Plasma glucose lowering mechanisms of Catalpol, an active principle from roots of Rehmannia glutinosa , in streptozotocin-induced diabetic rats. J. Agric. Food Chem., 59: 3747-3753.
    CrossRef  |  Direct Link  |  

  76. Ou, H.Y., H.T. Wu, Y.C. Yang, J.S. Wu, J.T. Cheng and C.J. Chang, 2011. Elevated retinol binding protein 4 contributes to insulin resistance in spontaneously hypertensive rats. Hormone Metab., 43: 312-318.

  77. Niu, C.S., H.T Wu, K.C. Cheng, K.C. Lin, C.T. Chen and J.T. Cheng, 2011. A novel mechanism for decreasing plasma lipid level from imidazoline I-1 receptor activation in high fat diet-fed mice. Hormone Metab., 43: 458-463.

  78. Niu, C.S., C.T. Chen, L.J. Chen, K.C. Cheng, C.H. Yeh and J.T. Cheng, 2011. Decrease of blood lipids induced by Shan-Zha (fruit of Crataegus pinnatifida) is mainly related to an increase of PPAR in liver of mice fed high-fat diet. Hormone Metab. Res., 43: 625-630.

  79. Liu, C.L., H.T. Wu, Y.H. Hsiao, C.W. Lai and C.W. Shih et al., 2011. Insulin-directed synthesis of fluorescent gold nanoclusters: Preservation of insulin bioactivity and versatility in cell imaging. Angew. Chem. Int. Ed. Eng., 50: 7056-7060.
    CrossRef  |  Direct Link  |  

  80. Lin, R.T., C.Y. Chen, C.Y. Tzeng, Y.C. Lee and Y.W. Cheng et al., 2011. Electroacupuncture improves glucose tolerance through cholinergic nerve and nitric oxide synthase effects in rats. Neurosci. Lett., 494: 114-118.
    CrossRef  |  Direct Link  |  

  81. Lee, J.P., W. Chen, H.T. Wu, K.C. Lin and J.T. Cheng, 2011. Metformin can activate imidazoline I-2 receptors to lower plasma glucose in type 1-like diabetic rats. Hormone Metab. Res., 43: 26-30.
    CrossRef  |  PubMed  |  Direct Link  |  

  82. Lee, J.P., K.C. Cheng, H.H. Chung, H.T. Wu, C.T. Chen and J.T. Cheng, 2011. Inhibition of insulin degrading enzyme by racecadotril in the brain of Wistar rats. Hormone Metab. Res., 43: 489-493.

  83. Ku, P.M., L.J. Chen, J.R. Liang, K.C. Cheng, Y.X. Li and J.T. Cheng, 2011. Molecular role of GATA binding protein 4 (GATA-4) in hyperglycemia-induced reduction of cardiac contractility. Cardiovasc. Diabetol., 10.1186/1475-2840-10-57.
    CrossRef  |  Direct Link  |  

  84. Fong,Y., K.H. Shen, L.J. Chen and J.T. Cheng, 2011. Changes of CCAAT enhancer-binding proteins (CEBPs) in the lung of streptozotocin-induced diabetic rats. Hormone Metab., 43: 261-267.

  85. Chiu, Y.J., H.H. Chung, C.H. Yeh, J.T. Cheng and S.H. Lo, 2011. Improvement of insulin resistance by Chlorella in fructose-rich chow-fed rats. Phytother. Res., 25: 1306-1312.
    CrossRef  |  Direct Link  |  

  86. Cheng, J.T., I.H. Chen, B.C. Yu and Y.C. Tong, 2011. Loperamide-induced rat prostate relaxation through activation of peripheral -opioid receptors. Neurourol. Urodyn., 30: 468-471.
    CrossRef  |  Direct Link  |  

  87. Chen, Z.C., J.P. Shieh, H.H. Chung, C.H. Hung, H.J. Lin and J.T. Cheng, 2011. Activation of peripheral opioid μ-receptors in blood vessel may lower blood pressure in spontaneously hypertensive rats. Pharmacol., 87: 257-264.
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  88. Chen, Z.C., B.C. Yu, L.J. Chen, K.C. Cheng, H.J. Lin and J.T. Cheng, 2011. Characterization of the mechanisms of the increase in PPARδ expression induced by digoxin in the heart using the H9c2 cell line. Br. J. Pharmacol., 163: 390-398.
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  89. Chen, C.T., W. Chen, H.H. Chung, K.C. Cheng, C.H. Yeh and J.T. Cheng, 2011. Activation of imidazoline I-2B receptor by metformin to increase glucose uptake in skeletal muscle. Hormone Metab. Res., 43: 708-713.
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  90. Yang, T.T., S.M. Ling, C.W. Tsao and J.T. Cheng, 2010. Opening of ATP-sensitive potassium channel by insulin in the brain-induced insulin secretion in Wistar rats. Hormone Metab. Res., 42: 110-114.
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  91. Wu, H.T., W. Chen, K.C. Cheng, C.H. Yeh, K.H. Shen and J.T. Cheng, 2010. Indomethacin activates peroxisome proliferator-Activated receptor γ to improve insulin resistance in cotton pellet granuloma model. Hormone Metab. Res., 42: 775-780.
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  92. Wu, H.T., C.K. Chang, K.C. Cheng, C.H. Chang, C.H. Yeh and J.T. Cheng, 2010. Increase of plasma insulin by racecadotril, an inhibitor of enkephalinase, in Wistar rats. Hormone Metab. Res., 42: 261-267.
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  93. Lui, T.N., C.W. Tsao, S.Y. Huang, C.H. Chang and J.T. Cheng, 2010. Activation of imidazoline I2B receptors is linked with AMP kinase pathway to increase glucose uptake in cultured C2C12 cells. Neurosci. Lett., 474: 144-147.
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  94. Lee, K.S., W.J. Yu, M.J. Wang, H.T. Wu, C.H. Chang and J.T. Cheng, 2010. Autonomic regulation of insulin secretion is changed by pentobarbital in mice. Neurosci. Lett., 479: 6-9.
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  95. Lee, K.S., A. Nishimune, H. Yoshiki, A.S. Anisuzzaman and F. Suzuki et al., 2010. Assessment of novel muscarinic acetylcholine receptors in rat cerebral cortex by a tissue segment binding method. J. Pharmacol. Sci., 112: 444-451.
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  96. Lee, H.H., C.H. Yeh, Y.T. Chen, T.C. Chi, J.T. Cheng and S.H. Lo, 2010. Effects of metformin on rosiglitazone-induced cardiac hypertrophy in mice. Biol. Pharma. Bull., 33: 1506-1510.
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  97. Huang, W.J., H.S. Niu, M.H. Lin, J.T. Cheng and F.L. Hsu, 2010. Antihyperglycemic effect of catalpol in streptozotocin-induced diabetic rats. J. Nat. Prod., 73: 1170-1172.
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  98. Fan, S.C., B.C. Yu, Z.C. Chen, L.J. Chen, H.H. Chung and J.T. Cheng, 2010. The decreased expression of peroxisome proliferator-activated receptors δ (PPARδ) is reversed by digoxin in the heart of diabetic rats. Hormone Metab. Res., 42: 637-642.
    CrossRef  |  PubMed  |  Direct Link  |  

  99. Cheng, T.C., C.C. Lu, H.H. Chung, C.C. Hsu and N. Kakizawa et al., 2010. Activation of muscarinic M-1 cholinoceptors by curcumin to increase contractility in urinary bladder isolated from Wistar rats. Neurosci. Lett., 473: 107-109.
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  100. Chang, C.H., H.T. Wu, K.C. Cheng, H.J. Lin and J.T. Cheng, 2010. Increase of β-endorphin secretion by agmatine is induced by activation of imidazoline I2A receptors in adrenal gland of rats. Neurosci. Lett., 468: 297-299.
    CrossRef  |  PubMed  |  Direct Link  |  

  101. Yeh, C.H., C.K. Chang, M.F. Cheng, H.J. Lin and J.T. Cheng, 2009. The antioxidative effect of bone morphogenetic protein-7 against high glucose-induced oxidative stress in mesangial cells. Biochem. Biophys. Res. Commun., 382: 292-297.
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  102. Yeh, C.H., C.K. Chang, M.F. Cheng, H.J. Lin and J.T. Cheng, 2009. Decrease of bone morphogenetic protein-7 (BMP-7) and its type II receptor (BMP-RII) in kidney of type 1-like diabetic rats. Hormone Metab. Res., 41: 605-611.
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  103. Yang, T.T., I.M. Liu, H.T. Wu and J.T. Cheng, 2009. Mediation of protein kinase C zeta in μ-opioid receptor activation for increase of glucose uptake into cultured myoblast C2C12 cells. Neurosci. Lett., 465: 177-180.
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  104. Yang, T.T., C.K. Chang, C.W. Tsao, Y.M. Yu, C.T. Hsu and J.T. Cheng, 2009. Activation of muscarinic M-3 receptor may decrease glucose uptake and lipolysis in adipose tissue of rats. Neurosci. Lett., 451: 57-59.
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  105. Yang, P.S., J.J. Lee, C.W. Tsao, H.T. Wu and J.T. Cheng, 2009. Stimulatory effect of stevioside on peripheral mu opioid receptors in animals. Neurosci. Lett., 454: 72-75.
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  106. Su, C.H., I.M. Liu, H.H. Chung and J.T. Cheng, 2009. Activation of I2-imidazoline receptors by agmatine improved insulin sensitivity through two mechanisms in type-2 diabetic rats. Neurosci. Lett., 457: 125-128.
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  107. Shieh, J.M., H.T. Wu, K.C. Cheng and J.T. Cheng, 2009. Melatonin ameliorates high fat diet-induced diabetes and stimulates glycogen synthesis via a PKCζ-Akt-GSK3β pathway in hepatic cells. J. Pineal Res., 47: 339-344.
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  108. Pai, H.C., C.Y. Tzeng, Y.C. Lee, C.H. Chang, J.G. Lin, J.T. Cheng and S.L. Chang, 2009. Increase in plasma glucose lowering action of rosiglitazone by electroacupuncture at bilateral Zusanli acupoints (ST.36) in rats. J. Acupunct. Meridian. Stud., 2: 147-151.
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  109. Niu, C.S., C.H. Yeh, M.F. Yeh and J.T. Cheng, 2009. Increase of adipogenesis by ginsenoside (Rh2) in 3T3-L1 cell via an activation of glucocorticoid receptor. Hormone Metab. Res., 41: 271-276.
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  110. Liu, I.M. and J.T. Cheng, 2009. Mediation of endogenous β-endorphin in the plasma glucose-lowering action of herbal products observed in type 1-like diabetic rats. Evid Based Complement Alternat Med 10.1093/ecam/nen078.
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  111. Lin, R.T., C.Y. Tzeng, Y.C. Lee, W.J. Ho, J.T. Cheng, J.G. Lin and S.L. Chang, 2009. Acute effect of electroacupuncture at the Zusanli acupoints on decreasing insulin resistance as shown by lowering plasma free fatty acid levels in steroid-background male rats. BMC Complement Alternat Med., 9: 26-26.
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  112. Lin, C.L., A.S. Dumont, Y.F. Su, Z.K. Dai and J.T. Cheng et al., 2009. Attenuation of subarachnoid hemorrhage-induced apoptotic cell death with 17 beta-estradiol: laboratory investigation. J. Neurosurg., 111: 1014-1022.
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  113. Kuo, D.H., C.H. Yeh, P.C. Shieh, K.C. Cheng, F.A. Chen and J.T. Cheng, 2009. Effect of ShanZha, a Chinese herbal product, on obesity and dyslipidemia in hamsters receiving high-fat diet. J. Ethnopharmacol., 124: 544-550.
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  114. Huang, C.W., J.T. Cheng, J.J. Tsai, S.N. Wu and C.C. Huang, 2009. Diabetic hyperglycemia aggravates seizures and status epilepticus-induced hippocampal damage. Neurotoxicity Res., 15: 71-81.
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  115. Chien, C.S., S.C. Cheng, H.T. Wu, C.W. Tsao and J.T. Cheng, 2009. Insulin resistance induced by glucosamine in fructose-fed rats. Hormone Metab. Res., 41: 542-547.
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  116. Cheng, T.C., C.S. Lin, C.C. Hsu, L.J. Chen, K.C. Cheng and J.T. Cheng, 2009. Activation of muscarinic M-1 cholinoceptors by curcumin to increase glucose uptake into skeletal muscle isolated from Wistar rats. Neurosci. Lett., 465: 238-241.
    CrossRef  |  PubMed  |  Direct Link  |  

  117. Chang, C.H., C.W. Tsao, S.Y. Huang and J.T. Cheng, 2009. Activation of imidazoline I2B receptors by guanidine to increase glucose uptake in skeletal muscle of rats. Neurosci. Lett., 467: 147-149.
    Direct Link  |  

  118. Chan, P., I.M. Liu, Y.X. Li, W.J. Yu and J.T. Cheng, 2009. Antihypertension induced by tanshinone IIA isolated from the roots of Salvia Miltiorrhiza. Evid Based Complement Alternat Med 10.1093/ecam/nep056.
    CrossRef  |  PubMed  |  Direct Link  |  

  119. Liu, I.M., S.S. Liou and J.T. Cheng, 2006. Mediation of beta-endorphin by myricetin to lower plasma glucose in streptozotocin-induced diabetic rats. J. Ethanopharmacol., 104: 199-206.
    CrossRef  |  PubMed  |  Direct Link  |  

  120. Lai, D.M., Y.K. Tu, I.M. Liu, P.F. Chen and J.T. Cheng, 2006. Mediation of β-endorphin by ginsenoside Rh2 to lower plasma glucose in streptozotocin-induced diabetic rats. Planta Med., 72: 9-13.
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