Dr. Jaw Wen Chen
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Dr. Jaw Wen Chen

Professor
National Yang-Ming University, Taiwan

Highest Degree
PostDoc Fellow in Vascular Medicine and Biology from Stanford University, California, USA

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Biography

Dr. Jaw-Wen Che is currently working as Professor of Medicine in Institute of Pharmacology and the Associate Dean in the Office of Research and Development in National Yang-Ming University, Taipei, Taiwan. He is also the Director of Clinical Research and a Visiting Cardiologist in Taipei Veterans General Hospital. He has been trained as a Post-Doctoral Fellow in Vascular Biology and Medicine in Stanford University Cardiovascular Research Center. He focused his researches on vascular biology and molecular biology related to oxidative stress, vascular inflammation, and endothelial dysfunction, high glucose and atherogenesis, 3) drugs or chemicals with antioxidant capacity for atherogenesis and hypertension, inflammatory biomarkers in clinical cardiovascular diseases and vascular progenitor cells for vascular repair and angiogenesis. He has published more than 240 scientific papers. He is the follow of American Heart Association, European Society of Cardiology, and Asia-Pacific Society of Cardiology. He reviews papers for more than 50 international journals including Circulation, JACC, European Heart journal, Diabetes, Hypertension, ATVB, and so on. Since 2012, he serves as the Editor-in-Chief of Acta Cardiologica Sinica and is currently the Editorial Board for 10 international journals.

Area of Interest:

Medicine
100%
Atherosclerosis
62%
Vascular Biology
90%
Vascular Progenitor Cells
75%
Secondary Hypertension
55%

Research Publications in Numbers

Books
0
Chapters
1
Articles
391
Abstracts
3

Selected Publications

  1. Yang, T.L., T.C. Wu, C.C. Huang, P.H. Huang and C.M. Chung et al., 2014. Association of tamoxifen use and reduced cardiovascular events among Asian females with breast cancer. Circ. J., 78: 135-140.
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  2. Wu, C.C., P.H. Huang, C.L. Lai, H.B. Leu, J.W. Chen and S.J. Lin, 2014. The impact of endothelial progenitor cells on restenosis after percutaneous angioplasty of hemodialysis vascular access. PLoS ONE, Vol. 9. 10.1371/journal.pone.0101058.
    CrossRef  |  Direct Link  |  
  3. Tsai, K.L., P.H. Huang, C.L. Kao, H.B. Leu and Y.H. Cheng et al., 2014. Aspirin attenuates vinorelbine-induced endothelial inflammation via modulating SIRT1/AMPK axis. Biochem. Pharmacol., 88: 189-200.
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  4. Tsai, D.C., S.J. Chen, C.C. Huang, P. Chou and C.M. Chung et al., 2014. Risk of central serous chorioretinopathy in adults prescribed oral corticosteroids: A population-based study in Taiwan. Retina, 34: 1867-1874.
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  5. Lu, D.Y., C.C. Huang, P.H. Huang, C.M. Chung and S.J. Lin et al., 2014. Metformin use in patients with type 2 diabetes mellitus is associated with reduced risk of deep vein thrombosis: A non-randomized, pair-matched cohort study. BMC Cardiovasc. Disord., Vol. 14. 10.1186/1471-2261-14-187.
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  6. Lin, T.H., S.Y. Chuang, C.Y. Chu, W.H. Lee and P.C. Hsu et al., 2014. The impact of chronic kidney disease on lipid management and goal attainment in patients with atherosclerosis diseases in Taiwan. Int. J. Med. Sci., 11: 381-388.
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  7. Lin, L.Y., C.C. Huang, J.S. Chen, T.C. Wu and H.B. Leu et al., 2014. Effects of pitavastatin versus atorvastatin on the peripheral endothelial progenitor cells and vascular endothelial growth factor in high-risk patients: A pilot prospective, double-blind, randomized study. Cardiovasc. Diabetol., Vol. 13. 10.1186/s12933-014-0111-1.
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  8. Li, S.Y., P.H. Huang, A.H. Yang, D.C. Tarng and W.C. Yang et al., 2014. Matrix metalloproteinase-9 deficiency attenuates diabetic nephropathy by modulation of podocyte functions and dedifferentiation. Kidney Int., 86: 358-369.
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  9. Leu, H.B., C.M. Chung, S.J. Lin, T.M. Lu and H.C. Yang et al., 2014. A novel SNP associated with nighttime pulse pressure in young-onset hypertension patients could be a genetic prognostic factor for cardiovascular events in a general cohort in Taiwan. PLoS ONE, Vol. 9. 10.1371/journal.pone.0097919.
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  10. Kao, C.L., Y.Y. Cheng, H.B. Leu, T.J. Chen and H.I. Ma et al., 2014. Increased risk of ischemic stroke in patients with benign paroxysmal positional vertigo: A 9-year follow-up nationwide population study in Taiwan. Front. Aging Neurosci., Vol. 6. 10.3389/fnagi.2014.00108.
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  11. Huang, S.S., Y.H. Chen, W.L. Chan, P.H. Huang, J.W. Chen and S.J. Lin, 2014. Usefulness of the CHADS2 score for prognostic stratification of patients with acute myocardial infarction. Am. J. Cardiol., 114: 1309-1314.
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  12. Huang, P.H., J.W. Chen and S.J. Lin, 2014. Effects of cardiovascular risk factors on endothelial progenitor cell. Acta Cardiol. Sin., 30: 375-381.
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  13. Huang, C.C., C.M. Chung, S.I. Hung, H.B. Leu and L.Y. Lin et al., 2014. Genetic predictors of thiazide-induced serum potassium changes in nondiabetic hypertensive patients. Hypertens. Res., 37: 759-764.
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  14. Huang, C.C., C.M. Chung, H.B. Leu, L.Y. Lin and C.C. Chiu et al., 2014. Diabetes mellitus and the risk of Alzheimer's disease: A nationwide population-based study. PLoS ONE, Vol. 9. 10.1371/journal.pone.0087095.
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  15. Chung, C.M., T.H. Lin, J.W. Chen, H.B. Leu and W.H. Yin et al., 2014. Common quantitative trait locus downstream of RETN gene identified by genome-wide association study is associated with risk of type 2 diabetes mellitus in Han Chinese: A Mendelian randomization effect. Diabetes Metab. Res. Rev., 30: 232-240.
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  16. Chiang, K.M., H.C. Yang, Y.J. Liang, J.W. Chen and S.M. Hwang et al., 2014. A three-stage genome-wide association study combining multilocus test and gene expression analysis for young-onset hypertension in Taiwan Han Chinese. Am. J. Hypertens., 27: 819-827.
    PubMed  |  Direct Link  |  
  17. Chiang, C.H., P.H. Huang, C.C. Chiu, C.Y. Hsu and H.B. Leu et al., 2014. Reduction of circulating endothelial progenitor cell level is associated with contrast-induced nephropathy in patients undergoing percutaneous coronary and peripheral interventions. PLoS ONE, Vol. 9. 10.1371/journal.pone.0089942.
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  18. Chiang, C.H., C.J. Liu, P.J. Chen, C.C. Huang and C.Y. Hsu et al., 2014. Primary Sjogren�s syndrome and risk of ischemic stroke: A nationwide study. Clin. Rheumatol., 33: 931-937.
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  19. Chen, C.Y., S.Y. Chuang, C.C. Fang, L.C. Huang and I.C. Hsieh et al., 2014. Gender disparities in optimal lipid control among patients with coronary artery disease. J. Atheroscler. Thromb., 21: S20-S28.
  20. Chang, C.C., C.C. Chiu, C.H. Chiang, C.C. Huang and W.L. Chan et al., 2014. Obstructive sleep apnea and the risk of ischemic stroke in patients with atrial fibrillation. Int. J. Cardiol., 181: 144-146.
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  21. Chan, W.L., K.P. Yang, T.F. Chao, C.C. Huang and P.H. Huang et al., 2014. The association of asthma and atrial fibrillation-A nationwide population-based nested case-control study. Int. J. Cardiol., 176: 464-469.
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  22. Ye, Z.X., C.M. Hsueh, H.B. Leu and J.W. Chen, 2011. Recurrence of esophageal cancer presents as transient ischemic attack. J. Chin Med. Assoc., 74: 176-178.
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  23. Yang, Y.Y., F.Y. Lee, H.C. Hsu, C.C. Huang and J.W. Chen et al., 2011. A core competence-based objective structured clinical examination (OSCE) in evaluation of clinical performance of postgraduate year-1 (PGY1) residents. J. Chin Med. Assoc., 74: 198-204.
    CrossRef  |  PubMed  |  Direct Link  |  
  24. Sung, S.H., T.C. Wu, C.H. Huang, S.J. Lin and J.W. Chen, 2011. Prognostic impact of body mass index in patients undergoing coronary artery bypass surgery. Heart, 97: 648-654.
    CrossRef  |  PubMed  |  Direct Link  |  
  25. Leu, H.B., C.M. Chung, S.Y. Chuang, C.H. Bai, J.R. Chen, J.W. Chen and W.H. Pan, 2011. Genetic variants of connexin37 are associated with carotid intima-medial thickness and future onset of ischemic stroke. Atherosclerosis, 214: 101-106.
    CrossRef  |  PubMed  |  Direct Link  |  
  26. Leu, H.B., C.M. Chung, S.J. Lin, Y.S. Jong, W.H. Pan and J.W. Chen, 2011. Adiponectin gene polymorphism is selectively associated with the concomitant presence of metabolic syndrome and essential hypertension. PLoS ONE, 6: e19999-e19999.
    CrossRef  |  PubMed  |  Direct Link  |  
  27. Huang, P.H., J.S. Chen, H.Y. Tsai, Y.H. Chen and F.Y. Lin et al., 2011. Globular adiponectin improves high glucose-suppressed endothelial progenitor cell function through endothelial nitric oxide synthase dependent mechanisms. J. Mol. Cell. Cardiol., 51: 109-119.
    CrossRef  |  PubMed  |  Direct Link  |  
  28. Huang, C.C., W.L. Chan, Y.C. Chen, T.J. Chen, S.J. Lin, J.W. Chen and H.B. Leu, 2011. Angiotensin II receptor blockers and risk of cancer in patients with systemic hypertension. Am. J. Cardiol., 107: 1028-1033.
    CrossRef  |  PubMed  |  Direct Link  |  
  29. Huang, C.C., W.L. Chan, Y.C. Chen, T.J. Chen and K.T. Chou et al., 2011. Statin use in patients with asthma - a nationwide population-based study. Eur. J. Clin. Invest., 41: 507-512.
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  30. Ho, S.J., A.N. Feng, L.N. Lee, J.W. Chen and S.J. Lin, 2011. Predictive value of predischarge spectral tissue doppler echocardiography and n-terminal pro-b-type natriuretic peptide in patients hospitalized with acute heart failure. Echocardiography, 28: 303-310.
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  31. Chen, J.S., P.H. Huang, C.H. Wang, F.Y. Lin and H.Y. Tsai et al., 2011. Nrf-2 mediated heme oxygenase-1 expression, an antioxidant-independent mechanism, contributes to anti-atherogenesis and vascular protective effects of Ginkgo biloba extract. Atherosclerosis, 214: 301-309.
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  32. Wu, C.C., S.C. Wen, C.W. Yang, S.Y. Pu, K.C. Tsai and J.W. Chen, 2010. Baseline plasma glycemic profiles but not inflammatory biomarkers predict symptomatic restenosis after angioplasty of arteriovenous fistulas in patients with hemodialysis. Atherosclerosis, 209: 598-600.
    CrossRef  |  PubMed  |  Direct Link  |  
  33. Huang, S.S., P.H. Huang, H.B. Leu, T.C. Wu, S.J. Lin and J.W. Chen, 2010. Serum bilirubin predicts long-term clinical outcomes in patients with cardiac syndrome X. Heart, 96: 1227-1732.
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  34. Huang, P.H., Y.H. Chen, H.Y. Tsai, J.S. Chen and T.C. Wu et al., 2010. Intake of red wine increases the number and functional capacity of circulating endothelial progenitor cells by enhancing nitric oxide bioavailability. Arteriosclerosis Thrombosis Vascular Biol., 30: 869-877.
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  35. Huang, P.H., S.S. Huang, Y.H. Chen, C.P. Lin and K.H. Chiang et al., 2010. Increased circulating CD31+/annexin V+ apoptotic microparticles and decreased circulating endothelial progenitor cell levels in hypertensive patients with microalbuminuria. J. Hypertens, 28: 1655-1665.
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  36. Huang, P.H., H.Y. Tsai, C.H. Wang, Y.H. Chen and J.S. Chen et al., 2010. Moderate intake of red wine improves ischemia-induced neovascularization in diabetic mice-Roles of endothelial progenitor cells and nitric oxide. Atherosclerosis, 212: 426-435.
    CrossRef  |  PubMed  |  Direct Link  |  
  37. Huang, C.C., Y.C. Chen, H.B. Leu, T.J. Chen, S.J. Lin, W.L. Chan and J.W. Chen, 2010. Risk of adverse outcomes in Taiwan associated with concomitant use of clopidogrel and proton pump inhibitors in patients who received percutaneous coronary intervention. Am. J. Cardiol., 105: 1705-1709.
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  38. Huang, C.C., T.C. Wu, S.J. Lin, J.W. Chen and H.B. Leu, 2010. Clinical predictors of significant white-coat effect in non-diabetic hypertensive patients. Acta Cardiol. Sin., 26: 151-156.
  39. Huang, C.C., C.Y. Chan, C.L. Wu, Y.L. Chen and H.W. Yang et al., 2010. Assessment of clinical competence of medical students using the objective structured clinical examination: First 2 years' experience in Taipei Veterans General Hospital. J. Chin Med. Assoc., 73: 589-595.
    CrossRef  |  PubMed  |  Direct Link  |  
  40. Fong, M.C., C.C. Huang, H.B. Leu, T.C. Wu, S.J. Lin and J.W. Chen, 2010. Glucose and non-glucose predictors of future onset of type 2 diabetes in newly diagnosed essential hypertensives. J. Chinese Med. Assoc., 72: 564-572.
    CrossRef  |  PubMed  |  Direct Link  |  
  41. Chung, C.M., R.Y. Wang, J.W. Chen, C.S.J. Fann and H.B. Leu et al., 2010. A genome-wide association study identifies new loci for ACE activity: potential implications for response to ACE inhibitor. Pharmacogenomics J., 10: 537-544.
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  42. Chiang, C.H., C.C. Huang, W.L. Chan, J.W. Chen and H.B. Leu, 2010. The severity of non-alcoholic fatty liver disease correlates with high sensitivity C-reactive protein value and is independently associated with increased cardiovascular risk in healthy population. Clin. Biochem., 43: 1399-1404.
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  43. Cheng, H.M., K.L. Wang, Y.H. Chen, S.J. Lin and L.C. Chen et al., 2010. Estimation of central systolic blood pressure using an oscillometric blood pressure monitor. Hypertens Res., 33: 592-599.
    CrossRef  |  PubMed  |  Direct Link  |  
  44. Yang, H.C., Y.J. Liang, Y.L. Wu, K.M. Chiang and H.Y. Ho et al., 2009. Genome-wide association study of young-onset hypertension in the Han Chinese population of Taiwan. PLoS ONE, 4: e5459-e5459.
    CrossRef  |  PubMed  |  Direct Link  |  
  45. Wu, C.C., S.C. Wen, C.W. Yang, S.Y. Pu, K.C. Tsai and J.W. Chen, 2009. Plasma ADMA predicts restenosis of arteriovenous fistula. J. Am. Soc. Nephro., 20: 213-222.
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  46. Lin, C.P., Y.H. Chen, H.B. Leu, S.J. Lin, Y.L. Chen, S.L. Huang and J.W. Chen, 2009. Anti-inflammatory strategies for homocysteine-related cardiovascular disease. Front Biosci., 14: 3836-3845.
    PubMed  |  
  47. Leu, H.B., W.T. Lin, C.P. Lin, T.C. Wu, S.J. Lin and J.W. Chen, 2009. Predictors of inexplicable coronary artery spasm during coronary angiography in patients with stable angina - the role of intravascular oxidative stress. Clin. Biochem., 42: 570-577.
    CrossRef  |  PubMed  |  Direct Link  |  
  48. Huang, W.P., W.H. Yin, J.W. Chen, H.L. Jen, M.S. Young and S.J. Lin, 2009. Fenofibrate attenuates endothelial monocyte adhesion in chronic heart failure: An in vitro study. Eur. J. Clin. Invest. 39: 775-783.
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  49. Huang, S.S., T.C. Wu, S.J. Lin and J.W. Chen, 2009. Combination of an ACE inhibitor and indapamide improves blood pressure control, but attenuates the beneficial effects of ACE inhibition on plasma adiponectin in patients with essential hypertension. Circ. J., 73: 2282-2287.
    CrossRef  |  PubMed  |  Direct Link  |  
  50. Huang, P.H., Y.H. Chen, C.H. Wang, J.S. Chen and H.Y. Tsai et al., 2009. Matrix metalloproteinase-9 is essential for ischemia-induced neovascularization by modulating bone marrow-derived endothelial progenitor cells. Arteriosclerosis Thrombosis Vascular Biol., 29: 1179-1184.
    CrossRef  |  PubMed  |  Direct Link  |  
  51. Huang, C.C., H.B. Leu, T.C. Wu, S.J. Lin and J.W. Chen, 2009. Circadian variation of blood pressure is correlated to vascular endothelial function in nondiabetic essential hypertensives. Acta Cardiol. Sinica, 25: 134-141.
    Direct Link  |  
  52. Chiang, K.H., P.H. Huang, S.S. Huang, T.C. Wu, J.W. Chen and S.J. Lin, 2009. Plasma levels of soluble receptor for advanced glycation end products are associated with endothelial function and predict cardiovascular events in nondiabetic patients. Coron Artery Dis., 20: 267-273.
    CrossRef  |  PubMed  |  Direct Link  |  
  53. Chen, P., Y.S. Jou, C.S. Fann, J.W. Chen and C.M. Chung et al., 2009. Lipoprotein lipase variants associated with an endophenotype of hypertension: hypertension combined with elevated triglycerides. Human Mutat., 30: 49-55.
    CrossRef  |  PubMed  |  Direct Link  |  
  54. Wu, T.C., Y.H. Chen, J.W. Chen, L.C. Chen and S.J. Lin et al., 2000. Impaired forearm reactive hyperemia is related to late restenosis after coronary stenting. Am. J. Cardiol., 85: 1071-1076.
    PubMed  |  Direct Link  |  
  55. Chen, Y.H., J.W. Chen, T.C. Wu, Y.A. Ding, S.P. Wang and M.S. Chang, 2000. Safety and efficacy of the platelet glycoprotein IIb/IIIa inhibitor abciximab in Chinese patients undergoing high-risk angioplasty. Chin Med. J. (Taipei), 63: 8-15.
    PubMed  |