Dr. Engin  Ulukaya

Dr. Engin Ulukaya

Lecturer
Uludag University, Turkey


Highest Degree
Ph.D. in Biochemistry and Molecular Biology from University of Leeds, UK

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Area of Interest:

Biomedical Sciences
100%
Biochemistry
62%
Oncology
90%
Malignant Cells
75%
Anticancer Drugs
55%

Education

2006

Ph.D.

University of Leeds, UK

Biochemistry and Molecular Biology

Selected Publications

  1. Ulukaya, E., F.M. Frame, B. Cevatemre, D. Pellacani and H. Walker et al., 2013. Differential cytotoxic activity of a novel palladium-based compound on prostate cell lines, primary prostate epithelial cells and prostate stem cells. Plos ONE, Vol. 8. 10.1371/journal.pone.0064278.
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  2. Sahin, S., F. Ari, C. Demir and E. Ulukaya, 2013. Isolation of major phenolic compounds from the extracts of Prunella L. species grown in Turkey and their antioxidant and cytotoxic activities. J. Food Biochem., 10.1111/jfbc.12043.
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  3. Icsel, C., V.T. Yilmaz, F. Ari, E. Ulukaya and W.T. Harrison, 2013. trans-Dichloridopalladium(II) and platinum(II) complexes with 2-(hydroxymethyl)pyridine and 2-(2-hydroxyethyl)pyridine: Synthesis, structural characterization, DNA binding and in vitro cytotoxicity studies. Eur. J. Med. Chem., 60: 386-394.
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  4. Icsel, C., V.T. Yilmaz, A. Golcu, E. Ulukaya and O. Buyukgungor, 2013. Synthesis, crystal structures, DNA binding and cytotoxicity of two novel platinum(II) complexes containing 2-(hydroxymethyl)pyridine and pyridine-2-carboxylate ligands. Bioorganic Med. Chem. Lett., 23: 2117-2122.
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  5. Coskun, M.D., F. Ari, A.Y. Oral, M. Sarimahmut, H.M. Kutlu, V.T. Yilmaz and E. Ulukaya, 2013. Promising anti-growth effects of palladium(II) saccharinate complex of terpyridine by inducing apoptosis on transformed fibroblasts in vitro. Bioorganic Med. Chem., 21: 4698-4705.
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  6. Cevatemre, B., F. Ari, M. Sarimahmut, A.O. Yilmaztepe and E. Dere et al., 2013. Combination of fenretinide and indole-3-carbinol results in synergistic cytotoxic activity inducing apoptosis against human breast cancer cells in vitro. Anticancer Drugs, 24: 577-586.
    CrossRef  |  PubMed  |  

  7. Ari, F., R. Napieralski and E. Ulukaya, 2013. Changes in gene methylation following chemotherapy in breast cancer cell lines. Turk. J. Biochem., 38: 34-42.
    Direct Link  |  

  8. Ari, F., N. Aztopal, C. Icsel, V.T. Yilmaz, E. Guney and E. Ulukaya, 2013. Synthesis, structural characterization and cell death-inducing effect of novel palladium(II) and platinum(II) saccharinate complexes with 2-(hydroxymethyl)pyridine and 2-(2-hydroxyethyl)pyridine on cancer cells in vitro. Bioorganic Med. Chem., 21: 6427-6434.
    CrossRef  |  PubMed  |  Direct Link  |  

  9. Ari, F., E. Ulukaya, M. Sarimahmut and V.T. Yilmaz, 2013. Palladium(II) saccharinate complexes with bis(2-pyridylmethyl)amine induce cell death by apoptosis in human breast cancer cells in vitro. Bioorganic Med. Chem., 21: 3016-3021.
    CrossRef  |  PubMed  |  Direct Link  |  

  10. Akdag, M.Z., S. Dasdag, A.K. Uzunlar, E. Ulukaya, A.Y. Oral, N. Celik and F. Aksen, 2013. Can safe and long-term exposure to extremely low frequency (50 Hz) magnetic fields affect apoptosis, reproduction and oxidative stress. Int. J. Radiat. Biol., 10.3109/09553002.2013.817705.
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  11. Yerlikaya, A., E. Okur and E. Ulukaya, 2012. The p53-independent induction of apoptosis in breast cancer cells in response to proteasome inhibitor bortezomib. Tumour Biol., 33: 1385-1392.
    CrossRef  |  PubMed  |  Direct Link  |  

  12. Tsimplouli, C., P. Pantazis, K. Alevizopoulos, E. Ulukaya and K. Dimas, 2012. Patient-Derived Xenografts: Real-Time Modeling of Cancer. In: Advances in Medicine and Biology, Berhardt, L.V. (Ed.). Nova Science Publishers, New York, USA.

  13. Daidone, M.G., J.A. Foekens, N. Harbeck, J. Martens and N. Brunner et al., 2012. Identification, validation and clinical implementation of cancer biomarkers: Translational strategies of the EORTC PathoBiology Group. Eur. J. Cancer Suppl., 10: 120-127.
    CrossRef  |  Direct Link  |  

  14. Bozcuk, H., H. Abali, S. Coskun and Lung Cancer Committee of Turkish Oncology Group, 2012. The correlates of benefit from neoadjuvant chemotherapy before surgery in non-small-cell lung cancer: A metaregression analysis. World J. Surg. Oncol., Vol. 10. 10.1186/1477-7819-10-161.
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  15. Ari, F., S. Celikler, S. Oran, N. Balikci and S. Ozturk et al., 2012. Genotoxic, cytotoxic and apoptotic effects of Hypogymnia physodes (L.) Nyl. on breast cancer cells. Environ. Toxicol., 10.1002/tox.21809.
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  16. Ari, F., M. Sarimahmut and E. Ulukaya, 2012. Peripherally located A431 cells are more sensitive to cell death induced by exogenous oxidative stress. Curr. Signal Transduct. Ther., 7: 202-208.

  17. Yilmaz, Y., O. Yonal, R. Kurt, Y.O. Alandab and O. Ozdogan et al., 2011. Circulating levels of vascular endothelial growth factor a and ıts soluble receptor in patients with biopsy-proven nonalcoholic fatty liver disease. Arch. Med. Res., 42: 38-43.
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  18. Yilmaz, Y. and E. Ulukaya, 2011. Toward a biochemical diagnosis of NASH: Insights from pathophysiology for distinguishing simple steatosis from steatohepatitis. Curr. Med. Chem., 18: 725-732.
    CrossRef  |  PubMed  |  

  19. Ulukaya, E., F. Ari, K. Dimas, M. Sarimahmut, E. Guney, N. Sakellaridis and V.T. Yilmaz, 2011. Cell death-inducing effect of novel palladium(II) and platinum(II) complexes on non-small cell lung cancer cells in vitro. J. Cancer Res. Clin. Oncol., 137: 1425-1434.
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  20. Ulukaya, E., F. Ari, K. Dimas, E.I. Ikitimur, E. Guney and V.T. Yilmaz, 2011. Anti-cancer activity of a novel palladium(II) complex on human breast cancer cells in vitro and in vivo. Eur. J. Med. Chem., 46: 4957-4963.
    CrossRef  |  PubMed  |  Direct Link  |  

  21. Ulukaya, E., E. Karaagac, F. Ari, A.Y. Oral, S.B. Adim, A.H. Tokullugil and T. Evrensel, 2011. Chemotherapy ıncreases caspase-cleaved cytokeratin 18 in the serum of breast cancer patients. Radiol. Oncol., 45: 116-122.
    CrossRef  |  PubMed  |  

  22. Ulukaya, E., C. Acilan, F. Ari, E. Ikitimur and Y. Yilmaz, 2011. A glance at the methods for detection of apoptosis qualitatively and quantitatively. Turk. J. Biochem., 36: 261-269.
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  23. Ulukaya, E., C. Acilan and Y. Yilmaz, 2011. Apoptosis: Why and how does it occur in biology? Cell Biochem. Funct., 29: 468-480.
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  24. Ulukaya, E., A. Yagci, B. Zik, A.Sevimli and O.A. Yilmaztepe et al., 2011. The expressions of pAkt and PTEN in lung cancer patients 24 hours after the cisplatin-based chemotherapy: A prospective pilot study. Int. J. Hematol. Oncol., 21: 26-33.
    Direct Link  |  

  25. Guney, E., V.T. Yilmaz, F. Ari, O. Buyukgungor and E. Ulukaya, 2011. Synthesis, characterization, structures and cytotoxic activity of palladium(II) and platinum(II) complexes containing bis(2-pyridylmethyl)amine and saccharinate. Polyhedron, 30: 114-122.
    CrossRef  |  Direct Link  |  

  26. Ari, F., R. Napieralski, E. Ulukaya, E. Dere and C. Colling et al., 2011. Modulation of protein expression levels and DNA methylation status of breast cancer metastasis genes by anthracycline-based chemotherapy and the demethylating agent decitabine. Cell Biochem. Funct., 29: 651-659.
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  27. Yilmaz, Y., O. Yonal, R. Kurt, F. Ari and A.Y. Oral et al., 2010. Serum fetuin A/alpha 2HS-glycoprotein levels in patients with non-alcoholic fatty liver disease: Relation with liver fibrosis. Ann. Clin. Biochem., 47: 549-553.

  28. Yilmaz, Y., O. Yonal, R. Kurt, A.Y. Oral and F. Eren et al., 2010. Serum levels of osteoprotegerin in the spectrum of nonalcoholic fatty liver disease. Scandınavıan J. Clin. Lab. Invest., 70: 541-546.
    CrossRef  |  PubMed  |  Direct Link  |  

  29. Yilmaz, Y. and E. Ulukaya, 2010. Molecular signatures of nonalcoholic fatty liver disease: The present and future. Hepatology, 51: 1866-1866.
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  30. Ulukaya, S., E. Ulukaya, I. Alper, A. Yilmaztepe-Oral and M. Kilic, 2010. Soluble cytokeratin 18 biomarkers may provide information on the type of cell death during early ischemia and reperfusion periods of liver transplantation. Clin. Transplant., 24: 848-854.
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  31. Ulukaya, E., C. Acilan, M. Yilmaz, A. Yilmaztepe-Oral and F. Ari et al., 2010. sFas levels increase in response to cisplatin-based chemotherapy in lung cancer patients. Cell Biochem. Funct., 28: 565-570.
    CrossRef  |  Direct Link  |  

  32. Linder, S., M.H. Olofsson, R. Herrmann and E. Ulukaya, 2010. Utilization of cytokeratin-based biomarkers for pharmacodynamic studies. Expert Rev. Mol. Diagn., 10: 353-359.
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  33. Gul, O.O., E. Tuncel, Y. Yilmaz, E. Ulukaya and C.B. Gul et al., 2010. Comparative effects of pioglitazone and rosiglitazone on plasma levels of soluble receptor for advanced glycation end products in type 2 diabetes patients. Metab. Clin. Exp., 59: 64-69.
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  34. Ari, F., E.I. Ikitimur and E. Ulukaya, 2010. The ATP assay, but not the MTT assay, detects further cytotoxicity of the combination of anthracyline-based therapy with histone deacetylase inhibitor (Valproic acid) in breast cancer cells. Turk. J. Biochem., 35: 293-299.

  35. Akdag, M.Z., S. Dasdag, E. Ulukaya, A.K. Uzunlar, M.A. Kurt and A. Taskin, 2010. Effects of extremely low-frequency magnetic field on caspase activities and oxidative stress values in rat brain. Biol. Trace. Elem. Res., 138: 238-249.
    CrossRef  |  PubMed  |  Direct Link  |  

  36. Yilmaz, Y., E. Ulukaya, O.O. Gul, M. Arabul and C.B. Gul et al., 2009. Decreased plasma levels of soluble receptor for advanced glycation endproducts (sRAGE) in patients with nonalcoholic fatty liver disease. Clin. Biochem., 42: 802-807.
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  37. Yilmaz, Y., E. Ulukaya, O. Atug and E. Dolar, 2009. Serum concentrations of human angiopoietin-like protein 3 in patients with nonalcoholic fatty liver disease: Association with insulin resistance. Eur. J. Gastroenterol. Hepatol., 21: 1247-1251.
    CrossRef  |  PubMed  |  

  38. Yilmaz, Y., E. Ulukaya and E. Dolar, 2009. The quest for liver fibrosis biomarkers: Promises from the enhanced liver fibrosis panel and beyond. Hepatology, 49: 1056-1057.
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  39. Yilmaz, Y., E. Ulukaya and E. Dolar, 2009. Serum M30 levels: A potential biomarker of severe liver disease in nonalcoholic fatty liver disease and normal aminotransferase levels. Hepatology, 49: 697-697.
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  40. Yilmaz, Y., E. Dolar, E. Ulukaya, S. Akgoz and M. Keskin et al., 2009. Elevated serum levels of caspase-cleaved cytokeratin 18 (CK18-Asp396) in patients with nonalcoholic steatohepatitis and chronic hepatitis C. Med. Sci. Monit., 15: 189-193.
    PubMed  |  Direct Link  |  

  41. Yilmaz, Y., E. Dolar and E. Ulukaya, 2009. Commentary on the study of Vos et al. Cytokeratin 18, a marker of cell death, is increased in children with suspected nonalcoholic fatty liver disease. J. Pediatr. Gastroenterol. Nutr., 49: 371-371.
    PubMed  |  

  42. Ulukaya, E., Y. Yilmaz, S. Moshkovskii, M. Vlaslova, M. Pyatnitskiy, A. Ozlen and E. Dolar, 2009. Proteomic analysis of serum in patients with non-alcoholic steatohepatitis using matrix-assisted laser desorption ionization time-of-flight mass spectrometry. Scandinavian J. Gastroenterol., 44: 1471-1476.
    Direct Link  |  

  43. Taskin, E.I., K. Akgun-Dar, A. Kapucu, E. Osanc, H. Dogruman, H. Eraltan and E. Ulukaya, 2009. Apoptosis-inducing effects of Morinda citrifolia L. and doxorubicin on the Ehrlich ascites tumor in Balb-c mice. Cell Biochem. Funct., 27: 542-546.
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  44. Senturk, T., A. Aydinlar, Y. Yilmaz, A.Y. Oral, O. Ozdabakoglu and E. Ulukaya, 2009. Serial changes in circulating M30 antigen, a biomarker of apoptosis, in patients with acute coronary syndromes: Relationship with the severity of coronary artery disease. Coron Artery Dis., 20: 494-498.
    CrossRef  |  PubMed  |  

  45. Dasdag, S., M.Z. Akdag, E. Ulukaya, A.K. Uzunlar and A.R. Ocak, 2009. Effect of mobile phone exposure on apoptotic glial cells and status of oxidative stress in rat brain. Electromagn. Biol. Med., 28: 342-354.
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  46. Yilmaz, Y., E. Ulukaya and E. Dolar, 2008. A biomarker biopsy for the diagnosis of NASH: Promises from CK-18 fragments. Obessity Surg., 18: 1507-1508.
    CrossRef  |  Direct Link  |  

  47. Ulukaya, S., B. Basturk, M. Kilic and E. Ulukaya, 2008. Cytokine gene polymorphism and postreperfusion syndrome during orthotopic liver transplantation. Transplant. Proc., 40: 1290-1293.
    CrossRef  |  PubMed  |  Direct Link  |  

  48. Ulukaya, E., F. Ozdikicioglu, A.Y. Oral and M. Demirci, 2008. The MTT assay yields a relatively lower result of growth inhibition than the ATP assay depending on the chemotherapeutic drugs tested. Toxicol. In Vitro, 22: 232-239.
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  49. Kaya, H., R. Desdicioglu, M. Sezik, E. Ulukaya, O. Ozkaya, A. Yilmaztepe and M. Demirci, 2008. Does sphingosine-1-phosphate have a protective effect on cyclophosphamide- and irradiation-induced ovarian damage in the rat model? Fertil. Steril., 89: 732-735.
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  50. Dasdag, S., M.Z. Akdag, E. Ulukaya, A.K. Uzunlar and D. Yegin, 2008. Mobile phone exposure does not induce apoptosis on spermatogenesis in rats. Arch. Med. Res., 39: 40-44.
    CrossRef  |  PubMed  |  Direct Link  |  

  51. Colakogullari, M., E. Ulukaya, A.Yilmaztepe, F. Aymak, B. Basturk, A. Ursavas and H.B. Oral, 2008. The involvement of IL-10, IL-6, IFN-γ, TNF-α and TGF-β gene polymorphisms among Turkish lung cancer patients. Cell Biochem. Funct., 26: 283-290.
    CrossRef  |  PubMed  |  Direct Link  |  

  52. Yilmaztepe, O.A., E. Ulukaya and Y. Yilmaz, 2007. VEGF, VEGF-receptors and lung cancer. Adv. Mol. Med., 3: 15-21.

  53. Yilmaztepe, A., E. Ulukaya, B. Zik, A. Yagci and A. Sevimli et al., 2007. Soluble vascular endothelial growth factor receptor-1 (sVEGFR-1) is decreased in lung cancer patients showing progression: A pilot study. Cancer Invest., 25: 322-327.
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  54. Yilmaz, Y., E. Dolar, E. Ulukaya, S. Akgoz and M. Keskin et al., 2007. Soluble forms of extracellular cytokeratin 18 may differentiate simple steatosis from nonalcoholic steatohepatitis. World J. Gastroenterol., 13: 837-844.
    PubMed  |  Direct Link  |  

  55. Ulukaya, E., A. Yilmaztepe, S. Akgoz, S. Linder and M. Karadag, 2007. The levels of caspase-cleaved cytokeratin 18 are elevated in serum from patients with lung cancer and helpful to predict the survival. Lung Cancer, 56: 399-404.
    CrossRef  |  PubMed  |  Direct Link  |  

  56. Ozdikicioglu, F., E. Ulukaya, A.Y. Oral, M.Z. Ozel and O. Kutlular, 2007. The differential anticancer effects of green tea in estrogen receptor-positive and estrogen receptor-negative human breast cancer cell lines. Adv. Mol. Med., 3: 69-75.
    CrossRef  |  Direct Link  |  

  57. Akkaya, O., M. Kiyici, Y. Yilmaz, E. Ulukaya and O. Yerci, 2007. Clinical significance of activity of ALT enzyme in patients with hepatitis C virus. World J. Gastroenterol., 13: 5481-5485.
    PubMed  |  Direct Link  |  

  58. Demiray, M., E.E. Ulukaya, M. Arslan, S. Gokgoz and O. Saraydaroglu et al., 2006. Response to neoadjuvant chemotherapy in breast cancer could be predictable by measuring a novel serum apoptosis product, caspase-cleaved cytokeratin 18: A prospective pilot study. Cancer Invest., 24: 669-676.
    CrossRef  |  PubMed  |  Direct Link  |  

  59. Colakogullari, M., E. Ulukaya, A. Yilmaztepe, G. Ocakoglu, M. Yilmaz, M. Karadag and A. Tokullugil, 2006. Higher serum nitrate levels are associated with poor survival in lung cancer patients. Clin. Biochem., 39: 898-903.
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  60. Kaya, H., O. Ozkaya, M. Sezik, E. Arslanoglu, A. Yilmaztepe and E. Ulukaya, 2005. Effects of raloxifene on serum malondialdehyde, erythrocyte superoxide dismutase, and erythrocyte glutathione peroxidase levels in healthy postmenopausal women. Maturitas, 50: 182-188.
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  61. Ulukaya, E., M. Colakogullari and E.J. Wood, 2004. Interference by anti-cancer chemotherapeutic agents in the MTT-tumor chemosensitivity assay. Chemotherapy, 50: 43-50.
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  62. Karasu, Z., S. Ulukaya, H.O. Ayanoglu, B. Basturk, E. Ulukaya, M. Akyildiz and Y. Tokat, 2004. Cytokine gene polymorphism and early graft rejection in liver transplant recipients. Transplant. Proc., 36: 2791-2795.
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  63. Demiray, M., M. Gulten, O. Manavoglu, T. Evrensel and E. Ulukaya et al., 2004. Evaluation of the effects of helicobacter pylori eradication therapy on gastric antral epithelial hyperproliferation: A prospective, sixth-month follow-up study. Hepatogastroenterology, 51: 1531-1535.

  64. Ulukaya, E., G. Pirianov, M.A. Kurt, E.J. Wood and H. Mehmet, 2003. Fenretinide induces cytochrome c release, caspase 9 activation and apoptosis in the absence of mitochondrial membrane depolarisation. Cell Death Differ., 10: 856-859.
    CrossRef  |  PubMed  |  Direct Link  |  

  65. Ulukaya, E., A. Kurt and E.J. Wood, 2001. 4-(N-Hydroxyphenyl)retinamide can selectively ınduces apoptosis in human epidermoid carcinoma cells but not in normal dermal fibroblasts. Cancer Investigation, 19: 1-12.

  66. Ulukaya, E. and E.J. Wood, 1999. Fenretinide and its relation to cancer. Cancer Treat. Rev., 25: 229-235.
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  67. Kaya, H., N. Delibas, M. Serteser, E. Ulukaya and O. Ozkaya, 1999. The effect of melatonin on lipid peroxidation during radiotherapy in female rats. Strahlentherapie Onkologie, 175: 285-288.
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