Hi, I am Engin Ulukaya, My LiveDNA is 90.5961
 
   
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Dr. Engin Ulukaya
 
Highest Degree: Ph.D. in Biochemistry and Molecular Biology from University of Leeds, UK
 
Institute: Uludag University, Turkey
 
Area of Interest: Biomedical Sciences
  •   Tumor Chemosensitivity Assay
  •   Oncology
  •   Malignant Cells
  •   Anticancer Drugs
 
URL: http://livedna.org/90.5961
 
My SELECTED Publications
1:   Akdag, M.Z., S. Dasdag, A.K. Uzunlar, E. Ulukaya, A.Y. Oral, N. Celik and F. Aksen, 2013. Can safe and long-term exposure to extremely low frequency (50 Hz) magnetic fields affect apoptosis, reproduction and oxidative stress. Int. J. Radiat. Biol., 10.3109/09553002.2013.817705.
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2:   Akdag, M.Z., S. Dasdag, E. Ulukaya, A.K. Uzunlar, M.A. Kurt and A. Taskin, 2010. Effects of extremely low-frequency magnetic field on caspase activities and oxidative stress values in rat brain. Biol. Trace. Elem. Res., 138: 238-249.
CrossRef  |  PubMed  |  Direct Link  |  
3:   Akkaya, O., M. Kiyici, Y. Yilmaz, E. Ulukaya and O. Yerci, 2007. Clinical significance of activity of ALT enzyme in patients with hepatitis C virus. World J. Gastroenterol., 13: 5481-5485.
PubMed  |  Direct Link  |  
4:   Ari, F., E. Ulukaya, M. Sarimahmut and V.T. Yilmaz, 2013. Palladium(II) saccharinate complexes with bis(2-pyridylmethyl)amine induce cell death by apoptosis in human breast cancer cells in vitro. Bioorganic Med. Chem., 21: 3016-3021.
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5:   Ari, F., E.I. Ikitimur and E. Ulukaya, 2010. The ATP assay, but not the MTT assay, detects further cytotoxicity of the combination of anthracyline-based therapy with histone deacetylase inhibitor (Valproic acid) in breast cancer cells. Turk. J. Biochem., 35: 293-299.
6:   Ari, F., M. Sarimahmut and E. Ulukaya, 2012. Peripherally located A431 cells are more sensitive to cell death induced by exogenous oxidative stress. Curr. Signal Transduct. Ther., 7: 202-208.
7:   Ari, F., N. Aztopal, C. Icsel, V.T. Yilmaz, E. Guney and E. Ulukaya, 2013. Synthesis, structural characterization and cell death-inducing effect of novel palladium(II) and platinum(II) saccharinate complexes with 2-(hydroxymethyl)pyridine and 2-(2-hydroxyethyl)pyridine on cancer cells in vitro. Bioorganic Med. Chem., 21: 6427-6434.
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8:   Ari, F., R. Napieralski and E. Ulukaya, 2013. Changes in gene methylation following chemotherapy in breast cancer cell lines. Turk. J. Biochem., 38: 34-42.
Direct Link  |  
9:   Ari, F., R. Napieralski, E. Ulukaya, E. Dere and C. Colling et al., 2011. Modulation of protein expression levels and DNA methylation status of breast cancer metastasis genes by anthracycline-based chemotherapy and the demethylating agent decitabine. Cell Biochem. Funct., 29: 651-659.
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10:   Ari, F., S. Celikler, S. Oran, N. Balikci and S. Ozturk et al., 2012. Genotoxic, cytotoxic and apoptotic effects of Hypogymnia physodes (L.) Nyl. on breast cancer cells. Environ. Toxicol., 10.1002/tox.21809.
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11:   Bozcuk, H., H. Abali, S. Coskun and Lung Cancer Committee of Turkish Oncology Group, 2012. The correlates of benefit from neoadjuvant chemotherapy before surgery in non-small-cell lung cancer: A metaregression analysis. World J. Surg. Oncol., Vol. 10. 10.1186/1477-7819-10-161.
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12:   Cevatemre, B., F. Ari, M. Sarimahmut, A.O. Yilmaztepe and E. Dere et al., 2013. Combination of fenretinide and indole-3-carbinol results in synergistic cytotoxic activity inducing apoptosis against human breast cancer cells in vitro. Anticancer Drugs, 24: 577-586.
CrossRef  |  PubMed  |  
13:   Colakogullari, M., E. Ulukaya, A. Yilmaztepe, G. Ocakoglu, M. Yilmaz, M. Karadag and A. Tokullugil, 2006. Higher serum nitrate levels are associated with poor survival in lung cancer patients. Clin. Biochem., 39: 898-903.
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14:   Colakogullari, M., E. Ulukaya, A.Yilmaztepe, F. Aymak, B. Basturk, A. Ursavas and H.B. Oral, 2008. The involvement of IL-10, IL-6, IFN-γ, TNF-α and TGF-β gene polymorphisms among Turkish lung cancer patients. Cell Biochem. Funct., 26: 283-290.
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15:   Coskun, M.D., F. Ari, A.Y. Oral, M. Sarimahmut, H.M. Kutlu, V.T. Yilmaz and E. Ulukaya, 2013. Promising anti-growth effects of palladium(II) saccharinate complex of terpyridine by inducing apoptosis on transformed fibroblasts in vitro. Bioorganic Med. Chem., 21: 4698-4705.
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16:   Daidone, M.G., J.A. Foekens, N. Harbeck, J. Martens and N. Brunner et al., 2012. Identification, validation and clinical implementation of cancer biomarkers: Translational strategies of the EORTC PathoBiology Group. Eur. J. Cancer Suppl., 10: 120-127.
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17:   Dasdag, S., M.Z. Akdag, E. Ulukaya, A.K. Uzunlar and A.R. Ocak, 2009. Effect of mobile phone exposure on apoptotic glial cells and status of oxidative stress in rat brain. Electromagn. Biol. Med., 28: 342-354.
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18:   Dasdag, S., M.Z. Akdag, E. Ulukaya, A.K. Uzunlar and D. Yegin, 2008. Mobile phone exposure does not induce apoptosis on spermatogenesis in rats. Arch. Med. Res., 39: 40-44.
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19:   Demiray, M., E.E. Ulukaya, M. Arslan, S. Gokgoz and O. Saraydaroglu et al., 2006. Response to neoadjuvant chemotherapy in breast cancer could be predictable by measuring a novel serum apoptosis product, caspase-cleaved cytokeratin 18: A prospective pilot study. Cancer Invest., 24: 669-676.
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20:   Demiray, M., M. Gulten, O. Manavoglu, T. Evrensel and E. Ulukaya et al., 2004. Evaluation of the effects of helicobacter pylori eradication therapy on gastric antral epithelial hyperproliferation: A prospective, sixth-month follow-up study. Hepatogastroenterology, 51: 1531-1535.
21:   Gul, O.O., E. Tuncel, Y. Yilmaz, E. Ulukaya and C.B. Gul et al., 2010. Comparative effects of pioglitazone and rosiglitazone on plasma levels of soluble receptor for advanced glycation end products in type 2 diabetes patients. Metab. Clin. Exp., 59: 64-69.
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22:   Guney, E., V.T. Yilmaz, F. Ari, O. Buyukgungor and E. Ulukaya, 2011. Synthesis, characterization, structures and cytotoxic activity of palladium(II) and platinum(II) complexes containing bis(2-pyridylmethyl)amine and saccharinate. Polyhedron, 30: 114-122.
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23:   Icsel, C., V.T. Yilmaz, A. Golcu, E. Ulukaya and O. Buyukgungor, 2013. Synthesis, crystal structures, DNA binding and cytotoxicity of two novel platinum(II) complexes containing 2-(hydroxymethyl)pyridine and pyridine-2-carboxylate ligands. Bioorganic Med. Chem. Lett., 23: 2117-2122.
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24:   Icsel, C., V.T. Yilmaz, F. Ari, E. Ulukaya and W.T. Harrison, 2013. trans-Dichloridopalladium(II) and platinum(II) complexes with 2-(hydroxymethyl)pyridine and 2-(2-hydroxyethyl)pyridine: Synthesis, structural characterization, DNA binding and in vitro cytotoxicity studies. Eur. J. Med. Chem., 60: 386-394.
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25:   Karasu, Z., S. Ulukaya, H.O. Ayanoglu, B. Basturk, E. Ulukaya, M. Akyildiz and Y. Tokat, 2004. Cytokine gene polymorphism and early graft rejection in liver transplant recipients. Transplant. Proc., 36: 2791-2795.
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26:   Kaya, H., N. Delibas, M. Serteser, E. Ulukaya and O. Ozkaya, 1999. The effect of melatonin on lipid peroxidation during radiotherapy in female rats. Strahlentherapie Onkologie, 175: 285-288.
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27:   Kaya, H., O. Ozkaya, M. Sezik, E. Arslanoglu, A. Yilmaztepe and E. Ulukaya, 2005. Effects of raloxifene on serum malondialdehyde, erythrocyte superoxide dismutase, and erythrocyte glutathione peroxidase levels in healthy postmenopausal women. Maturitas, 50: 182-188.
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28:   Kaya, H., R. Desdicioglu, M. Sezik, E. Ulukaya, O. Ozkaya, A. Yilmaztepe and M. Demirci, 2008. Does sphingosine-1-phosphate have a protective effect on cyclophosphamide- and irradiation-induced ovarian damage in the rat model? Fertil. Steril., 89: 732-735.
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29:   Linder, S., M.H. Olofsson, R. Herrmann and E. Ulukaya, 2010. Utilization of cytokeratin-based biomarkers for pharmacodynamic studies. Expert Rev. Mol. Diagn., 10: 353-359.
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30:   Ozdikicioglu, F., E. Ulukaya, A.Y. Oral, M.Z. Ozel and O. Kutlular, 2007. The differential anticancer effects of green tea in estrogen receptor-positive and estrogen receptor-negative human breast cancer cell lines. Adv. Mol. Med., 3: 69-75.
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31:   Sahin, S., F. Ari, C. Demir and E. Ulukaya, 2013. Isolation of major phenolic compounds from the extracts of Prunella L. species grown in Turkey and their antioxidant and cytotoxic activities. J. Food Biochem., 10.1111/jfbc.12043.
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32:   Senturk, T., A. Aydinlar, Y. Yilmaz, A.Y. Oral, O. Ozdabakoglu and E. Ulukaya, 2009. Serial changes in circulating M30 antigen, a biomarker of apoptosis, in patients with acute coronary syndromes: Relationship with the severity of coronary artery disease. Coron Artery Dis., 20: 494-498.
CrossRef  |  PubMed  |  
33:   Taskin, E.I., K. Akgun-Dar, A. Kapucu, E. Osanc, H. Dogruman, H. Eraltan and E. Ulukaya, 2009. Apoptosis-inducing effects of Morinda citrifolia L. and doxorubicin on the Ehrlich ascites tumor in Balb-c mice. Cell Biochem. Funct., 27: 542-546.
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34:   Tsimplouli, C., P. Pantazis, K. Alevizopoulos, E. Ulukaya and K. Dimas, 2012. Patient-Derived Xenografts: Real-Time Modeling of Cancer. In: Advances in Medicine and Biology, Berhardt, L.V. (Ed.). Nova Science Publishers, New York, USA.
35:   Ulukaya, E. and E.J. Wood, 1999. Fenretinide and its relation to cancer. Cancer Treat. Rev., 25: 229-235.
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36:   Ulukaya, E., A. Kurt and E.J. Wood, 2001. 4-(N-Hydroxyphenyl)retinamide can selectively ınduces apoptosis in human epidermoid carcinoma cells but not in normal dermal fibroblasts. Cancer Investigation, 19: 1-12.
37:   Ulukaya, E., A. Yagci, B. Zik, A.Sevimli and O.A. Yilmaztepe et al., 2011. The expressions of pAkt and PTEN in lung cancer patients 24 hours after the cisplatin-based chemotherapy: A prospective pilot study. Int. J. Hematol. Oncol., 21: 26-33.
Direct Link  |  
38:   Ulukaya, E., A. Yilmaztepe, S. Akgoz, S. Linder and M. Karadag, 2007. The levels of caspase-cleaved cytokeratin 18 are elevated in serum from patients with lung cancer and helpful to predict the survival. Lung Cancer, 56: 399-404.
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39:   Ulukaya, E., C. Acilan and Y. Yilmaz, 2011. Apoptosis: Why and how does it occur in biology? Cell Biochem. Funct., 29: 468-480.
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40:   Ulukaya, E., C. Acilan, F. Ari, E. Ikitimur and Y. Yilmaz, 2011. A glance at the methods for detection of apoptosis qualitatively and quantitatively. Turk. J. Biochem., 36: 261-269.
Direct Link  |  
41:   Ulukaya, E., C. Acilan, M. Yilmaz, A. Yilmaztepe-Oral and F. Ari et al., 2010. sFas levels increase in response to cisplatin-based chemotherapy in lung cancer patients. Cell Biochem. Funct., 28: 565-570.
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42:   Ulukaya, E., E. Karaagac, F. Ari, A.Y. Oral, S.B. Adim, A.H. Tokullugil and T. Evrensel, 2011. Chemotherapy ıncreases caspase-cleaved cytokeratin 18 in the serum of breast cancer patients. Radiol. Oncol., 45: 116-122.
CrossRef  |  PubMed  |  
43:   Ulukaya, E., F. Ari, K. Dimas, E.I. Ikitimur, E. Guney and V.T. Yilmaz, 2011. Anti-cancer activity of a novel palladium(II) complex on human breast cancer cells in vitro and in vivo. Eur. J. Med. Chem., 46: 4957-4963.
CrossRef  |  PubMed  |  Direct Link  |  
44:   Ulukaya, E., F. Ari, K. Dimas, M. Sarimahmut, E. Guney, N. Sakellaridis and V.T. Yilmaz, 2011. Cell death-inducing effect of novel palladium(II) and platinum(II) complexes on non-small cell lung cancer cells in vitro. J. Cancer Res. Clin. Oncol., 137: 1425-1434.
CrossRef  |  PubMed  |  Direct Link  |  
45:   Ulukaya, E., F. Ozdikicioglu, A.Y. Oral and M. Demirci, 2008. The MTT assay yields a relatively lower result of growth inhibition than the ATP assay depending on the chemotherapeutic drugs tested. Toxicol. In Vitro, 22: 232-239.
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46:   Ulukaya, E., F.M. Frame, B. Cevatemre, D. Pellacani and H. Walker et al., 2013. Differential cytotoxic activity of a novel palladium-based compound on prostate cell lines, primary prostate epithelial cells and prostate stem cells. Plos ONE, Vol. 8. 10.1371/journal.pone.0064278.
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47:   Ulukaya, E., G. Pirianov, M.A. Kurt, E.J. Wood and H. Mehmet, 2003. Fenretinide induces cytochrome c release, caspase 9 activation and apoptosis in the absence of mitochondrial membrane depolarisation. Cell Death Differ., 10: 856-859.
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48:   Ulukaya, E., M. Colakogullari and E.J. Wood, 2004. Interference by anti-cancer chemotherapeutic agents in the MTT-tumor chemosensitivity assay. Chemotherapy, 50: 43-50.
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49:   Ulukaya, E., Y. Yilmaz, S. Moshkovskii, M. Vlaslova, M. Pyatnitskiy, A. Ozlen and E. Dolar, 2009. Proteomic analysis of serum in patients with non-alcoholic steatohepatitis using matrix-assisted laser desorption ionization time-of-flight mass spectrometry. Scandinavian J. Gastroenterol., 44: 1471-1476.
Direct Link  |  
50:   Ulukaya, S., B. Basturk, M. Kilic and E. Ulukaya, 2008. Cytokine gene polymorphism and postreperfusion syndrome during orthotopic liver transplantation. Transplant. Proc., 40: 1290-1293.
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51:   Ulukaya, S., E. Ulukaya, I. Alper, A. Yilmaztepe-Oral and M. Kilic, 2010. Soluble cytokeratin 18 biomarkers may provide information on the type of cell death during early ischemia and reperfusion periods of liver transplantation. Clin. Transplant., 24: 848-854.
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52:   Yerlikaya, A., E. Okur and E. Ulukaya, 2012. The p53-independent induction of apoptosis in breast cancer cells in response to proteasome inhibitor bortezomib. Tumour Biol., 33: 1385-1392.
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53:   Yilmaz, Y. and E. Ulukaya, 2010. Molecular signatures of nonalcoholic fatty liver disease: The present and future. Hepatology, 51: 1866-1866.
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54:   Yilmaz, Y. and E. Ulukaya, 2011. Toward a biochemical diagnosis of NASH: Insights from pathophysiology for distinguishing simple steatosis from steatohepatitis. Curr. Med. Chem., 18: 725-732.
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55:   Yilmaz, Y., E. Dolar and E. Ulukaya, 2009. Commentary on the study of Vos et al. Cytokeratin 18, a marker of cell death, is increased in children with suspected nonalcoholic fatty liver disease. J. Pediatr. Gastroenterol. Nutr., 49: 371-371.
56:   Yilmaz, Y., E. Dolar, E. Ulukaya, S. Akgoz and M. Keskin et al., 2007. Soluble forms of extracellular cytokeratin 18 may differentiate simple steatosis from nonalcoholic steatohepatitis. World J. Gastroenterol., 13: 837-844.
PubMed  |  Direct Link  |  
57:   Yilmaz, Y., E. Dolar, E. Ulukaya, S. Akgoz and M. Keskin et al., 2009. Elevated serum levels of caspase-cleaved cytokeratin 18 (CK18-Asp396) in patients with nonalcoholic steatohepatitis and chronic hepatitis C. Med. Sci. Monit., 15: 189-193.
PubMed  |  Direct Link  |  
58:   Yilmaz, Y., E. Ulukaya and E. Dolar, 2008. A biomarker biopsy for the diagnosis of NASH: Promises from CK-18 fragments. Obessity Surg., 18: 1507-1508.
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59:   Yilmaz, Y., E. Ulukaya and E. Dolar, 2009. Serum M30 levels: A potential biomarker of severe liver disease in nonalcoholic fatty liver disease and normal aminotransferase levels. Hepatology, 49: 697-697.
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60:   Yilmaz, Y., E. Ulukaya and E. Dolar, 2009. The quest for liver fibrosis biomarkers: Promises from the enhanced liver fibrosis panel and beyond. Hepatology, 49: 1056-1057.
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61:   Yilmaz, Y., E. Ulukaya, O. Atug and E. Dolar, 2009. Serum concentrations of human angiopoietin-like protein 3 in patients with nonalcoholic fatty liver disease: Association with insulin resistance. Eur. J. Gastroenterol. Hepatol., 21: 1247-1251.
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62:   Yilmaz, Y., E. Ulukaya, O.O. Gul, M. Arabul and C.B. Gul et al., 2009. Decreased plasma levels of soluble receptor for advanced glycation endproducts (sRAGE) in patients with nonalcoholic fatty liver disease. Clin. Biochem., 42: 802-807.
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63:   Yilmaz, Y., O. Yonal, R. Kurt, A.Y. Oral and F. Eren et al., 2010. Serum levels of osteoprotegerin in the spectrum of nonalcoholic fatty liver disease. Scandınavıan J. Clin. Lab. Invest., 70: 541-546.
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64:   Yilmaz, Y., O. Yonal, R. Kurt, F. Ari and A.Y. Oral et al., 2010. Serum fetuin A/alpha 2HS-glycoprotein levels in patients with non-alcoholic fatty liver disease: Relation with liver fibrosis. Ann. Clin. Biochem., 47: 549-553.
65:   Yilmaz, Y., O. Yonal, R. Kurt, Y.O. Alandab and O. Ozdogan et al., 2011. Circulating levels of vascular endothelial growth factor a and ıts soluble receptor in patients with biopsy-proven nonalcoholic fatty liver disease. Arch. Med. Res., 42: 38-43.
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66:   Yilmaztepe, A., E. Ulukaya, B. Zik, A. Yagci and A. Sevimli et al., 2007. Soluble vascular endothelial growth factor receptor-1 (sVEGFR-1) is decreased in lung cancer patients showing progression: A pilot study. Cancer Invest., 25: 322-327.
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67:   Yilmaztepe, O.A., E. Ulukaya and Y. Yilmaz, 2007. VEGF, VEGF-receptors and lung cancer. Adv. Mol. Med., 3: 15-21.