Hi, I am Deniz Ekinci, My LiveDNA is 90.6344
 
   
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Dr. Deniz Ekinci
 
Highest Degree: Ph.D. in Biochemistry from Ataturk University, Erzurum, Turkey
 
Institute: Ondokuz Mayis University, Turkey
 
Area of Interest: Chemistry
  •   Enzyme Purification and Characterization
  •   Organic Chemistry
  •   Gene Expression Analysis
  •   Bioorganic Chemistry
 
URL: http://livedna.org/90.6344
 
My SELECTED Publications
1:    Ekinci, D., İ. Fidan, S. Durdagi, S. Kaban and C.T. Supuran, 2012. Kinetic and in silico analyses of thiazolidin-based inhibitors of α-carbonic anhydrase isoenzymes. J. Enzyme Inhib. Med. Chem., 28: 370-374.
PubMed  |  Direct Link  |  
2:   Aksakal, E., D. Ekinci, O. Erdogan, S. Beydemir, Z. Alim and S.B. Ceyhun, 2011. Increasing stocking density causes inhibition of metabolic-antioxidant enzymes and elevates mRNA levels of heat shock protein 70 in rainbow trout. Livestock Sci., 141: 69-75.
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3:   Aksakal, E., S.B. Ceyhun, O. Erdogan and D. Ekinci, 2010. Acute and long-term genotoxicity of deltamethrin to insulin-like growth factors and growth hormone in rainbow trout. Comp. Biochem. Physiol. Part C: Toxicol. Pharmacol., 152: 451-455.
CrossRef  |  PubMed  |  Direct Link  |  
4:   Alici, H.A., D. Ekinci and S. Beydemir, 2008. Intravenous anesthetics inhibit human paraoxonase-1 (PON1) activity in vitro and in vivo. Clin. Biochem., 41: 1384-1390.
CrossRef  |  PubMed  |  Direct Link  |  
5:   Alp, C., A. Maresca, N. A. Alp, M.S. Gultekin, D. Ekinci, A. Scozzafava and C.T. Supuran, 2012. Secondary/tertiary benzenesulfonamides with inhibitory action against the cytosolic human carbonic anhydrase isoforms I and II. J. Enzyme Inhib. Med.Chem., 28: 294-298.
CrossRef  |  PubMed  |  
6:   Alp, C., D. Ekinci, M.S. Gultekin, M. Senturk, E. Sahin, O.I. Kufrevioglu, 2010. A novel and one-pot synthesis of new 1-tosyl pyrrol-2-one derivatives and analysis of carbonic anhydrase inhibitory potencies. Bioorg. Med. Chem., 18: 4468-4474.
CrossRef  |  PubMed  |  Direct Link  |  
7:   Balaydin, H.T., H. Soyut, D. Ekinci, S. Goksu, S. Beydemir, A. Menzek and E. Sahin, 2012. Synthesis and carbonic anhydrase inhibitory properties of novel bromophenols including natural products. J. Enzyme Inhibition Med. Chem., 27: 43-50.
CrossRef  |  PubMed  |  Direct Link  |  
8:   Balaydin, H.T., S. Durdagi, D. Ekinci, M. Senturk, S. Goksu and A. Menzek, 2012. Inhibition of human carbonic anhydrase isozymes I, II and VI with a series of bisphenol, methoxy and bromophenol compounds. J. Enzyme Inhibit. Med. Chem., 27: 467-475.
CrossRef  |  Direct Link  |  
9:   Cakmak, R., S. Durdagi, D. Ekinci, M. Senturk and G. Topal, 2011. Design, synthesis and biological evaluation of novel nitroaromatic compounds as potent glutathione reductase inhibitors. Bioorg. Med. Chem. Lett., 21: 5398-5402.
CrossRef  |  PubMed  |  Direct Link  |  
10:   Cankaya, M., A.M. Hernandez, M. Ciftci, S. Beydemir and H. Ozdemir et al., 2007. An analysis of expression patterns of genes encoding proteins with catalytic activities. BMC Genomics, Vol., 8. 10.1186/1471-2164-8-232.
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11:   Cavdar, H., D. Ekinci, O. Talaz, N. Saracoglu, M. Senturk and C.T. Supuran, 2012. α-Carbonic anhydrases are sulfatases with cyclic diol monosulfate esters. J. Enzyme Inhibit. Med. Chem., 27: 148-154.
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12:   Cavdar, H., O. Talaz and D. Ekinci, 2012. Synthesis of novel mono and bis-indole conduritol derivatives and their α/β-glycosidase inhibitory effects. Bioorg. Med. Chem. Lett., 22: 7499-7503.
CrossRef  |  PubMed  |  
13:   Ceyhun, S.B., E. Aksakal, D. Ekinci, O. Erdogan and S. Beydemir, 2011. Influence of cobalt and zinc exposure on mRNA expression profiles of metallothionein and cytocrome P450 in rainbow trout. Biol. Trace Element Res., 144: 781-789.
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14:   Ceyhun, S.B., M. Senterk, D. Ekinci, O. Erdogan, A. Ciltas and E.M. Kocaman, 2010. Deltamethrin attenuates antioxidant defense system and induces the expression of heat shock protein 70 in rainbow trout. Comp. Biochem. Physiol. Part C: Toxicol. Pharmacol., 152: 215-223.
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15:   Ceyhun, S.B., M. Senturk, E. Yerlikaya, O. Erdogan, O.I. Kufrevioglu and D. Ekinci, 2011. Purification and characterization of carbonic anhydrase from the teleost fish Dicentrarchus labrax (European Seabass) liver and toxicological effects of metals on enzyme activity. Environ. Toxicol. Pharmacol., 32: 69-74.
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16:   Ciftci, M., S. Beydemir and D. Ekinci, 2008. Effects of some drugs on enzyme activity of glucose 6- phosphate dehydrogenase from chicken erythrocytes in vitro. Asian J. Chem., 20: 2189-2196.
17:   Coban, T.A., S. Beydemir, I. Gucin, D. Ekinci, A. Innocenti, D. Vullo and C.T. Supuran, 2009. Sildenafil is a strong activator of mammalian carbonic anhydrase isoforms I-XIV. Bioorg. Med. Chem., 17: 5791-5795.
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18:   Coban, T.A., S. Beydemir, I. Gulcin and D. Ekinci, 2007. Morphine inhibits erythrocyte carbonic anhydrase in vitro and in vivo. Biol. Pharm. Bull., 30: 2257-2261.
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19:   Coban, T.A., S. Beydemir, I. Gulcin and D. Ekinci, 2008. The effect of ethanol on erythrocyte carbonic anhydrase isoenzymes activity: An in vivo and in vitro study. J. Enzyme Inhibit. Med. Chem., 23: 266-270.
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20:   Demirdag, R., E. Yerlikaya, E. Aksakal, O.I. Kufrevioglu and D. Ekinci, 2012. Influence of pesticides on the pH regulatory enzyme, carbonic anhydrase, from European Seabass liver and bovine erythrocytes. Environ. Toxicol. Pharmacol., 34: 218-222.
CrossRef  |  PubMed  |  Direct Link  |  
21:   Demirdag, R., V. Comaklı, M. Senturk, D. Ekinci, O.I. Kufrevioglu and C.T. Supuran, 2012. Purification and characterization of carbonic anhydrase from sheep kidney and influences of sulfonamides on enzyme activity. Bioorg. Med. Chem., 21: 1522-1525.
CrossRef  |  PubMed  |  
22:   Durdagi, S., M. Senturk, D. Ekinci, H.T. Balaydin and S. Goksu et al., 2011. Kinetic and docking studies of phenol-based inhibitors of carbonic anhydrase isoforms I, II, IX and XII evidence a new binding mode within the enzyme active site. Bioorg. Med. Chem., 19: 1381-1389.
CrossRef  |  PubMed  |  Direct Link  |  
23:   Ekinci, D. and M. Senturk, 2011. Assesment of metal inhibition of antioxidant enzyme glutathione reductase from rainbow trout liver. J. Enzyme Inhibit. Med. Chem., 28: 11-15.
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24:   Ekinci, D. and S. Beydemir, 2009. Effect of some analgesics on paraoxonase-1 purified from human serum. J. Enzyme Inhibit. Med. Chem., 24: 1034-1039.
CrossRef  |  PubMed  |  Direct Link  |  
25:   Ekinci, D. and S. Beydemir, 2009. Evaluation of the impacts of antibiotic drugs on PON 1; a major bioscavenger against cardiovascular diseases. Eur. J. Pharmacol., 617: 84-89.
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26:   Ekinci, D. and S. Beydemir, 2010. Purification of PON1 from human serum and assessment of enzyme kinetics against metal toxicity. Biol. Trace. Elem. Res., 135: 112-120.
CrossRef  |  PubMed  |  Direct Link  |  
27:   Ekinci, D. and S. Beydemir, 2010. Risk assessment of pesticides and fungicides for acid-base regulation and salt transport in rainbow trout tissues. Pesticide Biochem. Physiol., 97: 66-70.
CrossRef  |  
28:   Ekinci, D., H. Cavdar, O. Talaz, M. Senturk and C.T. Supuran, 2010. NO-releasing esters show carbonic anhydrase inhibitory action against human isoforms I and II. Bioorg. Med. Chem., 18: 3559-3563.
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29:   Ekinci, D., H. Cavdar, S. Durdagi, O. Talaz, M. Senturk and C.T. Supuran, 2012. Structure-activity relationships for the interaction of 5,10-dihydroindeno[1,2-b]indole derivatives with human and bovine carbonic anhydrase isoforms I, II, III, IV and VI. Eur. J. Med. Chem., 49: 68-73.
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30:   Ekinci, D., L. Karagoz, D. Ekinci, M. Senturk and C.T. Supuran, 2012. Carbonic anhydrase inhibitors: In vitro inhibition of α isoforms (hCA I, hCA II, bCA III, hCA IV) by flavonoids. J. Enzyme Inhib. Med. Chem., 28: 283-288.
CrossRef  |  PubMed  |  
31:   Ekinci, D., M. Al-Rashida, G. Abbas, M. Senturk and C.T. Supuran, 2012. Chromone containing sulfonamides as potent carbonic anhydrase inhibitors. J. Enzyme Inhibit. Med. Chem., 27: 744-747.
CrossRef  |  PubMed  |  Direct Link  |  
32:   Ekinci, D., M. Cankaya, M. Senturk and T.A. Coban, 2012. Susceptibility of cord blood antioxidant enzymes glutathione reductase, glutathione peroxidase and glutathione S-transferase to different antibiotics: In vitro approach. J. Enzyme Inhib. Med.Chem., 28: 824-828.
CrossRef  |  PubMed  |  
33:   Ekinci, D., M. Senturk and O.I. Kufrevioglu, 2011. Salicylic acid derivatives: Synthesis, features and usage as therapeutic tools. Expert Opin. Therapeut. Patents, 21: 1831-1841.
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34:   Ekinci, D., M. Senturk, 2010. Interactions of Fungicides and Pesticides with Specific Enzymes. In: Fungicides, Carisse, O. (Ed.). IN-TECH, Rijeka, Croatia, ISBN: 978-953-307-266-1, pp: 383-404.
35:   Ekinci, D., M. Senturk, S. Beydemir, O.I. Kufrevioglu and C.T. Supuran, 2010. An alternative purification method for human serum paraoxonase 1 and its interactions with sulfonamides. Chem. Biol. Drug Des., 76: 552-558.
CrossRef  |  PubMed  |  Direct Link  |  
36:   Ekinci, D., N.I. Kurbanoglu, E. Salamci, M. Senturk and C.T. Supuran, 2012. Carbonic anhydrase inhibitors: Inhibition of human and bovine isoenzymes by benzenesulphonamides, cyclitols and phenolic compounds. J. Enzyme Inhibit. Med. Chem., 27: 845-848.
CrossRef  |  Direct Link  |  
37:   Ekinci, D., S. Beydemir and O.I. Kufrevioglu, 2007. In vitro inhibitory effects of some heavy metals on human erytrocyte carbonic anhydrases. J. Enzyme Inhibit. Med. Chem., 22: 745-750.
CrossRef  |  PubMed  |  Direct Link  |  
38:   Ekinci, D., S. Beydemir and Z. Alim, 2007. Some drugs inhibit in vitro hydratase and esterase activities of human carbonic anhydrase-I and II. Pharmacol. Rep., 59: 580-587.
PubMed  |  Direct Link  |  
39:   Ekinci, D., S. Beydemir, O.I. Kufrevioglu, M. Ciftci and M. Cankaya et al., 2006. Gene expression analysis of carbonic anhydrase isoenzyme genes in mouse genome by in situ hybridization. FEBS J., 273: 250-251.
40:   Ekinci, D., S.B. Ceyhun, E. Aksakal and O. Erdogan, 2011. IGF and GH mRNA levels are suppressed upon exposure to micromolar concentrations of cobalt and zinc in rainbow trout white muscle. Comp. Biochem. Physiol. C. Toxicol. Pharmacol., 153: 336-341.
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41:   Ekinci, D., S.B. Ceyhun, M. Senturk, D. Erdem, O.I. Kufrevioglu, and C.T. Supuran, 2011. Characterization and anions inhibition studies of an α-carbonic anhydrase from the teleost fish Dicentrarchus labrax. Bioorg. Med. Chem., 19: 744-748.
CrossRef  |  
42:   Erdogan, O., S.B. Ceyhun, D. Ekinci and E. Aksakal, 2011. Impact of deltamethrin exposure on mRNA expression levels of metallothionein A, B and cytochrome P450 1A in rainbow trout muscles. Gene, 484: 13-17.
Direct Link  |  
43:   Gulcin, I., S. Beydemir, T.A. Coban and D. Ekinci, 2008. The Inhibitory effect of dantrolene sodium and propofol on 6-phosphogluconate dehydrogenase from rat erythrocyte. Fresenius Environ. Bull., 17: 1283-1287.
Direct Link  |  
44:   Koz, O., D. Ekinci, M. Senturk, A. Perrone and S. Piacente et al., 2012. Analysis of saponins and phenolic compounds as inhibitors of α-carbonic anhydrase isoenzymes. J. Enzyme Inhib. Med. Chem., 28: 412-417.
CrossRef  |  PubMed  |  
45:   Mercan, L., A. Okumus, M. Senturk and D. Ekinci, 2013. In vitro enzymatic response of Turkish native chicken Gerze to heavy metal exposure. J. Enzyme Inhibit. Med. Chem., 28: 52-57.
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46:   Ozdemir, Z.O., M. Senturk and D. Ekinci, 2013. Inhibition of mammalian carbonic anhydrase isoforms I, II and VI with thiamine and thiamine-like molecules. J. Enzyme Inhibit. Med. Chem., 28: 316-319.
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47:   Senturk, M., D. Ekinci, H.A. Alici and S. Beydemir, 2011. Paraoxonase-1, an organophosphate detoxifier and cardioprotective enzyme, is inhibited by anesthetics: An in vitro and in vivo insight. Biochem. Physiol., 101: 206-211.
CrossRef  |  
48:   Senturk, M., D. Ekinci, S. Goksu and C.T. Supuran, 2012. Effects of dopaminergic compounds on carbonic anhydrase isozymes I, II and VI. J. Enzyme Inhibit. Med. Chem., 27: 365-369.
CrossRef  |  PubMed  |  
49:   Senturk, M., O. Talaz, D. Ekinci, H. Cavdar and O.I. Kufrevioglu, 2009. In vitro inhibition of human erythrocyte glutathione reductase by some new organic nitrates. Bioorganic Med., Chem. Lett., 19: 3661-3663.
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50:   Siktar, E., D. Ekinci, E. Siktar, S. Beydemir, I. Gulcin and M. Gunay, 2011. Protective role of L-carnitine supplementation against exhaustive exercise-induced oxidative stress in rats. Eur. J. Pharmacol., 668: 407-413.
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51:   Talaz, O., H. Cavdar, S. Durdagi, H. Azak and D. Ekinci, 2012. Synthesis of 1,4-bis(indolin-1-ylmethyl) benzene derivatives and their structure-activity relationships for the interaction of human carbonic anhydrase isoforms I and II. Bioorg. Med. Chem., 21: 1477-1482.
CrossRef  |  PubMed  |