Hi, I am Viswas Raja Solomon, My LiveDNA is 91.1264
 
   
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Dr. Viswas Raja Solomon
 
Highest Degree: Ph.D. in Chemistry from Dr. Bhim Rao Ambedkar Open University Agra, India
 
Institute: Nagoya City University, Nagoya, Aichi, Japan
 
Area of Interest: Pharmacology and Toxicology
  •   Pharmaceutical Sciences
  •   Medicinal Chemistry
  •   Analgesic
  •   Anti-Cancer
 
URL: http://livedna.org/91.1264
 
My SELECTED Publications
1:   Alagarsamy, V., B. Narendhar, M.T. Sulthana and V.R. Solomon, 2014. Design and synthesis of 3-(4-chlorophenyl)-2-(2-(4-substituted)-2-oxoethylthio) quinazolin-4 (3H)-one as antihistamine agents. Med. Chem. Res., 23: 4692-4699.
Direct Link  |  
2:   Alagarsamy, V., B.A. Kumar, P. Parthiban, R.V. Sheorey and V.R. Solomon, 2012. Synthesis and antibacterial activity of some novel 1-(4-oxo-3-(3-methoxyphenyl)-3H-quinazolin-2-yl)-4-(substituted) thiosemicarbazides. Anti-infective Agents. 10: 105-110.
Direct Link  |  
3:   Alagarsamy, V., D. Shankar, V.R. Solomon, 2006. Synthesis of some novel 2-Mercapto-3-(substituted amino)-5,6,7,8-tetrahydro-3H-benzo[4,5]thieno[2,3-d]pyrimidin-4-ones as analgesic and Anti-inflammatory agents. ARIKVOC, 16: 149-159.
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4:   Alagarsamy, V., D. Shankar, V.R. Solomon. R.V. Sheorey and P. Parthiban, 2009. Synthesis and pharmacological evaluation of 3-cyclohexyl-2-substituted amino-3H-quinazolin-4-ones as analgesic and anti-inflammatory agent. Acta Pharm., 59: 75-88.
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5:   Alagarsamy, V., H.K. Sharma, P. Parthiban, J.C.H. Singh, S.T. Murugan and V.R. Solomon, 2009. 4-(3-Methoxyphenyl)-1-substituted-4H-[1,2,4]triazolo[4,3-a] quinazolin-5-ones: New class of H1-Antihistaminic agents veerachamy alagarsamy. Pharmazie, 64: 5-9.
CrossRef  |  PubMed  |  
6:   Alagarsamy, V., K. Kavitha, M. Rupeshkumar, V.R. Solomon, D.S. kumar, 2009. Synthesis and pharmacological investigation of novel 4-(3-ethylphenyl)-1-substituted-4H-[1,2,4]triazolo[4,3-a] quinazolin-5-ones as new class of H1-antihistaminic agents. Acta Pharm., 59: 97-106.
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7:   Alagarsamy, V., P. Parthiban, V.R. Solomon, K. Dhanabal, S. Murugesan, G. Saravanan and G.V. Anjana, 2008. Synthesis and pharmacological investigation of novel 4-(4-ethyl phenyl)-1-substituted-4H-[1,2,4]triazolo[4,3-a] quinazolin-5-ones as new class of H1-antihistaminic agents. J. Heterocyclic Chem., 45: 709-715.
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8:   Alagarsamy, V., S. Meena, K.V. Ramaseshu, V.R. Solomon and T.D. Kumar, 2007. 4-Cyclohexyl-1-substituted-4H-[1,2,4]triazolo [4,3-a] quinazolin-5-ones: Novel Class of H1-antihistaminic agents. Chem. Biol. Drug Des., 70: 158-163.
CrossRef  |  PubMed  |  
9:   Alagarsamy, V., S. Meena, K.V. Ramaseshu, V.R. Solomon, T.D. Kumar and K. Thirumurugan, 2007. Synthesis of novel 3-Butyl-2-Substituted Amino-3H-Quinazolin-4-ones as analgesic and Anti-inflammatory agents. Chem. Biol. Drug Des., 70: 254-260.
CrossRef  |  PubMed  |  
10:   Alagarsamy, V., S. Meena, K.V. Ramseshu, V.R. Solomon and K. Thirumurugan, 2008. Synthesis, analgesic, anti-inflammatory and ulcerogenic index activities of novel 2-methylthio-3-substituted-5,6-dimethyl thieno [2,3-d] pyrimidin-4(3H)-ones. Drug Develop. Res., 69: 226-233.
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11:   Alagarsamy, V., S. Meena, K.V. Ramseshu, V.R. Solomon, K. Thirumurugan, K. Dhanabal and M. Murugan, 2006. Synthesis, analgesic, anti-inflammatory, ulcerogenic index and antibacterial activities of novel 2-methylthio-3-substituted-5,6,7,8-tetrahydrobenzo (b) thieno[2,3-d]pyrimidin-4(3H)-ones. Eur. J. Med. Chem., 41: 1293-1300.
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12:   Alagarsamy, V., S. Vijayakumar and V.R. Solomon, 2007. Synthesis of 2-Mercapto-3-substituted-5,6-dimethylthieno[2,3-d] pyrimidin-4(3H)-ones as new analgesic, Anti-inflammatory agents. Biomed. Pharmacotherapy, 61: 285-291.
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13:   Alagarsamy, V., U.S. Pathak, R. Venketeshperumal, S. Meena, K. Thirumurgan, V. Raja Solomon and E. De Clercq, 2003. Anti HIV and antibacterial activites of 2-Subtituted thiadiazolo quinazolines. Indian J. Pharmac. Sci., 65: 293-296.
14:   Alagarsamy, V., U.S. Pathak, R. Venketeshperumal, S. Meena, K. Thirumurgan, V.R. Solomon and E. De Clercq, 2003. Anti HIV and antibacterial activites of 2-substituted thiadiazolo quinazolines. Indian J. Pharm. Sci., 65: 293-296.
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15:   Alagarsamy, V., U.S. Pathak, V.R. Solomon, S. Meena, K.V. Rameshu and R. Rajesh, 2004. Anticancer, antibacterial and antifungal activites of some 2-substituted (1,3,4) thiadiazolo (2,3-b) tetrahydrobenzo (b) thieno (3,2-e) pyrimidines. Indian J. Heterocycl. Chem., 13: 347-350.
Direct Link  |  
16:   Alagarsamy, V., V.R. Solomon and K. Dhanabal, 2007. Synthesis and pharmacological evaluation of some 3-phenyl-2-substituted-3H-quinazolin-4-ones as analgesic, anti-inflammatory agents. Bioorg. Med. Chem., 15: 235-241.
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17:   Alagarsamy, V., V.R. Solomon and M. Murugan, 2007. Synthesis and pharmacological investigation of novel 4-benzyl-1-substituted-4H-[1,2,4]triazolo[4,3-a]quinazolin-5-ones as new class of H1-antihistaminic agents. Bioorg. Med. Chem., 15: 4009-4015.
CrossRef  |  PubMed  |  Direct Link  |  
18:   Alagarsamy, V., V.R. Solomon and S. Murugesan, 2008. Synthesis and pharmacological evaluation of some 3-(2-Methylphenyl)-2-Substituted amino-quinazolin-4(3H)-ones as analgesic and Anti-inflammatory agents. Arzneimittelforschung-Drug Res., 58: 174-181.
PubMed  |  
19:   Alagarsamy, V., V.R. Solomon, G. Deepa, P. Parthiban and G.V. Anjana, 2007. Synthesis and pharmacological investigation of 3-Subsituted-amino-2-methylsulfanyl-5,6,7,8-tetrahydro-3H-benzo[4,5]thieno[2,3-d]pyrimidin-4-ones as analgesic and Anti-Inflammatory agents. Arch. Pharm., 340: 352-358.
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20:   Alagarsamy, V., V.R. Solomon, G.V. Kavitha, V. Paluchamy and M.R. Chandran et al., 2002. Synthesis, analgesic, Anti-inflammatory and antibacterial activities of some novel 2-Phenyl-3-subtituted Quinazolin-4(3H)-ones. Biol. Pharmac. Bull., 25: 1432-1435.
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21:   Alagarsamy, V., V.R. Solomon, M. Murugan, K. Dhanabal, P. Parthiban and G.V. Anjana, 2008. Design and synthesis of 3-(4-Ethylphenyl)-2-substitutedamino-3H-quinazolin-4-ones as novel class of analgesic and Anti-inflammatory agents. J. Enzyme Inhib. Med. Chem., 23: 839-847.
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22:   Alagarsamy, V., V.R. Solomon, P. Parthiban, R. Rajeshwari and G.V. Anjana, 2010. Synthesis and analgesic, Anti-inflammatory activities of 3-(3-Methoxyphenyl)-2-Substituted amino-quinazolin-4(3H)-ones. Med. Chem. Res., (In Press) 10.1007/s00044-010-9417-z.
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23:   Alagarsamy, V., V.R. Solomon, P. Parthiban, R. Rajeshwari and G.V. Anjana, 2011. Synthesis and Analgesic, Anti-inflammatory Activities of 3-(3-Methoxyphenyl)-2-Substituted amino-quinazolin-4(3H)-ones. Med. Chem. Res., 20: 946-954.
CrossRef  |  
24:   Alagarsamy, V., V.R. Solomon, R. Meena and K.V. Ramseshu, 2005. Synthesis, analgesic, Anti-inflammatory and antibacterial activities of some novel 2-Butyl-3-subtituted Quinazolin-4(3H)-ones. Biol. Pharmac. Bull., 28: 1091-1094.
CrossRef  |  PubMed  |  
25:   Alagarsamy, V., V.R. Solomon, R. Meena, K.V. Ramaseshu, K. Thirumurugan and S. Murugesan, 2007. Design and synthesis of 2-Methylthio-3-substituted-5,6-dimethylthieno [2,3-d] pyrimidin-4(3H)-ones as analgesic Anti-Inflammatory and antibacterial agents. Med. Chem., 3: 67-73.
CrossRef  |  PubMed  |  
26:   Alagarsamy, V., V.R. Solomon, R. Sankaranarayanan, P. Periyasamy, R. Deepa and T.D. Anandkumar, 2008. Synthesis of 3-(2-pyridyl)-2-Substituted-quinazolin-4(3H)-ones as new analgesic and Anti-inflammatory agents. Biomed. Pharmacother, 62: 454-461.
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27:   Alagarsamy, V., V.R. Solomon, R.V. Sheorey. R. Jayakumar, 2009. Synthesis of 3-(3-Ethylphenyl)-2-substituted amino-3H-quinazolin-4-ones as novel class of Analgesic and Anti-inflammatory agents. Chem. Biol. Drug Des., 73: 471-479.
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28:   Desphande, S., Solomon, V.R., S.B. Katti and Y.S. Prabhakar, 2009. Topological descriptors in modelling antimalarial activity: N1-(7-chloro-4-quinolyl)-1,4-bis(3-aminopropyl)piperazine as prototype. J. Enzyme Inhib. Med. Chem., 24: 94-104.
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29:   Gokulan, P.D., B. Jayakar and V. Alagarsamy and V.R. Solomon, 2012. Synthesis and pharmacological investigation of 5-substituted-3-methylsulfanyl-1H-pyrazole-4-carboxylic acid ethyl esters as new analgesic and anti-inflammatory agents. Arzneim.Forsch. .
PubMed  |  
30:   Hu, C., V.R. Solomon, G. Ulibarri and H. Lee, 2008. The efficacy and selectivity of tumor cell killing by Akt inhibitors are substantially increased by chloroquine. Bioorg. Med. Chem., 16: 7888-7893.
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31:   Hu, C., V.R. Solomon, P. Cano and H. Lee, 2010. A 4-aminoquinoline derivative that markedly sensitizes tumor cell killing by Akt inhibitors with a minimum cytotoxicity to non-cancer cells. Eur. J. Med. Chem., 45: 705-709.
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32:   Kadri, D., A.K. Crater, H. Lee, V.R. Solomon and S. Ananvoranich, 2014. The potential of quinoline derivatives for the treatment of Toxoplasma gondii infection. Exp. Parasitol., 145: 135-144.
PubMed  |  
33:   Patel, K., C. Karthikeyan, N.S.H.N. Moorthy, G.S. Deora, V.R. Solomon, H. Lee and P. Trivedi, 2012. Design, synthesis and biological evaluation of some novel 3-cinnamoyl-4-hydroxy-2H-chromen-2-ones as antimalarial agents. Med. Chem. Res., 21: 1780-1784.
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34:   Patel, K., C. Karthikeyan, V.R. Solomon, N.S.H.N. Moorthy and H. Lee et al., 2011. Synthesis of some coumarinyl chalcones and their antiproliferative activity against breast cancer cell lines. Lett. Drug Des. Discov., 8: 308-311.
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35:   Prabakar, Y.S., V.R. Solomon, R.K. Rawal, M.K.Gupta and S.B. Katti, 2004. CP-MLR/PLS directed structure activtity molecular modeling of the HIV-1 RT inhibitory activity of 2,3-Diaryl-1,3-thiazolidin-4-ones. QSAR Comb. Sci., 23: 234-244.
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36:   Prabhakar, Y.S., R.K. Rawal, M.K. Gupta, V.R. Solomon and S.B. Katti, 2005. Topological descriptors in modeling the HIV-RT inhibitory activityof 2-aryl-3-pyridyl-thiazolidin-4-one. Combinatorial Chem. High-Throughput Screening, 8: 431-437.
PubMed  |  
37:   Rawal, R.K., V.R. Solomon, Y.S. Prabhakar, S.B. Katti and E. De Clercq, 2005. Synthesis and QSAR studies on thiazolidinones as HIV-RT inhibitors. Combinatorial Chem. High-throughput Screening, 8: 439-443.
PubMed  |  
38:   Senthilraja, M., V. Alagarsamy and V.R. Solomon, 2012. 2,3-disubtituted thiazolidin-4-ones: Novel class of anticonvulsant agents. Lett. Drug Des. Discov., 9: 731-735.
39:   Solomon, V.R. and H. Lee, 2009. Chloroquine and its analogs: A new promise of an old drug for effective and safe cancer therapies. Eur. J. Pharm., 625: 220-223.
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40:   Solomon, V.R. and H. Lee, 2011. Quinoline is a privileged scaffold for cancer drug discovery. Curr. Med. Chem., 18: 1488-1508.
41:   Solomon, V.R. and H. Lee, 2012. Anti-breast cancer activity of heteroaryl chalcone derivatives. Biomed. Pharmacother., 66: 213-220.
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42:   Solomon, V.R. and S.C. Chaturvedi, 2003. Analysis of a series of new pyrazolidine-3,5-diones as selective AT1 angiotensin Ii receptor antagonists. Indian Pharm., 15: 53-58.
43:   Solomon, V.R., C. Hu adn H. Lee, 2010. Design and synthesis of CQ analogs for their anti-breast cancer property. Eur. J. Med. Chem., 45: 3916-3923.
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44:   Solomon, V.R., C. Hu and H. Lee, 2009. Hybrid pharmacophore design and synthesis of isatin-benzothiazole analogs for their anti-breast cancer activity. Bioorg. Med. Chem., 17: 7585-7592.
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45:   Solomon, V.R., C. Hu and H. Lee, 2010. Design and synthesis of anti-breast cancer agents from 4-piperazinylquinoline: A hybrid pharmacophore approach. Bioorganic Med. Chem., 18: 1563-1572.
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46:   Solomon, V.R., C. Hu and H. Lee, 2010. Design and synthesis of chloroquine analogs for their anti-breast cancer property. Eur. J. Med. Chem., 45: 3916-3923.
PubMed  |  
47:   Solomon, V.R., R.K. Sharma and S.C. Chaturvedi, 2002. Angiotensin antagonist: As antihypertensive agents. Indian Pharm., 1: 6-8.
48:   Solomon, V.R., S.K. Puri, K. Srivastava and S.B. Katti, 2005. Design and synthesis of new antimalarial agents from 4-aminoquinoline. Bioorg. Med. Chem., 13: 2157-2165.
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49:   Solomon, V.R., W. Haq, K. Srivastava, S.K. Puri and S.B. Katti, 2012. Design and synthesis of 3-[(7-chloro-1-oxidoquinolin-4-ylamino)alkyl]-1,3-thiazolidin-4-ones as antimalarial agents. J. Enzyme Inhib. Med. Chem. .
PubMed  |  
50:   Solomon, V.R., W. Haq, K. Srivastava, S.K. Puri, S.B. Katti, 2012. Design, Synthesis of 4-aminoquinoline derived thiazolidines and their antimalarial activity and heme polymerization inhibition studies. J. Enzyme Inhib. Med. Chem. 10.3109/14756366.2012.666537.
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51:   Solomon, V.R., W. Haq, M. Smilkstein, K. Srivastava, S. Rajakumar, S.K. Puri and S.B. Katti, 2008. Synthesis and antimalarial activity of novel side chain modified antimalarial agents from 4-aminoquinoline. Med. Chem., 4: 446-451.
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52:   Solomon, V.R., W. Haq, M. Smilkstein, K. Srivastava, S.K. Puri and S.B. Katti, 2010. 4-Aminoquinoline derived antimalarials: Synthesis and heme polymerization inhibition studies. Eur. J. Med. Chem., 45: 4990-4996.
PubMed  |  
53:   Solomon, V.R., W. Haq, S.K. Puri, K. Srivastava and S.B. Katti, 2006. Design, synthesis and antimalarial activity of a new class of iron chelators. Med. Chem., 2: 1-6.
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54:   Solomon, V.R., W. Haq, S.K. Puri, K. Srivastava and S.B. Katti, 2007. Synthesis and antimalarial activity of side chain modified 4-aminoquinoline derivatives. J. Med. Chem., 50: 394-398.
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55:   Solomon, V.R., and S.C. Chaturvedi, 2004. QSAR Studies of diphenylpropionic acids based selective AT1 angiotensin II receptor antagonist as antihypertensive agents. Indian J. Heterocycl. Chem., 13: 373-396.
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56:   Zhang, H., V.R. Solomon, C. Hu, G. Ulibarri and H. Lee, 2008. Synthesis and in vitro cytotoxicity evaluation of 4-aminoquinoline derivatives. Biomed. Pharmacotherapy, 62: 65-69.
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