Dr. Viswas Raja Solomon

Dr. Viswas Raja Solomon

Research Scientist
University of Sydney, Australia


Highest Degree
Ph.D. in Chemistry from Dr. Bhim Rao Ambedkar Open University Agra, India

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Biography

Dr. Raja Solomon Viswas was born in Aruppukottai, India. He received his bachelors degree in Pharmacy in 1999 from the S. B. College of Pharmacy, the Tamilnadu Dr. M. G. R. Medical University, Chennai, India and Masters degree in Pharmacy with specialization of Medicinal & Pharmaceutical Chemistry (2002) from the S. G. S. Institute of Technology, the Rajiv Gandhi Technical University, Bhopal, India. He completed his Ph.D. in 2007 in the field of Medicinal Chemistry at the CSIR-Central Drug Research Institute (CDRI), Lucknow, India then moved to Advanced Medical Research Institute of Canada as an Ontario Government of Ministry of Research innovation postdoctoral fellow (2007-2010) in the research group of Prof. Hoyun Lee. He then worked as a JSPS postdoctoral fellow (2010-2013) in the Organic and Medicinal Chemistry Laboratory of Nagoya City University, Japan with Prof. Naoki Miyata. He is presently working as a Research fellow at the Faculty of Pharmacy at the University of Sydney, Australia. His research interests include development of new agents for the treatment of neurological disorders, design, synthesis, and biological evaluation of hybrid molecules for Cancer Drug Discovery, and development of new synthetic methodologies for application in organic synthesis. His expertise is recognized by 4 international editorial appointments and reviewer for 20 international journals. He published (56) articles in journals, (3) review articles, (2) book chapter, and (15) conference proceeding as author/co-author. Dr. Raja Solomon Viswas received number of awards includeing Foreign Researcher, Postdoctoral Fellowship, Senior Research Fellowship, Junior Research Fellowship award. He is also supervising number of PhD and MSc students.

Area of Interest:

Pharmacology and Toxicology
100%
Pharmaceutical Sciences
62%
Medicinal Chemistry
90%
Analgesic
75%
Cancer Pharmacology
55%

Selected Publications

  1. Kadri, D., A.K. Crater, H. Lee, V.R. Solomon and S. Ananvoranich, 2014. The potential of quinoline derivatives for the treatment of Toxoplasma gondii infection. Exp. Parasitol., 145: 135-144.
    PubMed  |  

  2. Alagarsamy, V., B. Narendhar, M.T. Sulthana and V.R. Solomon, 2014. Design and synthesis of 3-(4-chlorophenyl)-2-(2-(4-substituted)-2-oxoethylthio) quinazolin-4 (3H)-one as antihistamine agents. Med. Chem. Res., 23: 4692-4699.
    Direct Link  |  

  3. Solomon, V.R., W. Haq, K. Srivastava, S.K. Puri, S.B. Katti, 2012. Design, Synthesis of 4-aminoquinoline derived thiazolidines and their antimalarial activity and heme polymerization inhibition studies. J. Enzyme Inhib. Med. Chem. 10.3109/14756366.2012.666537.
    CrossRef  |  PubMed  |  

  4. Solomon, V.R., W. Haq, K. Srivastava, S.K. Puri and S.B. Katti, 2012. Design and synthesis of 3-[(7-chloro-1-oxidoquinolin-4-ylamino)alkyl]-1,3-thiazolidin-4-ones as antimalarial agents. J. Enzyme Inhib. Med. Chem. .
    PubMed  |  

  5. Solomon, V.R. and H. Lee, 2012. Anti-breast cancer activity of heteroaryl chalcone derivatives. Biomed. Pharmacother., 66: 213-220.
    CrossRef  |  

  6. Senthilraja, M., V. Alagarsamy and V.R. Solomon, 2012. 2,3-disubtituted thiazolidin-4-ones: Novel class of anticonvulsant agents. Lett. Drug Des. Discov., 9: 731-735.

  7. Patel, K., C. Karthikeyan, N.S.H.N. Moorthy, G.S. Deora, V.R. Solomon, H. Lee and P. Trivedi, 2012. Design, synthesis and biological evaluation of some novel 3-cinnamoyl-4-hydroxy-2H-chromen-2-ones as antimalarial agents. Med. Chem. Res., 21: 1780-1784.
    CrossRef  |  

  8. Gokulan, P.D., B. Jayakar and V. Alagarsamy and V.R. Solomon, 2012. Synthesis and pharmacological investigation of 5-substituted-3-methylsulfanyl-1H-pyrazole-4-carboxylic acid ethyl esters as new analgesic and anti-inflammatory agents. Arzneim.Forsch. .
    PubMed  |  

  9. Alagarsamy, V., B.A. Kumar, P. Parthiban, R.V. Sheorey and V.R. Solomon, 2012. Synthesis and antibacterial activity of some novel 1-(4-oxo-3-(3-methoxyphenyl)-3H-quinazolin-2-yl)-4-(substituted) thiosemicarbazides. Anti-infective Agents. 10: 105-110.
    Direct Link  |  

  10. Solomon, V.R. and H. Lee, 2011. Quinoline is a privileged scaffold for cancer drug discovery. Curr. Med. Chem., 18: 1488-1508.

  11. Patel, K., C. Karthikeyan, V.R. Solomon, N.S.H.N. Moorthy and H. Lee et al., 2011. Synthesis of some coumarinyl chalcones and their antiproliferative activity against breast cancer cell lines. Lett. Drug Des. Discov., 8: 308-311.
    Direct Link  |  

  12. Alagarsamy, V., V.R. Solomon, P. Parthiban, R. Rajeshwari and G.V. Anjana, 2011. Synthesis and Analgesic, Anti-inflammatory Activities of 3-(3-Methoxyphenyl)-2-Substituted amino-quinazolin-4(3H)-ones. Med. Chem. Res., 20: 946-954.
    CrossRef  |  

  13. Solomon, V.R., W. Haq, M. Smilkstein, K. Srivastava, S.K. Puri and S.B. Katti, 2010. 4-Aminoquinoline derived antimalarials: Synthesis and heme polymerization inhibition studies. Eur. J. Med. Chem., 45: 4990-4996.
    PubMed  |  

  14. Solomon, V.R., C. Hu and H. Lee, 2010. Design and synthesis of chloroquine analogs for their anti-breast cancer property. Eur. J. Med. Chem., 45: 3916-3923.
    PubMed  |  

  15. Solomon, V.R., C. Hu and H. Lee, 2010. Design and synthesis of anti-breast cancer agents from 4-piperazinylquinoline: A hybrid pharmacophore approach. Bioorganic Med. Chem., 18: 1563-1572.
    CrossRef  |  

  16. Solomon, V.R., C. Hu adn H. Lee, 2010. Design and synthesis of CQ analogs for their anti-breast cancer property. Eur. J. Med. Chem., 45: 3916-3923.
    CrossRef  |  

  17. Hu, C., V.R. Solomon, P. Cano and H. Lee, 2010. A 4-aminoquinoline derivative that markedly sensitizes tumor cell killing by Akt inhibitors with a minimum cytotoxicity to non-cancer cells. Eur. J. Med. Chem., 45: 705-709.
    CrossRef  |  PubMed  |  

  18. Alagarsamy, V., V.R. Solomon, P. Parthiban, R. Rajeshwari and G.V. Anjana, 2010. Synthesis and analgesic, Anti-inflammatory activities of 3-(3-Methoxyphenyl)-2-Substituted amino-quinazolin-4(3H)-ones. Med. Chem. Res., (In Press) 10.1007/s00044-010-9417-z.
    CrossRef  |  

  19. Solomon, V.R., C. Hu and H. Lee, 2009. Hybrid pharmacophore design and synthesis of isatin-benzothiazole analogs for their anti-breast cancer activity. Bioorg. Med. Chem., 17: 7585-7592.
    CrossRef  |  

  20. Solomon, V.R. and H. Lee, 2009. Chloroquine and its analogs: A new promise of an old drug for effective and safe cancer therapies. Eur. J. Pharm., 625: 220-223.
    CrossRef  |  Direct Link  |  

  21. Desphande, S., Solomon, V.R., S.B. Katti and Y.S. Prabhakar, 2009. Topological descriptors in modelling antimalarial activity: N1-(7-chloro-4-quinolyl)-1,4-bis(3-aminopropyl)piperazine as prototype. J. Enzyme Inhib. Med. Chem., 24: 94-104.
    CrossRef  |  PubMed  |  

  22. Alagarsamy, V., V.R. Solomon, R.V. Sheorey. R. Jayakumar, 2009. Synthesis of 3-(3-Ethylphenyl)-2-substituted amino-3H-quinazolin-4-ones as novel class of Analgesic and Anti-inflammatory agents. Chem. Biol. Drug Des., 73: 471-479.
    CrossRef  |  

  23. Alagarsamy, V., K. Kavitha, M. Rupeshkumar, V.R. Solomon, D.S. kumar, 2009. Synthesis and pharmacological investigation of novel 4-(3-ethylphenyl)-1-substituted-4H-[1,2,4]triazolo[4,3-a] quinazolin-5-ones as new class of H1-antihistaminic agents. Acta Pharm., 59: 97-106.
    CrossRef  |  

  24. Alagarsamy, V., H.K. Sharma, P. Parthiban, J.C.H. Singh, S.T. Murugan and V.R. Solomon, 2009. 4-(3-Methoxyphenyl)-1-substituted-4H-[1,2,4]triazolo[4,3-a] quinazolin-5-ones: New class of H1-Antihistaminic agents veerachamy alagarsamy. Pharmazie, 64: 5-9.
    CrossRef  |  PubMed  |  

  25. Alagarsamy, V., D. Shankar, V.R. Solomon. R.V. Sheorey and P. Parthiban, 2009. Synthesis and pharmacological evaluation of 3-cyclohexyl-2-substituted amino-3H-quinazolin-4-ones as analgesic and anti-inflammatory agent. Acta Pharm., 59: 75-88.
    CrossRef  |  

  26. Zhang, H., V.R. Solomon, C. Hu, G. Ulibarri and H. Lee, 2008. Synthesis and in vitro cytotoxicity evaluation of 4-aminoquinoline derivatives. Biomed. Pharmacotherapy, 62: 65-69.
    CrossRef  |  PubMed  |  

  27. Solomon, V.R., W. Haq, M. Smilkstein, K. Srivastava, S. Rajakumar, S.K. Puri and S.B. Katti, 2008. Synthesis and antimalarial activity of novel side chain modified antimalarial agents from 4-aminoquinoline. Med. Chem., 4: 446-451.
    CrossRef  |  PubMed  |  

  28. Hu, C., V.R. Solomon, G. Ulibarri and H. Lee, 2008. The efficacy and selectivity of tumor cell killing by Akt inhibitors are substantially increased by chloroquine. Bioorg. Med. Chem., 16: 7888-7893.
    CrossRef  |  PubMed  |  

  29. Alagarsamy, V., V.R. Solomon, R. Sankaranarayanan, P. Periyasamy, R. Deepa and T.D. Anandkumar, 2008. Synthesis of 3-(2-pyridyl)-2-Substituted-quinazolin-4(3H)-ones as new analgesic and Anti-inflammatory agents. Biomed. Pharmacother, 62: 454-461.
    CrossRef  |  PubMed  |  

  30. Alagarsamy, V., V.R. Solomon, M. Murugan, K. Dhanabal, P. Parthiban and G.V. Anjana, 2008. Design and synthesis of 3-(4-Ethylphenyl)-2-substitutedamino-3H-quinazolin-4-ones as novel class of analgesic and Anti-inflammatory agents. J. Enzyme Inhib. Med. Chem., 23: 839-847.
    CrossRef  |  PubMed  |  

  31. Alagarsamy, V., V.R. Solomon and S. Murugesan, 2008. Synthesis and pharmacological evaluation of some 3-(2-Methylphenyl)-2-Substituted amino-quinazolin-4(3H)-ones as analgesic and Anti-inflammatory agents. Arzneimittelforschung-Drug Res., 58: 174-181.
    PubMed  |  

  32. Alagarsamy, V., S. Meena, K.V. Ramseshu, V.R. Solomon and K. Thirumurugan, 2008. Synthesis, analgesic, anti-inflammatory and ulcerogenic index activities of novel 2-methylthio-3-substituted-5,6-dimethyl thieno [2,3-d] pyrimidin-4(3H)-ones. Drug Develop. Res., 69: 226-233.
    CrossRef  |  

  33. Alagarsamy, V., P. Parthiban, V.R. Solomon, K. Dhanabal, S. Murugesan, G. Saravanan and G.V. Anjana, 2008. Synthesis and pharmacological investigation of novel 4-(4-ethyl phenyl)-1-substituted-4H-[1,2,4]triazolo[4,3-a] quinazolin-5-ones as new class of H1-antihistaminic agents. J. Heterocyclic Chem., 45: 709-715.
    CrossRef  |  

  34. Solomon, V.R., W. Haq, S.K. Puri, K. Srivastava and S.B. Katti, 2007. Synthesis and antimalarial activity of side chain modified 4-aminoquinoline derivatives. J. Med. Chem., 50: 394-398.
    CrossRef  |  PubMed  |  

  35. Alagarsamy, V., V.R. Solomon, R. Meena, K.V. Ramaseshu, K. Thirumurugan and S. Murugesan, 2007. Design and synthesis of 2-Methylthio-3-substituted-5,6-dimethylthieno [2,3-d] pyrimidin-4(3H)-ones as analgesic Anti-Inflammatory and antibacterial agents. Med. Chem., 3: 67-73.
    CrossRef  |  PubMed  |  

  36. Alagarsamy, V., V.R. Solomon, G. Deepa, P. Parthiban and G.V. Anjana, 2007. Synthesis and pharmacological investigation of 3-Subsituted-amino-2-methylsulfanyl-5,6,7,8-tetrahydro-3H-benzo[4,5]thieno[2,3-d]pyrimidin-4-ones as analgesic and Anti-Inflammatory agents. Arch. Pharm., 340: 352-358.
    CrossRef  |  PubMed  |  

  37. Alagarsamy, V., V.R. Solomon and M. Murugan, 2007. Synthesis and pharmacological investigation of novel 4-benzyl-1-substituted-4H-[1,2,4]triazolo[4,3-a]quinazolin-5-ones as new class of H1-antihistaminic agents. Bioorg. Med. Chem., 15: 4009-4015.
    CrossRef  |  PubMed  |  Direct Link  |  

  38. Alagarsamy, V., V.R. Solomon and K. Dhanabal, 2007. Synthesis and pharmacological evaluation of some 3-phenyl-2-substituted-3H-quinazolin-4-ones as analgesic, anti-inflammatory agents. Bioorg. Med. Chem., 15: 235-241.
    CrossRef  |  

  39. Alagarsamy, V., S. Vijayakumar and V.R. Solomon, 2007. Synthesis of 2-Mercapto-3-substituted-5,6-dimethylthieno[2,3-d] pyrimidin-4(3H)-ones as new analgesic, Anti-inflammatory agents. Biomed. Pharmacotherapy, 61: 285-291.
    CrossRef  |  

  40. Alagarsamy, V., S. Meena, K.V. Ramaseshu, V.R. Solomon, T.D. Kumar and K. Thirumurugan, 2007. Synthesis of novel 3-Butyl-2-Substituted Amino-3H-Quinazolin-4-ones as analgesic and Anti-inflammatory agents. Chem. Biol. Drug Des., 70: 254-260.
    CrossRef  |  PubMed  |  

  41. Alagarsamy, V., S. Meena, K.V. Ramaseshu, V.R. Solomon and T.D. Kumar, 2007. 4-Cyclohexyl-1-substituted-4H-[1,2,4]triazolo [4,3-a] quinazolin-5-ones: Novel Class of H1-antihistaminic agents. Chem. Biol. Drug Des., 70: 158-163.
    CrossRef  |  PubMed  |  

  42. Solomon, V.R., W. Haq, S.K. Puri, K. Srivastava and S.B. Katti, 2006. Design, synthesis and antimalarial activity of a new class of iron chelators. Med. Chem., 2: 1-6.
    CrossRef  |  PubMed  |  

  43. Alagarsamy, V., S. Meena, K.V. Ramseshu, V.R. Solomon, K. Thirumurugan, K. Dhanabal and M. Murugan, 2006. Synthesis, analgesic, anti-inflammatory, ulcerogenic index and antibacterial activities of novel 2-methylthio-3-substituted-5,6,7,8-tetrahydrobenzo (b) thieno[2,3-d]pyrimidin-4(3H)-ones. Eur. J. Med. Chem., 41: 1293-1300.
    CrossRef  |  PubMed  |  

  44. Alagarsamy, V., D. Shankar, V.R. Solomon, 2006. Synthesis of some novel 2-Mercapto-3-(substituted amino)-5,6,7,8-tetrahydro-3H-benzo[4,5]thieno[2,3-d]pyrimidin-4-ones as analgesic and Anti-inflammatory agents. ARIKVOC, 16: 149-159.
    Direct Link  |  

  45. Solomon, V.R., S.K. Puri, K. Srivastava and S.B. Katti, 2005. Design and synthesis of new antimalarial agents from 4-aminoquinoline. Bioorg. Med. Chem., 13: 2157-2165.
    CrossRef  |  PubMed  |  

  46. Rawal, R.K., V.R. Solomon, Y.S. Prabhakar, S.B. Katti and E. De Clercq, 2005. Synthesis and QSAR studies on thiazolidinones as HIV-RT inhibitors. Combinatorial Chem. High-throughput Screening, 8: 439-443.
    PubMed  |  

  47. Prabhakar, Y.S., R.K. Rawal, M.K. Gupta, V.R. Solomon and S.B. Katti, 2005. Topological descriptors in modeling the HIV-RT inhibitory activityof 2-aryl-3-pyridyl-thiazolidin-4-one. Combinatorial Chem. High-Throughput Screening, 8: 431-437.
    PubMed  |  

  48. Alagarsamy, V., V.R. Solomon, R. Meena and K.V. Ramseshu, 2005. Synthesis, analgesic, Anti-inflammatory and antibacterial activities of some novel 2-Butyl-3-subtituted Quinazolin-4(3H)-ones. Biol. Pharmac. Bull., 28: 1091-1094.
    CrossRef  |  PubMed  |  

  49. Solomon, V.R., and S.C. Chaturvedi, 2004. QSAR Studies of diphenylpropionic acids based selective AT1 angiotensin II receptor antagonist as antihypertensive agents. Indian J. Heterocycl. Chem., 13: 373-396.
    Direct Link  |  

  50. Prabakar, Y.S., V.R. Solomon, R.K. Rawal, M.K.Gupta and S.B. Katti, 2004. CP-MLR/PLS directed structure activtity molecular modeling of the HIV-1 RT inhibitory activity of 2,3-Diaryl-1,3-thiazolidin-4-ones. QSAR Comb. Sci., 23: 234-244.
    CrossRef  |  

  51. Alagarsamy, V., U.S. Pathak, V.R. Solomon, S. Meena, K.V. Rameshu and R. Rajesh, 2004. Anticancer, antibacterial and antifungal activites of some 2-substituted (1,3,4) thiadiazolo (2,3-b) tetrahydrobenzo (b) thieno (3,2-e) pyrimidines. Indian J. Heterocycl. Chem., 13: 347-350.
    Direct Link  |  

  52. Solomon, V.R. and S.C. Chaturvedi, 2003. Analysis of a series of new pyrazolidine-3,5-diones as selective AT1 angiotensin Ii receptor antagonists. Indian Pharm., 15: 53-58.

  53. Alagarsamy, V., U.S. Pathak, R. Venketeshperumal, S. Meena, K. Thirumurgan, V.R. Solomon and E. De Clercq, 2003. Anti HIV and antibacterial activites of 2-substituted thiadiazolo quinazolines. Indian J. Pharm. Sci., 65: 293-296.
    Direct Link  |  

  54. Alagarsamy, V., U.S. Pathak, R. Venketeshperumal, S. Meena, K. Thirumurgan, V. Raja Solomon and E. De Clercq, 2003. Anti HIV and antibacterial activites of 2-Subtituted thiadiazolo quinazolines. Indian J. Pharmac. Sci., 65: 293-296.

  55. Solomon, V.R., R.K. Sharma and S.C. Chaturvedi, 2002. Angiotensin antagonist: As antihypertensive agents. Indian Pharm., 1: 6-8.

  56. Alagarsamy, V., V.R. Solomon, G.V. Kavitha, V. Paluchamy and M.R. Chandran et al., 2002. Synthesis, analgesic, Anti-inflammatory and antibacterial activities of some novel 2-Phenyl-3-subtituted Quinazolin-4(3H)-ones. Biol. Pharmac. Bull., 25: 1432-1435.
    CrossRef  |  PubMed  |