Prof. Dr. Anna Pratima Ganpatrao Nikalje
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Prof. Dr. Anna Pratima Ganpatrao Nikalje

Professor
Y. B. Chavan College Of Pharmacy, India


Highest Degree
Ph.D. in Chemistry from Dr. Babasaheb Ambedkar Marathwada University, India

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Area of Interest:

Chemistry
100%
Pharmaceutical Chemistry
62%
Drug Delivery Systems
90%
Organic Chemistry
75%
Chromatography
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
0
Abstracts
0

Selected Publications

  1. Tiwari, S.V., S. Siddiqui, J.A. Seijas, M.P. Vazquez-Tato, A.P. Sarkate, D.K. Lokwani and A.P.G. Nikalje, 2017. Assisted facile synthesis, anticancer evaluation and docking study of n-((5- (substituted methylene amino)-1,3,4-thiadiazol-2-yl)methyl) benzamide derivatives. Molecules, 22: 995-995.
  2. Tiwari, S.V., J.A. Seijas, M.P. Vazquez-Tato, A.P. Sarkate, K.S. Karnik and A.P.G. Nikalje, 2017. Facile synthesis of novel coumarin derivatives, antimicrobial analysis, enzyme assay, docking study, admet prediction and toxicity study. Molecules, 10.3390/molecules22071172.
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  3. Tiwari, S.V., A.P.G. Nikalje, D.K. Lokwani, A.P. Sarkate and J.Kizukala, 2017. Synthesis, biological evaluation, molecular docking study and acute oral toxicity study of coupled imidazole-pyrimidine derivatives. Lett. Drug Des. Discovery, 10.2174/1570180814666170704101817 .
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  4. Shahana, S. and A.P.G. Nikalje, 2017. A brief review on Bauhinia variegata: Phytochemistry, antidiabetic and antioxidant potential. Am. J. Pharm. Tech. Res., 7: 186-197.
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  5. Nimbalkar, U.D., J.A. Seijas, M.P. Vazquez-Tato , M.G. Damale, J.N. Sangshetti, and A.P.G. Nikalje, 2017. Ionic liquid-catalyzed green protocol for multi-component synthesis of dihydropyrano[2,3-c]pyrazoles as potential anticancer scaffolds. Molecules, 22: 1-17.
  6. Nikaljea, A.P. and K. Baheti, 2017. Computer based drug design of various heterocyclic compounds having anticancer activity: A brief review. J. Bioinf. Genomics Proteomics, 2: 1-13.
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  7. Nikalje,A.P. and S. Tiwari, 2017. Epilepsy: Novel Gaba Modulating Agents and Gabaergic Imbalance In Cns. Scholars' Press, Germany, ISBN: 9783659845154 Pages: 192.
  8. Nikalje, A.P.G., S.V. Tiwari, J.G. Tupe, V.K. Vyas and G. Qureshi, 2017. Ultrasound assisted-synthesis and biological evaluation of piperazinylprop- 1-en-2-yloxy-2h-chromen-2-ones as cytotoxic agents. Lett. Drug Des. Discovery, 14: 1195-1205.
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  9. Nikalje, A.P.G., S. Baheti, S. Kamble, S. Khan and J.N. Sangshetti, 2017. Isolation of phyto constituents from the roots of coleus forskohlii by column and flash chromatographic method. Am. J. Pharm. Sci., 4: 74-84.
  10. Nikalje, A.P., 2017. Nanotechnology and Its Applications in Medicine. Scholar's Press, Germany, ISBN: 9783330653467 Pages: 68.
  11. Nikalje, A.P. and M. Ghodke, 2017. Design,Synthesis& Pharmacological Screening of Some Novel Heterocycles. Verlag, Scholars’s Press, Germany, ISBN: 9783330651272 Pages: 408.
  12. Nikalje, A.P. and D. Bhosale, 2017. Analytical Method Development of New Drugs from Bulk and Formulations. Verlag, Scholars’ Press, Germany, ISBN 9783330652118 Pages: 268.
  13. Nikalje, A.P. and D. Bhosale, 2017. A Hand Book of Chromatography. Verlag Publishers: Scholars’ Press, Germany, ISBN: 9783330650329.
  14. Doherty,W., N. Adler, A. Knox, D. Nolan, J. McGouran, A. P. Nikalje, D. Lokwani, A. Sarkate and P. Evans, 2017. Synthesis and evaluation of 1,2,3-triazole-containing vinyl and allyl sulfones as anti-trypanosomal agents. Eur. J. Organic Chem., 2017: 175-185.
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  15. Chivte, V.K., S.V. Tiwari and A.P.G. Nikalje, 2017. Bioenhancers: A brief review. Adv. J. Pharm. Life Sc.i Res., 5: 2-18.
  16. Tiwari, S.V., J.A. Seijas, M.P.Vazquez-Tato, A.P. Sarkate, D.K. Lokwani and A.P. Nikalje, 2016. Ultrasound mediated one-pot, three component synthesis, docking and adme prediction of novel 5-amino-2-(4-chlorophenyl)-7-substituted phenyl-8,8a-dihydro-7h-(1,3,4)thiadiazolo(3,2-α)pyrimidine-6-carbonitrile derivatives as anticancer agents. Molecules, 10.3390/molecules21080894.
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  17. Nimbalkar, U.D., S.G. Tupe, J.A.S. Vazquez, F.A. Khan, J.N. Sangshetti and A.P. Nikalje, 2016. Ultrasound- and molecular sieves-assisted synthesis, molecular docking and antifungal evaluation of 5-(4-(benzyloxy)-substituted phenyl)-3-((phenylamino)methyl)-1,3,4-oxadiazole-2(3H)-thiones. Molecules, 10.3390/molecules21050484.
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  18. Nikalje, A.P.G., M.S. Ghodke, F.A.K. Khan and J.N. Sangshetti, 2016. Microwave assisted facile synthesis and biological evaluation of novel 2-indolyl -1, 5- benzothiazepines. Bentham Open Open Pharm. Sci. J., 3: 79-92.
  19. Bhosale, D.M. and A.P.G. Nikalje, 2016. UPLC method for determination of eight flupirtine impurities in bulk substance and their characterization by 1h nmr and esi–ms. Chromatographia, 79: 833-839.
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  20. Bhosale, D.M. and A.P.G. Nikalje, 2016. Development of lc-ms method for characterization of drotaverine hydrochloride impurities. Am. J. Pharm. Tech. Res., 6: 737-751.
  21. Shahana, S. Shabana, G. Hundekari, M. Saifuddin, A.G. Nikalje and S.A. Yousuf, 2015. Comparative study of hypoglycemic effects and antioxidant potential of polyherbal formulation in alloxan induced diabetic rats an alternative therapeutic agent for diabetes management. Int. J. Pharm. Sci. Res., 6: 4381-4390.
  22. Nimbalkar, U.D., A.P. Nikalje, P.D. Netankar and D.L. Lingampalle, 2015. Ionic liquid mediated synthesis of 5-arylidine-2,4-thiazolidinediones and antibacterial evaluation. J. Med. Chem. Drug Discovery, 44: 331-342.
  23. Nikaljea, A.P., 2015. Synthesis,biological activity and docking study of novelisatin coupl edthiazolidin-4-one derivatives asanticonvulsants. Arch. Pharm. Chem. Life Sci. 348: 1-13.
  24. Nikalje, A.P.G., S.I. Shaikh, F.A.K. Khan, S. Shaikh and J.N. Sangshetti, 2015. Molecular sieves promoted, ultrasound-mediated synthesis, biological evaluation and docking study of 3-(5-substituted-1,3,4-thiadiazol-2-ylimino)indolin-2-ones as a potential anticonvulsant agents. Med. Chem. Res., 24: 4058-4069.
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  25. Nikalje, A.P.G., G. Gaikawad, R. Nawle, J. Sangshetti and F.A. Khan, 2015. Synthesis, pharmacological evaluation and docking study of novel 3-phenyl-5-aryl-4, 5-dihydro-1h-pyrazole-1- carbaldehyde asanti-inflammatory agents. Res. J. Pharm. Biol. Chem. Sci., 6: 423-431.
  26. Nikalje, A.P., N. Hirani and R. Nawle, 2015. Facile and eco-friendly microwave assisted synthesisof2-(3-(2-(1,3-dioxoisoindolin-2-yl)acetamido)-4-oxo-2-substitutedthiazolidin-5-yl) acetic acid as anti-inflammatory agents. Afr. J. Pharm. Pharmacol., 97: 209-222.
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  27. Nikalje, A.P., 2015. Nanotechnology and its applications in medicine. Med. Chem., 5: 081-089.
  28. Nikalje, A.G., M. Ghodke, F.A. Khan and J.N. Sangshetti, 2015. CAN catalyzed one-pot synthesis and docking study of some novel substituted imidazole coupled 1, 2, 4-triazole-5-carboxylic acids as antifungal agents. Chinese Chem. Lett., 26: 108-112.
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  29. Nikalje, A. M.S. Baig, M.I. Anees and A. Qureshi, 2015. Simultaneous estimation of alogliptin and metformin from its tablet dosage form by area under curve and multicomponent uv spectrophotometric method. WJPPS., 4: 1329-1339.
  30. Rao, U.K. andA.P. Nikalje, 2014. Simultaneous determination of Valsartan and Hydrochlorothiazide in a tablet dosage form by liquid Chromatography. Afr. J. Pharm. Pharmacol., 8: 929-952.
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  31. Nikalje, A.P.G., A.N. Shaikh, S.I. Shaikh, F.A.K. Khan and J.N. Sangshetti et al., 2014. Microwave assisted synthesis and docking study of N-(2-oxo-2-(4-oxo-2-substituted thiazolidin-3ylamino)ethyl)benzamide derivatives as anticonvulsant agents. Bioorganic Med. Chem. Lett., 24: 5558-5562.
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  32. Nikalje, A.P.G. and S.I. Shaikh, 2014. Ultrasound-promoted synthesis of indole appended heyerocycles. World J. Pharm. pharmacol., 3: 1282-1302.
  33. Nikalje, A.P., S.I. Shaikh, A. Mulay, F.A.Khan, J.N Sangshetti and S. Shaikh, 2014. Ultrasound-assisted synthesis, anticonvulsant activity, and docking study of indole-appended thiazolidin-4-ones. Arch. Pharm., 347: 756-767.
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  34. Nikalje, A.P., M. Ghodke and M.S. Baig, 2014. 2-Azetidinone-A brief review. World J. Pharm. Pharm. Sci., 3: 2589-2625.
  35. Choudhari, V.P. and A.P.G. Nikalje, 2014. Development and validation of stability indicating lc-pda method for mycophenolate mofetil in presence of mycophenolic acid and its application for degradation kinetics and ph profile study. Adv. Chem., 2014: 9-9.
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  36. Bhosale, D.M. and A.P.G. Nikalje, 2014. Development and validation of rp-cation exchange chromatographic method for estimation of divalent metallic ions from bulk and pharmaceutical products. World J. Pharm. Pharm. Sci., 3: 472-486.
  37. Tazeen, K.A. and N.A. Pratima, 2013. Craniotomy: A novel tool for removal of brain tumor. Int. J. Res. Pharm. Sci 3: 16-35.
  38. Nikalje, A.P.G., M. Ghodke and S.Tiwari, 2013. Exploring potential of 1,5-benzothiazepines: A brief review. Asian J. Res. Chem., 6: 182-186.
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  39. Nikalje, A.P., M. Ajhar and O. Shaikh, 2013. HPTLC method development, validation for simultaneous determination of efavirenz, emtricitabine and tenofovir in combined tablet formulation and forced degradation studies. Am. J. Pharm Tech Res., .
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  40. Nikalje, A.P., B. Shraddha and S. Zibran, 2013. Review of ultra performance liquid chromatography and its applications. Int. J. Rese. Pharm. Sci., 3: 19-40.
  41. Nikalje, A.P. and M. Ghodke, 2013. One pot green synthesis of 2-aryl/heteryl-benzimidazole as anti-inflammatory agents. World J. Pharm. Pharm. Sci., 3: 1311-1322.
  42. Nikalje, A.P.GY., M. Patel, Y. Ranadeb , R. Deshpandeb and D. Rajani, 2012. Design and synthesis of novel N-substituted morpholino benzamide derivatives as antimicrobial agents. Der Pharm., 3: 462-469.
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  43. Nikalje, A.P.G., M. Pathana, A.S. Narute, M.S. Ghodke and D. Rajani, 2012. Synthesis and QSAR study of novel N-(3-chloro-2-oxo-4-substituted azetidin-1-yl) isonicotinamide derivatives as anti mycobacterial agents. Der. Pharm. Sin., 3: 229-238.
  44. Nikalje, A.P.G., M. Pathan, M. Ghodke and D. Rajani, 2012. Synthesis of novel N-(2-substituted 4-oxothiazolidin-3-yl) isonicotinamide derivatives as anti mycobacterial agents. Der Pharm. Sinica, 3: 488-493.
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  45. Nikalje, A.P.G., M. Ghodke and A. Girbane, 2012. Design and synthesis of novel diphenyl oxalamide and diphenyl acetamide derivatives as anticonvulsants. Archiv der Pharmazie, 345: 57-64.
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  46. Nikalje, A.P.G., D. Deshpand and H.D. Une, 2012. Facile synthesis and in vivo hypoglycemic activity of novel 2, 4- hiazolidinedione derivatives. Eur. J. Exp. Biol., 2: 343-353.
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  47. Nikalje, A.P.G. and B.U. Rao, 2012. Determination of furosemide and zonisamide as a drug substance and in dosage form by ion pair –reversed phase liquid chromatographic techniqu. J. Appl. Pharm. Sci., 2: 94-99.
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  48. Nikalje, A.P., Zibran and D. Bhosale, 2012. Design, synthesis and hypoglycemic activity of novel 2-(4-((2, 4-dioxothiazolidin-5-ylidene) methyl)-2-methoxy phenoxy)-n- substituted acetamide derivatives”, anna pratima g. nikalje, sagar choudhari and hemant une. Eur. J. Exp. Biol., 2: 1302-1314.
  49. Nikalje, A.P., S. Tiwari and S. Kamble, 2012. Mucoadhesive -as oral controlled gastro retentive drug delivery system. IJRPS., 2: 32-59.
  50. Nikalje, A.G., A. Altamash and M. Ghodke, 2012. Herbal anticonvulsant agents: A brief review. Int. J. Res. Pharm. Sci., 2: 1-13.
  51. Nikalje, A. and S. Gaffar, 2012. Design,synthesis and evaluation of novel indolylpyrimidine carbohydrazides as antifungal agents. Curr. Pharm. Res., 2: 612-619.
  52. Bhosale, D. and A.P.G. Nikalje, 2012. Development and validation of RP-Chromatography for simultaneous determination of paracetamol, caffeine, ergotamine and prochlorperazine in tablets. Asian J. Pharm. Sci., 7: 344-351.
  53. Zaheer, Z., M. Devdikar, andA.P.G. Nikalje, 2011. Stability indicating HPLC method for determination of tramadol hydrochloride in tablet dosage form. Inventi J. Analysis Q. assurance, 2: 57-59.
  54. Nikalje, A.P.G., M. Ghodke and A. Girbane, 2011. GABA modulating agents: A brief review. Asian J. Biol. Sci., 4: 201-220.
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  55. Nikalje, A.P.G., F.K. Khan and M. Ghodke, 2011. Design and synthesis of 2-(1, 3-dioxoisoindolin-2-yl)-N-(4-oxo-2-substitutedthiazolidin-3-yl) acetamide derivatives as potential anticonvulsant agents. Eur. J. Med. Chem., 46: 5448-5455.
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  56. Nikalje, A.P.G. and B.U. Rao, 2011. Determination of gliclazide in a tablet dosage form in the presence of metformin hydrochloride by ion pair – reversed phase liquid chromatographic technique. Afr. J. Pharm. Pharmacol., 5: 1331-1337.
  57. Nikalje, A.P., P. Malhotra and M. Ghodke, 2011. Ultrasound-promoted green synthesis and pharmacological screening of some novel 4-(3, 5-diaryl substituted)-4, 5-dihydro-1H-pyrazol-1-yl) benzene sulfonamide. Asian J. Res. Chem., 4: 1712-1716.
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  58. Nikalje, A.P., A.C. Tathe and M.S. Ghodke, 2011. Biocatalysis: A brief review. Asian J. Res. Chem., 4: 1355-1360.
  59. Nikalje, A.G. and P. Mudassar, 2011. Multidrug-resistant Mycobacterium tuberculosis: A brief review. Asian J. Biol. Sci., 4: 101-115.
  60. Nikalje, A.G. and D. Vyawahare, 2011. Facile green synthesis of 2, 4-substituted -2, 3- dihydro-1, 5 Benzothiazepine derivatives as novel anticonvulsant and central nervous system (CNS) depressant agents. A. J. P. Applied Chem., 12: 422-428.
  61. Choudhari, V.P. and A.P.G. Nikalje, 2011. Validated TLC method for simultaneous quantitation of atorvastatin, ezetimibe, and fenofibrate in bulk drug and formulations. Acta Chromatographica, 23: 267-280.
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  62. Vyawahare, D., and A.P. Nikalje, 2010. Efficient one pot green synthesis of 2-aryl/heteryl-benzothiazoles as anti-inflammatory agents. Asian J. Res. Chem., 3: 872-875.
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  63. Vyawahare, D., M. Ghodke and A.P. Nikalje, 2010. Green synthesis and pharmacological screening of novel 1, 5-benzothiazepines as CNS agents. Int. J. Pharm. Pharm. Sci., 2: 27-29.
  64. Rao, B.U. and A.P. Nikalje, 2010. Determination of glipizide, glibenlamide and glimeperide in a tablet dosage form in the presence of metformin hydrochloride by ion pair-reversed phase liquid chromatographic technique. J. Anal. Bioanal. Tech., 1: 1-5.
  65. Nikalje, A.P., S. Pattan and A. Mane, 2010. Microwave-assisted solvent free synthesis and biological evaluation of 2-(4-arylthiazol-2-yl-amino)-n-aryl acetamides. Asian J. Exp. Biol. Sci., 1: 344-351.
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  66. Malhotra, P., S. Pattan and A.P. Nikalje, 2010. Microwave assisted synthesis and antiinflammatory activity of 3, 5-diaryl substituted-2-pyrazolines. Int. J. Pharm. Pharm. Sci., 2: 21-26.
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  67. Choudhari, V.P. andA.P. Nikalje, 2010. Simultaneous estimation of atorvastatin, ezetimibe and fenofibrate in pharmaceutical formulation by RP-LC-PDA. Pharm. Anal. Acta, 10.4172/2153-2435.1000111.
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  68. Rao, B.U.D. and A.P. Nikalje, 2009. Stability- indicating HPLC method for the determination of efavirenz in bulk drug and in pharmaceutical dosage form. Afr. J. Pharm. Pharmacol., 3: 443-450.
  69. Pattan, S.R., R.L. Hullolikar, J.S. Pattan, B.P. Kapadnis and N.S. Dighe et al., 2009. Synthesis and evaluation of some new pyrazolo phenoxy acetic acid derivatves for their antitubercular activity. J. Pharm. Sci. Res., 1: 63-68.
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  70. Pattan, S.R., P. Kekare, A. Patil, B.S. Kittur and A. Nikalje, 2009. Studies on the synthesis of novel 2, 4-thiazolidinedione derivatives with antidiabetic activity. Iranian J. Pharm. Sci., 5: 225-230.
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  71. Pattan, S.R., K. Prajact, N.S. Dighe, S.B. Bhawar, N. Ana, P. Ashwini and M.B. Hole, 2009. Synthesis and evaluation of some new Thiazolidinedione derivatives for their antidiabetic activities. Asian J. Res. Chem., 2: 123-126.
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  72. Narute, A. and A.G. Nikalje, 2009. Quantitative structure-activity relationship of some substituted phenothiazine as anti-inflammatory agents. Organic Chem. Ind. J., .
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  73. Kategaonkar, A.H., D.M. Patel, B.P. tkar, V.P. Choudhari, B.S. Kuchekar and A.G. Nikalje, 2009. Spectrophotometric and stability indicating rp-hplc-pda method for simultaneous determination of finasteride and tamsulosin in combined tablet dosage form. Asian J. Res. Chem., 2: 414-419.
  74. Choudhari, V.P. and A.P.G. Nikalje, 2009. Stability-indicating HPTLC method for the determination of tamsulosin in pharmaceutical dosage forms. Chromatographia, 69: 1463-1467.
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  75. Choudhari, V.P and A.G. Nikalje, 2009. Stability-Indicating HPTLC method for the determination of tamsulosin in pharmaceutical dosage forms. Chromatographia, 10.1365/s10337-009-1060-9.
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  76. Ashok, N., A.P.G. Nikalje and M. Vidya, 2009. QSAR study on isonicotinoyl hyhrazones as anti mico bacterial agents. J. Global Pharm.Tech., .
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  77. Abhinit, M., M. Ghodke and N.A. Pratima, 2009. Exploring potential of 4-thiazolidinone: A brief review. Int. J. Pharm. Pharm. Sci., 1: 47-64.
  78. Zaheer, Z., M.N. Farooqui, A. A. Mangle and A.G. Nikalje, 2008. Stability-indicating high performance liquid chromatographic determination of atorvastatin calcium in pharmaceutical dosage form. Afr. J. Pharm. Pharmacol., 2: 204-210.
  79. Rao, B.U., D. Shinde and A.P. Nikalje, 2008. Stability indicating hplc method for the determination of telmisartan as bulk drug and in pharmaceutical dosage form. Int. J. Chem. Sci., 6: 975-981.
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  80. Fernandes, N., M.S. Nimdeo, V.P. Choudhar, R.R. Kulkarnia, V.V. Pandea and A.G. Nikalje, 2008. Dual wavelength and simultaneous equation spectrophotometric methods for estimation of atenolol and indapamide in their combined dosage form. Int. J. Chem. Sci., 6: 29-35.
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  81. Choudhari, V.P., M.H. Dehghan and A.G. Nikalje, 2008. Derivative and UV spectrophotometric methods for determination of zopiclone in bulk and pharmaceutical formulations. J. Pharm. Res., 7: 68-69.
  82. Shiradkar, M.R., M. Ghodake, K.G. Bothara, S.V. Bhandari and A. Nikalje et al., 2007. Synthesis and anticonvulsant activity of clubbed thiazolidinone–barbituric acid and thiazolidinone–triazole derivatives. Arkivoc, 14: 58-74.
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  83. Pattan, S.R., B.R. Natraj, V. Ramesh, A.D. Tarnalli and A.R. Bhat et al., 2007. Synthesis and evaluation of some indole and pyrazole derivatives for anti-inflammatory activities. Ind. Drugs Bombay, 44: 439-443.
  84. Nirmal, S.A., A.G. Nikalje, R.S. Jadhav and V.D. Tambe, 2007. Antihelmintic activity of martynia annua roots. Ind. Drugs, 44: 772-773.
  85. Nikalje, A.P.G. and V.P. Choudhari, 2007. Iso absorptive point and zero absorbance spectrophotometric methods for estimation of Nebivolol and Amlodipine in combination in tablet formulation. Int. J. Chem. Sci., 5: 396-402.
  86. Nikalje, A.P.G. and S.R. Pattan, 2007. Synthesisof New1,5-benzothiazepines as Potential CNS and CVS agents. Int. J. Chem. Sci., 5: 290-296.
  87. Ingle, R. and A.P. Nikalje, 2007. Synthesis and antimicrobial activity of new heteryl phenoxy propanes. Ind. J. Heterocycl. Chem., 17: 49-52.
  88. Choudhari, V.P., R.R. Kulkarni and A.G. Nikalje, 2007. Derivative and UV spectrophotometric methods for determination of lovastatin in bulk and pharmaceutical formulations. J. Pharm. Res., 6: 246-247.
  89. Chaudhari, V.P and A.P.G. Nikalje, 2007. Derivative and UV spectrophotometric methods for determination of Tolterodine in bulk and Tablet formulations. Int. J. Chem. Sci., 5: 2359-2359.
  90. Nikalje, A.P.G., D.B. Ingle and R.A. Mane, 2006. Synthesis of New 1, 5-benzothiazepines as prospective antimicrobial agents. Ind. J. Heterocycl. Chem., 15: 309-310.
  91. Nikalje, A.G., D.B. Ingle and R.A.Mane, 2006. Synthesis and antimicrobial activity ofnew4-hiazolidinonyl-1,5-benzothiazepines. Int. J. Chemi. Sci., 4: 145-150.
  92. Choudhari, V.P., R.R. Kulkarni and A.G. Nikalje, 2006. Derivative spectrophotometric method for estimation of amlodipin and nebivolol hydrochlo ride in combined tablet formulation. J. Pharm. Res., 5: 113-115.
  93. Nikalje, A.P.G., R.D. Ingle and R.A. Mane, 2003. Synthesis of chromonyl and thiochromonyl 1, 5-benzothiazepines as microbial agents. Ind. J. Hetero cyclic Chem., 13: 37-40.