Dr. Deepak Nihalani
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Dr. Deepak Nihalani

Assistant Professor
University of Pennsylvania, USA

Highest Degree
Ph.D. in Biotechnology from Punjabi University, Patiala, India

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Biography

Dr. Deepak Nihalani is currently working as Research Assistant Professor at University of Pennsylvania, USA. He has completed his Ph.D. in Biotechnology from Punjabi University, Patiala, India. His area of expertise includes Kidney, Kidney injury, Glomerulus, Podocytes, and Biochemistry. He has published 28 research articles in journals contributed as author/co-author.

Area of Interest:

Biomedical Sciences
100%
Kidney
62%
Glomerulus
90%
Podocytes
75%
Biochemistry
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
53
Abstracts
0

Selected Publications

  1. Arif, E., Y.S. Rathore, B. Kumari, F. Ashish and H.N. Wong, 2014. Slit diaphragm protein neph1 and its signaling: A novel therapeutic target for protection of podocytes against glomerular injury. J. Biol. Chem., 289: 9502-9518.
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  2. Nihalani, D. and K. Susztak,. 2013. Sirt1-Claudin-1 crosstalk regulates renal function. Nat. Med. 19: 1371-1372.
    CrossRef  |  PubMed  |  Direct Link  |  
  3. Arif, E., B. Kumari, M.C. Wagner, W. Zhou and L.B. Holzman et al., 2013. Myo1c is an unconventional myosin required for zebrafish glomerular development. Kidney Int., 84: 1154-1165.
    CrossRef  |  PubMed  |  Direct Link  |  
  4. Tiwari, A., J.J. Jung, S.M. Inamdar, D. Nihalani and A. Choudhury, 2012. The myosin motor Myo1c is required for VEGFR2 delivery to the cell surface and for angiogenic signaling. Am. J. Physiol. Heart Circ. Physiol., 304: H687-H696.
    Direct Link  |  
  5. Mallik, L., A. Ehtesham, P. Sharma, Y.S. Rathore and H.N. Wong et al., 2012. Solution structure of cytoplasmic domain of Neph1 using SAXS data analysis and molecular modeling. J. Biol. Chem., 287: 9441-9453.
    Direct Link  |  
  6. Johnstone, D.B., V. Shegokar, D. Nihalani, Y.S. Rathore and L Mallik et al., 2012. APOL1 null alleles from a rural village in India do not correlate with glomerulosclerosis. PLoS ONE, .
    PubMed  |  Direct Link  |  
  7. George, B., R. Verma, A.A. Soofi, P. Garg and J. Zhang et al., 2012. Crk1/2-dependent signaling is necessary for podocyte foot process spreading in mice. J. Clin. Invest., 10.1172/JCI60070.
    CrossRef  |  
  8. Furcht, C.M., A.M. Rojas, D. Nihalani and M.J. Lazzara, 2012. Diminished functional role and altered localization of shp2 in non-small cell lung cancer cells with EGFR-activating mutations. Oncogene, 32: 2346-2355.
    CrossRef  |  
  9. Garg, R., N. Peddada, A. Sagar, D. Nihalani and Ashish, 2011. Visual insight into how low pH alone can induce actin-severing ability in gelsolin under calcium-free conditions. J. Biol. Chem., 286: 20387-20397.
    CrossRef  |  PubMed  |  Direct Link  |  
  10. Arif, E., M.C. Wagner, D.B. Johnstone, H.N. Wong and B. George et al., 2011. Motor protein Myo1c is a podocyte protein that facilitates the transport of slit diaphragm protein Neph1 to the podocyte membrane. Mol. Cell. Biol., 31: 2134-2150.
    CrossRef  |  PubMed  |  Direct Link  |  
  11. Wagner, M.C., G. Rhodes, E. Wang, V. Pruthi and E. Arif et al., 2008. Ischemic injury to kidney induces glomerular podocyte effacement and dissociation of slit diaphragm proteins Neph1 and ZO-1. The J. Biol. Chem., 283: 35579-35589.
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  12. Nihalani, D., H. Wong, R. Verma and L.B. Holzman, 2007. Src family kinases directly regulate JIP1 module dynamics and activation. Mol. Cell. Biol., 27: 2431-2441.
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  13. Garg, P., R. Verma, D. Nihalani, D.B. Johnstone and L.B. Holzman, 2007. Neph1 cooperates with Nephrin to transduce a signal that induces actin polymerization. Mol. Cell. Biol., 27: 8698-8712.
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  14. Verma, R., I. Kovari, A. Soofi, D. Nihalani, K. Patrie and L.B. Holzman, 2006. Nephrin ectodomain engagement results in Src kinase activation, nephrin phosphorylation, Nck recruitment, and actin polymerization. J. Clin. Invest., 116: 1346-1359.
    CrossRef  |  PubMed  |  Direct Link  |  
  15. Oetjen, E., A. Lechleiter, R. Blume, D. Nihalani, L. Holzman and W. Knepel, 2006. Inhibition of membrane depolarisation-induced transcriptional activity of cyclic AMP response element binding protein (CREB) by the dual-leucine-zipper-bearing kinase in a pancreatic islet beta cell line. Diabetologia, 49: 332-342.
    CrossRef  |  PubMed  |  Direct Link  |  
  16. Oetjen, E., A. Lechleiter, R. Blume, D. Nihalani, L. Holzman, W. Knepel, 2005. Inhibition of membrane depolarisation-induced transcriptional activity of cyclic AMP response element binding protein (CREB) by the dual-leucine-zipper-bearing kinase in a pancreatic islet beta cell line. Diabetologia, 21: 1-11.
  17. Verma, R., B. Wharram, I. Kovari, R. Kunkel and D. Nihalani et al., 2003. Fyn binds to and phosphorylates the kidney slit diaphragm component nephrin. J. Biol. Chem., 278: 20716-20723.
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  18. Nihalani, D., H.N. Wong and L.B. Holzman, 2003. Recruitment of JNK to JIP1 and JNK-dependent JIP1 phosphorylation regulates JNK module dynamics and activation. J. Biol. Chem., 278: 28694-28702.
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  19. Cai, Y., M.S. Lechner, D. Nihalani, M.J. Prindle, L.B. Holzman and G.R. Dressler, 2002. Phosphorylation of Pax2 by the c-Jun N-terminal kinase and enhanced Pax2-dependent transcription activation. J. Biol. Chem., 277: 1217-1222.
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  20. Nihalani, D., D. Meyer, S. Pajni and L.B. Holzman, 2001. Mixed lineage kinase-dependent JNK activation is governed by interactions of scaffold protein JIP with MAPK module components. EMBO J., 20: 3447-3458.
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  21. Nihalani, D., S. Merritt and L.B. Holzman, 2000. Identification of structural and functional domains in mixed lineage kinase Dual leucine zipper-bearing kinase required for complex formation and Stress-activated protein kinase activation. J. Biol. Chem., 275: 7273-7279.
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  22. Merrit, S.E., M. Mata, D. Nihalani, C. Zhu, X. Hu and L.B. Holzman, 1999. The mixed lineage kinase DLK utilizes MKK-7 and not MKK-4 as substrate. J. Biol. Chem., 274: 10195-10202.
    CrossRef  |  
  23. Nihalani, D., R. Kumar, K. Rajagopal and G. Sahni, 1998. Role of the amino-terminal region of streptokinase in the generation of a fully functional plasminogen activator complex probed with synthetic peptides. Protein Sci., 7: 637-648.
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  24. Nihalani, D., G.P. Raghava and G. Sahni, 1997. Mapping of the plasminogen binding site of streptokinase with short synthetic peptides. Protein Sci., 6: 1284-1292.
    PubMed  |  
  25. Nihalani, D. and G. Sahni, 1995. Streptokinase contains two independent plasminogen-binding sites. Biochem. Biophys. Res. Commn., 217: 1245-1254.
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  26. Nihalani, D. and T. Satyanarayana, 1992. Isolation and characterizatiion of extracellular alkaline enzyme producing bacteria. Indian. J. Microbiol., 32: 443-449.
  27. Nihalani, D and T. Satyanarayana, 1992. Isolation and characterizatiion of extracellular alkaline enzyme producing bacteria. Indian J. Microbiol., 32: 443-449.