Dr. Utpal S. Tatu
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Dr. Utpal S. Tatu

Research Scientist
Indian Institute of Science, India

Highest Degree
Ph.D. in Microbiology from Indian Institute of Science, India

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Area of Interest:

Molecular Sciences
100%
Microbiology
62%
Biological Chemistry
90%
Proteomics
75%
Cell Biology
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
0
Abstracts
0

Selected Publications

  1. Nageshan, R.K., N. Roy, A.B. Hehl and U. Tatu, 2011. Post-transcriptional repair of a split heat shock protein 90 gene by mRNA trans-splicing. J. Biol. Chem., 286: 7116-7122.
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  2. Saraogi, V., P. Padmapriya, A. Paul, U. Tatu and V. Natarajan, 2010. Detection of malarial infection using optical tweezers. J. Biol. Optics. .
  3. Roy, N., R.K. Nageshan, R. Pallavi, H. Chakravarthy and S. Chandran et al., 2010. Proteomics of Trypanosoma evansi infection in rodents. PLoS One Vol., 5. 10.1371/journal.pone.0009796.t001.
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  4. Pallavi, R., P. Acharya, S. Chandran, J.P. Daily, U. Tatu, 2010. Chaperone expression profiles correlate with distinct physiological states of Plasmodium falciparum in malaria patients. Malar. J. Vol. 9. 10.1186/1475-2875-9-236.
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  5. Pallavi, R., N. Roy, R.K. Nageshan, P. Talukdar and S.R. Pavithra et al., 2010. Heat shock protein 90 as a drug target against protozoan infections: Biochemical characterization of Hsp90 from Plasmodium falciparum, Trypanosoma evansi and evaluation of its inhibitor as a candidate drug. J. Biol. Chem., 285: 37964-37975.
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  6. Aluru, S.V., A. Narayanasamy, S. Chandran, U. Tatu and S. Agarwal et al, 2010. Two dimensional electrophoretic analysis of human tears: Collection method in dry eye syndrome. Electrophoresis, 31: 3420-3427.
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  7. Widera, D., M.P. Peli-Gulli, P.A. Brianda, U. Tatu and D. Picard, 2009. The complementation of yeast with human or Plasmodium falciparum Hsp90 confers differential inhibitor sensitivities. Mol. Biochem. Parasitol., 164: 147-152.
    PubMed  |  Direct Link  |  
  8. Acharya, P., R. Pallavi, S. Chandran, H. Chakravarti and S. Middha et al., 2009. A glimpse into the clinical proteome of human malaria parasites Plasmodium falciparum and Plasmodium vivax. Proteomics Clin. Appl., 3: 1314-1325.
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  9. Selvaraj, S.R., V. Bhatia and U. Tatu, 2008. Oxidative folding and assembly with transthyretin are sequential events in the biogenesis of retinol binding protein in the Endoplasmic reticulum. Mol. Biol. Cell, 19: 5579-5592.
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  10. Sawarkar, R., N. Roy, S. Rao, S. Raman, S. Venketesh, K. Suguna and U. Tatu, 2008. Heat shock protein 90 regulates development in Dictyostelium discoideum. J. Mol. Biol., 383: 24-35.
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  11. Pesce, E.R., P. Acharya, U. Tatu, W.S. Nicoll, A. Shonhai, H.C. Hoppe and G.L. Blatch, 2008. The Plasmodium falciparum heat shock protein 40, PfJ4, associates with heat shock protein 70 and shows similar heat induction and localisation patterns. Int. J. Biochem. Cell Biol., 40: 2914-2926.
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  12. Neckers, L. and U. Tatu, 2008. Molecular chaperones in pathogen virulence: Emerging new targets for therapy. Cell Host Microbe, 4: 519-527.
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  13. Rajan, S.S., V. Srinivasan, M. Balasubramanyam and U. Tatu, 2007. Endoplasmic reticulum (ER) stress and diabetes. Indian J. Med. Res., 125: 411-424.
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  14. Pavithra, S.R., R. Kumar and U. Tatu, 2007. Systems analysis of chaperone networks in the malarial parasite Plasmodium falciparum. PLoS Comput. Biol. Vol., 3. doi:10.1371/journal.pcbi.0030168.
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  15. Kumar, R., S.R. Pavithra and U. Tatu, 2007. Three-dimensional structure of heat shock protein 90 from Plasmodium falciparum: Molecular modelling approach to rational drug design against malaria. J. Biosci., 32: 531-536.
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  16. Acharya, P., R. Kumar and U. Tatu, 2007. Chaperoning a cellular upheaval in malaria: Heat shock proteins in Plasmodium falciparum. Mol. Biochem. Parasitol., 153: 85-94.
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  17. Tatu, U., S. Jain and P.P. Priya, 2005. Whither genome research: Of man, mosquito and malaria. J. Biosci., 30: 567-571.
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  18. Krishna, T.R., S. Jain, U. Tatu and N. Jayaraman, 2005. Synthesis and biological evaluation of 3-amino-propan-1-ol based poly (ether imine) dendrimers. Tetrahedron, 61: 4281-4288.
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  19. Khachane, A., R. Kumar, S. Jain, S. Jain and G. Banumathy et al., 2005. Plasmo2D: An ancillary proteomic tool to aid identification of proteins from Plasmodium falciparum. J. Proteome Res., 4: 2369-2374.
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  20. Jain, S., A. Rajput, Y. Kumar, N. Uppuluri, A. Arvind and U. Tatu, 2005. Protoemic analysis of urinary protein markers for accurate prediction of diabetic kidney disorders. J. Assoc. Physicians India, 53: 513-520.
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  21. Pavithra, S.R., G. Banumathy, O. Joy, V. Singh and U. Tatu, 2004. Recurrent fever promotes Plasmodium falciparum development in human erythrocytes. J. Biol. Chem., 279: 46692-46699.
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  22. Kumar, Y., A. Khachane, M. Belwal, S. Das, K. Somsundaram and U. Tatu, 2004. ProteoMod: A new tool to quantitate protein post-translational modifications. Proteomics, 4: 1672-1683.
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  23. Ghanekar, Y., A. Chandrashaker, U. Tatu and S.S. Visweswariah, 2004. Glycosylation of the receptor guanylyl cyclase C: Role in ligand binding and catalytic activity. Biochem. J., 379: 653-663.
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  24. Pillai, B., J. Verma, A. Abraham, P. Francis and Y. Kumar et al., 2003. Whole genome expression profiles of yeast RNA polymerase II core subunit, Rpb4, in stress and nonstress conditions. J. Biol. Chem., 278: 3339-3346.
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  25. Kumar, Y., A. Chawala and U. Tatu, 2003. Heat shock protein 70 as a biomarker of heat stress in a simulated hot cockpit. Aviat. Space Environ. Med., 74: 711-716.
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  26. Kumar, Y. and U. Tatu, 2003. Stress protein flux during recovery from simulated ischemia: Induced heat shock protein 70 confers cytoprotection by suppressing JNK activation and inhibiting apoptotic cell death. Proteomics, 3: 513-526.
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  27. Banumathy, G., V. Singh, S.R. Pavithra and U. Tatu, 2003. Heat shock protein 90 function is essential for plasmodium falciparum growth in human erythrocytes. J. Biol. Chem., 278: 18336-18345.
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  28. Sanjay, R., Y. Kumar, K. Babu, S. Ballal and U. Tatu, 2002. Evaluation of the role of serum leptin in hemodialysis patients. Indian J. Nephrol., 12: 69-72.
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  29. Kumar, Y., N.R.V. Uppuluri, K. Babu, K. Phadke, P. Kumar, S. Ballal and U. Tatu, 2002. Proteomics of renal disorders: Urinary proteome analysis by two-dimensional gel electrophoresis and MALDI-TOF mass spectrometry, Curr. Sci., 82: 655-663.
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  30. Banumathi, G., V. Singh and U. Tatu, 2002. Host chaperones are recruited in membrane bound complexes by Plasmodium falciparum. J. Biol. Chem., 277: 3902-3912.
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  31. Kumar, Y. and U. Tatu, 2000. Induced-Hsp70 is in small, cytoplasmic complexes in a cell culture model of renal ischemia: A comparative study with heat shock. Cell Stress Chaperones, 5: 314-327.
    PubMed  |  Direct Link  |  
  32. Tatu, U. and A. Helenius, 1999. Interaction of newly synthesized apolipoprotein B with calnexin and calreticulin requires glucose trimming in the Endoplasmic reticulum. Biosci. Reports, 19: 189-196.
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  33. Mehta, G., D.S. Reddy, S.S. Ramesh and U. Tatu, 1999. Polycyclitols: Stereoselective synthesis of decalin and diquinane based polyols as potential glycomimetics. Tetrahedron Lett., 40: 9141-9144.
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  34. Tatu, U. and A. Helenius, 1997. Interaction between newly synthesized glycoproteins with calnexin and a network of resident chaperones in the Endoplasmic reticulum. J. Cell Biol., 136: 555-565.
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  35. Tatu, U., C. Hammond and A. Helenius, 1995. Folding and oligomerization of Influenza hemagglutinin in the ER and the intermediate compartment. EMBO J., 14: 1340-1348.
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  36. Tatu, U., I. Braakman and A. Helenius, 1993. Membrane glycoprotein folding, oligomerization and intracellular transport: Effects of dithiothreitol in living cells. EMBO J., 12: 2151-2157.
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  37. Helenius, A., U. Tatu, T. Marquardt and I. Braakman, 1993. Protein Folding in the Endoplasmic reticulum. In: Cell Biology and Biotechnology, Oka, M.S. and R.G. Rupp (Eds.). Springer Verlag, Berlin/Heidelberg, ISBN: 9780387979519, pp: 125-132.
  38. Tatu, U., S.K. Murthy and P.J. Vithayathil, 1990. Role of a disulfide cross-link in the conformational stability of a thermostable Xylanase. J. Protein Chem., 9: 641-646.
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