Dr. Satheesh Kumar Palaninathan
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Dr. Satheesh Kumar Palaninathan

Research Scientist
Texas A&M University, USA


Highest Degree
PostDoc. in Biophysics from Texas A&M University, USA

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Biography

I am currently a Research Scientist in the Department of Biochemistry and Biophysics at Texas A&M University, with more than 15 years of research experience in the field of biochemistry, structural biology and drug discovery and co authored 17+ peer reviewed research publications. I received my Ph.D in 2001 from the Centre for Advanced Study in Crystallography and Biophysics, University of Madras, funded by the senior research fellowship of CSIR. My Ph.D research work (ring-shaped oligonucleotide crystals) was highlighted for its novelty by the nature publishing group in Nature-News India January 2000. Following the completion of my graduate work, I joined Texas A&M University to work on three different interdisciplinary projects, and achieved vital breakthroughs in Human amyloidosis (7 publications, 200+ citations), Mycobacterium tuberculosis (4 publications) and Corona virus research (4 publications). I was awarded "The Award of Excellence in Research-2008" from Texas A&M University for my outstanding contribution to the research advancement of the department through designing innovative research projects, co-authoring 12+ highly cited research articles in protein structural biology and drug discovery, and mentoring numerous research students. I have also involved in the review process of articles published in international journals. I am an active editorial board member of International Journal of Biotechnology and Biochemistry (IJBB). I am an active member of American Chemical Society, New York Academy of Sciences, American Crystallographic Association and Indian biophysical Society.

Area of Interest:

Physics
100%
Biophysics
62%
Drug Delivery
90%
Polyatomic Molecules
75%
Physics Theories
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
17
Abstracts
0

Selected Publications

  1. Shetty, N.D., M.C. Reddy, S.K. Palaninathan, J.L. Owen and J.C. Sacchettini, 2010. Crystal structures of the apo and ATP bound Mycobacterium tuberculosis nitrogen regulatory PII protein. Protein Sci., (In Press). .
    PubMed  |  
  2. Chinnaswamy, S., A. Murali, H. Cai, G. Yi, S.K. Palaninathan and C.C. Kao, 2010. Conformations of the monomeric hepatitis C Virus RNA-dependent RNA polymerase. Virus Adaptat. Treatment, 2: 21-39.
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  3. Reddy, M.C., S.K. Palaninathan, J.B. Bruning, C. Thurman, D. Smith and J.C. Sacchettini, 2009. Structural insights into the mechanism of the allosteric transitions of Mycobacterium tuberculosis cAMP receptor protein. J. Biol. Chem., 284: 36581-36591.
    CrossRef  |  PubMed  |  Direct Link  |  
  4. Palaninathan, S.K., N.N. Mohamedmohaideen, E. Orlandini, G. Ortore and S. Nencetti et al., 2009. Novel transthyretin amyloid fibril formation inhibitors: Synthesis, biological evaluation and X-ray structural analysis. PLoS One, 4: e6290-e6290.
    CrossRef  |  PubMed  |  
  5. Palaninathan, S.K., N.N. Mohamedmohaideen, W.C. Snee, J.W. Kelly and J.C. Sacchettini, 2008. Structural insight into pH-induced conformational changes within the native human transthyretin tetramer. J. Mol. Biol., 382: 1157-1167.
    PubMed  |  Direct Link  |  
  6. Mohamedmohaideen, N.N., S.K. Palaninathan, P.M. Morin, B.J. Williams and M. Braunstein et al., 2008. Structure and function of the virulence-associated high-temperature requirement A of Mycobacterium tuberculosis. Biochemistry, 47: 6092-6102.
    PubMed  |  Direct Link  |  
  7. Chinnaswamy, S., I. Yarbrough, S.K. Palaninathan, C.T. Kumar and V. Vijayaraghavan et al., 2008. A locking mechanism regulates RNA synthesis and host protein interaction by the hepatitis C virus polymerase. J. Biol. Chem., 283: 20535-20546.
    CrossRef  |  PubMed  |  Direct Link  |  
  8. Bhardwaj, K., S.K. Palaninathan, J.M. Alcantara, L.L. Yi, L. Guarino, J.C. Sacchettini and C.C. Kao, 2008. Structural and functional analyses of the severe acute respiratory syndrome coronavirus endoribonuclease Nsp15. J. Biol. Chem., 283: 3655-3664.
    PubMed  |  Direct Link  |  
  9. Reddy, M.C., S.K. Palaninathan, N.D. Shetty, J.L. Owen, M.D. Watson and J.C. Sacchettini, 2007. High resolution crystal structures of Mycobacterium tuberculosis adenosine kinase: insights into the mechanism and specificity of this novel prokaryotic enzyme. J. Biol. Chem., 282: 27334-27342.
    CrossRef  |  Direct Link  |  
  10. Kang, H., K. Bhardwaj, Y. Li, S.K. Palaninathan and J. Sacchettini et al., 2007. Biochemical and genetic analyses of murine hepatitis virus Nsp15 endoribonuclease. J. Virol., 81: 13587-13597.
    CrossRef  |  Direct Link  |  
  11. Johnson, S.M., H.M. Petrassi, S.K. Palaninathan, N.N. Mohamedmohaideen and H.E. Purkey et al., 2005. Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation. J. Biol. Chem., 48: 1576-1587.
    CrossRef  |  PubMed  |  Direct Link  |  
  12. Werner, S.L., S.K. Palaninathan, J.C. Sacchettini and J.W. Kelly, 2004. Diflunisal analogues stabilize the native state of transthyretin. Potent inhibition of amyloidogenesis. J. Med. Chem., 47: 355-374.
    CrossRef  |  Direct Link  |  
  13. Purkey, H.E., S.K. Palaninathan, K.C. Kent, C. Smith and S.H. Safe et al., 2004. Hydroxylated polychlorinated biphenyls selectively bind transthyretin in blood and inhibit amyloidogenesis: Rationalizing rodent PCB toxicity. Chem. Biol., 11: 1719-1728.
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  14. Razavi, H., S.K. Palaninathan, E.T. Powers, R.L. Wiseman and H.E. Purkey et al., 2003. Benzoxazoles as transthyretin amyloid fibril inhibitors: Synthesis, evaluation and mechanism of action. Angew Chem. Int. Ed. Engl., 42: 2758-2761.
    CrossRef  |  PubMed  |  Direct Link  |  
  15. Green, N.S., S.K. Palaninathan, J.C. Sacchettini and J.W. Kelly, 2003. Synthesis and characterization of potent bivalent amyloidosis inhibitors that bind prior to transthyretin tetramerization. J. Am. Chem. Soc., 125: 13404-13414.
    CrossRef  |  Direct Link  |  
  16. Thiyagarajan, S., S.K. Palaninathan, S.S. Rajan and N. Gautham, 2002. Structure of d(TGCGCA)2 at 293 K: Comparison of the effects of sequence and temperature. Acta Crystallogr. D Biol. Crystallogr., 58: 1381-1384.
    CrossRef  |  Direct Link  |  
  17. Palaninathan, S.K. and N. Gautham, 1999. Unusual ring-shaped oligonucleotide crystals. Curr. Sci., 77: 1076-1078.
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