Hi, I am Satheesh Kumar Palaninathan, My LiveDNA is 91.308
 
   
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Dr. Satheesh Kumar Palaninathan
 
Highest Degree: PostDoc. in Biophysics from Texas A&M University, USA
 
Institute: Texas A&M University, USA
 
Area of Interest:
  •   Amyloid: Folding, Misfolding, Disease and Treatment
  •   Crystallography
  •   Drug Discovery
  •   Tuberculosis: Structural Genomics
 
URL: http://livedna.org/91.308
 
My SELECTED Publications
1:   Bhardwaj, K., S.K. Palaninathan, J.M. Alcantara, L.L. Yi, L. Guarino, J.C. Sacchettini and C.C. Kao, 2008. Structural and functional analyses of the severe acute respiratory syndrome coronavirus endoribonuclease Nsp15. J. Biol. Chem., 283: 3655-3664.
PubMed  |  Direct Link  |  
2:   Chinnaswamy, S., A. Murali, H. Cai, G. Yi, S.K. Palaninathan and C.C. Kao, 2010. Conformations of the monomeric hepatitis C Virus RNA-dependent RNA polymerase. Virus Adaptat. Treatment, 2: 21-39.
Direct Link  |  
3:   Chinnaswamy, S., I. Yarbrough, S.K. Palaninathan, C.T. Kumar and V. Vijayaraghavan et al., 2008. A locking mechanism regulates RNA synthesis and host protein interaction by the hepatitis C virus polymerase. J. Biol. Chem., 283: 20535-20546.
CrossRef  |  PubMed  |  Direct Link  |  
4:   Green, N.S., S.K. Palaninathan, J.C. Sacchettini and J.W. Kelly, 2003. Synthesis and characterization of potent bivalent amyloidosis inhibitors that bind prior to transthyretin tetramerization. J. Am. Chem. Soc., 125: 13404-13414.
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5:   Johnson, S.M., H.M. Petrassi, S.K. Palaninathan, N.N. Mohamedmohaideen and H.E. Purkey et al., 2005. Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation. J. Biol. Chem., 48: 1576-1587.
CrossRef  |  PubMed  |  Direct Link  |  
6:   Kang, H., K. Bhardwaj, Y. Li, S.K. Palaninathan and J. Sacchettini et al., 2007. Biochemical and genetic analyses of murine hepatitis virus Nsp15 endoribonuclease. J. Virol., 81: 13587-13597.
CrossRef  |  Direct Link  |  
7:   Mohamedmohaideen, N.N., S.K. Palaninathan, P.M. Morin, B.J. Williams and M. Braunstein et al., 2008. Structure and function of the virulence-associated high-temperature requirement A of Mycobacterium tuberculosis. Biochemistry, 47: 6092-6102.
PubMed  |  Direct Link  |  
8:   Palaninathan, S.K. and N. Gautham, 1999. Unusual ring-shaped oligonucleotide crystals. Curr. Sci., 77: 1076-1078.
Direct Link  |  
9:   Palaninathan, S.K., N.N. Mohamedmohaideen, E. Orlandini, G. Ortore and S. Nencetti et al., 2009. Novel transthyretin amyloid fibril formation inhibitors: Synthesis, biological evaluation and X-ray structural analysis. PLoS One, 4: e6290-e6290.
CrossRef  |  PubMed  |  
10:   Palaninathan, S.K., N.N. Mohamedmohaideen, W.C. Snee, J.W. Kelly and J.C. Sacchettini, 2008. Structural insight into pH-induced conformational changes within the native human transthyretin tetramer. J. Mol. Biol., 382: 1157-1167.
PubMed  |  Direct Link  |  
11:   Purkey, H.E., S.K. Palaninathan, K.C. Kent, C. Smith and S.H. Safe et al., 2004. Hydroxylated polychlorinated biphenyls selectively bind transthyretin in blood and inhibit amyloidogenesis: Rationalizing rodent PCB toxicity. Chem. Biol., 11: 1719-1728.
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12:   Razavi, H., S.K. Palaninathan, E.T. Powers, R.L. Wiseman and H.E. Purkey et al., 2003. Benzoxazoles as transthyretin amyloid fibril inhibitors: Synthesis, evaluation and mechanism of action. Angew Chem. Int. Ed. Engl., 42: 2758-2761.
CrossRef  |  PubMed  |  Direct Link  |  
13:   Reddy, M.C., S.K. Palaninathan, J.B. Bruning, C. Thurman, D. Smith and J.C. Sacchettini, 2009. Structural insights into the mechanism of the allosteric transitions of Mycobacterium tuberculosis cAMP receptor protein. J. Biol. Chem., 284: 36581-36591.
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14:   Reddy, M.C., S.K. Palaninathan, N.D. Shetty, J.L. Owen, M.D. Watson and J.C. Sacchettini, 2007. High resolution crystal structures of Mycobacterium tuberculosis adenosine kinase: insights into the mechanism and specificity of this novel prokaryotic enzyme. J. Biol. Chem., 282: 27334-27342.
CrossRef  |  Direct Link  |  
15:   Shetty, N.D., M.C. Reddy, S.K. Palaninathan, J.L. Owen and J.C. Sacchettini, 2010. Crystal structures of the apo and ATP bound Mycobacterium tuberculosis nitrogen regulatory PII protein. Protein Sci., (In Press). .
PubMed  |  
16:   Thiyagarajan, S., S.K. Palaninathan, S.S. Rajan and N. Gautham, 2002. Structure of d(TGCGCA)2 at 293 K: Comparison of the effects of sequence and temperature. Acta Crystallogr. D Biol. Crystallogr., 58: 1381-1384.
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17:   Werner, S.L., S.K. Palaninathan, J.C. Sacchettini and J.W. Kelly, 2004. Diflunisal analogues stabilize the native state of transthyretin. Potent inhibition of amyloidogenesis. J. Med. Chem., 47: 355-374.
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