Dr. Syam Mohan Murali Mohan

Dr. Syam Mohan Murali Mohan

Associate Professor
University of Jazan, Saudi Arabia


Highest Degree
Ph.D. in Pharmacology from Universiti Putra Malaysia, Malaysia

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Area of Interest:

Pharmacology and Toxicology
100%
Cancer
62%
Pharmacology
90%
Cell Biology
75%
Molecular Sciences
55%

Education

2010

Ph.D.

Universiti Putra Malaysia, Malaysia

Pharmacology

Selected Publications

  1. Syam, S., A. Bustamam, R. Abdullah, M.A. Sukari and N.M. Hashim et al., 2013. Β-Mangostin induces p53-dependent G2/M cell cycle arrest and apoptosis through ROS mediated mitochondrial pathway and NfkB suppression in MCF-7 cells. J. Funct. Foods. 10.1016/j.jff.2013.10.018.
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  2. Sidahmed, H.M.A., S.I. Abdelwahab, S. Mohan, M.A. Abdulla, M.M.E. Taha, N.M. Hashim and A.H.A. Hadi et al., 2013. α-Mangostin from Cratoxylum arborescens (Vahl) blume demonstrates anti-ulcerogenic property: A mechanistic study. Evidence-Based Complement. Altern. Med., Vol. 2013. 10.1155/2013/450840.
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  3. Sidahmed, H.M., N.M. Hashim, J. Amir, M.A. Abdulla and A.H. Hadi et al., 2013. Pyranocycloartobiloxanthone A, a novel gastroprotective compound from Artocarpus obtusus Jarret, against ethanol-induced acute gastric ulcer in vivo. Phytomedicine, 20: 834-843.
    CrossRef  |  PubMed  |  

  4. Sidahmed, H.M., A.H. Azizan, S. Mohan, M.A. Abdulla and S.I. Abdelwahab et al., 2013. Gastroprotective effect of desmosdumotin C isolated from Mitrella kentia against ethanol-induced gastric mucosal hemorrhage in rats: Possible involvement of glutathione, heat-shock protein-70, sulfhydryl compounds, nitric oxide and anti-Helicobacter pylori activity. BMC Complement. Altern. Med., Vol. 13. 10.1186/1472-6882-13-183.
    CrossRef  |  PubMed  |  

  5. Salim, L.Z.A., S. Mohan, R. Othman, S.I. Abdelwahab, B. Kamalidehghan, B.Y. Sheikh and M.Y. Ibrahim, 2013. Thymoquinone induces mitochondria-mediated apoptosis in acute lymphoblastic leukaemia in vitro. Molecules, 18: 11219-11240.
    CrossRef  |  Direct Link  |  

  6. Nadzri, N.M., A.B. Abdul, M.A. Sukari, S.I. Abdelwahab and E.E. Eid et al., 2013. Inclusion complex of zerumbone with hydroxypropyl-β-Cyclodextrin Induces apoptosis in liver hepatocellular HepG2 cells via caspase 8/BID cleavage switch and modulating Bcl2/Bax ratio. Evidence-Based Complement. Altern. Med. 10.1155/2013/810632.
    CrossRef  |  

  7. Isa, N.M., A.B. Abdul, S.I. Abdelwahab, R. Abdullah, M.A. Sukari, B. Kamalidehghan and A.H.A. Hadi et al., 2013. Boesenbergin A, a chalcone from Boesenbergia rotunda induces apoptosis via mitochondrial dysregulation and cytochrome c release in A549 cells in vitro: Involvement of HSP70 and Bcl2/Bax signalling pathways. J. Funct. Foods, 5: 87-97.
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  8. Ibrahim, M.Y., N.M. Hashim, S. Mohan, M.A. Abdulla and S.I. Abdelwahab et al., 2013. α-Mangostin from cratoxylum arborescens: An in vitro and in vivo toxicological evaluation. Arabian J. Chem. 10.1016/j.arabjc.2013.11.017.
    CrossRef  |  

  9. Arbab, I.A., A.B. Abdul, M.A. Sukari, R. Abdullah and S. Syam et al., 2013. Dentatin isolated from Clausena excavata induces apoptosis in MCF-7 cells through the intrinsic pathway with involvement of NF-κB signalling and G0/G1 cell cycle arrest: A bioassay-guided approach. J. Ethnopharmacol., 145: 343-354.
    CrossRef  |  Direct Link  |  

  10. Syam, S., S.I. Abdel-wahab, M.A. Al-Mamary and S. Mohan, 2012. Synthesis of chalcones with anticancer activities. Molecules, 17: 6179-6195.
    CrossRef  |  PubMed  |  

  11. Samuel, A.J., S. Mohan, D.K. Chellappan, A. Kalusalingam and S. Ariamuthu, 2012. Hibiscus vitifolius (Linn.) root extracts shows potent protective action against anti-tubercular drug induced hepatotoxicity. J. Ethnopharmacol., 141: 396-402.
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  12. Mohan, S., S.I. Abdelwahab, B. Kamalidehghan, S. Syam and K.S. May et al., 2012. Involvement of NF-κB and Bcl2/Bax signaling pathways in the apoptosis of MCF7 cells induced by a xanthone compound Pyranocycloartobiloxanthone A. Phytomedicine, 19: 1007-1015.
    CrossRef  |  PubMed  |  Direct Link  |  

  13. Isa, N.M., S.I. Abdelwahab, S. Mohan, A.B. Abdul and M.A. Sukari et al., 2012. In vitro anti-inflammatory, cytotoxic and antioxidant activities of boesenbergin A, a chalcone isolated from Boesenbergia rotunda (L.) (fingerroot). Braz. J. Med. Biol. Res., 45: 524-530.
    PubMed  |  

  14. Arya, A., A.M. Mohd, M. Achoui, S.C. Cheah and S. Mohan et al., 2012. Chloroform fraction of Centratherum anthelminticum (L.) seed inhibits tumor necrosis factor alpha and exhibits pleotropic bioactivities: Inhibitory role in human tumor cells. Evidence-Based Complement. Altern. Med., 10.1155/2012/627256.
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  15. Arbab, I.A., C.Y. Looi, A.B. Abdul, F.K. Cheah and W.F. Wong et al., 2012. Dentatin induces apoptosis in prostate cancer cells via Bcl-2, Bcl-xL, survivin downregulation, caspase-9, -3/7 activation and NF-κB inhibition Evidence-Based Complement. Altern. Med. 10.1155/2012/856029.
    CrossRef  |  Direct Link  |  

  16. Arbab, I.A., A.B. Abdul, M. Aspollah, R. Abdullah, S.I. Abdel-Wahab, S. Mohan and A.H.A. Abdelmageed, 2012. Clausena excavate Burm. f. (Rutaceae): A review of its traditional uses, pharmacological and phytochemical properties. J. Med. Plants Res., 5: 7177-7184.

  17. Abdel-Wahab, S.I., W.S. Koko, M.M.E. Taha, S. Mohan, M. Achoui and M.A. Abdulla et al., 2012. In vitro and in vivo anti-inflammatory activities of columbin through the inhibition of cycloxygenase-2 and nitric oxide but not the suppression of NF-κB translocation. Eur. J. Pharmacol., 678: 61-70.
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  18. Abdel-Wahab, S.I., L.E.A. Hassan, A.M. Abdul Majid, S.M. Yagi and S. Mohan et al., 2012. Cucurbitacin L 2-O-β-Glucoside demonstrates apoptogenesis in colon adenocarcinoma Cells (HT-29): Involvement of reactive oxygen and nitrogen species regulation. Evidence-Based Complement. Altern. Med. 10.1155/2012/490136.
    CrossRef  |  PubMed  |  

  19. Abdel-Wahab, S.I., A.W.H. Mohamed, O.Y. Mohamed, M. Oall and M.M.E. Taha et al., 2012. Erectogenic effects of Clerodendron capitatum: Involvement of phosphodiesterase type-5 inhibition. Evidence-Based Complement. Altern. Med. 10.1155/2012/137386.
    CrossRef  |  Direct Link  |  

  20. Syam, S., A.B. Abdul, M.A. Sukari, S. Mohan and S.I. Abdelwahab et al., 2011. Growth suppressing effect of girinimbine in HepG2 involves induction of apoptosis and cell cycle arrest. Molecules, 16: 7155-7170.
    PubMed  |  

  21. Mohan, S., A. Bustamam, S.I. Abdel-Wahab, A.S. Al-Zubairi, M. Aspollah, R. Abdullah and M.M. Elhassan, 2011. In vitro ultramorphological assessment of apoptosis on CEMss induced by linoleic acid-rich fraction from Typhonium flagelliforme tuber. Evidence-Based Complement. Altern. Med. 10.1093/ecam/neq010.
    CrossRef  |  PubMed  |  Direct Link  |  

  22. Mariod, A.A., S.I. Abdel-Wahab, M.Y. Ibrahim, S. Mohan, M. Abd-Elgadir and N.M. Ain, 2011. Preparation and characterisation of gelatins from two sudanese edible insects. J. Food Sci. Eng., 1: 45-55.

  23. Abdelwahab, S.I., S. Mohan, M.M. Elhassan, N. Al-Mekhlafi and A.A. Mariod et al., 2011. Antiapoptotic and antioxidant properties of Orthosiphon stamineus Benth (Cat's whiskers): Intervention in the Bcl-2-mediated apoptotic pathway. Evidence-Based Complement. Altern. Med. 10.1155/2011/156765.
    CrossRef  |  Direct Link  |  

  24. Abdelwahab, S.I., S. Mohan, M.A. Abdulla, M.A. Sukari and A.B. Abdul et al., 2011. The methanolic extract of Boesenbergia rotunda (L.) Mansf. and its major compound inostrobin induces anti-ulcerogenic property in vivo: Possible involvement of indirect antioxidant action. J. Ethnopharmacol., 137: 963-970.
    PubMed  |  

  25. Abdelwahab, S.I., A.B. Abdul, S. Mohan, M.M.E. Taha, S. Syam, M.Y. Ibrahim and A.A. Mariod, 2011. Zerumbone induces apoptosis in T-acute lymphoblastic leukemia cells. Leukemia Res., 35: 268-271.
    CrossRef  |  PubMed  |  Direct Link  |  

  26. Abdel-Wahab, S.I., S. Mohan, M.A. Abdulla, M.A. Sukari and A.B. Abdul et al., 2011. The methanolic extract of Boesenbergia rotunda (L.) Mansf. and its major compound pinostrobin induces anti-ulcerogenic property in vivo: Possible involvement of indirect antioxidant action. J. Ethnopharmacol., 137: 963-970.
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  27. Abdel-Wahab, S.I., L.E. Hassan, H.M. Sirat, S.M. Yagi and W.S. Koko et al., 2011. Anti-inflammatory activities of cucurbitacin E isolated from Citrullus lanatus var. citroides: Role of reactive nitrogen species and cyclooxygenase enzyme inhibition. Fitoterapia, 82: 1190-1197.
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  28. Taha, M.M.E., A.B. Abdul, R. Abdullah, T.A.T. Ibrahim, S.I. Abdelwahab and S. Mohan, 2010. Potential chemoprevention of diethylnitrosamine-initiated and 2-acetylaminofluorene-promoted hepatocarcinogenesis by zerumbone from the rhizomes of the subtropical ginger (Zingiber zerumbet). Chem. Biol. Interact., 186: 295-305.
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  29. Sekharan, T.R., S. Mohan, R. Venkatnarayanan and A.T. Thirupathi, 2010. Pharmacognostical and preliminary phytochemical screening the leaves of Jasminum grandiflorum Linn. Res. J. Pharm. Phytochem., 2: 438-440.

  30. Mohan, S., A.B. Abdul, S.I. Abdel-Wahab, A.S. Al-Zubairi, M.A. Sukari and R, Abdullah et al., 2010. Typhonium flagelliforme inhibits the proliferation of murine leukemia WEHI-3 cells in vitro and induces apoptosis in vivo. Leukemia Res., 34: 1483-1492.
    CrossRef  |  PubMed  |  Direct Link  |  

  31. Mohan, S., A. Bustamam, S.I. Abdel-Wahab, M. Mohamed and N. Beng et al., 2010. Typhonium flagelliforme induces apoptosis through mitochondrial pathway. Eur. J. Cancer Suppl., 8: 83-154.

  32. Mohan, S., A. Bustamam, S.I. Abdel-Wahab, A.S. Al- Zubairi and M. Aspollah et al., 2010. Typhonium flagelliforme induces apoptosis in CEMss cells via activation of caspase-9, PARP cleavage and cytochrome C release: Its activation coupled with G0/G1 phase cell cycle arrest. J. Ethnopharmacol., 131: 592-600.
    CrossRef  |  PubMed  |  Direct Link  |  

  33. Ibrahim. M.Y., A.B.H. Abdul, T.A.T. Ibrahim, S.I.A. Wahab and M.M. El-Hassan et al., 2010. Evaluation of acute toxicity and the effect of single injected doses of zerumbone on the kidney and liver functions in Sprague Dawley rats. Afr. J. Biotechnol., 9: 4442-4450.
    Direct Link  |  

  34. Ibrahim. M.Y., A.B.H. Abdul, T.A.T. Ibrahim, S.I. AbdelWahab, M.M. Elhassan and S. Mohan, 2010. Attenuation of cisplatin-induced nephrotoxicity in rats using zerumbone. Afr. J. Biotechnol., 9: 4434-4441.
    Direct Link  |  

  35. Al-Zubairi, A.S., A.B. Abdul, M. Yousif, S.I. Abdelwahab, M.M. Elhassan and S. Mohan, 2010. In vivo and in vitro genotoxic effects of zerumbone. Caryologia, 63: 11-17.
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  36. Al-Zubairi, A.S., A.B. Abdul and M.M. Syam, 2010. Evaluation of the genotoxicity of zerumbone in cultured human peripheral blood Lymphocytes. Toxicol In vitro, 24: 707-712.
    CrossRef  |  PubMed  |  Direct Link  |  

  37. Abdel-Wahab, S.I., A.B. Abdul, N. Devi, M.M.E. Taha and A.S. Al-Zubairi et al., 2010. Regression of cervical intraepithelial neoplasia by zerumbone in female Balb/c mice prenatally exposed to diethylstilboestrol: Involvement of mitochondria-regulated apoptosis. Exp. Toxicol. Pathol., 62: 461-469.
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  38. Sunilson, J.A.J., K. Anandarajagopal, A.V.A.G. Kumari and S. Mohan, 2009. Antidiarrhoeal activity of leaves of Melastoma malabathricum Linn. Indian J. Pharmaceut. Sci., 71: 691-695.
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  39. Siddig, I.A., B.A. Ahmad, A.S. Al-Zubairi, M.E.T. Manal and S. Mohan et al., 2009. Biological activities of peresika bleo extracts. Int. J. Pharmacol., 5: 71-75.
    Direct Link  |  

  40. Ibrahim, M.Y., A.B. Abdul, S.I. Abdel Wahab, M.M. Elhassan, A.S. Alzubairi and M.M. Syam, 2009. Attenuation of cisplatin-induced hepatotoxicity in rats using zerumbone. Res. J. Biol. Sci., 4: 777-784.
    CrossRef  |  Direct Link  |  

  41. Al-Zubairi, A.S., A.B. Abdul, S.I.A. Wahab, C.Y. Peng and S. Mohan et al., 2009. Eleucine indica possesses antioxidant, antibacterial and cytotoxic properties. Evidence-Based Complement. Altern. Med. 10.1093/ecam/nep091.
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  42. Abdul, A.B., S.I. Abdel-Wahab, H.K. Fong, S.M. Mohan, A.S. Al-Zubairi and M.M. Elhassan, 2009. In vitro response of cancer cells to the growth inhibitory effects of Dichloromethane extract of Goniothalamus umbrosus. Res. J. Pharmacol., 3: 1-6.
    Direct Link  |  

  43. Abdul, A., S.I.A. Wahab, H. Fong, S. Mohan and A. Al- Zubairi et al., 2009. In vitro response of cancer cells to the growth-inhibitory effects of dichloromethane extract of Goniothalamus umbrosus. Res. J. Pharmacol., 3: 1-6.
    CrossRef  |  Direct Link  |  

  44. Abdel-Wahab, S.I., A.B. Abdul, S.M. Mohan, A.S. Al-Zubairi, M.M. Elhassan and M.Y. Ibrahim, 2009. Biological activities of Pereskia bleo extracts. Int. J. Pharmacol., 5: 71-75.
    CrossRef  |  Direct Link  |  

  45. Abdel-Wahab, S.I., A.B. Abdul, S.M. Mohan, A.S. Al-Zubairi and M.M. Elhassan, 2009. Oncolysis of breast, liver and leukemia cancer cells using ethyl acetate and methanol extracts of Goniothalamus umbrosus. Res. J. Biol. Sci., 4: 209-215.
    Direct Link  |  

  46. Abdel-Wahab, S.I., A.B. Abdul, M.M. El-Hassan, S. Mohan and M.Y. Ibrahim et al., 2009. GC/MS determination of bioactive components and antibacterial properties of Goniothalamus umbrosus extracts. Afr. J. Biotechnol., 8: 3336-3340.
    Direct Link  |  

  47. Abdel-Wahab, S.I., A.B. Abdul, H.K. Fong, S. Mohan, M.M. Elhassan, A.S. Al-Zubairi and A.A. Mariod, 2009. Antimicrobial and free radical scavenging activities of the dichloromethane extract of Goniothalamus umbrosus. Int. J. Trop. Med., 4: 32-36.
    Direct Link  |  

  48. Abdel-Wahab, S.I., A.B. Abdul, A.S. Al-Zubairi, M.M. Elhassan and M. Syam, 2009. In vitro ultramorphological assessment of apoptosis induced by zerumbone on (Hela). J. Biomed. Biotechnol. 10.1155/2009/769568.
    CrossRef  |  PubMed  |  Direct Link  |  

  49. Sunilson, J., J. Anbu, P. Jayaraj, S. Mohan, A.G. Kumari and R. Varatharajan, 2008. Antioxidant and hepatoprotective effect of the roots of Hibiscus esculentus Linn. Int. J. Green Pharm., 2: 200-203.
    Direct Link  |  

  50. Sunilson, A.J., S. Mohan, M.A. Mohamed, J. Thomas and A.G. Kumari, 2008. Antitumour activity of Hibiscus tiliaceus Linn. Roots. Iran. J. Pharmacol. Ther., 7: 123-125.
    Direct Link  |  

  51. Sunilson, A.J., M.S. Muthu, S. Mohan, A.A.G. Kumari and J. Thomas et al., 2008. Antidiabetic activity of momordica tuberosa (Roxb.) cogn Tuber extracts. Int. J. Pharm. Biol. Sci., 2: 41-45.

  52. Mohan, S., A.B. Abdul, S.I.A. Wahab, A.S. Al-zubairi and M.M. El-Hassan et al., 2008. Antibacterial and antioxidant activities of Typhonium flagelliforme (Lodd.) blume leaves. Res. J. Pharmacol., 2: 47-51.

  53. Mohan, S., A.B. Abdul, S.I. Abdel-Wahab, A.S. Al-Zubairi, M.M. Elhassan and M. Yousif, 2008. Antibacterial and antioxidant activities of Typhonium flagelliforme (Lodd.) blume tuber. Am. J. Biochem. Biotechnol., 4: 402-407.
    CrossRef  |  Direct Link  |  

  54. Mohan, S., A. Bustamam, S.I. Abdel-Wahab, A.S. Al-Zubairi and M. Aspollah, 2008. Anticancerous effect of Typhonium flagelliforme on human t4-lymphoblastoid cell line CEM-ss. J. Pharmacol. Toxicol., 3: 449-456.
    CrossRef  |  Direct Link  |  

  55. Bustamam, A., S. Ibrahim, N. Devi, M.N. Halkim, A.S. Al-Zubairi and M.M. Syam, 2008. The establishment and use of an in vivo animal model for cervical intra-epithelial neoplasia. Int. J. Cancer Res., 4: 61-70.
    CrossRef  |  Direct Link  |  

  56. Bustamam, A., S. Ibrahim, A.S. Al-Zubairi, M.E.T. Manal and S. Mohan, 2008. Zerumbone: A natural compound with anti-cholinesterase activity. Am. J. Pharma. Toxicol., 3: 209-211.
    CrossRef  |  Direct Link  |  

  57. Abdul, A.B.H., A.S. Al-Zubairi, N.D. Tailan, S.I. Abdel-Wahab, Z.N.M. Zain, S. Ruslay and M.M. Syam, 2008. Anticancer activity of natural compound (Zerumbone) extracted from Zingiber zerumbet in human hela cervical cancer cells. Int. J. Pharmacol., 4: 160-168.
    CrossRef  |  Direct Link  |  

  58. Abdul, A.B., S.I. Abdel-Wahab, A.S. Al-Zubairi, M.M. El-Hassan and S.M. Murali, 2008. Anticancer and antimicrobial activities of zerumbone from the rhizomes of Zingiber zerumbut. Int. J. Pharmacol., 4: 301-304.
    CrossRef  |  Direct Link  |  

  59. Abdel-Wahab, S.I., A.B. Abdul, H.C. Yee, A.S. Alzubairi, M.M. ElHassan and M.M. Syam, 2008. Anti-tumor activities of analogues derived from the bioactive compound of Zingiber zerumbet. Int. J. Cancer Res., 4: 154-159.
    CrossRef  |  Direct Link  |  

  60. Sunilson, A.J., R. Venkatanarayanan, A. Thangathirupathi, M. Prabha and S. Mohan et al., 2004. Wound healing activity of jasminum sambac leaf extract. Adv. Pharmacol. Toxicol., 5: 45-49.