Dr. Rakesh Kumar Tiwari

Dr. Rakesh Kumar Tiwari

Assistant Professor
Chapman University, USA


Highest Degree
Ph.D. in Organic Chemistry from University of Delhi, India

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Area of Interest:

Chemistry
100%
Peptide Chemistry
62%
Efficient Drug Delivery
90%
Medicinal Chemistry
75%
Organic Chemistry
55%

Education

2006

Ph.D.

University of Delhi, India

Organic Chemistry

Selected Publications

  1. Motavallizadeh, S., A. Fallah-Tafti, S. Maleki, A.N. Shirazi and M. Pordeli et al., 2014. Synthesis and evaluation of cytotoxic activity of substituted N-(9-oxo-9H-xanthen-4- Tetrahedron Lett., 55: 373-375.

  2. Verma, A.K., S.K.R. Kotla, T. Aggarwal, S. Kumar, H. Nimesh and R.K. Tiwari, 2013. Tandem synthesis of pyrroloacridones via [3+2] alkyne annulation/ring-opening with concomitant intramolecular aldol condensation. J. Org. Chem., 78: 5372-5384.
    CrossRef  |  

  3. Verma, A.K., S.K.R. Kotla, D. Chaudhary, M. Patel and R.K. Tiwari, 2013. Silver-catalyzed tandem synthesis of naphthyridines and thienopyridines via three-component reaction. J. Org. Chem., 78: 4386-4401.
    CrossRef  |  

  4. Verma, A.K., R.R. Jha, R. Chaudhary, R.K. Tiwari and A. Danodia, 2013. 2-(1-Benzotriazolyl)pyridine: A robust bidentate ligand for the palladium-catalyzed C-C, (suzuki, heck, oxidative-heck, sonogashira), C-N and C-S coupling reactions. Adv. Synth. Catal., 355: 421-438.

  5. Verma, A.K., M. Patel, M. Joshi, P.R. Likhar, R.K. Tiwari and K. Parang, 2013. Base-mediated chemo- and stereoselective addition of 5-aminoindole/tryptamine and histamines onto alkynes. J. Org. Chem.,. 10.1021/jo402352v.
    CrossRef  |  

  6. Shirazi, A.N., R.K. Tiwari, D. Oh, B. Sullivan, K. McCaffrey, D. Mandal and K. Parang, 2013. Surface decorated gold nanoparticles by linear and cyclic peptides as molecular transporters. Mol. Pharm., 10: 3137-3151.
    CrossRef  |  

  7. Shirazi, A.N., R.K. Tiwari, D. Oh, A. Banerjee, A. Yadav and K. Parang, 2013. Efficient delivery of cell impermeable phosphopeptides by a cyclic peptide amphiphile containing tryptophan and arginine. Mol. Pharm., 10: 2008-2020.
    CrossRef  |  

  8. Shirazi, A.N., R.K. Tiwari, B.S. Chhikara, D. Mandal and K. Parang, 2013. Design and biological evaluation of cell-penetrating peptide-doxorubicin conjugates as prodrugs. Mol. Pharm., 10: 488-499.
    CrossRef  |  

  9. Shirazi, A.N., R.K. Tiwari, A. Brown, D. Mandal, G. Sun and K. Parang, 2013. Cyclic peptides containing tryptophan and arginine as Src kinase inhibitors. Bioorg. Med. Chem. Lett., 23: 3230-3234.
    CrossRef  |  

  10. Shirazi, A.N., D. Oh, R.K. Tiwari, B. Sullivan, A. Gupta, G. Bothun and K. Parang, 2013. Peptide amphiphile containing arginine and fatty acyl chains as molecular transporters. Mol. Pharm., 10: 4717-4727.
    CrossRef  |  

  11. Shirazi, A.N., D. Mandal, R.K. Tiwari, L. Guo, W. Lu and K. Parang, 2013. Cyclic peptide-capped gold nanoparticles as drug delivery systems. Mol. Pharm., 10: 500-511.
    CrossRef  |  

  12. Shelke, G.M., V.K. Rao, R. Tiwari, B.S. Chhikara, K. Parang and A. Kumar, 2013. Bismuth triflate-catalyzed condensation of indoles with acetone. RSC Adv., 3: 22346-22352.
    CrossRef  |  

  13. Rao, V.K., R. Tiwari, B.S. Chhikara, A.N. Shirazi, K. Parang and A. Kumar, 2013. Copper triflate-mediated synthesis of 1,3,5-triarylpyrazoles in [bmim][PF6] ionic liquid and evaluation of their anticancer activities. RSC Adv., 3: 15396-15403.
    CrossRef  |  

  14. Rao, V.K., G. Shelke, R. Tiwari, K. Parang and A. Kumar, 2013. A simple and efficient synthesis of 2,3-diarynaphthofurans using sequential hydroarylation/heck oxyarylation. Org. Lett., 15: 2190-2193.

  15. Pericherla, K., A.N. Shirazi, V.K. Rao, R.K. Tiwari and N. Dasilva et al., 2013. Synthesis and antiproliferative activities of quebecol and its analogs. Bioorg. Med. Chem. Lett., 23: 5329-5331.
    CrossRef  |  

  16. Mandal, D., R.K. Tiwari, A.N. Shirazi, G. Ye, A. Banerjee, A. Yadav and K. Parang, 2013. Self-assembled surfactant cyclic peptide nanostructures as stabilizing agents. Soft Matter, 9: 9465-9475.
    CrossRef  |  

  17. Jha, R.R., J. Singh, R.K. Tiwari and A.K. Verma, 2013. Benzotriazol-1-yl-ethanol: An excellent bidentate ligand for the copper/palladium catalyzed C-N and C-C coupling reaction. Arkivoc, 2: 228-248.

  18. Chand, K., A.N. Shirazi, P. Yadav, R.K. Tiwari, M. Kumari, K. Parang and S.K. Sharma, 2013. Synthesis and antiproliferative and c-Src kinase inhibitory activities of cinnamoyl- and pyranochromen-2-one derivatives. Can. J. Chem., 91: 741-754.
    CrossRef  |  

  19. Cao, C., M.S. Rioult-Pedotti, P. Migani, C.J. Yu and R. Tiwari et al., 2013. Impairment of TrkB-PSD-95 signaling in Angelman syndrome. PLoS Biol., Vol. 11. 10.1371/journal.pbio.1001478.
    CrossRef  |  

  20. Verma, A.K., R.R. Jha, R. Chaudhary, R. Tiwari, K.S.K. Reddy and A. Danodia, 2012. Copper-catalyzed tandem synthesis of Indolo-, Pyrrolo[2,1-a]isoquinolines, naphthyridines and bisindolo/pyrrolo[2, 1-a]isoquinolines via hydroamination of orthohaloarylalkynes J. Org. Chem., 77: 8191-8205.

  21. Tiwari, R.K. and K. Parang, 2012. Conformationally constrained peptides as protein tyrosine kinase inhibitors. Curr. Pharm. Des., 18: 2852-2866.
    Direct Link  |  

  22. Shukla, S.P., R.K. Tiwari and A.K. Verma, 2012. Palladium-catalyzed Sonogashira-coupling conjoined C-H activation: a regioselective tandem strategy to access indolo- and pyrrolo[1,2-a]quinolines. J. Org. Chem., 77: 10382-10392.
    CrossRef  |  

  23. Shukla, S.P., R. Tiwari and A.K. Verma, 2012. Silver-catalyzed regioselective synthesis of acridines, quinolines and naphthalenes from 3-(2-alkynyl)aryl-β-ketoesters. Tetrahedron, 68: 9035-9044.
    CrossRef  |  

  24. Sharma, R.K., S. Singh, R. Tiwari, D. Mandal and C.E. Olsen et al., 2012. O-Aryl α,β-d-ribofuranosides: Synthesis and highly efficient biocatalytic separation of anomers and evaluation of their Src kinase inhibitory activity. Bioorg. Med. Chem., 20: 6821-6830.
    CrossRef  |  

  25. Rustagi, V., R. Tiwari and A.K. Verma, 2012. A regioselective access to diversely substituted fused benzimidazo[2,1-a]isoquinolines, naphthyridines, thienopyridines and quinoxalines in water. Eur. J. Org. Chem., 24: 4590-4602.

  26. Rao, V.K., B.S. Chhikara, R. Tiwari, A.N. Shirazi, K. Parang and A. Kumar, 2012. One-pot regioselective synthesis of tetrahydroindazolones and evaluation of their anticancer and Src Kinase inhibitory activities. Bioorg. Med. Chem. Lett., 22: 410-414.

  27. Rao, M.S., B.S. Chhikara, R. Tiwari, A.N. Shirazi, K. Parang and A. Kumar, 2012. Microwave-assisted and scandium triflate catalyzed synthesis of tetrahydrobenzo[a]xanthen-11-ones. Monatsh. Chem. Chem. Mon., 143: 263-268.
    CrossRef  |  

  28. Rao, M.S., B.S. Chhikara, R. Tiwari, A.N. Shirazi, K. Parang and A. Kumar, 2012. A greener synthesis of 2-aminochromenes in ionic liquid and evaluation of their antiproliferative activities. Chem. Biol. Interface, 2: 362-372.

  29. Rafinejad, A., A. Fallah-Tafti, R. Tiwari, A.N. Shirazi and D. Mandal et al., 2012. 4-Aryl-4H-naphthopyrans derivatives: One-pot synthesis, evaluation of Src kinase inhibitory and anti-proliferative activities. DARU J. Pharm. Sci., Vol. 20. 10.1186/2008-2231-20-100.
    CrossRef  |  

  30. Kumar, A., M. Muthyala, S. Choudhary, R.K. Tiwari and K. Parang, 2012. Ionic liquid as soluble support for synthesis of 1,2,3-thiadiazoles and 1,2,3-selenadiazoles. J. Org. Chem., 77: 9391-9396.
    CrossRef  |  

  31. Joshi, M., M. Patel, R. Tiwari and A.K. Verma, 2012. Base-mediated selective synthesis of diversely substituted N-heterocyclic enamines and enaminones by the hydroamination of alkynes. J. Org. Chem., 77: 5633-5645.
    CrossRef  |  

  32. Chhikara, B.S., R. Tiwari and K. Parang, 2012. N-Myristoylglutamic acid derivative of 3'-fluoro-3'-deoxythymidine as an organogel. Tetrahedron Lett., 53: 5335-5337.
    Direct Link  |  

  33. Aggarwal, T., S. Kumar, D.K. Dhaked, R.K. Tiwari, P.V. Bharatam and A.K. Verma, 2012. Site-selective electrophilic cyclization and subsequent ring-opening: A synthetic route to pyrrolo[1,2-a]quinolines and indolizines. J. Org. Chem., 77: 8562-8573.
    CrossRef  |  

  34. Aggarwal, T., R.R. Jha, R. Tiwari, S. Kumar, S.K.R. Kotla, S. Kumar and A.K. Verma, 2012. Palladium-catalyzed regioselective [3-2] annulation of internal alkynes and iodo-pyranoquinolines with concomitant ring opening. Org. Lett., 14: 5184-5187.
    CrossRef  |  

  35. Tiwari, R., Y. Ahmadibeni, C. Swepson, J. Pandhare, C. Dash, G.F. Doncel and K. Parang, 2011. Synthesis and anti-HIV activities of bis-(cycloSaligenyl) pronucleotides derivatives of 3′-fluoro-3′-deoxythymidine and 3′-azido-3′-deoxythymidine. Tetrahedron Lett., 52: 802-805.

  36. Sharma, D., R.K. Sharma, S. Bhatia, R. Tiwari and D. Mandal et al., 2011. Synthesis, src kinase inhibitory and anticancer activities of 1-substituted 3-(N-alkyl-N-phenylamino)propane-2-ols. Biochimie, 92: 1164-1172.

  37. Rao, V.K., B.S. Chhikara, A.N. Shirazi, R. Tiwari, K. Parang and A. Kumar, 2011. 3-Substitued indoles: One-pot synthesis and evaluation of anticancer and src kinase inhibitory activities. Bioorg. Med. Chem. Lett., 21: 3511-3514.
    CrossRef  |  

  38. Kumar, D., V.B. Reddy, A. Kumar, D. Mandal, R. Tiwari and K. Parang, 2011. Click chemistry inspired one-pot synthesis of 1,4-disubstituted 1,2,3-triazoles and their src kinase inhibitory activity. Bioorg. Med. Chem. Lett., 21: 449-452.
    CrossRef  |  

  39. Kumar, A., I. Ahmad, B.S. Chhikara, R. Tiwari, D. Mandal and K. Parang, 2011. Synthesis of 3-phenylpyrazolopyrimidine-1,2,3-triazole conjugates and evaluation of their Src kinase inhibitory and anticancer activities. Bioorg. Med. Chem. Lett., 21: 1342-1346.
    CrossRef  |  

  40. Kathuria, A., S. Jalal, R. Tiwari, A.N. Shirazi and S. Gupta et al., 2011. Substituted coumarin derivatives: Synthesis and evaluation of antiproliferative and Src kinase inhibitory activities. Chem. Biol. Interface, 1: 279-296.

  41. Fallah-Tafti, A., R. Tiwari, A.N. Shirazi, T. Akbarzadeh and D. Mandal et al., 2011. 4-Aryl-4H-chromene-3-carbonitrile derivatives: evaluation of Src kinase inhibitory and anticancer activities. Med. Chem., 7: 466-472.
    Direct Link  |  

  42. Fallah-Tafti, A., A. Foroumadi, R.K. Tiwari, A.N. Shirazi and D.G. Hangauer et al., 2011. Thiazolyl N-benzyl-substituted acetamide derivatives: Synthesis, src kinase inhibitory and anticancer activities. Eur. J. Med. Chem., 46: 4853-4858.
    CrossRef  |  

  43. Tiwari, R., A. Brown, S. Narramaneni, G. Sun and K. Parang, 2010. Synthesis and evaluation of conformationally constrained peptide analogues as the Src SH3 domain binding ligands. Biochimie, 92: 1153-1163.
    CrossRef  |  

  44. Tiwari, R. and K. Parang, 2009. Protein conjugates of SH3-domain ligands and ATP-competitive inhibitors as bivalent inhibitors of protein kinases. Chembiochem, 10: 2445-2448.
    CrossRef  |  

  45. Ahmadibeni, Y., R.K. Tiwari, G. Sun and K. Parang, 2009. Synthesis of nucleoside mono-, di- and triphosphoramidates from solid-phase cyclosaligenyl phosphitylating reagents. Org. Lett., 11: 2157-2160.
    CrossRef  |  

  46. Ye, G., R. Tiwari and K. Parang, 2008. Development of Src tyrosine kinase substrate binding site inhibitors. Curr. Opin. Invest. Drugs, 9: 605-613.
    Direct Link  |  

  47. Verma, A.K., P. Attri, V. Chopra, R.K. Tiwari and R. Chandra, 2008. Triethylammonium acetate (TEAA): A recyclable inexpensive ionic liquid promotes the chemoselective aza- and thia-Michael reactions. Monatsh. Chem. Chem. Monthly, 139: 1041-1047.
    CrossRef  |  

  48. Sharma, M., S.K. Rai, R.K. Tiwari, M. Tiwari and R. Chandra, 2008. Effects of nitric oxide modulators on cardiovascular risk factors in mild hyperhomocysteinaemic rat model. Basic Clin. Pharmacol. Toxicol., 103: 25-30.
    CrossRef  |  

  49. Verma, A.K., S. Bansal, J. Singh, R.K. Tiwari and V.K. Sankar et al., 2006. Synthesis and in vitro cytotoxicity of haloderivatives of noscapine. Bioorg. Med. Chem., 14: 6733-6736.
    CrossRef  |  

  50. Tiwari, R.K., D. Singh, J. Singh, V. Yadav and A.K. Pathak et al., 2006. Synthesis and antibacterial activity of substituted 1,2,3,4-tetrahydropyrazino [1,2-a] indoles. Bioorg. Med. Chem. Lett., 16: 413-416.
    Direct Link  |  

  51. Tiwari, R.K., D. Singh, J. Singh, A.K. Chhillar, R. Chandra and A.K. Verma, 2006. Synthesis, antibacterial activity and QSAR studies of 1,2-disubstituted-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolines. Eur. J. Med. Chem., 41: 40-49.
    CrossRef  |  

  52. Tiwari, R.K., A.K. Verma, A.K. Chhillar, D. Singh and J. Singh et al., 2006. Synthesis and antifungal activity of substituted-10-methyl-1,2,3,4-tetrahydropyrazino[1,2-a]indoles. Bioorg. Med. Chem., 14: 2747-2752.
    Direct Link  |  

  53. Tiwari, R.K., J. Singh, D. Singh, A.K. Verma and R. Chandra, 2005. Highly efficient one-pot synthesis of 1-substituted-1,2,3,4-tetrahydropyrazino[1,2-a]indoles. Tetrahedron, 61: 9513-9518.
    CrossRef  |