Dr. Darakhshan Jabeen Haleem
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Dr. Darakhshan Jabeen Haleem

Professor
University of Karachi, Pakistan

Highest Degree
Ph.D. in Neurochemistry from London University, U.K.

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Area of Interest:

Chemistry
100%
Neurochemistry
62%
Metabolism
90%
Biochemistry
75%
Pharmacology
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
0
Abstracts
0

Selected Publications

  1. Samad, N. and D. Haleem, 2017. Antioxidant effects of rice bran oil mitigate repeated haloperidol-induced tardive dyskinesia in male rats. Metab. Brain Dis., 32: 1099-1107.
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  2. Ikram, H.. B. Mirza and D.J. Haleem, 2017. Neurochemical and behavioral effects of green tea Camellia sinensis) as observed in animals exposed to restraint stress. Pak. J. Pharm. Sci., 30: 487-492.
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  3. Ikram, H. and D. Haleem, 2017. Repeated treatment with reserpine as a progressive animal model of depression. Pak. J. Pharm. Sci., 30: 897-902.
    PubMed  |  Direct Link  |  
  4. Haleem, D.J., S Sheikh, A. Fawad and M.A. Haleem, 2017. Fasting leptin and glucose in normal weight, over weight and obese men and women diabetes patients with and without clinical depression. Metab. Brain Dis., 32: 757-764.
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  5. Haleem, D.J., 2017. Improving therapeutics in anorexia nervosa with tryptophan. Life Sci., 78: 87-93.
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  6. Haleem, D.J. and S. Nawaz, 2017. Inhibition of reinforcing, hyperalgesic, and motor effects of morphine by buspirone in rats. J. Pain., 18: 19-28.
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  7. Aftab, M.F., S.K. Afridi, U.R. Mughal, A. Karim and D.J. Haleem et al., 2017. New isatin derivative inhibits neurodegeneration by restoring insulin signaling in brain. J. Chem. Neuroanat., 81: 1-9.
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  8. Samad, N., M.A. Haleem and D.J. Haleem, 2016. Report: Protective effects of rice bran oil in haloperidol-induced tardive dyskinesia and serotonergic responses in rats. Pak J Pharm Sci. 29: 1467-1471.
    PubMed  |  Direct Link  |  
  9. Samad, N., F. Yasmin and D.J. Haleem, 2016. Co-treatment with imipramine averted haloperidol-instigated tardive dyskinesia: Association with serotonin in brain regions. Pak. J. Pharm. Sci., 29: 2273-2279.
    PubMed  |  Direct Link  |  
  10. Malik, T., S. Hasan, S. Pervez, T. Fatima and D.J. Haleem, 2016. Nigella sativa oil reduces extrapyramidal symptoms (eps)-like behavior in haloperidol-treated rats. Neurochem Res., 41: 3386-3398.
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  11. Inam, Q.U., H. Ikram, E. Shireen and D.J. Haleem, 2016. Effects of sugar rich diet on brain serotonin, hyperphagia and anxiety in animal model of both genders. Pak. J. Pharm. Sci., 29: 757-763.
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  12. Haleem, D.J., 2016. Drug targets for obesity and depression: From serotonin to leptin. Curr. Drug. Targets. 17: 1282-1291.
    PubMed  |  Direct Link  |  
  13. Haider, S., S. Sadir, F. Naqvi, Z. Batool and S. Tabassum et a., 2016. Magnesium treatment palliates noise-induced behavioral deficits by normalizing DAergic and 5-HTergic metabolism in adult male rats. Metab. Brain Dis., 31: 815-825.
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  14. Farhan, M. and D.J. Haleem, 2016. Attenuation of unpredictable Chronic Mild Stress induced deficits in rats by Apomorphine. J. Pak. Med. Assoc., 66: 1541-1546.
  15. Farhan, M. and D.J. Haleem, 2016. Anxiolytic profile of fluoxetine as monitored following repeated administration in animal rat model of chronic mild stress. Saudi Pharm. J., 24: 571-578.
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  16. Cheema, M.A.R., S. Nawaz, S. Gul, T. Salman, S. Naqvi, A. Dar and D.J. Haleem, 2016. Neurochemical and behavioral effects of Nigella sativa and Olea europaea oil in rats. Nutr. Neurosci., 21: 1-10.
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  17. Yasmin, F., Z. Haque, H. Ikram and D.J. Haleem, 2015. Immobilization-induced increases of systolic blood pressure and dysregulation of electrolyte balance in ethanol-treated rats. Pak J Pharm Sci., 28: 1365-1372.
    PubMed  |  Direct Link  |  
  18. Shireen, E., W. Bint-E-Ali, S. Shafaq, A. Majeed, R. Fatima, M. Masroor and D.J. Haleem, 2015. Reversal of immobilization stress-induced anorexia and endogenous leptin levels by Rauwolfia serpentine in rats: relationship with adaptation to stress. Int. J. Dev. Neurosci., .
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  19. Sheikh, S.A., H. Ikram and D.J. Haleem, 2015. Behavioral deficits in rats following acute administration of glimepiride: Relationship with brain serotonin and dopamine. Pak J Pharm Sci., 28: 1181-1186.
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  20. Kanwal, S., H. Ikram, M. Farhan and D.J. Haleem, 2015. Apomorphine induced conditioned place preference and sensitization is greater in rats exposed to unpredictable chronic mild stress. Pak J Pharm Sci. 28: 1927-1932.
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  21. Jabeen, B.J., S. Tabassum, S. Haider, T. Perveen, A. Nawaz, and D.J. Haleem, 2015. Nootropic and anti-stress effects of rice bran oil in male rats. J. Food Sci. Technol., 52: 4544-4550.
    CrossRef  |  Direct Link  |  
  22. Haleem, D.J., Z. Haque, Q.U. Inam, H. Ikram and M.A. Haleem, 2015. Behavioral, hormonal and central serotonin modulating effects of injected leptin. Peptides, 74: 1-8.
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  23. Haleem, D.J., Q.U. Inam, S. Haider, T. Perveen and M.A. Haleem, 2015. Serum leptin and cortisol, related to acutely perceived academic examination stress and performance in female university students. Appl. Psychophysiol. Biofeedback, 40: 305-312.
  24. Haleem, D.J., Q. Inam and M.A. Haleem, 2015. Effects of clinically relevant doses of methyphenidate on spatial memory, behavioral sensitization and open field habituation: A time related study. Behav. Brain Res., 281: 208-214.
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  25. Haleem, D.J. and M. Farhan, 2015. Inhibition of apomorphine-induced behavioral sensitization in rats pretreated with fluoxetine. Behav. Pharmacol., 26: 159-166.
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  26. Haleem, D., 2015. 5-HT1A receptor-dependent control of nigrostriatal dopamine neurotransmission in the pharmacotherapy of Parkinson's disease and schizophrenia. Behav Pharmacol. 26: 45-58.
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  27. Shireen, E., S. Pervez, M. Masroor, W.B. Ali and Q. Rais et al., 2014. Reversal of haloperidol induced motor deficits in rats exposed to repeated immobilization stress. Pak. J. Pharm. Sci. 27: 1459-1466.
    PubMed  |  Direct Link  |  
  28. Samad, N. and D.J. Haleem, 2014. Haloperidol-induced extra pyramidal symptoms attenuated by imipramine in rats. Pak J Pharm Sci. 27: 1497-1507.
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  29. Ikram, H., F. Mushtaq and D.J. Haleem, 2014. Dose-dependent effects of tryptophan on learning and memory. Pak. J. Pharm. Sci., 27: 1131-1135.
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  30. Haque, Z., A. Javed, A. Mehmood, A. Haque and D.J. Haleem, 2014. Gender and stress perception based differences in BMI, hormonal response and appetite in adult Pakistani population. J. Coll. Physicians Surg. Pak., 24: 705-709.
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  31. Haleemm, D.J., Z. Haque, H. Ikram and M.A. Haleem, 2014. Leptin and other hormonal responses to different stressors: relationship with stress-induced behavioral deficits. Pak. Vet. J., 34: 504-507.
  32. Haleem, D.J., H. Ikram and M.A. Haleem, 2014. Inhibition of apomorphine-induced conditioned place preference in rats co-injected with buspirone: relationship with serotonin and dopamine in the striatum. Brain Res., 1586: 73-82.
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  33. Haleem, D.J., 2014. Investigations into the involvement of leptin in responses to stress. Behav. Pharmacol., 25: 384-397.
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  34. Farhan, M., H. Ikram, S. Kanwal and D.J. Haleem, 2014. Unpredictable chronic mild stress induced behavioral deficits: a comparative study in male and female rats. Pak. J. Pharm. Sci., 27: 879-884.
    PubMed  |  Direct Link  |  
  35. Shireen, E., S. Naeem, Q.U. Inam and D.J. Haleem, 2013. Oral administration of haloperidol at clinically recommended doses elicits smaller parkinsonian effects but more tardive dyskinesia in rats. Pak. J. Pharm. Sci., 26: 271-276.
    PubMed  |  Direct Link  |  
  36. Saleem, D.M., S. Haider, D.J. Haleem, M. Shafaque and M.M. Khan, 2013. Altered brain monoamines metabolism in thioacetamide induced hepatic encephalopathy in rats. Int. J. Toxicol. Pharmaco. Res., 5: 96-101.
  37. Perveen, T., S. Haider, W. Mumtaz, F. Razi, S. Tabassum and D.J. Haleem, 2013. Attenuation of stress-induced behavioral deficits by lithium administration via serotonin metabolism. Pharmacol. Rep., 65: 336-342.
    PubMed  |  Direct Link  |  
  38. Perveen, T., F. Razi, S. Haider, H. Qayyum and D.J. Haleem, 2013. Antidepressant and anxiolytic effects of cod liver oil in rats. Pak. Vet. J., 33: 57-59.
  39. Mirza, B., H. Ikram, S. Bilgrami, D.J. Haleem and M.A. Haleem, 2013. Neurochemical and behavioral effects of green tea (Camellia sinensis): A model study. Pak. J. Pharm. Sci., 26: 511-516.
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  40. Haque, Z., N. Akbar, F. Yasmin, M.A. Haleem and D.J. Haleem, 2013. Inhibition of immobilization stress-induced anorexia, behavioral deficits and plasma corticosterone secretion by injected leptin in rats. Stress: Int. J. Biol. Stress, 16: 353-362.
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  41. Haleem, D.J., H. Ikram, S. Haider, T. Parveen and M.A. Haleem, 2013. Enhancement and inhibition of apomorphine-induced sensitization in rats exposed to immobilization stress: relationship with adaptation to stress. Pharmacol. Biochem. Behav., 112: 22-28.
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  42. Haleem, D.J., 2013. Extending therapeutic use of psychostimulants: Focus on serotonin-1A receptor. Prog. Neuropsychopharmacol. Biol. Psychiatry., 46: 170-180.
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  43. Haleem, D.J. and H. Ikram, 2013. Immobilization-induced behavioral deficits are attenuated but coping with repeated stress impaired in apomorphine injected rats. Curr. Psychopharmacol., 2: 254-259.
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  44. Haider, S., S. Saleem, S. Tabassum, S. Khaliq and S. Shamimet al., 2013. Alteration in plasma corticosterone levels following long term oral administration of lead produces depression like symptoms in rats. Metab. Brain Dis., 28: 85-92.
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  45. Haider, S., S. Ahmed, S. Tabassum, M. Ikram and D.J. Haleem, 2013. Streptozotocin-induced insulin deficiency leads to development of behavioral deficits in rats. Acta Neurol. Belg., 113: 35-41.
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  46. Farhan, M., H. Ikram and D.J. Haleem, 2013. Chronic mild stress (CMS)-induced behavioral deficits were attenuated by fluoxetine. Pak. J. Biochem. Mol. Biol., 46: 65-69.
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  47. Tafheem, M. and D.J. Haleem, 2012. Injected haloperidol-lnduced motor deficits are potentiated in rats drinking green tea as a sole source of water: Relationship with dopamine metabolism in the caudate. J. Food Drug Anal., 20: 822-833.
    Direct Link  |  
  48. Samad, N. and D.J. Haleem, 2012. Effectiveness of somatodendritic and/or postsynaptic 5-HT-1A receptors following exposure to single restraint stress. Pak. J. Biochem. Mol. Biol., 45: 166-171.
  49. Perveen, T., F. Razi, S. Haider, H. Qayyum and D.J. Haleem, 2012. Antidepressant and anxiolytic effects of cod liver oil in rats. Pak. Vet. J. Pak. Vet J., 33: 57-59.
  50. Naqvi, F., S.. Haider, Z. Batool, T. Perveen and D.J. Haleem, 2012. Sub-chronic exposure to noise affects locomotor activity and produces anxiogenic and depressive like behavior in rats. Pharmacol. Rep., 64: 64-69.
    PubMed  |  Direct Link  |  
  51. Moin, S., S. Haider, S. Khaliq, S. Tabassum and D.J. Haleem, 2012. Behavioral and neurochemical studies in stressed and unstressed rats fed on protein, carbohydrate and fat rich diet. Pak. Vet. J., 32: 260-264.
  52. Khaliq, S., S. Haider, S. Tabassum, S. Nawaz, W. Ahmed, D.J. Haleem and T. Parveen, 2012. Behavioral effects following administration of olive oil in rats. Asian J. Pharm. Biol. Res., 2: 59-64.
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  53. Khaliq, S., S. Haider, S. Saleem, Z. Memon and J.D. Haleem, 2012. Influence of serotonergic 5-HT2C receptor antagonist mesulergine in the reversal of memory deficits induced by mCPP. J. Coll. Physicians Surg. Pak., 22: 75-79.
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  54. Khaliq, S., S.Haider, F. Naqvi, T. Perveen, S. Saleem and D.J. Haleem, 2012. Altered brain serotonergic neurotransmission following caffeine withdrawal produces behavioral deficits in rats. Pak. J. Pharm. Sci., 25: 21-25.
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  55. Ikram, H., A..M. Choudhry and D.J. Haleem, 2012. Regional neurochemical profile following development of apomorphine-induced reinforcement. Pak. J. Pharm. Sci., 25: 513-519.
    PubMed  |  Direct Link  |  
  56. Haque, Z., F. Yasmeen and D.J. Haleem, 2012. A G15719C leptin gene polymorphism is associated with lesser perception of stress and other physiological reactions to stress in adult working Pakistani women. Int. J. Collaborative Res. Int. Med. Pub. Health, 4: 296-307.
  57. Haleem, D.J., 2012. Serotonin neurotransmission in anorexia nervosa. Behav. Pharmacol., 23: 478-495.
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  58. Haider, S., Z. Batool and D.J. Haleem, 2012. Nootropic and hypophagic effects following long term intake of almonds (Prunus amygdalus) in rats. Nutr. Hosp.. 27: 2109-2115.
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  59. Haider, S., F. Naqvi, Z. Batool, S. Tabassun, T. Perveen, S. Saleem and D.J. Haleem, 2012. Decreased Hippocampal 5-HT and DA Levels Following Sub-Chronic Exposure to Noise Stress: Impairment in both Spatial and Recognition Memory in male rats. Sci. Pharm., 80: 1001-1011.
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  60. Haider, S., S. Khaliq, S. Tabassum and D.J. Haleem, 2012. Role of somatodendritic and postsynaptic 5-ht1a receptors on learning and memory functions in rats. Neurochemical Research, 37: 2161-2166.
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  61. Akhtar, S., M. Arif, N. Mushtaq, Z.S. Saify, A. Ahmed, D.J. Haleem and A. Akram, 2012. Behavioral and neurochemical profile of some novel phenacyl based isonipecotamide derivatives. Pak. J. Pharm. Sci., 25: 705-713.
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  62. Shireen, E. and D.J. Haleem, 2011. Reversal of haloperidol-induced motor deficits by mianserin and mesulergine in rats. Pak. J. Pharm. Sci., 24: 7-12.
    PubMed  |  Direct Link  |  
  63. Ikram, H., S. Ahmad and D.J. Haleem, 2011. Effects of apomorphine on locomotive activity and monoamine metabolism: A dose related study. Pak J Pharm Sci. 24: 315-321.
    PubMed  |  Direct Link  |  
  64. Ikram, H. and D..J. Haleem, 2011. Attenuation of apomorphine-induced sensitization by buspirone. Pharmacol. Biochem. Behav., 99: 444-450.
    CrossRef  |  Direct Link  |  
  65. Haleem, D.J., 2011. Raphe-hippocampal serotonin neurotransmission in the sex related differences of adaptation to stress: Focus on serotonin-1A receptor. Curr. Neuropharmacol., 9: 512-521.
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  66. Haleem, D.J., 2011. Behavioral deficits and exaggerated feedback control over raphe-hippocampal serotonin neurotransmission in restrained rats. Pharmacol. Rep., 63: 888-897.
    PubMed  |  Direct Link  |  
  67. Haider, S., Z. Batool, S. Tabassum, T. Perveen and S. Saleem et al., 2011. Effects of walnuts (Juglans regia) on learning and memory functions. Plant Foods Hum. Nutr., 66: 335-340.
    CrossRef  |  Direct Link  |  
  68. Batool, F., A. Kamal, M. Sattar, A.H. Shah, S.D. Ahmed, Z.S. Saify and D.J. Haleem, 2011. Evaluation of antidepressant-like effects of aqueous extract of sea buckthorn (hippophae rhamnoides L. ssp. turkestanica) fruitsin experimental models of depression. Pak. J. Botany, 43: 1595-1599.
  69. Alam, N., D.J. Haleem, R.S. Haider and S.P. Ahmed, 2011. Hypophagic and hypolocomotive effects of metachloro phenyl piperazine in rats treated with theophylline and caffeine. Pak. J. Pharm. Sci., 24: 251-254.
  70. Ikram, H., and D.J. Haleem, 2010. Haloperidol-induced tardive dyskinesia: Role of 5-HT 2C receptors. Pak. J. Sci. Ind. Res., 53: 136-145.
  71. Batool, F., M.A. Haleem and D.J. Haleem 2010. Acute Administration of Clozapine and Risperidone Altered Dopamine Metabolism More in Rat Caudate than in Nucleus Accumbens: A Dose-Response Relationship Sci. Pharma 78: 259-274.
    CrossRef  |  
  72. Batool, F., A.H. Shah, S.D. Ahmed, Z.S. Saify and D.J. Haleem, 2010. Protective effects of aqueous fruit extract from sea Buckthorn (Hippophae rhamnoides L. spp. Turkestanica) on haloperidol-induced orofacial dyskinesia and neuronal alterations in the striatum. Med. Sci. Monitor, 16: BR285-BR292.
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  73. Batool, F., A. Hasnat, M.A. Haleem and D.J. Haleem, 2010. Dose-related effects of clozapine and risperidone on the pattern of brain regional serotonin and dopamine metabolism and on tests related to extrapyramidal functions in rats. Acta Pharm., 60: 129-140.
    PubMed  |  
  74. Samad, N. and D.J. Haleem, 2009. Behavioral and neurochemical profile of m-CPP following exposure to single restraint stress in rat. Acta Neurol. Belg., 109: 24-31.
    PubMed  |  Direct Link  |  
  75. Perveen, T., S. Haider, S. Kanwal and D.J. Haleem, 2009. Repeated administration of Nigella sativa decreases 5-HT turnover and produces anxiolytic effects in rats. Pak. J. Pharm. Sci., 22: 139-144.
    PubMed  |  Direct Link  |  
  76. Inam, Q.U., M.A. Haleem and D.J. Haleem, 2009. Attenuation of somatodendritic responses to 8-hydroxy-2-di-npropylamino tetralin following long-term dietary sugar consumption in rats. J. Coll. Physicians Surg. Pak., 19: 401-405.
    Direct Link  |  
  77. Haleem, D.J., 2009. Exaggerated feedback control decreases brain serotonin concentration and elicits hyperactivity in a rat model of diet-restriction-induced anorexia nervosa. Appetite, 52: 44-50.
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  78. Batool, F., S. Ahmed and D.J. Haleem 2009. Dietary supplementations of amino acids: Evidence for enhanced serotonergic functions following haloperidol withdrawal in rat medial prefrontal cortex. J. Coll. Physicians Surg. Pak., 19: 139-145.
    Direct Link  |  
  79. Batool, F., A.H. Shah, S.D. Ahmed, Z.S. Saify and D.J. Haleem, 2009. Possible anxiolytic profile of aqueous fruit extracts of a medicinal plant sea buckthorn (Hippophae rhamnoides L. spp. Turkestanica) in experimental models. Pak. J. Bot., 41: 2791-2800.
    Direct Link  |  
  80. Batool, F., A.H. Shah, S.D. Ahmed and D.J. Haleem, 2009. Oral supplementation of Sea Buckthorn (Hippophae rhamnoides L. spp. Turkestanica) fruit extract modifies haloperidol induced behavioral deficits and increases brain serotonin metabolism. J. Food Drug Anal., 17: 257-263.
    Direct Link  |  
  81. Samad, N., M.A. Haleem and D.J. Haleem, 2008. Behavioral effects of 1-(m-chlorophenyl)piperazine (m-CPP) in a rat model of tardive dyskinesia. Pak. J. Pharm. Sci., 21: 262-268.
    PubMed  |  
  82. Saleem, D.M., S. Haider, M.M. Khan, T. Shamsi and D.J. Haleem, 2008. Role of tryptophan in the pathogenesis of hepatic encephalopathy. J. Pak. Med. Assoc., 58: 68-70.
    PubMed  |  Direct Link  |  
  83. Naz, H., N. Baig, S. Haider and D.J. Haleem, 2008. Subchronic treatment with mercuric chloride suppresses immune response, elicits behavioral deficits and increases brain serotonin and dopamine metabolism in rats. Pak. J. Pharm. Sci., 21: 7-11.
    PubMed  |  
  84. Khan, A., and D.J. Haleem, 2008. Responsiveness of 5-HT2C receptors in repeatedly diazepam-injected rats: a behavioral and neurochemical study. Pharmacol. Rep., 60: 716-724.
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  85. Khan, A., M.A. Haleem and D.J. Haleem, 2008. Dopamine and serotonin metabolism in the dorsal and ventral striatum of haloperidol-induced tardive dyskinesia model in rats. J. Chem. Soc. Pak., 30: 410-416.
  86. Khaliq, S., B. Irfan, S. Haider, D.J. Haleem, 2008. M-CPP induced hypolocomotion does not interfere in the assessment of memory functions in rats. Pakistan J. Pharm. Sci., 21: 139-143.
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  87. Jabeen, B. and D.J. Haleem, 2008. Desensitization of pre and post synaptic 5-HT-1A receptor responses following long term consumption of sugar rich diet: Implications for sugar-induced obesity. Pak. J. Pharm. Sci., 21: 327-332.
    PubMed  |  
  88. Inam, Q.U.A., M. A. Haleem and D.J. Haleem, 2008. Neurochemical profile of 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) induced hyperphagia in sugar rich diet treate rats. J Chem. Soc. Pak., 30: 431-435.
  89. Inam, Q.U.A., B. Jabeen, M.A. Haleem and D.J. Haleem, 2008. Long-term consumption of sugar-rich diet decreases the effectiveness of somatodendritic serotonin-1A receptors. Nutr. Neurosci., 11: 277-282.
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  90. Haider, S., N. Naz, S. Khaliq, T. Perveen and D.J. Haleem, 2008. Repeated administration of fresh garlic increases memory retention in rats. J. Med. Food, 11: 675-679.
    PubMed  |  
  91. Batool, F. and D.J. Haleem, 2008. Serotonin(1A) receptor agonism in the expression of behavioral dopaminergic supersensitivity in subchronic haloperidol treated rats. Pak. J. Pharm. Sci., 21: 411-420.
    PubMed  |  
  92. Yasmeen, F., D.J. Haleem and M.A. Haleem, 2007. Effects of repeated restraint stress on serum electrolytes in ethanol treated and water treated rats. Pak. J. Pharm. Sci., 20: 51-55.
  93. Samad, N., F. Batool and D.J. Haleem, 2007. Neurochemical and behavioral effects of 8-OH-DPAT following exposure to restraint stress in rats. Pharmacol. Rep., 59: 173-180.
    Direct Link  |  
  94. Samad, N., A. Khan, T. Perveen, S. Haider, M.A. Haleem and D.J. Haleem, 2007. Increase in the effectiveness of somatodendritic 5-HT-1A receptors in a rat model of Tardive dyskinesia. Acta Neurobiol. Exp., 67: 389-397.
    PubMed  |  
  95. Samad, N. and D.J. Haleem, 2007. Serotonin-1A receptor responsiveness in stress and following adaptation to stress. Pak. J. Pharm. Sci., 20: 115-119.
    PubMed  |  
  96. Khan, A. and D.J. Haleem, 2007. Tolerance in the anxiolytic profile following repeated administration of diazepam but not buspirone is associated with a decrease in the responsiveness of postsynaptic 5-HT-1A receptors. Acta Biol. Hung., 58: 345-357.
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  97. Khaliq, S., S. Haider and D.J. Haleem, 2007. Comparative effects of single dose and repeated oral tryptophan administration on indole amine synthesis and memory functions in rats. Pak. J. Pharm. Sci., 20: 71-76.
    PubMed  |  
  98. Jabeen, B., M. Badaruddin, R. Ali and D.J. Haleem, 2007. Attenuation of restraint-induced behavioral deficits and serotonergic responses by stabilized rice bran in rats. Nutr. Neurosci., 10: 11-16.
    PubMed  |  
  99. Ikram, H., N. Samad and D.J. Haleem, 2007. Neurochemical and behavioral effects of m-CPP in a rat model of tardive dyskinesia. Pak. J. Pharm. Sci., 20: 188-195.
    PubMed  |  
  100. Haleem, D.J., N. Samad, T. Perveen, S. Haider and M.A. Haleem, 2007. Role of serotonin-1A receptors in restraint-induced behavioral deficits and adaptation to repeated restraint stress in rats. Int. J. Neurosci., 117: 243-257.
    Direct Link  |  
  101. Haleem, D.J., N. Samad and M.A. Haleem, 2007. Reversal of haloperidol-induced tardive vacuous chewing movements and supersensitive serotonergic response by buspirone in rats. Pharmacol. Biochem. Behav., 87: 115-121.
    Direct Link  |  
  102. Haleem, D.J., N. Samad and M.A. Haleem, 2007. Reversal of haloperidol-induced extrapyramidal symptoms by buspirone: A time related study. Behav. Pharmacol., 18: 147-153.
  103. Haider, S., S. Khaliq and D.J. Haleem, 2007. Enhanced serotonergic neurotransmission in the hippocampus following tryptophan administration improves learning acquisition and memory consolidation in rats. Pharmacol. Rep., 59: 53-57.
    PubMed  |  
  104. Farooq, R., D.J. Haleem and M.A. Haleem, 2007. Dose related effects of buspirone on serum electrolyte balance, plasma osmolality and Systolic Blood Pressure (SBP) in rats. Pak. J. Pharma. Sci., 20: 295-299.
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  105. Ysmeen, F., D.J. Haleem and M.A. Haleem, 2006. Intraerythrocyte and serum electrolytes in diabetic patient with hypertension. JCPSP., 16: 445-449.
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  106. Samad, N., T. Perveen, S. Haider, M.A. Haleem and D.J. Haleem, 2006. Inhibition of restraint-induced neuroendocrine and serotonergic responses by buspirone in rats. Pharmacol. Rep., 58: 636-642.
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  107. Samad, N., T. Parveen, S. Haider and D.J. Haleem, 2006. Attenuation of stress-induced behavioral deficits by Azadirechta indica (Neem) role of serotonin. Pak. J. Bot., 38: 131-138.
  108. Samad, N., M.A. Haleem and D.J. Haleem, 2006. Neurochemical profile of 1-(m-chlorophenyl)piperazine (m-CPP) in the striatum of a rat model of tardive dyskinesia. J. Chem. Soc. Pak. 28: 605-610.
  109. Perveen, T., R. Rafiq, S. Haider and D.J. Haleem, 2006. Increased serotonergic functions following administration of 1-(1-naphthyl) piperzine in propranolo injected rats. Pak. J. Pharma. Sci., 19: 190-194.
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  110. Khan, A.,and D.J. Haleem, 2006. 5-HT-1A receptor responsiveness following subchronic administration of buspirone. J. Pharm. Sci 19: 333-337.
  111. Khaliq, S., S. Haider, S.P. Ahmed, T. Perveen and D.J. Haleem, 2006. Relationship of brain tryptophan and serotonin in improving cognitive performance in rats. Pak. J. Pharm. Sci., 19: 11-15.
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  112. Inam, Q.U., M.A. Haleem and D.J Haleem, 2006. Effects of long term consumption of sugar as part of meal on serotonin 1-a receptor dependent responses. Pak. J. Pharm. Sci., 19: 94-98.
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  113. Haleem, D.J., 2006. Review article: Serotonergic modulation of dopamine neurotransmission: A mechanism for enhancing therapeutics in schizophrenia. JCPSP., 16: 556-562.
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  114. Haider, S., S. Khaliq, S.P. Ahmed and D.J. Haleem, 2006. Long-term tryptophan administration enhances cognitive performance and increases 5HT metabolism in the hippocampus of female rats. Amino Acids., 31: 421-425.
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  115. Haider, S., M. Roohi, S. Khaliq, T. Perveen and D.J. Haleem, 2006. Oral administration of Phytolacca Baccis extract increases brain serotonin metabolism and decreases food intake in rats. Pak. J. Bot., 38: 745-750.
  116. Shireen, E. and D.J. Haleem, 2005. Motor effects of buspirone: Relationship with dopamine and serotonin in the striatum. JCPSP., 15: 753-756.
  117. Samad, N., T. Parveen, S. Haider and D.J. Haleem, 2005. Attenuation of restraint induced behavioral deficits by buspirone and propranolol in rats. J. Coll. Physicians Surg. Pak., 15: 795-798.
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  118. Haleem, D.J., A. Hasnat, E. Shireen, A. Khan and M.A. Haleem, 2005. Dopamine and serotonin neurotransmission in the reinforcing effects of alcohol and apomorphine. J. Coll. Physicians Surg. Pak., 15: 458-462.
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  119. Haider, S., S. Shameem, S.P. Ahmed, T. Perveen and D.J. Haleem, 2005. Repeated administration of lead decreases brain 5-HT metabolism and produces memory deficits in rats. Cell. Mol. Biol. Lett., 10: 669-676.
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  120. Ali, O., D.J. Haleem, Z.S. Saify, N. Kamil, R. Obaid and S.W. Ahmed, 2005. Effects of tryptophan and valine administration on behavioral pharmacology of haloperidol. Pak. J. Pharm. Sci., 18: 23-28.
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  121. Akhtar, S., Z.S. Saify, M. Arif, N. Mushtaq and D.J. Haleem, 2005. Neurochemical estimations of some new quaternary phenacyl-bromopiperidinium compounds. Pak. J. Pharm. Sci., 18: 52-54.
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  122. Haleem, D.J., E. Shireen and M.A. Haleem, 2004. Somatodendritic and Postsynaptic Serotonin-1A receptors in the attenuation of Haloperidol-induced Catalepsy. Neuropsychopharmacol. Biol. Psychiat, 28: 1323-1329.
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  123. Haider, S., S. Saleem, S. Shameem, S.P. Ahmed, T. Parveen and D.J. Haleem, 2004. Is anorexia in thioacetamide-induced cirrhosis related to an altered brain serotonin concentration? Pol. J. Pharmacol., 56: 73-78.
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  124. Hasnat, A., S. Haider,T. Perveen, I.M. Kidwai and D.J. Haleem, 2003. Decrease of ethanol intake following repeated injection of serotonin-1A agonist in rats: relationship with receptor responsiveness. J. Coll. Physicians Surg. Pak., 13: 305-308.
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  125. Haleem, D.J. and N.H. Khan, 2003. Enhancement of serotonin-1A receptor dependent responses following withdrawal of haloperidol in rats. Prog. Neuropsychopharmacol. Biol. Psychiat., 27: 645-651.
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  126. Haleem, D.J., Z.S. Saify, S. Siddiqui, F. Batool and M.A. Haleem, 2002. Pre and post synaptic responses to 1-(1-naphthylpiperazine) following adaptation to stress in rats. Prog. Neuropsychopharmacol. Biol. Psychiat., 26: 149-156.
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  127. Haleem, D.J., H. Naz, T. Parveen, S. Haider, S.P. Ahmed, N.H. Khan and M.A. Haleem, 2002. Serotonin and serotonin 1-A receptors in the failure of ethanol-treated rats to adapt to a repeated stress schedule. J. Stud. Alcohol., 63: 389-396.
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  128. Haleem, D.J., F. Batool, N.H. Khan, N. Kamil, O. Ali, Z.S. Saify and M.A. Haleem, 2002. Differences in the effects of haloperidol and clozapine on brain serotonin and dopamine metabolism and on tests related to extrapyramidal functions in rats. Med. Sci. Monitor, 8: BR354-BR361.
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  129. Haleem, D.J., F. Batool and N. Kamil, 2002. Dopamine/Serotonin metabolite ratio and extrapyramidal effects of clozapine in rats. JCPSP, 10: 588-592.
  130. Siddiqui, F.B.S. and D.J. Haleem, 2000. Neurochemical and behavioral profiles of 1-(1-naphthyl) piperazine in rats. JCPSP., 11: 50-56.
  131. Haleem, D.J., S. Haider, T. Perveen, Q. Inam, I.M. Kidwai and M.A. Haleem, 2000. Hyperphagia and decreases of brain serotonin in rats fed on a sugar rich diet for three weeks. Nutritional Neurosci. (USA), 3: 399-405.
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  132. Haider, S. and D.J. Haleem, 2000. Decreases of brain serotonin following food restriction schedule of 4 week in male and female rats. Medical Sci. Monitor, 6: 1061-1067.
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  133. Haleem, D.J., 1999. Serotonergic mechanism of antidepressant action and adaptation to stress. J. Coll. Physician Surgeon Pak., 9: 139-146.
  134. Haleem, D.J., 1999. Attenuation of 8-OH-DPAT-induced decreases in 5-HT synthesis in brain regions of rats adapted to a repeated stress schedule. Stress (USA), 3: 123-129.
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  135. Haider, S., N. Akhtar, I.M. Kidwai and D.J. Haleem, 1999. Enhancement of brain serotonin by long term oral administration of tryptophan produces no effect on food intake. JCPSP., 9: 503-506.
  136. Batool, F. and D.J. Haleem, 1999. Serotonin and Anxiety: A review of current research and clinical implications. JCPSP., 9: 384-393.
  137. Haleem, D.J., B. Jabeen and T. Parven, 1998. Inhibition of restraint-induced anorexia by injected tryptophan. Life Sci., .
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  138. Haider, S., A. Yasmeen, T. Parveen and D.J. Haleem, 1997. Long term tea intake attenuates brain monoamine metabolism in rats. J. Coll. Phys. Surgeons Pak., 7: 163-166.
  139. Tabassum, M., D.J. Haleem, M. Mumtaz and M.A. Haleem, 1996. Stress and hypertension: Role of serum, red cell and tissue electrolytes. Life Sci., 58: 1587-1590.
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  140. Haleem, D.J., 1996. Serotonin appetite and anorexia nervosa. JCPSP., 6: 167-172.
  141. Haleem, D.J., 1996. Adaptation to repeated restraint stress in rats: Failure of ethanol treated rats to adapt in the stress schedule. Alcohol. Alcoholism (Oxford), 31: 471-477.
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  142. Haleem, D.J. and S. Haider, 1996. Food restriction decreases serotonin and its synthesis rate in the hypothalamus. NeuroReport (England), 7: 1153-1156.
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  143. Haleem, D.J. and F. Batool, 1996. Regionally specific effects of diazepam on brain serotonin metabolism: sustained effects following repeated administration. Life Sci. USA., 59: PL239-PL246.
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  144. Haleem, D.J. A. Yasmeen, M.A. Haleem and A. Zafar, 1995. Withdrawal from repeated administration of caffeine attenuates brain serotonin but not tryptophan in rat brain: Implications for caffeine-induced depression. Life Sci., 57: PL285-PL292.
  145. Haleem, D.J., A.Yasmeen, T. Parveen and A. Zafar, 1994. Enhancement of hepatic tryptophan pyrrolase activity and decreases of open field locomotion following single and repeated administration of high doses of caffeine in rats. Life Sci., 54: PL297-PL304.
  146. Haleem, D.J., A. Zafar, S. Azam and A. Yasmeen, 1994. Tolerance to diacetyl morphine antinociception: Effects on brain serotonin. Neuroreport, 5: 781-784.
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  147. Haleem, D.J., 1994. Decreases of plasma tryptophan concentrations following restricted feeding do not decrease serotonin and its metabolite in rat brain. Nahrung, 38: 606-611.
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  148. Haleem, D.J. and T. Parveen, 1994. Brain regional serotonin synthesis following adaptation to repeated restraint. Neuroreport. 5: 1785-1788.
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  149. Haleem, D.J., 1993. Function specific supersensitivity of m-chlorophenyl piperazine-induced serotonergic neurotransmission in females compared to male rats. Life Sci. (USA), 52: PL279-PL284.
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  150. Haleem, D.J., 1992. Sex differences in neurochemical and behavioural effects of 8-hydroxy-2-(di-n-propylamino) tetralin. Life Sci. (USA) Pharmacol. Lett., 50: PL221-PL226.
  151. Haleem, D.J., 1992. Repeated corticosterone treatment attenuartes behavioural and neuroendocrine responses to 8-hydroxy-2-(di-n-propylaminotetralin) in rats. Life Sci. (USA) Pharmacol. Lett., 51: PL225-PL230.
  152. Haleem, D.J., G.A. Kennett and G.Curzon, 1990. Hippocampal 5-hydroxytryptamine synthesis is greater in female rats than in males and more decreased by the 5-HT1A agonist 8-OH-DPAT. J. Neural Transm. Gen. Sect., 79: 93-101.
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  153. Haleem, D.J., 1990. Injected tryptophan increases brain but plasma tryptophan levels more in ethanol treated rats. Life Sci. (USA), 47: 971-979.
  154. Haleem, D.J., G.A. Kennett, P. Whitton and G. Curzon, 1989. 8-OH-DPAT increases plasma corticosterone but not other 5-HT-1A receptor dependent responses more in females European. J. Pharmacol., 164: 435-443.
  155. Haleem, D.J., G.A. Kennett and G. Curzon, 1988. Adaptation of female rats to stress: Shift to male pattern by inhibition of corticosterone synthesis. Brain Res., 458: 339-347.