Dr. Zaheer Ul-Haq Qasmi
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Dr. Zaheer Ul-Haq Qasmi

Professor
University of Karachi, Pakistan

Highest Degree
Ph.D. in Chemistry from University of Karachi, Pakistan

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Area of Interest:

Chemistry
100%
Bioorganic Chemistry
62%
Medicinal Chemistry
90%
Phytochemistry
75%
Macromolecules
55%

Research Publications in Numbers

Books
8
Chapters
2
Articles
223
Abstracts
0

Selected Publications

  1. Usman, F., R. Khalil, Z. Ul-Haq, T. Nakpheng and T. Srichana, 2018. Bioactivity, safety and efficacy of amphotericin B nanomicellar aerosols using sodium deoxycholate sulfate as the lipid carrier. AAPS PharmSciTech. 10.1208%2Fs12249-018-1013-4.
    CrossRef  |  
  2. Ul-Haq, Z., S. Ashraf and M.M. Bkhaitan, 2018. Molecular dynamics simulations reveal structural insights into inhibitor binding modes and mechanism of casein kinase II inhibitors. J. Biomolecular Struct. Dynamics. 10.1080/07391102.2018.1450166.
    CrossRef  |  
  3. Shamim, S., K.M. Khan, U. Salar, F. Ali and M.A. Lodhi et al., 2018. 5-Acetyl-6-methyl-4-aryl-3, 4-dihydropyrimidin-2 (1H)-ones: As potent urease inhibitors; Synthesis, in vitro screening and molecular modeling study. Bioorganic Chem., 76: 37-52.
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  4. Shah, S., K. Javaid, H. Zafar, K.M. Khan and R. Khalil et al., 2018. Synthesis and in vitro and in Silico α-glucosidase inhibitory studies of 5-chloro-2-Aryl Benzo [d] thiazoles. Bioorganic Chem., 78: 269-279.
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  5. Hameed, A., R.M. Hafizur, N. Hussain, S.A. Raza and M. Rehman et al., 2018. Eriodictyol stimulates insulin secretion through cAMP/PKA signaling pathway in mice islets. Eur. J. Pharmacol., 820: 245-255.
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  6. Hafizur, R.M., K. Maryam, A. Hameed, S. Bano and S. Sumbul et al., 2018. Insulin releasing effect of some pure compounds from Moringa oleifera on mice islets. Med. Chem. Res., 27: 1408-1418.
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  7. Usman, F., Z. Ul-Haq, R. Khalil, K. Tinpun and T. Srichana, 2017. Pharmacologically safe nanomicelles of amphotericin b with lipids: Nuclear magnetic resonance and molecular docking approach. J. Pharm. Sci., 106: 3574-3582.
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  8. Ul-Haq, Z., J.S. Effendi, S. Ashraf and M.M. Bkhaitan, 2017. Atom and receptor based 3D QSAR models for generating new conformations from pyrazolopyrimidine as IL-2 inducible tyrosine kinase inhibitors. J. Mol. Graphics Modell., 74: 379-395.
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  9. Shah, M.A., R. Khalil, Z. Ul-Haq and P. Panichayupakaranant, 2017. α-Glucosidase inhibitory effect of rhinacanthins-rich extract from Rhinacanthus nasutus leaf and synergistic effect in combination with acarbose. J. Functional Foods, 36: 325-331.
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  10. Shah, M.A., H. Muhammad, Y. Mehmood, R. Khalil, Z. Ul-Haq and P. Panichayupakaranant, 2017. Superoxide scavenging and antiglycation activity of rhinacanthins-rich extract obtained from the leaves of Rhinacanthus nasutus. Pharm. Magazine, 13: 652-658.
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  11. Bkhaitan, M.M., A.Z. Mirza, A.N. Abdalla, H. Shamshad, Z. Ul‐Haq, M. Alarjah and A. Piperno, 2017. Reprofiling of full‐length phosphonated carbocyclic 2′‐oxa‐3′‐aza‐nucleosides toward antiproliferative agents: Synthesis, antiproliferative activity and molecular docking study. Chem. Biol. Drug Design, 90: 679-689.
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  12. Barakat, A., M.S. Islam, A.M. Al-Majid, S.M. Soliman and H.A. Ghabbour et al., 2017. Synthesis, molecular structure, spectral analysis and biological activity of new malonamide derivatives as α-glucosidase inhibitors. J. Mol. Struct., 1134: 253-264.
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  13. Barakat, A., M. Ali, A.M. Al-Majid, S. Yousuf, M.I. Choudhary, R. Khalil and Z. Ul-Haq, 2017. Synthesis of thiobarbituric acid derivatives: In vitro α-glucosidase inhibition and molecular docking studies. Bioorganic Chem., 75: 99-105.
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  14. Ul-Haq, Z., S. Usmani, S. Iqbal and S.R. Zia, 2016. In silico based investigation of dynamic variations in neprilysin (NEP and NEP2) proteins for extracting the point of specificity. Mol. BioSyst., 12: 1024-1036.
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  15. Ul-Haq, Z., S. Naz and M.A. Mesaik, 2016. Interleukin-4 receptor signaling and its binding mechanism: A therapeutic insight from inhibitors tool box. Cytokine Growth Factor Rev., 32: 3-15.
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  16. Ul-Haq, Z., S. Ashraf, A.M. Al-Majid and A. Barakat, 2016. 3D-QSAR studies on barbituric acid derivatives as urease inhibitors and the effect of charges on the quality of a model. Int. J. Molecular Sci., Vol. 17. 10.3390/ijms17050657.
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  17. Ul-Haq, Z., N. Khan, S.K. Zafar and S.T. Moin, 2016. Active site characterization and structure based 3D-QSAR studies on non-redox type 5-lipoxygenase inhibitors. Eur. J. Pharm. Sci., 88: 26-36.
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  18. Thadhani, V.M., A. Khan, Atia-tul-Wahab, S. Javaid, A. Shafqat, Zaheer-ul-Haq and M.I. Choudhary, 2016. Study of binding epitopes by STD-NMR spectroscopy and molecular docking of urease inhibitors from lichens. Lett. Drug Design Discovery, 13: 282-294.
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  19. Khan, K.M., M.A. Mesaik, O.M. Abdalla, F. Rahim and S. Soomro et al., 2016. The immunomodulation potential of the synthetic derivatives of benzothiazoles: Implications in immune system disorders through in vitro and in silico studies. Bioorganic Chem., 64: 21-28.
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  20. Barakat, A., M.S. Islam, A.M. Al-Majid, H.A. Ghabbour and S. Yousuf et al., 2016. Synthesis of pyrimidine-2, 4, 6-trione derivatives: Anti-oxidant, anti-cancer, α-glucosidase, β-glucuronidase inhibition and their molecular docking studies. Bioorganic Chem., 68: 72-79.
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  21. Zaheer Ul-Haq, M. Saeed, S.A. Halim and W. Khan, 2015. 3D Structure prediction of human β1-adrenergic receptor via threading-based homology modeling for implications in structure-based drug designing. PloS One, Vol. 10. 10.1371/journal.pone.0122223.
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  22. Ul-Haq, Z., S. Gul, S. Usmani, A. Wadood and W. Khan, 2015. Binding site identification and role of permanent water molecule of PIM-3 kinase: A molecular dynamics study. J. Mol. Graphics Modell., 62: 276-282.
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  23. Tanoli, S.A., N.U. Tanoli, T.M. Bondancia, S. Usmani and Zaheer Ul-Haq et al., 2015. Human serum albumin-specific recognition of the natural herbal extract of Stryphnodendron polyphyllum through STD NMR, hyphenations and docking simulation studies. RSC Adv., 5: 23431-23442.
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  24. Tanoli, N.U., S.A. Tanoli, A.G. Ferreira, S. Gul and Z. Ul-Haq, 2015. Evaluation of binding competition and group epitopes of acetylcholinesterase inhibitors by STD NMR, Tr-NOESY, DOSY and molecular docking: An old approach but new findings. MedChemComm, 6: 1882-1890.
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  25. Mabkhot, Y.N., F.D. Aldawsari, S.S. Al-Showiman, A. Barakat and T.B. Hadda et al., 2015. Synthesis, bioactivity, molecular docking and POM analyses of novel substituted thieno [2, 3-b] thiophenes and related congeners. Molecules, 20: 1824-1841.
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  26. Hussain, M.R.M., M. Baig, H.S.A. Mohamouvd, Z. Ulhaq and D.C. Hoessli et al., 2015. BRAF gene: From human cancers to developmental syndromes. Saudi J. Biol. Sci., 22: 359-373.
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  27. Halim, S.A. and Zaheer-ul-Haq, 2015. Structure based 3D-QSAR studies of interleukin-2 inhibitors: Comparing the quality and predictivity of 3D-QSAR models obtained from different alignment methods and charge calculations. Chemico-Biol. Interactions, 238: 9-24.
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  28. Barakat, A., A.M. Al-Majid, G. Lotfy, F. Arshad and S. Yousuf et al., 2015. Synthesis and dynamics studies of barbituric acid derivatives as urease inhibitors. Chem. Central J., Vol. 9. 10.1186/s13065-015-0140-1.
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  29. Ba-Salem, A.O., N. Ullah, M.N. Shaikh, M. Faiz and Zaheer Ul-Haq, 2015. Gd-complexes of new arylpiperazinyl conjugates of DTPA-Bis (amides): Synthesis, characterization and magnetic relaxation properties. Molecules, 20: 7807-7819.
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  30. Al-Aboudi, A., U. Mahcmood and Zaheer Ul-Haq, 2015. Synthesis and biological evaluation of new N-Arylidene-1-adamantylcarbohydrazides as potential cholinesterase inhibitors for Alzheimer's disease therapy. Acta Pharmacol. Sin., 36: 879-886.
  31. Akhtar, M.N., N.M. Sakeh, S. Zareen, S. Gul and K.M. Lo et al., 2015. Design and synthesis of chalcone derivatives as potent tyrosinase inhibitors and their structural activity relationship. J. Mol. Struct., 1085: 97-103.
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  32. Zaheer-ul-Haq, S.K. Zafar, N. Khan and U. Mahmood, 2014. Structure based 3D-QSAR studies on quinazoline derivatives as Platelets Derived Growth Factor (PDGFR) inhibitors. Med. Chem. Res., 23: 4070-4084.
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  33. Wadood, A., M. Riaz, R. Uddin and Zaheer-ul-Haq, 2014. In silico identification and evaluation of leads for the simultaneous inhibition of protease and helicase activities of HCV NS3/4A protease using complex based pharmacophore mapping and virtual screening. PLoS One, Vol. 9. 10.1371/journal.pone.0089109.
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  34. Wadood, A., M. Riaz, A. Ul Mulk, M. Khan and S.A. Haleem et al., 2014. Design of new and potent diethyl thiobarbiturates as urease inhibitors: A computational approach. Bioinformation, 10: 299-307.
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  35. Uddin, R., M. Saeed and Zaheer Ul-Haq, 2014. Molecular docking-and genetic algorithm-based approaches to produce robust 3D-QSAR models. Med. Chem. Res., 23: 2198-2206.
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  36. Tanoli, S.A.K., N.U. Tanoli, S. Usmani, Zaheer-ul-Haq and A.G. Ferreira, 2014. The exploration of interaction studies of smaller size, mostly ignored yet intrinsically inestimable molecules towards BSA: An example of STD and DOSY NMR. Cent. Eur. J. Chem., 12: 332-340.
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  37. Naz, A., H. Shamshad, Zaheer Ul Haq and F.A. Siddiqui, 2014. CoMFA and CoMSIA studies on a series of fluroquinolone derivatives for potential anti-inflammatory activity. Analytical Methods, 6: 6823-6831.
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  38. Mohamoud, H.S.A., M.R.M. Hussain, A.A. El-Harouni, N.A. Shaik and Z.U. Qasmi et al., 2014. First comprehensive in silico analysis of the functional and structural consequences of SNPs in human GalNAc-T1 gene. Comput. Math. Methods Med., Vol. 2014. 10.1155/2014/904052.
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  39. Mabkhot, Y.N., M.S. Al-Har, A. Barakat, F.D. Aldawsari, A. Aldalbahi and Zaheer Ul-Haq, 2014. Synthesis, anti-microbial and molecular docking studies of quinazolin-4 (3H)-one derivatives. Molecules, 19: 8725-8739.
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  40. Lodhi, M.A., S. Shams, M.I. Choudhary, A. Lodhi and Zaheer-ul-Haq et al., 2014. Structural basis of binding and rationale for the potent urease inhibitory activity of biscoumarins. BioMed. Res. Int., Vol. 2014. 10.1155/2014/935039.
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  41. Khan, K.M., N. Ambreen, M. Taha, S.A. Halim and Zaheer-ul-Haq et al., 2014. Structure-based design, synthesis and biological evaluation of β-Glucuronidase inhibitors. J. Comput. Aided Mol. Des., 28: 577-585.
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  42. Zaheer-ul-Haq, S. Usmani, U. Mahmood, M. Al-Rashida and G. Abbas, 2013. In silico analysis of chromone containing sulfonamide derivatives as human carbonic anhydrase inhibitors. Med. Chem., 9: 608-616.
    PubMed  |  Direct Link  |  
  43. Zaheer-ul-Haq, S. Usmani, H. Shamshad, U. Mahmood and S.A. Halim, 2013. A combined 3D-QSAR and docking studies for the In-silico prediction of HIV-protease inhibitors. Chem. Central J., Vol. 7. 10.1186/1752-153X-7-88.
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  44. Zafar, S., M.I. Choudhary, K. Dalvandi, U. Mahmood and Zaheer-ul-Haq, 2013. Molecular docking simulation studies on potent butyrylcholinesterase inhibitors obtained from microbial transformation of dihydrotestosterone. Chem. Cent. J., Vol. 7. 10.1186/1752-153X-7-164.
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  45. Wadood, A. and Zaheer-ulHaq, 2013. In silico identification of novel inhibitors against Plasmodium falciparum dihydroorate dehydrogenase. J. Mol. Graph. Modell., 40: 40-47.
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  46. Uddin, R., A. Naz, N. Akhtar and Zaheer-ul-Haq, 2013. Development of robust QSAR model using Rapid Overlay of Crystal Structures (ROCS) based alignment: A test case of Tubulin inhibitors. Med. Chem. Res., 22: 3229-3241.
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  47. Tanoli, S.A.K., N.U. Tanoli, T.M. Bondancia, S. Usmani and R. Kerssebaum et al., 2013. Crude to leads: A triple-pronged direct NMR approach in coordination with docking simulation. Analyst, 138: 5137-5145.
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  48. Rashid, U., I. Batool, A. Wadood, A. Khan, Zaheer-ul-Haq, M.I. Chaudhary and F.L. Ansari, 2013. Structure based virtual screening-driven identification of monastrol as a potent urease inhibitor. J. Mol. Graph. Modell., 43: 47-57.
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  49. Nazir, S., F.L. Ansari, T. Hussain, K. Mazhar and A.G. Muazzam et al., 2013. Brine shrimp lethality assay an effective prescreen: Microwave-assisted synthesis, BSL toxicity and 3DQSAR studies-based designing, docking and antitumor evaluation of potent chalcones. Pharmaceut. Biol., 51: 1091-1103.
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  50. Lodhi, M.A., Zaheer-ul-Haq, A. Wadood, S. Iqbal, K.M. Khan, Atta-ur-Rahman and M.I. Choudhary, 2013. Three-dimensional quantitative structure-activity relationship (CoMSIA) analysis of bis-coumerine analogues as urease inhibitors. Med. Chem. Res., 22: 498-504.
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  51. Khan, S., S.A. Halim, M. Kashif, A. Jabeen and M. Asif et al., 2013. In-vitro immunomodulatory and anti-cancerous activities of biotransformed products of Dianabol through Azadirachta indica and its molecular docking studies. Chem. Central J., Vol. 7. 10.1186/1752-153X-7-163.
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  52. Kalsoom, S., U. Rashid, A. Shaukat, O.M. Abdalla and K. Hussain et al., 2013. In vitro and in silico exploration of IL-2 inhibition by small drug-like molecules. Med. Chem. Res., 22: 5739-5751.
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  53. Hassan, S.F., U. Rashid, F.L. Ansari and Z. Ul-Haq, 2013. Bioisosteric approach in designing new monastrol derivatives: An investigation on their ADMET prediction using in silico derived parameters. J. Mol. Graphics Modell., 45: 202-210.
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  54. Halim, S.A., O.M. Abdalla, M.A. Mesaik, A. Wadood, Zaheer-ul-Haq and M. Kontoyianni, 2013. Identification of novel Interleukin-2 inhibitors through computational approaches. Mol. Divers., 17: 345-355.
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  55. Zaheer-ul-Haq, W. Khan, S.R. Zia and S. Iqbal, 2012. Structure-based 3D-QSAR models and dynamics analysis of novel N-benzyl pyridinone as p38α MAP kinase inhibitors for anticytokine activity. J. Mol. Graph. Modell., 36: 48-61.
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  56. Zaheer-ul-Haq, U. Mahmood and S. Reza, 2012. A combined 3D-QSAR and molecular docking strategy to understand the binding mechanism of V600EB-RAF inhibitors. Mol. Diversity, 16: 771-785.
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  57. Zaheer-ul-Haq, S. Iqbal and S.T. Moin, 2012. Dynamic changes in the secondary structure of ECE-1 and XCE account for their different substrate specificities. BMC Bioinform., Vol. 13. 10.1186/1471-2105-13-285.
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  58. Wadood, A., S.A. Ali, R. Sattar, M.A. Lodhi and Zaheer-ul‐Haq, 2012. A novel pharmacophore model to identify leads for simultaneous inhibition of anti‐coagulation and anti‐inflammatory activities of snake venom phospholipase A2. Chem. Biol. Drug Des., 79: 431-441.
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  59. Uddin, R., M.U. Lodhi and Zaheer-ul-Haq, 2012. Combined pharmacophore and 3D-QSAR study on a series of Staphylococcus aureus sortase A inhibitors. Chem. Biol. Drug Des., 80: 300-314.
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  60. Mesaik, M.A., A. Jabeen, S.A. Halim, A. Begum and A.S. Khalid et al., 2012. In silico and in vitro immunomodulatory studies on compounds of Lindelofia stylosa. Chem Biol Drug Des., 79: 290-299.
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  61. Lam, K.W., R. Uddin, C.Y. Liew, C.L. Tham and D.A. Israf et al., 2012. Synthesis and QSAR analysis of chalcone derivatives as nitric oxide inhibitory agent. Med. Chem. Res., 21: 1953-1966.
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  62. El Ashry, E.S.H., M.R. Amer, O.M. Abdalla, A.A. Aly and S. Soomro et al., 2012. Synthesis, biological evaluation and molecular docking studies of benzyl, alkyl and glycosyl [2-(arylamino)-4, 4-dimethyl-6-oxo-cyclohex-1-ene] carbodithioates, as potential immunomodulatory and immunosuppressive agents. Bioorg. Med. Chem., 20: 3000-3008.
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  63. Azam, S.S., R. Uddin, A.A.S. Syed and Zaheer-ul-Haq, 2012. Molecular docking studies of potent inhibitors of tyrosinase and α- Med. Chem Res., 21: 1677-1683.
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  64. Ansari, F.L, S. Kalsoom, Zaheer-ul-Haq, Z. Ali and F. Jabeen, 2012. In silico studies on 2,3-dihydro-1,5-benzothiazepines as cholinesterase inhibitors. Med. Chem. Res., 21: 2329-2339.
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  65. Zaheer-ul-Haq, U. Mahmood, S. Reza, R. Uddin and M. Aleem, 2011. Ligand-based 3D-QSAR studies of diaryl acyl-sulfonamide analogues as human umbilical vein endothelial cells inhibitors stimulated by VEGF. Chem. Biol. Drug Des., 77: 288-294.
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  66. Zaheer-ul-Haq, R. Uddin, L.K. Wai, A. Wadood and N.H. Lajis, 2011. Docking and 3D-QSAR modeling of cyclin-dependent kinase 5/p25 inhibitors. J. Mol. Model., 17: 1149-1161.
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  67. Zaheer-ul-Haq, R. Uddin and S. Gul, 2011. Optimization of structure based virtual screening protocols against thymidine monophosphate kinase inhibitors as antitubercular agents. Mol. Inform., 30: 851-862.
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  68. Zaheer-ul-Haq and W. Khan, 2011. Molecular and structural determinants of adamantyl susceptibility to HLA-DRs allelic variants: An in silico approach to understand the mechanism of MLEs. J. Comput. Aided Mol. Des., 25: 81-101.
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  69. Moin, S.T., T.S. Hofer, R. Sattar and Zaheer-ul-Haq, 2011. Molecular dynamics simulation of mammalian 15S-lipoxygenase with AMBER force field. Eur. Biophys. J., 40: 715-726.
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  70. Mahmood, U., S. Rashid, S.I. Ali, R. Parveen and Zaheer-ul-Haq et al., 2011. 3D-QSPR method of computational technique applied on red reactive dyes by using CoMFA strategy. Int. J. Mol. Sci., 12: 8862-8877.
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  71. Khan, K.M., M. Ali, A. Wadood, Zaheer-ul-Haq and M. Khan et al., 2011. Molecular modeling-based antioxidant arylidene barbiturates as urease inhibitors. J. Mol. Graph. Model., 30: 153-156.
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  72. Khan, K.M., F. Rahim, S.A. Halim, M. Taha and M. Khan et al., 2011. Synthesis of novel inhibitors of β-glucuronidase based on benzothiazole skeleton and study of their binding affinity by molecular docking. Bioorg. Med. Chem., 19: 4286-4294.
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  73. Zaheer-ul-Haq, W. Khan, S. Zarina, R. Sattar and S.T. Moin, 2010. Template-based structure prediction and molecular dynamics simulation study of two mammalian Aspartyl-tRNA synthetases. J. Mol. Graphics Modell., 28: 401-412.
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  74. Zaheer-ul-Haq, S.A. Halim, R. Uddin and J.D. Madura, 2010. Benchmarking docking and scoring protocol for the identification of potential acetylcholinesterase inhibitors. J. Mol. Graphics Modell., 28: 870-882.
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  75. Ul-Haq, Z., W. Khan, S. Kalsoom and F.L. Ansari, 2010. In silico modeling of the specific inhibitory potential of thiophene-2,3-dihydro-1,5-benzothiazepine against BChE in the formation of β-amyloid plaques associated with Alzheimer's disease. Theor. Biol. Med. Modell., Vol. 7. 10.1186/1742-4682-7-22.
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  76. Mesaik, M.A., S.A. Halim, Zaheer-ul-Haq, M.I. Choudhary and S. Shahnaz, 2010. Immunosuppressive activity of Buxidin and E‐Buxenone from Buxus hyrcana. Chem. Biol. Drug Design, 75: 310-317.
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  77. Lam, K.W., A. Syahida, Zaheer-ul-Haq, M.B.A. Rahman and N.H. Lajis, 2010. Synthesis and biological activity of oxadiazole and triazolothiadiazole derivatives as tyrosinase inhibitors. Bioorg. Med. Chem. Lett., 20: 3755-3759.
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  78. Khan, K.M., A. Wadood, M. Ali, Zaheer-ul-Haq and M.A. Lodhi et al., 2010. Identification of potent urease inhibitors via ligand-and structure-based virtual screening and in vitro assays. J. Mol. Graphics Modell., 28: 792-798.
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  79. Khan, I., S. Ali, S. Hameed, N.H. Rama and M.T. Hussain et al., 2010. Synthesis, antioxidant activities and urease inhibition of some new 1,2,4-triazole and 1,3,4-thiadiazole derivatives. Eur. J. Med. Chem., 45: 5200-5207.
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  80. Azam, S.S., Zaheer-ul-Haq and M.Q. Fatmi, 2010. Classical and QM/MM MD simulations of sodium(I) and potassium(I) ions in aqueous solution. J. Mol. Liquids, 153: 95-100.
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  81. Abid, O.U.R., T.M. Babar, F.I. Ali, S. Ahmed and A. Wadood et al., 2010. Identification of novel urease inhibitors by high-throughput virtual and in vitro screening. ACS Med. Chem. Lett., 1: 145-149.
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  82. Zaheer-ul-Haq, U. Mahmood and B. Jehangir, 2009. Ligand-based 3D-QSAR studies of physostigmine analogues as acetylcholinesterase inhibitors. Chem. Biol. Drug Design, 74: 571-581.
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  83. Zaheer-ul-Haq, H. Hadi, S.T. Moin and M.I. Choudhary, 2009. Molecular dynamics simulation of Axillaridine-A: A potent natural cholinesterase inhibitor. J. Enzyme Inhibition Med. Chem., 24: 1101-1105.
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  84. Zaheer-ul-Haq, A. Wadood and R. Uddin, 2009. CoMFA and CoMSIA 3D-QSAR analysis on hydroxamic acid derivatives as urease inhibitors. J. Enzyme Inhibition Med. Chem., 24: 272-278.
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  85. Zaheer-ul-Haq and S. Iqbal, 2009. Receptor-based 3D-QSAR study for recognizing true binding mode of mercaptoacyldipeptides at the active site of neutral endopeptidase. Med. Chem., 5: 50-65.
  86. Zaheer-ul-Haq and A. Wadood, 2009. Prediction of binding affinities for hydroxamic acid derivatives as urease inhibitors by molecular docking and 3D-QSAR studies. Lett. Drug Design Discovery, 6: 93-100.
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  87. Hussain, S., J. Gaffney, N. Ahmed, M. Slevin and M.I. Choudhary et al., 2009. An investigation of the kinetic and anti-angiogenic properties of plant glycoside inhibitors of thymidine phosphorylase. J. Asian Nat. Prod. Res., 11: 159-167.
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  88. Ansari, F.L., A. Wadood, A. Ullah, F. Iftikhar and Z. Ul-Haq, 2009. In silico studies of urease inhibitors to explore ligand-enzyme interactions. J. Enzyme Inhibition Med. Chem., 24: 151-156.
    PubMed  |  
  89. Zaheer-ul-Haq, R. Uddin, H. Yuan, P.A. Petukhov, M.I. Choudhary and J.D. Madura, 2008. Receptor-based modeling and 3D-QSAR for a quantitative production of the butyrylcholinesterase inhibitors based on genetic algorithm. J. Chem. Inform. Model, 48: 1092-1103.
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  90. Zaheer-ul-Haq, M.A. Lodhi, S.A. Nawaz, S. Iqbal and K.M. Khanet al., 2008. 3D-QSAR CoMFA studies on bis-coumarine analogues as urease inhibitors: A strategic design in anti-urease agents. Bioorg. Med. Chem., 16: 3456-3461.
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  91. Zaheer-ul-Haq, P. Dalal, N.N. Aronson Jr. and J.D. Madura, 2007. Family 18 chitolectins: Comparison of MGP40 and HUMGP39. Biochem. Biophys. Res. Commun., 359: 221-226.
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  92. Chaudhry, A.M.A., N. Akhtar, Z. Qasmi and M.A. Haleem, 2007. Computer aided drug design of NF-033 for aids treatment. Int. J. Biol. Biotech., 4: 335-346.
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  93. Mesaik, M.A., Zaheer-ul-Haq, S. Murad, Z. Ismail and N.R. Abdullah et al., 2006. Biological and molecular docking studies on coagulin-H: Human IL-2 novel natural inhibitor. Mol. Immunol., 43: 1855-1863.
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  94. Khan, K.M., Z. Ullah, M.A. Lodhi, M. Ali, M.I. Choudhary, Atta-ur-Rahman and Zaheer-ul-Haq, 2006. Successful computer guided planned synthesis of (4R)-thiazolidine carboxylic acid and its 2-substituted analogues as urease inhibitors. Mol. Divers., 10: 223-231.
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  95. Giliani, A.U., M.N. Ghayur, A. Khalid, Zaheer-ul-Haq, M.I. Choudhary and Atta-ur-Rahman, 2005. Presence of antispasmodic, antidiarrheal, antisecretory, calcium antagonist and acetylcholinesterase inhibitory steroidal alkaloids in Sarcococca saligna. Planta Med., 71: 120-125.
    Direct Link  |  
  96. Choudhary, M.I., S.A. Nawaz, Zaheer-ul-Haq, M.K. Azim and M.N. Ghayur et al., 2005. Juliflorine: A potent natural peripheral anionic-site-binding inhibitor of acetylcholinesterase with calcium-channel blocking potential, a leading candidate for Alzheimer's disease therapy. Biochem. Biophys. Res. Commun., 332: 1171-1179.
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  97. Choudhary, M.I., S.A. Nawaz, Zaheer-ul-Haq, M.A. Lodhi and M.N. Ghayur et al., 2005. Withanolides, A new class of natural cholinesterase inhibitors with calcium antagonistic properties. Biochem. Biophys. Res. Commun., 334: 276-287.
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  98. Khalid, A., Zaheer-ul-Haq, S. Anjum, M.R. Khan, Atta-ur-Rahman and M.I. Choudhary, 2004. Kinetics and structure-activity relationship studies on pregnane-type steroidal alkaloids that inhibit cholinesterases. Bioorg Med. Chem., 12: 1995-2003.
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  99. Khalid, A., Zaheer-ul-Haq, N. Ghayur, F. Feroz, Atta-ur-Rahman, A.H. Gilani and M.I. Choudhary, 2004. Cholinesterase inhibitory and spasmolytic potential of steroidal alkaloids. J. Steroid Biochem. Mol. Biol., 92: 477-484.
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  100. Atta-ur-Rahman, Zaheer-ul-Haq, F. Feroz, A. Khalid, S.A. Nawaz, M.R. Khan and M.I. Choudhary, 2004. New cholinesterase-inhibiting steroidal alkaloids from Sarcococca saligna. Helvetica Chimica Acta, 87: 439-448.
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  101. Atta-ur-Rahman, F. Feroz, I. Naeem, Zaheer-ul-Haq and M.R. Khan and S.A. Nawaz et al., 2004. New pegnane-type steroidal slkaloids from Sarcococca saligna and their cholinesterase inhibitory activity. Steroids, 69: 735-741.
  102. Anjum, S., Atta-ur-Rahman, M.I. Choudhary, A. Khalid, Zaheer-ul-Haq and F. Feroz, 2004. Interesting SAR studies of pregnane alkaloids isolated from genus Sarcococca against cholinesterase enzymes. Iran. J. Pharmaceut. Res., Vol. 3. .
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  103. Zaheer-ul-Haq, B. Wellenzohn, S. Tonmunphean, A. Khalid, M.I. Choudhary and B.M. Rode, 2003. 3D-QSAR studies on natural acetylcholinesterase inhibitors of Sarcococca saligna by comparative molecular field analysis (CoMFA). Bioorg Med. Chem. Lett., 13: 4375-4380.
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  104. Zaheer-ul-Haq, B. Wellenzohn, K.R. Liedl and B.M. Rode, 2003. Molecular docking studies of natural cholinesterase-inhibiting steroidal alkaloids from Sarcococca saligna. J. Med. Chem., 46: 5087-5090.
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  105. Ghayur, M.N., A.H. Gilani, A. Khalid, M.I. Choudhary, Z. Qasmi, S.K. Kalauni and Atta-ur-Rahman, 2003. The presence of calcium channel blocking and acetylcholinesterase inhibitory constituents in Sarcococca saligna. FASEB J., 17: A238-A238.
  106. Atta-ur-Rahman, F. Feroz, Zaheer-ul-Haq, S.A. Nawaz, M.R. Khan and M.I. Choudhary, 2003. New steroidal alkaloids from Sarcococca saligna. Nat. Prod. Res., 17: 235-241.
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  107. Atta-ur-Rahman, Zaheer-ul-Haq, A. Khalid, S. Anjum, M.R. Khan and M.I. Choudhary, 2002. Pregnane-type steroidal alkaloids of Sarcococca saligna: A new class of cholinesterase inhibitors. Helvetica Chimica Acta, 85: 678-688.