Dr. Salim Al-Rejaie
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Dr. Salim Al-Rejaie

Professor
King Saud University, Saudi Arabia

Highest Degree
Ph.D. in Pharmacology and Toxicology from East Carolina University, North Carolina, USA

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Area of Interest:

Biomedical Sciences
100%
Pharmacology
62%
Toxicology
90%
Histology
75%
Pharmaceutical Biotechnology
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
0
Abstracts
0

Selected Publications

  1. Asita, A.O., T. Rants’o, S. Magama and M. Taole, 2018. Evaluation of procavia capensis hyraceum used in traditional medicine for modulation of mutagen-induced genotoxicity. J. Med. Plants Res., 12: 209-216.
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  2. Abuohashish, H.M., D.A. Khairy, M.M. Abdelsalam, A. Alsayyah, M.M. Ahmed and S. Al-Rejaie, 2018. In-vivo assessment of the osteo-protective effects of eugenol in alveolar bone tissues. 2018 97: 1303-1310.
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  3. Fatani, A.J., S.S. Al-Rejaie, M.Y. Parmar, O.M. Ahmed, H.M. Abuohashish and M.M. Ahmed, 2017. Lutein attenuates diabetic-induced renal damage via inhibiting oxidative and nitrosative stresses. Progr. Nutr., 19: 57-66.
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  4. Al-Dosari, D., M. Ahmed, S. Al-Rejaie, A. Alhomida and M. Ola, 2017. Flavonoid naringenin attenuates oxidative stress, apoptosis and improves neurotrophic effects in the diabetic rat retina. Nutrients, 9: 1-13.
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  5. Abuohashish, H.M., M.M. Ahmed, D. Sabry, M.M. Khattab and S.S. Al-Rejaie, 2017. The ACE-2/Ang1-7/Mas cascade enhances bone structure and metabolism following angiotensin-II type 1 receptor blockade. Eur. J. Pharmacol., 807: 44-55.
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  6. Abuohashish, H.M., M.M. Ahmed, D. Sabry, M.M. Khattab and S.S. Al-Rejaie, 2017. Angiotensin (1-7) ameliorates the structural and biochemical alterations of ovariectomy-induced osteoporosis in rats via activation of ACE-2/Mas receptor axis. Scient. Rep., Vol. 7. 10.1038/s41598-017-02570-x.
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  7. Abuohashish, H.M., M.M. Ahmed, D. Sabry, M.M. Khattab and S.S. Al-Rejaie, 2017. ACE-2/Ang1-7/Mas cascade mediates ACE inhibitor, captopril, protective effects in estrogen-deficient osteoporotic rats. Biomed. Pharmacother., 92: 58-68.
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  8. Fatani, A.J., M.Y. Parmar, H.M. Abuohashish, M.M. Ahmed and S.S. Al-Rejaie, 2016. Protective effect of lutein supplementation on oxidative stress and inflammatory progression in cerebral cortex of streptozotocin-induced diabetes in rats. Neurochem. J., 10: 69-76.
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  9. Fatani, A.J., F.S. Alrojayee, M.Y. Parmar, H.M. Abuohashish, M.M. Ahmed and S.S. Al-Rejaie, 2016. Myrrh attenuates oxidative and inflammatory processes in acetic acid-induced ulcerative colitis. Exp. Ther. Med., 12: 730-738.
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  10. Alasmari, F., S.S. Al-Rejaie, S.D. AlSharari and Y. Sari, 2016. Targeting glutamate homeostasis for potential treatment of nicotine dependence. Brain Res. Bull., 121: 1-8.
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  11. AlSharari, S.D., S.S. Al-Rejaie, H.M. Abuohashish, M.M. Ahmed and M.M. Hafez, 2016. Rutin attenuates hepatotoxicity in high-cholesterol-diet-fed rats. Oxid. Med. Cell. Longevity, Vol. 2016. 10.1155/2016/5436745.
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  12. Ola, M.S., M.M. Ahmed, R. Ahmad, H.M. Abuohashish, S.S. Al-Rejaie and A.S. Alhomida, 2015. Neuroprotective effects of rutin in streptozotocin-induced diabetic rat retina. J. Mol. Neurosci., 56: 440-448.
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  13. Hafez, M.M., O.A. Al-Shabanah, S.S. Al-Rejaie, N.O. Al-Harbi and Z.K. Hassan et al., 2015. Increased hypermethylation of glutathione S-transferase P1, DNA-binding protein inhibitor, death associated protein kinase and paired box protein-5 genes in triple-negative breast cancer Saudi Females. Asian Pac. J. Cancer Prev., 16: 541-549.
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  14. Hafez, M.M., N.O. Al-Harbi, A.R. Al-Hoshani, K.A. Al-Hosaini and S.D. Al Shrari et al., 2015. Hepato-protective effect of rutin via IL-6/STAT3 pathway in CCl4-induced hepatotoxicity in rats. Biol. Res., Vol. 48. 10.1186/s40659-015-0022-y.
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  15. Hafez, M.M., A.R. Alhoshani, K.A. Al-Hosaini, S.D. Alsharari, S.S. Al Rejaie, M.M. Sayed-Ahmed, O.A. Al-Shabanah, 2015. SKP2/P27Kip1 pathway is associated with Advanced ovarian cancer in saudi patients. Asian. Pac. J. Cancer Prev., 16: 5807-5815.
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  16. Fatani, A.J., S.S. Al-Rejaie, H.M. Abuohashish, A. Al-Assaf, M.Y. Parmar and M.M. Ahmed, 2015. Lutein dietary supplementation attenuates streptozotocin-induced testicular damage and oxidative stress in diabetic rats. BMC Complement. Alternat. Med., Vol. 15. 10.1186/s12906-015-0693-5.
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  17. Fatani, A.J., S.S. Al Rejaie, H.M. Abuohashish, A. Al Assaf, M.Y. Parmar, M.S. Ola and M.M. Ahmed, 2015. Neuroprotective effects of gymnema sylvestre on streptozotocin-induced diabetic neuropathy in rats. Exp. Ther. Med., 9: 1670-1678.
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  18. Fatani, A.J., K.A. Al‐Hosaini, M.M. Ahmed, H.M. Abuohashish, M.Y. Parmar and S.S. Al‐Rejaie, 2015. Carvedilol attenuates inflammatory biomarkers and oxidative stress in a rat model of ulcerative colitis. Drug Dev. Res., 76: 204-214.
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  19. Al-Rejaie, S.S., H.M. Abuohashish, H.M. Ahmed, A.S. Arrejaie, A.M. Aleisa and S.D. AlSharari, 2015. Telmisartan inhibits hyperalgesia and inflammatory progression in a diabetic neuropathic pain model of Wistar rats. Neurosci., 20: 115-123.
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  20. Al-Rejaie, S.S., A.M. Aleisa, H.M. Abuohashish, M.Y. Parmar, M.S. Ola, A.A. Al-Hosaini and M.M. Ahmed, 2015. Naringenin neutralises oxidative stress and nerve growth factor discrepancy in experimental diabetic neuropathy. Neurol. Res., 37: 924-933.
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  21. Abuohashish, H.M., M.M Ahmed, S.S. Al-Rejaie and K.E.H. Eltahir, 2015. The antidepressant bupropion exerts alleviating properties in an ovariectomized osteoporotic rat model. Acta Pharm. Sin., 36: 209-220.
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  22. Ola, M.S., A.M. Aleisa, S.S. Al-Rejaie, H.M. Abuohashish, M.Y. Parmar, A.S. Alhomida and M.M. Ahmed, 2014. Flavonoid, morin inhibits oxidative stress, inflammation and enhances neurotrophic support in the brain of streptozotocin-induced diabetic rats. Neurol. Sci., 35: 1003-1008.
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  23. Hafez, M.M., O.A. Al-Shabanah, N.O. Al-Harbi, M.M. Al-Harbi, S.S. Al-Rejaie, S.M. Alsurayea and M.M. Sayed-Ahmed, 2014. Association between paraoxonases gene expression and oxidative stress in hepatotoxicity induced by CCl4. Oxid. Med. Cell Longev., Vol. 2014. 10.1155/2014/893212.
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  24. Aleisa, A.M., S.S. Al-Rejaie, H.M. Abuohashish, M.S. Ola, M.Y. Parmar and M.M. Ahmed, 2014. Pretreatment of Gymnema sylvestre revealed the protection against acetic acid-induced ulcerative colitis in rats. BMC Complement. Alternat. Med., Vol. 14. 10.1186/1472-6882-14-49.
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  25. Aleisa, A., S. Al-Rejaie, H. Abuohashish, M. Ola, M. Parmar and M. Ahmed, 2014. Gymnemasylvestre protects against experimentally-induced colitis via its anti-inflammatory and antioxidant properties in rats. BMC Complementary Altern. Med., 14: 49-50.
  26. AlSharari, S.D., S.S. Al-Rejaie, H.M. Abuohashish, A.M. Aleisa, M.Y. Parmar and M.M. Ahmed, 2014. Ameliorative potential of morin in streptozotocin-induced neuropathic pain in rats. Trop. J. Pharm. Res., 13: 1429-1436.
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  27. Parmar, M., P. Shah, V. Thakkar, S. Al-Rejaie and T. Gandhi, 2013. Hepatoprotective potential of methanolic extract of Vetiveria zizanioides roots against carbon tetrachlorideinduced acute liver damage in rats. Digest J. Nanomater. Biostructures, 8: 835-844.
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  28. Ola, M.S., M.M. Ahmed, H.M. Abuohashish, S.S. Al-Rejaie and A.S. Alhomida, 2013. Telmisartan ameliorates neurotrophic support and oxidative stress in the retina of streptozotocin-induced diabetic rats. Neurochem. Res., 38: 1572-1579.
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  29. Dar, M.S. and S. Al-Rejaie, 2013. Tonic modulatory role of mouse cerebellar α- and β-adrenergic receptors in the expression of ethanol-induced ataxia: Role of AC-cAMP. Behav. Brain Res., 241: 154-160.
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  30. Aleisa, A.M., S.S. Al-Rejaie, H.M. Abuohashish, M.M. Ahmed and M.Y. Parmar, 2013. Nephro-protective role of morin against experimentally induced diabetic nephropathy. Digest J. Nanomater. Biostruct., 8: 395-401.
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  31. Aleisa, A.M., H.M. Abuohashish, M.M. Ahmed, S.S. Al-Rejaie, O.A. Alkhamees and A.S. Alroujayee, 2013. Ameliorative effects of rutin and ascorbic acid combination on hypercholesterolemia-induced hepatotoxicity in female rats. Afr. J. Pharm. Pharmacol., 7: 280-288.
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  32. Al-Shabanah, O.A., M.M. Hafez, Z.K. Hassan, M.M. Sayed-Ahmed, W.N. Abozeed, S.S. Al-Rejaie and A.A. Alsheikh, 2013. Human papillomavirus genotyping and integration in ovarian cancer Saudi patients. Virol. J., Vol. 10. 10.1186/1743-422X-10-343.
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  33. Al-Rejaie, S.S., H.M. Abuohashish, M.M. Al-Enazi, A.H. Al-Assaf, M.Y. Parmar and M.M. Ahmed, 2013. Protective effect of naringenin on acetic acid-induced ulcerative colitis in rats. World J. Gastroenterol., 19: 5633-5644.
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  34. Al-Rejaie, S.S., A.M. Aleisa, M.M. Sayed-Ahmed, O.A. Al-Shabanah and H.M. Abuohashish et al., 2013. Protective effect of rutin on the antioxidant genes expression in hypercholestrolemic male Westar rat. BMC Complementary Altern. Med., Vol. 13. 10.1186/1472-6882-13-136.
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  35. Al-Rejaie, S.S., 2013. Thymoquinone treatment alleviate ovariectomy-induced hepatic oxidative damage in rats. J. Appl. Pharm. Sci., 3: 126-131.
  36. Abuohashish, H.M., S.S. Al-Rejaie, K.A. Al-Hosaini, M.Y. Parmar and M.M. Ahmed, 2013. Alleviating effects of morin against experimentally-induced diabetic osteopenia. Diabetol. Metabol. Syndrome, Vol. 5. 10.1186/1758-5996-5-5.
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  37. Sayed-Ahmed, M.M., M.M. Hafez, M.L. Aldelemy, A.M. Aleisa and S.S. Al-Rejaie et al., 2012. Downregulation of oxidative and nitrosative apoptotic signaling by L-carnitine in Ifosfamide-induced fanconi syndrome rat model. Oxidative Med. Cell. Longevity, Vol. 2012. 10.1155/2012/696704.
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  38. Sayed-Ahmed, M.M., M.M. Hafez, A.A. Al-Shabanah, S.S. Al-Rejaie and A.M. Aleisa et al., 2012. Increased expression of biological markers as potential therapeutic targets in Saudi women with triple-negative breast cancer. Tumori, 99: 557-566.
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  39. Parmar, M.Y., P.A. Shah, V.T. Thakkar, S.S. Al-Rejaie and T.R. Gandhi, 2012. Hepatoprotective effect of Amomum subulatum roxb seeds on carbon tetrachloride-induced liver damage in rats. J. Pharam., 2: 38-43.
  40. Moussa, I.M., M.H. Ashgan, A.M. Aleisa, A.A. Al-Arfaj and S.A. Rejaie, 2012. Evaluation of the protective efficacy of immunoglobulin Y (IgY- antibodies) prepared against Walterinnesia aegyptia snake venom in Saudi Arabia. Afr. J. Biotechnol., 11: 13726-13731.
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  41. Moussa, I.M., A.M. Hessan, A.M. Aleisa, A.A. Al-Arfaj, M.M. Salem-Bekhit and S.A. Alrejai, 2012. Protective efficacy of immunoglobulins Y prepared against Cerastes cerastes snake venom in the Kingdom of Saudi Arabia. Saudi Med. J., 33: 846-851.
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  42. Hafez, M.M., Z.K. Hassan, A.R. Zekri, A.A. Gaber, S.S. Al-Rejaie, M.M. Sayed-Ahmed and O.A. Al-Shabanah, 2012. MicroRNAs and metastasis-related gene expression in egyptian breast cancer patients. Asian Pac. J. Cancer Prev., 13: 591-598.
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  43. Al-Shabanah, O.A., A.M. Aleisa, M.M. Hafez, S.S. Al-Rejaie and A.A. Al-Yahya et al., 2012. Desferrioxamine attenuates doxorubicin-induced acute cardiotoxicity through TGF-β/Smad p53 pathway in rat model. Oxidative Med. Cell. Longevity,. 10.1155/2012/619185.
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  44. Al-Rejaie, S.S., H.M. Abuohashish, O.A. Alkhamees, A.M. Aleisa and A.S. Alroujayee, 2012. Gender difference following high cholesterol diet induced renal injury and the protective role of rutin and ascorbic acid combination in wistar albino rats. Lipids Health Dis., 11: 1-10.
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  45. Al-Rejaie, S.S., H.M. Abuohashish, M.M. Ahmed, A.M. Aleisa, A.S. Alroujayee and O.A. Alkhamees, 2012. Immobilization stress-induced oxidative damage and its amelioration with green and black teas. Afr. J. Pharm. Pharmacol., 6: 538-545.
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  46. Al-Rejaie, S.S., H.M. Abuohashish, M.M. Ahmed, A.M. Aleisa and O. Alkhamees, 2012. Possible biochemical effects following inhibition of ethanol-induced gastric mucosa damage by Gymnema sylvestre in male Wistar albino rats. Pharm. Biol., 50: 1542-1550.
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  47. Al-Rejaie, S.S., 2012. Effect of oleo-gum-resin on ethanol-induced hepatotoxicity in rats. J. Med. Sci., 12: 1-9.
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  48. Mounir, M.S.B., M.I.M. Ihab, M.A.M.E. Muharram and A. Salim, 2011. Increasing prevalence of high-level gentamicin resistant enterococci: An emerging clinical problem. Afr. J. Microbiol. Res., 5: 5713-5720.
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  49. Mohamed, M., L.M. Moussa, K.F. Mohamed, A. Samir and E.A. Nasr et al., 2011. Bactec mgit 960 tm system for screening of Mycobacterium tuberculosis complex among cattle. Afr. J. Biotechnol., 10: 13919-13923.
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  50. Aleisa, A.M., G. Helal, I.A. Alhaider, K.H. Alzoubi and M. Srivareerat et al., 2011. Acute nicotine treatment prevents rem sleep deprivation‐induced learning and memory impairment in rat. Hippocampus, 21: 899-909.
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  51. Sayed-Ahmed, M.M., O.A. Al-Shabanah, M.M. Hafez, A.M. Aleisa and S.S. Al-Rejaie, 2010. Inhibition of gene expression of heart fatty acid binding protein and organic cation/carnitine transporter in doxorubicin cardiomyopathic rat model. Eur. J. Pharmacol., 640: 143-149.
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  52. Sayed-Ahmed, M.M., A.M. Aleisa, S.S. Al-Rejaie, A.A. Al-Yahya, O.A. Al-Shabanah, M.M. Hafez and M.N. Nagi, 2010. Thymoquinone attenuates diethylnitrosamine induction of hepatic carcinogenesis through antioxidant signaling. Oxidative Med. Cell. Longevity, 3: 254-261.
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  53. Mansour, M.A., S.A. Bekheet, S.S. Al‐Rejaie, O.A. Al‐Shabanah, T.A. Al‐Howiriny, A.C. Al‐Rikabi and A.A. Abdo, 2010. Ginger ingredients inhibit the development of diethylnitrosoamine induced premalignant phenotype in rat chemical hepatocarcinogenesis model. Biofactors, 36: 483-490.
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  54. Al-Shabanah, O.A., M.M. Hafez, M.M. Al-Harbi, Z.K. Hassan, S.S. Al-Rejaie, Y.A. Asiri and M.M. Sayed-Ahmed, 2010. Doxorubicin toxicity can be ameliorated during antioxidant L-carnitine supplementation. Oxid. Med. Cell. Longev., 3: 428-433.
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  55. Al-Shabanah, O.A., A.M. Aleisa, A.A. Al-Yahya, S.S. Al-Rejaie, S.A. Bakheet, A.G. Fatani and M.M. Sayed-Ahmed, 2010. Increased urinary losses of carnitine and decreased intramitochondrial coenzyme a in gentamicin-induced acute renal failure in rats. Nephrol. Dial. Trans., 25: 69-76.
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  56. Helal, G.K., A.M. Aleisa, O.K. Helal, S.S. Al-Rejaie, A.A. Al-Yahya, A.A. Al-Majed and O.A. Al-Shabanah, 2009. Metallothionein induction reduces caspase-3 activity and TNFα levels with preservation of cognitive function and intact hippocampal neurons in carmustine-treated rats. Oxid. Med. Cell. Longevity, 2: 26-35.
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  57. Attia, S.M., A.M. Aleisa, S.A. Bakheet, A.A. Al‐Yahya, S.S. Al‐Rejaie, A.E. Ashour and O.A. Al‐Shabanah, 2009. Molecular cytogenetic evaluation of the mechanism of micronuclei formation induced by camptothecin, topotecan, and irinotecan. Environ. Mol. Mutagen., 50: 145-151.
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  58. Al-Rejaie, S.S., A.M. Aleisa, A.A. Al-Yahya, S.A. Bakheet and A. Alsheikh et al., 2009. Progression of diethylnitrosamine-induced hepatic carcinogenesis in carnitine-depleted rats. World J. Gastroenterol., 15: 1373-1380.
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  59. Al-Rejaie, S.S., 2009. Inhibition of ethanol-induced gastric mucosal damage by carvedilol in male wistar albino rats: Possible biochemical changes. Int. J. Pharmacol., 5: 146-154.
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  60. Al-Rejaie, S.S., 2009. Effect of green and black teas on immobilization induced stress in male wistar albino rats. Int. J. Pharmacol., 5: 137-145.
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  61. Abd-Allah, A.R., K.H. Gouda, A.A. Abdulaziz, M.A. Abdulaziz, S.A. Salim and A.A. Saleh, 2009. Pro-inflammatory and oxidative stress pathways which compromise sperm motility and survival may be altered by L-carnitine. Oxid. Med. Cell. Longev., 2: 73-81.
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  62. Taslim, N., S. Al-Rejaie and M.S. Dar, 2008. Attenuation of ethanol-induced ataxia by α4β2 nicotinic acetylcholine receptor subtype in mouse cerebellum: A functional interaction. Neurosci., 157: 204-213.
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  63. Mansour, M.A., S.A. Bakheet, A.M. Aleisa, S.S. Al-Rejaie, A.A. AL-Yahya, M. El-Ameen and O.A. Al-Shabanah, 2008. Protective effect of 6-gingerol against cardiotoxicity induced by doxorubicin. Open Pharmacol. J., 2: 20-23.
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  64. Aleisa, A.M., S.S. Al-Rejaie, S.A. Bakheet, A.M. Al-Bekairi and O.A. Al-Shabanah et al., 2008. Protective effect of metformin on cardiac and hepatic toxicity induced by adriamycin in swiss albino mice. Asian J. Biochem., 3: 99-108.
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  65. Aleisa, A.M., S.S. Al-Rejaie, S.A. Bakheet, A.M. Al-Bekari and A.M. Al-Shabanah et al., 2007. Effect of metformin on clastogenic and biochemical changes induced by adriamycin in Swiss albino mice. Mutat Res., 634: 93-100.
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  66. Aleisa, A.M., A.A. Al-Majed, A.A. Al-Yahya, S.S. Al-Rejaie, S.A. Bakheet, O.A. Al-Shabanah and M.M. Sayed-Ahmed, 2007. Reversal of cisplatin-induced carnitine deficiency and energy starvation by propionyl-L-carnitine in rat kidney tissues. Clin. Exp. Pharmacol. Physiol., 34: 1252-1259.
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  67. Al‐Rejaie, S. and M.S. Dar, 2006. Behavioral interaction between nicotine and ethanol: Possible modulation by mouse cerebellar glutamate. Alcohol.: Clin. Exp. Res., 30: 1223-1233.
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  68. Al-Rejaie, S. and M.S. Dar, 2006. Possible role of mouse cerebellar nitric oxide in the behavioral interaction between chronic intracerebellar nicotine and acute ethanol administration: Observation of cross-tolerance. Neurosci., 138: 575-585.
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  69. Al-Rejaie, S. and M.S. Dar, 2006. Antagonism of ethanol ataxia by intracerebellar nicotine: Possible modulation by mouse cerebellar nitric oxide and cGMP. Brain Res. Bull., 69: 187-196.
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  70. Al-Majed, A.A., M.M. Sayed-Ahmed, A.A. Al-Yahya, A.M. Aleisa, S.S. Al-Rejaie and O.A. Al-Shabanah, 2006. Propionyl-L-carnitine prevents the progression of cisplatin-induced cardiomyopathy in a carnitine-depleted rat model. Pharmacol. Res., 53: 278-286.
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