Dr. Ayman Moawad Mahmoud
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Dr. Ayman Moawad Mahmoud

Associate Professor & HOD
Department of Biotechnology, Faculty of Science, Research Institute of Medicinal & Aromatic Plants, Beni-Suef University, Egypt

Highest Degree
Ph.D. in Physiology from Beni-Suef University, Egypt

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Area of Interest:

Biomedical Sciences
100%
Oxidative Stress
62%
Obesity
90%
Cardiovascular Diseases
75%
Diabetes
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
153
Abstracts
0

Selected Publications

  1. Hassanein, E.H.M., G.A. Sayed, A.M. Alzoghaibi, A.S. Alammar and B.A. Abdel-Wahab et al., 2023. Azithromycin mitigates cisplatin-induced lung oxidative stress, inflammation and necroptosis by upregulating SIRT1, PPARγ, and Nrf2/HO-1 signaling. Pharmaceuticals, Vol. 16. 10.3390/ph16010052.
    CrossRef  |  Direct Link  |  
  2. Sarawi, W.S., A.M. Alhusaini, L.M. Fadda, H.A. Alomar and A.B. Albaker et al., 2022. Nano-curcumin prevents copper reproductive toxicity by attenuating oxidative stress and inflammation and improving Nrf2/HO-1 signaling and pituitary-gonadal axis in male rats. Toxics, Vol. 10. 10.3390/toxics10070356.
    CrossRef  |  Direct Link  |  
  3. El-Bab, A.F.F., S.A.M. Saghir, I.A. Abu El-Naser, S.M.M. Abo El-Kheir and M.F. Abdel-Kader et al., 2022. The effect of dietary Saccharomyces cerevisiae on growth performance, oxidative status, and immune response of sea bream (Sparus aurata). Life, Vol. 12. 10.3390/life12071013.
    CrossRef  |  Direct Link  |  
  4. Atwa, A.M., O.A.M. Abd El-Ghafar, E.H.M. Hassanein, S.E. Mahdi and G.A. Sayed et al., 2022. Candesartan attenuates cisplatin-induced lung injury by modulating oxidative stress, inflammation, and TLR-4/NF-κB, JAK1/STAT3, and Nrf2/HO-1 signaling. Pharmaceuticals, Vol. 15. 10.3390/ph15101222.
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  5. Alanezi, A.A., A.F. Almuqati, M.A. Alfwuaires, F. Alasmari, N.I. Namazi, O.Y. Althunibat and A.M. Mahmoud, 2022. Taxifolin prevents cisplatin nephrotoxicity by modulating Nrf2/HO-1 pathway and mitigating oxidative stress and inflammation in mice. Pharmaceuticals, Vol. 15. 10.3390/ph15111310.
    CrossRef  |  Direct Link  |  
  6. Al-Amarat, W., M.H. Abukhalil, R.S. Alruhaimi, H.A. Alqhtani and N. Aldawood et al., 2022. Upregulation of Nrf2/HO-1 signaling and attenuation of oxidative stress, inflammation, and cell death mediate the protective effect of apigenin against cyclophosphamide hepatotoxicity. Metabolites, Vol. 12. 10.3390/metabo12070648.
    CrossRef  |  Direct Link  |  
  7. Ajarem, J.S., A.K. Hegazy, G.A. Allam, A.A. Allam, S.N. Maodaa and A.M. Mahmoud, 2022. Heavy metal accumulation, tissue injury, oxidative stress, and inflammation in dromedary camels living near petroleum industry sites in Saudi Arabia. Animals, Vol. 12. 10.3390/ani12060707.
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  8. Ranneh, Y., A.M. Mahmoud, A. Fadel, M. Albujja, A.M. Akim, H.A. Hamid and H. Khazaai, 2021. Acute inflammation and oxidative stress induced by lipopolysaccharide and the ameliorative effect of stingless bee honey. Comb. Chem. High Throughput Screening, 24: 744-757.
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  9. Ajarem, J.S., A.K. Hegazy, G.A. Allam, A.A. Allam, S.N. Maodaa and A.M. Mahmoud, 2021. Effect of visnagin on altered steroidogenesis and spermatogenesis, and testicular injury induced by the heavy metal lead. Comb. Chem. High Throughput Screening, 24: 758-766.
    CrossRef  |  Direct Link  |  
  10. Hroob, A.M.A., S.A.M. Saghir, A.A. Almaiman, O.S.A. Alsalahi and A.S. Al-Wajeeh et al., 2020. Prevalence and association of transfusion transmitted infections with ABO and RH blood groups among blood donors at the national blood bank, amman, Jordan. Medicina, Vol. 56. 10.3390/medicina56120701.
    CrossRef  |  Direct Link  |  
  11. Ranneh, Y., A.M. Akim, H.A. Hamid, H. Khazaai, A. Fadel and A.M. Mahmoud, 2019. Stingless bee honey protects against lipopolysaccharide induced-chronic subclinical systemic inflammation and oxidative stress by modulating Nrf2, NF-κB and p38 MAPK. Nutr. Metab., Vol. 16. 10.1186/s12986-019-0341-z.
    CrossRef  |  Direct Link  |  
  12. Mohamed, H.M. and A.M. Mahmoud, 2019. Chronic exposure to the opioid tramadol induces oxidative damage, inflammation and apoptosis and alters cerebral monoamine neurotransmitters in rats. Biomed. Pharmacother., 110: 239-247.
    CrossRef  |  Direct Link  |  
  13. Mahmoud, A.M., W.G. Hozayen, I.H. Hasan, E. Shaban and M. Bin-Jumah, 2019. Umbelliferone ameliorates CCl4-induced liver fibrosis in rats by upregulating PPARγ and attenuating oxidative stress, inflammation and TGF-β1/Smad3 signaling. Inflammation, (In Press). 10.1007/s10753-019-00973-8.
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  14. Mahmoud, A.M., R.J.H. Bautista, M.A. Sandhu and O.E. Hussein, 2019. Beneficial effects of citrus flavonoids on cardiovascular and metabolic health. Oxid. Med. Cell. Longevity, Vol. 2019. 10.1155/2019/5484138.
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  15. Hozayen, W.G., A.M. Mahmoud, E.M. Desouky, E.S. El-Nahass, H.A. Soliman and A.A. Farghali, 2019. Cardiac and pulmonary toxicity of mesoporous silica nanoparticles is associated with excessive ROS production and redox imbalance in Wistar rats. Biomed. Pharmacother., 109: 2527-2538.
    CrossRef  |  PubMed  |  Direct Link  |  
  16. Bautista, R.J.H., A.M. Mahmoud, M. Konigsberg and N.E.L.D. Guerrero, 2019. Obesity: Pathophysiology, monosodium glutamate-induced model and anti-obesity medicinal plants. Biomed. Pharmacother., 111: 503-516.
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  17. Althunibat, O.Y., A.M. Al Hroob, M.H. Abukhalil, M.O. Germoush, M. Bin-Jumah and A.M. Mahmoud, 2019. Fisetin ameliorates oxidative stress, inflammation and apoptosis in diabetic cardiomyopathy. Life Sci., 221: 83-92.
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  18. Allam, A.A., S.I. Othman and A.M. Mahmoud, 2019. Deleterious effects of perinatal exposure to potassium bromate on the development of offspring of Swiss mice. Toxicol. Ind. Health, 35: 63-78.
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  19. AlHaithloul, H.A., M.F. Alotaibi, M. Bin-Jumah, H. Elgebaly and A.M. Mahmoud, 2019. Olea europaea leaf extract up-regulates Nrf2/ARE/HO-1 signaling and attenuates cyclophosphamide-induced oxidative stress, inflammation and apoptosis in rat kidney. Biomed. Pharmacother., 111: 676-685.
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  20. Al Hroob, A.M., M.H. Abukhalil, O.E. Hussein and A.M. Mahmoud, 2019. Pathophysiological mechanisms of diabetic cardiomyopathy and the therapeutic potential of epigallocatechin-3-gallate. Biomed. Pharmacother., 109: 2155-2172.
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  21. Mahmoud, A.M., M.O. Germoush, K.M. Al-Anazi, A.H. Mahmoud, M.A. Farah and A.A. Allam, 2018. Commiphora molmol protects against methotrexate-induced nephrotoxicity by up-regulating Nrf2/ARE/HO-1 signaling. Biomed. Pharmacother., 106: 499-509.
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  22. Jimenez, R., M. Toral, M. Gomez-Guzman, M. Romero, M. Sanchez, A.M. Mahmoud and J. Duarte, 2018. The role of Nrf2 signaling in PPARβ/δ-mediated vascular protection against hyperglycemia-induced oxidative stress. Oxid. Med. Cell. Longevity, Vol. 2018. 10.1155/2018/5852706.
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  23. Germoush, M.O., S.I. Othman, M.A. Al-Qaraawi, H.M. Al-Harbi and O.E. Hussein et al., 2018. Umbelliferone prevents oxidative stress, inflammation and hematological alterations and modulates glutamate-nitric oxide-cGMP signaling in hyperammonemic rats. Biomed. Pharmacother., 102: 392-402.
    CrossRef  |  Direct Link  |  
  24. Fadel, A., J. Ashworth, A. Plunkett, A.M. Mahmoud, Y. Ranneh and W. Li, 2018. Improving the extractability of arabinoxylans and the molecular weight of wheat endosperm using extrusion processing. J. Cereal Sci., 84: 55-61.
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  25. Fadel, A., A.M. Mahmoud, J.J. Ashworth, W. Li, Y.L. Ng and A. Plunkett, 2018. Health-related effects and improving extractability of cereal arabinoxylans. Int. J. Biol. Macromol., 109: 819-831.
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  26. Fadel, A., A. Plunkett, J. Ashworth, A.M. Mahmoud, Y. Ranneh, M. El Mohtadi and W. Li, 2018. The effect of extrusion screw-speed on the water extractability and molecular weight distribution of arabinoxylans from defatted rice bran. J. Food Sci. Technol., 55: 1201-1206.
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  27. Elgebaly, H.A., N.M. Mosa, M. Allach, K.F. El-Massry, A.H. El-Ghorab, A.M. Al Hroob and A.M. Mahmoud, 2018. Olive oil and leaf extract prevent fluoxetine-induced hepatotoxicity by attenuating oxidative stress, inflammation and apoptosis. Biomed. Pharmacother., 98: 446-453.
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  28. Al-Rasheed, N.M., N.M. Al-Rasheed, Y.A. Bassiouni, I.H. Hasan, M.A. Al-Amin, H.N. Al-Ajmi and A.M. Mahmoud, 2018. Simvastatin ameliorates diabetic nephropathy by attenuating oxidative stress and apoptosis in a rat model of streptozotocin-induced type 1 diabetes. Biomed. Pharmacother., 105: 290-298.
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  29. Al-Otaibi, F.S., J.S. Ajarem, M.A. Abdel-Maksoud, S. Maodaa, A.A. Allam, G.I. Al-Basher and A.M. Mahmoud, 2018. Stone quarrying induces organ dysfunction and oxidative stress in Meriones libycus. Toxicol. Ind. Health, 34: 679-692.
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  30. Al-Basher, G.I., H. Aljabal, R.S. Almeer, A.A. Allam and A.M. Mahmoud, 2018. Perinatal exposure to energy drink induces oxidative damage in the liver, kidney and brain and behavioral alterations in mice offspring. Biomed. Pharmacother., 102: 798-811.
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  31. Al Hroob, A.M., M.H. Abukhalil, R.D. Alghonmeen and A.M. Mahmoud, 2018. Ginger alleviates hyperglycemia-induced oxidative stress, inflammation and apoptosis and protects rats against diabetic nephropathy. Biomed. Pharmacother., 106: 381-389.
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  32. Ahmed, O., H. Fahim, A. Mahmoud and E. Ahmed, 2018. Bee venom and hesperidin effectively mitigate complete Freund’s adjuvant-induced arthritis via immunomodulation and enhancement of antioxidant defense system. Arch. Rheumatol., 33: 198-212.
    CrossRef  |  PubMed  |  Direct Link  |  
  33. Satta, S., A.M. Mahmoud, F.L. Wilkinson, M.Y. Alexander and S.J. White, 2017. The role of Nrf2 in cardiovascular function and disease. Oxid. Med. Cell. Longevity, Vol. 2017. 10.1155/2017/9237263.
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  34. Sarem, Z., C. Bumke-Vogt, A.M. Mahmoud, B. Assefa and M.O. Weickert et al., 2017. Glucagon decreases IGF-1 bioactivity in humans, independently of insulin, by modulating its binding proteins. J. Clin. Endocrinol. Metab., 102: 3480-3490.
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  35. Mahmoud, A.M., W.G. Hozayen and S.M. Ramadan, 2017. Berberine ameliorates methotrexate-induced liver injury by activating Nrf2/HO-1 pathway and PPARγ and suppressing oxidative stress and apoptosis in rats. Biomed. Pharmacother., 94: 280-291.
    CrossRef  |  Direct Link  |  
  36. Mahmoud, A.M., S.M. Abd El-Twab and E.S. Abdel-Reheim, 2017. Consumption of polyphenol-rich Morus alba leaves extract attenuates early diabetic retinopathy: The underlying mechanism. Eur. J. Nutr., 56: 1671-1684.
    CrossRef  |  Direct Link  |  
  37. Mahmoud, A.M., S. Alqahtani, S.I. Othman, M.O. Germoush and O.E. Hussein et al., 2017. Commiphora molmol modulates glutamate-nitric oxide-cGMP and Nrf2/ARE/HO-1 pathways and attenuates oxidative stress and hematological alterations in hyperammonemic rats. Oxid. Med. Cell. Longevity, Vol. 2017. 10.1155/2017/7369671.
    CrossRef  |  Direct Link  |  
  38. Mahmoud, A.M., O.E. Hussein, W.G. Hozayen and S.M. Abd El-Twab, 2017. Methotrexate hepatotoxicity is associated with oxidative stress, and down-regulation of PPARγ and Nrf2: Protective effect of 18β-glycyrrhetinic acid. Chemico-Biol. Interact., 270: 59-72.
    CrossRef  |  Direct Link  |  
  39. Mahmoud, A.M., M.Y. Alexander, Y. Tutar, F.L. Wilkinson and A. Venditti, 2017. Oxidative stress in metabolic disorders and drug-induced injury: The potential role of Nrf2 and PPARs activators. Oxid. Med. Cell. Longevity, Vol. 2017. 10.1155/2017/2508909.
    CrossRef  |  Direct Link  |  
  40. Mahmoud, A.M., M.O. Germoush, M.F. Alotaibi and O.E. Hussein, 2017. Possible involvement of Nrf2 and PPARγ up-regulation in the protective effect of umbelliferone against cyclophosphamide-induced hepatotoxicity. Biomed. Pharmacother., 86: 297-306.
    CrossRef  |  Direct Link  |  
  41. Mahmoud, A.M., M.M. Abdel-Rahman, N.A. Bastawy and H.M. Eissa, 2017. Modulatory effect of berberine on adipose tissue PPARγ, adipocytokines and oxidative stress in high fat diet/streptozotocin-induced diabetic rats. J. Applied Pharmaceut. Sci., 7: 1-10.
    CrossRef  |  Direct Link  |  
  42. Mahmoud, A.M., H.M. Mohammed, S.M. Khadrawy and S.R. Galaly, 2017. Hesperidin protects against chemically induced hepatocarcinogenesis via modulation of Nrf2/ARE/HO-1, PPARγ and TGF-β1/Smad3 signaling and amelioration of oxidative stress and inflammation. Chemico-Biol. Interact., 277: 146-158.
    CrossRef  |  Direct Link  |  
  43. Mahmoud, A.M., F.L. Wilkinson, E.M. McCarthy, D. Moreno-Martinez and A. Langford-Smith et al., 2017. Endothelial microparticles prevent lipid-induced endothelial damage via Akt/eNOS signaling and reduced oxidative stress. FASEB J., 31: 4636-4648.
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  44. Mahmoud, A.M., F.L. Wilkinson, A.M. Jones, J.A. Wilkinson, M. Romero, J. Duarte and M.Y. Alexander, 2017. A novel role for small molecule glycomimetics in the protection against lipid-induced endothelial dysfunction: Involvement of Akt/eNOS and Nrf2/ARE signaling. Biochim. Biophys. Acta (BBA)-Gen. Subj., 1861: 3311-3322.
    CrossRef  |  Direct Link  |  
  45. Mahmoud, A.M., A.R. Zaki, M.E. Hassan and G. Mostafa-Hedeab, 2017. Commiphora molmol resin attenuates diethylnitrosamine/phenobarbital-induced hepatocarcinogenesis by modulating oxidative stress, inflammation, angiogenesis and Nrf2/ARE/HO-1 signaling. Chemico-Biol. Interact., 270: 41-50.
    CrossRef  |  Direct Link  |  
  46. Mahmoud, A.M., 2017. Exercise amaliorates metabolic disturbances and oxidative stress in diabetic cardiomyopathy: Possible underlying mechanisms. Adv. Exp. Med. Biol., 999: 207-230.
    CrossRef  |  PubMed  |  Direct Link  |  
  47. Mahmoud, A.M. and S.M. Abd El-Twab, 2017. Caffeic acid phenethyl ester protects the brain against hexavalent chromium toxicity by enhancing endogenous antioxidants and modulating the JAK/STAT signaling pathway. Biomed. Pharmacother., 91: 303-311.
    CrossRef  |  Direct Link  |  
  48. Hozayen, W.G., S.M. Ramadan, A. Fadel and A.M. Mahmoud, 2017. Berberine mitigates methotrexate-induced oxidative stress and inflammation in the cerebrum of rats. J. Applied Pharmaceut. Sci., 7: 43-49.
    CrossRef  |  Direct Link  |  
  49. Hamed, A.I., R.B. Said, A.S. Al-Ayed, J. Moldoch and U.A. Mahalel et al., 2017. Fingerprinting of strong spermatogenesis steroidal saponins in male flowers of Phoenix dactylifera (date palm) by LC-ESI-MS. Nat. Prod. Res., 31: 2024-2031.
    CrossRef  |  Direct Link  |  
  50. Assefa, B., A.M. Mahmoud, A.F. Pfeiffer, A.L. Birkenfeld, J. Spranger and A.M. Arafat, 2017. Insulin-like Growth Factor (IGF) binding protein-2, independently of IGF-1, induces GLUT-4 translocation and glucose uptake in 3T3-L1 adipocytes. Oxid. Med. Cell. Longevity, Vol. 2017. 10.1155/2017/3035184.
    CrossRef  |  Direct Link  |  
  51. Aly, M.S., S.R. Galaly, N. Moustafa, H.M. Mohammed, S.M. Khadrawy and A.M. Mahmoud, 2017. Hesperidin protects against diethylnitrosamine/carbon tetrachloride-induced renal repercussions via up-regulation of Nrf2/HO-1 signaling and attenuation of oxidative stress. J. Applied Pharmaceut. Sci., 7: 7-14.
    CrossRef  |  Direct Link  |  
  52. Al-Rasheed, N.M., N.M. Al-Rasheed, I.H. Hasan, M.A. Al-Amin, H.N. Al-Ajmi, R.A. Mohamad and A.M. Mahmoud, 2017. Simvastatin ameliorates diabetic cardiomyopathy by attenuating oxidative stress and inflammation in rats. J. Oxid. Med. Cell. Longevity. .
    Direct Link  |  
  53. Al-Basher, G., J.S. Ajarem, A.A. Allam and A.M. Mahmoud, 2017. Green tea protects against perinatal nicotine-induced histological, biochemical and hematological alterations in mice offspring. Int. J. Pharmacol., 13: 109-121.
    CrossRef  |  Direct Link  |  
  54. Ajarem, J.S., G. Al-Basher, A.A. Allam and A.M. Mahmoud, 2017. Camellia sinensis prevents perinatal nicotine-induced neurobehavioral alterations, tissue injury and oxidative stress in male and female mice newborns. Oxid. Med. Cell. Longevity. 10.1155/2017/5985219.
    CrossRef  |  Direct Link  |  
  55. Abdel-Rahman, M.M., A.M. Mahmoud, N.A. Bastawy and H.M. Eisa, 2017. Anti-hyperlipidemic and myocardial enhancing effects of berberine in high fat diet/streptozotocin-induced diabetic rats; possible role of adiponectin. Nutr. Food Sci. Int. J., Vol. 2. 10.19080/NFSIJ.2017.02.555580.
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  56. Mahmoud, A.M., H.A. Soliman, A.M. Abd El-Hameed and E.S. Abd El-Rehim, 2016. Wheat germ oil attenuates cyclophosphamide-induced testicular injury in rats. World J. Pharm. Pharmaceut. Sci., 5: 40-52.
    Direct Link  |  
  57. Mahmoud, A.M., 2016. Protective effects of umbelliferone in experimental testicular ischaemia/reperfusion injury in rats. Anat. Physiol., Vol. 6. 10.4172/2161-0940.1000189.
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  58. Mahmoud, A.M. and O.E. Hussein, 2016. Hesperidin as a promising anti-diabetic flavonoid: the underlying molecular mechanism. Int. J. Food Nutr. Sci., 3: 313-314.
    Direct Link  |  
  59. Mahmoud, A.M. and O.E. Hussein, 2016. Flavonoids as potential Wnt/β-catenin signaling modulators for colorectal cancer prevention. Int. J. Food Nutr. Sci., 3: 210-212.
    Direct Link  |  
  60. Mahmoud, A.M. and O.E. Hussein, 2016. Anti-diabetic effect of Naringin: Insights into the molecular mechanism. Diabetes Obes Int. J., Vol. 1. .
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  61. Kamel, E.M., A.M. Mahmoud, S.A. Ahmed and A.M. Lamsabhi, 2016. A phytochemical and computational study on flavonoids isolated from Trifolium resupinatum L. and their novel hepatoprotective activity. Food Funct., 7: 2094-2106.
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  62. Hussein, O.E., M.O. Germoush and A.M. Mahmoud, 2016. Ruta graveolens protects against isoniazid/rifampicin-induced nephrotoxicity through modulation of oxidative stress and inflammation. Global J. Biotechnol. Biomater. Sci., 2: 8-13.
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  63. Hozayen, W.G., A.M. Mahmoud, H.A. Soliman and S.R. Mostafa, 2016. Spirulina versicolor improves insulin sensitivity and attenuates hyperglycemia-mediated oxidative stress in fructose-fed rats. J. Intercult. Ethnopharmacol., 5: 57-64.
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  64. Alqahtani, S. and A.M. Mahmoud, 2016. Gamma-glutamylcysteine ethyl ester protects against cyclophosphamide-induced liver injury and hematologic alterations via upregulation of pparγ and attenuation of oxidative stress, inflammation and apoptosis. Oxid. Med. Cell. Longevity, Vol. 2016. 10.1155/2016/4016209.
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  65. Al-Samhari, M.M., N.M. Al-Rasheed, S. Al-Rejaie, N.M. Al-Rasheed, I.H. Hasan, A.M. Mahmoud and N. Dzimiri, 2016. Possible involvement of the JAK/STAT signaling pathway in N-acetylcysteine-mediated antidepressant-like effects. Exp. Biol. Med., 241: 509-518.
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  66. Al-Rasheed, N.M., N.M. Al-Rasheed, I.H. Hasan, M.A. Al-Amin, H.N. Al-Ajmi and A.M. Mahmoud, 2016. Sitagliptin attenuates cardiomyopathy by modulating the JAK/STAT signaling pathway in experimental diabetic rats. Drug Des. Dev. Ther., 10: 2095-2107.
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  67. Ahmed, O.M., A.M. Mahmoud, S.F.A. Zid and N.Y. Saber, 2016. Silymarin and hydroethanolic extracts of Silybum marianum leaves and fruits attenuate diethylnitrosamine/phenobarbital-induced nephrotoxicity via their antioxidant and anti-inflammatory actions. Am. J. Biochem., 6: 21-29.
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  68. Abdella, E.M., A.M. Mahmoud and A.M. El-Derby, 2016. Brown seaweeds protect against azoxymethane-induced hepatic repercussions through up-regulation of peroxisome proliferator-activated receptor gamma and attenuation of oxidative stress. Pharmaceut. Biol., 54: 2496-2504.
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  69. Abdel-Rahman, M.M., A.M. Mahmoud, N.M. Mostafa, M.E. Saleh and H.M. Eissa, 2016. Sildenafil reduces ischemia/reperfusion testicular injury after torsion/detorsion in rats. J. Applied Pharmaceut. Sci., 6: 135-140.
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  70. Abd El-Twab, S.M., W.G. Hozayen, O.E. Hussein and A.M. Mahmoud, 2016. 18β-Glycyrrhetinic acid protects against methotrexate-induced kidney injury by up-regulating the Nrf2/ARE/HO-1 pathway and endogenous antioxidants. Renal Failure, 38: 1516-1527.
    CrossRef  |  Direct Link  |  
  71. Abd El-Twab, S.M., H.M. Mohamed and A.M. Mahmoud, 2016. Taurine and pioglitazone attenuate diabetes-induced testicular damage by abrogation of oxidative stress and up-regulation of the pituitary-gonadal axis. Can. J. Physiol. Pharmacol., 94: 651-661.
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  72. Abd El-Reheem, E.S., A.M. Mahmoud, A.M. Abd El-Hameed and H.A. Soliman, 2016. Effect of cinnamaldehyde on the toxicity of cyclophosphamide in the testes of rats: Influence of pre- and post-treatment schedule. Nat. Sci., 14: 44-51.
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  73. Toral, M., M. Romero, R. Jimenez, A.M. Mahmoud and E. Barroso et al., 2015. Carnitine palmitoyltransferase-1 up-regulation by PPAR-β/δ prevents lipid-induced endothelial dysfunction. Clin. Sci., 129: 823-837.
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  74. Soliman, H.A., W.G. Hozayen, A.M. Mahmoud, N.A. Fayed and M.A. Abo-Seif, 2015. Significance of the hepatitis C virus core antigen testing as an alternate marker for hepatitis diagnosis in Egyptian patients. Eur. Rev. Med. Pharmacol. Sci., 19: 2240-2245.
  75. Mahmoud, A.M., W.G. Hozayen, H.A. Soliman and S.R. Mostafa, 2015. Enteromorpha flexuosa improves insulin sensitivity and metabolic control in fructose-induced diabetic rats. J. Endocrinol. Diabetes Obes., Vol. 3, No. 2. .
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  76. Mahmoud, A.M., R.R. Ahmed, H.A. Soliman and M. Salah, 2015. Ruta graveolens and its active constituent rutin protect against diethylnitrosamine-induced nephrotoxicity through modulation of oxidative stress. J. Appl. Pharm. Sci., 5: 16-21.
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  77. Mahmoud, A.M., O.M. Ahmed, M.B. Ashour and A. Abdel-Moneim, 2015. In vivo and in vitro antidiabetic effects of citrus flavonoids; a study on the mechanism of action. Int. J. Diabetes Dev. Countries, 35: 250-263.
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  78. Mahmoud, A.M., O.M. Ahmed, M.B. Ashour and A. Abdel-Moneim, 2015. In vivo and in vitro antidiabetic effects of citrus flavonoids; a study on the mechanism of action. Int. J. Diabetes Dev. Countries, (In Press). 10.1007/s13410-014-0268-x.
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  79. Mahmoud, A.M., E.M. Abdella, A.M. El-Derby and E.M. Abdella, 2015. Protective effects of Turbinaria ornata and Padina pavonia against azoxymethane-induced colon carcinogenesis through modulation of PPAR gamma, NF-κB and oxidative stress. Phytother. Res., 29: 737-748.
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  80. Mahmoud, A.M., E.M. Abdella, A.M. El‐Derby and E.M. Abdella, 2015. Protective effects of Turbinaria ornata and Padina pavonia against azoxymethane-induced colon carcinogenesis through modulation of PPAR gamma, NF-κB and oxidative stress. Phytother. Res., (In Press). 10.1002/ptr.5310.
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  81. Mahmoud, A.M., B.M. Morsy, D.S. Abdel-Hady and R.M. Samy, 2015. Prunus armeniaca leaves extract protects against isoniazid and rifampicin induced nephrotoxicity through modulation of oxidative stress and inflammation. Int. J. Food Nutr. Sci., 2: 100-105.
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  82. Mahmoud, A.M., 2015. Flavonoids as ligands for peroxisome proliferator-activated receptor γ. Int. J. Food Nutr. Sci., 2: 98-99.
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  83. Mahmoud, A.M. and H.S. Al Dera, 2015. 18β-Glycyrrhetinic acid exerts protective effects against cyclophosphamide-induced hepatotoxicity: Potential role of PPARγ and Nrf2 upregulation. Genes Nutr., Vol. 10. 10.1007/s12263-015-0491-1.
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  84. Germoush, M.O., H.A. Elgebaly, S. Hassan and A.M. Mahmoud, 2015. Anti-diabetic effects of Padina pavonia in fructose-induced diabetic rats. Aljouf Univ. Sci. Eng. J., 2: 10-16.
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  85. Al-Rasheed, N.M., M.M. Al-Oteibi, R.Z. Al-Manee, S.A. Al-Shareef and N.M. Al-Rasheed et al., 2015. Simvastatin prevents isoproterenol-induced cardiac hypertrophy through modulation of the JAK/STAT pathway. Drug Des. Dev. Ther., 9: 3217-3229.
    CrossRef  |  PubMed  |  Direct Link  |  
  86. Ahmed, R.R., A.M. Mahmoud, M.B. Ashour and A.M. Kamel, 2015. Hesperidin protects against diethylnitrosamine-induced nephrotoxicity through modulation of oxidative stress and inflammation. Natl. J. Physiol. Pharm. Pharmacol., 5: 391-397.
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  87. Ahmed, R.R., A. Mahmoud, O.M. Ahmed, A. Metwalli and H. Ebaid, 2015. Up-regulation of Hsp72 and keratin16 mediates wound healing in streptozotocin diabetic rats. Biol. Res., Vol. 48. 10.1186/s40659-015-0044-5.
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  88. Soliman, A.S., A.M. Mahmoud, Z. Serry and F. Dawood, 2014. Therapeutic effects of low-level laser and reflexology on adhesive capsulitis in elderly type 2 diabetic patients. Asian J. Pharmaceut. Clin. Res., 7: 317-321.
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  89. Osman, A.A., A.M. Mahmoud and A.S. Soliman, 2014. Rapid detection of bovine-specific nucleic acid sequences in cow milk using polymerase chain reaction. Int. J. Nutr. Food Sci., 3: 141-144.
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  90. Morsy, B.M., A.M. Mahmoud, M.I. Zanaty, A. Abdel-Moneim and M.A. Abo-Seif, 2014. Beneficial effects of milk kefir in patients with chronic hepatitis C virus infection. Int. J. Bioassays, 3: 3086-3091.
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  91. Mahmoud, A.M., O.M. Ahmed and S.R. Galaly, 2014. Thymoquinone and curcumin attenuate gentamicin-induced renal oxidative stress, inflammation and apoptosis in rats. EXCLI J., 13: 98-110.
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  92. Mahmoud, A.M., M.O. Germoush, H.A. Elgebaly, K.N.M. Elsayed, S. Hassan, N.M. Mousa and O.E. Hussein, 2014. Anti-diabetic and insulin sensitizing effects of Padina pavonia and Turbenaria ornata in streptozotocin/nicotinamide diabetic rats. Asian J. Pharmaceut. Clin. Res., 7: 74-78.
    Direct Link  |  
  93. Mahmoud, A.M., M.O. Germoush and A.S. Soliman, 2014. Berberine attenuates isoniazid-induced hepatotoxicity by modulating peroxisome proliferator-activated receptor γ, oxidative stress and inflammation. Int. J. Pharmacol., 10: 451-460.
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  94. Mahmoud, A.M., M.O. Germoush and A.S. Soliman, 2014. Ruta graveolens mitigates ammonium chloride-induced hyperammonemia by modulating antioxidant status and pro-inflammatory cytokines. Life Sci. J., 11: 269-275.
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  95. Mahmoud, A.M., M. Toral, M. Romero, M. Gomez-Guzman and M. Sanchez et al., 2014. Protective effects of Peroxisome Proliferator-Activated Receptor (PPAR)-β activation on lipid-induced endothelial dysfunction via carnitine palmitoyl transferase-1 upregulation. Heart, Vol. 100. 10.1136/heartjnl-2014-306916.26.
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  96. Mahmoud, A.M., A. El-Derby, K.N. Elsayed and E. Abdella, 2014. Brown seaweeds ameliorate renal alterations in mice treated with the carcinogen azoxymethane. Int. J. Pharm. Pharmaceut. Sci., 6: 365-369.
    Direct Link  |  
  97. Mahmoud, A.M., 2014. Hesperidin protects against cyclophosphamide-induced hepatotoxicity by upregulation of PPARγ and abrogation of oxidative stress and inflammation. Can. J. Physiol. Pharmacol., 92: 717-724.
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  98. Germoush, M.O. and A.M. Mahmoud, 2014. Berberine mitigates cyclophosphamide-induced hepatotoxicity by modulating antioxidant status and inflammatory cytokines. J. Cancer Res. Clin. Oncol., 140: 1103-1109.
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  99. Galaly, S.R., O.M. Ahmed and A.M. Mahmoud, 2014. Thymoquinone and curcumin prevent gentamicin-induced liver injury by attenuating oxidative stress, inflammation and apoptosis. J. Physiol. Pharmacol., 65: 823-832.
    PubMed  |  Direct Link  |  
  100. Ahmed, O.M., B.M. Ashour, H.E. Fahim, A.M. Mahmoud and N.A. Ahmed, 2014. Preventive effect of Spirulina versicolor and Enteromorpha flexuosa ethanolic extracts against diethylnitrosamine/benzo(a)pyrene-induced hapatocarcinogencity in rats. J. Int. Acad. Res. Multidisciplin., 2: 633-650.
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  101. Abouzid, S.F., O.M. Ahmed, R.R. Ahmed, A.M. Mahmoud, E. Abdella and M.B. Ashour, 2014. Antihyperglycemic effect of crude extracts of some Egyptian plants and algae. J. Med. Food, 17: 400-406.
    CrossRef  |  Direct Link  |  
  102. Mahmoud, A.M., O.M. Ahmed, A. Abdel-Moneim and M.B. Ashour, 2013. Upregulation of pparγ mediates the antidiabetic effects of citrus flavonoids in type 2 diabetic rats. Int. J. Bioassays, 2: 756-761.
    Direct Link  |  
  103. Mahmoud, A.M., O.E. Hussein and S.A. Ramadan, 2013. Amelioration of cyclophosphamide-induced hepatotoxicity by the brown seaweed Turbenaria ornata. Studies, 1: 9-17.
    Direct Link  |  
  104. Mahmoud, A.M., 2013. Hematological alterations in diabetic rats: Role of adipocytokines and effect of citrus flavonoids. EXCLI J., 12: 647-657.
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  105. Mahmoud, A.M. and A.S. Soliman, 2013. Rutin attenuates hyperlipidemia and cardiac oxidative stress in diabetic rats. Egypt. J. Med. Sci., 34: 287-302.
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  106. Ebaid, H., O.M. Ahmed, A.M. Mahmoud and R.R. Ahmed, 2013. Limiting prolonged inflammation during proliferation and remodeling phases of wound healing in streptozotocin-induced diabetic rats supplemented with camel undenatured whey protein. BMC Immunol., Vol. 14. 10.1186/1471-2172-14-31.
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  107. Abou Riag, N.B.S., A.M. Mahmoud and S.A. Ramadan, 2013. Sildenafil alleviates insulin sensitivity via attenuating oxidative stress and proinflammatory cytokines in diabetic rats. Int. J. Pharm. Bio. Sci., 4: 427-436.
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  108. Abdella, E.M., R.R. Ahmed, M.B. Ashour, O.M. Ahmed, S.F. Abu Zid and A.M. Mahmoud, 2013. Bioinformatics analysis of functional genes and proteins for the diagnosis of obesity-induced type 2 diabetes. Int. J. Fundamental Applied Sci., 2: 23-28.
  109. Abdel-Moneim, A., B.M. Morsy, A.M. Mahmoud, M.A. Abousief and M. Zanaty, 2013. Benificial therapeutic effects of Nigella sativa and Ginger officinalle in HCV patients in Egypt. EXCLI J., 12: 943-955.
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  110. Mahmoud, A.M., O.M. Ahmed, M.B. Ashour and A. Abdel-Moneim, 2012. Hesperidin and naringin attenuate hyperglycemia-mediated oxidative stress and proinflammatory cytokine production in high fat fed/strptozotocin-induced type 2 diabetic rats. Diabetes Complications, 26: 483-490.
  111. Mahmoud, A.M., 2012. Influence of rutin on biochemical alterations in hyperammonemia in rats. Exp. Toxicol. Pathol., 64: 783-789.
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  112. Ahmed, O.M., A.M. Mahmoud, A. Abdel-Moneim and M.B. Ashour, 2012. Antidiabetic effects of hesperidin and naringin in type 2 diabetic rats. Diabetologia Croatica, 41: 53-67.
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  113. Ahmed, O.M., A. Afifi, T.M. Ali, S.A. Ramadan and A.M. Mahmoud, 2012. Ameliorative effects of sildenafil in acetic acid-induced chronic colitis in rats. Life Sci. J., 9: 354-361.
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  114. Ahmed, O.M., A.M. Mahmoud, A. Abdel-Moneim and M.B. Ashour, 2011. Antihyperglycemic and antihyperlipidemic effects of hesperidin and naringin in high fat diet/streptozotocin type 2 diabetic rats. Life Sci., 8: 91-101.
  115. Abdel-Moneim, A., M.B. Ashour, A.M. Mahmoud and O.M. Ahmed, 2011. Insulin sensitizing effects of hesperidin and naringin in experimental model of induced type 2 diabetes in rats: Focus on tumor necrosis factor-alpha and Resistin. Nat. Sci., 9: 134-141.
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  116. Ahmed, O.M., A.A. Moneim, I.A. Yazid and A.M. Mahmoud, 2010. Antihyperglycemic, antihyperlipidemic and antioxidant effects and the probable mechanisms of action of Ruta graveolens and rutin in Nicotinamide/streptozotocin diabetic albino rats. Diabetol. Croatica, 39: 15-35.
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