Dr. Mohamed Mohamed Sayed-Ahmed
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Dr. Mohamed Mohamed Sayed-Ahmed

Professor
National Cancer Institute, Egypt

Highest Degree
Ph.D. in Pharmacology and Experimental Oncology from Duke University Medical Center, USA

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Area of Interest:

Pharmacology and Toxicology
100%
Gene Expression
62%
Biological Markers
90%
Anticancer Drug
75%
Metabolism
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
0
Abstracts
0

Selected Publications

  1. Lam, T., Z. Chen, M.M. Sayed-Ahmed, A. Krassioukov and A.A. Al-Yahya, 2013. Potential role of oxidative stress on the prescription of rehabilitation interventions in spinal cord injury. Spinal Cord, 51: 656-662.
    CrossRef  |  
  2. El-Azab, A.S., S.G. Abdel-Hamide, M.M. Sayed-Ahmed, G.S. Hassan and T.M. El-Hadiyah et al., 2013. Novel 4(3H)-quinazolinone analogs: Synthesis and anticonvulsant activity. Med. Chem. Res., 22: 2815-2827.
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  3. Al-Shabanah, O.A., M.M. Hafez, Z.K. Hassan, M.M. Sayed-Ahmed, W.N. Abozeed, S.S. Al-Rejaie and A.A. Alsheikh, 2013. Human papillomavirus genotyping and integration in ovarian cancer Saudi patients. Virol. J., Vol. 10. 10.1186/1743-422X-10-343.
    CrossRef  |  
  4. Al-Rejaie, S.S., A.M. Aleisa, M.M. Sayed-Ahmed, O.A. Al-Shabanah and H.M. Abuohashish et al., 2013. Protective effect of rutin on the antioxidant genes expression in hypercholestrolemic male Westar rat. BMC Complementary Altern. Med., Vol. 13. 10.1186/1472-6882-13-136.
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  5. Sayed-Ahmed, M.M., M.M. Hafez, M.L. Aldelemy, A.M. Aleisa and S.S. Al-Rejaie et al., 2012. Downregulation of oxidative and nitrosative apoptotic signaling by L-carnitine in Ifosfamide-induced fanconi syndrome rat model. Oxidative Med. Cell. Longevity, Vol. 2012. 10.1155/2012/696704.
    CrossRef  |  Direct Link  |  
  6. Sayed-Ahmed, M.M., M.M. Hafez, A.A. Al-Shabanah, S.S. Al-Rejaie and A.M. Aleisa et al., 2012. Increased expression of biological markers as potential therapeutic targets in Saudi women with triple-negative breast cancer. Tumori, 99: 557-566.
    CrossRef  |  Direct Link  |  
  7. Sayed-Ahmed, M.M., M.L. Aldelemy, M.M. Hafez and O.A. Al-Shabanah, 2012. Inhibition of gene expression of organic cation/carnitine transporter and antioxidant enzymes in oxazaphosphorines-induced acute cardiomyopathic rat models. Oxidative Med. Cell. Longevity, Vol. 2012. 10.1155/2012/452902.
    CrossRef  |  
  8. Hafez, M.M., Z.K. Hassan, A.R. Zekri, A.A. Gaber, S.S. Al-Rejaie, M.M. Sayed-Ahmed and O.A. Al-Shabanah, 2012. MicroRNAs and metastasis-related gene expression in egyptian breast cancer patients. Asian Pac. J. Cancer Prev., 13: 591-598.
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  9. Al-Shabanah, O.A., A.M. Aleisa, M.M. Hafez, S.S. Al-Rejaie and A.A. Al-Yahya et al., 2012. Desferrioxamine attenuates doxorubicin-induced acute cardiotoxicity through TGF-β/Smad p53 pathway in rat model. Oxidative Med. Cell. Longevity,. 10.1155/2012/619185.
    CrossRef  |  
  10. Sayed-Ahmed, M.M., 2011. L-carnitine attenuates ifosfamide-induced carnitine deficiency and decreased intramitochondrial CoA-SH in rat kidney tissues. J. Nephrol., 24: 490-498.
    CrossRef  |  
  11. Nagi, M.N., O.A. Al-Shabanah, M.M. Hafez and M.M. Sayed-Ahmed, 2011. Thymoquinone supplementation attenuates cyclophosphamide-induced cardiotoxicity in rats. J. Biochem. Mol. Toxicol., 25: 135-142.
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  12. El-Subbagh, H.I., G.S. Hassan, A.S. El-Azab, A.A. Abdel-Aziz and A.A. Kadi et al., 2011. Synthesis and anticonvulsant activity of some new thiazolo[3,2-a][1,3]diazepine, benzo[d]thiazolo[5,2-a][12,6]diazepine and benzo[d]oxazolo[5,2-a][12,6]diazepine analogues. Eur. J. Med. Chem., 46: 5567-5572.
    Direct Link  |  
  13. Alhaider, A.A., H.M. Korashy, M.M. Sayed-Ahmed, M. Mobark, H. Kfoury and M.A. Mansour, 2011. Metformin attenuates streptozotocin-induced diabetic nephropathy in rats through modulation of oxidative stress genes expression. Chemico-Biol. Interact., 192: 233-242.
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  14. Sayed-Ahmed, M.M., O.A. Al-Shabanah, M.M. Hafez, A.M. Aleisa and S.S. Al-Rejaie, 2010. Inhibition of gene expression of heart fatty acid binding protein and organic cation/carnitine transporter in doxorubicin cardiomyopathic rat model. Eur. J. Pharmacol., 640: 143-149.
    CrossRef  |  Direct Link  |  
  15. Sayed-Ahmed, M.M., A.Q. Darweesh and A.J. Fatani, 2010. Carnitine deficiency and oxidative stress provoke cardiotoxicity in an ifosfamide-induced Fanconi Syndrome rat model. Oxidative Med. Cell. Longevity, 3: 266-274.
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  16. Sayed-Ahmed, M.M., A.M. Aleisa, S.S. Al-Rejaie, A.A. Al-Yahya, O.A. Al-Shabanah, M.M. Hafez and M.N. Nagi, 2010. Thymoquinone attenuates diethylnitrosamine induction of hepatic carcinogenesis through antioxidant signaling. Oxidative Med. Cell. Longevity, 3: 254-261.
    CrossRef  |  PubMed  |  Direct Link  |  
  17. Sayed-Ahmed, M.M., 2010. Role of carnitine in cancer chemotherapy-induced multiple organ toxicity. Saudi Pharm. J., 18: 195-206.
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  18. Sayed-Ahmed, M.M., 2010. Progression of cyclophosphamide-induced acute renal metabolic damage in carnitine-depleted rat model. Clin. Exp. Nephrol., 14: 418-426.
    CrossRef  |  
  19. Nagi, M.N., H.A. Almakki, M.M. Sayed-Ahmed and A.M. Al-Bekairi, 2010. Thymoquinone supplementation reverses acetaminophen-induced oxidative stress, nitric oxide production and energy decline in mice liver. Food Chem. Toxicol., 48: 2361-2365.
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  20. Fatani, A.G., A.Q. Darweesh, L. Rizwan, A.M. Aleisa, O.A. Al-Shabanah and M.M. Sayed-Ahmed, 2010. Carnitine deficiency aggravates cyclophosphamide-induced cardiotoxicity in rats. Chemotherapy, 56: 71-81.
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  21. El-Azab, A.S., M.A. Al-Omar, A.A. Abdel-Aziz, N.I. Abdel-Aziz and M.A. El-Sayed et al., 2010. Design, synthesis and biological evaluation of novel quinazoline derivatives as potential antitumor agents: Molecular docking study. Eur. J. Med. Chem., 45: 4188-4198.
    PubMed  |  
  22. Al-Shabanah, O.A., M.M. Hafez, M.M. Al-Harbi, Z.K. Hassan, S.S. Al-Rejaie, Y.A. Asiri and M.M. Sayed-Ahmed, 2010. Doxorubicin toxicity can be ameliorated during antioxidant L-carnitine supplementation. Oxid. Med. Cell. Longev., 3: 428-433.
    CrossRef  |  PubMed  |  Direct Link  |  
  23. Al-Shabanah, O.A., A.M. Aleisa, A.A. Al-Yahya, S.S. Al-Rejaie, S.A. Bakheet, A.G. Fatani and M.M. Sayed-Ahmed, 2010. Increased urinary losses of carnitine and decreased intramitochondrial coenzyme a in gentamicin-induced acute renal failure in rats. Nephrol. Dial. Trans., 25: 69-76.
    CrossRef  |  Direct Link  |  
  24. Abdel Baky, N.A., Z.F. Zaidi, A.J. Fatani, M.M. Sayed-Ahmed and H. Yaqub, 2010. Nitric oxide pros and cons: The role of L-arginine, a nitric oxide precursor and idebenone, a coenzyme-Q analogue in ameliorating cerebral hypoxia in rat. Brain Res. Bull., 83: 49-56.
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  25. Al-Rejaie, S.S., A.M. Aleisa, A.A. Al-Yahya, S.A. Bakheet and A. Alsheikh et al., 2009. Progression of diethylnitrosamine-induced hepatic carcinogenesis in carnitine-depleted rats. World J. Gastroenterol., 15: 1373-1380.
    CrossRef  |  PubMed  |  
  26. Sayed-Ahmed, M.M., 2007. Multidrug resistance to cancer chemotherapy: Genes involved and blockers. Saudi Pharm. J., 15: 161-175.
  27. Sayed-Ahmed, M.M., 2007. Increased serum and cardiac acyl-carnitine/free carnitine ratio during development of doxorubicin-induced cardiotoxicity. Saudi Pharm. J., 15: 120-126.
  28. Sayed-Ahmed, M.M. and M.N. Nagi, 2007. Thymoquinone supplementation prevents the development of gentamicin-induced acute renal toxicity in rats. Clin. Exp. Pharmacol. Physiol., 34: 399-405.
    CrossRef  |  PubMed  |  Direct Link  |  
  29. Kamel, M.W., S.A. Salama, S. Saleh, A.M.M.Osman, M.S. Ahmed and A. Al-Hendy, 2007. Reversal of doxorubicin resistance by adenovirus-mediated transfer of cyclooxygenase-2 antisense in multidrug-resistant MCF-7 cells. Cancer Therapy, 5: 1-10.
  30. Aleisa, A.M., A.A. Al-Majed, A.A. Al-Yahya, S.S. Al-Rejaie, S.A. Bakheet, O.A. Al-Shabanah and M.M. Sayed-Ahmed, 2007. Reversal of cisplatin-induced carnitine deficiency and energy starvation by propionyl-L-carnitine in rat kidney tissues. Clin. Exp. Pharmacol. Physiol., 34: 1252-1259.
    CrossRef  |  PubMed  |  Direct Link  |  
  31. Al-Majed, A.A., M.M. Sayed-Ahmed, F.A. Al-Omar, A.A. Al-Yahya, A.M. Aleisa and O.A. Al-Shabanah, 2006. Carnitine esters prevent oxidative stress damage and energy depletion following transient forebrain ischaemia in the rat hippocampus. Clin. Exp. Pharmacol. Physiol., 33: 725-733.
    Direct Link  |  
  32. Al-Majed, A.A., M.M. Sayed-Ahmed, A.A. Al-Yahya, A.M. Aleisa, S.S. Al-Rejaie and O.A. Al-Shabanah, 2006. Propionyl-L-carnitine prevents the progression of cisplatin-induced cardiomyopathy in a carnitine-depleted rat model. Pharmacol. Res., 53: 278-286.
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  33. Sayed-Ahmed, M.M. and A.M. Mohamed, 2005. Contribution of nitric oxide and epidermal growth factor receptor in antimetastatic potenial of paclitaxel in human liver cancer cells (Heb G2). J. Egypt. Nat. Cancer Inst., 17: 35-41.
  34. El-Demerdash, E., A.S. Awad, R.M. Taha, A.M. El-Hady and M.M. Sayed-Ahmed, 2005. Probucol attenuates oxidative stress and energy decline in isoproterenol-induced heart failure in rat. Pharmacol. Res., 51: 311-318.
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  35. Sayed-Ahmed, M.M., M. Eissa, S. Kenawy, N. Mostafa, M. Calvani and A.M. Osman, 2004. Progression of cisplatin-induced nephrotoxicity in a carnitine-depleted rat model. Chemotherapy, 50: 162-170.
    CrossRef  |  Direct Link  |  
  36. Sayed-Ahmed, M.M., H.H. Mansour, O.A. Gharib and H.F.Hafez, 2004. Acetyl-L-carnitine modulates bleomycin-induced oxidative stress and energy depletion in lung tissues. J. Egypt. Nat. Canc. Inst., 16: 237-243.
    PubMed  |  
  37. El-Demerdash, E., A.A. Ali, M.M. Sayed-Ahmed and A.M. Osman, 2003. New aspects in probucol cardioprotection against doxorubicin-induced cardiotoxicity. Cancer Chemother. Pharmacol., 52: 411-416.
    CrossRef  |  
  38. Arafa, H.M.M. and M.M. Sayed-Ahmed, 2003. Protective role of carnitine esters against Alcohol-induced gastric lesions in rats. Pharmacol. Res., 48: 285-290.
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  39. Sayed-Ahmed, M.M., S.A. Shouman and L.A. Ramadan, 2002. Contribution of nitric oxide in doxorubicin-related cytotoxicity in murine tumour model. J. Egypt. Nat. Cancer Inst., 14: 111-116.
  40. Sayed-Ahmed, M.M., T.M. Salman, H.E. Gaballah, S.A. Abou El-Naga, R. Nicolai and M. Calvani, 2001. Propionyl-l-carnitine as protector against adriamycin-induced cardiomyopathy. Pharmacol. Res., 43: 513-520.
    CrossRef  |  
  41. Sayed-Ahmed, M.M., M.M. Khattab, M.Z. Gad and N. Mostafa, 2001. L-carnitine prevents the progression of atherosclerotic lesions in hypercholesterolaemic rabbits. Pharmacol. Res., 44: 235-242.
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  42. Sayed-Ahmed, M.M., M.M. Khattab, M.Z. Gad and A.M. Osman, 2001. Increased plasma endothelin-1 and cardiac nitric oxide during doxorubicin-induced cardiomyopathy. Pharmacol. Toxicol., 89: 140-144.
    Direct Link  |  
  43. Ramadan, L.A., S.A. Shouman, M.M. Sayed-Ahmed and O.H. El-Habit, 2001. Modulation of radiation-induced organs toxicity by cremophor-el in experimental animals. Pharmacol. Res., 43: 185-191.
    CrossRef  |  
  44. Ramadan, L.A., O. El-Habit, H. Arafa and M.M. Sayed-Ahmed, 2001. Effect of cremophor-El on cisplatin induced organs toxicity in normal rats. J. Egypt. Nat. Cancer Inst., 13: 11-17.
  45. Sayed-Ahmed, M.M., S.A. Shouman, B.M. Rezk, M.H. Khalifa, A.M. Osman and M.M. El-Merzabani, 2000. Propionyl-L-carnitine as potential protective agent against adriamycin-induced impairment of fatty acid β-oxidation in isolated heart mitochondria. Pharmacol. Res., 41: 143-150.
  46. Sayed-Ahmed, M.M., A.M. Kishk, S. Soloma and S. Abdel-Aleem, 2000. Protection by L-carnitine against the inhibition of gene expression of heart fatty acid binding protein by chronic administration of doxorubicin. J. Egypt. Nat. Cancer Inst., 12: 275-281.
  47. Salman, T.M. and M.M. Sayed-Ahmed, 2000. Effects of trichloroactate, water chlorination by-product, on liver peroxisomes and antioxidant status in rats and mice. Sci. J. Az. Med. Fac. (Girls), 21: 631-648.
  48. Osman, A.M., M.A. Mohamed, A.A. Abdel-Wahab and M.S. Ahmed, 2000. Modulation by verapamil of doxorubicin induced expression of multidrug resistance gene (mdr-1/P-glycoprotein) in murine tumour cells. J. Egypt. Nat. Cancer Inst., 12: 221-227.
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  49. Osman, A.M., H. Gaballa, N.H. Mohamed, N.M. Ali., M.S. Ahmed and H.M. Arafa, 2000. Plasma endothelin (ET-1) as a marker for doxorubicin-induced cardiotoxicity in egyptian patients. J. Egypt Soc. Toxicol., 23: 59-64.
  50. Sayed-Ahmed, M.M., S. Sharawy, S.A. Shouman and A.M. Osman, 1999. Reversal of doxorubicin-induced cardiac metabolic damage by l-carnitine. Pharmacol. Res., 33: 289-295.
  51. Sayed-Ahmed, M.M., M. Khattab, A. Khalifa, M. El-Khabany and A.M. Osman, 1999. Potenial promise of using L-carnitine and Coenzyme Q10 as protective agents against Cisplatin-induced nephrotoxicity. J. Egypt. National Cancer Inst., 11: 167-173.
  52. Hanafy, M., S.M.M. Ahmed and A.M. Osman, 1999. The protective effect of methimazole against cisplatin-induced chromosomal abberrations. Sci. J. Az. Med. Fac.(Girls), 20: 637-645.
  53. Abidli, N., M.M. Sayed-Ahmed, S.M. El-Gerzawy, M.M. El-Didi, C. Benlatreche, M.M. El-Merzabani and A.M. Osman, 1999. Verapamil enhancement of the cytotoxic and cell cycle perturbation of doxorubicin in Ehrlich ascites carcinoma cells in vivo. J. Egypt. National Cancer Inst., 10: 433-438.
  54. Abdel-Aleem, S., M.M. El-Merzabani, M. Sayed-Ahmed, D.A. Taylor and J.E. Lowe, 1997. Acute and chronic effects of adriamycin on fatty acid oxidation in isolated cardiac myocytes. J. Mol. Cell. Cardiol., 29: 789-797.
    CrossRef  |  Direct Link  |  
  55. Abdel-Aleem, S., M.A. Nada, M. Sayed-Ahmed, S.C. Hendrickson, J. St Louis, H.P. Walthall and J.E. Lowe, 1996. Regulation of fatty acid oxidation by acetyl-CoA generated from glucose utilization in isolated myocytes. J. Mol. Cell. Cardiol., 28: 825-833.
    CrossRef  |  
  56. Abdel-Aleem, S., M. Sayed-Ahmed, M.A. Nada, S.C. Hendrickson, J. St Louis and J.E. Lowe, 1995. Stimulation of non-oxidative glucose utilization by L-carnitine in isolated myocytes. J. Mol. Cell. Cardiol., 27: 2465-2472.
    CrossRef  |  
  57. Shouman, S.A., M.M. Sayed-Ahmed and M.M. El-Merzabani, 1994. Potentiation of the chemotherapeutic effect of methotrexate by hyperthermia in experimental animal tumour model. J. Egypt. Nat. Cancer Inst., 6: 868-876.
  58. Abdel-Aleem, S., S. Sharwi, M. Badr, M. Sayed-Ahmed, M.P. Anstadt and J.E. Lowe, 1994. Reduced induction of carbohydrate utilization by inhibition of fatty acid oxidation in myocytes from diabetic animals. Horm. Metab. Res., 27: 104-106.
    Direct Link  |  
  59. Osman, A.M., M.M. Ahmed, M.T. Khyyal and M.M. El-Merzabani, 1993. Hyperthermic potentiation of cisplatin cytotoxicity on solid Ehrlich carcinoma. Tumori, 79: 268-272.
    PubMed  |  Direct Link  |