Dr. Aloke Chinyere
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Dr. Aloke Chinyere

Lecturer I
Department of Medical Biochemistry, Faculty of Basic Medical Sciences, Alex Ekwueme Federal University, Ndufu-Alike Ikwo, Abakaliki, Ebonyi State, Nigeria


Highest Degree
Ph.D. in Medical Biochemistry from Ebonyi State University, Abakaliki, Nigeria

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Area of Interest:

Chemistry
100%
Medical Biochemistry
62%
Alternative Medicine
90%
Applied Sciences
75%
Toxicology
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
44
Abstracts
6

Selected Publications

  1. Padi, N., B.O. Akumadu, O. Faerch, C. Aloke, V. Meyer and I. Achilonu, 2021. Engineering a pseudo-26-kDa Schistosoma glutathione transferase from bovis/haematobium for structure, kinetics, and ligandin studies. Biomolecules, Vol. 11. 10.3390/biom11121844.
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  2. Orji, O.U., J.N. Awoke, P.M. Aja, C. Aloke and O.D. Obasi et al., 2021. Halotolerant and metalotolerant bacteria strains with heavy metals biorestoration possibilities isolated from uburu salt lake, Southeastern, Nigeria. Heliyon, Vol. 7. 10.1016/j.heliyon.2021.e07512.
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  3. Orji, O.U., J.N. Awoke, C. Aloke, O.D. Obasi, B. Oke, M. Njoku and N.N. Ezeani, 2021. Toxic metals bioremediation potentials of Paenibacillus sp. strain SEM1 and Morganella sp. strain WEM7 isolated from Enyigba Pb–Zn mining site, Ebonyi State Nigeria. Biorem. J., 25: 285-296.
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  4. Okoro, C.O., C. Aloke, U.A. Ibiam, Obasi, N.A. and O.U. Orji et al., 2021. Studies on ethanol extracts of Olax subscorpioidea against carbon tetrachloride-induced hepatotoxicity in rats. Pak. J. Biol. Sci., 24: 724-732.
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  5. Ogbu, P.N., L.U.S. Ezeanyika, V.N.E. Ogugua, I.M. Ogbu, C. Aloke and G.N. Ony, 2021. Sphenostylis stenocarpa seed extract attenuates dyslipidemia in testosterone propionate-induced benign prostatic hyperplasia in rats. Pak. J. Biol. Sci., 24: 151-157.
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  6. Obasi, N.A., C. Aloke, S.E. Obasi, C.O. Egwu, A.C. Famurewa and P.N. Ogbu, 2021. Protective effects of Dialium guineense pulp on aspirin-induced gastric mucosal injury in albino rats. J. Appl. Biomed., 19: 170-178.
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  7. Emelike, C.U., U.S.B. Anyaehie, E.E. Iyare, C.A. Obike and C. Aloke et al., 2021. Chemical composition and evaluation of methanol leaf extract of combretum dolichopetalum on body weights and haematological indices of phenylhydrazine induced-anaemic rats. Toxicol. Int., 28: 135-144.
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  8. Aloke, C., U.A. Ibiam, O.U. Orji, E.I. Ugwuja, N.N. Ezeani, P.M. Aja and N.A. Obasi, 2021. Anti-arthritic potential of ethanol and aqueous extracts of stem bark of Cleistopholis patens on complete Freund's adjuvant-induced rheumatoid arthritis in rats. J. Ayurveda Integr. Med., 12: 28-34.
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  9. Aloke, C., N. Nwachukwu, N.A. Obasi, C.U. Emelike and P.A. Amu et al., 2021. Antihyperglycemic, antihyperlipidemic and hepatoprotective effects of Ficus ottoniifolia (Miq.) Miq. supplementation in alloxan-induced diabetic rats. Avicenna J. Phytomed., 11: 428-435.
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  10. Aloke, C., C.U. Emelike, N.A. Obasi, P.N. Ogbu and C.O. Edeogu et al., 2021. HPLC profiling and studies on Copaifera salikounda methanol leaf extract on phenylhydrazine-induced hematotoxicity and oxidative stress in rats. Arabian J. Chem., Vol. 14. 10.1016/j.arabjc.2021.103428.
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  11. Aloke, C., E.S. Igwe, N.A. Obasi, P.A. Amu and E.C. Ogbonnia, 2021. Anti-diabetic effect of ethanol extract of Copaifera salikounda (Heckel) against alloxan-induced diabetes in rats. Slovenian Vet. Res., 58: 63-75.
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  12. Orji, O.U., J.N. Awoke, C. Harbor, I.O. Igwenyi, O.D. Obasi, N.N. Ezeani and C. Aloke, 2020. Ethanol leaf extract of Psychotria microphylla rich in quercetin restores heavy metal induced redox imbalance in rats. Heliyon, Vol. 6. 10.1016/j.heliyon.2020.e04999.
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  13. Obasi,N.A., S.E. Obasi, E. Nweze, S.O. Amadi, C. Aloke and G.O. Aloh, 2020. Metal pollution and human health risk assessment of soils and edible plants in farmlands around Enyigba lead-zinc mining site, Ebonyi State, Nigeria. Environ. Monit. Assess., 10.1007/s10661-020-08280-8.
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  14. Obasi, N.A., C. Aloke, S.E. Obasi, C.A. Famurewa, P.N. Ogbu and G.N. Onyeji, 2020. Elemental composition and associated health risk in honey obtained from apiary farms in Southeast Nigeria. J. Food Prot., 10.4315/JFP-20-072.
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  15. Awoke, J.N., O.U. Orji, P.M. Aja, N.N. Ezeani, C. Aloke and O.D. Obasi, 2020. Ethanol leaf extract of Ruspolia hypocrateriformis abrogated hepatic redox imbalance and oxidative damage induced by heavy metal toxicity in rats. Arabian J. Chem., 13: 8133-8145.
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  16. Ezeani, N.N., U.A. Ibiam, O.U. Orji, I.O. Igwenyi, C. Aloke, E. Alum, P.M. Aja and O.P.C. Ugwu, 2019. Effects of aqueous and ethanol root extracts of olax subscopioidea on inflammatory parameters in complete freund’s adjuvant-collagen type II induced arthritic albino rats. J. Pharmacogn, 11: 16-25.
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  17. Chinyere, A., E.U. Ifeanyi, N.O. Patience, I.U. Emmanuel, F.O. Onyebuchi and O.O. Ikechukwu, 2019. Comparativ e assessment of heavy metals in drinking water sources from enyigba community in abakaliki Local government area, Ebonyi State, Nigeria. Afr. J. Environ. Sci. Technol., 13: 149-154.
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  18. Aloke, C., U.A. Ibiam, O.U. Orji, E.I. Ugwuja, N.N. Ezeani, P.M. Aja and N.A. Obasi, 2019. Anti-arthritic potentials of ethanol and aqueous extracts of stem bark of Cleistopholis patens on complete Freund's adjuvant-induced rheumatoid arthritis in rats. J. Ayurveda Integr. Med., 10.1016/j.jaim.2018.12.009.
    CrossRef  |  Direct Link  |  
  19. Aloke, C., U.A. Ibiam, N.A. Obasi, O.U. Orji, N.N. Ezeani, P.M. Aja, E.U. Alum and J.C. Mordi, 2019. Effect of ethanol and aqueous extracts of seed pod of Copaifera salikounda (Heckel) on complete Freund's adjuvant‐induced rheumatoid arthritis in rats. J. Food Biochem., Vol. 7. 10.1111/jfbc.12912.
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  20. Aloke, C., I.I. Ezeigbo, I.C. Ohanenye, C.C. Udenigwe, C. Jacob and C.E.C.C. Ejike, 2019. A small green red-ox carries a bright medical future for sub-saharan Africa. Curr. Pharmacol. Rep., 5: 245-254.
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  21. Famurewa, A.C., P.M. Aja, O.E. Nwankwo, J.N. Awoke, E.K. Maduagwuna and C. Aloke, 2018. Moringa oleifera seed oil or virgin coconut oil supplementation abrogates cerebral neurotoxicity induced by antineoplastic agent methotrexate by suppression of oxidative stress and neuro‐inflammation in rats. J. Food Biochem., 10.1111/jfbc.12748.
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  22. Offor, C.E., U.E. Uzuegbu, A.O. Opajobi, C. Aloke, N. Edwin, P.C.U. Okechukwu and U.T. Nwafor, 2017. Proximate composition and sugar content of Artocarpus heterophyllus Pulps. Int. Digital Organi. Sci. Res. J. Sci. Res., 2: 66-75.
  23. Offor, C.E., P.N. Abara, P.C.U. Okechukwu, E.U. Ekpono, C. Aloke and C.P. Eneh, 2017. Vitamin and mineral composition of Annona muricata., Sci. Res. J. Sci. Res., 2: 76-82.
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  24. Offor, C.E., C. Aloke, P.C.U. Okechukwu, E.U. Ekpono, C.S. Nwobasi and E.E. Egbeji, 2017. Phytochemical and proximate compositions ofartocarpus heterophyllus leaves. IDOSR J. Applied Sci., 2: 123-130.
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  25. Offor, C.E., C. Aloke, M.C. Ominyi, N. Edwin and U.P.C. Okechukwu et al., 2017. Evaluation of anti-diabetic effect of ethanol leaf-extract of Pterocarpus santalinoides in alloxan-induced diabetic albino rats. IDOSR J. Applied Sci., 2: 114-122.
  26. Obasi, N.A., S.E. Obasi, S.O. Elom, K.M. Kalu and C. Aloke et al., 2017. Health risk assessment of heavy metals in ameri lead-zinc mining community via consumption of cassava (Manihot esculenta Cruz) In Ikwo L.G.A., Ebonyi State, Nigeria. Am. Eur. J. Sustainable Agric., 11: 22-30.
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  27. Nwobasi,. C.S., E.U. Alum, S.M.C. Udeh, N. Edwin, O.F. Orinya, Abara, P.N. and C. Aloke, 2017. Mineral and proximate compositions of Nauclae latifolia root bark from abakaliki, ebonyi state. Int. J. Biol. Pharm. Allied Sci., 6: 375-382.
  28. Aja, P.M., C. Aloke, U.M.C. Sylvester, O.F. Orinya, E.U. Alum, N. Edwin and U.P.C. Okechukwu, 2017. 2017 Mineral and proximate composition of Senna occidentalis leaves. Int. J. Biol. Pharm. Allied Sci., 6: 363-374.
  29. Orji, O.U., U.A. Ibiam, P.M. Aja, U. Okechukwu and P.C. Uraku, 2016. Evaluation of the phytochemical and nutritional profiles of Cnidoscolus aconitifolius leaf collected in abakaliki South East Nigeria. World J. Med. Sci., 13: 213-217.
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  30. Orji, O.U., U.A. Ibiam, P.M. Aja, O.D. Obasi and N. Ezeani et al., 2016. Effect of ethanol extract of Ruspolia hypocrateriformis leaf on haematological parameters in lead poisoned albino rats. World J. Med. Sci., 13 : 225-235.
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  31. Orji, O.U., U.A. Ibiam, C. Aloke, J. Awoke and P.M. Aja et al., 2016. Biochemical assessment of ethanol leaf extract of cnidoscolus aconitifolius on liver intergrity of albino rat treated with lead. Global J. Pharmacol., 10: 108-113.
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  32. Ogah, O., C. Aloke, O.O. Ugwu, M.E. Ogbashi, I. John, A.O. Oko and S.C. Onuoha, 2016. Effects of Annona muricata on total protein, albumin, globulin and body weight in paracetamol overdose-induced liver damage in albino rats. IOSR J. Environ. Sci. Toxicol. Food Technol., 10: 18-22.
  33. Ugwuja, E.I., N.C. Ugwu, V.U. Muoneke, C. Aloke, J.N. Idenyi and H.U. Chukwu, 2015. Plasma levels of copper, iron and zinc in healthy primary school children from rural communities of Ebonyi State, South Eastern Nigeria. Int. J. Food Saf. Nutr. Publ. Health, 5: 162-172.
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  34. Fuentes, F., X. Paredes-Gonzalez and A.N. Kong, 2015. Dietary glucosinolates sulforaphane, phenethyl isothiocyanate, indole-3-Carbinol/3,3'-Diindolylmethane: Antioxidative stress/inflammation, Nrf2, epigenetics/epigenomics and in vivo cancer chemopreventive efficacy. Curr. Pharmacol. Rep., 1: 179-196.
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  35. Ugwuja, E.I., N.C. Ugwu, C. Aloke, J.N. Idenyi, A.N. Nwibo, U.A. Ibiam and U.S. Ezenkwa, 2012. Effects of glycaemic status on plasma levels of calcium, chromium, copper, iron, magnesium, selenium and zinc in diabetic rats. Int. J. Diabetes Res., 1: 92-95.
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  36. Aloke, C., N. Nwachukwu, E.I. Ugwuja, J.N. Idenyi, E.U. Nwachi, I.O. Obasi and O. Oga, 2012. Effects of Zanthoxylum zanthoxyloides leaves on plasma glucose, lipid profile and some liver enzymes in alloxan induced diabetic rats. Int. J. Sci. Nature, 3: 497-501.
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  37. Ugwuja, E.I., A.N. Nwibo, N.C. Ugwu and C. Aloke, 2010. Effects of aqueous extract of spices mixture containing curry, garlic and ginger on plasma glucose and lipids in alloxan-induced diabetic rats. Pak. J. Nutr., 9: 1131-1135.
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  38. Ogah, O., U.A. Ibiam, C.A. Afiukwa, C.O. Edeogu, F.N. Nweke and C. Aloke, 2010. The curative effects of Annona muricata extract on paracetamol Induced liver damage. Int. J. Biosci., 5: 18-23.
  39. Idenyi, J.N., N. Nwachukwu, C.O. Edeogu, A.A. Afiukwa, E.I. Ugwuja and C. Aloke, 2010. Antioxidant activity of diet formulated from selected leafy vegetables commonly available and consumed in Abakaliki, Nigeria. Internet J. Altern. Med., Vol. 8 .
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  40. Aloke, C., N. Nwachukwu, J.N. Idenyi, E.I. Ugwuja, E.U. Nwachi, C.O. Edeogu and O. Ogah, 2010. Hypoglycaemic and hypolipidaemic effects of feed formulated with Ceiba pentandra leaves in alloxan induced diabetic rats. Aust. J. Pure Applied Sci., 4: 4473-4477.