Dr. Nkiruka Chinonyelum Azubuike
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Dr. Nkiruka Chinonyelum Azubuike

Associate Professor
University Of Nigeria Nsukka, Nigeria

Highest Degree
Ph.D. in Histopathology from University of Nigeria, Nsukka, Nigeria

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Biography

Nkiruka Azubuike is a qualified Medical Laboratory Scientist from the University of Nigeria, with an MSc and a Ph.D. in Histopathology/Histochemistry in the same University. Her expertise includes Cytological/Histological processing of cells/tissues, biochemical analysis of body fluids, Animal handling & experimentation, statistical analysis. Her research interests include Toxicology, Genotoxicity, Cytogenetics, Biomonitoring, Stem Cell Science and regenerative medicine, Ethnopharmacology.

Area of Interest:

Biomedical Sciences
100%
Histopathology
62%
Histochemistry
90%
Medical Pharmacology
75%
Pathological
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
89
Abstracts
0

Selected Publications

  1. Udoh, I.P., S.T. Aladenika, U.C. Maduakor, E.A. Onyebueke, N.C. Azubuike and A.O. Onyemelukwe, 2021. Comparison of antifungal activities of methanolic leaves extract of Sphenocentrum jollyanum (SJ) pierre (moon seed) and conventional antifungal drugs using Fusarium isolates. PhOL - Pharmacol. Online, 1: 62-73.
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  2. Okwuosa, C.N.,N.C. Azubuike and C.P. Okorie, 2021. Evaluation of changes in biochemical and haematological parameters of albino rats following subacute oral administration of Cinnamomum cassia (cinnamon) extract. Annu. Res. Rev. Biol., 36: 91-99.
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  3. Azubuike, N.C. and O.C. Ejiogu, 2021. Nasal secretion cytology of children attending a primary school in Enugu Metropolis – A preliminary evaluation using the blow-out technique. Eur. J. Med. Health Sci., 3: 13-18.
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  4. Achukwu, P.U., D.N. Ezeasor, C.N. Okwuosa, N.C. Azubike and S.A. Ufelle, 2021. Mercury contamination of fish consumed in Enugu, Southeast Nigeria. World Rural Obs., 13: 77-80.
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  5. Azubuike, N.C. and N.O. Okoli, 2020. Impact of rooibos tea on experimental model of high-fat diet-induced Non-alcoholic fatty liver disease. PhOL-PharmacologyOnLine, 2: 175-182.
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  6. Udoh, I.P., S.T. Aladenika, C.I. Eleazar, E.A. Onyebueke, N.C. Azubuike, C.N. Okwuosa, N.E. Ibezim and C.O. Esimone, 2019. Antifungal properties of methanolic leaf extract of Anacardium occidentale L (cashew) against fusarial isolates from human and plant origin. PhOL - PharmacologyOnLine, 1: 117-135.
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  7. Onwukwe, O.S., P.U. Achukwu, N.C. Azubuike, T.K. Udeani, O.B. Okpukpara and O.D. Sofoluke, 2019. Frequency of buccal cell micronuclei in abattoir workers exposed to smoke from singeing animal hide in Enugu, South East Nigeria. J. Environ. Toxicol. Public Health, 4: 1-5.
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  8. Maduakor, U.C., N.F. Onyemelukwe, S.N. Maduakor, N.C. Azubuike, A.O. Onyemelukwe and E.B. Nnedu, 2019. Bacterial etiology and risk factors of periodontal diseases in Enugu Metropolis, South East Nigeria. Internet J. Microbiol., Vol. 16. .
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  9. Azubuike, N.C., U.C. Maduakor, A.O. Onyemelukwe, O.S. Onwukwe, I.P. Udoh, I.T. Ikele and C.C. Odoh, 2019. Ameliorative effects of ascorbic acid supplementation on mouldy peanut diet-induced histopathological alterations in liver of albino rats. PhOL-PharmacologyOnLine, 1: 57-67.
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  10. Azubuike, N.C., C.N. Okwuosa, U.C. Maduakor, O.S. Onwukwe and C.N. Onyemelukwe et al., 2019. Effects of methanolic extract of Brassica juncea seeds on biochemical parameters and histological integrity of the heart and liver of albino rats. Int. J. Pharmacol., 37: 237-240.
  11. Onwukwe, O.S., N.C. Azubike, T.K. Udeani, A. Obianuju, C.F.C. Onyemelukwe and P.U. Achukwu, 2018. Research article changes in the haematological profile and frequency of nuclear abnormalities in exfoliated buccal cells of automobile welders in Enugu, Nigeria. Res. J. Environ. Toxicol., 12: 56-62.
  12. Onwukwe, O.S., N.C. Azubike, B.C. Eluke, A.O. Onyemelukwe, O.O. Cornelius, J.C. Ikechukwu and P.U. Achukwu, 2018. Evaluation of the antiulcer properties of aqueous and methanol extracts of Vitex doniana on indomethacin induced gastric ulcers in albino rats. Pharmacologyonline, 13: 68-74.
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  13. Odo, O.F., P.U. Achukwu, N.C. Azubuike, O.S. Onwukwe, A.O. Onyemelukwe and A.J. Ekoh, 2018. Sub-acute toxicity profile of aqueous seed extracts of Dacryodes edulis. Der Pharm. Lett., 10: 33-44.
  14. Imo, C., K.A. Arowora, C.S. Ezeonu, O.E. Yakubu, C.D. Nwokwu, N.C. Azubuike and Y.G. Sallah, 2018. Effects of ethanolic extracts of leaf, seed and fruit of Datura metel L. on kidney function of male albino rats. J. Tradit. Complement. Med., (In Press). 10.1016/j.jtcme.2017.09.001.
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  15. Azubuike, N.C., U.C. Maduakor, I.T. Ikele, O.S. Onwukwe and A.O. Onyemelukwe et al., 2018. Nutritional profile, proximate composition and health benefits of Colocasia esculenta leaves: An underutilized leafy vegetable in Nigeria. Pak. J. Nutr., 17: 689-695.
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  16. Azubuike, N.C., O.S. Onwukwe, A.O. Onyemelukwe, U.C. Maduakor, I.M. Ifeorah, C.N. Okwuosa and P.U. Achukwu, 2018. Impact of Colocasia esculenta extract and fractions on high-fat diet-induced changes in body weight, adipose tissue and liver of rats. Pak. J. Pharm. Sci., 31: 2149-2156.
    PubMed  |  
  17. Azubuike, N.C., I.T. Ikele, A.O. Onyemelukwe, U.C. Maduakor and O.S. Onwukwe et al., 2018. Histological staining properties of Khaya senegalensis wood dust extracts: A preliminary study. Anat. J. Afr., 7: 1314-1321.
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  18. Azubuike, N.C., C.N. Onyemelukwe, U.C. Maduakor, O.S. Onwukwe and A.C. Ezeh, 2018. Hepatoprotective effect of leaf extracts of Cassia occidentalis against carbon-tetrachloride-induced hepatotoxicity in albino rats. Pharmacologyonline, 14: 68-74.
  19. Azubuike, N.C., C.N. Okwuosa, O.S. Onwukwe, A.O. Onyemelukwe, I.T. Ikele and P.U. Achukwu, 2018. Effects of Phyllanthus amarus on epididymal sperm characteristics, testosterone levels and histology of reproductive organs of male rats. Pharmacologyonline, 14: 57-67.
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  20. Azubuike, N.C. and K.U. Onwusi, 2018. Evaluation of a new technique for supporting anatomical museum specimens-A comparative study. Int. J. Anat. Res., 6: 5929-5935.
  21. Okwuosa, C.N., N.C. Azubike, D.C. Nwachukwu, A.C. Onuba and E.N. Shu, 2017. Effect of crude methanol leaf extract of Combretum racemosum on histamine-stimulated gastric secretion in rats. J. Coastal Life Med. Eng. Technol., 5: 77-81.
  22. Nwachukwu, D.C., E.I. Aneke, N.Z. Nwachukwu, N. Azubike and L.F. Obika, 2017. Does consumption of an aqueous extract of Hibscus sabdariffa affect renal function in subjects with mild to moderate hypertension? J. Physiol. Sci., 67: 227-234.
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  23. Nwachukwu, D.C., A. Eze, N.Z. Nwachukwu, E.I. Aneke and P. Agu et al., 2017. Monotherapy with amlodipine or hydrochlorothiazide in patients with mild to moderate hypertension: Comparison of their efficacy and effects on electrolytes. Malawi Med. J., 29: 108-112.
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  24. Azubike, N.C., C.N. Okwuosa, D.C. Nwachukwu, A.O. Onyemelukwe and O.S. Onwukwe et al., 2017. In vivo hepatoprotective studies on saponin and alkaloid rich fractions isolated from Colocasia esculenta [L. Schott] leaves. Pharmacologyonline, 12: 66-74.
  25. Steven, O.O., A.P. Uwadiegwu, A.N. Chinonyelum, N.D. Chukwu, O.A. Obianuju, U.I. Kingsley and E.B. Chekwube, 2016. Preliminary studies on the anti-ulcer potentials of Vitex doniana crude extracts on experimental rat model of ethanol induced gastric ulcer. Asian Pac. J. Trop. Dis., 6: 736-740.
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  26. Okwuosa, C.N., E.N. Shu, N.C. Azubike, D.C. Nwachukwu and A.C. Onuba et al., 2016. Anti-diarrhoeal properties of the leaf extracts of Combretum racemosum P. Beauv in rodents. Der Pharm. Lett., 8: 207-213.
  27. Nwachukwu, D.C., E.I. Aneke, N.Z. Nwachukwu, N. Azubike and L.F. Obika, 2016. Thirst perception in mild to moderate hypertensive nigerians treated with aqueous extract of Hibiscus sabdariffa L. Afr. J. Pharm. Pharmacol., 10: 403-410.
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  28. Azubike, N.C., P.U. Achukwu, C.N. Okwuosa, D.C. Nwachukwu, O.S. Onwukwe and A.O. Onyemelukwe, 2016. Subacute toxicity profile of the leaves of Colocasia esculenta[L. Schott] in albino rats. Res. J. Med. Plants, 10: 340-348.
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  29. Imo, C., F.O. Uhegbu, N.G. Ifeanacho and N.C. Azubuike, 2015. Histological and hepatoprotective effect of ethanolic leaf extract of Gongronema latifolium Benth in acetaminophen-induced hepatic toxicity in male albino rats. Int. J. Prev. Med. Res., 1: 217-226.
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  30. Chinonyelum, A.N., A.P. Uwadiegwu, O.C. Nwachukwu and O. Emmanuel, 2015. Evaluation of hepatoprotective activity of Colocasia esculenta (L. Schott) leaves on thioacetamide-induced hepatotoxicity in rats. Pak. J. Pharm. Sci., 29: 2237-2241.
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  31. Azubike, N.C., C.N. Okwuosa, P.U. Achukwu, T.C. Maduka, O. Chike, 2015. Acute toxicity and histopathological effects of crude aqueous extract of Jatropha curcas leaves in mice. Res. J. Med. Plants, 9: 340-346.
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  32. Okwuosa, C.N., N.C. Azubike, V.N. Emenuga and O.S. Onwukwe, 2013. The in-vitro assessment of antioxidant activities of Persea Americana Mill leaf extract. Afr. J. Sci., 14: 3182-3193.
  33. Okwuosa, C.N., N.C. Azubike, O.S. Onwukwe and V.N. Emenuga, 2013. Hepatoprotective effect of Monodora myristica seed extracts against carbon tetrachloride induced liver injury in guinea pigs. World J. Biotechnol., 14: 2222-2229.
  34. Okwuosa, C.N., N.C. Azubike, I.C. Anioke, A.O. Onyemelukwe, O.S. Onwukwe and C. Eze, 2013. Evaluation of the biochemical and toxicological effect of the crude methanol leaf extract of Momordica charantia in rats. J. Applied Sci., 16: 10813-10824.
  35. Azubike, N.C., O.S. Onwukwe, C.N. Okwuosa, V.N. Emenuga, C.K. Tabansi and P.U. Achukwu, 2013. Hepatoprotective effect of Colocasia esculenta leaf extract on acetaminophen-induced liver injury in albino wistar rats. Afr. J. Sci., 14: 3283-3294.
  36. Azubike, N.C., C.N. Okwuosa, O.S. Onwukwe, V.N. Emenuga and C.C. Eze, 2013. Inhaled smoke from burnt Carica papaya Leaves exerts deleterious effects on the lungs, liver and heart of rats. World J. Biotechnol., 14: 2176-2182.
  37. Azubike, N.C., C.N. Okwuosa, O.S. Onwukwe, I.C. Anioke, O.F. Odo and J. Ezugwu, 2013. The sub-acute effect of exposure to smoke from Carica papaya leaves on testis and brain of albino wistar rats. J. Sci. Eng. Technol., 20: 11305-11313.
  38. Azubike, N.C., C.N. Okwuosa, O.S. Onwukwe, C. Nnorom, O.F. Odo and I.C. Anioke, 2013. Effects of two topical herbal medications on the skin of albino wistar rats. J. Applied Sci., 16: 10969-10975.
  39. Azubike, N.C., C.N. Okwuosa, O.S. Onwukwe, A.O. Onyemelukwe, I.C. Anioke and D.N. Mbaukwu, 2013. Common errors detected on prepared slides for histological examination from two morbid anatomy laboratories in Enugu State. J. Sci. Eng. Technol., 20: 11348-11357.
  40. Adisa, J.O., E. Egbujo, P.O. Egbujo, J. Madukwe, A. Egbujo and N.C. Azubike, 2013. Immunohistochemistry and antigenic expression of five proteins in kaposi sarcoma. Int. J. Biomed. Adv. Res., 4: 574-578.
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  41. kwuosa, C.N., N.C. Azubike, A.C. Onuba, P.U. Achukwu and C.U. Chinwuba, 2012. Hepatoprotective activity of the crude leaf extracts of Phyllantus muellerianus against acetaminophen induced liver injury in wistar rats. J. Sci. Eng. Technol., 19: 11152-11164.
  42. Okwuosa, C.N., P.U.O. Achukwu, N.C. Azubike and A.I.E. Abah, 2012. Protective effect of the leaf extracts of Combretum racemosum P. Beauv (Combretaceae) on cyclophosphamide induced pancytopaenia and liver injury in male rats. Res. J. Pharmacol., 6: 30-34.
  43. Okwuosa, C.N., P.U.O. Achukwu and N.C. Azubike, 2012. The effect of lipoic acid and thiamin co-supplementation on blood glucose and lipid levels of alloxanized rats. J. Sci. Eng. Technol., 19: 10713-10725.
  44. Okwuosa, C.N., N.C. Azubike and P.U.O. Achukwu, 2012. The protective effect of zinc supplementation on cyclophosphamide induced cellular toxicity in rats. J. Sci. Eng. Technol., 19: 10568-10579.
  45. Okwuosa, C.N., D.C. Nwachukwu and N.C. Azubike, 2012. Effect of Aspilia Africana on necrotizing agent induced gastric ulcer and gastric motility. Indian J. Novel Drug Discov., 4: 110-114.
  46. Azubike, N.C., P.U.O. Achukwu and C.N. Okwuosa, 2012. Exfoliated buccal cell micronuclei frequency in smokers and non-smokers. J. Applied Sci. 15: 10298-10309.
  47. Azubike, N.C., P.U. Achukwu and C.N. Okwuosa, 2012. Preliminary assessment of the phytochemicals and toxicity testing of Colocasia esculenta. J. Applied Sci., 15: 10783-10796.
  48. Azubike, N.C., C.N. Okwuosa and P.U. Achukwu, 2012. Toxicological evaluation of methanol leaf extract of Cassia siamea in albino wistar rats. J. Applied Sci., 15: 10170-10181.
  49. Achukwu, P.U., D.N. Ezeasor, C.N. Okwuosa, N.C. Azubike and O.S. Onwukwe, 2012. Determination of levels of mercury (Hg) contamination of water bodies in enugu metropolis and some major water bodies in South-East Nigeria. J. Environ. Manage. Saf., 3: 81-85.
  50. Okwuosa, C.N., R. Okoi-Ewa, P.U. Achukwu, A.C. Onuba and N.C. Azubike, 2011. Gastroprotective effect of crude hexane leaf extracts of Sesamum indicum in rabbits. Niger. J. Physiol. Sci., 26: 49-54.
  51. Okwuosa, C.N., P.U.O. Achukwu, N.C. Azubike and M. Alu, 2011. Effect of zinc and selenium supplementation in thioacetamide induced liver damage. J. Sci. Eng. Technol., 18: 9875-9885.
  52. Okwuosa, C.N., N.C. Azubuike and I.I. Nebo, 2011. Evaluation of the anti-hyperglycaemic activity of the crude extract of Sida acuta in normal and diabetic rabbits. Indian J. Novel Drug Delivery, 3: 206-213.
  53. Okwuosa, C.N., N.C. Azubike, P.U.O. Achukwu and Q.N. Udeh, 2011. Effect of norfloxacin administration on experimental iron overload in rats. J. Applied Sci., 14: 9428-9439.
  54. Nwachukwu, D.C., C.N. Okwuosa, P.U. Chukwu, N. Azubuike and T. Udeani, 2011. Hepatoprotective activity of methanol extract of the seeds of Sesamum indicum in carbon tetrachloride induced hepatotoxicity in rats. Ind. J. Novel Drug. Delivery, 3: 36-42.
  55. Azubike, N.C., P.U.O. Achukwu, C.N. Okwuosa and D.E. Nwaeze, 2011. Comparison of a commercial hair spray and conventional fixatives for fixation in urine cytology. J. Applied Sci., 14: 9525-9534.
  56. Azubike, N.C., P.U. Achukwu, C.N. Okwuosa, Y. Ajayi and A.C. Ugwu, 2011. Extracts of Lawsonia inermis and Hibiscus sabdarriffa as stains for histological sections. J. Sci. Eng. Technol., 18: 9944-9952.
  57. Achukwu, P.U.O., N.C. Azubike and O.S. Onwukwe, 2011. Mastitis: A brief review of causes, management and prevention. Health Scienza, 2: 45-47.
  58. Okwuosa, C.N., P.U.O. Achukwu and N.C. Azubike, 2010. Biochemical and toxicological studies on the crude leaf extracts of Abrus precatorius in rats. J. Applied Sci., 13: 9165-9175.
  59. Okwuosa, C.N., P.U. Achukwu, T.K.C. Udeani, N.C. Azubike and D.I. Uguru, 2010. Lipid lowering activity of the leaf extracts of Vitex doniana in cholesterol fed guinea pigs. West Afr. J. Pharmacol. Drug Res., 26: 36-42.
  60. Nwachukwu, D.C., C.N. Okwuosa, P.U. Achukwu, N.C. Azubike and G. Eze, 2010. Anti-hyperglycemic activity of the leaf extracts of Solanum dulcamara in diabetic rats. Indian J. Novel Drug Deliv., 2: 138-143.
  61. Azubike, N.C., P.U.O. Achukwu, C.N. Okwuosa and B. Atoigwe, 2010. Lawsonia inermis leaf extracts as natural histological stains. J. Sci. Eng. Technol., 17: 9380-9390.
  62. Azubike, N.C., C.N. Okwuosa, P.U.O. Achukwu and T.K.C. Udeani, 2010. Anti-hyperglycemic activity of Portulaca oleracea in glucose fed normal rats. J. Applied Sci., 13: 8986-8998.
  63. Achukwu, P.U.O., N.C. Azubike, C.N. Okwuosa and O.S. Onwukwe, 2010. Renoprotective effects of orally administered aqueous extract of Tridax procumbens on gentamicin induced nephrotoxicity in albino wistar rats. J. Exp. Clin. Anat., 9: 47-52.
  64. Achukwu, P.U.O., N.C. Azubike and C.N.C. Onyewuenyi, 2010. Hepatoprotective effect of the crude leaf extracts of Portulaca oleracea in carbon tetrachloride induced liver injury in rodents. J. Exp. Clin. Anat., 9: 1-7.
  65. Achukwu, P.U.O., C.N. Okwuosa, N.C. Azubike and N.C. Nwaebiem, 2010. Lipid lowering property of the leaf extracts of Sida acuta in cholesterol fed rats. J. Sci. Eng. Technol., 17: 9534-9545.
  66. Udeani, T.K.C., A.A. Obroh, C.N. Okwuosa, P.U. Achukwu and N. Azubike, 2009. Isolation of bacteria from mechanic workshops’ soil environment contaminated with used engine oil. Afr. J. Biotechnol., 8: 6301-6303.
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  67. Okwuosa, C.N., P.U. Achukwu, S.A. Ufelle, N.C. Azubike and C.M. Nwabuilo, 2009. Haematological and biochemical changes in acetaminophen induced organ injury in rats exposed to extracts of Canarium schweinfurthii. J. Med. Res. Technol., 6: 8-22.
  68. Okwuosa, C.N., P.U. Achukwu, D.C. Nwachukwu, A.A. Eze and N.C. Azubuike, 2009. Nephroprotective activity of stem bark extracts of Canarium schweinfurthii on acetaminophen-induced renal injuries in rats. Int. J. Med. Health Dev., 14: 6-13.
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  69. Okwuosa, C.N., N.C. Azubike, P.U.O. Achukwu, P.C. Unekwe, T.K.C. Udeani and A.N. Ossai, 2009. Biochemical and toxicological studies of the seed extracts of Dennettia tripettia in male Hartley-dunkin guinea-pigs. J. Sci. Eng. Technol., 16: 8965-8975.
  70. Azubuike, N.C., P.U.O. Achukwu, C.N. Okwuosa and A.U. Katchy, 2009. The sub-acute effect of Phyllanthus amarus on the histology of liver and kidney of male albino wistar rats. World J. Biotechnol., 10: 1619-1624.
  71. Azubike, N.C., C.N. Okwuosa, P.U.O. Achukwu and C.O. Ugwuoke, 2009. Cholesterol Lowering property of the leaf extracts of Combretum racemosum in rats. Afr. J. Sci., 10: 2429-2437.
  72. Achukwu, P.U.O., N.C. Azubike, C.N. Okwuosa and T.O. Onu, 2009. Toxicological study of the aqueous leaf extracts of Mucuna flagillipes on albino wistar rats. Afr. J. Sci., 10: 2293-2303.
  73. Achukwu, P.U., C.N. Okwuosa, N.C. Azubuike and C.C. Adimekwe, 2009. Studies on the anti-ulcer properties of the leaf extracts of Cassia occidentalis. J. Med. Res. Technol., 6: 10-17.
  74. Onyeanusi, J.C., C.N. Okwuosa, N.C. Azubike, P.U.O. Achukwu and S.I. Okosi, 2008. Studies on the effect of sub-acute administration of Citrullus lanatus on serum protein levels of male albino wistar rats. J. Sci. Eng. Technol., 15: 8299-8304.