Prof. Dr. Nor  Fadilah Rajab
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Prof. Dr. Nor Fadilah Rajab

Associate Professor
Universiti Kebangsaan Malaysia, Malaysia


Highest Degree
D.Phil in Biomedical Sciences from University of Ulster, U.K.

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Biography

Dr. Nor Fadilah Rajab is currently working as Head and Associate Professor at Universiti Kebangsaan Malaysia, Malaysia. She has completed her Ph.D. in Biomedical Sciences from same University. Her area of research interest focuses on Cytotoxicity and Genotoxicity of active compound from Natural and Chemical sources Male Infertility study Genotoxicity study on Electromagnetic Irradiation. She has published 81 research articles in journals contributed as author/co-author.

Area of Interest:

Biomedical Sciences
100%
Biotechnology
62%
Molecular Biology
90%
Molecular Genetics
75%
Molecular Toxicology
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
0
Abstracts
0

Selected Publications

  1. Meramat, A., N.F. Rajab, S. Shahar and R. Sharif, 2015. Cognitive impairment, genomic instability and trace elements. J. Nutr. Health Aging, 19: 48-57.
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  2. Khan, N., Y. Farina, L.K. Mun, N.F. Rajab and N. Awang, 2015. Syntheses, characterization, X-ray diffraction studies and in vitro antitumor activities of diorganotin (IV) derivatives of bis (p-substituted-N-methylbenzylaminedithiocarbamates). Polyhedron, 85: 754-760.
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  3. Chow, P.W., Z.A. Hamid, K.M. Chan, S.H. Inayat-Hussain and N.F. Rajab, 2015. Lineage-related cytotoxicity and clonogenic profile of 1, 4-benzoquinone-exposed hematopoietic stem and progenitor cells. Toxicol. Applied Pharmacol., 284: 8-15.
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  4. Shahirah, N.N., M.Y.F. Zuraina, R.N. Fadilah, C.F.S. Zaila, L. Florinsiah, M.N. Norfazlina and L.L. Mun, 2014. Cytotoxicity and genotoxicity of selected medicinal mushroom used in traditional medicine. Res. Rev. Biosci., 8: 473-480.
  5. Rajab, N.F., H.K. Yen, A.R. Fauzi, L.B. Din, V.J. McKelvey-Martin, C.K. Meng and S.H. Inayat-Hussain, 2014. Involvement of Seladin-1 in goniothalamin-induced apoptosis in urinary bladder cancer cells. BMC Complement. Altern. Med., Vol. 14. 10.1186/1472-6882-14-295.
    CrossRef  |  
  6. Norfazlina, M.N., M.Y.F. Zuraina, N.F. Rajab, S.M. Nazip and A.R. Rumiza et al., 2014. In vitro cytotoxicity effects of single and combination Nigella sativa and Zingiber zerumbet extracts on human myeloid leukemia (HL60) cells and its mode of cell death. J. Applied Pharm. Sci., 4: 051-055.
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  7. Ng, P.L., N.F. Rajab, S.M. Then, Y.A.M. Yusof, W.Z.W. Ngah, K.Y. Pin and M.L. Looi, 2014. Piper betle leaf extract enhances the cytotoxicity effect of 5-fluorouracil in inhibiting the growth of HT29 and HCT116 colon cancer cells. J. Zhejiang Univ. Sci. B, 15: 692-700.
    CrossRef  |  
  8. Mohamad, N., M.C.I.M. Amin, M. Pandey, N. Ahmad and N.F. Rajab, 2014. Bacterial cellulose/acrylic acid hydrogel synthesized via electron beam irradiation: Accelerated burn wound healing in an animal model. Carbohydr. Polym., 114: 312-320.
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  9. Khan, N., Y. Farina, L.K. Mun, N.F. Rajab and N. Awang, 2014. Triorganotin (IV) complexes with o-substituted arylhydroxamates: Synthesis, spectroscopic characterization, X-ray structures and in vitro cytotoxic activities. J. Organometallic Chem., 763: 26-33.
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  10. Khan, N., Y. Farina, L.K. Mun, N.F. Rajab and N. Awang, 2014. Syntheses, spectral characterization, X-ray studies and in vitro cytotoxic activities of triorganotin (IV) derivatives of p-substituted N-methylbenzylaminedithiocarbamates. J. Mol. Struct., 1076: 403-410.
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  11. Awang, M.A., M.F. Abu Bakar, M.F. Busra, S.R. Chowdhury and N.F. Rajab et al., 2014. Cytotoxic evaluation of biomechanically improved crosslinked ovine collagen on human dermal fibroblasts. Biomed. Mater Eng., 24: 1715-1724.
  12. Amiera, Z.U.R., M. Nihayah, I.F. Wahida and N.F. Rajab, 2014. Phytochemical characteristic and uterotonic effect of aqueous extract of Ficus deltoidea leaves in rats uterus. Pak. J. Biol. Sci., 17: 1046-1051.
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  13. Ahmad, T.A.T., F. Jaafar, Z. Jubri, K.A. Rahim, N.F. Rajab and S. Makpol, 2014. Gelam honey attenuated radiation-induced cell death in human diploid fibroblasts by promoting cell cycle progression and inhibiting apoptosis. BMC Complement. Altern. Med., Vol. 14. 10.1186/1472-6882-14-108.
    CrossRef  |  
  14. Abdul Hamid, Z., W.H.L. Lin, B.J. Abdalla, O.B. Yuen and E.S. Latif et al., 2014. The role of Hibiscus sabdariffa L. (Roselle) in maintenance of Ex Vivo murine bone Marrow-derived hematopoietic stem cells. Scient. World J., 10.1155/2014/258192.
    CrossRef  |  
  15. Zaila, C.S., M.F. Zuraina, M.N. Norfazlina, L.L. Mun and N. Nurshahirah, 2013. Anti-proliferative effect of Lignosus rhinocerotis, the Tiger's milk mushroom, on HCT 116 human colorectal cancer cells. Open Conf. Proc. J., 4: 65-70.
  16. Teng, N.I.M.F., S. Shahar, N.F. Rajab, Z.A. Manaf, M.H. Johari and W.Z.W. Ngah, 2013. Improvement of metabolic parameters in healthy older adult men following a fasting calorie restriction intervention. Aging Male, 16: 177-183.
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  17. Shahar, S., L.K. Lee, N. Rajab, C.L. Lim and N.A. Harun et al., 2013. Association between vitamin A, vitamin E and apolipoprotein E status with mild cognitive impairment among elderly people in low-cost residential areas. Nutr. Neurosci., 16: 6-12.
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  18. Pirabbasi, E., M. Najafiyan, M. Cheraghi, S. Shahar, Z.A. Manaf, N. Rajab and R.A. Manap, 2013. What are the antioxidant status predictor's factors among male Chronic Obstructive Pulmonary Disease (COPD) Patients? Global J. Health Sci., 5: 70-78.
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  19. Norfazlina, M.N., M.Y.F. Zuraina, N.F. Rajab, S.M. Nazip and A.R. Rumiza et al., 2013. Cytotoxicity study of Nigella sativa and Zingiber zerumbet extracts, thymoquinone and zerumbone isolated on human myeloid leukemia (HL60) cell. Open Conf. Proc. J., 4: 99-107.
  20. Naqeebullah, K., Y. Farina, L.K. Mun, N.F. Rajab and N. Awang, 2013. Spectral characterization and crystal structures of two newly synthesized ligands of N-methyl O-substituted benzohydroxamic acids. J. Chem. Crystallogr., 43: 622-627.
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  21. Lee, L.K., S. Shahar, N. Rajab, N.A.M. Yusoff, R.A. Jamal and S.M. Then, 2013. The role of long chain omega-3 polyunsaturated fatty acids in reducing lipid peroxidation among elderly patients with mild cognitive impairment: A case-control study. J. Nutr. Biochem., 24: 803-808.
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  22. Kamarozaman, A.S., J. Latip, Y.M. Syah, N. Rajab and A. Jaloh, 2013. Oligostilbenoids from Vatica pauciflora and the oxidative effect on Chang cells. J. Phys. Conf. Ser., Vol. 423. 10.1088/1742-6596/423/1/012045.
    CrossRef  |  
  23. Ghazali, A.R., R.M. Halim, N.F. Rajab, N. Ramli, R. Abdullah, F. Kamarulzaman and Z. Harun, 2013. Gene mutation effect of aqueous and methanol extracts of salted fish from pulau pinang, Malaysia towards V79 lung fibroblast cells. Sains Malaysiana, 42: 1599-1603.
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  24. Florinsiah, L., M.Y.F. Zuraina, N.N. Shahirah, M.N. Norfazlina, C.F.S. Zaila and N.F. Rajab, 2013. Mutagenicity effect of hydrocotyle bonariensis extracts in salmonella/microsome assay. Int. J. Pharm. Sci. Rev. Res., 20: 47-50.
    Direct Link  |  
  25. Farina, Y., K.M. Chan, L.K. Mun, N.F. Rajab and T.C. Ooi, 2013. Diorganotin (IV) derivatives of N-methyl p-Fluorobenzo-hydroxamic acid: Preparation, spectral characterization, X-ray diffraction studies and antitumor activity. Molecules, 18: 8696-8711.
  26. Ahmad, T.A.F.T., Z. Jubri, N.F. Rajab, K.A. Rahim, Y.A.M. Yusof and S. Makpol, 2013. Gelam honey protects against gamma-irradiation damage to antioxidant enzymes in human diploid fibroblasts. Molecules, 18: 2200-2211.
  27. Roslie, H., K.M. Chan, N.F. Rajab, S.S. Velu and S.A.A.S. Abd Kadir et al., 2012. 3,5-Dibenzyloxy-4'-hydroxystilbene induces early caspase-9activation during apoptosis in human K562 chronicmyelogenous leukemia cells. J. Toxicol. Sci., 37: 13-21.
  28. Pirabbasi, E., M. Najafiyan, M. Cheraghi, S. Shahar, Z.A. Manaf, N. Rajab and R.A. Manap, 2012. Predictor's factors of nutritional status of male chronic obstructive pulmonary disease patients. Int. Schol. Res. Notic., 10.5402/2012/782626.
    CrossRef  |  
  29. Nakisah, M.A., M.I. Muryany, H. Fatimah, R.N. Fadilah, M.R. Zalilawati, S. Khamsah and M. Habsah, 2012. Anti-amoebic properties of a Malaysian marine sponge Aaptos sp. on Acanthamoeba castellanii. World J. Microbiol. Biotechnol., 28: 1237-1244.
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  30. Makpol, S., T.A.F.T. Ahmad, Z. Jubri, N. Rejab, N. Yusof and Y.A.M. Yusof, 2012. Gelam honey acting as a radioprotectant agent in gamma-irradiated human diploid fibroblasts. J. Med. Plant Res., 6: 129-138.
  31. Lee, L.K., S. Shahar, A.V. Chin, N.A.M. Yusoff, N. Rajab and S.A. Aziz, 2012. Prevalence of gender disparities and predictors affecting the occurrence of Mild Cognitive Impairment (MCI). Arch. Gerontol. Geriatrics, 54: 185-191.
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  32. Ghazali, A.R., Y. Sipain, N.F. Rajab, S.E. Ling and N. Ramli et al., 2012. Genotoxic potential of shrimp pastes (Belacan) extracts using Umu test. Food Nutr. Sci., 3: 522-525.
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  33. Chan, K.M., R. Hamzah, A.A. Rahaman, V.Y.M. Jong and H.Y. Khong et al., 2012. The pyranoxanthone inophyllin A induces oxidative stress mediated-apoptosis in Jurkat T lymphoblastic leukemia cells. Food Chem. Toxicol., 50: 2916-2922.
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  34. Awang, N., N.F. Kamaludin, A. Hamid, N.W.N. Mokhtar and N.F. Rajab, 2012. Cytotoxicity of Triphenyltin (IV) Methyl- and Ethylisopropyldithiocarbamate compounds in chronic myelogenus leukemia cell line (K-562). Pak. J. Biol. Sci., 15: 833-838..
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  35. Shahar, S., S. Shafurah, N.S.H. Shaari, R. Rajikan, N.F. Rajab, B. Golkhalkhali and Z.M. Zainuddin, 2011. Roles of diet, lifetime physical activity and oxidative DNA damage in the occurrence of prostate cancer among men in Klang Valley, Malaysia. Asian Pac. J. Cancer Prev., 12: 605-611.
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  36. Salleh, S.A., N.F. Rajab, N.R. Abdullah, Z. Ismail, P. Mouatt, A. Dowell and S. Muhamad, 2011. In vitro chemopreventive activity of an ethyl acetate fraction derived from hot water extract of Orthosiphon stamineus in HepG2 cells. J. Med. Plants Res., 5: 1892-1899.
  37. Othman, H., A. Hamid, S.B. Budin and N.F. Rajab, 2011. The effectiveness of learning intervention program among first year students of biomedical science program. Proc.-Soc. Behav. Sci., 18: 367-371.
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  38. Normah, A., K.N. Farahana, B. Ester, H. Asmah, N. Rajab and A.A. Halim, 2011. Cytotoxic and genotoxic effect of triphenyltin (IV) benzylisopropyldithiocarbamate in thymoma murine cell line (WEHI 7.2). Res. J. Chem. Environ., 15: 544-549.
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  39. Ghazali, A.R., R. Abdullah, N. Ramli, N.F. Rajab, M.S. Ahmad-Kamal and N.A. Yahya, 2011. Mutagenic and antimutagenic activities of Mitragyna speciosa Korth extract using Ames test. J. Med. Plants Res., 5: 1345-1348.
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  40. Udzir, S.S., N.F. Rajab, A.R. Ghazali, E.N.E. Muda, M.A. Abu Bakar and P. Morat, 2010. The effect of Solanum Torvum fruit extract on the liver and aorta: A histological observation of high cholesterol-fed guinea pigs. Malays. J. Microscopy, 4: 58-63.
  41. Kong, K.W., H.E. Khoo, K.N. Prasad, A. Ismail, C.P. Tan and N.F. Rajab, 2010. Revealing the power of the natural red pigment lycopene. Molecules, 15: 959-987.
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  42. Kong, K.W., A. Ismail, C.P. Tan and N.F. Rajab, 2010. Optimization of oven drying conditions for lycopene content and lipophilic antioxidant capacity in a by-product of the pink guava puree industry using response surface methodology. LWT-Food Sci. Technol., 43: 729-735.
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  43. Kong, K.K., N.F. Rajab, K.N. Prasad, A. Ismai, M. Markom and C.P. Tan, 2010. Lycopene-rich fractions derived from pink guava by-product and their potential activity towards hydrogen peroxide-induced cellular and DNA damage. Food Chem., 123: 1142-1148.
    CrossRef  |  
  44. Inayat-Hussain, S.H., K.M. Chan, N.F. Rajab, L.B. Din and S.C. Chow et al., 2010. Goniothalamin-induced oxidative stress, DNA damage and apoptosis via caspase-2 independent and Bcl-2 independent pathways in Jurkat T-cells. Toxicol. Lett., 193: 108-114.
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  45. Inayat-Hussain, S.H., H.A. Ibrahim, E.L. Siew, N.F. Rajab, K.M. Chan, G.T. Williams and D. Ross, 2010. Modulation of the benzene metabolite hydroquinone induced toxicity: Evidence for an important role of fau. Chemico-biol. Interact., 184: 310-312.
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  46. Chan, K.M., N.F. Rajab, D. Siegel, L.B. Din, D. Ross and S.H. Inayat-Hussain, 2010. Goniothalamin induces coronary artery smooth muscle cells apoptosis: The p53-dependent caspase-2 activation pathway. Toxicol. Sci., 116: 533-548.
    CrossRef  |  
  47. Awang, N., N.S.A.M. Yousof, I. Baba, N.F. Rajab, A. Hamid, B.M. Yamin and A. Abdul Halim, 2010. Synthesis and characterization of organotin (IV) N-Methyl-N-Isopropyldithiocarbamate compounds: X-Ray Crystal Structure of (CH3)2Sn[S2CN(CH3)(i-C3H7)]2. World Applied Sci. J., 9: 804-810.
  48. Taib, I.S., S.B. Budin, S.M. Siti Nor Ain, J. Mohamed and S.R. Louis et al., 2009. Toxic effects of Litsea elliptica, Blume essential oil on red blood cells of Sprague-dawley rats. J. Zhejiang Univ. Sci. B, 10: 813-819.
  49. Ling, S.E., N.F. Rajab, A.B. Osman, K. Sudesh and S.H. Inayat-Hussain, 2009. Mutagenic and clastogenic characterization of post sterilized poly(3-hydroxybutyrate-co-4-hydroxyvutyrate) copolymer biosynthesized by Delftia acidovorans. J. Biomed. Mater. Res.: Part A, 91: 786-794.
  50. Lee, L.K., S. Shahar and N.F. Rajab, 2009. Serum folate concentration, cognitive impairment, and DNA damage among elderly individuals in Malaysia. Nutr. Res., 29: 327-334.
  51. Inayat-Hussain, S.H., L.T. Wong, K.M. Chan, N.F. Rajab and L.B. Din et al., 2009. RACK-1 overexpression protects against goniothalamin-induced cell death. Toxicol. Lett., 191: 118-122.
  52. Suzana, S., H. Normah, A. Fatimah, R.N. Fadilah and G.A. Rohi et al., 2008. Antioxidants intake and status and oxidative stress in relation to breast cancer risks: A case-control study. Asian Pacific J. Cancer Prevent., 9: 343-350.
  53. Sharif, R., A.R. Ghazali, N.F. Rajab, H. Haron and F. Osman, 2008. Toxicological evaluation of some Malaysian locally processed raw food products. Food Chem. Toxicol., 46: 368-374.
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  54. Shahar, S., K.T. Teng, N.F. Rajab and F. Arshad, 2008. Association between oxidative DNA damage, fruits and vegetables intake with breast cancer: A pleminary study in Klang Valley. Malays. J. Health Sci., 6: 61-77.
  55. Balkis, B.S., R. Nor Fadilah, A. Ezlan, O. Khairul, A.B. Mokhtar and M. Jamaludin, 2008. Oxidative stress and DNA damage in streptozotocin-induced diabetic rats: Effects of alpha lipoic acid. J. Boil. Sci., 8: 622-627.
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  56. Sharif, R., A.R. Ghazali and N.F. Rajab, 2007. DNA damaging effect of selected salted and fermented food products against Chang Liver cell. Malays. J. Health Sci., 5: 63-77.
  57. Salleh, R.M., S. Shahar, F. Arshad, A.R. Ghazali, N. Haron and N.F. Rajab, 2007. Abdominal obesity increased breast cancer risk. Malays. J. Health Sci., 5: 17-28.
  58. Ee Ling, S., N.F. Rajab, A.B. Osman, K. Sudesh and S.H. Inayat-Hussain, 2007. In vitro biocompatibility evaluation of poly (3-hydroxybutyrate-co-4-hydroxybutyrate)[P(3HB-co-4HB)] copolymer in fibroblast cells. J. Biomed. Mater. Res. Part A, 81A: 317-325.
  59. Bastami, M.S., S.P.M. Bohari, W.M. Har, M.N. Wahab, A.S. Rahmani, N.F. Rajab and M. Hamid, 2007. Hypoglycemic, Isulinotrophic and cytotoxic activity of three species of Ganoderma. Malays. J. Sci., 26: 41-46.
  60. Balkis, B.S., N.F. Rajab, O. Faizah, R. Megat, R. Santhana, A.B. Mokhtar and M. Jamaludin, 2007. The occurrence of early atherosclerosis process in the aorta of streptozoxin-induced diabetic rats. J. Microscopy Soc. Thailand, 21: 131-135.
  61. Asmah, H., A.A. Manaf, R.N. Fadilah, N.B. Alitheen, H. Sirat and A. Abu Bakar, 2007. Zerumbone causes morphological changes on different types of leukemic cell lines. J. Micros. Soc. Thailand, 21: 126-130.
  62. Rajab, N.F., D.J. McKenna, J. Diamond, K. Williamson, P.W. Hamilton and V.J. McKelvey‐Martin, 2006. Prediction of radiosensitivity in human bladder cell lines using nuclear chromatin phenotype. Cytometry Part A, 69: 1077-1085.
    CrossRef  |  
  63. Chan, K.M., N.F. Rajab, M.H.A. Ishak, A.M. Ali, K. Yusoff, L.B. Din and S.H. Inayat-Hussain, 2006. Goniothalamin induces apoptosis in vascular smooth muscle cells. Chem. Biol. Interact., 159: 129-140.
    CrossRef  |  PubMed  |  Direct Link  |  
  64. Budin, S.B., N.F. Rajab, K. Osman, A.G.M. Top, W.N.W. Mohamud, M.A. Bakar and J. Mohamed, 2006. Effects of palm vitamin E against oxidative damage in Streptozotocin-induced diabetic rats. Malays. J. Biochem. Mol. Biol., 13: 11-17.
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  65. Rohi, A.G., R.N. Fadilah, S. Razinah, H. Hasnah and O. Fadzil, 2005. Levels of contaminants in several local raw food products. J. Environ. Health, 2: 18-21.
  66. Rajab, N.F., Z.A. Hamid, H. Hassan, A.M. Ali, L.B. Din and S.H. Inayat-Hussain, 2005. Cytotoxicity and genotoxicity effect of styrylpyrone derivative goniothalamin in leukemic cells. Environ. Mutagen Res., 27: 161-164.
  67. Ghazali, A.R., N.F. Rajab, R. Sharif, T.A. Yaakob and F. Arshad, 2005. The genotoxicological evaluation of several local raw foods extracts on chang liver cells by single cell electrophoresis assay. Environ. Mutagen Res., 27: 165-170.
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  68. Budin, S.B., R.N. Fadilah, M.T.A. Ghapor, W.M.W. Nazaimoon, A.B. Mokhtar, O. Khairul and M. Jamaludin, 2005. Assessment of DNA strand breakage in Streptozoxin-induced diabetic rats. Malays. J. Health Sci., 3: 19-28.
  69. Rajab, N.F., T.A. Yaakob, B.Y. Ong, M. Hamid, A.M. Ali, B.O. Annuar and S.H. Inayat-Hussain, 2004. DNA damage evaluation of hydroxyapatite on fibroblast cell L929 using the single cell gel electrophoresis assay. Med. J. Malaysia, 59: 170-171.
    PubMed  |  
  70. Inayat-Hussain, S.H., N.F. Rajab, H. Roslie, A.A. Hussin, A.M. Ali and B.O. Annuar, 2004. Cell death induced by hydroxyapatite on L929 fibroblast cells. Med. J. Malaysia, 59: 176-177.
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  71. Annuar, B.O., M.H. Helme, A.M. Hasib, A.N. Rabihah and Z.S. Anum et al., 2004. Preliminary assessment of hydroxyapatite and tricalcium phosphate: In-vitro and In-vivo studies. Med. J. Malaysia, 59: 88-88.
  72. McKenna, D.J., N.F. Rajab, S.R. McKeown, G. McKerr and V.J. McKelvey-Martin, 2003. Use of the Comet-FISH assay to demonstrate repair of the TP53 gene region in two human bladder carcinoma cell lines. Radiat. Res., 159: 49-56.
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  73. Rajab, N.F. and V.J. McKelvey-Martin, 1999. Preferential rejoining of-radiation induced DNA strand breaks in the p53 domain of J82 bladder carcinoma cells. Mutagenesis, 14: 649-650.
  74. McKelvey-Martin, V.J., E.T. Ho, S.R. McKeown, S.R. Johnston, P.J. McCarthy, N.F. Rajab and C.S. Downes, 1998. Emerging applications of the single cell gel electrophoresis (Comet) assay. I. Management of invasive transitional cell human bladder carcinoma. II. Fluorescent in situ hybridization comets for the identification of damaged and repaired DNA sequences in individual cells. Mutagenesis, 13: 1-8.