Dr. Wahyu Widowati
My Social Links

Dr. Wahyu Widowati

Lecturer
Maranatha Christian University, Indonesia

Highest Degree
Ph.D. in Antioxidant Toxicology from Padjadjaran Univerisity, Indonesia

Share this Profile

Biography

Dr. Wahyu Widowati is an lecturer in Faculty of Medicine in Christian Maranatha University. She is also a researcher and a president of Biomolecular and Biomedical Research Center Aretha Medika Utama. She interests in cancer and stem cell for cancer therapy. Recent publications inculde a paper on the Biomarkers and Genomic Medicine for Wharton`s jelly-derived mesenchymal stem cells. After finished her study in toxicology, Dr. Wahyu Widowati is now pursuing Ph. D in medical degree and doing his dissertation in developing MSC and its derivative for cancer treatment.

Area of Interest:

Biomedical Sciences
100%
Toxicology
62%
Biomedical Research
90%
Antioxidants
75%
Antidiabetics
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
0
Abstracts
0

Selected Publications

  1. Sandhiutami, D., N. Made, M. Moordiani, D. Ratih Laksmitawati, N. Fauziah, M. Maesaroh and W. Widowati, 2017. In vitro assesment of anti-inflammatory activities of coumarin and Indonesian cassia extract in RAW264. 7 murine macrophage cell line. Iran. J. Basic Med. Sci., 20: 99-106.
    Direct Link  |  
  2. Luyen, B.T.T., N.P. Thao, W. Widowati, N. Fauziah, M. Maesaroh, T. Herlina and Y.H. Kim, 2017. Chemical constituents of Piper aduncum and their inhibitory effects on soluble epoxide hydrolase and tyrosinase. Med. Chem. Res., 26: 220-226.
    CrossRef  |  Direct Link  |  
  3. Laksmitawati, D.R., A. Widyastuti, N. Karami, E. Afifah, D.D. Rihibiha, H. Nufus and W. Widowati, 2017. Anti-inflammatory effects of Anredera cordifolia and Piper crocatum extracts on lipopolysaccharide-stimulated macrophage cell line. Bangladesh J. Pharmacol., 12: 1-6.
  4. Widowati, Wahyu, N. Fauziah, H. Herdiman, M. Afni, E. Afifah, H.S.W. Kusuma, H. Nufus, S. Arumwardana and D.D. Rihibiha, 2016. Antioxidant and Anti Aging Assays of Oryza sativa Extracts, Vanillin and Coumaric Acid. J. Nat. Remedies, 16: 88-99.
    Direct Link  |  
  5. Widowati, W., L. Wijaya, D.R. Laksmitawati, R.M. Widyanto, P.P. Erawijantari, N. Fauziah, I. Bachtiar and F. Sandra, 2016. Tea Flavonoids Protect Endothelial Progenitor Cells (EPCs) from Oxidative Damage by Reducing Reactive Oxygen Species (ROS) Level. Nat. Prod. Sci., 22: 87-92.
  6. Widowati, W., L. Wijaya, D.R. Laksmitawati, R.M. Widyanto and P.P. Erawijantari et al., 2016. Tea flavonoids induced differentiation of peripheral blood-derived mononuclear cells into peripheral blood-derived endothelial progenitor cells and suppressed intracellular reactive oxygen species level of peripheral blood-derived endothelial progenitor cells. Nat. Prod. Sci., 22: 87-92.
    CrossRef  |  Direct Link  |  
  7. Widowati, W., L. Darsono, J. Suherman, N. Fauziah, M. Maesaroh and P.P. Erawijantari, 2016. Anti-inflammatory effect of mangosteen (Garcinia mangostana L.) peel extract and its compounds in LPS-induced RAW264. 7 cells. Nat. Prod. Sci., 22: 147-153.
    CrossRef  |  Direct Link  |  
  8. Widowati, W., H. Murti, D.K. Jasaputra, S.B. Sumitro, M.A. Widodo, N. Fauziah, M. Maesaroh and I. Bachtiar, 2016. Selective cvytotoxic potential of IFN-γ and TNF-α on breast cancer cell lines (T47D and MCF7). Asian J. Cell Biol., 11: 1-12.
    CrossRef  |  Direct Link  |  
  9. Thao, N.P., B.T.T. Luyen, W. Widowati, N. Fauziah and M. Maesaroh, et al., 2016. Anti-inflammatory flavonoid C-glycosides from Piper aduncum leaves. Planta Med., 82: 1475-1481.
  10. Novilla, A., D.S. Djamhuri, N. Fauziah, M. Maesaroh, B. Balqis and W. Widowati, 2016. Cytotoxic Activity of Mangosteen (Garcinia mangostana L.) Peel Extract and α-mangostin toward Leukemia Cell Lines (HL-60 and K-562). J. Nat. Remedies, 16: 52-59.
    CrossRef  |  Direct Link  |  
  11. Laksmitawati, D.R., A.P. Prasanti, N. Larasinta, G.A. Syauta and R. Hilda, et al., 2016. Anti-Inflammatory Potential of Gandarusa (Gendarussa vulgaris Nees) and Soursoup (Annona muricata L) Extracts in LPS Stimulated-Macrophage Cell (RAW264. 7). J. Nat. Remedies, 16: 73-81.
    CrossRef  |  Direct Link  |  
  12. Hidayat, M., S. Prahastuti, N. Fauziah, M. Maesaroh, B. Balqis and W. Widowati, 2016. Modulation of adipogenesis-related gene expression by ethanol extracts of Detam 1 soybean and Jati belanda leaf in 3T3-L1 cells. Bangladesh J. Pharmacol., 11: 697-702.
    Direct Link  |  
  13. Widowati, W., T. Herlina, H. Ratnawati, G. Constantia, I.D.G.S. Deva and M. Maesaroh, 2015. Antioxidant potential of black, green and oolong tea methanol extracts. Biol. Med. Nat. Prod. Chem., 4: 35-39.
    CrossRef  |  Direct Link  |  
  14. Widowati, W., R.M. Widyanto, D.R. Laksmitawati, P.P. Erawijantari, L. Wijaya and F. Sandra, 2015. Phytochemical, Free Radical Scavenging and Cytotoxic Assay of Cucumis melo L. Extract and β-Carotene. J. Adv. Agric. Technol., 2: 114-119.
    Direct Link  |  
  15. Widowati, W., M. Maesaroh, N. Fauziah, P.P. Erawijantari and F. Sandra, 2015. Free radical scavenging and α-/β-glucosidase inhibitory activities of Rambutan (Nephelium lappaceum L.) peel extract. Indonesian Biomed. J., 7: 157-162.
    Direct Link  |  
  16. Widowati, W., L. Wijaya, H. Murti, H. Widyastuti and D. Agustina et al., 2015. Conditioned medium from normoxia (WJMSCs-norCM) and hypoxia-treated WJMSCs (WJMSCs-hypoCM) in inhibiting cancer cell proliferation. Biomarkers Genomic Med., 7: 8-17.
    CrossRef  |  Direct Link  |  
  17. Widowati, W., L. Wijaya, D. Agustina, H. Murti and N. Fauziah et al., 2015. Tumoricidal Property of Normoxia and Hypoxia Cell-Free Lysate of Wharton's Jelly-Mesenchymal Stem Cells Toward Various Cancer Cells. Int. J. Cancer Res., 11: 186-196.
  18. Widowati, W., H. Ratnawati, W. Husin and M. Maesaroh, 2015. Antioxidant properties of spice extracts. Biomed. Eng., 1: 24-29.
    Direct Link  |  
  19. Widowati, W., D.K. Jasaputra, S.B. Sumitrob, M.A. Widodo, K. Yaprianto and I. Bachtiar, 2015. Potential of Unengineered and Engineered Wharton's Jelly Mesenchymal Stem Cells as Cancer Inhibitor Agent. Immun. Endoc. Metab. Agents Med. Chem., 15: 128-137.
    Direct Link  |  
  20. Soeng, S., E. Evacuasiany, W. Widowati, N. Fauziah, V.T. Manik and M. Maesaroh, 2015. Inhibitory potential of rambutan seeds extract and fractions on adipogenesis in 3T3-L1 cell line. J. Exp. Integr. Med., 5: 55-60.
    CrossRef  |  Direct Link  |  
  21. Soeng, S., E. Evacuasiany, W. Widowati and N. Fauziah, 2015. Antioxidant and hypoglycemic activities of extract and fractions of Rambutan seeds (Nephelium lappaceum L.). Biomed. Eng., 1: 13-18.
    Direct Link  |  
  22. Rusmana, D., M. Elisabeth, W. Widowati, N. Fauziah and M. Maesa, 2015. Inhibition of Inflammatory Agent Production by Ethanol Extract and Eugenol of Syzygium aromaticum (L.) Flower Bud (Clove) in LPS-Stimulated Raw 264.7 Cells. Res. J. Med. Plant, 9: 264-274.
  23. Rahardja, F., R. Tjokropranoto, W. Widowati, S. Lusiana and A. Suhendra et al., 2015. Phytochemical assay, potential of antimalarial and antioxidant activities of green tea extract and its fraction. Biomed. Eng., 1: 1-7.
    Direct Link  |  
  24. Nurhayati, B., M.S. Wibowo, Y. Widyastuti, P.P. Erawijantari, W. Widowati, M.R.F. Pratama and T.G. Kartawinata, 2015. In silico analysis of plantaricin EF that expressed by plasmid-associated bacteriocin production gene of Lactobacillus plantarum IBL-2 for anti-candida agent potential. Res. J. Microbiol., 10: 582-591.
    CrossRef  |  Direct Link  |  
  25. Dewi, K., B. Widyarto, P.P. Erawijantari and W. Widowati, 2015. In vitro study of Myristica fragrans seed (Nutmeg) ethanolic extract and quercetin compound as anti-inflammatory agent. Int. J. Res. Med. Sci., 3: 2303-2310.
    Direct Link  |  
  26. Darsono, L., M. Hidayat, M. Maesaroh, N. Fauziah and W. Widowati, 2015. Ex Vivo Study Of Garcinia Mangostana L. (Mangosteen) Peel Extract and Xanthones as Anti-Adipogenesisin HepG2 Cell Model. Int. J. Med. Res. Health Sci., 4: 566-571.
  27. Budiman, I., R. Tjokropranoto, W. Widowati, N. Fauziah and P.P. Erawijantari, 2015. Potency of turmeric (Curcuma longa L.) extract and curcumin as anti-obesity by inhibiting the cholesterol and triglycerides synthesis in HepG2 cells. Int. J. Med. Res. Health Sci., 3: 1165-1171.
    CrossRef  |  Direct Link  |  
  28. Antoninus, A.A., W. Widowati, L. Wijaya, D.Agustina and S. Puradisastra et al., 2015. Human platelet lysate enhances the proliferation of Wharton's jelly-derived mesenchymal stem cells. Biomarkers Genomic Med., 7: 87-97.
    CrossRef  |  Direct Link  |  
  29. Afrianti, L.H., W.P. Widjaja, N. Suliasih, W. Widowati, N. Fauziah, M. Maesaroh and P.P. Erawijantari, 2015. Anticancer Activity of 3-Hydroxystigmastan- 5(6)-en (β-Sitosterol) Compound from Salacca Edulis Reinw Variety Bongkok in MCF-7 and T47D Cell Line. J.Adv. Agric. Technol., 2: 129-133.
    Direct Link  |  
  30. Widowati, W., R.M. Widyanto, W. Husin, H. Ratnawati and D.R. Laksmitawati et al., 2014. Green tea extract protects endothelial progenitor cells from oxidative insult through reduction of intracellular reactive oxygen species activity. Iran. J. Basic Med. Sci., 17: 702-709.
  31. Widowati, W., L. Darsono, J. Suherman, Y. Yelliantty and M. Maesaroh, 2014. High Performance Liquid Chromatography (HPLC) Analysis, Antioxidant, Antiaggregation of Mangosteen Peel Extract (Garcinia mangostana L.). Int. J. Biosci Biochem. Bioinf., 4: 458-466.
    Direct Link  |  
  32. Widowati, W., H. Ratnawati, R. Wahyudianingsih, Y. Yelliantty, M. Maesaroh, D. Pujimulyani and T. Mozef, 2014. Effect of green tea extract and epigallocatechin-3-gallate potency on lipid profile and coronary artery morphology of dyslipidemic rats. Oxid. Antioxid. Med. Sci., 3: 147-152.
    CrossRef  |  Direct Link  |  
  33. Widowati, W., C.T. Sardjono, L. Wijaya, D.R. Laksmitawati, J.A. Pawitan and F. Sandra, 2014. Effect of a-carotene on cell proliferation and differentiation of adipose-derived stem cells into endothelial progenitor cells. BTAIJ, 9: 407-412.
  34. Novilla, A., A. Nawawi, G. Sugihartina and W. Widowati, 2014. Antioxidative and Antibacterial Activities of Indonesian Propolis Extracts against Methicillin-Resistant Staphylococcus aureus (MRSA) in Vitro. Cukurova Med. J., 39: 224-233.
    Direct Link  |  
  35. Evacuasiany, E.,H. Ratnawati, L.K. Liana, W. Widowati, M. Maesaroh, T. Mozef and C. Risdian, 2014. Cytotoxic and antioxidant activities of catechins in inhibiting the malignancy of breast cancer. J. Exp. Integr. Med., 3: 141-146.
    CrossRef  |  
  36. Widowati, W., L. Wijajya, T.L.W. Setia and Y. Yelliantty, 2013. Antioxidant, anticancer, and apoptosis-inducingeffects of Piper extracts in HeLa cells. J. Exp. Integr. Med., 3: 225-230.
  37. Widowati, W., H. Ratnawati, T. Mozef, D. Pujimulyani and Y. Yelliantty, 2013. Hypolipidemic And Antioxidant Effects of Black Tea Extract and Quercetin in Atherosclerotic Rats. Int. J. Med. Sci. Eng., 7: 153-160.
    Direct Link  |  
  38. Widowati, W. and R.M. Widiyanto, 2013. Stem Cell as Alternative Therapy. Zenit, J. Ilmiah Universitas Kristen Maranatha, 2: 1-5.
  39. Tjahjani, S. and W. Widowati, 2013. Potency Xanthones as Antioxidant and Antimalarial and Synergism with Artemesinin. Majalah Kedokteran Indonesia, 63: 95-99.
  40. Widowati, W., C.T. Sardjono, L. Wijaya, D.R. Laksmitawati and F. Sandra, 2012. Extract of Curcuma longa L. and (-)-epigallo catechin-3-gallate enhanced proliferation of adipose tissue-derived mesenchymal stem cells (AD-MSCs) and differentiation of AD-MSCs into endothelial progenitor cells. J. US-China Med. Sci., 9: 22-29.
    Direct Link  |  
  41. Widowati, W., T.H.H. Ratnawati and T. Mozef, 2011. Antioxidant activities and platelet aggregation inhibitor of black tea (Camellia sinensis L.) extract and fractions. Med. Plants, 3: 21-26.
  42. Widowati, W., H. Ratnawati, F.F. Sandra and T. Mozef, 2011. Inhibitor properties of Piper betle L., Catharanthus roseus [L.] G.Don, Dendrophtoe petandra L., curcuma mangga val. extracts on T47D cancer cell line. Int. Res. J. Biochem. Bioinf., 1: 22-28.
  43. Widowati, W., H. Ratnawati and U.D. Rusdi, 2011. The antiplatelet aggregation effect of extract and ethyl acetate fraction of velvet bean seed (Mucuna pruriens L.) in dyslipidemic rat. Agritech J. Teknologi Pangan, 31: 52-59.
    Direct Link  |  
  44. Widowati, W., H. Ratnawati and C. Retnaningsih, 2011. Free radical Scavening and α-Glucosidase Inhibitor Activity. Of Ethanolic Extract of Mucuna pruriens L. J. Majalah Farmasi, 5: 117-124.
    Direct Link  |  
  45. Ratnawati, H. and W. Widowati, 2011. Hubungan antara Kadar Karbon Monoksida (CO) Udara dan Tingkat Kewaspadaan Petugas Parkir di Tiga Jenis Tempat Parkir. Jurnal Kedokteran Maranatha, 10: 1-9.
    Direct Link  |  
  46. Ratnawati, H. and W. Widowati, 2011. Anticholesterol Activity of Velvet Bean (Mucuna pruriens L.) Towards Hypercholesterolemic Rats. Sains Malaysiana, 40: 323-327.
  47. Widowati, W., H. Ratnawati, F.F. Sandra and M. Tjandrawati, 2010. Apoptosis and antioxidant activities of Catharanthus roseus [L.] G. don extrcat on breast cancer cell line. Indonesian J. Cancer Chemoprev., 1: 99-107.
  48. Widowati, W., H. Ratnawati and U.D. Rusdi, 2010. Phytochemical assay and antiplatelet activity of fractions of velvet bean seeds (Mucuna pruriens L.). Hayati J. Biosci., 17: 85-90.
    Direct Link  |  
  49. Risdian, C., W. Widowati, T.L. Wargasetia and K. Khiong, 2010. Free radical sacvenging activity of ethanolic leaves extract and its different solvent. Indonesian J. Cancer Chemoprev., 2: 141-145.
  50. Ratnawati, H. and W. Widowati, 2010. The effect of ethyl acetate and butanol fractions of velvet bean seed (Mucuna pruriens L.) to improve lipid profile in dyslipidemic rats. J. Medika Planta, 1: 36-42.
    Direct Link  |  
  51. Agnes, C.S. and W. Widowati, 2010. Glisodin improve stem cells Cermin Dunia Kedokteran, 37: 107-110.
  52. Widowati, W., 2007. Antioxidant as hypocholesterolemic inhibit lipid peroxidation and atherosclerosis. Majalah Kedokteran, 6: 12-17.