Dr. Yanguo Hong
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Dr. Yanguo Hong

Professor
Fujian Normal University, China

Highest Degree
Ph.D. in Physiology from McGill University, Canada

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Area of Interest:

Biomedical Sciences
100%
Physiology Immunology
62%
Physiological Mechanisms
90%
Cellular Biochemistry
75%
Physical Biochemistry
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
0
Abstracts
0

Selected Publications

  1. Zhang, Y., K. Wang, M. Lin, Q. Li and Y. Hong, 2017. Inhibition of morphine tolerance by Mrgc receptor via modulation of interleukin-1β and matrix metalloproteinase 9 in dorsal root ganglia in rats. Eur. J. Pharmacol., 815: 10-17.
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  2. Chen, Y.J., Y.H. Huo and Y. Hong, 2017. [Effects of intrathecal administration of AM22-52 on mechanical allodynia and CCL2 expression in DRG in bone cancer rats]. Sheng Li Xue Bao, 69: 70-76.
  3. Wang, D., Y. Xue, Y. Yan, M. Lin, J. Yang, J. Huang and Y. Hong, 2016. Reversal of neurochemical alterations in the spinal dorsal horn and dorsal root ganglia by Mas-related gene (Mrg) receptors in a rat model of spinal nerve injury. Neurobiol. Dis., 91: 274-283.
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  4. Wang, D., Y. Xue, Y. Chen, L. Ruan and Y. Hong, 2016. Mas-related gene (Mrg) C receptors inhibit mechanical allodynia and spinal microglia activation in the early phase of neuropathic pain in rats. Neurosci. Lett., 618: 115-121.
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  5. Wang, D., J. Zeng, Q. Li, J. Huang, R. Couture and Y. Hong, 2016. Contribution of adrenomedullin to the switch of G protein-coupled μ-opioid receptors from Gi to Gs in the spinal dorsal horn following chronic morphine exposure in rats. Br. J. Pharmacol., 173: 1196-1207.
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  6. Huang, J., J. Wu, H.Z. Yang and Y. Hong, 2016. Inhibition of prostaglandins synthesis in the inflamed site results in opioid-mediated hypoalgesia in rats. Sheng Li Xue Bao, 68: 241-248.
  7. Hu, W., Y. Zhang, Q. Cai, D. Wang and Y. Hong, 2016. Blockade of 5-HT2A receptors at the site of inflammation inhibits activation of spinal dorsal horn neurons in rats. Brain Res. Bull., 124: 85-94.
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  8. Chen, Y., Y. Zhang, Y. Huo, D. Wang and Y. Hong, 2016. Adrenomedullin mediates tumor necrosis factor-α-induced responses in dorsal root ganglia in rats. Brain Res., 1644: 183-191.
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  9. Wang, D., P. Wang, J. Jiang, Q. Lv, X. Zeng and Y. Hong, 2015. Activation of Mas oncogene-related g protein-coupled receptors inhibits neurochemical alterations in the spinal dorsal horn and dorsal root ganglia associated with inflammatory pain in rats. J. Pharmacol. Exp. Ther., 35: 431-439.
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  10. Zeng, X., M.Y. Lin, D. Wang, Y. Zhang and Y. Hong, 2014. Involvement of adrenomedullin in spinal glial activation following chronic administration of morphine in rats. Eur. J. Pain, 18: 1323-1332.
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  11. Wang, D., Y. Huo, R. Quirion and Y. Hong, 2014. Involvement of adrenomedullin in the attenuation of acute morphine-induced analgesia in rats. Peptides, 54: 67-70.
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  12. Wang, D., R. Couture and Y. Hong, 2014. Activated microglia in the spinal cord underlies diabetic neuropathic pain. Eur. J. Pharmacol., 728: 59-66.
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  13. Wang, D., J. Li, P. Chen and Y. Hong, 2014. Upregulation of pronociceptive mediators and downregulation of opioid peptide by adrenomedullin following chronic exposure to morphine in rats. Neuroscience, 280: 31-39.
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  14. Huang, H., Q. Li, Y. Hong and D. Wang, 2014. MrgC receptor activation reverses chronic morphine-evoked alterations of glutamate transporters and nNOS in rats. Sheng Li Xue Bao, 66: 449-456.
  15. Wang, D., X. Zhou and Y. Hong, 2013. Effects of a combination of ketanserin and propranolol on inflammatory hyperalgesia in rats. Eur. J. Pharmacol., 721: 126-132.
  16. Wang, D., T. Chen, X. Zhou, R. Couture and Y. Hong, 2013. Activation of Mas oncogene-related gene (Mrg) C receptors enhances morphine-induced analgesia through modulation of coupling of μ-opioid receptor to Gi-protein in rat spinal dorsal horn. Neuroscience, 253: 455-464.
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  17. Wang, D., L. Ruan, Y. Hong, J.G. Chabot and R. Quirion, 2013. Involvement of PKA-dependent upregulation of nNOS-CGRP in adrenomedullin-initiated mechanistic pathway underlying CFA-induced response in rats. Exp. Neurol., 239: 111-119.
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  18. Jiang, J., D. Wang, X. Zhou, Y. Huo and T. Chen et al., 2013. Effect of Mas-related gene (Mrg) receptors on hyperalgesia in rats with CFA-induced inflammation via direct and indirect mechanisms. Br. J. Pharmacol., 170: 1027-1040.
  19. Wang, D., T. Chen, Y. Gao, R. Quirion and Y. Hong, 2012. Inhibition of SNL-induced upregulation of CGRP and NPY in the spinal cord and dorsal root ganglia by the 5-HT2A receptor antagonist ketanserin in rats. Pharmacol. Biochem. Behav., 101: 379-386.
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  20. Hong, Y., D.L. Hay, R. Quirion and D.R. Poyner, 2012. The pharmacology of Adrenomedullin 2/Intermedin. Br. J. Pharmacol., 166: 110-120.
  21. Chen, T., J. Jiang, D. Wang, Y. Liu and Y. Hong, 2012. Role of bovine adrenal medulla 22 (BAM22) in the pathogenesis of neuropathic pain in rats with spinal nerve ligation. Eur. J. Pharmacol., 685: 24-29.
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  22. Chen, T., D. Wang and Y. Hong, 2012. Dual modulation effects of Mas-related gene (Mrg) receptors on pain sensitivity in rats. Neurosci. Lett., 514: 82-85.
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  23. Wang, D., P. Chen, Q. Li, R. Quirion and Y. Hong, 2011. Blockade of adrenomedullin receptors reverses morphine tolerance and its neurochemical mechanisms. Behav. Brain Res., 221: 83-90.
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  24. Jiang, J. and Y. Hong, 2011. Bovine adrenal medulla 22 attenuates hyperalgesia in the early phase of complete Freund’s adjuvant-induced inflammation in rats. Sheng Li Xue Bao, 63: 529-535.
  25. Huang, J., Y. Fan, Y. Jia and Y. Hong, 2011. Antagonism of 5-HT2A receptors inhibits the expression of pronociceptive mediator and enhances endogenous opioid mechanism in carrageenan-induced inflammation in rats. Eur. J. Pharmacol., 654: 33-41.
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  26. Wang, D., Y. Gao, H. Ji and Y. Hong, 2010. Topical and systemic administrations of ketanserin attenuate hypersensitivity and expression of CGRP in rats with spinal nerve ligation. Eur. J. Pharmacol., 627: 124-130.
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  27. Hong, Y., D. Wang, J.G. Chabot, W. Ma, P. Chen and R. Quirion, 2010. A role for protein kinase C-dependent upregulation of adrenomedullin in the development of morphine tolerance in male rats. J. Neurosci., 30: 12508-12516.
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  28. Dai, F. and Y. Hong, 2010. The Mrg family and pain. Prog. Biochem. Biophys., 37: 467-474.
  29. Chen, P., D. Wang, M. Li, Y. Zhang, R. Quirion and Y. Hong, 2010. Modulation of sensory neuron-specific receptors in the development of morphine tolerance and its neurochemical mechanisms. J. Neurosci. Res., 88: 2952-2963.
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  30. Huang, J., Q. Cai, Y. Chen and Y. Hong, 2009. Treatment with ketanserin produces opioid-mediated hypoalgesia in the late phase of carrageenan-induced inflammatory hyperalgesia in rats. Brain Res., 1303: 39-47.
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  31. Hong, Y., Y. Liu, J.G. Chabot, A. Fournier and R. Quirion, 2009. Upregulation of adrenomedullin in the spinal cord and dorsal root ganglia in the early phase of CFA-induced inflammation in rats. Pain, 146: 105-113.
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  32. Huang, H., Q. Cai, W. Lin and Y. Hong, 2008. Effects of blockade of 5-HT2A receptors in the inflamed site on the expression of nitric oxide synthase in the spinal cord of rats. J. Chinese Pain Med., 14: 96-100.
  33. Chen, T., Z. Hu, R. Quirion and Y. Hong, 2008. Modulation of NMDA receptors by intrathecal sensory neuron-specific receptor agonist BAM8-22. Neuropharmacology, 54: 796-803.
  34. Chen, P., Y. Liu and Y. Hong, 2008. Effect of chronic administration of morphine on the expression of bovine adrenal medulla 22-like immunoreactivity in the spinal cord of rats. Eur. J. Pharmacol., 589: 110-113.
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  35. Li, Q. and Y. Hong, 2007. The role of nitric oxide in inflammatory pain. Life Sci., 4: 423-426.
  36. Jiang, J. and Y. Hong, 2007. Effect of bovine adrenal medulla 22 on expression of noxious stimulus-evoked c-Fos in the spinal dorsal horn in morphine tolerant rats. J. Chinese Pain Med., 13: 166-170.
  37. Ji, H. and Y. Hong, 2007. 5-HT2A receptors and pain. Int. J. Pathol. Clin. Med., 27: 56-61.
  38. Hu, Z. and Y. Hong, 2007. Protein kinase C and pain. J. Neuroanat., 23: 436-440.
  39. Cai, Q., J. Jiang, T. Chen and Y. Hong, 2007. Sensory neuron-specific receptor agonist BAM8-22 inhibits the development and expression of tolerance to morphine in rats. Behav. Brain Res., 178: 154-159.
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  40. Cai, M., T. Chen, R. Quirion and Y. Hong, 2007. The involvement of spinal bovine adrenal medulla 22-like peptide, the proenkephalin derivative, in modulation of nociceptive processing. Eur. J. Neurosci., 26: 1128-1138.
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  41. Jiang, J., Y. Chen and Y. Hong, 2006. Differential reversal effect of intrathecal bovine adrenal medulla peptide 22 on morphine tolerance in rats. Sheng Li Xue Bao, 58: 529-535.
  42. Jiang, J., J. Huang and Y. Hong, 2006. Bovine adrenal medulla 22 reverses antinociceptive morphine tolerance in the rat. Behav. Brain Res., 168: 167-171.
  43. Hong, Y., H. Ji and H. Wei, 2006. Topical ketanserin attenuates hyperalgesia and inflammation in arthritis in rats. Pain, 124: 27-33.
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  44. Chen, X., F. Bing, P. Dai and Y. Hong, 2006. Involvement of protein kinase C in 5-HT-evoked thermal hyperalgesia and spinal fos protein expression in the rat. Pharmacol. Biochem. Behav., 84: 8-16.
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  45. Chen, T., Q. Cai and Y. Hong, 2006. Intrathecal sensory neuron-specific receptor agonists BAM8-22 and (Tyr6)-γ2-MSH-6-12 inhibit formalin-evoked nociception and neuronal Fos-like immunoreactivity in the spinal cord of the rat. Neuroscience, 141: 965-975.
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  46. Cai, M. and Y. Hong, 2006. Advance in the study of BAM22. Chinese Clin. Pharmacol. Ther., 11: 1-5.
  47. Zeng, X., Y. Lin and Y. Hong, 2005. c-Fos expression in spinal dorsal horn of rats. J. Fujian Normal Univ. (Nat. Sci.), 21: 95-98.
  48. Wei, H., Y. Chen and Y. Hong, 2005. The contribution of peripheral 5-hydroxytryptamine2A receptor to carrageenan-evoked hyperalgesia, inflammation and spinal Fos protein expression in the rat. Neuroscience, 132: 1073-1082.
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  49. Zeng, X., H. Huang and Y. Hong, 2004. Effects of intrathecal BAM22 on noxious stimulus-evoked c-fos expression in the rat spinal dorsal horn. Brain Res., 1028: 170-179.
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  50. Hong, Y., P. Dai, J. Jiang and X. Zeng, 2004. Dual effects of intrathecal BAM22 on nociceptive responses in acute and persistent pain-potential function of a novel receptor. Br. J. Pharmacol., 141: 423-430.
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  51. Zhang, Y., Y. Hong, Y. Bounhar, M. Blacker and X. Roucou et al., 2003. p75 neurotrophin receptor protects primary cultures of human neurons against extracellular amyloid β peptide cytotoxicity. J. Neurosci., 23: 7385-7394.
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  52. Cao, C.Q., Y.G. Hong, A. Dray and M.N. Perkins, 2001. Selective depression of nociceptive responses of dorsal horn neurones by SNC 80 in a perfused hindquarter preparation of adult mouse. Neuroscience, 107: 329-338.
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  53. Cao, C.Q., Y. Hong, A. Dray and M. Perkins, 2001. Spinal δ-opioid receptors mediate suppression of systemic SNC80 on excitability of the flexor reflex in normal and inflamed rat. Eur. J. Pharmacol., 418: 79-87.
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  54. Kenigsberg, R.L., Y. Hong and Y. Theoret, 1998. Cholinergic cell expression in the developing rat medial septal nucleus in vitro is differentially controlled by GABAA and GABAB receptors. Brain Res., 805: 123-130.
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  55. Kenigsberg, R.L., Y. Hong, H. Yao, N. Lemieux, J. Michaud, C. Tautu and Y. Theoret, 1997. Effects of basic fibroblast growth factor on the differentiation, growth, and viability of a new human medulloblastoma cell line (UM-MB1). Am. J. Pathol., 151: 867-881.
  56. Abbott, F.V., Y. Hong and P. Blier, 1997. Persisting sensitization to pain through activation of 5-HT2A receptors. Neuroscience, 77: 575-584.
  57. Hong, Y. and F.V. Abbott, 1996. Contribution of peripheral α1A-adrenoceptors to pain induced by formalin or by α-methyl-5-hydroxytryptamine plus noradrenaline. Eur. J. Pharmacol., 301: 41-48.
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  58. Abbott, F.V., Y. Hong and P. Blier, 1996. Activation of 5-HT2A receptors potentiates pain produced by inflammatory mediators. Neuropharmacology, 35: 99-110.
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  59. Abbott, F.V., Y. Hong and K.B.J. Franklin, 1996. The effect of lesions of the dorsolateral funiculus on formalin pain and morphine analgesia: A dose-response analysis. Pain, 65: 17-23.
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  60. Hong, Y. and F.V. Abbott, 1995. Peripheral opioid modulation of pain and inflammation in the formalin test. Eur. J. Pharmacol., 277: 21-28.
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  61. Hong, Y., D.F. Cechetto and L.C. Weaver, 1994. Spinal cord regulation of sympathetic activity in intact and spinal rats. Am. J. Physiol., 266: H1485-H1493.
  62. Hong, Y. and A.V. Abbott, 1994. Behavioral effects of intra-plantar injection of inflammatory mediators in the rat. Neuroscience, 63: 827-836.
  63. Hong, Y. and L.C. Weaver, 1993. Distribution of enkephalin-,substance P- and vasoactive intestinal peptide-like immunoreactivities in autonomic nuclei of middle and lower thoracic spinal cord of rat: Relationship with sympathetic preganglionic neurons contributing to the greater splanchnic nerve. Neuroscience, 57: 1121-1133.
  64. Hong, Y. and J.L. Henry, 1992. NMDA receptor antagonists block cardiovascular responses to intrathecal administration of D-baclofen in the rat. Eur. J. Pharmacol., 216: 257-263.
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  65. Hong, Y. and J.L. Henry, 1992. Intrathecal administration of non-NMDA receptor agonists increases arterial pressure and heart rate in the rat. Brain Res., 591: 62-68.
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  66. Hong, Y. and J.L. Henry, 1992. Glutamate, NMDA and NMDA receptor antagonists: Cardiovascular effects of intrathecal administration in the rat. Brain Res., 569: 38-45.
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  67. Hong, Y. and J.L. Henry, 1991. Phaclofen-reversible effects of GABA in the spinal cord of the rat. Eur. J. Pharmacol., 201: 171-177.
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  68. Hong, Y. and J.L. Henry, 1991. Effects of phaclofen and the enantiomers of baclofen on cardiovascular responses to intrathecal administration of L-and D-baclofen in the rat. Eur. J. Pharmacol., 196: 267-275.
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  69. Hong, Y. and J.L. Henry, 1991. Cardiovascular responses to intrathecal administration of L-and D-baclofen in the rat. Eur. J. Pharmacol., 192: 55-62.
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  70. Hong, Y. and J.L. Henry, 1990. Spinal mediation of the increases in arterial pressure and heart rate in response to intrathecal administration of bicuculline. Brain Res., 513: 86-93.
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  71. Hong, Y., K. Yashpal and J.L. Henry, 1989. Cardiovascular responses to intrathecal administration of strychnine in the rat. Brain Res., 499: 169-173.
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  72. Hong, Y. and K. Krnjevic, 1989. Serotonin blocks the facilitatory action of muscarinic and nicotinic agents in the hippocampus in vivo. Can. J. Physiol. Pharmacol., 67: 47-53.
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  73. Deng, L., Y. Hong and G. Li, 1985. The experimental study on phasic conduction block. Chinese J. Cardiol., 12: 137-142.
  74. Hong, Y.G., T.L. Dai, Q.Z. Zang and Z.Z. Lu, 1983. Effect of stimulation of somatosensory cortex on nociceptive discharges of parafascicular neurons in rabbit's thalamus. Acta Physiol. Sin., 32: 156-162.
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