Dr. Li Wei
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Dr. Li Wei

Research Scientist
Jilin University, China

Highest Degree
Ph.D. in Pharmacology from Jilin Agricultural University, China

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Area of Interest:

Pharmacology and Toxicology
100%
Traditional Chinese Medicine
62%
Biological Activities
90%
Medicinal Plants
75%
Process Control
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
73
Abstracts
0

Selected Publications

  1. Zhou, Y.D., J.G. Hou, G. Yang, S. Jiang and C. Chen et al., 2019. Icariin ameliorates cisplatin-induced cytotoxicity in human embryonic kidney 293 cells by suppressing ROS-mediated PI3K/Akt pathway. Biomed. Pharm., 109: 2309-2317.
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  2. Zeng, Q., L. Wei, T. Jing, W. Cui-zhu, L. Hongqiang, Z. Baisong and L. Jinping, 2019. Effect of ginsenoside Rh2 on renal apoptosis in cisplatin-induced nephrotoxicity in vivo. Phytomedicine, Vol. 61. 10.1016/j.phymed.2019.152862.
    CrossRef  |  Direct Link  |  
  3. Xing, J.J., J.G. Hou, Z.N. Ma, Z. Wang and S. Ren et al., 2019. Ginsenoside Rb3 provides protective effects against cisplatin-induced nephrotoxicity via regulation of AMPK-/mTOR-mediated autophagy and inhibition of apoptosis in vitro and in vivo. Cell Proliferation, Vol. 52. 10.1111/cpr.12627.
    CrossRef  |  Direct Link  |  
  4. Xin, S.Q., Z. Wang, W.N. Hao, X.T. Yan and Q. Xu et al., 2019. Liver protection effect of steamed codonopsis lanceolata on alcohol-induced liver injury in mice and its main components by LC/MS analysis. Int. J. Pharmacol., 15: 394-402.
    CrossRef  |  Direct Link  |  
  5. Mi, X.J., J.G. Hou, S. Jiang, Z. Liu and S. Tang et al., 2019. Maltol mitigates thioacetamide-induced liver fibrosis through TGF-β1-mediated activation of PI3K/Akt signaling pathway. J. Agric. Food Chem., 67: 1392-1401.
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  6. Li, R.Y., W.Z. Zhang, X.T. Yan, J.G. Hou and Z. Wang et al., 2019. Arginyl-fructosyl-glucose, a major maillard reaction product of red ginseng, attenuates cisplatin-induced acute kidney injury by regulating nuclear factor ΚB and phosphatidylinositol 3-kinase/protein kinase B signaling pathways. J. Agric. Food Chem., 67: 5754-5763.
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  7. Leng, J., J.G. Hou, C.L. Fu, S. Ren and S. Jiang et al., 2019. Platycodon grandiflorum saponins attenuate scrotal heat-induced spermatogenic damage via inhibition of oxidative stress and apoptosis in mice. J. Funct. Food, 54: 479-488.
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  8. Hu, J.N., X.Y. Xu, W. Li, Y.M. Wang, Y. Liu, Z. Wang and Y.P. Wang, 2019. Ginsenoside Rk1 ameliorates paracetamol-induced hepatotoxicity in mice through inhibition of inflammation, oxidative stress, nitrative stress and apoptosis. J. Ginseng Res., 43: 10-19.
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  9. Zhou, Y.D., J.G. Hou, W. Liu, S. Ren and Y.P. Wang et al., 2018. 20 (R)-ginsenoside Rg3, a rare saponin from red ginseng, ameliorates acetaminophen-induced hepatotoxicity by suppressing PI3K/AKT pathway-mediated inflammation and apoptosis. Int. Immunopharmacol., 59: 21-30.
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  10. Zhou, S., Y. Shao, J. Fu, L. Xiang, Y. Zheng and W. Li, 2018. Characterization and quantification of taxifolin related flavonoids in Larix olgensis Henry Var. koreana Nakai extract analysis and its antioxidant activity assay. Int. J. Pharmacol., 14: 534-545.
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  11. Zhao, L.C., Y. Liu, Z. Wang, N. Tang and J. Leng et al., 2018. Liquid chromatography/mass spectrometry analysis and hepatoprotective effect of steamed platycodi radix on acute alcohol-induced liver injury. Int. J. Pharmacol., 14: 952-962.
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  12. Zhang, W., J. Hou, X. Yan, J. Leng and R. Li et al., 2018. Platycodon grandiflorum saponins ameliorate cisplatin-induced acute nephrotoxicity through the NF-κB-mediated inflammation and PI3K/Akt/apoptosis signaling pathways. Nutrients, Vol. 10. 10.3390/nu10091328.
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  13. Yang, H., W. Li, L. Wang, X. He, H. Sun and J. Zhang, 2018. The proteins from Sika deer antler as potential modulators on cisplatin-induced cytotoxicity in human embryonic kidney 293 cells. Nat. Prod. Res., 32: 1982-1986.
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  14. Yang, G., Z. Wang, S. Ren, X.T. Yan and X.Y. Xu et al., 2018. Hepato-protective effect of ginsenosides from the fruits of panax ginseng against acetaminophen-induced liver damage in mice. Int. J. Pharmacol., 14: 1107-1117.
  15. Yan, X.T., Y.S. Sun, S. Ren, L.C. Zhao and W.C. Liu et al., 2018. Dietary α-mangostin provides protective effects against acetaminophen-induced hepatotoxicity in mice via Akt/mTOR-mediated inhibition of autophagy and apoptosis. Int. J. Mol. Sci., Vol. 19. 10.3390/ijms19051335.
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  16. Xu, X.Y., Z. Wang, S. Ren, J. Leng and J.N. Hu et al., 2018. Improved protective effects of American ginseng berry against acetaminophen-induced liver toxicity through TNF-α-mediated caspase-3/-8/-9 signaling pathways. Phytomedicine, 51: 128-138.
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  17. Wang, Z., Y.F. Li, X.Y. Han, Y.S. Sun and L.X. Zhang et al., 2018. Kidney protection effect of ginsenoside re and its underlying mechanisms on cisplatin-induced kidney injury. Cell. Physiol. Biochem., 48: 2219-2229.
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  18. Qi, Z., Z. Li, W. Li, Y. Liu and C. Wang, 2018. Pseudoginsengenin DQ exhibits therapeutic effects in cisplatin-induced acute kidney injury via sirt1/NF-κB and caspase signaling pathway without compromising its antitumor activity in mice. Molecules, Vol. 23. 10.3390/molecules23113038.
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  19. Mi, X.J., J.G. Hou, Z. Wang, Y. Han and S. Ren et al, 2018. The protective effects of maltol on cisplatin-induced nephrotoxicity through the AMPK-mediated PI3K/Akt and p53 signaling pathways. Sci. Rep., .
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  20. Liu, W., Z. Wang, J.G. Hou, Y.D. Zhou and Y.F. He et al., 2018. The liver protection effects of maltol, a flavoring agent, on carbon tetrachloride-induced acute liver injury in mice via inhibiting apoptosis and inflammatory response. Molecules, Vol. 23. 10.3390/molecules23092120.
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  21. Li, Y.Z., Z.N. Ma, Y.S. Sun, R. Shen and J. Shuang et al., 2018. Schisandra chinensis stems exerts potential protective effects on acetaminophen-induced hepatotoxicity via regulation of MAPK and caspase-3 signaling pathways. Chin. J. Nat. Med., 16: 700-713.
  22. Li, Y.Z., S. Ren, X.T. Yan, H.P. Li and W. Li et al., 2018. Improvement of Cisplatin-induced renal dysfunction by Schisandra chinensis stems via anti-inflammation and anti-apoptosis effects. J. Ethnopharmacol., 217: 228-237.
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  23. Li, W. and C. Chen, 2018. Response to the comments on caspase-mediated anti-apoptotic effect of ginsenoside Rg5, a main rare ginsenoside, on acetaminophen-induced hepatotoxicity in mice. J. Agric. Food Chem., 66: 1734-1735.
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  24. Leng, J., Z. Wang, C.L. Fu, J. Zhang and S. Ren et al., 2018. NF-κB and AMPK/PI3K/Akt signaling pathways are involved in the protective effects of Platycodon grandiflorum saponins against acetaminophen‐induced acute hepatotoxicity in mice. Phytother. Res., 32: 2235-2246.
    CrossRef  |  Direct Link  |  
  25. Leng, J., Z. Wang, C.L. Fu, J. Zhang and S. Ren et al., 2018. NF-κB and AMPK/PI3K/Akt signaling pathways are involved in the protective effects of Platycodon grandiflorum saponins against acetaminophen-induced acute hepatotoxicity in mice. Phytother., Res., 10.1002/ptr.6160.
    CrossRef  |  Direct Link  |  
  26. Hou, J., J. Xue, Z. Wang and W. Li, 2018. Ginsenoside Rg3 and Rh2 protect trimethyltin‐induced neurotoxicity via prevention on neuronal apoptosis and neuroinflammation. Phytother. Res., 32: 2531-2540.
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  27. Hou, J., J. Xue, X. Zhao, Z. Wang, W. Li, X. Li and Y. Zheng, 2018. Octyl ester of ginsenoside compound K as novel anti-hepatoma compound: Synthesis and evaluation on murine H22 cells in vitro and in vivo. Chem. Biol. Drug Des., 91: 951-956.
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  28. Fu, C.L., Y. Liu, J. Leng, J. Zhang and Y.F. He et al., 2018. Platycodin D protects acetaminophen-induced hepatotoxicity by inhibiting hepatocyte MAPK pathway and apoptosis in C57BL/6J mice. Biomed. Pharm., 107: 867-877.
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  29. Chen, B., Z. Liu, Y. Zhang, W. Li and Y. Sun et al., 2018. Application of high-speed counter-current chromatography and HPLC to separate and purify of three polyacetylenes from Platycodon grandiflorum. J. Sep. Sci., 41: 789-796.
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  30. Yang, H., W. Li, L. Wang, W. Li, H. Sun, X. He and J. Zhang, 2017. The protective effects of sika deer antler protein on cisplatin-induced nephrotoxicity. Cell. Physiol. Biochem., 43: 395-404.
    CrossRef  |  Direct Link  |  
  31. Xu, X.Y., J.N. Hu, Z. Liu, R. Zhang and Y.F. He et al., 2017. Saponins (Ginsenosides) from the Leaves of Panax quinquefolius ameliorated acetaminophen-induced hepatotoxicity in mice. J. Agric. Food Chem., 65: 3684-3692.
    CrossRef  |  Direct Link  |  
  32. Wang, Z., J.N. Hu, M.H. Yan, J.J. Xing, W.C. Liu and W. Li, 2017. Caspase-mediated anti-apoptotic effect of ginsenoside Rg5, a main rare ginsenoside, on acetaminophen-induced hepatotoxicity in mice. J. Agric. Food Chem., 65: 9226-9236.
    CrossRef  |  Direct Link  |  
  33. Qi, Z.L., Z. Wang, W. Li, J.G. Hou and Y. Liu et al., 2017. Nephroprotective effects of anthocyanin from the fruits of Panax ginseng (GFA) on cisplatin-induced acute kidney injury in mice. Phytother. Res., 31: 1400-1409.
    CrossRef  |  Direct Link  |  
  34. Meng, F., X. Su, W. Li and Y. Zheng, 2017. Ginsenoside Rb3 strengthens the hypoglycemic effect through AMPK for inhibition of hepatic gluconeogenesis. Exp. Ther. Med., 13: 2551-2557.
    CrossRef  |  Direct Link  |  
  35. Ma, Z.N., Z. Liu, Z. Wang, S. Ren and S. Tang et al., 2017. Supplementation of American ginseng berry extract mitigated cisplatin-evoked nephrotoxicity by suppressing ROS-mediated activation of MAPK and NF-κB signaling pathways. Food Chem. Toxicol., 110: 62-73.
    CrossRef  |  Direct Link  |  
  36. Ma, Z.N., Y.Z. Li, W. Li, X.T. Yan and G. Yang et al., 2017. Nephroprotective effects of saponins from leaves of Panax quinquefolius against cisplatin-induced acute kidney injury. Int. J. Mol. Sci., Vol. 18. 10.3390/ijms18071407.
    CrossRef  |  Direct Link  |  
  37. Liu, Z., C.Z. Wang, X.Y. Zhu, J.Y. Wan and J. Zhang et al., 2017. Dynamic changes in neutral and acidic ginsenosides with different cultivation ages and harvest seasons: Identification of chemical characteristics for Panax ginseng quality control. Molecules, Vol. 22. 10.3390/molecules22050734.
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  38. Hu, J.N., Z. Liu, Z. Wang, X.D. Li, L.X. Zhang, W. Li and Y.P. Wang, 2017. Ameliorative effects and possible molecular mechanism of action of black ginseng (Panax ginseng) on acetaminophen-mediated liver injury. Molecules, Vol. 22. 10.3390/molecules22040664.
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  39. Han, X.Y., J.N. Hu, Z. Wang, S.N. Wei, S.W. Zheng, Y.P. Wang and W. Li, 2017. 5-HMF attenuates liver fibrosis in CCl4-plus-alcohol-induced mice by suppression of oxidative stress. J. Nutr. Sci. Vitaminol., 63: 135-143.
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  40. Zheng, S., W. Li, J. Wang, Y. Chen and W. Hou et al., 2016. Platycodin D inhibits B16F10 melanoma metastasis via antiangiogenic activity. RSC Adv., 6: 10606-10614.
    CrossRef  |  Direct Link  |  
  41. Li, W., Y.H. Tian, Y. Liu, Z. Wang, S. Tang, J. Zhang and Y.P. Wang, 2016. Platycodin D exerts anti-tumor efficacy in H22 tumor-bearing mice via improving immune function and inducing apoptosis. J. Toxicol. Sci., 41: 417-428.
    CrossRef  |  Direct Link  |  
  42. Li, W., M.H. Yan, Y. Liu, Z. Liu and Z. Wang et al., 2016. Ginsenoside Rg5 ameliorates cisplatin-induced nephrotoxicity in mice through inhibition of inflammation, oxidative stress and apoptosis. Nutrients, Vol. 8. 10.3390/nu8090566.
    CrossRef  |  Direct Link  |  
  43. He, Y.F., M.L. Nan, Y.W. Zhao, W.Y. Sun, W. Li and Q.C. Zhao, 2016. Design, synthesis and evaluation of antitumor activity of new rotundic acid acylhydrazone derivatives. Zeitschrift fur Naturforschung C, 71: 95-103.
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  44. Cai, E.B., L.M. Yang, C.X. Jia, W.Y. Zhang and Y. Zhao et al., 2016. The synthesis and evaluation of arctigenin amino acid ester derivatives. Chem. Pharm. Bull., 64: 1466-1473.
    CrossRef  |  Direct Link  |  
  45. Wei, S., W. Li, Y. Yu, F. Yao and A. Lixiang et al., 2015. Ginsenoside compound K suppresses the hepatic gluconeogenesis via activating adenosine-5’monophosphate kinase: A study in vitro and in vivo. Life Sci., 139: 8-15.
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  46. Sun, Y., W. Li and Z. Liu, 2015. Preparative isolation, quantification and antioxidant activity of dihydrochalcones from Sweet Tea (Lithocarpus polystachyus Rehd.). J. Chromatogr. B, 1002: 372-378.
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  47. Li, W., Z. Wang, J. Gu, L. Chen, W. Hou, Y. Jin and Y. Wang, 2015. Bioconversion of ginsenoside rd to ginsenoside m1 by snailase hydrolysis and its enhancement effect on insulin secretion in vitro. Die Pharmazie-Int. J. Pharm. Sci., 70: 340-346.
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  48. Li, W., Y. Liu, Z. Wang, Y. Han and Y.H. Tian et al., 2015. Platycodin D isolated from the aerial parts of Platycodon grandiflorum protects alcohol-induced liver injury in mice. Food Funct., 6: 1418-1427.
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  49. Li, W., X.N. Qu, Y. Han, S.W. Zheng, J. Wang and Y.P. Wang, 2015. Ameliorative effect of 5-hydroxymethyl-2-furfural (5-HMF) on acute alcoholic liver oxidative injury in mice. Int. J. Mol. Sci., 16: 2446-2457.
  50. Li, W., X.M. Su, Y. Han, Q. Xu, J. Zhang, Z. Wang and Y.P. Wang, 2015. Maltol, a Maillard reaction product, exerts anti-tumor efficacy in H22 tumor-bearing mice via improving immune function and inducing apoptosis. RSC Adv., 5: 101850-101859.
    CrossRef  |  Direct Link  |  
  51. Li, W., Q. Xu, Y.F. He, Y. Liu and S.B. Yang et al., 2015. Anti-tumor effect of steamed Codonopsis lanceolata in H22 tumor-bearing mice and its possible mechanism. Nutrients, 7: 8294-8307.
    CrossRef  |  Direct Link  |  
  52. Jin, Y.P., W. Li, S. Yan and Y.P. Wang, 2015. Characterization of three oleane-type saponins from Panax ginseng. Chem. Nat. Compounds, 51: 1193-1195.
    CrossRef  |  Direct Link  |  
  53. Han, Y., Q. Xu, J.N. Hu, X.Y. Han, W. Li and L.C. Zhao, 2015. Maltol, a food flavoring agent, attenuates acute alcohol-induced oxidative damage in mice. Nutrients, 7: 682-696.
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  54. Zhang, B., H. Ye, X.M. Zhu, J.N. Hu and H.Y. Li et al., 2014. Esterification enhanced intestinal absorption of ginsenoside Rh2 in Caco-2 cells without impacts on its protective effects against H2O2-induced cell injury in human umbilical vein endothelial cells (HUVECs). J. Agric. Food Chem., 62: 2096-2103.
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  55. San, Z., Y. Fu, W. Li, E. Zhou and Y. Li et al., 2014. Protective effect of taraxasterol on acute lung injury induced by lipopolysaccharide in mice. Int. Immunopharmacol., 19: 342-350.
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  56. Guan, F.Y., J. Gu, W. Li, M. Zhang and Y. Ji et al., 2014. Compound K protects pancreatic islet cells against apoptosis through inhibition of the AMPK/JNK pathway in type 2 diabetic mice and in MIN6 β-cells. Life Sci., 107: 42-49.
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  57. Wang, Z., L.C. Zhao, W. Li, L.X. Zhang, J. Zhang and J. Liang, 2013. Highly efficient biotransformation of polydatin to resveratrol by snailase hydrolysis using response surface methodology optimization. Molecules, 18: 9717-9726.
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  58. Liu, Z., W. Li, X. Li, M. Zhang and L. Chen et al., 2013. Antidiabetic effects of malonyl ginsenosides from Panax ginseng on type 2 diabetic rats induced by high-fat diet and streptozotocin. J. Ethnopharmacol., 145: 233-240.
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  59. Li, W., L.L. Shi, L.Q. Han and J. Zhang, 2013. Development and validation of a RP-HPLC method for simultaneous determination of salicin and eight flavonoids in leaves of Salix matsudana Koidz. Acta Chromatogr., 25: 735-743.
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  60. He, Y.F., M.L. Nan, J.M. Sun, Z.J. Meng, W. Li and M. Zhang, 2013. Design, synthesis and cytotoxicity of cell death mechanism of rotundic acid derivatives. Bioorg. Med. Chem. Lett., 23: 2543-2547.
    CrossRef  |  Direct Link  |  
  61. Gu, J., W. Li, D. Xiao, S. Wei and W. Cui et al., 2013. Compound K, a final intestinal metabolite of ginsenosides, enhances insulin secretion in MIN6 pancreatic β-cells by upregulation of GLUT2. Fitoterapia, 87: 84-88.
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  62. Li, W., Z. Wang, Y.P. Wang, C. Jiang, Q. Liu, Y.S. Sun and Y.N. Zheng, 2012. Pressurised liquid extraction combining LC–DAD–ESI/MS analysis as an alternative method to extract three major flavones in Citrus reticulate ‘chachi’(Guangchenpi). Food Chem., 130: 1044-1049.
    CrossRef  |  Direct Link  |  
  63. Li, W., Y.S. Sun, Z. Wang and Y.N. Zheng, 2012. Isolation and purification of saponins from Platycodon grandiflorum by semi-preparative high performance liquid chromatography and lc/esi-ms. J. Liq. Chrom. Relat. Technol., 35: 547-557.
    CrossRef  |  Direct Link  |  
  64. Li, W., M. Zhang, J. Gu, Z.J. Meng and L.C. Zhao et al., 2012. Hypoglycemic effect of protopanaxadiol-type ginsenosides and compound K on Type 2 diabetes mice induced by high-fat diet combining with streptozotocin via suppression of hepatic gluconeogenesis. Fitoterapia, 83: 192-198.
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  65. Li, W., L.C. Zhao, Z. Wang, Y.N. Zheng, J. Liang and H. Wang, 2012. Response surface methodology to optimize enzymatic preparation of deapio-platycodin d and platycodin d from radix platycodi. Int. J. Mol. Sci., 13: 4089-4100.
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  66. Li, W., L.C. Zhao, Y.S. Sun, F.J. Lei, Z. Wang, X.B. Gui and H. Wang, 2012. Optimization of pressurized liquid extraction of three major acetophenones from Cynanchum bungei using a box-behnken design. Int. J. Mol. Sci., 13: 14533-14544.
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  67. Li, W., M. Zhang, Z. Wang, Y.P. Wang, Y.N. Zheng and J. Zhang, 2011. Simultaneous RP-HPLC determination of six platycosides: Application to an enzymatic preparation study. Chromatographia, 74: 777-782.
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  68. Li, W., M. Zhang, Y.N. Zheng, J. Li and Y.P. Wang et al, 2011. Snailase preparation of ginsenoside M1 from protopanaxadiol-type ginsenoside and their protective effects against CCl4-induced chronic hepatotoxicity in mice. Molecules, 16: 10093-10103.
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  69. Li, W., Z. Wang, L. Chen, J. Zhang, L. Han, J. Hou and Y. Zheng, 2010. Pressurized liquid extraction followed by LC‐ESI/MS for analysis of four chromones in radix saposhnikoviae. J. Sep. Sci., 33: 2881-2887.
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  70. Li, W., Z. Liu, Z. Wang, L. Chen, Y. Sun, J. Hou and Y. Zheng, 2010. Application of accelerated solvent extraction to the investigation of saikosaponins from the roots of Bupleurum falcatum. J. Sep. Sci., 33: 1870-1876.
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  71. Li, W., W. Zhang, L. Xiang, Z. Wang and Y.N. Zheng et al., 2010. Platycoside N: A new oleanane-type triterpenoid saponin from the roots of Platycodon grandiflorum. Molecules, 15: 8702-8708.
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  72. Li, W., L. Xiang, J. Zhang, Y.N. Zheng, L.K. Han and M. Saito, 2007. A new triterpenoid saponin from the roots of Platycodon grandiflorum. Chin. Chem. Lett., 18: 306-308.
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