Dr. Fu Ming Tsai
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Dr. Fu Ming Tsai

Research Associate
The Buddhist Tzuchi Medical Foundation, Taiwan


Highest Degree
Ph.D. in Medical Microbiology and Immunology from National Denfense Medical Center, Taiwan

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Area of Interest:

Biomedical Sciences
100%
Molecular Biology
62%
Cell Biology
90%
Tumor Biology
75%
Microbiology
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
44
Abstracts
0

Selected Publications

  1. Wang, T.S., Y.C. Chen, F.M. Tsai, Y.Y. Chang, Y.H. Chen, C.Y. Kuo and M.L. Chen, 2020. MicroRNA expression profiles in C6 glioblastoma cell line treated with antipsychotics. Indian J. Pharm. Sci., 82: 409-419.
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  2. Wang, C.H., L.K. Wang, C.C. Wu, M.L. Chen, C.Y. Kuo, R.Y. Shyu and F.M. Tsai, 2020. Cathepsin V mediates the tazarotene-induced gene 1-induced reduction in invasion in colorectal cancer cells. Cell Biochem. Biophys., 78: 483-494.
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  3. Wang, C.C., L.K. Wang, M.L. Chen, C.Y. Kuo, F.M. Tsai and C.H. Wang, 2020. Triterpenes in the ethanol extract of Poria cocos induce dermal papilla cell proliferation. Int. J. Pharmacol., 16: 1-9.
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  4. Kuo, C.Y., V. Chiu, P.C. Hsieh, C.Y. Huang and S.J. Huang, et al., 2020. Chrysophanol attenuates hepatitis B virus X protein-induced hepatic stellate cell fibrosis by regulating endoplasmic reticulum stress and ferroptosis. J. Pharmacol. Sci., 144: 172-182.
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  5. Chen, Y.C., F.M. Tsai and M.L. Chen, 2020. Antipsychotic drugs reverse MK801-inhibited cell migration and F-actin condensation by modulating the rho signaling pathway in B35 cells. Behav. Neurol., 10.1155/2020/4163274.
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  6. Yeh, Y.H., C.Y. Liang, M.L. Chen, F.M. Tsai and Y.Y. Lin et al., 2019. Apoptotic effects of hsian‐tsao (Mesona procumbens Hemsley) on hepatic stellate cells mediated by reactive oxygen species and ERK, JNK and caspase‐3 pathways. Food Sci. Nutr., 7: 1891-1898.
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  7. Wang, C.H., L.K. Wang, C.C. Wu, M.L. Chen, M.C. Lee, Y.Y. Lin and F.M. Tsai, 2019. The ribosomal protein RPLP0 mediates PLAAT4-induced cell cycle arrest and cell apoptosis. Cell Biochem. Biophys., 77: 253-260.
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  8. Tsai, F.M., L.K. Wang, M.L. Chen, M.C. Lee, Y.Y. Lin and C.H. Wang, 2019. Induction of cell proliferation and cell death in human follicle dermal papilla cells by zinc chloride. Indian J. Pharm. Sci., 81: 781-785.
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  9. Tsai, F.M., C.H. Li, L.K. Wang, M.L. Chen, M.C. Lee, Y.Y. Lin and C.H. Wang, 2019. Extracellular signal-regulated kinase mediates ebastine-induced human follicle dermal papilla cell proliferation. BioMed Res. Int., Vol. 2019. 10.1155/2019/6360503.
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  10. Shyu, R.Y., C.H. Wang, C.C. Wu, L.K. Wang and M.L. Chen, et al., 2019. Tazarotene-induced gene 1 (TIG1) interacts with serine protease inhibitor kazal-type 2 (SPINK2) to inhibit cellular invasion of testicular carcinoma cells. BioMed. Res. Int., 10.1155/2019/6171065.
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  11. Huang, K.L., H.L. Chang, F.M. Tsai, Y.H. Lee, C.H. Wang and T.J. Cheng, 2019. The effect of the inhalation of and topical exposure to zinc oxide nanoparticles on airway inflammation in mice. Toxicol. Appl. Pharmacol., 10.1016/j.taap.2019.114787.
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  12. Wang, L.K., F.M. Tsai, M.L. Chen, S. Wu and M.C. Lee et al., 2018. Aqueous extract of Tournefortia sarmentosa stem inhibits ADP-induced platelet aggregation. Indian J. Pharm. Sci., 80: 126-134.
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  13. Wang, C.H., R.Y. Shyu, C.C. Wu, M.L. Chen and M.C. Lee et al., 2018. Tazarotene-induced gene 1 interacts with DNAJC8 and regulates glycolysis in cervical cancer cells. Mol. Cells, 41: 562-574.
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  14. Li, T., M. Lee, F. Tsai, Y. Chen, Y. Lin and M. Chen, 2018. Proteomic study revealed antipsychotics-induced nuclear protein regulations in B35 cells are similar to the regulations in C6 cells and rat cortex. BMC Pharmacol. Toxicol., Vol. 19. 10.1186/s40360-018-0199-0.
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  15. Wu, C.C., F.M. Tsai, M.L. Chen, S. Wu and M.C. Lee et al., 2016. Antipsychotic drugs inhibit platelet Aggregation via P2Y1 and P2Y12 receptors. BioMed Res. Int., Vol. 2016. 10.1155/2016/2532371.
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  16. Shyu, R.Y., C.H. Wang, C.C. Wu, M.L. Chen and M.C. Lee et al., 2016. Tazarotene-induced gene 1 enhanced cervical cell autophagy through transmembrane protein 192. Mol. Cells, 39: 877-887.
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  17. Chen, M.L., F.M. Tsai, M.C. Lee and Y.Y. Lin, 2016. Antipsychotic drugs induce cell cytoskeleton reorganization in glial and neuronal cells via Rho/Cdc42 signal pathway. Progr. Neuro-Psychopharmacol. Biol. Psychiatry, 71: 14-26.
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  18. Tsai, F.M., M.L. Chen, L.K. Wang and M.C. Lee, 2015. H-rev107 regulates cytochrome P450 reductase activity and increases lipid accumulation. PLoS ONE, Vol. 10. 10.1371/journal.pone.0138586.
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  19. Wang, C.H., R.Y. Shyu, C.C. Wu, T.C. Tsai and L.K. Wang et al., 2014. Phospholipase A/Acyltransferase enzyme activity of H-rev107 inhibits the H-RAS signaling pathway. J. Biomed. Sci., Vol. 21. 10.1186/1423-0127-21-36.
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  20. Chen, M.L., S. Wu, T.C. Tsai, L.K. Wang, W.M. Chou and F.M. Tsai, 2014. The caffeic acid in aqueous extract of Tournefortia sarmentosa enhances neutrophil phagocytosis of Escherichia coli. Immunopharmacol. Immunotoxicol., 36: 390-396.
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  21. Chen, M.L., S. Wu, T.C. Tsai, L.K. Wang and F.M. Tsai, 2014. Regulation of neutrophil phagocytosis of Escherichia coli by antipsychotic drugs. Int. Immunopharmacol., 23: 550-557.
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  22. Shyu, R.Y., C.C. Wu, C.H. Wang, T.C. Tsai and L.K. Wang et al., 2013. H-rev107 regulates prostaglandin D2 synthase-mediated suppression of cellular invasion in testicular cancer cells. J. Biomed. Sci., Vol. 20. 10.1186/1423-0127-20-30.
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  23. Chen, M.L., S. Wu, T.C. Tsai, L.K. Wang, W.M. Chou and F.M. Tsai, 2013. Effect of aqueous extract of Tournefortia sarmentosa on the regulation of macrophage immune response. Int. Immunopharmacol., 17: 1002-1008.
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  24. Chen, M.L., S. Wu, T.C. Tsai, L.K. Wang and F.M. Tsai, 2013. Regulation of macrophage immune responses by antipsychotic drugs. Immunopharmacol. Immunotoxicol., 35: 573-580.
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  25. Wu, C.C., R.Y. Shyu, C.H. Wang, T.C. Tsai and L.K. Wang et al., 2012. Involvement of the prostaglandin D2 signal pathway in retinoid-inducible gene 1 (RIG1)-mediated suppression of cell invasion in testis cancer cells. Biochim. Biophys. Acta (BBA)-Mol. Cell Res., 1823: 2227-2236.
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  26. Chen, M.L., T.C. Tsai, L.K. Wang, Y.Y. Lin, Y.M. Tsai, M.C. Lee and F.M. Tsai, 2012. Risperidone modulates the cytokine and chemokine release of dendritic cells and induces TNF-α-directed cell apoptosis in neutrophils. Int. Immunopharmacol., 12: 197-204.
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  27. Chen, M.L., T.C. Tsai, L.K. Wang, Y.Y. Lin, Y.M. Tsai, M.C. Lee and F.M. Tsai, 2012. Clozapine inhibits Th1 cell differentiation and causes the suppression of IFN-γ production in peripheral blood mononuclear cells. Immunopharmacol. Immunotoxicol., 34: 686-694.
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  28. Wu, C.C., F.M. Tsai, R.Y. Shyu, Y.M. Tsai, C.H. Wang and S.Y. Jiang, 2011. G protein-coupled receptor kinase 5 mediates Tazarotene-induced gene 1-induced growth suppression of human colon cancer cells. BMC Cancer, Vol. 11. 10.1186/1471-2407-11-175.
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  29. Tsai, F.M., C.C. Wu, R.Y. Shyu, C.H. Wang and S.Y. Jiang, 2011. Tazarotene-induced gene 1 inhibits prostaglandin E2-stimulated HCT116 colon cancer cell growth. J. Biomed. Sci., Vol. 18. 10.1186/1423-0127-18-88.
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  30. Chen, M.L., T.C. Tsai, Y.Y. Lin, Y.M. Tsai, L.K. Wang, M.C. Lee and F.M. Tsai, 2011. Antipsychotic drugs suppress the AKT/NF-kappaB pathway and regulate the differentiation of T-cell subsets. Immunol. Lett., 140: 81-91.
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  31. Tsai, F.M., R.Y. Shyu, S.C. Lin, C.C. Wu and S.Y. Jiang, 2009. Induction of apoptosis by the retinoid inducible growth regulator RIG1 depends on the NC motif in HtTA cervical cancer cells. BMC Cell Biol., Vol. 10. 10.1186/1471-2121-10-15.
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  32. Shyu, R.Y., Y.C. Hsieh, F.M. Tsai, C.C. Wu and S.Y. Jiang, 2008. Cloning and functional characterization of the HRASLS2 gene. Amino Acids, 35: 129-137.
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  33. Tsai, F.M., R.Y. Shyu and S.Y. Jiang, 2007. RIG1 suppresses Ras activation and induces cellular apoptosis at the Golgi apparatus. Cell. Signall., 19: 989-999.
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  34. Tsai, F.M., R.Y. Shyu and S.Y. Jiang, 2006. RIG1 inhibits the Ras/mitogen-activated protein kinase pathway by suppressing the activation of Ras. Cell. Signall., 18: 349-358.
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