Dr. Sima Said Zein
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Dr. Sima Said Zein

Associate Professor
Department of Pharmaceutical Biotechnology, Al-Ahliyya Amman University, Amman, Jordan

Highest Degree
Ph.D. in Molecular and Cell Biology from The University of Texas at Dallas, Texas

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Area of Interest:

Biomedical Sciences
100%
Molecular and Cellular Biology
62%
Immunology
90%
Nanobiotechnology
75%
Genetics and Genomics
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
19
Abstracts
0

Selected Publications

  1. Al-Awaida W., B.J. Al-Hourani, M. Akash, W.H. Talib, S. Zein, R.R. Falah and Z. Aburubaiha, 2018. In vitro anticancer, anti-inflammatory, and antioxidant potentials of Ephedra aphylla. J. Can. Res. Ther., 14: 1350-1354.
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  2. Korth, C., B. Meeus, J. Theuns, C. Van Broeckhoven and F. Zufall et al., 2012. Identification of dominant human aquaporin 4 T-cell epitopes: Observations in neuromyelitis optica with implications for other autoimmune disorders. Arch. Neurol., 69: 1093-1120.
  3. Arellano, B., R. Hussain, T. Zacharias, J. Yoon and C. David et al., 2012. Human aquaporin 4281-300 is the immunodominant linear determinant in the context of HLA-DRB1* 03: 01: Relevance for diagnosing and monitoring patients with neuromyelitis optica. Arch. Neurol., 69: 1125-1131.
    CrossRef  |  Direct Link  |  
  4. Denton, P.W., F. Othieno, F. Martinez-Torres, W. Zou and J.F. Krisko et al., 2011. Topically applied 1% tenofovir in humanized BLT mice using the CAPRISA 004 experimental design demonstrates partial protection from vaginal HIV infection validating the BLT model for the evaluation of new microbicide candidates. J. Virol., 10.1128/JVI.00537-11.
    CrossRef  |  Direct Link  |  
  5. Zein, S.S., W. Hu, S. Nessler, B.Hemmer and T. Eagar et al., 2010. Pharmacological PrP-silencing accelerates CNS autoimmune disease via TCR signaling. Neurology, 9: A496-A496.
    Direct Link  |  
  6. Zein, S., W. Li, V. Ramakrishnan, T.F. Lou, S. Sivanand, A. Mackie and B. Pace, 2010. Identification of fetal hemoglobin-inducing agents using the human leukemia KU812 cell line. Exp. Biol. Med., 235: 1385-1394.
    CrossRef  |  Direct Link  |  
  7. Kodeboyina, S., S. Zein, M. Lee, P. Balamurugan, X. Yao and B. Pace, 2008. Role of Cjun in Gγ-globin gene trans-Activation. Blood, 11: 1870-1875.
  8. Pace, B.S., M.S. Lee, X. Yao, S. Zein and J. Sangerman, 2007. Histone deacetylase inhibitors induce γ-globin expression by p38 MAPK-mediated CREB and ATF-2 activation. Blood Cells Mol. Dis., Vol. 38. 10.1016/j.bcmd.2006.10.106.
    CrossRef  |  Direct Link  |  
  9. Sangerman, J., M.S. Lee, X. Yao, E. Oteng and C.H. Hsiao et al., 2006. Mechanism for fetal hemoglobin induction by histone deacetylase inhibitors involves γ-globin activation by CREB1 and ATF-2. Blood, 108: 3590-3599.
    CrossRef  |  Direct Link  |  
  10. Pace, B.S. and S. Zein, 2006. Understanding mechanisms of γ‐globin gene regulation to develop strategies for pharmacological fetal hemoglobin induction. Dev. Dyn., 235: 1727-1737.
    CrossRef  |  Direct Link  |  
  11. Zein, S.S. and S.D. Levene, 2005. Structural aspects of RecA-dependent homologous strand exchange involving human telomeric DNA. Biochemistry, 44: 4817-4828.
    CrossRef  |  Direct Link  |  
  12. Zein, S., A. Vetcher and S.D. Levene, 2005. Synthesis of repetitive single-stranded DNA by PCR for applications to nanobiotechnology. Int. J. Nanosci., 4: 287-294.
  13. Vash, B., N. Phung, S. Zein and D. DeCamp, 1998. Three complement-type repeats of the low-density lipoprotein receptor-related protein define a common binding site for RAP, PAI-1 and lactoferrin. Blood, 92: 3277-3285.