1. Sharma, V.D., J. Lees, N.E. Hoffman, E. Brailoiu, M. Madesh, S.L. Wunder and M.A. Ilies, 2014. Modulation of pyridinium cationic lipid-DNA complex properties by pyridinium gemini surfactants and its impact on lipoplex transfection properties. Mol. Pharmaceutics, 11: 545-559.
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2. Miller, B.A., N.E. Hoffman, S. Merali, X.Q. Zhang and J.F. Wang et al., 2014. TRPM2 Channels Protect Against Cardiac Ischemia-Reperfusion Injury: Role of Mitochondria. J. Biol. Chem., 289: 7615-7629.
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3. Hoffman, N.E., H.C. Chandramoorthy, S. Santhanam, X. Zhang and S. Vallem et al., 2014. SLC25A23 augments mitochondrial Ca2+ uptake, interacts with MCU, and induces oxidative stress-mediated cell death. Mol. Biol. Cell, 25: 934-947.
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4. Bansaghi, S., T. Golenar, M. Madesh, G. Csordas and S. RamachandraRao, et al., 2014. Isoform-and species-specific control of IP3 receptors by reactive oxygen species. J. Biol. Chem., 289: 8170-8181.
5. Pan, J.A., Y. Fan, R. Kumar, M. Madesh and W.X. Zong, 2013. Hyperactivation of the mammalian degenerin MDEG leads to intracellular activation of caspase-8 and apoptosis. J. Biol. Chem., 288: 2952-2963.
6. Mancarella, S., S. Potireddy, Y. Wang, H. Gao and R. Gandhirajan et al., 2013. Targeted STIM deletion impairs calcium homeostasis, NFAT activation, and growth of smooth muscle. FASEB J., 27: 893-906.
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7. Justine, Y., E. Deliu, H.Q. Zhang, N.E. Hoffman and R.L. Carter et al., 2013. Differential Activation of Cultured Neonatal Cardiomyocytes by Plasmalemmal vs Intracellular GPR55. J. Biol. Chem., 288: 22481-22492.
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8. Hoffman, N.E., H.C. Chandramoorthy, S. Santhanam, X. Zhang and S. Rajan et al., 2013. MICU1 Motifs Define Mitochondrial Calcium Uniporter Binding and Activity. Cell Rep., 26: 1576-1588.
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9. Gandhirajan, R.M., S. Meng, H.C. Chandramoorthy, K. Mallilankaraman and S. Mancarella et al., 2013. Blockade of NOX2 and STIM1 signaling limits lipopolysaccharide-induced vascular inflammation. J. Clin. Invest., 123: 887-902.
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10. Duran, J.M., C.A. Makarewich, T.E. Sharp, T. Starosta and F. Zhu et al., 2013. Bone-derived stem cells repair the heart after myocardial infarction through transdifferentiation and paracrine signaling mechanisms. Circulation Res., 113: 539-552.
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11. Deliu, E.G., C. Brailoiu, N.E. Hoffman, M. Madesh, W.J. Koch and E. Brailoiu, 2013. Direct evidence of intracrine angiotensin II signaling in neurons. Am. J. Physiol., 306: 736-744.
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12. Barrero, C.A., O. Perez-Leal, M. Aksoy, C. Moncada and Y. Lopez et al., 2013. Histone 3.3 participates in a self- sustaining cascade of apoptosis that contributes to the progression of chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med., 188: 673-683.
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13. Yin, Y., J.L. Pastrana, X. Li, X. Huang and K. Mallilankaraman et al., 2012. Inflammasomes: Sensors of Metabolic Stresses for Vascular Inflammation. Front. Biosci., 18: 638-649.
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14. Soboloff, J., B. Rothberg, M. Madesh and D.G. Gill, 2012. STIM proteins: dynamic calcium signal transducers. Nat. Rev. Mol. Cell Biol., 13: 549-565.
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15. Mallilankaraman, K., P.J. Doonan, C. Cardenas, H.C. Chandramoorthy and M. Muller et al., 2012. MICU1 is an Essential Gatekeeper for MCU-Mediated Mitochondrial Ca2+ Uptake That Regulates Cell Survival. Cell, 151: 630-644.
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16. Mallilankaraman, K., C. Cardenas, P.J. Doonan, K.M. Irrinki and H.C. Chandramoorthy et al., 2012. MCUR1 is an Essential Component of Mitochondrial Ca2+ Uptake that Regulates Cellular Metabolism. Nat. Cell Biol., 14: 1336-1343.
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17. Kato, K., E.P. Lillehoj, Y.S. Park, T. Umehara, N.E. Hoffman, M. Madesh and K.C. Kim, 2012. Membrane-tethered MUC1 Mucin is Phosphorylated by EGFR in Airway Epithelial Cells and Associates with TLR5 to Inhibit Recruitment of MyD88. J. Immunol., 188: 2014-2022.
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18. Deliu, E.G., C. Brailoiu, A.S. Undieh, M. Madesh, W.J. Koch and E. Brailoiu, 2012. Intracellular ETB receptor-driven Ca2+ signal elicits NO production in endothelial cells. J. Biol. Chem., 287: 41023-41031.
19. Thapa, R.J., S.H. Basagoudanavar, K.M. Irrinki, K. Mallilankaraman, A.A. Beg, M. Madesh and S. Balachandran, 2011. NF-κB protects cells from IFN-γ-induced RIP1-dependent necroptosis. Mol. Cell. Biol., 31: 2934-2946.
20. Soboloff, J., M. Madesh and D.G. Gill, 2011. Sensing Cellular Stress through STIM Proteins. Nat. Chem. Biol., 7: 488-492.
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21. Shuvaev, V.V., J. Han, K. Yu, S. Huang and B.J. Hawkins et al., 2011. PECAM-Targeted Delivery of SOD Inhibits Endothelial Inflammatory Response to Cytokines. FASEB J., 25: 348-357.
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22. Mancarella, S., Y. Wang, X. Deng, J.R. Panettieri, M. Madesh and D.G. Gill, 2011. Hypoxia-induced acidosis uncouples the STIM-Orai calcium signaling complex. J. Biol. Chem., 286: 44788-44798.
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23. Irrinki, K.M., K. Mallilankaraman, R.J. Thapa, F.J. Smith and N.R. Jog et al., 2011. Requirement of FADD, NEMO and BAX/BAK for aberrant mitochondrial function in TNF-induced necrosis. Mol. Cell. Biol., 31: 3745-3758.
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24. Cheng, Z.J., X. Jiang, W. Kruger, D. Pratico and S. Gupta et al., 2011. Hyper-homocysteinemia impairs endothelium-derived hyperpolarizing factor-mediated vasorelaxation in transgenic cystathionine beta-synthase deficient mice. Blood, 118: 1998-2006.
25. Hawkins, B.J., M.D. Levin, P.J. Doonan, N.B. Petrenko, C.W. Davis, V.V. Patel and M. Madesh, 2010. Mitochondrial complex II prevents hypoxic but not calcium- and proapoptotic Bcl-2 protein-induced mitochondrial membrane potential loss. J. Biol. Chem., 285: 26494-26505.
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26. Hawkins, B.J., K.M. Irrinki, K. Mallilankaraman, Y.C. Lien and Y. Wang et al., 2010. S-glutathionylation activates STIM1 and alters mitochondrial homeostasis. J. Cell Biol., 190: 391-405.
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27. Davis, C.W., B.J. Hawkins, S. Ramasamy, K.M. Irrinki and B.A. Cameron et al., 2010. Nitration of the Mitochondrial Complex I Subunit NDUFB8 Elicits RIP1 and 3-Mediated Necrosis. Free Radical Biol. Med., 48: 306-317.
28. Brailoiu, G.C., B. Gurzu1, X. Gao, R. Parkesh and P.K. Aley et al., 2010. Acidic NAADP-sensitive calcium stores in the endothelium: agonist-specific recruitment and role in regulating blood pressure. J. Biol. Chem., 285: 37133-37137.
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29. Roy, S.S., M. Madesh, E. Davies, B. Antonsson, N. Danial and G. Hajnoczky, 2009. Bad targets the permeability transition pore independent of Bax or Bak to switch between Ca2+-dependent cell survival and death. Mol. Cell, 33: 377-388.
30. Madesh, M., W.X. Zong, B.J. Hawkins, R. Subbiah and T. Venkatachalam et al., 2009. Execution of superoxide-induced cell death by the proapoptotic Bcl-2-related proteins Bid and Bak. Mol. Cell. Biol., 29: 3099-3112.
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31. Levin, M.D., M.M. Lu, N.B. Petrenko, B.J. Hawkins and D. Lang et al., 2009. Melanocyte-like cells in the heart and pulmonary veins contribute to atrial arrhythmia triggers. J. Clin. Invest., 119: 3420-3436.
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32. Yang, H., G. Liang, B.J. Hawkins, M. Madesh, A. Pierwola and H. Wei, 2008. Inhalational Anesthetics Induce Cell Damage by Disruption of Intracellular Calcium Homeostasis with Different Potencies. Anesthesiol., 109: 243-250.
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33. Wei, H., G. Liang, H. Yang, Q. Wang and B.J. Hawkins et al., 2008. The common inhalational anesthetic isoflurane induces apoptosis via activation of inositol 1,4,5-trisphosphate receptors. Anesthesiol., 108: 251-260.
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34. Milovanova, T., S. Chatterjee, B.J. Hawkins, N. Hong and N. Sorokina et al., 2008. Caveolae are an essential component of the pathway for endothelial cell signaling associated with abrupt reduction of shear stress. Biochim Biophys Acta, 1783: 1866-1875.
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35. Dziubla, T.D., V.V. Shuvaev, N.K. Hong, B.J. Hawkins and M. Madesh et al., 2008. Endothelial targeting of semi-permeable stealth polymer nanocarriers for delivery of durable enzyme therapies. Biomater., 29: 215-227.
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36. Mukhopadhyay, P., M. Rajesh, G. Hasko, B.J. Hawkins, M. Madesh and P. Pacher, 2007. Simultaneous detection of apoptosis and mitochondrial superoxide production in live cells by flow cytometry and confocal microscopy. Nat. Protoc., 2: 2295-2301.
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37. Jones, R.G., T. Bui, C. White, M. Madesh and C.M. Krawczyk et al., 2007. Bax and Bak regulate T cell proliferation through control of ER Ca2+ homeostasis. Immun., 27: 268-280.
38. Hawkins, B.J., M. Madesh, C.J. Kirkpatrick and A.B. Fisher, 2007. Superoxide flux in endothelial cells via the chloride channel-3 mediates intracellular signaling. Mol. Biol. Cell 18: 2002-2012.
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39. Cheong, N., H. Zhang, M. Madesh, M. Zhao and K. Yu et al., 2007. ABCA3 is critical for lamellar body biogenesis in vivo. J. Biol. Chem., 282: 23811-23817.
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40. Muthumani, K., A.Y. Choo, W.X. Zong, M. Madesh and D.S. Hwang et al., 2006. The HIV-1 Vpr and glucocorticoid receptor complex: A gain-of-function interaction that prevents the nuclear localization of PARP-1. Nat. Cell Biol., 8: 170-179.
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41. Milovanova, T., S. Chatterjee, Y. Manevich, I. Kotelnikova and K. Debolt et al., 2006. Lung Endothelial Cell Proliferation with Decreased Shear Stress is Mediated by Reactive Oxygen Species. Am. J.Physiol., 290: 66-76.
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42. Cheong, N., M. Madesh, L.W. Gonzales, M. Zhao, K. Yu, P.L. Ballard and H. Shuman, 2006. Functional and Trafficking Defects of ABCA3 Transporter Mutants in Respiratory Distress Syndrome. J. Biol. Chem., 281: 9791-9800.
43. White, C., C. Li, J. Yang, N.B. Petrenko, M. Madesh, C.B. Thompson and J.K. Foskett, 2005. The endoplasmic reticulum gateway to apoptosis: Bcl-XL modulation of the InsP3 receptor. Nat. Cell Biol., 7: 1021-1028.
44. Mulugeta, S., V. Nguyen, S.J. Russo, M. Madesh and M.F. Beers, 2005. A ProSP-C BRICHOS Domain Mutation causes ER Stress, Proteosome Dysfunction, and Caspase 3 Activation. Am. J. Respir. Cell Mol. Biol., 32: 521-530.
45. Madesh, M., B.J. Hawkins, T. Milovanova, C.D. Bhanumathy and S.K. Joseph et al., 2005. Selective role for superoxide in InsP3R-mediated mitochondrial dysfunction and endothelial apoptosis. J. Cell Biol., 170: 1079-1090.
46. Kazerounian, S., G.M. Pitari, F.J. Shah, G.S. Frick and M. Madesh et al., 2005. Proliferative Signaling by Store- Operated Calcium Channels Opposes Colon Cancer Cell Cytostasis Induced By Bacterial Enterotoxins. J. Pharmacol. Exp. Ther., 314: 1013-1022.
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47. Sharma, K., L. Deelman, M. Madesh, B. Kurz and E. Ciccone et al., 2003. Involvement of Transforming Growth Factor- in Rregulation of Calcium Transients in Diabetic Vascular Smooth Muscle Cells. Am. J. Physiol., 285: 1258-1270.
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48. Hegde, R., S.M. Srinivasula, P. Datta, M. Madesh and R. Wassell et al., 2003. The polypeptide chain releasing factor GSPT1/eRF3 is proteolytically processed into an IAP- binding protein. J. Biol. Chem., 278: 38699-38706.
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49. Hajnoczky, G., E. Davies and M. Madesh, 2003. Calcium signaling and apoptosis. Biochem. Biophys. Res. Commun., 304: 445-454.
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50. McGowan, T.A., M. Madesh, Y. Zhu, L. Wang and M. Russo et al., 2002. TGF-Induced Calcium Influx Involves The Type III inositol 1,4,5-Triphosphate Receptor and Regulates Actin Cytoskeleton. Am. J. Physiol., 282: 910-920.
51. Madesh, M., B. Antonsson, S.M. Srinivasula, E.S. Alnemri and G. Hajnoczky, 2002. Rapid Kinetics of tBID-Induced Cytochrome c and Smac/DIABLO Release and Mitochondrial Depolarization. J. Biol. Chem., 277: 5651-5659.
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52. Csordas, G., M. Madesh, B. Antonsson and G. Hajnoczky, 2002. tcBID Promotes Ca2+ Signal Propagation to The Mitochondria: Control of Ca2+ Permeation Through the Outer Mitochondrial Membrane. EMBO J., 21: 2198-2206.
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53. Madesh, M. and G. Hajnoczky, 2001. VDAC-dependent permeabilization of the outer mitochondrial membrane by superoxide induces rapid and massive cytochrome c release. J. Cell Biol., 155: 1003-1016.
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54. Sharma, K., T.A McGowan, L. Wang, M. Madesh and V. Kaspar et al., 2000. Inhibition of Type I and III IP3Rs by TGF- is Associated with Impaired Calcium Release in Mesangial Cells. Am. J. Physiol., 278: 1022-1029.
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55. Ramachandran, A., M. Madesh and K.A. Balasubramanian, 2000. Apoptosis in the intestinal epithelium: Its relevance in normal and pathophysiological conditions. J. Gastroenterol. Hepatol., 15: 109-120.
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56. Madesh, M., A. Ramachandran, A. Pulimood, M. Vadranam and K.A. Balasubramanian, 2000. Attenuation of Intestinal Ischemia/Reperfusion Injury With Nitric Oxide: Studies on Mitochondrial Function and Lipid Changes. Biochimica et Biophysica Acta, 1500: 204-216.
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57. Hajnoczky, G., G. Csordas, M. Madesh and P. Pacher, 2000. The Machinery of Local Ca2+ Signaling Between Sarco-Endoplasmic Reticulum and Mitochondria. J. Physiol., 529: 69-81.
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58. Hajnoczky, G., G. Csordas, M. Madesh and P. Pacher, 2000. Control of Apoptosis by IP3 and Ryanodine Receptor Driven Calcium Signals. Cell Calcium, 28: 349-363.