Biography

Dr. Sadiqa K. Quadri is currently working as Associate Research Scientist. She has completed her Ph.D. in Chemistry from Aligarh Muslim University, Aligarh, India. She is having 20 Years of Cell and Molecular Biology Research experience in Lung Biology for the treatment of Pulmonary Edema. Her area of expertise includes Develop new hypothesis and Molecular Mechanism for tightening the Cell Barrier to protect from Acute Lung Injury (ALI) or Respiratory Distress Syndrom (ARDS), Biology of Endothelial Cells and Eipthlial cells, Direct quantification of Lung Microvascular and Endothelial barrier Permeability, Mitochondrial transfer and Mitochondria Signaling, Mitochondrial transfer occurs in vivo between Exogenously administered Bone Marrow-Derived Mesenchymal stem cells (BMSCs) and the Endothelium and Alveolar Epithelium in Mouse Lungs Undergoing Endotoxin-Induced Alveolar Injury. She introduced the first direct measurements of Permeability in the Localized Endothelial Junction by the Optical Imaging Approach and developed the Point-Permeability Measurements to Quantify Barrier Properties at Localized Regions of the Endothelial Barrier. She has published 25 research articles in journals and 4 book and 4 chapters. She also worked as Reviewer for Blue Journals.

Area of Interest:

Molecular Sciences

100%

Molecular Biology

62%

Lung Biology

90%

Cell Biology

75%

Pulmonary Edema

55%

Research Publications in Numbers

Books
0

Chapters
0

Articles
0

Abstracts
0

Selected Publications

Quadri, S.K., L. Sun, M.N. Islam, L. Shapiro and J. Bhattacharya, 2012. Cadherin selectivity filter regulates endothelial sieving properties. Nat. Commun., Vol. 3. 10.1038/ncomms2107.
CrossRef | PubMed | Direct Link |
Quadri, S.K., 2012. Cross talk between focal adhesion kinase and cadherins: Role in regulating endothelial barrier function. Microvasc. Res., 83: 3-11.
CrossRef | PubMed | Direct Link |
Islam, M.N., S.R. Das, M.T. Emin, M. Wei and L. Sun et al., 2012. Mitochondrial transfer from bone-marrow-derived stromal cells to pulmonary alveoli protects against acute lung injury. Nat. Med., 18: 759-765.
CrossRef | PubMed | Direct Link |
Rowlands, D.J., M.N. Islam, S.R. Das, A. Huertas and S.K. Quadri et al., 2011. Activation of TNFR1 ectodomain shedding by mitochondrial Ca²⁺ determines the severity of inflammation in mouse lung microvessels. J. Clin. Invest., 121: 1986-1999.
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Parthasarathi, K. and S.K. Quadri, 2009. Cadherins and Connexins in Pulmonary Endothelial Function. In: The Pulmonary Endothelium: Function in Health and Disease. Voelkel, N. and S. Rounds (Ed.). Wiley, Chichester, England., pp: 33-50.
Direct Link |
Otsu, K., S. Das, S.D. Houser, S.K. Quadri, S. Bhattacharya and J. Bhattacharya, 2009. Concentration-dependent inhibition of angiogenesis by mesenchymal stem cells. Blood, 113: 4197-4205.
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Quadri, S.K. and J. Bhattacharya, 2007. Resealing of endothelial junctions by focal adhesion kinase. Am. J. Physiol. Lung Cell. Mol. Physiol., Vol. 292. 10.1152/ajplung.00228.2006.
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Parthasarathi, K., H. Ichimura, E. Monma, J. Lindert, S. Quadri, A. Issekutz and J. Bhattacharya, 2006. Connexin 43 mediates spread of Ca²⁺-dependent proinflammatory responses in lung capillaries. J. Clin. Invest., 116: 2193-2200.
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Safdar, Z., P. Wang, H. Ichimura, A.C. Issekutz, S. Quadri and J. Bhattacharya, 2003. Hyperosmolarity enhances the lung capillary barrier. J. Clin. Invest., 112: 1541-1549.
PubMed | Direct Link |
Quadri, S.K., M. Bhattacharjee, K. Parthasarathi, T. Tanita and J. Bhattacharya, 2003. Endothelial barrier strengthening by activation of focal adhesion kinase. J. Biol. Chem., 278: 13342-13349.
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Ichimura, H., K. Parthasarathi, S. Quadri, A.C. Issekutz and J. Bhattacharya, 2003. Mechano-oxidative coupling by mitochondria induces proinflammatory responses in lung venular capillaries. J. Clin. Invest., 111: 691-699.
PubMed | Direct Link |
Parthasarathi, K., H. Ichimura, S. Quadri, A. Issekutz and J. Bhattacharya, 2002. Mitochondrial reactive oxygen species regulate spatial profile of proinflammatory responses in lung venular capillaries. J. Immunol., 169: 7078-7086.
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