Dr. Ye  Fang
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Dr. Ye Fang

Research Director/VP of Research
Corning Incorporated, USA


Highest Degree
Ph.D. in Physical Chemistry from Corning Incorporated, USA

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Biography

Dr. Ye Fang is currently working as Research Director/Research Fellow at Corning Incorporated, USA. His main area of interest focuses on Pharmacology and Toxicology and Biomedical Sciences. His area of expertise includes G Protein-Coupled Receptor, Biosensor, Receptor Biology, Cell Signaling, Cancer Biology, Chemical Biology, Cell Adhesion, Biophysics, Single cell analysis, Drug Discovery, and Receptor Pharmacology. He has published 2 books, 109 research articles in journals contributed as author/co-author.

Area of Interest:

Biomedical Sciences
100%
Biosensor
62%
Receptor Biology
90%
Cell Signaling
75%
Chemical Biology
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
0
Abstracts
0

Selected Publications

  1. Randle, D.H., Y. Fang and R.M. Eglen, 2017. 3D cell culture and dish-based organogenesis: optimizing in vitro cellular physiology. In: High Throughput Screening Methods: Evolution and Refinement. Bittker, J.A. and N.R. Ross, (Ed.)., Royal Society of Chemistry, London, England, pp: 239-251.
  2. Febles, N.K., S. Chandrasekaran and Y. Fang, 2017. Resonant waveguide grating imager for single cell monitoring of the invasion of spheroidal cancer cells through Matrigel. Methods Mol. Biol., .
  3. Fang, Y., 2017. Label-free screening technologies. Compr. Med. Chem. III, .
  4. Fang, Y. and R.M. Eglen, 2017. 3D cell cultures in drug discovery and development. J. Biomol. Screen, .
  5. Wang, J., X. Zhang, Y. Fang and X. Liang, 2016. Label-free cell phenotypic assays for assessing drug polypharmacology. Curr. Pharm. Des., 22: 3190-3200.
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  6. Pambianchi, M.S., M. Dejneka, T. Gross, A. Ellison and S. Gomez, et al., 2016. Corning Incorporated: Designing a New Future with Glass and Optics. In: Materials Research for Manufacturing. Madsen, L.D. and E.B. Svedberg, (Ed.). Springer International Publishing, New York, pp: 1-38.
  7. Nazirizadeh, Y., V. Behrends, A. Prosz, N. Orgovan and R. Horvath, et al., 2016. Intensity interrogation near cutoff resonance for label-free cellular profiling. Sci. Rep., .
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  8. Hu, H., H. Deng and Y. Fang, 2016. Label-free cell phenotypic identification of d-luciferin as an agonist for GPR35. Biolumin. Methods Protoc., 1461: 3-17.
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  9. French, J.B., S.A. Jones, H. Deng, A.M. Pedley and D. Kim, et al., 2016. Spatial colocalization and functional link of purinosomes with mitochondria. Sci., 351: 733-737.
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  10. Fang, Y., 2016. Editorial: Label-free technologies and pharmacology. Pharmacol. Res., 108: 88-89.
  11. Fang, Y., 2016. Compound annotation with real time cellular activity profiles to improve drug discovery. Expert Opini. Drug Discovery, 11: 269-280.
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  12. Liang, X., J. Wang, X. Zhang and Y. Fang, 2015. Label-free cell phenotypic identification of active compounds in traditional chinese medicines. Methods Pharmacol. Toxicol., 53: 17-34.
  13. Ferrie, A.M., V. Goral, C. Wang and Y. Fang, 2015. Label-free functional selectivity assays. Methods Mol. Biol., 1272: 227-246.
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  14. Fang, Y., T. Kenakin and C. Liu, 2015. Editorial: Orphan GPCRs as emerging drug targets. Front. Pharmacol., .
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  15. Fang, Y., 2015. Total internal reflection fluorescence quantification of receptor pharmacology. Biosens., 5: 223-240.
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  16. Fang, Y., 2015. Label-free chemical and phenotypic profiling of living cells. Sci. Lett., .
  17. Fang, Y., 2015. Label-free cell phenotypic profiling and screening: techniques, experimental design and data assessment. Methods Pharmacol. Toxicol., 53: 233-252.
  18. Fang, Y., 2015. Label-free biosensor methods in drug discovery. Springer, New York, Pages: 390.
  19. Fang, Y., 2015. Combining label-free cell phenotypic profiling with computational approaches for novel drug discovery. Expert Opin. Drug Discovery, 10: 331-343.
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  20. Fang, Y., 2015. Are label-free investigations the best approach to drug discovery? Future Med. Chem., 7: 1561-1564.
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  21. Chandrasekaran, S., H. Deng and Y. Fang, 2015. PTEN deletion potentiates invasion of colorectal cancer spheroidal cells through 3D Matrigel. Integr. Biol., 7: 324-334.
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  22. Zhang, X., H. Deng, Y. Xiao, X. Xue and A.M. Ferrie, et al., 2014. Label-free cell phenotypic profiling identifies pharmacologically active compounds in two traditional chinese medicinal plants. RSC Adv., 4: 26368-26377.
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  23. Sun, H., Y. Wei, H. Deng, Q. Xiong, M. Li, J. Lahiri and Y. Fang, 2014. Label-free cell phenotypic profiling decodes the composition and signaling of an endogenous ATP-sensitive potassium channel. Sci. Rep., .
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  24. Orgovan, N., B. Kovacs, E. Farkas, B. Szabo, N. Zaytseva, Y. Fang and R. Horvath, 2014. Bulk and surface sensitivity of a resonant waveguide grating imager. Appl. Phys. Lett., .
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  25. Ferrie, A.M., Q. Wu, O.D. Deichmann and Y. Fang, 2014. High frequency resonant waveguide grating imager for assessing drug-induced cardiotoxicity. Appl. Phys. Lett., .
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  26. Ferrie, A.M., H. Sun, N. Zaytseva and Y. Fang, 2014. Divergent label-free cell phenotypic pharmacology of ligands at the overexpressed β2-adrenergic receptors. Sci. Rep., .
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  27. Febles, N.K., A.M. Ferrie and Y. Fang, 2014. Label-free single cell kinetics of the invasion of spheroidal colon cancer cells through 3D matrigel. Anal. Chem., 86: 8842-8849.
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  28. Fang, Y., 2014. Label-free drug discovery. Front. Pharmacol., 5: 52-52.
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  29. Fang, Y., 2014. Label-free cell phenotypic drug discovery. Comb. Chem. High Throughput Screening, 17: 566-578.
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  30. Ahmed, D., H.S. Muddana, M. Lu, J.B. French and A. Ozcelik, et al., 2014. Acoustofluidic chemical waveform generator and switch. Anal. Chem., 86: 11803-11810.
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  31. Zhao, H., J.B. French, Y. Fang and S.J. Benkovic, 2013. The purinosome, a multi-protein complex involved in the de novo biosynthesis of purines in humans. Chem. Commun., 49: 4444-4452.
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  32. Zaytseva, N., J.G. Lynn, Q. Wu, D.J. Mudaliar, H. Sun, P.Q. Kuang and Y. Fang, 2013. Resonant waveguide grating biosensor-enabled label-free and fluorescence detection of cell adhesion. Sens. Actuators B Chem., 188: 1064-1072.
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  33. Morse, M., H. Sun, E. Tran, R. Levenson and Y. Fang, 2013. Label-free integrative pharmacology on-target of opioid ligands at the opioid receptor family. BMC Pharmacol. Toxicol., Vol. 14 10.1186/2050-6511-14-17.
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  34. Ferrie, A.M., C. Wang, H. Deng and Y. Fang, 2013. A label-free optical biosensor with microfluidics identifies an intracellular signalling wave mediated through the β 2-adrenergic receptor. Integr. Biol., 5: 1253-1261.
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  35. Fang, Y., J. French, H. Zhao and S. Benkovic, 2013. G-protein-coupled receptor regulation of de novo purine biosynthesis: a novel druggable mechanism. Biotechnol. Genet. Eng. Rev., 29: 31-48.
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  36. Fang, Y., 2013. Troubleshooting and deconvoluting label-free cell phenotypic assays in drug discovery. J. Pharmacol. Toxicol. Methods, 67: 69-81.
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  37. Fang, Y., 2013. Microfluidic Biosensor Systems for Cell Biology and Drug Discovery. In: Microfluidics: Control, Manipulation and Behavioral Applications, Panzarella, S. and W. Maroni (Eds.). Nova Publishers, USA., pp: 51-78.
  38. Fang, Y., 2013. Label-free whole cell phenotypic diagnostics for cancer. Biosens. Healthcare Hot Top. Future Med., 2013: 54-67.
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  39. Fang, Y., 2013. Label-free cell phenotypic GPCR drug discovery. Adv. Comb. Chem. High Throughput Screening, 1: 84-129.
  40. Fang, Y., 2013. Biosensors: On the origin of label-free cell phenotypic profiles of drug-target interactions. J. Biochips Tissue Chips, .
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  41. Fang, Y. and J. Lahiri, 2013. Breath analysis: biomarkers, nanosensors, and mid-infrared absorption sensors. Chem. Sens., .
  42. Deng, H., H. Sun and Y. Fang, 2013. Label-free cell phenotypic assessment of the biased agonism and efficacy of agonists at the endogenous muscarinic M 3 receptors. J. Pharmacol. Toxicol. Methods, 68: 323-333.
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  43. Deng, H., C. Wang and Y. Fang, 2013. Label-free cell phenotypic assessment of the molecular mechanism of action of epidermal growth factor receptor inhibitors. RSC Adv., 3: 10370-10378.
  44. Deng, H. and Y. Fang, 2013. The three catecholics benserazide, catechol and pyrogallol are GPR35 agonists. Pharmaceuticals, 6: 500-509.
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  45. Chen, M., N.V. Zaytseva, Q. Wu, M. Li and Y. Fang, 2013. Microplate-compatible total internal reflection fluorescence microscopy for receptor pharmacology. Appl. Phys. Lett., .
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  46. Tran, E., H. Sun and Y. Fang, 2012. Dynamic mass redistribution assays decode surface influence on signaling of endogenous purinergic P2Y receptors. Assay Drug Dev. Technol., 10: 37-45.
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  47. Pai, S., F. Verrier, H. Sun, H. Hu, A.M. Ferrie, A. Eshraghi and Y. Fang, 2012. Dynamic mass redistribution assay decodes differentiation of a neural progenitor stem cell. J. Biomolecular Screening, 17: 1180-1191.
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  48. Li, G., F. Lai and Y. Fang, 2012. Modulating cell-cell communication with a high-throughput label-free cell assay. J. Laboratory Autom., 17: 6-15.
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  49. Hu, H., H. Deng and Y. Fang, 2012. Label-free phenotypic profiling identified D-luciferin as a GPR35 agonist. PLoS One, Vol. 7 10.1371/journal.pone.0034934.
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  50. Ferrie, A.M., O.D. Deichmann, Q. Wu and Y. Fang, 2012. High resolution resonant waveguide grating imager for cell cluster analysis under physiological condition. Applied Physics Lett., 100: 223701-223704.
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  51. Fang, Y., 2012. Ligand-receptor interaction platforms and their applications for drug discovery. Expert Opin. Drug Discovery, 7: 969-988.
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  52. Fang, Y., 2012. Biosensors: From biomolecular interaction analysis to cell phenotypic screen and from bench to bedside. J. Biochips Tissue Chips, Vol. 2 10.4172/2153-0777.1000e113.
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  53. Fang, Y. and A.M. Ferrie, 2012. Resonant Waveguide Grating Biosensor for Cancer Signaling. In: Biosensors and Molecular Technologies for Cancer Diagnostics, Herold, K.E. and A. Rasooly (Eds.). Taylor and Francis, USA., pp: 141-154.
  54. Deng, H., J. Hu, H. Hu, M. He and Y. Fang, 2012. Thieno[3,2-b]thiophene-2-carboxylic acid derivatives as GPR35 agonists. Bioorganic Med. Chem. Lett., 22: 4148-4152.
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  55. Deng, H., H. Hu, S. Ling, A.M. Ferrie and Y. Fang, 2012. Discovery of natural phenols as G protein-coupled receptor-35 (GPR35) agonists. ACS Med. Chem. Lett., 3: 165-169.
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  56. Deng, H., H. Hu and Y. Fang, 2012. Multiple tyrosine metabolites are GPR35 agonists. Sci. Reports, 2: 373-373.
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  57. Deng, H., C. Wang, M. Su and Y. Fang, 2012. Probing biochemical mechanisms of action of muscarinic M3 receptor antagonists with label-free whole cell assays. Anal. Chem., 84: 8232-8239.
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  58. Deng, H. and Y. Fang, 2012. Synthesis and agonistic activity at the GPR35 of 5,6-dihydroxyindole-2-carboxylic acid analogues. ACS Med. Chem. Lett., 3: 550-554.
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  59. Deng, H. and Y. Fang, 2012. Discovery of nitrophenols as GPR35 agonists. Med. Chem. Commun., 3: 1270-1274.
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  60. Deng, H. and Y. Fang, 2012. Aspirin metabolites are GPR35 agonists. Naunyn-Schmiedeberg's Arch. Pharmacol., 385: 729-737.
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  61. Deng, H. and Y. Fang, 2012. Anti-inflammatory gallic acid and wedelolactone are G protein-coupled receptor-35 agonists. Pharmacology, 89: 211-219.
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  62. Zaytseva, N., W. Miller, V. Goral, J. Hepburn and Y. Fang, 2011. Microfluidic resonant waveguide grating biosensor system for whole cell sensing. Appl. Physi. Lett., 10.1063/1.3582611.
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  63. Verrier, F., S. An, A.M. Ferrie, H. Sun, M. Kyoung, Y. Fang and S.J. Benkovic, 2011. GPCRs regulate the assembly of a multienzyme complex for purine biosynthesis. Nature Chem. Biol., 7: 909-915.
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  64. Morse, M., E. Tran, R.L. Levension and Y. Fang, 2011. Ligand-directed functional selectivity at the mu opioid receptor revealed by label-free integrative pharmacology on-target. PLoS One, Vol. 6 10.1371/journal.pone.0025643.
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  65. Goral, V., Y. Jin, H. Sun, A.M. Ferrie, Q. Wu and Y. Fang, 2011. Directed desensitization of the β2-adrenergic receptor. PLoS One, Vol. 6. 10.1371/journal.pone.0019282 -.
  66. Goral, V., Q. Wu, H. Sun and Y. Fang, 2011. Label-free optical biosensor with microfluidics for sensing ligand-directed functional selectivity on trafficking of thrombin receptor. FEBS Lett., 585: 1054-1060.
    PubMed  |  
  67. Ferrie, A.M., H. Sun and Y. Fang, 2011. Label-free integrative pharmacology on-target of drugs at the 2-adrenergic receptor. Sci. Reports, Vol. 1. 10.1038/srep00033.
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  68. Fang, Y., 2011. The development of label-free cellular assays for drug discovery. Expert Opin. Drug Dis., 6: 1285-1298.
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  69. Fang, Y., 2011. Label-free biosensors for cell biology. Int. J. Electrochem. 10.4061/2011/460850.
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  70. Fang, Y., 2011. Air stability of supported lipid membrane spots. Chem. Physics Lett., 512: 258-262.
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  71. Deng, H., H. Hu, M. He, J. Hu, W. Niu, A.M. Ferrie and Y. Fang, 2011. Discovery of 2-(4-methylfuran-2(5H)-ylidene)malononitrile and thieno[3,2-b]thiophene-2-carboxylic acid derivatives as G protein-coupled receptor 35 (GPR35) agonists. J. Med. Chem., 54: 7385-7396.
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  72. Deng, H., H. Hu and Y. Fang, 2011. Tyrphostin analogs are GPR35 agonists. FEBS Lett., 585: 1957-1962.
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  73. Ferrie, A.M., Q. Wu and Y. Fang, 2010. Resonant waveguide grating imager for live cell sensing. Applied Phys. Lett., .
    PubMed  |  
  74. Fang, Y., 2010. Resonant Waveguide Grating Biosensor for Microarrays. In: Optical Guided-Wave Chemical and Biosensors II: Springer Series on Chemical Sensors and Biosensors, Zourob, M. and A. Lakhtakia (Eds.). Vol. 8, Springer-Verlag, Berlin, Heidelberg, pp: 27-42.
  75. Fang, Y., 2010. Probing cancer signaling with resonant waveguide grating biosensors. Expert Opin. Drug Discovery, 5: 1237-1248.
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  76. Fang, Y., 2010. Live cell optical sensing for high throughput applications. Adv. Biochem. Engin. Biotechnol., 118: 153-163.
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  77. Fang, Y., 2010. Label-free receptor assays. Drug Discovery Today Technol., 7: e5-e11.
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  78. Fang, Y., 2010. Label-free biosensor cellular assays for cell adhesion. J. Adhesion Sci. Technol., 24: 1011-1021.
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  79. Fang, Y., 2010. Label-Free Biosensor Cellular Assays for Cell Adhesion. In: Surface and Interfacial Aspects of Cell Adhesion. Carrie, A. and K.L. Mittal (Eds.). CRC Press, Leiden, pp: 155-165.
  80. Wu, M., S. Long, A.G. Frutos, M. Li and Y. Fang, 2009. Interrogation of phosphor-specific interaction on a high-throughput label-free optical biosensor system-Epic® system. J. Receptors Signal Transduct. Res., 29: 202-210.
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  81. Tran, E. and Y. Fang, 2009. Label-free optical biosensor for probing integrative role of adenylyl cyclase in G protein-coupled receptor signaling. J. Receptors Signal Transduct. Res., 29: 154-162.
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  82. Schroder, R., N. Merten, J.M. Mathiesen, L. Martini and A. Kruljac-Letunic et al., 2009. The C-terminal tail of CRTH2 is a key molecular determinant that constrains Gαi and downstream signaling cascade activation. J. Biol. Chem., 284: 1324-1336.
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  83. Fang, Y., J. Fang, E. Tran, X. Xie, M. Hallstrom and A.G. Frutos, 2009. High-Throughput Analysis of Biomolecular Interactions and Cellular Responses with Resonant Waveguide Grating Biosensors. In: Label-Free Biosensors: Techniques and Applications, Matthew, A.C. (Ed.). Cambridge University Press, New York, USA., pp: 206-222.
  84. Fang, Y., A.M. Ferrie and E. Tran, 2009. Resonant waveguide grating biosensor for whole-cell GPCR assays. Meth. Mol. Biol., 552: 239-252.
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  85. Fang, Y., 2009. Guest editor's introduction: Label-free optical biosensors to cell biology and drug discovery. J. Receptors Signal Transduct. Res., 10.1080/10799890903079869.
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  86. Fang, Y. and J. Lahiri, 2009. GPCR microspot assays on solid substrates. Meth. Mol. Biol., 552: 231-238.
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  87. Tran, E. and Y. Fang, 2008. Duplexed label-free G protein-coupled receptor assays for high-throughput screening. J. Biomol. Screen., 13: 975-985.
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  88. Lee, P.H., A. Gao, C. van Staden, J. Ly and J. Salon et al., 2008. Evaluation of dynamic mass redistribution technology for pharmacological studies of recombinant and endogenously expressed G protein-coupled receptors. Assay Drug Develop. Technol., 6: 83-93.
    PubMed  |  
  89. Fang, Y., A.G. Frutos and R. Verklereen, 2008. Label-free cell-based assays for GPCR screening. Combinatorial Chem. High Throughput Screen., 11: 357-369.
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  90. Fang, Y. and A.M. Ferrie, 2008. Label-free optical biosensor for ligand-directed functional selectivity acting on β2 adrenoceptor in living cells. FEBS Lett., 582: 558-564.
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  91. Salon, J., M. Johnson, B. Rasnow, G. Biddlecome, Y. Hong, B. Webb, Y. Fang and J. Lahiri, 2007. G Protein-Coupled Receptor Microarrays for Drug Discovery. In: Functional Protein Microarrays in Drug Discovery, Predki, P.F. (Eds.). CRC Press, New York, pp: 333-349.
  92. Posner, B., Y. Hong, E. Benvenuti, M. Potchoiba and D. Nettleton et al., 2007. Multiplexing G protein-coupled receptors in microarrays: A radioligand-binding assay. Anal. Biochem., 365: 266-273.
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  93. Li, G. and Y. Fang, 2007. Assay optimization and performance evaluation of cell assays with Epic® system and bradykinin B2 receptors in A431 cells. REDLine, 3: e1-e7.
  94. Fang, Y., G. Li and A.M. Ferrie, 2007. Non-invasive optical biosensor for assaying endogenous G protein-coupled receptors in adherent cells. J. Pharmacol. Toxicol. Meth., 55: 314-322.
    PubMed  |  
  95. Fang, Y., A.M. Ferrie, G. Li, F. Verrier and E. Tran et al., 2007. Dynamic mass redistribution: A novel physiological signal of cells for cell systems biology and pharmacology. REDLine, 3: e1-e4.
  96. Fang, Y., A.M. Ferrie and G. Li, 2007. Systems Biology and Pharmacology of B2-Adrenergic Receptors in A431. In: Trends in Signal Transduction Research, Meyers, J.N. (Ed.). Nova Science Publishers, New York, pp: 145-171.
  97. Fang, Y., 2007. Non-invasive optical biosensor for probing cell signaling. Sensors, 7: 2316-2329.
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  98. Fang, Y., 2007. Label-free optical biosensors in drug discovery. Trends Bio Pharmacol. Ind., 3: 34-38.
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  99. Fang, Y. and A.M. Ferrie, 2007. Optical biosensor differentiates signaling of endogenous PAR1 and PAR2 in A431 cells. BMC Cell Biol., Vol. 8. 10.1186/1471-2121-8-24.
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  100. Verkleeren, R., A.G. Frutos, Y. Fang, G. Li and J. Fang, 2006. Physiologically relevant HTS technologies. Genet. Eng. News, .
  101. Verkleeren, R., A.G. Frutos, Y. Fang, G. Li and J. Fang, 2006. A high-throughput label-free screening platform for biochemical and cell-based assays. Am. Biotechnol. Lab., .
  102. Li, G., A.M. Ferrie and Y. Fang, 2006. Label-free profiling of ligands for endogenous GPCRs using a cell-based high-throughput screening technology. J. Associat. Laborat. Automat., 11: 181-187.
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  103. Hong, Y., B.L. Webb, S. Pai, A. Ferrie and J. Peng et al., 2006. Multiplexed compound screening using GPCR microarrays and ligand cocktails. J. Biomol. Screen., 11: 435-438.
  104. Fang, Y., Y. Hong, B.L. Webb and J. Lahiri, 2006. Applications of biomembranes for drug discovery. MRS Bull., 31: 541-545.
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  105. Fang, Y., J. Peng, A.M. Ferrie and R.S. Burkhalter, 2006. Air-stable G protein-coupled receptor microarrays and ligand binding characteristics. Anal. Chem., 78: 149-155.
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  106. Fang, Y., Frutos, A.G., J. Lahiri, D. Bookbinder and D. Chow et al., 2006. Novel Surface Technologies for Genomics, Proteomics and Drug Discovery. In: Frontiers in Biochip Technology, Xing, W.L. and J. Cheng (Eds.). Springer, New York, ISBN-13: 9780387255682, pp: 167-175.
  107. Fang, Y., A.M. Ferrie, N.H. Fontaine, J. Mauro and J. Balakrishnan, 2006. Resonant waveguide grating biosensor for living cell sensing. Biophys. J., 91: 1925-1940.
    PubMed  |  
  108. Fang, Y., A.M. Ferrie, N.H. Fontaine and P.K. Yuen, 2006. Optical biosensors for monitoring dynamic mass redistribution in living cells mediated by epidermal growth factor receptor activation. Proceedings of the 27th Annual International Conference of the Engineering in Medicine and Biology Society, January 17-18, 2005, Shanghai, China, pp: 666-669.
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  109. Fang, Y., A.M. Ferrie and G. Li, 2006. Cellular functions of cholesterol probed with optical biosensors. Biochim. Biophys. Acta Mol. Cell Res., 1763: 254-261.
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  110. Fang, Y., 2006. Spreading and segregation of lipids in air-stable lipid microarrays. J. Am. Chem. Soc., 128: 3158-3159.
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  111. Fang, Y., 2006. Label-free cell-based assays with optical biosensors in drug discovery. Assay Drug Develop. Technol., 4: 583-595.
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  112. Hong, Y., B.L. Webb, H. Su, E.J. Mozdy and Y. Fang et al., 2005. Functional GPCR microarrays. J. Am. Chem. Soc., 127: 15350-15351.
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  113. Fang, Y., G.G. Li and J. Peng, 2005. Optical biosensor provides insights for bradykinin B2 receptor signaling in A431 cells. FEBS Lett., 579: 6365-6374.
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  114. Fang, Y., A.M. Ferrie, N.H. Fontaine and P.K. Yuen, 2005. Characteristics of dynamic mass redistribution of epidermal growth factor receptor signaling in living cells measured with label-free optical biosensors. Anal. Chem., 77: 5720-5725.
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  115. Fang, Y., A.M. Ferrie and G. Li, 2005. Probing cytoskeleton modulation by optical biosensors. FEBS Lett., 579: 4175-4180.
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  116. Fang, Y., A.M. Ferrie and F. Lai, 2005. Production of protein microarrays using robotic pin printing technologies. In: The Proteomics Protocols Handbook, Humana Press, Walker, J.M. (Ed.). Totowa, New Jersey, ISBN-13: 9781588293435, pp: 723-733.
  117. Fang, Y., A.G. Frutos, Y. Hong and J. Lahiri, 2005. Biological Membrane Microarrays. In: Microarray Technology and Its Applications, Muller, U.R. and D.V. Nicolau (Ed.). Springer, Berlin Heidelberg, Germany, ISBN-13: 9783540229315, pp: 309-320.
  118. Fang, Y., Y. Hong, J. Peng and J. Lahiri, 2004. G-Protein Coupled Receptor Microarrays: A Versatile Tool for Drug Discovery. In: Protein Microarrays, Schena, M. (Ed.). Jones and Bartlett Publishers, UK., pp: 377-385.
  119. Fang, Y., B. Webb, Y. Hong, A. Ferrie, F. Lai, A.G. Frutos and J. Lahiri, 2004. Fabrication and Application of G Protein-Coupled Receptor Microarrays. In: Protein Arrays, Fung, E.T. (Ed.). Humana Press, Totowa, New Jersey, ISBN-13: 9781588292551, pp: 233-243.
  120. Fang, Y., J. Lahiri and L. Picard, 2003. G protein-coupled receptor microarrays for drug discovery. Drug Discovery Today, 8: 755-761.
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  121. Fang, Y., A.G. Frutos and J. Lahiri, 2003. Ganglioside microarrays for toxin detection. Langmuir, 19: 1500-1505.
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  122. Fang, Y., A.G. Frutos, B. Webb, Y. Hong, A. Ferrie, F. Lai and J. Lahiri, 2002. Membrane biochips. Biotechniques, 33: S62-S65.
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  123. Fang, Y., A.G. Frutos and J. Lahiri, 2002. Membrane protein microarrays. J. Am. Chem. Soc., 124: 2394-2395.
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  124. Fang, Y., A.G. Frutos and J. Lahiri, 2002. G-Protein-coupled receptor microarrays. Chembiochem, 3: 987-991.
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  125. Fang, Y., A.G. Frutos and J. Lahiri, 2002. G protein-coupled receptor (GPCR) microarrays. Proceedings of the SPIE 4626, Biomedical Nanotechnology Architectures and Applications, June 19, 2002, San Jose, CA., USA., pp: 98-102.
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  126. Lahiri, J., S.J. Jonas, A.G. Frutos, P. Kalal and Y. Fang, 2001. Lipid microarrays. Biom. Microdevices, 3: 157-164.
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  127. Fang, Y. and J.H. Hoh, 2001. Characterization of DNA condensates by atomic force microscopy. Nonviral Vectors Gene Ther. Methods Protoc., 2001: 149-158.
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  128. Fang, Y., J.H. Hoh and T.S. Spisz, 1999. Ethanol-induced structural transitions of DNA on mica. Nucl. Acids Res., 27: 1943-1949.
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  129. Fang, Y. and J.H. Hoh, 1999. Cationic silanes stabilize intermediates in DNA condensation. FEBS Lett., 459: 173-176.
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  130. Spisz, M.T., Y. Fang, R.H. Reeves, C.K. Seymour, I.N. Bankman and J.H. Hoh, 1998. Automated sizing of DNA fragments in atomic force microscope images. Med. Biol. Eng. Comput., 36: 667-672.
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  131. Fang, Y., T.S., Spisz T. Wiltshire, N.P. D'Costa, I.N. Bankman, R.H. Reeves and J.H. Hoh, 1998. Solid-state DNA sizing by atomic force microscopy. Anal. Chem., 70: 2123-2129.
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  132. Fang, Y. and J.H. Hoh, 1998. Surface-directed DNA condensation in the absence of soluble multivalent cations. Nucleic Acids Res., 26: 588-593.
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  133. Fang, Y. and J.H. Hoh, 1998. Early intermediates in spermidine-induced DNA condensation on the surface of mica. J. Am. Chem. Soc., 120: 8903-8909.
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  134. Fang, Y., Y. Wei, C. Bai, Y. Tang, S.B. Lin and L.S. Kan, 1997. Hydrated water molecules of pyrimidine/purine/pyrimidine DNA triple helices as revealed by FT-IR spectroscopy: A role of cytosine methylation. J. Biomol. Struct. Dyn., 14: 485-493.
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  135. Fang, Y., S. Cheley, H. Bayley and J. Yang, 1997. The heptameric prepore of a staphylococcal α-hemolysin mutant in lipid bilayers imaged by atomic force microscopy. Biochemistry, 36: 9518-9522.
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  136. Fang, Y. and J. Yang, 1997. Two-dimensional condensation of DNA molecules on cationic lipid membranes. J. Phys. Chem. B, 101: 441-449.
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  137. Fang, Y. and J. Yang, 1997. The growth of bilayer defects and the induction of interdigitated domains in the lipid-loss process of supported phospholipid bilayers. Biochim. Biophys. Acta, 1324: 309-319.
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  138. Fang, Y. and J. Yang, 1997. Effect of cationic strength and species on 2-D condensation of DNA. J. Phys. Chem. B, 101: 3453-3456.
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  139. Fang, Y., Y. Wei, C. Bai and L.S. Kan, 1996. Surface-Enhanced Fourier Transform Raman Scattering from a DNA Triple Helix Poly [dA]. 2Poly [dT] at a silver electrode: Beyond the short-range mechanism. J. Phys. Chem., 100: 17410-17413.
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  140. Fang, Y., C. Bai, Y. Wei and Y. Tang, 1996. Surface-enhanced Fourier transform Raman scattering study on the adsorption structure of an RNA triple helix at a silver electrode. Applied Spectrosc., 50: 48-52.
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  141. Fang, Y., C. Bai, T. Wang, F. Zhong, Y.Q. Tang, S.B. Lin and L.S. Kan, 1996. Evidence of the conformational rigidity of triplex d(CT)8.d(AG) 8.d(CT) 8 on silver electrode revealed by Fourier transform Raman scattering studies. J. Mol. Struct., 377: 1-11.
  142. Fang, Y. and J. Yang, 1996. Role of the bilayer-bilayer interaction on the ripple structure of supported bilayers in solution. J. Phys. Chem., 100: 15614-15619.
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  143. Zhang, P.C., C. Bai, Y.M. Huang, H. Zhao, Y. Fang, N.X. Wang and Q. Li, 1995. Atomic force microscopy study of fine structures of the entire surface of red blood cells. Scanning Microsc., 9: 981-988.
    PubMed  |  
  144. Fang, Y., C. Bai, Y. Wei, Y. Tang, S.B. Lin and L.S. Kan, 1995. Determination of the conformations of intramolecular DNA triple helices by FT-IR spectroscopy: Effect of loop length. J. Mol. Struct., 372: 241-247.
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  145. Fang, Y., C. Bai, Y. Wei, S.B. Lin and L.S. Kan, 1995. Effect of selective cytosine methylation and hydration on the conformations of DNA triple helices containing a TTTT loop structure by FT-IR spectroscopy. J. Biomol. Struct. Dyn., 13: 471-482.
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  146. Fang, Y., C. Bai, P.C. Zhang, E.H. Cao, Y.J. He and Y.Q. Tang, 1994. Interaction of ethidium bromide with a triplex DNA dA10.2dT10. Sci. China B, 37: 1306-1312.