Dr. Donovan C. Haines
Associate ProfessorSam Houston State University, USA
Highest Degree
PostDoc Fellow in Biochemistry and Biophysics from University of Texas Southwestern Medical Center, Dallas, Texas, USA
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Sam Houston State University, USA
Biography
Dr. Donovan C. Haines holds a position of Associate Professor at Sam Houston State University, USA. He has completed his Ph.D. in Chemistry from Wichita State University, USA. Previously he was appointed as Graduate Research Assistant, Graduate Teacher Assistant at Wichita State University, Wichita, KS, and Postdoctoral Researcher at University of Texas Southwestern Medical Center at Dallas, Dallas, TX. He has 23 publications in peer review journals and 21 presentations contributed as author/co-author. He also received number of grants for research work. He also served as member of many committees and reviewer for many journals.
Area of Interest:
Chemistry
100%
Organic Synthesis
62%
Biochemistry
90%
Biophysics
75%
Kinetics
55%
Research Publications in Numbers
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Selected Publications
- Marziaz, M.L., K. Frazier, P.B. Guidry, R.A. Ruiz, I. Petrikovics and D.C. Haines, 2013. Comparison of brain mitochondrial cytochrome c oxidase activity with cyanide LD50 yields insight into the efficacy of prophylactics. J. Applied Toxicol., 33: 50-55.
CrossRef | PubMed | Direct Link | - Davydov, D.R., G.V. Ponomarev, E. Bobrovnikova‐Marjon, D.C. Haines and J.A. Peterson, 2013. Aluminum-substituted heme domain of P450BM-3 (BMP): Introducing a heme-derived fluorescent probe for studies of substrate binding and protein-protein interactions in cytochromes P450. Biotechnol. Applied Biochem., 60: 41-51.
CrossRef | - De Matteis, F., D.P. Ballou, M.J. Coon, R.W. Estabrook and D.C. Haines, 2012. Peroxidase-like activity of uncoupled cytochrome P450: Studies with bilirubin and toxicological implications of uncoupling. Biochem. Pharmacol., 84: 374-382.
CrossRef | Direct Link | - Haines, D.C., A. Hegde, B. Chen, W. Zhao and M. Bondlela et al., 2011. A single active-site mutation of P450BM-3 dramatically enhances substrate binding and rate of product formation. Biochemistry, 50: 8333-8341.
CrossRef | Direct Link | - Horke, S., I. Witte, S. Altenhofer, P. Wilgenbus and M. Goldeck et al., 2010. Paraoxonase 2 is down-regulated by the Pseudomonas aeruginosa quorumsensing signal N-(3-oxododecanoyl)-L-homoserine lactone and attenuates oxidative stress induced by pyocyanin. Biochem. J., 426: 73-83.
CrossRef | Direct Link | - Teiber, J.F., S. Horke, D.C. Haines, P.K. Chowdhary and J. Xiao et al., 2008. Dominant role of paraoxonases in inactivation of the Pseudomonas aeruginosa quorum-sensing signal N-(3-oxododecanoyl)-L-homoserine lactone. Infect. Immunity, 76: 2512-2519.
CrossRef | Direct Link | - Haines, D.C., B. Chen, D.R. Tomchick, M. Bondlela, A. Hegde, M. Machius and J.A. Peterson, 2008. Crystal structure of inhibitor-bound P450BM-3 reveals open conformation of substrate access channel. Biochemistry, 47: 3662-3670.
CrossRef | Direct Link | - Chowdhary, P.K., L. Stewart, C. Lopez and D.C. Haines, 2008. A single mutation in P450BM-3 enhances acyl homoserine lactone: Acyl homoserine substrate binding selectivity nearly 250-fold. J. Biotechnol., 135: 374-376.
CrossRef | Direct Link | - Kitazume, T., D.C. Haines, R.W. Estabrook, B. Chen and J.A. Peterson, 2007. Obligatory intermolecular electron-transfer from FAD to FMN in dimeric P450BM-3. Biochemistry, 46: 11892-11901.
CrossRef | Direct Link | - Hegde, A., D.C. Haines, M. Bondlela, B. Chen and N. Schaffer et al., 2007. Interactions of substrates at the surface of P450s can greatly enhance substrate potency. Biochemistry, 46: 14010-14017.
CrossRef | PubMed | Direct Link | - Chowdhary, P.K., N. Keshavan, H.Q. Nguyen, J.A. Peterson, J.E. Gonzalez and D.C. Haines, 2007. Bacillus megaterium CYP102A1 oxidation of acyl homoserine lactones and acyl homoserines. Biochemistry, 46: 14429-14437.
CrossRef | - Chowdhary, P.K., M. Alemseghed and D.C. Haines, 2007. Cloning, expression and characterization of a fast self-sufficient P450: CYP102A5 from Bacillus cereus. Arch. Biochem. Biophys., 468: 32-43.
CrossRef | Direct Link | - Haines, D.C., 2006. A role for the strained phenylalanine ring rotation induced by substrate binding to cytochrome CYP102A1. Protein Peptide Lett., 13: 977-980.
CrossRef | Direct Link | - Kou, W., H.S. Kolla, A. Ortiz-Acevedo, D.C. Haines, M. Junker and G.R. Dieckmann, 2005. Modulation of zinc- and cobalt-binding affinities through changes in the stability of the zinc ribbon protein L36. J. Biol. Inorg. Chem., 10: 167-180.
CrossRef | Direct Link | - Keshavan, N.D., P.K. Chowdhary, D.C. Haines and J.E. Gonzalez, 2005. L-canavanine made by Medicago sativa interferes with quorum sensing in Sinorhizobium meliloti. J. Bacteriol., 187: 8427-8436.
CrossRef | Direct Link | - Wanduragala, S., D.S. Wimalasena, D.C. Haines, P.K. Kahol and K. Wimalasena, 2003. pH-induced alteration and oxidative destruction of heme in purified chromaffin granule cytochrome b561: Implications for the oxidative stress in catecholaminergic neurons. Biochemistry, 42: 3617-3626.
CrossRef | Direct Link | - Wimalasena, D.S., S.P. Jayatillake, D.C. Haines, K. Wimalasena and K. Wimalasena, 2002. Plausible molecular mechanism for fumarate activation and electron transfer of the dopamine β-monooxygenase reaction. Biochem. J., 367: 77-85.
CrossRef | PubMed | Direct Link | - Haines, D.C., D.R. Tomchick, M. Machius and J.A. Peterson, 2001. Pivotal role of water in the mechanism of P450BM-3. Biochemistry, 40: 13456-13465.
CrossRef | Direct Link | - Falck, J.R., Y.K. Reddy, D.C. Haines, K.M. Reddy and U.M. Krishna et al., 2001. Practical, enantiospecific syntheses of 14, 15-EET and leukotoxin B (vernolic acid). Tetrahedron Lett., 42: 4131-4133.
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