Dr. Igor  L. Medintz
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Dr. Igor L. Medintz

Research Scientist
U.S. Naval Research Laboratory, USA


Highest Degree
Ph.D. in Biology from City University of New York, USA

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Biography

Dr. Igor L. Medintz is currently a Research Biologist and Head of the Laboratory for Bio/Nano Science and Technology which is part of the Center for Bio/Molecular Science and Engineering of the U.S. Naval Research Laboratory in Washington, D.C. He is also an Adjunct Associate Professor, Fischell Department of Bioengineering, A. James Clark School of Engineering and an NRL Postdoctoral Research Associate Program Mentor. His previous work experience includes Affiliate Professor, Department of Molecular & Microbiology, Life Sciences, George Mason University, National Research Council Postdoctoral Fellow, Staff Scientist at Vertex Pharmaceuticals, Forensic Toxicologist, Graduate Research Assistant and Research Associate in different laboratories, Lecturer and Instructor at different institutions. He obtained his PhD degree in Molecular Biology in February 1999 from the Graduate School and University Center of the City University of New York. He has published 178 research articles related to his field in refereed national and international journals (Google Scholar Citations >18,000 h-index 60), proceedings (54), books (3) and 18 chapters in books. He actively participated and presented (Orally and Poster) number of articles in seminars, conferences, symposiums and meetings. He also possess 15 patents. He is an active Reviewer and Editorial Advisory Board Member to several journals and a Scientific Advisory Board to several European Consortium projects. He was been honored by a number of Awards including the Top Scientist in the Navy. He also served as a PhD Examiner and Promotion Reviewer for several students and professors. (PhD Thesis Examiner, Tenure Review Evaluation, External Reviewer, Thesis Advisory Committee & External reviewer for promotion evaluation).

Area of Interest:

Physics
100%
Nanomaterials
62%
Enzyme Activity
90%
Nanoparticles
75%
Energy Transfer
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
0
Abstracts
0

Selected Publications

  1. Walper, S.A., K.B. Turner and I.L. Medintz, 2015. Enzymatic bioconjugation of nanoparticles: Developing specificity and control. Curr. Opin. Biotechnol., 34: 232-241.
    CrossRef  |  Direct Link  |  
  2. Spillmann, C.M. and I.L. Medintz, 2015. Use of biomolecular scaffolds for assembling multistep light harvesting and energy transfer devices. J. Photochem. Photobiol. C: Photochem. Rev., 23: 1-24.
    CrossRef  |  Direct Link  |  
  3. Samanta, A., S.A. Walper, K. Susumu, C.L. Dwyer and I.L. Medintz, 2015. An enzymatically-sensitized sequential and concentric energy transfer relay self-assembled around semiconductor quantum dots. Nanoscale, 7: 7603-7614.
    CrossRef  |  Direct Link  |  
  4. Massey, M., M.G. Ancona, I.L. Medintz and W.R. Algar, 2015. Time-gated DNA photonic wires with forster resonance energy transfer cascades initiated by a luminescent terbium donor. ACS Photonics, 2: 639-652.
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  5. Field, L.D., J.B. Delehanty, Y.C. Chen and I.L. Medintz, 2015. Peptides for specifically targeting nanoparticles to cellular organelles: Quo vadis? Accounts Chem. Res., 48: 1380-1390.
    CrossRef  |  Direct Link  |  
  6. Ding, S., A.A. Cargill, I.L. Medintz and J.C. Claussen, 2015. Increasing the activity of immobilized enzymes with nanoparticle conjugation. Curr. Opin. Biotechnol., 34: 242-250.
    CrossRef  |  PubMed  |  Direct Link  |  
  7. Claussen, J.C., A. Malanoski, J.C. Breger, E. Oh and S.A. Walper et al., 2015. Probing the enzymatic activity of alkaline phosphatase within quantum dot bioconjugates. J. Phys. Chem. C, 119: 2208-2221.
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  8. Breger, J.C., S.A. Walper, E. Oh, K. Susumu, M.H. Stewart, J.R. Deschamps and I.L. Medintz, 2015. Quantum dot display enhances activity of a phosphotriesterase trimer. Chem. Commun., 51: 6403-6406.
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  9. Breger, J., J.B. Delehanty and I.L. Medintz, 2015. Continuing progress toward controlled intracellular delivery of semiconductor quantum dots. WIREs Nanomed. Nanobiotechnol., 7: 131-151.
    CrossRef  |  Direct Link  |  
  10. Agarwal, R., M. Domowicz, N. Schwartz, J. Henry and I.L. Medintz et al., 2015. Delivery and tracking of quantum dot peptide bioconjugates in an intact developing avian brain. ACS Chem. Neurosci., 6: 494-504.
    CrossRef  |  Direct Link  |  
  11. Wegner, K.D., F. Morgner, E. Oh, R. Goswami and K. Susumu et al., 2014. Three-dimensional solution-phase forster resonance energy transfer analysis of nanomolar quantum dot bioconjugates with subnanometer resolution. Chem. Mater., 26: 4299-4312.
    CrossRef  |  Direct Link  |  
  12. Susumu, K., E. Oh, J.B. Delehanty, F. Pinaud and K.B. Gemmill et al., 2014. A new family of pyridine-appended multidentate polymers as hydrophilic surface ligands for preparing stable biocompatible quantum dots. Chem. Mater., 26: 5327-5344.
    CrossRef  |  Direct Link  |  
  13. Spillmann, C.M., S. Buckhout-White, E. Oh, E.R. Goldman, M.G. Ancona and I.L. Medintz, 2014. Extending FRET cascades on linear DNA photonic wires. Chem. Commun., 50: 7246-7249.
    CrossRef  |  Direct Link  |  
  14. Spillmann, C.M., J. Naciri, W.R. Algar, I.L. Medintz and J.B. Delehanty, 2014. Multifunctional liquid crystal nanoparticles for intracellular fluorescent imaging and drug delivery. ACS Nano, 8: 6986-6997.
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  15. Scott, A.M., W.R. Algar, M.H. Stewart, S. Trammell and J. Blanco-Canosa et al., 2014. Probing the quenching of quantum dot photoluminescence by peptide-labeled ruthenium(II) complexes. J. Phys. Chem. C, 118: 9239-9250.
    CrossRef  |  Direct Link  |  
  16. Nazarenus, M., Q. Zhang, M.G. Soliman, P. del Pino and B. Pelaz et al., 2014. In vitro interaction of colloidal nanoparticles with mammalian cells: What have we learned thus far? Beilstein J. Nanotechnol., 5: 1477-1490.
    Direct Link  |  
  17. Nagy, A., K.B. Gemmill, J.B. Delehanty, I.L. Medintz and K.E. Sapsford, 2014. Peptide-functionalized quantum dot biosensors. IEEE J. Selected Topics Quantum Electron., Vol. 20. 10.1109/JSTQE.2013.2284427.
    CrossRef  |  Direct Link  |  
  18. Johnson, B.J., W.R. Algar, A.P. Malanoski, M.G. Ancona and I.L. Medintz, 2014. Understanding enzymatic acceleration at nanoparticle interfaces: Approaches and challenges. Nano Today, 9: 102-131.
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  19. Cunningham, P., A. Khachatrian, S. Buckhout-White, J.R. Deschamps, E.R. Goldman, I.L. Medintz and J.S. Melinger, 2014. Resonance energy transfer in DNA duplexes labeled with localized dyes. J. Phys. Chem. B, 118: 14555-14565.
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  20. Claussen, J.C., N. Hildebrandt, K. Susumu, M.G. Ancona and I.L. Medintz, 2014. Complex logic functions implemented with quantum dot bionanophotonic circuits. ACS Applied Mater. Interfaces, 6: 3771-3778.
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  21. Claussen, J.C., M.A. Daniele, J. Geder, M. Pruessner and A.J. Makinen et al., 2014. Platinum-paper micromotors: An urchin-like nanohybrid catalyst for green monopropellant bubble-thrusters. ACS Applied Mater. Interfaces, 6: 17837-17847.
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  22. Buckhout-White, S., J.C. Claussen, J.S. Melinger, Z. Dunningham, M.G. Ancona, E.R. Goldman and I.L. Medintz, 2014. A triangular three-dye DNA switch capable of reconfigurable molecular logic. RSC Adv., 4: 48860-48871.
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  23. Buckhout-White, S., C.M. Spillmann, W.R. Algar, A. Khachatrian and J.S. Melinger et al., 2014. Assembling programmable FRET-based photonic networks using designer DNA scaffolds. Nat. Commun., Vol. 5. 10.1038/ncomms6615.
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  24. Breger, J.C., K.E. Sapsford, J. Ganek, K. Susumu, M.H. Stewart and I.L. Medintz, 2014. Detecting kallikrein proteolytic activity with peptide-quantum dot nanosensors. ACS Applied Mater. Interfaces, 6: 11529-11535.
    CrossRef  |  Direct Link  |  
  25. Blanco-Canosa, J.B., M. Wu, K. Susumu, E. Petryayeva and T.L. Jennings et al., 2014. Recent progress in the bioconjugation of quantum dots. Coordination Chem. Rev., 263: 101-137.
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  26. Andrasfalvy, B.K., G.L. Galinanes, D. Huber, M. Barbic and J.J. Macklin et al., 2014. Quantum dot-based multiphoton fluorescent pipettes for targeted neuronal electrophysiology. Nat. Methods, 11: 1237-1241.
    CrossRef  |  Direct Link  |  
  27. Algar, W.R., M.H. Stewart, A.M. Scott, W.J. Moon and I.L. Medintz, 2014. Quantum dots as platforms for charge transfer-based biosensing: Challenges and opportunities. J. Mater. Chem. B, 2: 7816-7827.
    CrossRef  |  Direct Link  |  
  28. Algar, W.R., H. Kim, I.L. Medintz and N. Hildebrandt, 2014. Emerging non-traditional forster resonance energy transfer configurations with semiconductor quantum dots: Investigations and applications. Coordination Chem. Rev., 263-264: 65-85.
    CrossRef  |  Direct Link  |  
  29. Stewart, M.H., A. Huston, A. Scott, E. Oh and W.R. Algar et al., 2013. Competition between FRET and electron transfer in stoichiometrically-assembled quantum dot-fullerene conjugates. ACS Nano, 7: 9489-9505.
  30. Spillmann, C.M., M.G. Ancona, S. Buckhout-White, W.R. Algar and M.H. Stewart et al., 2013. Achieving effective terminal exciton delivery in quantum dot antenna-sensitized multistep DNA photonic wires. ACS Nano, 7: 7101-7118.
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  31. Sapsford, K.E., W.R. Algar, L. Berti, K.B. Gemmill and B.J. Casey et al., 2013. Functionalizing nanoparticles with biological molecules: Developing chemistries that facilitate nanotechnology. Chem. Rev., 113: 1904-2074.
    CrossRef  |  Direct Link  |  
  32. Petryayeva, E., I.L. Medintz and W.R. Algar, 2013. Quantum dots in bioanalysis: A review of applications across various platforms for fluorescence spectroscopy and imaging. Applied Spectrosc., 67: 215-252.
    Direct Link  |  
  33. Oh, E., K. Susumu, A.J. Makinen, J.R. Deschamps, A.L. Huston and I.L. Medintz, 2013. Colloidal stability of gold nanoparticles coated with multithiol-poly (ethylene glycol) ligands: importance of structural constraints of the sulfur anchoring groups. J. Phys. Chem. C, 117: 18947-18956.
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  34. Oh, E., F.K. Fatemi, M. Currie, J.B. Delehanty and T. Pons et al., 2013. PEGylated luminescent gold nanoclusters: Synthesis, characterization, bioconjugation and application to one‐and two‐photon cellular imaging. Particle Particle Syst. Characterization, 30: 453-466.
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  35. Medintz, I.L., 2013. Chemosensors-welcome to a new open access journal intended to cover all aspects of chemical sensing. Chemosensors, 1: 1-2.
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  36. Gemmill, K.B., M. Muttenthaler, J.B. Delehanty, M.H. Stewart, K. Susumu, P.E. Dawson and I.L. Medintz, 2013. Evaluation of diverse peptidyl motifs for cellular delivery of semiconductor quantum dots. Anal. Bioanal. Chem., 405: 6145-6154.
    CrossRef  |  Direct Link  |  
  37. Gemmill, K.B., J.R. Deschamps, J.B. Delehanty, K. Susumu and M.H. Stewart et al., 2013. Optimizing protein coordination to quantum dots with designer peptidyl linkers. Bioconjugate Chem., 24: 269-281.
    CrossRef  |  Direct Link  |  
  38. Delehanty, J.B., J.C. Breger, K.B. Gemmill, M.H. Stewart and I.L. Medintz, 2013. Controlling the actuation of therapeutic nanomaterials: Enabling nanoparticle-mediated drug delivery. Therapeutic Delivery, 4: 1411-1429.
    CrossRef  |  Direct Link  |  
  39. Delehanty, J.B., J.B. Blanco-Canosa, C.E. Bradburne, K. Susumu and M.H. Stewart et al., 2013. Site-specific cellular delivery of quantum dots with chemoselectively-assembled modular peptides. Chem. Commun., 49: 7878-7880.
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  40. Delehanty, J.B. and I.L. Medintz, 2013. Controlled actuation of therapeutic nanoparticles: Moving beyond passive delivery modalities. Therapeutic Delivery, 4: 127-129.
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  41. Claussen, J.C., W.R. Algar, N. Hildebrandt, K. Susumu, M.G. Ancona and I.L. Medintz, 2013. Biophotonic logic devices based on quantum dots and temporally-staggered Forster energy transfer relays. Nanoscale, 5: 12156-12170.
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  42. Buckhout-White, S., J.T. Robinson, N.D. Bassim, E.R. Goldman, I.L. Medintz and M.G. Ancona, 2013. TEM imaging of unstained DNA nanostructures using suspended graphene. Soft Matter., 9: 1414-1417.
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  43. Bradburne, C.E., J.B. Delehanty, K.B. Gemmill, B.C. Mei and H. Mattoussi et al., 2013. Cytotoxicity of quantum dots used for in vitro cellular labeling: Role of QD surface ligand, delivery modality, cell type and direct comparison to organic fluorophores. Bioconjugate Chem., 24: 1570-1583.
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  44. Boeneman, K., J.B. Delehanty, J.B. Blanco-Canosa, K. Susumu and M.H. Stewart et al., 2013. Selecting improved peptidyl motifs for cytosolic delivery of disparate protein and nanoparticle materials. ACS Nano, 7: 3778-3796.
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  45. Anderson, G.P., R.H. Glaven, W.R. Algar, K. Susumu, M.H. Stewart, I.L. Medintz and E.R. Goldman, 2013. Single domain antibody-quantum dot conjugates for ricin detection by both fluoroimmunoassay and surface plasmon resonance. Anal. Chim. Acta, 786: 132-138.
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  46. Algar, W.R. and I.L. Medintz, 2013. Concentric energy transfer with quantum dots for multiplexed biosensing. Nano Rev., Vol. 4. 10.3402/nano.v4i0.22428.
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  47. Walters, R., R.P. Kraig, I. Medintz, J.B. Delehanty and M.H. Stewart et al., 2012. Nanoparticle targeting to neurons in a rat hippocampal slice culture model. ASN Neuro, 4: 383-392.
    PubMed  |  
  48. Stewart, M.H., A.L. Huston, A.M. Scott, A.L. Efros and J.S. Melinger et al., 2012. Complex forster energy transfer interactions between semiconductor quantum dots and a redox-active osmium assembly. ACS Nano, 6: 5330-5347.
    CrossRef  |  Direct Link  |  
  49. Hotzer, B., I.L. Medintz and N. Hildebrandt, 2012. Fluorescence in nanobiotechnology: Sophisticated fluorophores for novel applications. Small, 8: 2297-2326.
    CrossRef  |  Direct Link  |  
  50. Delehanty, J.B., K. Susumu, R.L. Manthe, W.R. Algar and I.L. Medintz, 2012. Active cellular sensing with quantum dots: Transitioning from research tool to reality: A review. Anal. Chim. Acta, 750: 63-81.
    CrossRef  |  Direct Link  |  
  51. Delehanty, J.B. and I.L. Medintz, 2012. Elaborate nanoparticle-based traps for catching cytosolic players in the act. ChemBioChem, 13: 30-33.
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  52. Claussen, J.C. and I.L. Medintz, 2012. Using nanotechnology to improve lab on a chip devices. J. Biochips Tissue Chips, Vol. 2. .
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  53. Buckhout-White, S., M. Ancona, E. Oh, J.R. Deschamps and M.H. Stewart et al., 2012. Multimodal characterization of a linear DNA-based nanostructure. ACS Nano, 6: 1026-1043.
    CrossRef  |  Direct Link  |  
  54. Algar, W.R., M.G. Ancona, A.P. Malanoski, K. Susumu and I.L. Medintz, 2012. Assembly of a concentric forster resonance energy transfer relay on a quantum dot scaffold: Characterization and application to multiplexed protease sensing. ACS Nano, 6: 11044-11058.
    CrossRef  |  Direct Link  |  
  55. Algar, W.R., D. Wegner, A.L. Huston, J.B. Blanco-Canosa and M.H. Stewart et al., 2012. Quantum dots as simultaneous acceptors and donors in time-gated forster resonance energy transfer relays: Characterization and biosensing. J. Am. Chem. Soc., 134: 1876-1891.
    CrossRef  |  Direct Link  |  
  56. Algar, W.R., A.P. Malanoski, K. Susumu, M.H. Stewart, N. Hildebrandt and I.L. Medintz, 2012. Multiplexed tracking of protease activity using a single color of quantum dot vector and a time-gated Forster resonance energy transfer relay. Anal. Chem., 84: 10136-10146.
    CrossRef  |  Direct Link  |  
  57. Algar, W.R., A. Malonoski, J.R. Deschamps, J.B. Blanco-Canosa and K. Susumu et al., 2012. Proteolytic activity at quantum dot-conjugates: Kinetic analysis reveals enhanced enzyme activity and localized interfacial "Hopping". Nano Lett., 12: 3793-3802.
    CrossRef  |  Direct Link  |  
  58. Susumu, K., E. Oh, J.B. Delehanty, J.B. Blanco-Canosa and B.J. Johnson et al., 2011. Multifunctional compact zwitterionic ligands for preparing robust biocompatible semiconductor quantum dots and gold nanoparticles. J. Am. Chem. Soc., 133: 9480-9496.
    CrossRef  |  Direct Link  |  
  59. Sapsford, K.E., S. Spindel, T.L. Jennings, G. Tao, R.C. Triulzi, W.R. Algar and I.L. Medintz, 2011. Optimizing two-color semiconductor nanocrystal immunoassays in single well microtiter plate formats. Sensors, 11: 7879-7891.
    CrossRef  |  Direct Link  |  
  60. Sapsford, K.E., K.M. Tyner, B.J. Dair, J.R. Deschamps and I.L. Medintz, 2011. Analyzing nanomaterial bioconjugates: A review of current and emerging purification and characterization techniques. Anal. Chem., 83: 4453-4488.
    CrossRef  |  Direct Link  |  
  61. Sapsford, K.E., J. Granek, J.R. Deschamps, K. Boeneman and J.B. Blanco-Canosa et al., 2011. Monitoring botulinum neurotoxin A activity with peptide-functionalized quantum dot resonance energy transfer sensors. ACS Nano, 5: 2687-2699.
    CrossRef  |  Direct Link  |  
  62. Pons, T., I.L. Medintz, D. Farrell, X. Wang and A.F. Grimes et al., 2011. Single-molecule colocalization studies shed light on the idea of fully emitting versus dark single quantum dots. Small, 7: 2101-2108.
    CrossRef  |  Direct Link  |  
  63. Oh, E., J.B. Delehanty, K.E. Sapsford, K. Susumu and R. Goswami et al., 2011. Cellular uptake and fate of PEGylated gold nanoparticles is dependent on both cell-penetration peptides and particle size. ACS Nano, 5: 6434-6448.
    CrossRef  |  Direct Link  |  
  64. Morgner, F., S. Stufler, D. Geibler, I.L. Medintz and W.R. Algar et al., 2011. Terbium to quantum dot FRET bioconjugates for clinical diagnostics: Influence of human plasma on optical and assembly properties. Sensors, 11: 9667-9684.
    CrossRef  |  Direct Link  |  
  65. Jennings, T.L., S.G. Becker-Catania, R.C. Triulzi, G. Tao and B. Scott et al., 2011. Reactive semiconductor nanocrystals for chemoselective biolabeling and multiplexed analysis. ACS Nano, 5: 5579-5593.
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  66. Delehanty, J.B., C.E. Bradburne, K. Susumu, K. Boeneman and B.C. Mei et al., 2011. Spatiotemporal multicolor labeling of individual cells using peptide-functionalized quantum dots and mixed delivery techniques. J. Am. Chem. Soc., 133: 10482-10489.
    CrossRef  |  Direct Link  |  
  67. Algar, W.R., K. Susumu, J.B. Delehanty and I.L. Medintz, 2011. Semiconductor quantum dots in bioanalysis: Crossing the valley of death. Anal. Chem., 83: 8826-8837.
    CrossRef  |  PubMed  |  Direct Link  |  
  68. Algar, W.R., D.E. Prasuhn, M. Stewart, T. Jennings, J.B. Blanco-Canosa, P. Dawson and I.L. Medintz, 2011. The controlled display of biomolecules on nanoparticles: A challenge suited to bioorthogonal chemistry. Bioconjugate Chem., 22: 825-858.
    CrossRef  |  Direct Link  |  
  69. Susumu, K., I.L. Medintz, J.B. Delehanty, K. Boeneman and H. Mattoussi, 2010. Modification of poly(ethylene glycol)-capped quantum dots with nickel nitrilotriacetic acid and self-assembly with histidine-tagged proteins. J. Phys. Chem. C, 114: 13526-13531.
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  70. Stewart, M.H., K. Susumu, B.C. Mei, I.L. Medintz and J.B. Delehanty et al., 2010. Multidentate poly(ethylene glycol) ligands provide colloidal stability to semiconductor and metallic nanocrystals in extreme conditions. J. Am. Chem. Soc., 132: 9804-9813.
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  71. Sapsford, K.E. J.B. Blanco-Canosa, P.E. Dawson and I.L. Medintz, 2010. Detection of HIV-1 specific monoclonal antibodies using enhancement of dye-labeled antigenic peptides. Bioconjugate Chem., 21: 393-398.
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  72. Prasuhn, D.E., J.R. Deschamps, K. Susumu, M.H. Stewart and K. Boeneman et al., 2010. Polyvalent display and packing of peptides and proteins on semiconductor quantum dots: Predicted versus experimental results. Small, 6: 555-564.
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  73. Prasuhn, D.E., J.B. Blanco-Canosa, G.J. Vora, J.B. Delehanty and K. Susumu et al., 2010. Combining chemoselective ligation with polyhistidine-driven self-assembly for the modular display of biomolecules on quantum dots. ACS Nano, 4: 267-278.
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  74. Prasuhn, D.E., A. Feltz, J.B. Blanco-Canosa, K. Susumu and M.H. Stewart et al., 2010. Quantum dot peptide biosensors for monitoring caspase 3 proteolysis and calcium ions. ACS Nano, 4: 5487-5497.
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  75. Oh, E., K. Susumu, J.B. Blanco-Canosa, I.L. Medintz, P.E. Dawson and H. Mattoussi, 2010. Preparation of stable maleimide-functionalized Au nanoparticles and their use in counting surface ligands. Small, 6: 1273-1278.
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  76. Medintz, I.L., M.H. Stewart, S.A. Trammell, K. Susumu and J.B. Delehanty et al., 2010. Quantum-dot/dopamine bioconjugates function as redox coupled assemblies for in vitro and intracellular pH sensing. Nature Mater., 9: 676-684.
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  77. Dennis, A.M., D.C. Sotto, B.C. Mei, I.L. Medintz, H. Mattoussi and G. Bao, 2010. Surface ligand effects on metal-affinity coordination to quantum dots: Implications for nanoprobe self-assembly. Bioconjugate Chem., 21: 1160-1170.
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  78. Delehanty, J.B., K. Boeneman, C.E. Bradburne, K. Robertson, J.E. Bongard and I.L. Medintz, 2010. Peptides for specific intracellular delivery and targeting of nanoparticles: Implications for developing nanoparticle-mediated drug delivery. Therapeutic Delivery, 1: 411-433.
    Direct Link  |  
  79. Delehanty, J.B., C.E. Bradburne, K. Boeneman, K. Susumu and D. Farrell et al., 2010. Delivering quantum dot-peptide bioconjugates to the cellular cytosol: Escaping from the endolysosomal system. Integrat. Biol., 2: 265-277.
    CrossRef  |  Direct Link  |  
  80. Boeneman, K., J.R. Deschamps, S. Buckhout-White, D.E. Prasuhn and J.B. Blanco-Canosa et al., 2010. Quantum dot DNA bioconjugates: attachment chemistry strongly influences the resulting composite architecture. ACS Nano, 4: 7253-7266.
    CrossRef  |  Direct Link  |  
  81. Boeneman, K., J.B. Delehanty, K. Susumu, M.H. Stewart and I.L. Medintz, 2010. Intracellular bioconjugation of targeted proteins with semiconductor quantum dots. J. Am. Chem. Soc., 132: 5975-5977.
    CrossRef  |  Direct Link  |  
  82. Boeneman, K., D.E. Prasuhn, J.B. Blanco-Canosa, P.E. Dawson and J.S. Melinger et al., 2010. Self-assembled quantum dot-sensitized multivalent DNA photonic wires. J. Am. Chem. Soc., 132: 18177-18190.
    CrossRef  |  Direct Link  |  
  83. Blanco-Canosa, J.B., I.L. Medintz, D. Farrell, H. Mattoussi and P.E. Dawson, 2010. Rapid covalent ligation of fluorescent peptides to water solubilized quantum dots. J. Am. Chem. Soc., 132: 10027-10033.
    CrossRef  |  Direct Link  |  
  84. Sapsford, K.E., D. Farrell, S. Sun, A. Rasooly, H. Mattoussi and I.L. Medintz, 2009. Monitoring of enzymatic proteolysis on a electroluminescent-CCD microchip platform using quantum dot-peptide substrates. Sensors Actuators B: Chem., 139: 13-21.
    CrossRef  |  Direct Link  |  
  85. Mei, B.C., K. Susumu, I.L. Medintz and H. Mattoussi, 2009. Polyethylene glycol-based bidentate ligands to enhance quantum dot and gold nanoparticle stability in biological media. Nature Prot., 4: 412-423.
    CrossRef  |  Direct Link  |  
  86. Medintz, I.L., T. Pons, K. Susumu, K. Boeneman and A. Dennis et al., 2009. Resonance energy transfer between luminescent quantum dots and diverse fluorescent protein acceptors. J. Phys. Chem. C, 113: 18552-18561.
    CrossRef  |  Direct Link  |  
  87. Medintz, I.L., D. Farrell, K. Susumu, S.A. Trammell and J.R. Deschamps et al., 2009. Multiplex charge-transfer interactions between quantum dots and peptide-bridged ruthenium complexes. Anal. Chem., 81: 4831-4839.
    CrossRef  |  Direct Link  |  
  88. Medintz, I.L., 2009. Interfacing biology with nanomaterials. Mater. Today, 12: 6-7.
    CrossRef  |  Direct Link  |  
  89. Medintz, I.L. and H. Mattoussi, 2009. Quantum dot-based resonance energy transfer and its growing application in biology. Phys. Chem. Chem. Phys., 11: 17-45.
    CrossRef  |  Direct Link  |  
  90. Delehanty, J.B., K. Boeneman, C.E. Bradburne, K. Robertson and I.L. Medintz, 2009. Quantum dots: A powerful tool for understanding the intricacies of nanoparticle-mediated drug delivery. Expert Opin. Drug Deliv., 6: 1091-1112.
    CrossRef  |  Direct Link  |  
  91. Delehanty, J.B., H. Mattoussi and I.L. Medintz, 2009. Delivering quantum dots into cells: Strategies, progress and remaining issues. Anal. Bioanal. Chem., 393: 1091-1105.
    CrossRef  |  Direct Link  |  
  92. Boeneman, K., B.C. Mei, A.M. Dennis, G. Bao, J.R. Deschamps, H. Mattoussi and I.L. Medintz, 2009. Sensing Caspase 3 activity with quantum dot-fluorescent protein assemblies. J. Am. Chem. Soc., 131: 3828-3829.
    CrossRef  |  Direct Link  |  
  93. Berti, L., P.S. D'Agostino, K. Boeneman and I.L. Medintz, 2009. Improved peptidyl linkers for self-assembly of semiconductor quantum dot bioconjugates. Nano Res., 2: 121-129.
    CrossRef  |  Direct Link  |  
  94. Berti, L., I.L. Medintz, A. Alessandrini and P. Facci, 2009. A one-pot functionalization strategy for immobilizing proteins onto linear dsDNA scaffolds. Nanotechnology, Vol. 20. 10.1088/0957-4484/20/23/235101.
    CrossRef  |  Direct Link  |  
  95. Yeung, S.H., I.L. Medintz, S.A. Greenspoon and R.A. Mathies, 2008. Rapid determination of monozygous twinning with a microfabricated capillary array electrophoresis genetic-analysis device. Clin. Chem., 54: 1080-1084.
    CrossRef  |  PubMed  |  
  96. Sapsford, K.E., C. Bradburne, J.B. Delehanty and I.L. Medintz, 2008. Sensors for detecting biological agents. Mater. Today, 11: 38-49.
    CrossRef  |  Direct Link  |  
  97. Mei, B.C., K. Susumu, I.L. Medintz, J.B. Delehanty, T.J. Mountziaris and H. Mattoussi, 2008. Modular poly(ethylene glycol) ligands for biocompatible semiconductor and gold nanocrystals with extended pH and ionic stability. J. Mater. Chem., 18: 4949-4958.
    CrossRef  |  Direct Link  |  
  98. Medintz, I.L., T. Pons, S.P. Trammell, A.F. Grimes and D.S. English et al., 2008. Interactions between redox complexes and semiconductor quantum dots coupled via a peptide bridge. J. Am. Chem. Soc., 130: 16745-16756.
    CrossRef  |  Direct Link  |  
  99. Medintz, I.L., T. Pons, J.B. Delehanty, K. Susumu, F.M. Brunel, P.E. Dawson and H. Mattoussi, 2008. Intracellular delivery of quantum dot-protein cargos mediated by cell penetrating peptides. Bioconjugate Chem., 19: 1785-1795.
    CrossRef  |  Direct Link  |  
  100. Medintz, I.L., H. Mattoussi and A.R. Clapp, 2008. Potential clinical applications of quantum dots. Int. J. Nanomed., 3: 151-167.
    Direct Link  |  
  101. Clapp, A.R., E.R. Goldman, H.T. Uyeda, E.L. Chang, J.L. Whitley and I.L. Medintz, 2008. Monitoring of enzymatic proteolysis using self-assembled quantum dot-protein substrate sensors. J. Sensors. 10.1155/2008/797436.
    CrossRef  |  Direct Link  |  
  102. Susumu, K., H.T. Uyeda, I.L. Medintz, T. Pons, J.B. Delehanty and H. Mattoussi, 2007. Enhancing the stability and biological functionalities of quantum dots via compact multifunctional ligands. J. Am. Chem. Soc., 129: 13987-13996.
    CrossRef  |  Direct Link  |  
  103. Susumu, K., H.T. Uyeda, I.L. Medintz and H. Mattoussi, 2007. Design of biotin-functionalized luminescent quantum dots. J. Biomed. Biotechnol. 10.1155/2007/90651.
    CrossRef  |  Direct Link  |  
  104. Sapsford, K.E., T. Pons, I.L. Medintz, S. Higashiya, F.M. Brunel, P.E. Dawson and H. Mattoussi, 2007. Kinetics of metal-affinity driven self-assembly between proteins or peptides and CdSe-ZnS quantum dots. J. Phys. Chem. C, 111: 11528-11538.
    CrossRef  |  Direct Link  |  
  105. Pons, T., I.L. Medintz, K.E. Sapsford, S. Higashiya, A.F. Grimes, D.S. English and H. Mattoussi, 2007. On the quenching of semiconductor quantum dot photoluminescence by proximal gold nanoparticles. Nano Lett., 7: 3157-3164.
    CrossRef  |  Direct Link  |  
  106. Medintz, I.L., L. Berti, T. Pons, A.F. Grimes and D.S. English et al., 2007. A reactive peptidic linker for self-assembling hybrid quantum dot-DNA bioconjugates. Nano Lett., 7: 1741-1748.
    CrossRef  |  Direct Link  |  
  107. Medintz, I.L., G.J. Vora, A.M. Rahbar and D.C. Thach, 2007. Transcript and proteomic analyses of wild-type and GPA2 mutant Saccharomyces cerevisiae strains suggest a role for glycolytic carbon source sensing in pseudohyphal differentiation. Mol. BioSyst., 3: 623-634.
    CrossRef  |  Direct Link  |  
  108. Lassman, M.E., A. Rahbar, I.L. Medintz and F. Ligler, 2007. Incorporation of 18oxygen into peptide mixtures and their analysis with multi dimensional chromatography and mass-spectroscopy. Anal. Lett., 40: 1864-1878.
  109. Emrich, C.A., I.L. Medintz, W.K. Chu and R.A. Mathies, 2007. Microfabricated two-dimensional electrophoresis device for differential protein expression profiling. Anal. Chem., 79: 7360-7366.
    CrossRef  |  Direct Link  |  
  110. Clapp, A.R., T. Pons, I.L. Medintz, J.B. Delehanty and J.S. Melinger et al., 2007. Two‐photon excitation of quantum‐dot‐based fluorescence resonance energy transfer and its applications. Adv. Mat., 19: 1921-1926.
    CrossRef  |  Direct Link  |  
  111. Sapsford, K.E., T. Pons, I.L. Medintz and H. Mattoussi, 2006. Biosensing with luminescent semiconductor quantum dots. Sensors, 6: 925-953.
    Direct Link  |  
  112. Sapsford, K.E., L. Berti and I.L. Medintz, 2006. Materials for fluorescence resonance energy transfer analysis: beyond traditional donor-acceptor combinations. Angewandte Chemie Int., 45: 4562-4589.
    CrossRef  |  Direct Link  |  
  113. Pons, T., I.L. Medintz, X. Wang, D.S. English and H. Mattoussi, 2006. Solution-phase single quantum dot fluorescence resonance energy transfer. J. Am. Chem. Soc., 128: 15324-15331.
    CrossRef  |  Direct Link  |  
  114. Pons, T., I.L. Medintz, M. Sykora and H. Mattoussi, 2006. Spectrally-resolved energy transfer using quantum dot donors: Ensemble and single-molecule studies. Phys. Rev. B. Vol. 73. .
    Direct Link  |  
  115. Pons, T., H.T. Uyeda, I.L. Medintz and H. Mattoussi, 2006. Hydrodynamic dimensions, electrophoretic mobility, and stability of hydrophilic quantum dots. J. Phys. Chem. B., 110: 20308-20316.
    CrossRef  |  Direct Link  |  
  116. Medintz, I.L., K.E. Sapsford, A.R. Clapp, T. Pons, S. Higashiya, J.T. Welch and H. Mattoussi, 2006. Designer variable repeat length polypeptides as scaffolds for surface immobilization of quantum dots. J. Phys. Chem. B., 110: 10683-10690.
    CrossRef  |  Direct Link  |  
  117. Medintz, I.L., A.R. Clapp, F.M. Brunel, T. Tiefenbrunn and H.T. Uyeda et al., 2006. Proteolytic activity monitored by fluorescence resonance energy transfer through quantum-dot�peptide conjugates. Nat. Mater., 5: 581-589.
    Direct Link  |  
  118. Medintz, I.L., 2006. Recent progress in developing FRET-based intracellular sensors for the detection of small molecule nutrients and ligands. Trends Biotechnol., 24: 539-542.
    CrossRef  |  Direct Link  |  
  119. Medintz, I.L. and J.R. Deschamps, 2006. Maltose-binding protein: A versatile platform for prototyping biosensing. Curr. Opin. Biotechnol., 17: 17-27.
    CrossRef  |  Direct Link  |  
  120. Medintz, I., 2006. Universal tools for biomolecular attachment to surfaces. Nat. Mater., 5: 842-842.
    CrossRef  |  Direct Link  |  
  121. Goldman, E.R., I.L. Medintz and H. Mattoussi, 2006. Luminescent quantum dots in immunoassays. Anal. Bioanal. Chem., 384: 560-563.
    CrossRef  |  Direct Link  |  
  122. Delehanty, J.B., I.L. Medintz, T. Pons, F.M. Brunel, P.E. Dawson and H. Mattoussi, 2006. Self-assembled quantum dot-peptide bioconjugates for selective intracellular delivery. Bioconjugate Chem., 17: 920-927.
    CrossRef  |  Direct Link  |  
  123. Clapp, A.R., I.L. Medintz and H. Mattoussi, 2006. Forster resonance energy transfer investigations using quantum‐dot fluorophores. Chem. Phys. Chem., 7: 47-57.
    CrossRef  |  Direct Link  |  
  124. Anderson, G.P., S.C. Moreira, P.T. Charles, I.L. Medintz, E.R. Goldman, M. Zeinali and C.R. Taitt, 2006. TNT detection using multiplexed liquid array displacement immunoassays. Anal. Chem., 78: 2279-2285.
    CrossRef  |  Direct Link  |  
  125. Uyeda, H.T., I.L., J.K. Jaiswal, S.M. Simon and H. Mattoussi, 2005. Synthesis of compact multidentate ligands to prepare stable hydrophilic quantum dot fluorophores. J. Am. Chem. Soc., 127: 3870-3878.
    Direct Link  |  
  126. Medintz, I.L., K.E. Sapsford, J.H. Konnert, A. Chatterji, T. Lin, J.E. Johnson and H. Mattoussi, 2005. Decoration of discretely immobilized cowpea mosaic virus with luminescent quantum dots. Langmuir, 21: 5501-5510.
    Direct Link  |  
  127. Medintz, I.L., H.T. Uyeda, E.R. Goldman and H. Mattoussi, 2005. Quantum dot bioconjugates for imaging, labelling and sensing. Nat. Mater., 4: 435-446.
    Direct Link  |  
  128. Medintz, I.L., E.R. Goldman, M.E. Lassman, A. Hayhurst, A.W. Kusterbeck and J.R. Deschamps, 2005. Self-assembled TNT biosensor based on modular multifunctional surface-tethered components. Anal. Chem., 77: 365-372.
    Direct Link  |  
  129. Medintz, I.L., A.R. Clapp, J.S. Melinger, J.R. Deschamps and H. Mattoussi, 2005. A reagentless biosensing assembly based on quantum dot-donor Forster resonance energy transfer. Advan. Mater., 17: 2450-2455.
    CrossRef  |  Direct Link  |  
  130. Goldman, E.R., I.L. Medintz, J.L. Whitley, A. Hayhurst and A.R. Clapp et al., 2005. A hybrid quantum dot-antibody fragment fluorescence resonance energy transfer-based TNT sensor. J. Am. Chem. Soc., 127: 6744-6751.
    Direct Link  |  
  131. Goldman, E.R., I.L. Medintz, A. Hayhurst, G.P. Anderson and J.M. Mauro et al., 2005. Self-assembled luminescent CdSe-ZnS quantum dot bioconjugates prepared using engineered poly-histidine terminated proteins. Analytica Chimica Acta, 534: 63-67.
    CrossRef  |  
  132. Goldman, E.R., A.L. Egge, I.L. Medintz, M.E. Lassman and G.P. Anderson, 2005. Application of a homogenous assay for the detection of 2, 4, 6-trinitrotoluene to environmental water samples. Scientific World J., 5: 446-451.
    CrossRef  |  Direct Link  |  
  133. Clapp, A.R., I.L. Medintz, H.T. Uyeda, B.R. Fisher, E.R. Goldman, M.G. Bawendi and H. Mattoussi, 2005. Quantum dot-based multiplexed fluorescence resonance energy transfer. J. Am. Chem. Soc., 127: 18212-18221.
    CrossRef  |  Direct Link  |  
  134. Clapp, A.R. I.L. Medintz, B.R. Fisher, G.P. Anderson and H. Mattoussi, 2005. Can luminescent quantum dots be efficient energy acceptors with organic dye donors? J. Am. Chem Soc., 127: 1242-1250.
    Direct Link  |  
  135. Sapsford, K.E., L. Berti and I.L. Medintz, 2004. Fluorescence resonance energy transfer-concepts, applications and advances. Minerva Biotecnologica, 16: 247-273.
  136. Sapsford, K.E., I.L. Medintz, J.P. Golden, J.R. Deschamps, H.T. Uyeda and H. Mattoussi, 2004. Surface-immobilized self-assembled protein-based quantum dot nanoassemblies. Langmuir, 20: 7720-7720.
    CrossRef  |  Direct Link  |  
  137. Medintz, I.L., S.A. Trammell, H. Mattoussi and J.M. Mauro, 2004. Reversible modulation of quantum dot photoluminescence using a protein-bound photochromic fluorescence resonance energy transfer acceptor. J. Am. Chem. Soc., 126: 30-31.
    Direct Link  |  
  138. Medintz, I.L., G.P. Anderson, M.E. Lassman, E.R. Goldman, L.A. Bettencourt and J.M. Mauro, 2004. General strategy for biosensor design and construction employing multifunctional surface-tethered components. Anal. Chem., 76: 5620-5629.
    CrossRef  |  Direct Link  |  
  139. Medintz, I.L. and J.M. Mauro, 2004. Use of a cyanine dye as reporter in reagentless maltose sensors based on E. coli maltose binding protein. Analyt. Lett., 37: 209-220.
  140. Mattoussi, H., I.L. Medintz, A.R. Clapp, E.R. Goldman, J.K. Jaiswal, S.M. Simon and J.M. Mauro, 2004. Luminescent quantum dot-bioconjugates in immunoassays, FRET, biosensing, and imaging applications. J. Assoc. Lab. Autom., 9: 28-32.
    CrossRef  |  Direct Link  |  
  141. Goldman, E.R., A.R. Clapp, G.P. Anderson, H.T. Uyeda, J.M. Mauro, I.L. Medintz and H. Mattoussi,q 2004. Multiplexed toxin analysis using four colors of quantum dot fluororeagents. Anal. Chem., 76: 684-688.
    Direct Link  |  
  142. Clapp, A.R., I.L. Medintz, J.M. Mauro, B.R. Fisher, M.G. Bawendi and H. Mattoussi, 2004. Fluorescence resonance energy transfer between quantum dot donors and dye-labeled protein acceptors. J. Am. Chem. Soc., 126: 301-310.
    CrossRef  |  Direct Link  |  
  143. Medintz, I.L., E.R. Goldman, M.E. Lassman and J.M. Mauro, 2003. A fluorescence resonance energy transfer sensor based on maltose binding protein. Bioconjugate Chem., 14: 909-918.
    Direct Link  |  
  144. Medintz, I.L., A.R. Clapp, H. Mattoussi, E.R. Goldman, B. Fisher and J.M. Mauro, 2003. Self-assembled nanoscale biosensors based on quantum dot FRET donors. Nat. Mater., 2: 630-638.
    Direct Link  |  
  145. Wang, X., M. Bali, I. Medintz and C.A. Michels, 2002. Intracellular maltose is sufficient to induce MAL gene expression in Saccharomyces cerevisiae. Eukaryotic Cell, 1: 696-703.
    Direct Link  |  
  146. Medintz, I.L., L. Berti and R.A. Mathies, 2002. BioFeedback: Novel energy transfer fluorescence labeling cassette. BioTechn., 32: 270-272.
  147. Medintz, I., C. Kingston, H. Duran, L. Barry, L. Levine and L. Kobilinsky, 2002. Characterization of 2 New York City Jewish Populations at 6 short tandem repeat loci. Human Biol., 74: 143-151.
    Direct Link  |  
  148. Emrich, C.A., H. Tian, I.L. Medintz and R.A. Mathies, 2002. Microfabricated 384-lane capillary array electrophoresis bioanalyzer for ultrahigh-throughput genetic analysis. Analy. Chem., 74: 5076-5083.
    Direct Link  |  
  149. Scherer, J.R., B.M. Paegel, G. Wedemayer, C.A. Emrich, J. Lo, I. Medintz and R.A. Mathies, 2001. Pressure loader for microchannel plate capillary array electrophoresis. BioTechniques, 31: 1150-1556.
    Direct Link  |  
  150. Medintz, I.L., L. Berti, C.A. Emrich, J. Tom, J.R. Scherer and R.A. Mathies, 2001. Genotyping energy-transfer-cassette-labeled short-tandem-repeat amplicons with capillary array electrophoresis michrochannel plates. Clin. Chem., 47: 1614-1621.
    Direct Link  |  
  151. Medintz, I.L., B.M. Paegel, R.G. Blazej, C.A. Emrich, L. Berti, J.R. Scherer and R.A. Mathies, 2001. High-performance genetic analysis using microfabricated capillary array electrophoresis microplates. Electrophoresis, 22: 3845-3856.
    Direct Link  |  
  152. Medintz, I.L., B.M. Paegel and R.A. Mathies, 2001. Microfabricated capillary array electrophoresis DNA analysis systems. J. Chromatogr. A., 924: 265-270.
    CrossRef  |  Direct Link  |  
  153. Medintz, I., W.W. Wong, L. Berti, L. Shiow, J. Tom, J. Scherer, G. Sensabaugh and R.A. Mathies, 2001. High performance multiplex SNP analysis of 3 haemochromatosis related mutations with capillary array electrophoresis microplates. Genome Res., 11: 413-421.
    Direct Link  |  
  154. Medintz, I., W.W. Wong and R.A. Mathies, 2001. Fluorescence labeling methods for microchannel plate capillary electrophoresis DNA sizing. J. Capillary Electrophor. Micro. Technol., 7: 43-49.
    Direct Link  |  
  155. Legally, E.T., I. Medintz and R.A. Mathies, 2001. Single molecule DNA amplification and analysis in an integrated microfluidic device. Anal. Chem., 73: 565-570.
    Direct Link  |  
  156. Berti, L., J. Xie, I. Medintz, A.N. Glazer and R.A. Mathies, 2001. Energy transfer cassettes for facile labeling of sequencing and PCR primers. Anal. Biochem., 292: 188-197.
    CrossRef  |  Direct Link  |  
  157. Berti, L., I. Medintz, J. Tom and R.A. Mathies, 2001. Energy transfer cassette labeling for capillary array electrophoresis short tandem repeat DNA fragment sizing. Bioconjugate Chem., 12: 493-500.
    Direct Link  |