Dr. Ahmed  Abdelbaset Ahmed Attia Ismail
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Dr. Ahmed Abdelbaset Ahmed Attia Ismail

Post-doctoral Fellow
University of Louisville, USA


Highest Degree
Ph.D. in Veterinary Medical Science from Zagazig University, Zagazig, Egypt

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Biography

Dr. Abdelbaset-Ismail was born and grew up in Province of El-Sharkia, Egypt. In 2000, Dr. Abdelbaset-Ismail received Bachelor’s degree (BVMSc) in Veterinary Medical Science at Faculty of Veterinary Medicine Zagazig University. Dr. Abdelbaset-Ismail was consequently employed as a Teaching Assistant at the Department of Animal Surgery, Radiology, and Anesthesiology. As recognition of his outstanding records and capabilities, he was employed as an Assistant Lecturer at the same Department, after obtaining his Master’s degree (MVSc). During the era (2008-2011) at University of Veterinary Medicine Hannover, he gained much experience in experimental surgery, CT imaging and regenerative medicine using adipose derived-MSCs. After he received the PhD, he was appointed as a Lecturer at Department of Animal Surgery. Later on, Dr. Abdelbaset-Ismail then has joined the Stem Cell Institute at James Graham Brown Cancer, University of Louisville, as a Visiting Scholar from September 2013 to March 2014, where he has been then employed as a Postdoctoral Associate beginning May 2014. Dr. Abdelbaset-Ismail is one of the founding members of International Perinatal Stem Cells Society, and he has received the very prestigious 2015 Abstract Achievement Award from the American Society of Hematology. Dr. Abdelbaset-Ismail has developed remarkable technical skills in cell transplantation for various animal models, molecular characterization, propagating cells in vitro and in vivo. He has also gained salient experience in various experimental setups using hematopoietic stem cells, bone marrow, cord blood-derived and adipose tissue-derived MSCs, very small embryonic-like stem cells, leukemic cells, and germline-derived cells. He has also much experience in context of homing, mobilization, and engraftment of hematopoietic stem cells and cancer research.

Area of Interest:

Biomedical Sciences
100%
Stem Cells
62%
Regenerative Medicine
90%
Leukemia
75%
Veterinary Medicine
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
0
Abstracts
0

Selected Publications

  1. Aref, M., A. Abdelbaset-Ismail, H. Emam, K. Dhama, 2019. Identification of normal horse head structures, with special reference to paranasal sinuses, by anatomical cross-section and magnetic resonance imaging (MRI). Adv. Anim. Vet. Sci., 7: 200-204.
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  2. Abdelbaset-Ismail, A., M. Cymer, S. Borkowska-Rzeszotek, K. Brzeźniakiewicz-Janus, P. Rameshwar, S.S. Kakar and M.Z. Ratajczak, 2019. Bioactive phospholipids enhance migration and adhesion of human leukemic cells by inhibiting Heme oxygenase 1 (HO-1) and inducible nitric oxygenase synthase (iNOS) in a p38 MAPK-dependent manner. Stem Cell Rev. Rep., 15: 139-154.
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  3. Gugjoo, M.B., A. Abdelbaset-Ismail, H.P. Aithal, P. Kinjavdekar, A.M. Pawde, G.S. Kumar and G.T. Sharma, 2017. Mesenchymal stem cells with IGF-1 and TGF-β1 in laminin gel for osteochondral defects in rabbits. Biomed. Pharm., 93: 1165-1174.
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  4. Adamiak, M., A. Abdelbaset-Ismail, M. Suszynska, A. Abdel-Latif, J. Ratajczak and M.Z. Ratajczak, 2017. Novel evidence that the mannan-binding lectin pathway of complement activation plays a pivotal role in triggering mobilization of hematopoietic stem/progenitor cells by activation of both the complement and coagulation cascades. Leukemia 31: 262-265.
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  5. Adamiak, M., A. Abdelbaset-Ismail, J.B. Moore, J. Zhao, A. Abdel-Latif, M. Wysoczynski and M.Z. Ratajczak, 2017. Inducible nitric oxide synthase (iNOS) is a novel negative regulator of hematopoietic stem/progenitor cell trafficking. Stem Cell Rev. Rep., 13: 92-103.
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  6. Abdelbaset-Ismail, A., S. Borkowska-Rzeszotek, E. Kubis, K. Bujko, K. Brzeźniakiewicz-Janus, L. Bolkun and M.Z. Ratajczak, 2017. Activation of the complement cascade enhances motility of leukemic cells by downregulating expression of HO-1. Leukemia, 31: 446-458.
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  7. Abdelbaset Ismail, A., D. Pedziwiatr, G. Schneider, J. Niklinski, R. Charkiewicz, M. Moniuszko and M.Z. Ratajczak, 2017. Pituitary sex hormones enhance the pro metastatic potential of human lung cancer cells by downregulating the intracellular expression of heme oxygenase 1. Int. J. Oncol., 50: 317-328.
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  8. Abdelaal, A., A. Abdelbaset-Ismail, M. Gomaa, S. Gouda and K. Dhama, 2017. Efficacy of Ultrasound in Diagnosis and Management of Internal Abscessations in Egyptian Buffaloes (Bubalus Bubalis). Asian J. Ani. Veterinary Adv., 12: 239-246.
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  9. Poniewierska-Baran, A., G.A.B.R.I.E.L.A. Schneider, W. Sun, A. Abdelbaset-Ismail, F.G. Barr and M.Z. Ratajczak, 2016. Human rhabdomyosarcoma cells express functional pituitary and gonadal sex hormone receptors: Therapeutic implications. Int. J. Oncol., 48: 1815-1824.
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  10. Adamiak, M., J.B. Moore Iv, J. Zhao, A. Abdelbaset-Ismail, K. Grubczak, S. Rzeszotek and M.Z. Ratajczak, 2016. Downregulation of heme oxygenase 1 (HO-1) activity in hematopoietic cells enhances their engraftment after transplantation. Cell Transplant., 25: 1265-1276.
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  11. Adamiak, M., A. Poniewierska-Baran, S. Borkowska, G. Schneider, A. Abdelbaset-Ismail, M. Suszynska and M.Z. Ratajczak, 2016. Evidence that a lipolytic enzyme-hematopoietic-specific phospholipase C-β2—promotes mobilization of hematopoietic stem cells by decreasing their lipid raft-mediated bone marrow retention and increasing the promobilizing effects of granulocytes. Leukemia, 30: 919-928.
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  12. Adamiak, M., A. Abdelbaset-Ismail, M. Kucia, J. Ratajczak and M.Z. Ratajczak, 2016. Toll-like receptor signaling-deficient mice are easy mobilizers: evidence that TLR signaling prevents mobilization of hematopoietic stem/progenitor cells in HO-1-dependent manner. Leukemia, 30: 2416-2419.
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  13. Adamiak, M., M. Suszynska, A. Abdel-Latif, A. Abdelbaset-Ismail, J. Ratajczak and M.Z. Ratajczak, 2016. The Involvment of Hematopoietic-Specific PLC -β2 in Homing and Engraftment of Hematopoietic Stem/Progenitor Cells. Stem Cell Rev. Rep., 12: 613-620.
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  14. Abdelbaset-Ismail, A., M. Suszynska, S. Borkowska, M. Adamiak, J. Ratajczak, M. Kucia and M.Z. Ratajczak, 2016. Human haematopoietic stem/progenitor cells express several functional sex hormone receptors. J. Cell. Mol. Med., 20: 134-146.
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  15. Abdelbaset-Ismail, A., D. Pedziwiatr, E. Suszyńska, S. Sluczanowska-Glabowska, G. Schneider, S.S. Kakar and M.Z. Ratajczak, 2016. Vitamin D3 stimulates embryonic stem cells but inhibits migration and growth of ovarian cancer and teratocarcinoma cell lines. J. Ovarian Res., Vol. 9. 10.1186/s13048-016-0235-x.
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  16. Abdelbaset-Ismail, A., B.G. Mudasir, G. Alaa, G. Mohamed and D. Kuldeep et al., 2016. Radiographic specification of skeletal maturation in donkeys: Defining the ossification time of donkey growth plates for preventing irreparable damage. Asian J. Anim. Vet. Adv., 11: 204-209.
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  17. Schneider, G., T. Glaser, A.A. Ismail, H. Ulrich and M.Z. Ratajczak, 2015. Extracellular nucleotides and purinergic signaling as novel, underappreciated, pro-metastatic factors for human lung cancer cells. Cancer Res., 75: 4144-4144.
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  18. Poniewierska-Baran, A., M. Suszynska, W. Sun, A. Abdelbaset-Ismail, G. Schneider, F.G. Barr and M.Z. Ratajczak, 2015. Human rhabdomyosarcoma cells express functional erythropoietin receptor: Potential therapeutic implications. Int. J. Oncol., 47: 1989-1997.
    CrossRef  |  PubMed  |  Direct Link  |  
  19. Ismail, A.A., 2015. Concise review: appreciated signaling role of high mobility group: A proteins for regulation of proliferation, pluripotency and self-re-newal of adult stem cells. Adv. Anim. Vet. Sci., 3: 276-282.
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  20. Gunjal, P.M., G. Schneider, A.A. Ismail, S.S. Kakar, M. Kucia and M.Z. Ratajczak, 2015. Evidence for induction of a tumor metastasis-receptive microenvironment for ovarian cancer cells in bone marrow and other organs as an unwanted and underestimated side effect of chemotherapy/radiotherapy. J. Ovarian Res., Vol. 8. 10.1186/s13048-015-0141-7.
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  21. Adamiak, M., J.B. Iv, J. Zhao, A. Abdelbaset-Ismail and K. Grubczak et al., 2015. Downregulation of heme oxygenase 1 (HO-1) activity in hematopoietic cells enhances their engraftment after transplantation. Cell Transplantation, 10.3727/096368915X689712.
    CrossRef  |  PubMed  |  Direct Link  |  
  22. Adamiak, M., A. Poniewierska-Baran, S. Borkowska, G. Schneider and A. Abdelbaset-Ismail et al., 2015. Evidence that a lipolytic enzyme-hematopoietic-specific phospholipase C-β2-promotes mobilization of hematopoietic stem cells by decreasing their lipid raft-mediated bone marrow retention and increasing the promobilizing effects of granulocytes. Leukemia, 10.1038/leu.2015.315.
    CrossRef  |  PubMed  |  Direct Link  |  
  23. Abdelbaset-Ismail, A., S. Borkowska, A. Janowska-Wieczorek, T. Tonn and C. Rodriguez et al., 2015. Novel evidence that pituitary gonadotropins directly stimulate human leukemic cells-studies of myeloid cell lines and primary patient AML and CML cells. Oncotarget., 10.18632/oncotarget.6698.
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  24. Samy, M.T., I.A. Shaban, I.F. Mandoh and A.A.I. El-Azzazy, 2014. Novel practical insight into application of platelet-rich plasma in combination with biore-sorbable silicate 45S5 bioactive glass for bone defect repair: An experimental study in a rabbit model. Adv. Anim. Vet. Sci., 2: 424-432.
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  25. Gunjal, P., D. Pedziwiatr, A.A. Ismail, S.S. Kakar and M.Z. Ratajczak, 2014. An emerging question about putative cancer stem cells in established cell lines: Are they true stem cells or a fluctuating cell phenotype? J. Cancer Stem Cell Res., Vol. 3. 10.14343/JCSCR.2015.3e1004.
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  26. Gomaa, M., A.I. El-Azzazy, F. El-Seddawy, M. Abdel-Maboud, A. Behery and A.B.A. El-Aal, 2014. Investigating the relationship between claw disorders and milk yield before and after claw trimming using modified dutch method in three Egyptian dairy farms. J. Anim. Health Prod., 2: 40-45.
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  27. Borkowska, S., M. Suszynska, K. Mierzejewska, A. Ismail and M. Budkowska et al., 2014. Novel evidence that crosstalk between the complement, coagulation and fibrinolysis proteolytic cascades is involved in mobilization of hematopoietic stem/progenitor cells (HSPCs). Leukemia, 28: 2148-2154.
    CrossRef  |  PubMed  |  Direct Link  |  
  28. Abdelaal, A., S. Gouda, A. Ismail and M. Gomaa, 2014. Reticular diaphragmatic hernia in Egyptian buffaloes: Clinical, hemato-biochemical and ultrasonographic findings. Pak. Vet. J., 34: 541-544.
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  29. Samy, M.T., I.A. Shaban, A.A. Ismail and I.F. Mandoh, 2013. The effect of bioactive glass and platelet-rich plasma on bone healing. Egypt. J. Basic Appl. Physiol., .
  30. Ismail, A.A., S. Wagner, H.M. Escobar, S. Willenbrock and K.A. Sterenczak et al., 2012. Effects of high-mobility group a protein application on canine adipose-derived mesenchymal stem cells in vitro. Vet. Med. Int., Vol. 2012. 10.1155/2012/752083.
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  31. Ahmed, A.I., H.M. Escobar, K. Langner, A. Schwenke and S. Willenbrock et al., 2012. Evaluation of pluripotency of canine adipose derived mesenchymal stem cells and their extension properties on poly lactic-co-gycolic acid scaffold. Egypt. J. Basic Appl. Physiol., 11: 17-29.
  32. Samy, M.T., A.E. Behery, I.A. Shabaan, A.M.A. El Aal and A.A. Ahmed, 2007. Determination of epiphyseal lines closure time of stifle joint in donkeys. Vet. Med. J. Giza, 55: 57-65.
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  33. Behery, A.E., M.T. Samy, I.A.A. Shaaban, A.M. Abd El Aal, A.A. Ahmed and J. Al-Qahirah, 2007. Determination of epiphyseal line closure time of the hock joint in donkeys. Vet. Med. J. Giza, 55: 45-56.
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