Dr. Alaaeldin Ahmed Hamza
ProfessorDepartment of Hormone Evaluation, National Organization for Drug Control and Research (NODCAR), Egypt
Highest Degree
Ph.D. in Animal Physiology from Cairo University, Egypt
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Department of Hormone Evaluation, National Organization for Drug Control and Research (NODCAR), Egypt
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Biography
Dr. Alaaeldin Ahmed Hamza, earned his PhD from Cairo University in Animal Physiology, is currently working as professor of Physiology in the National Organization for Drug Control and Research (NODCAR) Egypt. He is established scientist in the areas of liver toxicity, reproductive toxicity and liver cancer. For his highly cited publications he has ranked as the top scientists in United Arab Emirates institutions according to GSC public profiles 2017 and among the top 2% of researchers in the world by Stanford University in 2020. He has published more than 40 papers in different fields of pharmacology in many prestigious journal such as Hepatology, Scientific Report, Toxicology Letters, Toxicology, Food and Chemical Toxicology, Andrologia, Life Sciences and Molecules. His current Scopus H-index is 24 and his total citations are 2520. He is serving as a reviewer in Elsevier, Taylor, Springer and Wiley journals. He has been serving as an editorial board member of more than five international medical journals. He has participated in various national and international conferences. He has awarded the Best Individual Non Funded Research Project Award, the 9th Annual Research Conference, U.A.E. University, Al-Ain. April 21-23, 2008. ). He is member in National Committee for Biological Science. Egyptian Academy of Scientific Research and Technology. 22-10-2018-until now. He recognized as one of the best reviewers in Elsevier (2011& 2017). He is member in National Committee for Biological Science. Egyptian Academy of Scientific Research and Technology. 22-10-2018-until now. He recognized as one of the best reviewers in Elsevier (2011& 2017). His research focus areas are the development of animal models to study the protective effects of natural substances and antioxidant and oxidative stress induced by pharmacological agents such as anticancer drugs and pharmacological agents. For last 7 years, He was involved in developing in in vivo and enzyme assays in the field of cancer and oxidative stress researches. His experience has involved drug discovery, mechanism-of-action studies, biomarker development, cancer pharmacology in xenograft and chemical tumor models, pharmacology of stress response signaling. This has required a broad understanding of cancer biology and pharmacology.
Area of Interest:
Pharmacology and Toxicology
100%
Natural Products
62%
Drug Evaluation
90%
Cancer Pharmacology
75%
Toxicological Research
55%
Research Publications in Numbers
Books
0
0
Chapters
0
0
Articles
50
50
Abstracts
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Selected Publications
- Hamza, A.A., M. Gamel, A. Abdalla, Y. Abdalla and A. Amin, 2023. Gentiana lutea attenuates hepatotoxicity induced by ketoconazole in rats by fortifying the cellular antioxidant defense system. J. Basic Appl. Zool., Vol. 84. 10.1186/s41936-022-00321-7.
CrossRef | Direct Link | - Hamza, A.A., M.A. Khasawneh, H.M. Elwy, S.O. Hassanin, S.F. Elhabal and N.M. Fawzi, 2022. Salvadora persica attenuates DMBA-induced mammary cancer through downregulation oxidative stress, estrogen receptor expression and proliferation and augmenting apoptosis. Biomed. Pharmacother., Vol. 147. 10.1016/j.biopha.2022.112666.
CrossRef | Direct Link | - ELhabal, S.F., H.M. Elwy, S. Hassanin, A.A. El-Rashedy, A.A. Hamza and M.A. Khasawneh, 2022. Biosynthesis and characterization of gold and copper nanoparticles from Salvadora persica fruit extracts and their biological properties. Int. J. Nanomed., 17: 6095-6112.
CrossRef | Direct Link | - Hamza, A.A., S.O. Hassanin, S. Hamza, A. Abdalla and A. Amin, 2021. Polyphenolic-enriched olive leaf extract attenuated doxorubicin-induced cardiotoxicity in rats via suppression of oxidative stress and inflammation. J. Basic Appl. Zool., Vol. 82. 10.1186/s41936-021-00251-w.
CrossRef | Direct Link | - Hamza, A.A., G.H. Heeba, S. Hamza, A. Abdalla and A. Amin, 2021. Standardized extract of ginger ameliorates liver cancer by reducing proliferation and inducing apoptosis through inhibition oxidative stress/ inflammation pathway. Biomed. Pharmacother., 10.1016/j.biopha.2020.111102.
CrossRef | Direct Link | - Abdalla, Y., A. Abdalla, A.A. Hamza and A. Amin, 2021. Safranal prevents liver cancer through inhibiting oxidative stress and alleviating inflammation. Front. Pharmacol., Vol. 12. 10.3389/fphar.2021.777500.
CrossRef | Direct Link | - Youssef F.S., M.L. Ashour, H.A. El‐Beshbishy, A.A. Hamza, A.N.B. Singab and M. Wink, 2020. Pinoresinol‐4‐O‐β‐D‐glucopyranoside: a lignan from prunes (Prunus domestica) attenuates oxidative stress, hyperglycaemia and hepatic toxicity in vitro and in vivo. Journal of Pharmacy and Pharmacology https://doi.org/10.1111/jphp.13358 http://dx.doi.org/10.1111/jphp.13358.
CrossRef | - Hamza, A.A., M.G. Mohamed, F.M. Lashin and A. Amin, 2020. Dandelion prevents liver fibrosis, inflammatory response, and oxidative stress in rats. J. Basic Appl. Zool., Vol. 81. 10.1186/s41936-020-00177-9.
CrossRef | Direct Link | - Hamza, A.A., F.M. Lashin, M. Gamel, S.O. Hassanin, Y. Abdalla and A. Amin, 2020. Hawthorn herbal preparation from crataegus oxyacantha attenuates in vivo carbon tetrachloride -induced hepatic fibrosis via modulating oxidative stress and inflammation. Antioxidants, 10.3390/antiox9121173.
CrossRef | Direct Link | - EL-Dakhly, S.M., A.A.A. Salama, S.O.M. Hassanin, N.N. Yassen, A.A. Hamza and A. Amin, 2020. Aescin and diosmin each alone or in low dose-combination ameliorate liver damage induced by carbon tetrachloride in rats. BMC Res. Notes, Vol. 13. 10.1186/s13104-020-05094-2.
CrossRef | Direct Link | - Hamza, A.A., G.H. Heeba, H.M. Elwy, C. Murali, R. El-Awady and A. Amin, 2018. Molecular characterization of the grape seeds extract’s effect against chemically induced liver cancer: In vivo and in vitro analyses. Sci. Rep., Vol. 8. 10.1038/s41598-018-19492-x.
CrossRef | Direct Link | - Hamza, A.A., E.M. Fikry, W. Abdallah and A. Amin, 2018. Mechanistic insights into the augmented effect of bone marrow mesenchymal stem cells and thiazolidinediones in streptozotocin-nicotinamide induced diabetic rats. Sci. Rep., Vol. 8. 10.1038/s41598-018-28029-1.
CrossRef | Direct Link | - Hamza, A.A., 2018. Comments to the editor concerning the paper entitled “Mitochondrial dysfunction in diabetic cardiomyopathy: Effect of mesenchymal stem cell with PPAR-γ agonist or exendin-4” Mohamed Abd Elaziz Wassef et al. Exp. Clin. Endocrinol. Diabetes, 126: 465-466.
CrossRef | Direct Link | - Heeba, G.H., A.A. Hamza and S.O. Hassanin, 2016. Induction of heme oxygenase-1 with hemin alleviates cisplatin-induced reproductive toxicity in male rats and enhances its cytotoxicity in prostate cancer cell line. Toxicol. Lett., 15: 38-50.
CrossRef | PubMed | Direct Link | - Hamza, A.A., T.S. Ksiksi, O.A.A. Shamsi and S.A. Balfaqh, 2016. α-glucosidase inhibitory activity of common traditional medicinal plants used for diabetes mellitus. J. Dev. Drugs, Vol. 4. 10.4172/2329-6631.1000144.
CrossRef | Direct Link | - Hamza, A.A., S.M. Ahmed, H.M. Elwy and O.K. Radwan, 2016. Radwan Salvia fruticosa-mediated antioxidant protection against oxidative stress in streptozotocin - induced diabetic rats. Int. J. Pharm. Biol. Sci., 6: 138-149.
- Hamza, A.A., M.M. Ahmed, H.M. Elwey and A. Amin, 2016. Melissa officinalis protects against doxorubicin-induced cardiotoxicity in rats and potentiates its anticancer activity on MCF-7 cells. PloS One, Vol. 11. 10.1371/journal.pone.0167049.
CrossRef | - Hamza, A.A., H.M. Elwy and A.M. Badawi, 2016. Fenugreek seed extract attenuates cisplatin‐induced testicular damage in wistar rats. Andrologia, 48: 211-221.
CrossRef | PubMed | Direct Link | - Hamza, A.A., F. El Hodairy and A.M. Badawi, 2016. Safranal ameliorates sodium valproate-induced liver toxicity in rats by targeting gene expression, oxidative stress and apoptosis. J. Biomed. Pharm. Res., 4: 46-60.
Direct Link | - Amin, A., A.A. Hamza, S. Daoud, K. Khazanehdari and A. Al Hrout et al., 2016. Saffron-based crocin prevents early lesions of liver cancer: In vivo, in vitro and network analyses. Recent Pat. Anti-Cancer Drug Discovery, 11: 121-133.
Direct Link | - Khasawneh, M.A., A. Koch, H.M. Elwy, A.A. Hamza and R. Schneider-Stock, 2015. Leptadenia pyrotechnica induces P53-dependent apoptosis in colon cancer cells. Nat. Prod. Chem. Res., Vol. 3. 10.4172/2329-6836.1000177.
CrossRef | Direct Link | - Heeba, G.H. and A.A. Hamza, 2015. Rosuvastatin ameliorates diabetes-induced reproductive damage via suppression of oxidative stress, inflammatory and apoptotic pathways in male rats. Life Sci., 141: 13-19.
CrossRef | PubMed | Direct Link | - Saied, N.M. and A.A. Hamza, 2014. Selenium ameliorates isotretinoin-induced liver injury and dyslipidemia via antioxidant effect in rats. Toxicol. Mech. Methods, 24: 433-437.
CrossRef | PubMed | Direct Link | - Khasawneh, M., H.M. Elwy, N.M. Fawzi, A.A. Hamza, A.R. Chevidenkandy and A.H. Hassan, 2014. Antioxidant activity and lipoxygenase inhibitory effect of Caralluma arabica and related polyphenolic constituents. Am. J. Plant Sci., 5: 1623-1631.
CrossRef | Direct Link | - Ksiksi, T. and A.A. Hamza, 2012. Antioxidant, lipoxygenase and histone deacetylase inhibitory activities of Acridocarbus orientalis from Al Ain and Oman. Mol., 17: 12521-12532.
CrossRef | PubMed | Direct Link | - Choi, Y.K., B.K. Poudel, N. Marasini, K.Y. Yang and J.W. Kim et al., 2012. Enhanced solubility and oral bioavailability of itraconazole by combining membrane emulsification and spray drying technique. Int. J. Pharm., 434: 264-271.
CrossRef | Direct Link | - Amin, A., C. Abraham, A.A. Hamza, Z.A. Abdalla, S.B. Al-Shamsi, S.S. Harethi and S. Daoud, 2012. A standardized extract of Ginkgo biloba neutralizes cisplatin-mediated reproductive toxicity in rats. BioMed. Res. Int., Vol. 2012. 10.1155/2012/362049.
CrossRef | Direct Link | - Khasawneh, M.A., H.M. Elwy, N.M. Fawzi, A.A. Hamza, A.R. Chevidenkandy and A.H. Hassan, 2011. Antioxidant activity, lipoxygenase inhibitory effect and polyphenolic compounds from Calotropis procera (Ait.) R. Br. Res. J. Phytochem., 5: 80-88.
CrossRef | Direct Link | - Khasawneh, M.A., H.M. Elwy, A.A. Hamza, N.M. Fawzi and A.H. Hassan, 2011. Antioxidant, anti-lipoxygenase and cytotoxic activity of Leptadenia pyrotechnica (Forssk.) decne polyphenolic constituents. Mol., 16: 7510-7521.
CrossRef | PubMed | Direct Link | - Kataya, H.H., A.A. Hamza, G.A. Ramadan and M.A. Khasawneh, 2011. Effect of licorice extract on the complications of diabetes nephropathy in rats. Drug Chem. Toxicol., 34: 101-108.
CrossRef | PubMed | Direct Link | - Gaafa, K.M., M.M. Badawy and A.A. Hamza, 2011. The protective effects of ascorbic acid, cimetidine and nifidipine on diethyldithiocarbamate-induced hepatic toxicity in albino rats. Drug Chem. Toxicol., 34: 405-419.
CrossRef | PubMed | Direct Link | - Amin, A., A. Hamza, K. Bajbouj, S.A. Ashraf and S. Daoud, 2011. Saffron: A potential candidate for a novel anti-cancer drug against hepatocellular carcinoma. Hepatology, 54: 857-867.
CrossRef | - Hamza, A.A., 2010. Ameliorative effects of Moringa oleifera Lam seed extract on liver fibrosis in rats. Food Chem. Toxicol., 48: 345-355.
CrossRef | PubMed | Direct Link | - Hamza, A.A., G.A. Ramadan and M.A. Khasawneh, 2009. Licorice extract ameliorates diabetic nephropathy in rats. Planta Med., Vol. 75. 10.1055/s-0029-1234734.
CrossRef | Direct Link | - Amin, A., A.A. Hamza, A. Kambal and S. Daoud, 2008. Herbal extracts counteract cisplatin-mediated cell death in rat testis. Asian J. Androl., 10: 291-297.
CrossRef | PubMed | Direct Link | - Kataya, H. and A. Hamza, 2007. Protective effect of red cabbge (Brassica oleracea) on oxidative stress and experimental diabetic nephropathy in rats. eCAM, 4: 1-7.
- Hassan, H.A., A.H. Al-Marzouqi, B. Jobe, A.A. Hamza and G.A. Ramadan, 2007. Enhancement of dissolution amount and in vivo bioavailability of itraconazole by complexation with β-cyclodextrin using supercritical carbon dioxide. J. Pharm. Biomed. Anal., 45: 243-250.
CrossRef | PubMed | Direct Link | - Hamza, A.A., A. Amin and S. Daoud, 2007. The protective effect of a purified extract of Withania somnifera against doxorubicin-induced cardiac toxicity in rats. Cell Biol. Toxicol., 24: 63-73.
CrossRef | PubMed | Direct Link | - Hamza, A.A., 2007. Curcuma longa, Glycyrrhiza glabra and Moringa oleifera ameliorate diclofenac-induced hepatoxicity in rats. Am. J. Pharmacol. Toxicol., 2: 80-88.
Direct Link | - Hamza, A.A. and A. Amin, 2007. Apium graveolens modulates sodium valproate-induced reproductive toxicity in rats. J. Exp. Zool. Part A. Ecol. Genet. Physiol., 307: 199-206.
CrossRef | PubMed | Direct Link | - Al-Akhras, M.A.H., A. Amin, K. Mohammad, F. Al-Haddad and A. Hamza, 2007. In vitro studies on the effect of phototoxicity of a new photosensitizer extracted from flowers and aerial parts of Cichorium pumilum. Am. J. Pharmacol. Toxicol., 2: 39-45.
CrossRef | Direct Link | - Amin, A., A.A Hamza, S. Daoud and W. Hamza, 2006. Spirulina protects against cadmium-induced hepatotoxicity in rats. Am. J. Pharmacol. Toxicol., 1: 21-25.
CrossRef | Direct Link | - Amin, A. and A.A. Hamza, 2006. Effects of Roselle and Ginger on cisplatin-induced reproductive toxicity in rats. Asian J. Androl., 8: 607-612.
CrossRef | PubMed | Direct Link | - Amin, A. and A.A. Hamza, 2005. Oxidative stress mediates drug-induced hepatotoxicity in rats: A possible role of DNA fragmentation. Toxicology, 208: 367-375.
CrossRef | PubMed | Direct Link | - Amin, A. and A.A. Hamza, 2005. Hepatoprotective effects of Hibiscus, Rosmarinus and salvia on azathioprine-induced toxicity in rats Life Sci., 77: 266-278.
CrossRef | PubMed | Direct Link | - Abou-Basha, L.I., L.F. Wahman, A. Hamza and H.Y. Aboul-Enein, 2005. Pharmacokinetics of theophylline after administration of suppositories formulation. J. Immunoassay Immunochem., 26: 251-258.
CrossRef | Direct Link | - El-Ridi, M.R., G.S.Y. Hanna and A. Hamza, 2003. Selenium supplementation improves dyslipidemia, lipid peroxidation and impaired cardiac performance in preeclamptic rats. Minoufiya Med. J., 16: 162-173.
- Hamza, A.A. and A.Z. Taha, 1995. Performance of submersible PV solar pumping systems under conditions in the Sudan. Renewable Energy, 6: 491-495.
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