Dr. Laila A. Abouzeid
My Social Links

Dr. Laila A. Abouzeid

Assistant Professor
Faculty of Pharmacy, Mansoura University Faculty of Pharmacy, Delta University Mansoura, Egypt


Highest Degree
Ph.D. in Pharmacy from Mansoura University, Egypt

Share this Profile

Area of Interest:

Pharmacology and Toxicology
100%
Pharmaceutical Sciences
62%
Medicinal Chemistry
90%
Molecular Structure
75%
Antiinflamatory
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
0
Abstracts
0

Selected Publications

  1. Al-Turki, D.A., M.A. Al-Omar, L.A. Abou-Zeid, I.A. Shehata and M.S. Al-Awady, 2017. Design, synthesis, molecular modeling and biological evaluation of novel diaryl heterocyclic analogs as potential selective cyclooxygenase-2 (COX-2) inhibitors. Saudi Pharmaceut. J., 25: 59-69.
    CrossRef  |  Direct Link  |  
  2. Osama, L., L.A. Abou-Zeid, M.N.A. Nasr and A.S. Tantawy, 2016. Synthesis and molecular modeling of new quinoline derivatives as antitumor agents. Der Pharma Chemica, 8: 100-110.
    Direct Link  |  
  3. Alaa, A.M., L.A. Abou-Zeid, K.E.H. ElTahir, R.R. Ayyad, A.A. Magda and A.S. El-Azab, 2016. Synthesis, anti-inflammatory, analgesic, COX-1/2 inhibitory activities and molecular docking studies of substituted 2-mercapto-4(3H)-quinazolinones. Eur. J. Med. Chem., 121: 410-421.
    CrossRef  |  Direct Link  |  
  4. Alaa, A.M., L.A. Abou-Zeid, K.E.H. ElTahir, M.A. Mohamed, M.A.A. El-Enin and A.S. El-Azab, 2016. Design, synthesis of 2,3-disubstitued 4(3H)-quinazolinone derivatives as anti-inflammatory and analgesic agents: COX-1/2 inhibitory activities and molecular docking studies. Bioorg. Med. Chem., 24: 3818-3828.
    CrossRef  |  PubMed  |  Direct Link  |  
  5. Alaa, A.M., A.S. El-Azab, L.A. Abou-Zeid, K.E.H. ElTahir, N.I. Abdel-Aziz, R.R. Ayyad and A.M. Al-Obaid, 2016. Synthesis, anti-inflammatory, analgesic and COX-1/2 inhibition activities of anilides based on 5,5-diphenylimidazolidine-2,4-dione scaffold: Molecular docking studies. Eur. J. Med. Chem., 115: 121-131.
    CrossRef  |  Direct Link  |  
  6. Kosbar, T.R., M.A. Sofan, L. Abou-Zeid and E.B. Pedersen, 2015. Thermal stability of G-rich anti-parallel DNA triplexes upon insertion of LNA and α-L-LNA. Org. Biomol. Chem., 13: 5115-5121.
    CrossRef  |  Direct Link  |  
  7. Alter, G.M. and L. Abou-Zeid, 2015. Molecular dynamic simulation of malate dehydrogenase. SMU Med. J., 2: 270-280.
    Direct Link  |  
  8. Abouzeid, L.A. and H.I. El-Subbagh, 2015. DNA binding of ethyl 2-substituted aminothiazole-4-carboxylate analogues: A molecular modeling approach to predict their antitumor activity. Future J. Pharmaceut. Sci., 1: 1-7.
    CrossRef  |  Direct Link  |  
  9. Abou-Zeid, L.A. and M. Hefnawy, 2015. Molecular modeling study of the chiral recognition of celiprolol enantiomers by a β-cyclodextrin. Pharmaceut. Chem. J., 2: 16-23.
    Direct Link  |  
  10. Henen, M.A., L. Abou-Zeid, A.E.D. Barghash and H. Eisa, 2014. 19F-NMR as a powerful tool for measuring binding of synthesized small combinatorial dynamic library components with the armadillo repeat domain of human β-catenin. Curr. Top. Pept. Protein Res., 15: 35-39.
    Direct Link  |  
  11. El-Feky, S.M., L.A. Abou-Zeid, M.A. Massoud, S.K. George and H.M. Eisa, 2014. Computational design, molecular modeling and synthesis of new 1,2,4-triazole analogs with potential antifungal activities. SMU Med. J., 1: 224-242.
    Direct Link  |  
  12. Abou-Zeid, L. and H.N. Baraka, 2014. Combating oxidative stress as a hallmark of cancer and aging: Computational modeling and synthesis of phenylene diamine analogs as potential antioxidant. Saudi Pharmaceut. J., 22: 264-272.
    CrossRef  |  Direct Link  |  
  13. Shuhnna, M., A. Dauood, L. Abouzeid and O. Khudro, 2013. Synthesis and molecular modeling for novel derivative of benzodiazepines and determine the structure using spectrum methods. Res. J. Aleppo Univ., 88: 49-53.
  14. Shuhnna, M., A. Dauood, L. Abouzeid and O. Khudro, 2013. Analytical method validation and stability study for novel derivative of benzodiazepines. Res. J. Aleppo Univ., 88: 45-48.
  15. Kosbar, T., M. Sofan, L. Abou-Zeid, M. Waly and E.B. Pedersen, 2013. Highly efficient synthesis of allopurinol locked nucleic acid monomer by C6 deamination of 8-aza-7-bromo-7-deazaadenine locked nucleic acid monomer. Synthesis, 45: 3259-3262.
    CrossRef  |  Direct Link  |  
  16. Henen, M.A., L. Abou-Zeid, A.E.D. Barghash and H.M. Eisa, 2013. Nuclear magnetic resonance as a breakthrough frontier in fragment-based drug design. J. Am. Sci., 9: 459-466.
    Direct Link  |  
  17. Bayomi, S.M., H.A. El-Kashef, M.B. El-Ashmawy, M.N.A. Nasr and M.A. El-Sherbeny et al., 2013. Synthesis and biological evaluation of new curcumin derivatives as antioxidant and antitumor agents. Med. Chem. Res., 22: 1147-1162.
    CrossRef  |  Direct Link  |  
  18. Waly, M.A., L. Abou-Zeid, S.R. El-Gogary and M.A. Shalaby, 2012. One-pot synthesis, molecular modeling and in vitro antibacterial activity of novel 3-(1,3,4-oxadiazol-2-yl)quinoxaline 1,4-dioxide and pyrazolyl analogs. Acta Chimica Slovenica, 59: 32-41.
    Direct Link  |  
  19. El Sayed, M.A.A., M.A. Massoud, A.S. Tantawy, M.N.A. Nasr, A.E.D.M. Barghash and L.A. Abou-Zeid, 2012. Synthesis and biological evaluation of new unsaturated derivatives of cyclic compounds as potent antioxidant agent. Der Pharma Chemica, 5: 1785-1797.
    Direct Link  |  
  20. Bayoumi, W.A., M.A. Elsayed, H.N. Baraka and L. Abou-Zeid, 2012. Computational modeling, synthesis and antioxidant potential of novel phenylcarbamoylbenzoic acid analogs in combating oxidative stress. Archiv Pharmazie, 345: 902-910.
    CrossRef  |  Direct Link  |  
  21. Youssef, K.M., M.A. Al-Omar, H.I. El-Subbagh, L.A. Abou-Zeid, A.G.M. Abdel-Gader, N.G. Haress and A.S. Al-Tuwaijri, 2011. Synthesis, antiplatelet aggregation activity and molecular modeling study of novel substituted-piperazine analogues. Med. Chem. Res., 20: 898-911.
    CrossRef  |  Direct Link  |  
  22. El-Feky, S.M., L.A. Abou-Zeid, M.A. Massoud, S.K. George and H.M. Eisa, 2010. Synthesis, molecular modeling of novel 1,2,4-triazole derivatives with potential antimicrobial and antiviral activities. Acta Pharmaceutica Sciencia, 52: 353-364.
  23. Al-Turki, D.A., L.A. Abou-Zeid, I.A. Shehata and M.A. Al-Omar, 2010. Therapeutic and toxic effects of new NSAIDs and related compounds: A review and prospective study. Int. J. Pharmacol., 6: 813-825.
    CrossRef  |  Direct Link  |  
  24. Al-Omary, F.A., L.A. Abou-Zeid, M.N. Nagi, E.S.E. Habib and A.M. Alaa et al., 2010. Non-classical antifolates. Part 2: synthesis, biological evaluation and molecular modeling study of some new 2,6-substituted-quinazolin-4-ones. Bioorg. Med. Chem., 18: 2849-2863.
    CrossRef  |  Direct Link  |  
  25. Goda, F.E., A.S. Tantawy, S., L.A. Abou-zeid, S.M. Badr and K.B. Selim, 2008. Synthesis, biological evaluation and molecular modeling investigation of some new benzimidazole analogs as antiviral agents. Saudi Pharm. J., 16: 103-111.
    Direct Link  |  
  26. Abou-Zeid, L.A., A.M. El-Mowafy, D. Eikel, H. Nau and M. El-Mazar, 2007. Computational characteristics of valproic acid binding to Histone deacetylase. Saudi Pharm. J., 15: 183-189.
    Direct Link  |  
  27. Abou-Zeid, L., A.M. El-Mowafy, D. Eikel, H. Nau and M.M.A. Elmazar, 2007. Mechanism of butyrate binding to histone deacetylase (HDAC): Correlation with chemopreventive effects and ligand selectivity. J. Basic Appl. Sci., 3: 73-80.
  28. Al-Rashood, S.T., I.A. Aboldahab, M.N. Nagi, L.A. Abou-zeid and A.M. Abdel-Aziz et al., 2006. Synthesis, dihydrofolate reductase inhibition, antitumor testing and molecular modeling study of some new 4(3H)-quinazolinone analogs. Bioorg. Med. Chem., 15: 8608-8621.
    PubMed  |  
  29. Abou-Zeid, L.A. and A.M. El-Mowafy, 2004. Differential recognition of resveratrol isomers by the human estrogen receptor-α: Molecular dynamics evidence for stereoselective ligand binding. Chirality, 16: 190-195.
    CrossRef  |  Direct Link  |  
  30. El-Mowafy, A.M., L.A. Abou-Zeid and I. Edafiogho, 2002. Recognition of resveratrol by the human estrogen receptor-alpha: A molecular modeling approach to understand its biological actions. Med. Principles Pract., 11: 86-92.
    CrossRef  |  Direct Link  |  
  31. Abou-Zeid, L.A., 2002. Molecular modeling studies of resveratrol as an estrogen receptor ligand. Saudi Pharm. J., 10: 60-64.
  32. Abou-Zeid, L.A. and A.M. El-Mowafy, 2002. Molecular dynamics simulation characteristics of resveratrol interaction with human estrogen receptor-α: Distinct recognition from diethylstilbestrol. J. Mol. Struct.: THEOCHEM, 593: 39-48.
    CrossRef  |  Direct Link  |  
  33. Abou-Zeid, L.A. and A.M. El-Mowafy, 2001. Antineoplastons: Major players in the biochemical defensive system against cancer. Saudi Pharmaceut. J., 9: 67-71.
  34. Abou-Zeid, L., A.M. El-Mowafy, M.M. El-Kerdawy, H. Hamza and M.E. Abdel-Hamid, 2001. Synthesis, spectroscopic characterization, stability assessment and DNA-binding of new 2,6-piperidinedione derivatives. Il Farmaco, 56: 763-770.
    CrossRef  |  Direct Link  |  
  35. Badria, F., M. Mabed, W. Khafagy and L. Abou-Zeid, 2000. Potential utility of antineoplaston A-10 levels in breast cancer. Cancer Lett., 155: 67-70.
    CrossRef  |  Direct Link  |  
  36. Badria, F., M. Mabed, M. El-Awadi, L. Abou-Zeid, E. Al-Nashar and S. Hawas, 2000. Immune modulatory potentials of antineoplaston A-10 in breast cancer patients. Cancer Lett., 157: 57-63.
    CrossRef  |  Direct Link  |  
  37. Abou-Zeid, L.A., A.M. El-Mowafy, M.B. El-Ashmawy, L.B. Hendry, A.M. Abdelal and F.A. Badria, 2000. Novel piperidinedione analogs as inhibitors of breast cancer cell growth. Archiv Pharmazie, 333: 431-434.
    PubMed  |  
  38. El-Kerdawy, M.M., A.S. Tantawy, M.A.M. Massoud and L.A. Abou-Zeid, 1999. Synthesis and antithyroid activity of certain uracil and thiouracil derivatives. Alexandria J. Pharmaceut. Sci., 13: 121-124.
  39. El-Kerdawy, M.M., A.S. Tantawy, M.A. Massoud and L.A. Abou-Zeid, 1999. Synthesis and antithyroid activity of certain uracil derivatives (part II). Mansoura Sci. Bull., 26: 133-140.