Prof. Wael Mohamed El-Sayed

Prof. Wael Mohamed El-Sayed

Professor
Ain Shams University, Egypt


Highest Degree
Ph.D. in Animal Physiology and Pharmacology from University of Utah, Salt Lake City, Utah, USA

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Biography

Dr. Wael M. El-Sayed is currently working as a Professor of Animal Physiology at Ain Shams University, Cairo, Egypt. He obtained his PhD from Ain Shams University, Egypt and College of Pharmacy, University of Utah, Salt Lake City, Utah, USA. In past he worked as Demonstrator, Assistant lecturer, Assistant Professor, Associate Professor at Ain Shams University, Cairo, Egypt, Post-Doctoral fellow at the University of Utah, USA, Associate Professor at King Faisal University, AlHasaa, Kingdom of Saudi Arabia. His research interest focused on several issues; Natural products including plant and animal sources, Drug-drug Interaction and drug metabolism, Evaluation of novel drugs, Chemoprotection and Chemoprevention strategies in cancer, Antioxidants, Molecular Biology and Biotechnology. He is a member of different scientific communities, Editor of Asian Council of Science, Webmed Central global advisory board, Saudi Biological Society, Society of Toxicology, Egyptian Syndicate of Scientific Professions, Egyptian Society of Zoology, and Egyptian-German Society of Zoology. He actively participated in a number of conferences. He is a member of the editorial board and reviewer of many national and international journals. He is supervising 15 Ph.D. and 17 MSc students' theses. He has published more than 50 research articles in journals and delivered 31 presentations at international conferences.

Area of Interest:

Pharmacology and Toxicology
100%
Physiology
62%
Toxicology
90%
Molecular Biology
75%
Natural Product
55%

Selected Publications

  1. Shahat, A.S., W.A. Hassan and W.M. El-Sayed, 2020. N-Acetylcysteine and Safranal prevented the brain damage induced by hyperthyroidism in adult male rats. Nutr. Neurosci., 10.1080/1028415X.2020.1743917.
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  2. Hekal, M.H., A.M. El-Naggar, F.S.M.A. El-Azm and W.M. El-Sayed, 2020. Synthesis of new oxadiazol-phthalazinone derivatives with anti-proliferative activity; molecular docking, pro-apoptotic, and enzyme inhibition profile. RSC Adv., 10: 3675-3688.
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  3. Alshinnawy, A.S., W.M. EL-Sayed, A.M. Taha, A.A. Sayed and A.M. Salem, 2020. Astragalus membranaceus and Punica granatum alleviate infertility and kidney dysfunction induced by aging in male rats. Turk. J. Biol., 10.3906/biy-2001-5.
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  4. Salem, M.S., R.A. Hussein and W.M. El-Sayed, 2019. Substitution at phenyl rings of chalcone and schiff base moieties accounts for their antiproliferative activity. Anti Cancer Agent Med. Chem., 19: 620-626.
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  5. Ramadan, D.T., M.A.M. Ali, S.M. Yahya and W.M. El-Sayed, 2019. Correlation between antioxidant/antimutagenic and antiproliferative activity of some phytochemicals. Anti Cancer Agent Med. Chem., 19: 1481-1490.
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  6. Mahmoud, A.A. and W.M. El-Sayed, 2019. The anti-proliferative activity of anisosciadone: A new guaiane sesquiterpene from Anisosciadium lanatum. Anti Cancer Agent Med. Chem., 19: 1114-1119.
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  7. Ismail, M.A., W.M. El-Sayed, S. Shaaban, G.A. Abdelwahab and W.S. Hamama, 2019. A review of cationic arylfurans and their isosteres: synthesis and biological importance. Curr. Org. Chem., 23: 2751-2782.
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  8. Ismail, M.A., A. Negm, R.K. Arafa, E. Abdel-Latif and W.M. El-Sayed, 2019. Anticancer activity, dual prooxidant/antioxidant effect and apoptosis induction profile of new bichalcophene-5-carboxamidines. Eur. J. Med. Chem., 169: 76-88.
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  9. El-hashash, M.A., A.T. Ali, R.A. Hussein and W.M. El-Sayed, 2019. Synthesis and reactivity of 6,8-dibromo-2-ethyl-4H-benzo[d][1,3]oxazin-4-one towards nucleophiles and electrophiles and their anticancer activity. Anti Cancer Agent Med. Chem., 19: 538-545.
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  10. El-Metwally, A.S., A.K. Khalil and W.M. El-Sayed, 2019. Design, molecular modeling and anticancer evaluation of thieno[2,3-d]pyrimidine derivatives as inhibitors of topoisomerase II. Bioorg. Chem., 10.1016/j.bioorg.2019.103492.
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  11. Abdel-Rasol, M., N.M. El-Beih, S.M.M. Yahya, M.A. Ismail and W.M. El-Sayed, 2019. The antitumor activity of a novel fluorobenzamidine against dimethylhydrazine- induced colorectal cancer in rats. Anti Cancer Agent Med. Chem., 20: 450-463.
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  12. Shaaban, R., W.M. El-Sayed, S. Samir and E. El-Dabaa, 2018. Molecular and biological characterization of a prepared recombinant human interferon alpha 2b isoform. Appl. Biochem. Biotechnol., 188: 72-86.
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  13. El-Metwally, S.A., A.K. Khalil, A.M. El-Naggar and W.M. El-Sayed, 2018. Novel tetrahydrobenzo [b] thiophene compounds exhibit anticancer activity through enhancing apoptosis and inhibiting tyrosine kinase. Anti Cancer Agent Med. Chem., 18: 1761-1769.
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  14. El-Maraghi, E.F., K.I. Abdel-Fattah, S.M. Soliman and W.M. El-Sayed, 2018. Taurine provides a time-dependent amelioration of the brain damage induced by γ-irradiation in rats. J. Hazard. Mater., 359: 40-46.
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  15. El-Hashash, M.A., E.A. El-Bordany, M.I. Marzouk, A.M. El-Naggar, T.M.S. Nawar and W.M. El-Sayed, 2018. Novel nicotinonitrile derivatives bearing imino moieties enhance apoptosis and inhibit tyrosine kinase. Anti Cancer Agent Med. Chem., 18: 1589-1598.
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  16. Nour-Eldein, N.H., El.S.A. Hassanin and W.M. El-Sayed, 2017. Mitigation of acute aluminum toxicity by sodium selenite and N-acetylcysteine in adult male rats. Biol. Trace Elem. Res., 183: 128-137.
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  17. Ismail, M.A., M.M. Youssef, R.K. Arafa, S.S. Al-Shihry and W.M. El-Sayed, 2017. Synthesis and antiproliferative activity of monocationic arylthiophene derivatives. Eur. J. Med. Chem., 126: 789-798.
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  18. Hussein R.A., W.M. El-Sayed and E.A. El-Hussieny, 2017. The prophylactic and therapeutic effects of safranal and selenite on liver damage induced by thyrotoxicosis in adult male rats. Int. J. Clin. Pharm. Toxicol., 6: 270-279.
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  19. El-Sayed, W.M., W.A. Hussin, A.A. Mahmoud and M.A. AlFredan, 2017. Antimutagenic activities of Anisosciadium lanatum extracts could predict the anticancer potential in different cell lines. Int. J. Pharmaceut. Phytopharmacol. Res., 9: 197-206.
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  20. El-Sayed, W.M., A. El-Naggar, A. Khalil and H. Zeidan, 2017. Eco-friendly synthesis of pyrido [2, 3-d] pyrimidine analogs and their anticancer and tyrosine Kinase inhibition activities. Anti-Cancer Agents Med. Chem. .
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  21. Rashed, H., 2016. The growth hormone deficiency short stature is the predominant type among young school girls in Gaza, Palestine. Int. J. Adv. Res., 4: 283-290.
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  22. Mahmoud, A.A., M.A. AlFredan and W.M. El-Sayed, 2016. Isolation, Characterization and Anticancer Activity of Seven Compounds from the Aerial Parts of Conyza triloba. Int. J. Pharmaceut. Phytopharmacol. Res., 8: 2071-2079.
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  23. Ismail, M.A., R.K. Arafa, M.M. Youssef and W.M. El-Sayed, 2014. Anticancer, antioxidant activities and DNA affinity of novel monocationic bithiophenes and analogues. Drug Design Dev. Ther., 8: 1695-1702.
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  24. Hussin, W.A., M.A. Ismail, A.M. Alzahrani and W.M. El-Sayed, 2014. Evaluation of the biological activity of novel monocationic fluoroaryl-2,2′-bichalcophenes and their analogues. Drug Design Dev. Ther., 8: 963-972.
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  25. Al Kahtani, M.A., A.M. Abdel-Moneim and W.M. El-Sayed, 2014. The influence of taurine pretreatment on aluminum chloride induced nephrotoxicity in Swiss albino mice. Histol. Histopathol., 29: 45-55.
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  26. Hussin, W.A., M.A. Ismail and W.M. El-Sayed, 2013. Novel 4-substituted phenyl-2,2'-bichalcophenes and aza-analogs as antibacterial agents: A structural activity relationship. Drug Design Dev. Ther., 7: 185-193.
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  27. El-Sayed, W.M., W.M. Hussin, A.A. Mahmoud and M.A. AlFredan, 2013. The Conyza triloba extracts with high chlorophyll content and free radical scavenging activity had anticancer activity in cell lines. Biomed. Res. Int. 10.1155/2013/945638.
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  28. El-Sayed, W.M., W.A. Hussin, Y.S. Al-Faiyz and M.A. Ismail, 2013. The position of imidazopyridine and metabolic activation are pivotal factors in the antimutagenic activity of novel imidazo[1,2-a]pyridine derivatives. Eur. J. Pharmacol., 715: 212-218.
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  29. El-Sayed, W.M. and W.A. Hussin, 2013. Antimutagenic and antioxidant activity of novel 4-substituted phenyl-2,2′-bichalcophenes and aza-analogs. Drug Design Dev. Ther., 7: 73-81.
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  30. El-Sayed, W.M., W.A. Hussin and M.A. Ismail, 2012. Efficacy of Two Novel 2,2’-Bifurans to Inhibit Methicillin-Resistant Staphylococcus Aureus Infection in Male Mice in Comparison to Vancomycin. Drug Des. Dev. Ther., 6: 279-287.
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  31. Ramadan, G., M.A. Al-Kahtani and W.M. El-Sayed, 2011. Anti-inflammatory and anti-oxidant properties of Curcuma longa (Turmeric) Versus Zingiber officinale (Ginger) Rhizomes in Rat adjuvant-induced arthritis. Inflammation, 34: 291-301.
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  32. Hussin, W.A. and W.M. El-Sayed, 2011. Synergic Interactions Between Selected Botanical Extracts and Tetracycline Against Gram Positive and Gram Negative Bacteria. J. Biol. Sci., 11: 433-441.
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  33. El-Sayed, W.M., M.A. Al-Kahtani and A.M. Abdel-Moneim, 2011. Prophylactic and Therapeutic Effects of Taurine Against Aluminum-Induced Acute Hepatotoxicity in Mice. J. Hazard. Mater., 192: 880-886.
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  34. El-Sayed, W.M., 2011. Upregulation of Chemoprotective Enzymes and Glutathione by Nigella Sativa (Black Seed) and Thymoquinone in CCl4-Intoxicated Rats. Int. J. Toxicol., 30: 707-714.
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  35. El-Sayed, W.M., 2011. Effect of Pregnane X Receptor (PXR) Prototype Agonists on Chemoprotective and Drug Metabolizing Enzymes in Mice. Eur. J. Pharmacol., 660: 291-297.
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  36. El-Sayed, W.M. and M.A. Al-Kahtani, 2011. Potential Adverse Effects of Oseltamivir in Rats: Males are More Vulnerable Than Females. Can. J. Physiol. Pharmacol., 89: 623-630.
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  37. El-Sayed, W.M., T. Aboul-Fadl and M.R. Franklin, 2010. Effects of isatin-isoniazid derivatives on drug metabolizing and chemoprotective enzymes in mice. Drug Dev. Res., 71: 313-322.
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  38. El-Sayed, W.M., 2008. Effect of three herbal extracts on mRNA levels of some drug-metabolizing enzymes in murine hepatoma cells. Egypt. J. Zool., 50: 269-289.
  39. Franklin, M.R., P.J. Moos, W.M. El-Sayed, T. Aboul-Fadl and J.C. Roberts, 2007. Pre- and post-initiation chemoprevention activity of 2-alkyl/aryl selenazolidine-4(R)-carboxylic acids against tobacco-derived nitrosamine (NNK)-induced lung tumors in the A/J mouse. Chemico-Biol. Interact., 168: 211-220.
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  40. El-Sayed, W.M., W.A. Hussin and M.R. Franklin, 2007. The anti-mutagenicity of 2-substitiuted selenazolidine-4-(R)-carboxylic acids. Mutation Res., 627: 136-145.
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  41. El-Sayed, W.M., T. Aboul-Fadl, J.C. Roberts, J.G. Lamb and M.R. Franklin, 2007. Murine hepatoma (Hepa1c1c7) cells: A responsive in vitro system for chemoprotective enzyme induction by organoselenium compounds. Toxico. Vitro, 21: 157-164.
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  42. El-Sayed, W.M. and M.R. Franklin, 2007. Hepatic chemoprotective enzyme responses to 2-substituted selenazolidine-4(R)-carboxylic acids. J. Biochem. Mol. Toxicol., 20: 292-301.
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  43. Li, L., Y. Xie, W.M. El-Sayed, J.G. Szakacs, M.R. Franklin and J.C. Roberts, 2006. Chemopreventive activity of selenocysteine prodrugs against tobacco-derived nitrosamine (NNK)-induced lung tumors in the A/J mouse. J. Biochem. Mol. Toxicol., 19: 396-405.
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  44. El-Sayed, W.M., T. Aboul-Fadl, J.G. Lamb, J.C. Roberts and M.R. Franklin, 2006. Acute effects of novel selenazolidines on murine chemoprotective enzymes. Chem. Biol. Interact., 162: 31-42.
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  45. El-Sayed, W.M., T. Aboul-Fadl, J.G. Lamb, J.C. Roberts and M.R Franklin, 2006. Effect of selenium-containing compounds on hepatic chemoprotective enzymes in mice. Toxicology, 220: 179-188.
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  46. Li, L., Y. Xie, W.M. El-Sayed, J.G. Szakacs and J.C. Roberts, 2004. Characteristics of selenazolidine prodrugs of selenocysteine: Toxicity, selenium levels and glutathione peroxidase induction in A/J mice. Life Sci., 75: 447-459.
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