Dr. Siham Mostafa Ali EL-Shenawy
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Dr. Siham Mostafa Ali EL-Shenawy

Professor Researcher
National Research Center, Egypt


Highest Degree
M.D. in Clinical Toxicology from Ain Shams University, Egypt

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Area of Interest:

Pharmacology and Toxicology
100%
Pharmacological Research
62%
Experimental Therapeutics
90%
Inflammopharmacology
75%
Phytochemistry
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
0
Abstracts
0

Selected Publications

  1. Moharram, F.A.E., A.A. Al-Gendy, S.M. El-Shenawy, B.M. Ibrahim and M.A. Zarka, 2018. Phenolic profile, anti-inflammatory, antinociceptive, anti-ulcerogenic and hepatoprotective activities of Pimenta racemosa leaves. BMC Complement. Altern. Med., Vol. 18. 10.1186/s12906-018-2260-3.
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  2. Moharram, F.A., R.A.E.M. El Dib, M.S. Marzouk, S.M. El-Shenawy and H.A. Ibrahim, 2017. New apigenin glycoside, polyphenolic constituents, anti-inflammatory and hepatoprotective activities of Gaillardia grandiflora and Gaillardia pulchella aerial parts. Pharmacogn. Magaz., 13: S244-S249.
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  3. Moharram, F.A., R.A. El Dib, L.F. Wahman, S.M. El-Shenawy and S. El-Awdan, 2017. Gastro protective effect of pentagalloyl glucose on aspirin induced gastric mucosal ulcer in comparison with omeprazole, famotidine and melatonin. J. Pharm. Sci. Res., 9: 785-795.
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  4. Kenawy, S., R. Hegazy, A. Hassan, S. El-Shenawy, N. Gomaa, H. Zaki and A. Attia, 2017. Involvement of insulin resistance in D-galactose-induced age-related dementia in rats: Protective role of metformin and saxagliptin. PLoS One, Vol. 12. 10.1371/journal.pone.0183565.
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  5. El-Madani, M., O. Colomban, M. Tod, D. Maillet and J. Peron et al., 2017. EVESOR, a model-based, multiparameter, phase I trial to optimize the benefit/toxicity ratio of everolimus and sorafenib. Future Oncol., 13: 679-693.
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  6. El Madani, M.A., R.M. Abd El Salam, A.S. Attia, S.M. El-Shenawy and M.S. Arbid, 2016. Neuropharmacological effects of naringenin, harmine and adenosine on parkinsonism induced in rats. Der. Pharm. Lett., 8: 45-57.
  7. Desoukey, S.Y., W.M. El Kady, A.A.A. Salama, E.G. Hagag, S.M. El-Shenawy and M.A. El-Shanawany, 2016. Hepatoprotection and antioxidant activity of gazania longiscapa and G. rigens with the isolation and quantitative analysis of bioactive metabolites. Int. J. Pharm. Phytochem. Res., 8: 1121-1131.
  8. Yassin, N.Z., S.M. El-Shenawy, R.F. Abdel-Rahman, M. Yakoot, M. Hassan and S. Helmy, 2015. Effect of a topical copper indomethacin gel on inflammatory parameters in a rat model of osteoarthritis. Drug Design Dev. Therapy, 9: 1491-1498.
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  9. Salama, A.A.A., H.F. Zaki, S.M. El-Shenawy, E.S.M. El-Denshary and I.E.K. Ismaiel, 2015. Antiasthmatic effects of evening primrose oil in ovalbumin-allergic rats. Der. Pharm. Lett., 7: 214-223.
  10. Moharram, F.A.E., M.S. Marzouk, R.A.M. El Dibl, S.M. El-Shenawy, R.F. Abdel-Rahman and R.R. Ibrahim, 2015. Hepatoprotective, gastroprotective, antioxidant activity and phenolic constituents of Quercus robur leaves. J. Pharm. Sci. Res., 7: 1055-1065.
  11. El-Sayed, M.A., N.A. Yassin, A.A. Shabaka, O.A. El-Shabrawy and S.S. Mahmoud et al., 2015. Toxicological and pharmacological assessment of gold nanorods in normal rats. Int. J. Pharm. Pharm. Sci., 7: 41-50.
  12. El-Naggar, M.E., H.M. El-Fayoumi, N.N. El-Maraghy, W. El-Eraky and S.M. El-Shenawy, 2015. Toxicological study of Zaleplon (Anxiolytic drug) in experimental animals. Zagazig J. Pharm. Sci., 23: 16-33.
  13. El Kady, W.M., A.A. Salama, S.Y. Desoukey, E.G. Hagag, S.M. El-Shenawy and M.A. El-Shanawany, 2015. Comparative DNA profiling, botanical identification and biological evaluation of Gazania longiscapa DC and Gazania rigens L. Bull. Faculty Pharm. Cairo Univ., 53: 129-145.
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  14. Salama, A., B. Elsayeh, I. Ismaiel and S. El-Shenawy, 2014. Comparative evaluation of protective effects of green tea and lycopene in potassium dichromate-induced acute renal failure in rats. J. Chem. Pharm. Res., 6: 168-177.
  15. Said, A., A.M. El-Fishawy, S. El-Shenawy, U.W. Hawas and M. Aboelmagd, 2014. Hepatoprotective and gastroprotective studies of terminalia arjuna leaves extract and phytochemical profile. Banat's J. Biotechnol., 5: 30-36.
  16. Mahdy, K.A., N.A.M. Gouda, A.E.F.H. Marrie, N.A. Yassin, S.M. El-Shenawy, A.R.H. Farrag and B.M.M. Ibrahim, 2014. Protective effect of ginger (Zingiber officinale) on Alzheimer's disease induced in rats. J. Neuroinfect. Dis., Vol. 5. .
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  17. El-Marasy, S.A., H.M. Abdallah, S.M. El-Shenawy, A.S. El-Khatib, O.A. El-Shabrawy and S.A. Kenawy, 2014. Anti-depressant effect of hesperidin in diabetic rats. Can. J. Physiol. Pharmacol., 92: 945-952.
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  18. El Dib, R.A., A.H. Gaara, S.M. El-Shenawy, J.A.A. Micky, A.A. Mohammed and M.S. Marzouk, 2014. Leaf extract of markhamia platycalyx: Polyphenolic profile, acute toxicity, anti-inflammatory, hepatoprotective and in vitro antioxidant activities. Drug Res., 64: 680-689.
  19. Yassin, N.A., S.M. El-Shenawy, K.A. Mahdy, N.A. Gouda, A.E. Marrie, A.R. Farrag and B.M. Ibrahim, 2013. Effect of Boswellia serrata on Alzheimer's disease induced in rats. Arab Soc. Med. Res., 8: 1-11.
  20. El-Shenawy, S.M., N.A. Yassin, O.A. Badary, M. El-Moneem and H.M. Al-Shafeiy, 2013. Study of the effect of Allium porrum on osteoporosis induced in rats. Der Pharm. Lett., 5: 188-198.
  21. El-Sayed, M.A., A.A. Shabaka, O.A. El-Shabrawy, N.A. Yassin and S.S. Mahmoud et al., 2013. Tissue distribution and efficacy of gold nanorods coupled with laser induced photoplasmonic therapy in ehrlich carcinoma solid tumor model. PloS One, Vol. 8. 10.1371/journal.pone.0076207.
    CrossRef  |  
  22. Badary, O.A., N.A. Yassin, S. El-Shenawy, M.A. El-Moneem and H.M. Al-Shafeiy, 2013. Study of the effect of Allium porrum on hypertension induced in rats. Revista Latinoamericana de Quimica, 41: 149-160.
  23. Yassin, N.A.Z., E.S. M. ElRokh, S.M.A. El-Shenawy and B.M.M. Ibrahim, 2012. The study of the antispasmodic effect of Ginger (Zingiber officinale) in vitro. Der Pharmacia Lettre, 4: 263-274.
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  24. Salama, A.A.A., H.F. Zaki, S.M. El-Shenawy, E.S.M. El-Denshary, I.E.K. Ismaiel and N.M. Shaffie, 2012. Effects of fish oil and dexamethasone in experimentally induced bronchial asthma. Aust. J. Basic Applied Sci., 6: 497-506.
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  25. Moharram, F.A., M.S. Marzouk, S.M. El-Shenawy, A.H. Gaara and W.M. El Kady, 2012. Polyphenolic profile and Biological activity of Salvia splendens leaves. J. Pharm. Pharmacol., 64: 1678-1687.
    CrossRef  |  PubMed  |  
  26. Ismaiel, K. and M. Shaffie, 2012. Effects of fish oil and dexamethasone in experimentally-induced bronchial asthma. Aust. J. Basic Applied Sci., 6: 497-506.
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  27. El-Marasy, S.A., S.M. El-Shenawy, A.S. El-Khatib, O.A. El-Shabrawy and S.A. Kenawy, 2012. Effect of Nigella sativa and wheat germ oils on scopolamine-induced memory impairment in rats. Bull. Faculty Pharm. Cairo Univ., 50: 81-88.
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  28. Yassin, N.A.Z., E.M. Elrokh, S.M.A. El-Shenawy, N.A. Ehasn, W.H. Sayed, H.M.D.E. Hassanein and B.M.M. Ibrahim, 2010. Study of the hepatoprotective effect of ginger aqueous infusion in rats. J. Chem. Pharm. Res., 2: 476-488.
  29. Said, A., U.W. Hawas, S. El-Shenawy, S.M. Nofal and K. Rashed, 2010. Flavonoids from Ailanthus excelsa leaves with some biological activities. IUFS J. Biol., 69: 41-55.
  30. ElRokh, E.S.M., N.A. Yassin, S.M. El-Shenawy and B.M. Ibrahim, 2010. Antihypercholesterolaemic effect of ginger rhizome (Zingiber officinale) in rats. Inflammopharmacol., 18: 309-315.
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  31. Radwan, M.A., M.A. Shehab and S.M. El-Shenawy, 2009. Synthesis and biological evaluation of 5-substituted benzo [b] thiophene derivatives as anti-inflammatory agents. Monatshefte fur Chemie-Chemical Monthly, 140: 445-450.
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  32. Marzouk, M.S., F.A. Moharram, R.A. El Dib, S.M. El-Shenawy and A.F. Tawfike, 2009. Polyphenolic profile and bioactivity study of Oenothera speciosa Nutt. aerial parts. Molecules, 14: 1456-1467.
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  33. Fakhr, I.M., M.A. Radwan, S. El-Batran, O.M. Abd el-Salam and S.M. El-Shenawy, 2009. Synthesis and pharmacological evaluation of 2-substituted benzo[b]thiophenes as anti-inflammatory and analgesic agents. Eur. J. Med. Chem., 44: 1718-1725.
    PubMed  |  
  34. El-Shenawy, S.M., 2009. Evaluation of some pharmacological activities of ethanol extracts of seeds, pericarp and leaves of Eugenia Jamolana in rats. Inflammopharmacology, 17: 85-92.
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  35. El Dib, R.A., M.S. Marzouk, F.A. Moharram, S.M. El-Shenawy and R.M. Abd Elazee, 2009. Chemical and biological investigation of Calothamnus quadrifidus. Bull. Fac. Pharm. Cairo. Univ., 47: 161-169.
  36. El-Shenawya, S.M., M.S. Marzouk, R.A. El Dib, H.A. Elyazed, N.S. Shaffie and F.A. Moharram, 2008. Polyphenols and biological activities of Feijoa sellowiana leaves and twigs. Rev. Latinoamer. Quim, 36: 1031-1040.
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  37. El-Shenawy, S.M.A. and N.S. Hassan, 2008. Comparative evaluation of the protective effect of selenium and garlic against liver and kidney damage induced by mercury chloride in the rats. Pharmacol. Rep., 60: 199-208.
    PubMed  |  
  38. El Dib, R.A. and S.M. El-Shenawy, 2008. Phenolic constituents and biological activities of the aerial parts of Callistemon viminalis (Sol. Ex Gaertner) G. Don ex Loudon. Bull. Faculty Pharm. (Cairo Univ.), 46: 223-235.
  39. Abdel-Salam, O.M.E., S.M. Nofal, S.M. El-Shenawy and N.M. Shaffie, 2008. The effect of interferon alone or combined with silymarin on liver and bone parameters in bile duct ligated rats. Int. J. Pharmaco., Vol. 6. .
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  40. Abdel-Salam, O.M.E., S.M. Nofal, S.M. El-Shenawy and N.M. Shaffie, 2008. Effect of piperine on liver damage and bone changes caused by bile duct ligation in rats. Int. J. Pharmacol., .
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  41. Saiam, O.M.A., E.S. Siham, S.M. Nofal and M. Gy, 2007. Piperine inhibits visceral pain caused by acetic acid in mice. J. Pharmacol. Toxicol., 2: 456-464.
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  42. Radwan, M.A., E.A. Ragab, N.M. Sabry and S.M. El-Shenawy, 2007. Synthesis and biological evaluation of new 3-substituted indole derivatives as potential anti-inflammatory and analgesic agents. Bioorganic Med. Chem., 15: 3832-3841.
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  43. Moharram, F.A. and S.M. El-Shenawy, 2007. Antinociceptive and anti-inflammatory steroidal saponins from Dracaena ombet. Planta Med., 73: 1101-1106.
  44. Abdel-Salam, O.M.E., S. El-Shenawy and S.M. Nofal, 2007. The effect of calcium channel blockers amlodipine, lacidipine and deltiazem on thermal and visceral pain in mice. Bull. N.R.C. Egypt, 32: 661-673.
  45. Abdel-Salam, O.M.E., S. El-Shenawy and S.M. Nofal, 2007. Effect of ramipril, valsartan and candesartan on thermal and visceral pain in mice. J. Pharmacol. Toxicol., 2: 533-541.
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  46. Abdel Salam, O.M.E., S.M. El-Shenawy and N.S. Hassan, 2007. Effect of taurine and its combination with melatonin on acute hepatic damage in rats. Bull. N.R.C. Egypt, 32: 101-111.
  47. Abdel Salam, O.M.E., S. EL-Shenawy and S.M. Nofal, 2007. Effect of ramipril, valsartan, candesartan and lacidipine on inflammation and gastric ulcer in rats. Bull. N.R.C. Egypt., 32: 473-483.
  48. Abdel Salam, O.M.E., S. EL-Shenawy and S.M. Nofal, 2007. Effect of hypoglycaemia induced by different agents on thermal nociception in mice. Bull. N.R.C. Egypt, 32: 377-392.
  49. Abdel Salam, O.M.E., S. EL-Shenawy and N.M. El-Shaffie, 2007. In vivo effect of cinnarizine on acute hepatic damage in mice. Bull. N.R.C. Egypt, 32: 393-404.
  50. Abdel-Salam, O.M.E., S.M. El-Shenway, N.S. Hassan, 2006. Effect of silymarin mixed with biphenyldimethyl-dicarboxylate versus silymarin alone in liver of rats treated with carbon tetrachloride. Bull. N.R.C. Egypt, 31: 121-133.
  51. Abdel Salam, O.M., I. Hadajat, A.R. Bayomy, S. El-Shinawy and M.S. Arbid, 2006. Exposure of rats to whole body gamma rays induces early alterations in biliary secretion. Turk. J. Med. Sci., 36: 263-269.
  52. Salam, O.M.E.A., A.R. Baiuomy, S.M. El-Shenawy and N.S. Hassan, 2005. Effect of pentoxifylline on hepatic injury caused in the rat by the administration of carbon tetrachloride or acetaminophen. Pharmacol. Rep., 57: 596-603.
    PubMed  |  
  53. Abdel-Salam, O.M.E., O.A. Heikal and S.M. El-Shenawy, 2005. Effect of capsaicin on bile secretion in the rat. Pharmacology, 73: 121-128.
    CrossRef  |  
  54. Abdel-Salam, O.M., I. Hadajat, A.R. Bayomy, S. El-Shinawy and M.S. Arbid, 2005. Acute effect of gamma irradiation on gastric acid secretion and gastric mucosal integrity in the rat. Sci. World J., 5: 195-204.
    PubMed  |  
  55. Abdel-Salam, O.M., A.R. Baiuomy and S.M. El-Shenawy, 2005. Effect of cysteamine on bile secretion in the rat. Pharmacol. Rep., 57: 345-351.
    PubMed  |  Direct Link  |  
  56. Nofal, S., S.M. El-Shenawy, A.R. Baiuomy, O.M. Abd-Salam and W. El-Eraky, 2004. Comparative study of the selective cyclo-oxygenase-2 inhibitors rofexoxib and celecoxib with the non-selective cyclo-oxygenase inhibitors indomethacin and ibuprofen in rats. J. Egypt. Soc. Pharmacol. Exp. Ther., 24: 95-110.
  57. El-Batran, S.A., S.M. El-Shenawy, S.M. Nofal, O.M.E. Abdel-Salam and M.S. Arbid, 2004. Studies on the glycemic and lipidemic effect of monopril and losartan in normal and diabetic rats. Pharmacol. Res., 50: 131-136.
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  58. El Shenawy, S., A.A. Sleem and S.H. Salama, 2004. Hypolipidemic activitiy of losartan and valsartan in experimentally induced hyperlipidemia in male albino rats. J. Egypt. Soc. Pharmacol. Exp. Ther., 25: 361-373. J. Egypt. Soc. Pharmacol. Exp. Ther., 25: 361-373.
  59. Abdel-Salam, O.M.E., S.M. El-Shenawy, A.R. Baiuomy and S. Nofal, 2004. The gastric mucosal protective effects of pentoxifylline in the rat. J. Egypt Soc. Toxicol., 30: 29-34.
  60. Abdel-Salam, O.M., S.M. Nofal, A.R. Baiuomy, S.M. El-Shenawy, 2004. Evaluation of the gastric mucosal effects of different antidepressant drugs in the rat. J. Egypt Soc. Toxicol., 30: 35-43.
  61. El-Shenawy, S.M., 2003. Comparative effect of captopril and lisinopril versus losartan on inflammation. J. Egypt. Soc. Toxical., 29: 43-50.
  62. El Shenawy, S.M., 2003. Protective effect of melatonin, Silymarin and their combination in experimental induced acute hepatotoxicity. J. Egypt. Soc. Pharmacol. Exp. Ther., 23: 229-244.
  63. Abdel-Salam, O.M.E., S.M. Nofal and S.M. El-Shenawy, 2003. Evaluation of the anti-inflammatory and anti-nociceptive effects of different antidepressants in the rat. Pharmacol. Res., 49: 157-165.
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  64. Abdel-Salam, O.M.E., A.R. Baiuomy, S.M. El-Shenawy and M.S. Arbid, 2003. The anti-inflammatory effects of the phosphodiesterase inhibitor pentoxifylline in the rat. Pharmacol. Res., 47: 331-340.
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  65. El-Shenawy, S.M., S. Sawsan, F.A. Mahmoud, M.R. Moharram, EL-Gindi and A.M. Kamal, 2002. Evaluation of some pharmacological activities of leaf extracts of both Eugenia jambolana and Eugenia supra axillaries in rats of both sex. J. Egypt. Soc. Toxicol., 28: 1-12.
  66. El-Shenawy, S.M., O.M.E. Abdel-Salam, A.R. Baiuomy, S. El-Batran and M.S. Arbid, 2002. Studies on the anti-inflammatory and anti-nociceptive effects of melatonin in the rat. Pharmacol. Res., 46: 235-243.
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  67. Ameen, A., O.M. Abdel-Salam and S. El-Shenawy, 2002. Ulcerogenic effect of some newer antihypertensive drugs in rats. J. Egypt. Soc. Pharmacol. Exp. Ther., 21: 119-144.
  68. Ameen, A., O.M. Abdel-Salam and S. El-Shenawy, 2002. The influence of melatonin on gastric acid secretion and indomethacin-induced gastric ulcers in rats. J. Egypt. Soc. Pharmacol. Exp. Ther., 21: 229-248.
  69. Omar, M.E., S.E. Batran, S.E. Shenawy and S.A. Mahmoud, 2001. A protective effect for Panax ginseng in the rat stomach. J. Ginseng Res., 25: 141-149.
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  70. Nofal, S.M., S.M. El-Shenawy and M.S.S. Arbid, 2001. Evaluation of some pharmacological activities of vicine isolated from Faba beans (Vicia Faba L.) on albino rats. J. Egypt. Soc. Pharmacol. Exp. Ther., 20: 639-652.
  71. Abdel-Salam, O.M.E., S. El-Shenawy, S. El-Batran and S. Mahmoud, 2001. The effect of a selective COX-2 inhibitor on the gastric mucosa in the diabetic and steroid-treated rat. J. Egypt. Soc. Pharmacol. Exp. Ther., 20: 653-681.
  72. Abdel-Salam, O.M.E., S. El-Batran, S. El-Shenawy and M.S. Arbid, 2001. The effect of tolmetin on the rat gastric mucosa. J. Egypt. Soc. Pharmacol. Exp. Ther., 20: 505-530.
  73. Abdel-Salam, O.M., S. El-Shenawy, S. El-Batran, M.S. Arbid and G. Mazsik, 2001. The effect of etodolac on bile salt and histamine-mediated gastric mucosal injury in the rat. J. Physiol. Paris, 95: 43-49.
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