Biography

Dr. Sabry A. El-Naggar is currently working as Associate Professor in Department of Biology at Aljouf University, Saudi Arabia. He is a Faculty member at Zoology Department, Faculty of Science, Tanta University, Egypt. He completed his PhD in 2007 from Tanta University in Physiology (Immunology). His area of work includes Molecular Sciences, Immunology, Cancer Biology and Biomedical Sciences. His major interest in research is augmenting cancer-based vaccination through different approaches that can generate strong effector and memory responses of immune cells, Enhance the anti-tumor efficacy against cancer through active vaccination with ex-vivo dendritic cells pulsed with the target antigens in combination of agonists for the toll-like receptors (TLRs) expressed on dendritic cells, Augmenting T cell activation, survival, and function by cytokines such as IL-12 and TLR agonists in vitro before to use them for adoptive T cell therapy, Understanding the mechanisms underlying the beneficial effects of preconditioning a host with cyclophosphamide to adoptive T cell therapy and active vaccination, Screening the anti-cancer activity of some indigenous plants located in Kingdom of Saudi Arabia. He has published more than 20 articles in international and national peer reviewed journals and an active member in more than 10 professional scientific societies. He is also serving more than 6 journals as editor/reviewer. He is awarded the Incentive (Encouraging) National Award in Biology; Academy of Scientific Research and Technology-Egypt. He is awarded the Excellence and Quality Publishing in Aljouf University for the academic year 2013 and 2014.

Area of Interest:

Biomedical Sciences

100%

Immunoassay

62%

Cellular Immunology

90%

Host Defense

75%

Clinical Immunology

55%

Research Publications in Numbers

Books
3

Chapters
0

Articles
72

Abstracts
30

Selected Publications

Salem, M.L., S.A. El-Naggar, H.A. Mahmoud, R.M. Elgharabawy and A.M. Bader, 2018. Cyclophosphamide eradicates murine immunogenic tumor coding for a non-self-antigen and induces antitumor immunity. Int. J. Immunopathol. Pharmacol., Vol. 32. 10.1177/2058738418796591.
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El-Naggar, S.A., 2018. Comparing the effects of single and metronomic treatment with cyclophosphamide on liver and kidney functions in mice. Egypt. J. Exp. Biol. (Zool.), 14: 69-74.
El-Naggar, S., M. Ibrahim, H. El-Tantawi and I. Al-Sharkawi, 2018. Pretreatment with the micro-alga, spirulina platensis ameliorates cyclophosphamide-induced hematological, liver and kidney toxicities in male mice. Ain Shams J. Forensic Med. Clin. Toxicol., 30: 1-7.
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Salem, M.L., R.E. El Naggar, S.A. El Naggar, M.A. Mobasher, M.H. Mahmoud and G. Badr, 2017. Higher activities of hepatic versus splenic CD8+ T cells in responses to adoptive T cell therapy and vaccination of B6 mice with MHC class-1 binding antigen. Iran. J. Allergy Asthma Immunol., 16: 537-553.
El-Naggar, S.A., O. Mahalel and I. Bayoumi, 2017. Phytochemical analysis and anticancer activity of some medicinal plants grown in the kingdom of Saudi Arabia. Pak. J. Pharmaceut. Sci. (In Press). .
El-Naggar, S.A., M. Abdel Baset, H. Tantawi and A.A. Eldin, 2017. Assessment of the toxicity of sub-chronic low and high doses of the bio-insecticide, spinosad on the liver, kidney and the cerebellum in male albino mice. Brazil. Arch. Biol. Biotechnol. (In Press). .
Mohamed, M.S., A.M. Saleh, I.B. Abdel-Farid and S.A. El-Naggar, 2016. Growth, hydrolases and ultrastructure of Fusarium oxysporum as affected by phenolic rich extracts from several xerophytic plants. Pesticide Biochem. Physiol. .
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Elgebaly, H.A., I.B. Abdel-Farid, U.A. Mahalel, M. Jahangir and S.A. El-Naggar, 2016. Metabolomic profiling and antioxidant activity of Opophytum Forsskalii. Aljouf Sci. Eng. J., 3: 19-24.
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El-Naggar, S.A., I.B. Abdel-Farid, M.O. Germoush, H.A. Elgebaly and A.A. Alm-Eldeen, 2016. Efficacy of Rosmarinus officinalis leaves extract against cyclophosphamide-induced hepatotoxicity. Pharmaceut. Biol., 54: 2007-2016.
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Alm-Eldeen, A.A., S.A. El-Naggar, K.F. El-Boray, H.A. Elgebaly and I.H. Osman, 2016. Protective role of Commiphora molmol extract against liver and kidney toxicity induced by carbon tetrachloride in mice. Trop. J. Pharmaceut. Res., 15: 65-72.
El-Naggar, S.A., I.B. Abdel-Farid, H.A. Elgebaly and M.O. Germoush, 2015. Metabolomic profiling, antioxidant capacity and in vitro anticancer activity of some compositae plants growing in Saudi Arabia. Afr. J. Pharm. Pharmacol., 9: 764-774.
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El-Naggar, S.A., A.A. Alm-Eldeen, M.O. Germoush, K.F. El-Boray and H.A. Elgebaly, 2015. Ameliorative effect of propolis against cyclophosphamide-induced toxicity in mice. Pharm. Biol., 53: 235-241.
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Al-Sharkawi, M.I., A. El-Naggar, Sabry, A. E. El-Shaikh, Kamal, M. Al-Wahsh, Hany., 2014. Susceptibility of hedgehog, Hemiechinus auritus to Schistosoma mansoni under experimental infection. Res. J. Parastitol, 9: 1-10.
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Salem, M.L., A.A. Al-Khami, S.A. El-Nagaar, A.A.A. Zidan, I.M. Al-Sharkawi, C.M. Diaz-Montero and D.J. Cole, 2012. Kinetics of rebounding of lymphoid and myeloid cells in mouse peripheral blood, spleen and bone marrow after treatment with cyclophosphamide. Cell. Immunol., 276: 67-74.
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El-Naggar, S.A., 2012. Impact of a toll-like receptor 3 ligand polyinosinic-cytidylic acid poly(I:C) administration on natural killer cells in absence or presence of peptide vaccination. Egypt. J. Exp. Biol. (Zool.), 8: 25-32.
El-Naggar, S.A., I.M. Al-Sharkawi and G.A. Madkour, 2011. Susceptibility of some wild rodents widely distributed in Egyptian Foci to Schistosoma mansoni infection under laboratory conditions. Int. J. Zool. Res., 7: 358-368.
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El-Naggar, S.A., A.A. El-Brabary, M.A. Mansour, F. Abdel-Shafy and S. Talat, 2011. Anti-tumor activity of some 1,3,4-thiadiazoles and 1,2,4-triazine derivatives against ehrlichs ascites carcinoma. Int. J. Cancer Res., 7: 278-288.
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El-Naggar, S.A., 2011. Lack of the beneficial effects of mirazid (Commiphora molmol) when administered with chemotherapeutic agents on ehrlich ascetic carcinoma bearing mice. Adv. Biol. Res., 5: 193-199.
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Salem, M.L., S.A. El-Naggar and D.J. Cole, 2010. Cyclophosphamide induces bone marrow to yield higher numbers of precursor dendritic cells in vitro capable of functional antigen presentation to T cells in vivo. Cell. Immunol., 261: 134-143.
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Salem, M.L., A.A. Al-Khami, S.A. El-Naggar, C.M. Diaz-Montero and D.J. Cole, 2010. Cyclophosphamide induces dynamic alterations in the host microenvironments resulting in a Flt3 ligand-dependent expansion of dendritic cells. J. Immunol., 184: 1737-1747.
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Salem, M.L., F.Q. Alenzi, N. Nath, S.A. El-Naggar and A.A., Al-Khami et al., 2009. Plasticity of T cell differentiation: A double-edged sword for immune responses. Immunol. Endocrine Metab. Agents Med. Chem. J., 9: 90-105.
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Salem, M.L., C.M. Diaz-Montero, A.A. Al-Khami and S.A. El-Naggar et al., 2009. Recovery from cyclophosphamide-induced lymphopenia results in expansion of immature dendritic cells which can mediate enhanced prime-boost vaccination antitumor responses in vivo when stimulated with the TLR3 agonist poly (I:C). J. Immunol., 182: 2030-2040.
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Salem, M.L., C.M. Diaz-Montero, S.A. El-Naggar, Y. Chen, O. Moussa and D.J. Cole, 2008. TLR3 agonist poly(I:C) targets CD8+ T cells and augments their antigen-specific responses upon their adoptive transfer into naive recipient mice vaccine. Epub., 27: 549-557.
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Diaz-Montero, C.M., S.A. El Naggar, A. Al Khami, R. El Naggar, A.J. Montero, D.J. Cole and M.L. Salem, 2008. Priming of naive CD8+ T cells in the presence of IL-12 selectively enhances the survival of CD8⁺CD62L^hi cells and results in superior anti-tumor activity in a tolerogenic murine model. Cancer Immunol. Immunother., 57: 563-572.
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Salem, M.L., A.N. Kadima, S.A. El-Naggar, M.P. Rubinstein, Y. Chen, W.E. Gillanders and D.J. Cole, 2007. Defining the ability of Cyclophosphamide preconditioning to enhance the antigen-specific CD8+T-cell response to peptide vaccination: Creation of a beneficial host microenvironment involving type I IFNs and myeloid cells. J. Immunother., 30: 40-53.
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Salem, M.L., W.E. Gillanders, A.N. Kadima, S. El-Naggar and M.P. Rubinstein et al., 2006. Novel non-viral delivery approaches for Interleukin-12 protein and gene systems: curbing toxicity and enhancing adjuvant activity. J. Interferon. Cytokine Res., 9: 593-608.
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Salem, M.L., S.A. EL-Naggar, A. Kadima, W.E. Gillanders and D.J. Cole, 2006. The adjuvant effects of the toll-like receptor 3 ligand polyinosinic-cytidylic acid poly (I:C) on antigen-specific CD8+ T cell responses are partially dependent on NK cells and macrophages with the induction of a beneficial cytokine milieu. Vaccine, 24: 5119-5132.
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