Dr. El-Sayed  Mohamed  El-Sayed

Dr. El-Sayed Mohamed El-Sayed

Professor
Faculty of Agriculture, Cairo University, Cairo, Egypt


Highest Degree
Ph.D. in Pharmacology from Al-Azhar University, Cairo, Egypt

Share this Profile

Area of Interest:

Pharmacology and Toxicology
100%
Drug-Lab Interaction
62%
Drug Analysis
90%
Drug Devolepment
75%
Drugs and Diet
55%

Selected Publications

  1. El‐Sayed, E.M., A.E.H. Abd El-Aziz and M.M. Amine, 2018. Nebivolol enhances the effect of alendronate against methylprednisolone-induced osteoporosis in rats. J. Biochem. Mol. Toxicol., (In Press). 10.1002/jbt.22232.
    CrossRef  |  PubMed  |  Direct Link  |  
  2. Elsadek, B., E.M. El-Sayed, A. Mansour and A. Elazab, 2017. Abrogation of carbon tetrachloride-induced hepatotoxicity in sprague-dawley rats by ajwa date fruit extract through ameliorating oxidative stress and apoptosis. Pak. J. Pharm. Sci., 30: 2183-2191.
    Direct Link  |  
  3. El-Sayed, E.M., A.M. Mansour and W.S. El-Sawy, 2017. Protective effect of proanthocyanidins against doxorubicin‐induced nephrotoxicity in rats. J. Biochem. Mol. Toxicol., Vol. 31, No. 11, (In Press). 10.1002/jbt.21965.
    CrossRef  |  PubMed  |  Direct Link  |  
  4. El-Sayed, E.M., A.M. Mansour and M.S. Abdul-Hameed, 2016. Thymol and carvacrol prevent doxorubicin‐induced cardiotoxicity by abrogation of oxidative stress, inflammation, and apoptosis in rats. J. Biochem. Mol. Toxicol., 30: 37-44.
    CrossRef  |  Direct Link  |  
  5. El-Sayed, E.M., A.R. Abdallah, A.M Mansour and A.A. El-Arabey, 2015. Thymol and carvacrol prevent cisplatin‐induced nephrotoxicity by abrogation of oxidative stress, inflammation, and apoptosis in rats. J. Biochem. Mol. Toxicol., 29: 165-172.
    CrossRef  |  Direct Link  |  
  6. El-Sayed, E.M., A.M. Mansour and M.Y. Ghobara, 2015. Abrogation of cisplatin-induced nephrotoxicity in rats by Berne date extract through ameliorating oxidative stress, inflammation and apoptosis. Inter. J. Pharma. Sci. Res., 6: 1226-1233.
    Direct Link  |  
  7. El-Sayed, E.M., A.M. Mansour and M.Y. Ghobara, 2015. Abrogation of cisplatin-induced nephrotoxicity in rats by lycopene through ameliorating oxidative stress, inflammation and apoptosis. Inter. J. Therap. Appl., 27: 16-22.
    Direct Link  |  
  8. El-Sayed, E.M., A.M. Mansour and M.E. Nady, 2015. Protective effects of pterostilbene against acetaminophen‐induced hepatotoxicity in rats. J. Biochem. Mol. Toxicol., 29: 35-42.
    CrossRef  |  Direct Link  |  
  9. El-Raouf, O.M.A., E.M. El-Sayed and M.F. Manie, 2015. Cinnamic acid and cinnamaldehyde ameliorate cisplatin‐induced splenotoxicity in rats. J. Biochem. Mol. Toxicol., 29: 426-429.
    CrossRef  |  Direct Link  |  
  10. E.M. El-Sayed, E.E. Fouda, A.M. Mansour and A.H. Elazab, 2015. Protective effect of lycopene against carbon tetrachloride-induced hepatic damage in rats. Inter. J. Pharma. Sci. Res., 5: 875-881.
    Direct Link  |  
  11. Abdel-Bakky, M.S., G.K. Helal, E.M. El-Sayed and A.S. Saad, 2015. Carbon tetrachloride-induced liver injury in mice is tissue factor dependent. Environ. Toxicol. Pharmacol., 39: 1199-1205.
    CrossRef  |  Direct Link  |  
  12. El-Sayed, E.M., A.M. Mansour and M.E. Nady, 2014. Protective effects of red wine polyphenols and grape-seed proanthocyanidin extract on acetaminophen-induced liver injury. Inter. J. Pharma. Sci. Res., 5: 782-789.
    Direct Link  |  
  13. Abo-Salem, O.M., G.I. Harisa, T.M. Ali, E.S.M. El-Sayed and F.M. Abou-Elnour, 2014. Curcumin ameliorates streptozotocin-induced heart injury in rats. J. Biochem. Mol. Toxicol., 28: 263-270.
    CrossRef  |  Direct Link  |  
  14. Harisa, G.I., O.M. Abo-Salem, M. El-sayed and G. Shazly, 2013. Effects of nutritional and excessive levels of selenium on red blood cells of rats fed a high cholesterol diet. Biol. Trace Elem. Res., 152: 41-49.
    CrossRef  |  Direct Link  |  
  15. El‐Sayed, E.S.M., O.M. Abd El‐Raouf, M. Ola, H.M. Fawzy and M.F. Manie, 2013. Comparative study of the possible protective effects of cinnamic acid and cinnamaldehyde on cisplatin‐induced nephrotoxicity in rats. J. Biochem. Mol. Toxicol., 27: 508-514.
    CrossRef  |  Direct Link  |  
  16. Attia, S.M., S.F. Ahmad, G.I. Harisa, A.M. Mansour, E.M. El Sayed and S.A. Bakheet, 2013. Wogonin attenuates etoposide-induced oxidative DNA damage and apoptosis via suppression of oxidative DNA stress and modulation of OGG1 expression. Food Chem. Toxicol, 59: 724-730.
    CrossRef  |  Direct Link  |  
  17. El-Sayed, E.M., A.H. Abdel-Aziz, S. Saleh and A.S. Saad, 2011. The chemopreventive effect of dimethylthiourea against carmustine-induced myelotoxicity in rats. Food Chem. Toxicol, 49: 1965-1969.
    CrossRef  |  Direct Link  |  
  18. El-Sayed, E.M., A.H. Abdel-Aziz, G.K. Helal, S. Saleh and A.S. Saad, 2010. Protective effect of N-acetylcysteine against carmustine-induced myelotoxicity in rats. Food Chem. Toxicol., 48: 1576-1580.
    CrossRef  |  Direct Link  |  
  19. Abdallah, G.M., E.M. El-Sayed and O.M. Abo-Salem, 2010. Effect of lead toxicity on coenzyme Q levels in rat tissues. Food Chem. Toxicol., 48: 1753-1756.
    CrossRef  |  Direct Link  |  
  20. Harisa, G.E., O.M. Abo-Salem, E.S.M. El-Sayed, E.I. Taha and N. El-Halawany, 2009. L-arginine augments the antioxidant effect of garlic against acetic acid-induced ulcerative colitis in rats. Pak. J. Pharm. Sci., 22: 373-380.
    PubMed  |  
  21. Gutwein, P., M.S. Abdel-Bakky, K. Doberstein, A. Schramme and J. Beckmann et al., 2009. CXCL16 and oxLDL are induced in the onset of diabetic nephropathy. J. Cell. Mol. Med., 13: 3809-3825.
    CrossRef  |  Direct Link  |  
  22. Gutwein, P., M.S. Abdel-Bakky, A. Schramme, K. Doberstein and N. Kampfer-Kolb et al., 2009. CXCL16 is expressed in podocytes and acts as a scavenger receptor for oxidized low-density lipoprotein. Amer. J. Pathol., 174: 2061-2072.
    CrossRef  |  Direct Link  |  
  23. El-Sayed, S.M., O.M. Abo-Salem, H.A. Aly and A.M. Mansour, 2009. Potential antidiabetic and hypolipidemic effects of propolis extract in streptozotocin-induced diabetic rats. Pak. J. Pharm. Sci., 22: 168-174.
    PubMed  |  
  24. Abo-Salem, O.M., E.M. El-Sayed, N. El-Halawany and G.I. Harisa, 2009. Protective effect of garlic against MPTP-induced neurotoxicity in mice. Az. J. Pharm. Sci., 39: 121-130.
  25. El-Sayed, E.S.M., O.M. Abo-Salem, M.F. Abd-Ellah and G.M. Abd-Alla, 2008. Hesperidin, an antioxidant flavonoid, prevents acrylonitrile-induced oxidative stress in rat brain. J. Biochem. Mol. Toxicol., 22: 268-273.
    CrossRef  |  Direct Link  |  
  26. El-Sayed, E.M., M. F. Abd-Ellah and S.M. Attia, 2008. Protective effect of captopril against cisplatin-induced nephrotoxicity in rats. Pak. J. Pharm. Sci., 21: 255-261.
    Direct Link  |  
  27. Attia, S.M., G.K. Helal, M.F. Abd-Ellah, A.M. Mansour and E.M. El-Sayed, 2008. The effects of oral grape seed extract on cisplatin-induced cytogenotoxicity in mice. Saudi Pharm. J., 16: 161-169.
    Direct Link  |  
  28. Soliman, F.M., M.F. Yousif, S.S. Zaghloul, M.M. Okba and E.M. El-Sayed, 2007. Seasonal variation in the essential oil composition of Origanum syriacum L. subsp. sinaicum greuter and burdet; Evaluation of its tocolytic activity. Egypt. J. Biomed. Sci., 23: 121-134.
    CrossRef  |  Direct Link  |  
  29. Omran, G.A. and E.M. El-Sayed, 2007. Comparative effect of single and combined chelation therapy in chronic lead toxicity: Role of reactive oxygen species. Arab. J. Lab. Med., 33: 379-392.
  30. El-Sayed, E.M., 2007. The uterine relaxant effect of curcumin in rats; An in vitro study. J. Egypt. Soc. Toxicol., 36: 101-105.
    Direct Link  |  
  31. El-Shamy, A.M., S. El-Hawary Seham, A. Abdel-Sattar Essam, A.S. Elham, M. El-Sayed El-Sayed and M. Abo-Salem Osama, 2006. Phytochemical studies of cassia glauca lam. family leguminosae; evaluation of the antidiabetic and antioxidant effects of its extracts in rats. Al-Azhar J. Pharm. Sci., 34: 47-62.
  32. Abd-Allah, A.R.A., E.M. El-Sayed, H.A. Mohamed and M.A.H. Farid, 2003. Effect of melatonin on estrogen and progesterone receptors in relation to uterine contraction in rats. Pharmacol. Res., 47: 349-354.
    CrossRef  |  Direct Link  |  
  33. Osman, A.M., E.M. El-Sayed, E. El-Demerdash, A. Al-Hyder, M. El-Didi, A.S. Attia and F.M.A. Hamada, 2000. Prevention of cisplatin-induced nephrotoxicity by methimazole. Pharmacol. Res., 41: 115-121.
    CrossRef  |  Direct Link  |  
  34. Moustafa, A.M., E.M. El-Sayed, O.A. Badary, A.M. Mansour and F.M.A. Hamada, 1999. Effect of bromocriptine on uterine contractility in near-term pregnant rats. Pharmacol. Res., 39: 89-95.
    CrossRef  |  Direct Link  |  
  35. Ramadan, L.A., A.M.A. Moustafa and E.M. El-Sayed, 1997. A possible protecting activity of diltiazem against irradiation hazards on the cardiac muscle. Az. J. Pharm. Sci., 19: 1-8.
  36. Morad, F., E.M. El-Sayed and S.M. Mahmoud, 1997. Inhibition of steroid sex hormones release in rats by two ca2+ channel blockers. Pharmacol. Res., 35: 177-180.
    CrossRef  |  Direct Link  |  
  37. El-Sayed, E.M., L.A. Ramadan, A.H.A. Abdel, A.M. Moustafa and F.M.A. Hamada, 1996. The effect of Thiola, Piroxicam and Diltiazem on the uterine contractility of γ-irradiated rats. Pharmacol. Res., 34: 231-236.
    CrossRef  |  Direct Link  |  
  38. Badary, O.A., A.M. Agha, E.M. El-Sayed and F.M.A. Hamada, 1996. Altered uterine sensitivity to oxytocin and prostaglandin fin dimethylbenz(a)anthracene (dmba)-induced rat mammary carcinoma: the effects of tamoxifen and/or recombinant human interferon α2b therapy. Pharmacol. Res., 34: 99-103.
    CrossRef  |  Direct Link  |  
  39. Hamada, F.M.A., A.H.A. Abdel, W.A. Anwar, E.M. El-Sayed and M.A. El-Mahdy, 1993. The potential genotoxic effect of gemfibrozil on somatic and germ cells of male mice. Az. J. Pharm. Sci., 12: 85-104.
  40. Hamada, F.M.A., I.A. Mahmoud, M.M.A. El-Mazar, A.H. Abdel Aziz and E.M. El-Sayed, 1989. In-vitro and in-vivo study on the response of non-pregnent and pregnant rat uterus to uterine stimulants in experimentally-induced renal hypertension. J. Egypt. Soc. Pharmacol. Exp. Ther., 8: 369-399.