Dr. Nadia M. Hamdy ElHefny
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Dr. Nadia M. Hamdy ElHefny

Professor
Department of Biochemistry, Faculty of Pharmacy, Ain Shams University, Egypt


Highest Degree
Ph.D. in Biochemistry from Ain Shams University, Cairo, Egypt

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Area of Interest:

Biomedical Sciences
100%
Molecular Oncology
62%
Bionanotechnology
90%
Epigenetics
75%
Cancer Bioinformatics
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
68
Abstracts
0

Selected Publications

  1. Eldosoky, M.A., R. Hammad, A.A. Elmadbouly, R.B. Aglan and S.G. AbdelHamid et al., 2023. Diagnostic significance of hsa-miR-21-5p, hsa-miR-192-5p, hsa-miR-155-5p, hsa-miR-199a-5p panel and ratios in hepatocellular carcinoma on top of liver cirrhosis in HCV infected patients. Int. J. Mol. Sci., Vol. 24. 10.20944/preprints202211.0462.v1.
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  2. Eldosoky, M.A., R. Hammad, A.A. Elmadbouly, R.B. Aglan and S.G. Abdel-Hamid et al., 2023. Diagnostic significance of hsa-miR-21-5p, hsa-miR-192-5p, hsa-miR-155-5p, hsa-miR-199a-5p panel and ratios in hepatocellular carcinoma on top of liver cirrhosis in HCV-infected patients. Int. J. Mol. Sci., Vol. 24. 10.3390/ijms24043157.
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  3. Rizk, N.I., A.I. Abulsoud, M.M. Kamal, D.H. Kassem and N.M. Hamdy, 2022. Exosomal-long non-coding RNAs journey in colorectal cancer: Evil and goodness faces of key players. Life Sci., Vol. 292. 10.1016/j.lfs.2022.120325.
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  4. Hammad, R., R.B. Aglan, S.A. Mohammed, E.A.E. Awad and M.A. Elsaid et al., 2022. Cytotoxic T cell expression of leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) in viral hepatitis c-mediated hepatocellular carcinoma. Int. J. Mol. Sci., Vol. 23. 10.3390/ijms232012541 .
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  5. Hamdy, N.M., Y. Jiang, S. Sahni, W. Wu, Y. Zhang, B. Sirohi and J. Chen, 2022. Editorial: Women in hepato pancreatic biliary (HPB) tumors: 2021, Volume I. Front. Oncol., Vol. 12. 10.3389/fonc.2022.927775.
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  6. Hamdy, N.M., G. Eskander and E.B. Basalious, 2022. Insights on the dynamic innovative tumor targeted-nanoparticles-based drug delivery systems activation techniques. Int. J. Nanomed., 17: 6131-6155.
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  7. Hamdy, N.M., A.A. Boseila, A. Ramadan and E.B. Basalious, 2022. Iron oxide nanoparticles-plant insignia synthesis with favorable biomedical activities and less toxicity, in the “Era of the-Green”: A systematic review. Pharmaceutics, Vol. 14. 10.3390/pharmaceutics14040844.
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  8. Emam, O., E.F. Wasfey and N.M. Hamdy, 2022. Notch-associated lncRNAs profiling circuiting epigenetic modification in colorectal cancer. Cancer Cell Int., Vol. 22. 10.1186/s12935-022-02736-2.
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  9. Eldeeb, M., E. F. Sanad, A. Ragab, Y. A. Ammar, K. Mahmoud, M.M. Ali and N.M. Hamdy, 2022. Anticancer effects with molecular docking confirmation of newly synthesized isatin sulfonamide molecular hybrid derivatives against hepatic cancer cell lines. Biomedicines, Vol. 10. 10.3390/biomedicines10030722.
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  10. El-Sheikh, N.M., A.I. Abulsoud, E.F. Wasfey and N.M. Hamdy, 2022. Insights on the potential oncogenic impact of long non-coding RNA nicotinamide nucleotide transhydrogenase antisense RNA 1 in different cancer types, integrating pathway(s) and clinical outcome(s) association. Pathol. Res. Pract., Vol. 240. 10.1016/j.prp.2022.154183.
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  11. El-Sheikh, N., A. Abulsoud, E.F. Wasfey and N.M. Hamdy, 2022. Evolutionary insights on the potential oncogenic impact of long non-coding RNA NNT-AS1 in different types of carcinomas; integrating pathway(s) and clinical outcomes association. Res. Square, 10.21203/rs.3.rs-1682128/v1.
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  12. Bhattacharya, K., I.M. Shamkh, M.S. Khan, M.M. Lotfy and J.B. Nzeyimana et al., 2022. Multi-epitope vaccine design against monkeypox virus via reverse vaccinology method exploiting immunoinformatic and bioinformatic approaches. Vaccines, Vol. 10. 10.3390/vaccines10122010 .
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  13. Anwar, M.M., C. Albanese, N.M. Hamdy and A.S. Sultan, 2022. Rise of the natural red pigment 'prodigiosin' as an immunomodulator in cancer. Cancer Cell Int., Vol. 22. 10.1186/s12935-022-02815-4.
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  14. Abd El Fattah, Y.K., A.I. Abulsoud, S.G. AbdelHamid and N.M. Hamdy, 2022. Interactome battling of lncRNA CCDC144NL-AS1: Its role in the emergence and ferocity of cancer and beyond. Int. J. Biol. Macromol., 222: 1676-1687.
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  15. Hamdy, N.M., F.H. Shaker, X. Zhan and E.B. Basalious, 2022. Tangled quest of post-COVID-19 infection-caused neuropathology and what 3P nano-bio-medicine can solve? EPMA J., 13: 261-284.
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  16. Salama, S., N. Hamdy, R. El-Shemy and H. El-Mesallamy, 2021. Clinical significance of the transcription factor SOX11, cell-cell adhesion protein e-cadherin and zinc finger protein bcl11a in the diagnosis of breast cancer. Arch. Pharm. Sci. Ain Shams Univ., 5: 97-110.
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  17. Mahmoud, M.M., E.F. Sanad, R.A.A. Elshimy and N.M. Hamdy, 2021. Competitive endogenous role of the LINC00511/miR-185-3p Axis and miR-301a-3p from liquid biopsy as molecular markers for breast cancer diagnosis. Front. Oncol., Vol. 11. 10.3389/fonc.2021.749753.
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  18. Mahmoud, M.M., E.F. Sanad and N.M. Hamdy, 2021. MicroRNAs’ role in the environment-related non-communicable diseases and link to multidrug resistance, regulation, or alteration. Environ. Sci. Pollut. Res., 28: 36984-37000.
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  19. Hamdy, N., 2021. Biochemical oncology for personalized and precision medicine. Int. J. Cancer Biomed. Res., Vol. 5. 10.21608/JCBR.2021.69602.1192.
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  20. Ali, N.A., N.M. Hamdy, A.A. Gibriel and H.O. EL Mesallamy, 2021. Investigation of the relationship between CTLA4 and the tumor suppressor RASSF1A and the possible mediating role of STAT4 in a cohort of Egyptian patients infected with hepatitis C virus with and without hepatocellular carcinoma. Arch. Virol., 166: 1643-1651.
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  21. AbdelHamid, S.G., A.A. Refaat, A.M. Benjamin, L.A. Elmawardy and L.A. Elgendy et al., 2021. Deciphering epigenetic(s) role in modulating susceptibility to and severity of COVID-19 infection and/or outcome: A systematic rapid review. Environ. Sci. Pollut. Res., 28: 54209-54221.
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  22. Hamdy, N.M. and R.A. El-Shemy, 2020. Molecular profiling of breast cancer susceptibility of obese or insulin-resistant and pre-diabetic patients using ITLN1 and CD295 SNPs. medRxiv, 10.1101/2020.01.08.20016980.
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  23. Abo-Zeid, Y., N.S.M. Ismail, G.R. McLean and N.M. Hamdy, 2020. A molecular docking study repurposes FDA approved iron oxide nanoparticles to treat and control COVID-19 infection. Eur. J. Pharm. Sci., Vol. 153. 10.1016/j.ejps.2020.105465.
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  24. Tamim, D.A., N.M. Hamdy, M.M. Kamal and A.S. Nada, 2019. Gonadotropin-releasing hormone antagonist protects against ɣ-radiation-induced female infertility in rats. J. Nucl. Technol. Appl. Sci., 7: 1-8.
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  25. Wasfey, E., R. Abd El-Razik, N. Hamdy, W. El-Kilany and H. El-Mesallamy, 2018. Alteration of metabolic genes in peripheral blood isolated from patients with acute myocardial infarction. Arch. Pharm. Sci. Ain Shams Univ., 2: 16-21.
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  26. El-Mesallamy, H.O., H.M. El Magdoub, J.M. Chapman, N.M. Hamdy, M.F. Schaalan, L.N. Hammad and S.H. Berger, 2018. Biomolecular study of human thymidylate synthase conformer-selective inhibitors: New chemotherapeutic approach. PLoS ONE, Vol. 13. 10.1371/journal.pone.0193810.
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  27. Youssef, S.S. and N.M. Hamdy, 2017. SOCS1 and pattern recognition receptors: TLR9 and RIG-I; novel haplotype associations in Egyptian fibrotic/cirrhotic patients with HCV genotype 4. Arch. Virol., 162: 3347-3354.
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  28. Sanad, E.F., N.M. Hamdy A.K. El-Etriby, S.A. Sebak and H.O. El-Mesallamy, 2017. Peripheral leucocytes and tissue gene expression of granzyme B/perforin system and serpinB9: Impact on inflammation and insulin resistance in coronary atherosclerosis. Diabetes Res. Clin. Pract., 131: 132-141.
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  29. Khella, M.S., N.M. Hamdy, A.I. Amin and H.O. El-Mesallamy, 2017. The (FTO) gene polymorphism is associated with metabolic syndrome risk in Egyptian females: A case-control study. BMC Med. Genet., Vol. 18. 10.1186/s12881-017-0461-0.
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  30. Rizk, H.H., N.M. Hamdy, N.L. Al-Ansari and H.O. El-Mesallamy, 2016. Pretreatment predictors of response to PegIFN-RBV therapy in Egyptian patients with HCV genotype 4. PLoS ONE, Vol. 11. 10.1371/journal.pone.0153895.
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  31. Radwan, S.M., N.M. Hamdy, H.M. Hegab and H.O. El-Mesallamy, 2016. Beclin-1 and hypoxia-inducible factor-1α genes expression: Potential biomarkers in acute leukemia patients. Cancer Biomarkers, 16: 619-626.
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  32. Mostafa, A.M., N.M. Hamdy, S.Z. Abdel-Rahman and H.O. El-Mesallamy, 2016. Effect of vildagliptin and pravastatin combination on cholesterol efflux in adipocytes. IUBMB Life, 68: 535-543.
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  33. Khalil, B.M., M.H. Shahin, M.H.M. Solayman, T. Langaee and M.F. Schaalan et al., 2016. Genetic and nongenetic factors affecting clopidogrel response in the Egyptian population. Clin. Transl. Sci., 9: 23-28.
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  34. Kamal, A.M., N.M. Hamdy, H.M. Hegab and H.O. El-Mesallamy, 2016. Expression of thioredoxin-1 (TXN) and its relation with oxidative DNA damage and treatment outcome in adult AML and ALL: A comparative study. Hematology, 21: 567-575.
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  35. El-Derany, M.O., N.M. Hamdy, N.L. Al-Ansari and H. O. El-Mesallamy, 2016. Integrative role of vitamin D related and Interleukin-28B genes polymorphism in predicting treatment outcomes of chronic hepatitis C. BMC Gastroenterol., Vol. 16. 10.1186/s12876-016-0440-5.
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  36. Mostafa, A.M., N.M. Hamdy, H.O. El-Mesallamy and S.Z. Abdel-Rahman, 2015. Glucagon-like peptide 1 (GLP-1)-based therapy upregulates LXR-ABCA1/ABCG1 cascade in adipocytes. Biochem. Biophys. Res. Commun., 468: 900-905.
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  37. Aboouf, M.A., N.M. Hamdy, A.I. Amin and H.O. El-Mesallamy, 2015. Genotype screening of APLN rs3115757 variant in Egyptian women population reveals an association with obesity and insulin resistance. Diabetes Res. Clin. Pract., 109: 40-47.
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  38. Khella, M.S., N.M. Hamdy, A.I. Amin and H.O. El-Mesallamy, 2014. The role of fat mass and obesity-associated gene polymorphism in obese Egyptians. Al-Azhar J. Pharm. Sci., 50: 173-180.
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  39. El-Mesallamy, H.O., N.M. Hamdy, Y.A. Ibrahim, A.K. Al-Etriby and E.F. Sanad, 2014. Impact of granzyme b gene expression on inflammation and insulin resistance in atherosclerosis. Al-Azhar J. Pharm. Sci., 49: 155-167.
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  40. El-Mesallamy, H.O., M.R. Diab, N.M. Hamdy and S.M. Dardir, 2014. Cell-based regenerative strategies for treatment of diabetic skin wounds, a comparative study between human umbilical cord blood-mononuclear cells and calves' blood haemodialysate. PLoS ONE, Vol. 9. 10.1371/journal.pone.0089853.
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  41. El Mesallamy, H.O., W.M. Rashed, N.M. Hamdy and N. Hamdy, 2014. High-dose methotrexate in Egyptian pediatric acute lymphoblastic leukemia: The impact of ABCG2 C421A genetic polymorphism on plasma levels, what is next? J. Cancer Res. Clin. Oncol., 140: 1359-1365.
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  42. El Mesallamy, H.O., N.M. Hamdy, D.M. Mostafa and A.I. Amin, 2014. The serine protease granzyme B as an inflammatory marker, in relation to the insulin receptor cleavage in human obesity and type 2 diabetes mellitus. J. Interferon Cytokine Res., 34: 179-186.
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  43. El-Mesallamy, H.O., N.M. Hamdy, A.S. Zaghloul and A.M. Sallam, 2013. Clinical value of circulating lipocalins and insulin-like growth factor axis in pancreatic cancer diagnosis. Pancreas, 42: 149-154.
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  44. El-Mesallamy, H.O., N.M. Hamdy, A.K. El-Etriby and E.F. Wasfey, 2013. Plasma granzyme B in ST elevation myocardial infarction versus non-ST elevation acute coronary syndrome: Comparisons with IL-18 and fractalkine. Mediators Inflammation, Vol. 2013. 10.1155/2013/343268.
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  45. El-Mesallamy, H.O., N.M. Hamdy and A.A.M. Sallam, 2013. Effect of obesity and glycemic control on serum lipocalins and insulin-like growth factor axis in type 2 diabetic patients. Acta Diabetol., 50: 679-685.
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  46. Swellam, M. and N.M. Hamdy, 2012. Association of nonalcoholic fatty liver disease with a single nucleotide polymorphism on the gene encoding leptin receptor. IUBMB Life, 64: 180-186.
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  47. Hamdy, N.M., F.A. Al-Abbasi, H.A. Alghamdi, M.F. Tolba, A. Esmat and A.B. Abdel-Naim, 2012. Role of neutrophils in acrylonitrile-induced gastric mucosal damage. Toxicol. Lett., 208: 108-114.
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  48. Hamdy, N.M. and E. El-Demerdash, 2012. New therapeutic aspect for carvedilol: Antifibrotic effects of carvedilol in chronic carbon tetrachloride-induced liver damage. Toxicol. Appl. Pharmacol., 261: 292-299.
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  49. Ella, D., K. Saleh, M. Hassan, N. Hamdy, M. El-Araby and K.A. Abouzid, 2012. Synthesis and anti-proliferative activity of substituted-anilinoquinazolines and its relation to EGFR inhibition. Arzneimittelforschung, 62: 360-366.
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  50. El-Mesallamy, H.O., N.M. Hamdy, T.M. Salman and S.M. Ibrahim, 2012. Adiponectin and sE-selectin concentrations in relation to inflammation in obese type 2 diabetic patients with coronary heart disease. Angiology, 63: 96-102.
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  51. El-Mesallamy, H.O., N.M. Hamdy, A.S. Zaghloul and A.M. Sallam, 2012. Serum retinol binding protein-4 and neutrophil gelatinase-associated lipocalin are interrelated in pancreatic cancer patients. Scand. J. Clin. Lab. Invest., 72: 602-607.
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  52. Hamdy, N.M., 2011. Relationship between pro-anti-inflammatory cytokines, T-cell activation and CA 125 in obese patients with heart failure. Med. Sci. Monit., 17: CR173-CR178.
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  53. El-Mesallamy, H.O., N.M. Hamdy, O.A. Ezzat and A.M. Reda, 2011. Levels of soluble advanced glycation end product-receptors and other soluble serum markers as indicators of diabetic neuropathy in the foot. J.Invest. Med., 59: 1233-1238.
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  54. El-Mesallamy, H.O., N.M. Hamdy, H.H. Rizk and A.R. El-Zayadi, 2011. Apelin serum level in Egyptian patients with chronic hepatitis C. Mediators Inflammation, Vol. 2011. 10.1155/2011/703031.
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  55. El-Mesallamy, H.O., M.O. El-Derany and N.M. Hamdy, 2011. Serum omentin-1 and chemerin levels are interrelated in patients with Type 2 diabetes mellitus with or without ischaemic heart disease. Diabetic Med., 28: 1194-1200.
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  56. Chakraborti, S., K.L. Barik, A.K. Singh, S.S. Nag and P.A Amira et al., 2011. Adiponectin and pro-inflammatory cytokines in obese diabetic boys. Indian Pediatr., 48: 811-819.
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  57. El Mesallamy, H., N. Hamdy, S. Suwailem and S. Mostafa, 2010. Oxidative stress and platelet activation: Markers of myocardial infarction in type 2 diabetes mellitus. Angiology, 61: 14-18.
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  58. Hamdy, N.M., S.M. Suwailem and H.O. El-Mesallamy, 2009. Influence of vitamin E supplementation on endothelial complications in type 2 diabetes mellitus patients who underwent coronary artery bypass graft. J. Diabetes Complic., 23: 167-173.
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  59. Hamdy, N.M. and A. Taha, 2009. Effects of Nigella sativa oil and thymoquinone on oxidative stress and neuropathy in streptozotocin-induced diabetic rats. Pharmacology, 84: 127-134.
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  60. El-Mesallamy, H., S. Suwailem and N. Hamdy, 2007. Evaluation of C-reactive protein, endothelin-1, adhesion molecule(s), and lipids as inflammatory markers in type 2 diabetes mellitus patients. Mediators Inflammation, Vol. 2007. 10.1155/2007/73635.
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