Dr. Essam Ahmed Ghazaly Kerwash
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Dr. Essam Ahmed Ghazaly Kerwash

Leading Senior Clinical Pharmacology Assessor
Medicines and Healthcare products Regulatory Agency (MHRA), London, UK


Highest Degree
Ph.D. in Clinical Pharmacology from University of London, United Kingdom

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Area of Interest:

Biomedical Sciences
100%
Cancer Biology
62%
Cancer Immunology
90%
Metabolism
75%
Oncology
55%

Research Publications in Numbers

Books
8
Chapters
0
Articles
38
Abstracts
50

Selected Publications

  1. Coppola, P., E. Kerwash and S. Cole, 2023. Use of physiologically based pharmacokinetic modeling for hepatically cleared drugs in pregnancy: Regulatory perspective. J. Clin. Pharmacol., 63: S62-S80.
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  2. Coppola, P., A. Butler, S. Cole and E. Kerwash, 2023. Total and free blood and plasma concentration changes in pregnancy for medicines highly bound to plasma proteins: Application of physiologically based pharmacokinetic modelling to understand the impact on efficacy. Pharmaceutics, Vol. 15. 10.3390/pharmaceutics15102455.
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  3. Serpi, M., V. Ferrari, C. McGuigan, E. Ghazaly and C. Pepper, 2022. Synthesis and characterization of NUC-7738, an aryloxy phosphoramidate of 3′-deoxyadenosine, as a potential anticancer agent. J. Med. Chem., 65: 15789-15804.
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  4. Coppola, P., E. Kerwash, J. Nooney, A. Omran and S. Cole, 2022. Pharmacokinetic data in pregnancy: A review of available literature data and important considerations in collecting clinical data. Front. Med., Vol. 9. 10.3389/fmed.2022.940644.
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  5. Coppola, P., E. Kerwash and S. Cole, 2022. The use of pregnancy physiologically based pharmacokinetic modeling for renally cleared drugs. J. Clin. Pharmacol., 62: S129-S139.
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  6. Slusarczyk, M., M. Serpi, E. Ghazaly, B.M. Kariuki, C. McGuigan and C. Pepper, 2021. Single diastereomers of the clinical anticancer ProTide agents NUC-1031 and NUC-3373 preferentially target cancer stem cells in vitro. J. Med. Chem., 64: 8179-8193.
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  7. Marshall, A., J. Kasturiarachchi, P. Datta, Y. Guo and E. Deltcheva et al., 2021. Author correction: Mir142 loss unlocks IDH2R140-dependent leukemogenesis through antagonistic regulation of HOX genes. Sci. Rep., Vol. 11. 10.1038/s41598-021-84578-y.
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  8. Kazmi, F., S. Nicum, R.L. Roux, L. Spiers and C. Gnanaranjan et al., 2021. A phase Ib open-label, dose-escalation study of NUC-1031 in combination with carboplatin for recurrent ovarian cancer. Clin. Cancer Res., 27: 3028-3038.
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  9. Coppola, P., E. Kerwash and S. Cole, 2021. Physiologically based pharmacokinetics model in pregnancy: A regulatory perspective on model evaluation. Front. Pediatr., Vol. 9. 10.3389/fped.2021.687978.
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  10. Vrettos, E.I., I.E. Valverde, A. Mascarin, P.N. Pallier and L. Cerofolini et al., 2020. Single peptide backbone surrogate mutations to regulate angiotensin GPCR subtype selectivity. Chem. A Eur. J., 26: 10690-10694.
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  11. Marshall, A., J. Kasturiarachchi, P. Datta, Y. Guo and E. Deltcheva et al., 2020. Mir142 loss unlocks IDH2R140-dependent leukemogenesis through antagonistic regulation of HOX genes. Sci. Rep., Vol. 10. 10.1038/s41598-020-76218-8.
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  12. Hay, J.L., J. O'Sullivan, E. Kerwash, A.R. Ilie and S.M. Cole, 2020. A review of clinical pharmacology deficiencies of European centralised drug marketing authorisation applications. Regul. Toxicol. Pharmacol., Vol. 118. 10.1016/j.yrtph.2020.104804.
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  13. Ghazaly, E.A., F. Miraki-Moud, P. Smith, C. Gnanaranjan and L. Koniali et al., 2020. Repression of sphingosine kinase (SK)-interacting protein (SKIP) in acute myeloid leukemia diminishes SK activity and its re-expression restores SK function. J. Biol. Chem., 295: 5496-5508.
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  14. Cole, S., P. Coppola, E. Kerwash, J. Nooney and S.P. Lam, 2020. Pharmacokinetic characterization to enable medicine use in pregnancy, the potential role of physiologically-based pharmacokinetic modeling: A regulatory perspective. CPT Pharmacometrics Syst. Pharmacol., 9: 547-549.
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  15. Cole, S., E. Kerwash and A. Andersson, 2020. A summary of the current drug interaction guidance from the European Medicines Agency and considerations of future updates. Drug Metab. Pharmacokinet., 35: 2-11.
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  16. Ali, S., R. Kjeken, C. Niederlaender, G. Markey and T.S. Saunders et al., 2020. The European medicines agency review of Kymriah (Tisagenlecleucel) for the treatment of acute lymphoblastic leukemia and diffuse large B-cell lymphoma. Oncologist, 25: e321-e327.
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