Dr. Sofiane  Bezzine
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Dr. Sofiane Bezzine

Professor
Higher Institute of Biotechnology of Sfax, Tunisia


Highest Degree
Ph.D. in Nutrition from University of Aix-Marseille III, France

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Area of Interest:

Chemistry
100%
Biological Chemistry
62%
Biochemistry
90%
Medicinal Chemistry
75%
Chromatography
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
0
Abstracts
0

Selected Publications

  1. Zouari-Kessentini, R., J. Luis, A. Karray, O. Kallech-Ziri and N. Srairi-Abid et al., 2009. Two purified and characterized phospholipases A2 from Cerastes cerastes venom, that inhibit cancerous cell adhesion and migration. Toxicon, 53: 444-453.
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  2. Karray, A., A. Ben Bacha, F. Frikha, Y. Gargouri and S. Bezzine, 2009. Biochemical and molecular characterization of purified chicken pancreatic phospholipase A2. FEBS J., 276: 4545-4554.
    CrossRef  |  Direct Link  |  
  3. Ghribi, D., A. Sayari, Y. Gargouri and S. Bezzine, 2009. Improvement of Staphylococcus xylosus lipase production through optimization of the culture conditions. J. Lipid Sci. Technol., 111: 967-971.
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  4. Kammoun, M., Y. Gargouri and S. Bezzine, 2008. Purification and characterization of the first reptile pancreatic lipase: The turtle. Pancreas, 36: 302-308.
    CrossRef  |  PubMed  |  
  5. Touaibia, M., A. Djimde, F. Cao, E. Boilard and S. Bezzine et al., 2007. Inhibition of secreted phospholipase A2. 4-Glycerol derivatives of 4,5-dihydro-3-(4-tetradecyloxybenzyl)-1,2,4-4h-oxadiazol-5-one with broad activities. J. Med. Chem., 50: 1618-1626.
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  6. Rouault, M., C. Le Calvez, E. Boilard, F. Surrel and A. Singer et al., 2007. Recombinant production and properties of binding of the full set of mouse secreted phospholipases A2 to the mouse M-type receptor. Biochemistry, 46: 1647-1662.
    CrossRef  |  Direct Link  |  
  7. Bacha, A.B., Y. Gargouri, S. Bezzine, H. Mosbah and H. Mejdoub, 2007. Ostrich pancreatic phospholipase A2: Purification and biochemical characterization. J. Chromatogr. B, 857: 108-114.
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  8. Muller, P., G. Lena, E. Boilard, S. Bezzine, G. Lambeau, G. Guichard and D. Rognan, 2006. In silico-guided target identification of a scaffold-focused library:  1,3,5-triazepan-2,6-diones as novel phospholipase A2 inhibitors. J. Med. Chem., 49: 6768-6778.
    CrossRef  |  Direct Link  |  
  9. Mosbah, H., A. Sayari, S. Bezzine and Y. Gargouri, 2006. Expression, purification and characterization of His-tagged Staphylococcus xylosus lipase wild-type and its mutant Asp 290 Ala. Protein Expression Purif., 47: 516-523.
    CrossRef  |  Direct Link  |  
  10. Karra-Chaabouni, M., H. Ghamgui, S. Bezzine, A. Rekik and Y. Gargouri, 2006. Production of flavour esters by immobilized Staphylococcus simulans lipase in a solvent-free system. Process Biochem., 41: 1692-1698.
    CrossRef  |  
  11. Boilard, E., M. Rouault, F. Surrel, C. Le Calvez and S. Bezzine et al., 2006. Secreted phospholipase A2 inhibitors are also potent blockers of binding to the M-type receptor. Biochemistry, 45: 13203-13218.
    CrossRef  |  Direct Link  |  
  12. Bacha, A.B., Y. Gargouri, S. Bezzine and H. Mejdoub, 2006. Purification and biochemical characterization of phospholipase A2 from dromedary pancreas. Biochimica et Biophysica Acta (BBA)-Gen. Subj., 1760: 1202-1209.
    CrossRef  |  Direct Link  |  
  13. Granata, F., A. Petraroli, E. Boilard, S. Bezzine and J. Bollinger et al., 2005. Activation of cytokine production by secreted phospholipase A2 in human lung macrophages expressing the M-type receptor. J. Immunol., 174: 464-474.
    Direct Link  |  
  14. Perrin-Cocon, L., S. Agaugue, F. Coutant, A. Masurel and S. Bezzine et al., 2004. Secretory phospholipase A2 induces dendritic cell maturation. Eur. J. Immunol., 34: 2293-2302.
    CrossRef  |  Direct Link  |  
  15. Murakami, M., S. Masuda, S. Shimbara, S. Bezzine and M. Lazdunski et al., 2003. Cellular arachidonate-releasing function of novel classes of secretory phospholipase A2s (Groups III and XII). J. Biol. Chem., 278: 10657-10667.
    CrossRef  |  
  16. Singer, A.G., F. Ghomashchi, C. Le Calvez, J. Bollinger and S. Bezzine et al., 2002. Interfacial kinetic and binding properties of the complete set of human and mouse groups I, II, V, X and XII secreted phospholipases A2. J. Biol. Chem., 277: 48535-48549.
    CrossRef  |  Direct Link  |  
  17. Chahinian, H., S. Bezzine, F. Ferrato, M. G. Ivanova, B. Perez, M.E. Lowe and F. Carriere, 2002. The β5'loop of the pancreatic lipase C2-like domain plays a critical role in the lipase-lipid interactions. Biochemistry, 41: 13725-13735.
    CrossRef  |  Direct Link  |  
  18. Bezzine, S., J. Bollinger, A.G. Singer, S.L. Veatch, S.L. Keller and M.H. Gelb, 2002. On the binding preference of human groups IIA and X phospholipases A2 for membranes with anionic phospholipids. J. Biol. Chem., 277: 48523-48534.
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  19. Bezzine, S., R.S. Koduri, E. Valentin, M. Murakami and I. Kudo et al., 2000. Exogenously added human group X secreted phospholipase A2 but not the group IB, IIA and V enzymes efficiently release arachidonic acid from adherent mammalian cells. J. Biol. Chem., 275: 3179-3191.
    CrossRef  |  Direct Link  |  
  20. Bezzine, S., H. Chahinian, R. Verger and F. Carriere, 2000. The Lid Domain of Human Pancreatic Lipase is not Essential for Interfacial Binding and Functional Lipase-Colipase Interactions. In: Lipases and Lipids: Structure, Function and Biotechnological Applications, Kokotos, G. and V. Constantinou-Kokotou (Eds.). Crete University Press, Rethimno, Greece, pp: 41-57.
  21. Van Tilbeurgh, H., S. Bezzine, C. Cambillau, R. Verger and F. Carriere, 1999. Colipase: Structure and interaction with pancreatic lipase. Biochimica et Biophysica Acta (BBA)-Mol. Cell Biol. Lipids, 1441: 173-184.
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  22. De Caro, A., S. Bezzine, V. Lopez, M. Aoubala, C. Daniel, R. Verger and F. Carriere, 1999. Immunological Characterization of Digestive Lipases. In: Lipase and Phospholipase Protocols (Methods in Molecular Biology), Doolittle, M. and K. Reue (Eds.). Chapter 22, Humana Press, Totowa, NJ., USA., ISBN-13: 9780896035461, pp: 239-256.
  23. Bezzine, S., F. Ferrato, V. Lopez, A. de Caro, R. Verger and F. Carriere, 1999. One-Step Purification and Biochemical Characterization of Recombinant Pancreatic Lipases Expressed in Insect Cells. In: Lipase and Phospholipase Protocols (Methods in Molecular Biology), Doolittle, M. and K. Reue (Eds.). Chapter 19, Humana Press, Totowa, NJ., USA., ISBN-13: 9780896035461, pp: 187-202.
  24. Bezzine, S., F. Ferrato, M.G. Ivanova, V. Lopez, R. Verger and F. Carriere, 1999. Human pancreatic lipase: Colipase dependence and interfacial binding of lid domain mutants. Biochemistry, 38: 5499-5510.
    CrossRef  |  Direct Link  |  
  25. Roussel, A., J. de Caro, S. Bezzine, L. Gastinel and A. de Caro et al., 1998. Reactivation of the totally inactive pancreatic lipase RP1 by structure-predicted point mutations. Proteins: Struct. Funct. Genet., 32: 523-531.
    CrossRef  |  Direct Link  |  
  26. Bezzine, S., F. Carriere, J. de Caro, R. Verger and A. de Caro, 1998. Human pancreatic lipase: An exposed hydrophobic loop from the C-terminal domain may contribute to interfacial binding. Biochemistry, 37: 11846-11855.
    CrossRef  |  Direct Link  |  
  27. Bezzine, S., A. Roussel, J. de Caro, L. Gastinel and A. de Caro et al., 1998. An inactive pancreatic-related protein is activated into a triglyceride-lipase by mutagenesis based on the 3-D structure. Chem. Phys. Lipids, 93: 103-114.
    CrossRef  |  Direct Link  |  
  28. Carriere, F., S. Bezzine and R. Verger, 1997. Molecular evolution of the pancreatic lipase and two related enzymes towards different substrate selectivities. J. Mol. Catal. B: Enzymatic, 3: 55-64.
    CrossRef  |  Direct Link  |  
  29. Aoubala, M., I. Douchet, S. Bezzine, M. Hirn, R. Verger and A. de Caro, 1997. Immunological Techniques for the Characterization of Digestive Lipases. In: Methods in Enzymology, Volume 286: Lipases, Part B: Enzyme Characterization and Utilization, Rubin, B. and E.A. Dennis (Eds.). Chapter 7, Academic Press, New York, USA., ISBN-13: 9780121821876, pp: 126-149.