Dr. Paul  Chidoka Chikezie

Dr. Paul Chidoka Chikezie

Professor
Imo State University, Nigeria


Highest Degree
Ph.D. in Medical Biochemistry from University of Port Harcourt, Nigeria

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Biography

PROFESSOR PAUL C. CHIKEZIE is a Research Scientist/Lecturer and, presently, the Head of Department (HOD) of Biochemistry, Imo State University, Owerri, Nigeria. PROFESSOR PAUL C. CHIKEZIE holds a Bachelor of Science (B.Sc.) degree in Biochemistry, Masters of Science (M.Sc.) degree in Medical Biochemistry/Immunochemistry and Doctor of Philosophy (Ph.D.) degree in Medical Biochemistry, as well as Certificate in Advanced Digital Appreciation. PROFESSOR PAUL C. CHIKEZIE has over twenty (20) years of research and cognitive experience in the academia with one hundred and sixteen (116) scholarly publications, which include scientific articles in reputable international and local learned journals, as well as edited books and book chapter contributions. PROFESSOR PAUL C. CHIKEZIE’s research interests encompass clinical enzymology/toxicology, oxidative stress, phytomedicine, food chemistry/nutritional biochemistry, polyphenol oxidases and haemoglobinopathies with emphasis on sickle cell anaemias.

Area of Interest:

Pharmacology and Toxicology
100%
Oxidative Stress
62%
Hyperlipidemia
90%
Hyperglycemia
75%
Molecular Biology Techniques
55%

Selected Publications

  1. Ohiagu, F.O., P.C. Chikezie, C.M. Chikezie and C.E. Enyoh, 2021. Anticancer activity of Nigerian medicinal plants: a review. Future J. Pharm. Sci., Vol. 7. 10.1186/s43094-021-00222-6.
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  2. Ohiagu, F.O., P.C. Chikezie and C.M. Chikezie, 2021. Sickle hemoglobin polymerization and antisickling medicinal plants. J. Phytopharmacol., 10.31254/phyto.2021.10209.
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  3. Ohiagu, F.O., P.C. Chikezie and C.M. Chikezie, 2021. Pathophysiology of diabetes mellitus complications: metabolic events and control. Biomed. Res. Ther., 8: 4243-4257.
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  4. Ohiagu, F.O., K.C. Lele, P.C. Chikezie, A.W. Verla and C.E. Enyoh, 2020. Pollution profile and ecological risk assessment of heavy metals from dumpsites in onne, rivers state, Nigeria. Chem. Africa, 10.1007/s42250-020-00198-5.
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  5. Ohiagu, F.O., K.C. Lele, P.C. Chikezie, A.W. Verla and C.E. Enyoh, 2020. Bioaccumulation and health risk assessment of heavy metals in Musa paradisiaca, Zea mays, Cucumeropsis manii and Manihot esculenta cultivated in Onne, rivers state, Nigeria. Environ. Anal. Health Toxicol., 10.5620/eaht.e2020011.
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  6. Chukwunyere, E.K., P.C. Chikezie, P.C. Anuforo, J. Adejor and H.C. Nwankwo, 2020. Effects of aqueous extract of Terminalia catappa L. on membrane stability of sickle cell erythrocytes. Int. Blood Res. Rev., 11: 13-19.
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  7. Chikezie, P.C., R.C. Ekeanyanwu and A.B. Chile-Agada, 2020. Polymerization of deoxygenated sickle hemoglobin in the presence of fractionated leaf extracts of Anacardium occidentale, Psidium guajava, and Terminalia catappa. Bull Natl. Res. Cent., 10.1186/s42269-020-00392-y.
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  8. Chikezie, P.C., R.C. Ekeanyanwu and A.B. Chile-Agada, 2020. Phytocomponents from Anacardium occidentale, Psidium guajava, and Terminalia catappa altered membrane osmotic stability of sickle erythrocytes. Beni-Suef Univ. J. Basic Appl. Sci., 10.1186/s43088-019-0030-z.
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  9. Chikezie, P.C., R.C. Ekeanyanwu and A.B. Chile-Agada, 2020. Phytocomponents from Anacardium occidentale, Psidium guajava, and Terminalia catappa altered membrane osmotic stability of sickle erythrocytes. Beni-Suef Univ J Basic Appl Sci., 10.1186/s43088-019-0030-z.
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  10. Chikezie, P.C., R.C. Ekeanyanwu and A.B. Chile-Agad, 2020. GC-MS and FT-IR analyses of phytocomponents from petroleum ether fraction of leaf extract of Psidium guajava. Res. J. Med. Plants 13: 26-31.
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  11. Chikezie, P.C., F.O. Ohiagu, V.N. Ikonne and V.U. Ekeocha, 2020. Acute dysfunctional status of hepatorenal tissues of rats administered with leaf extracts of Ocimum gratissimum L. (Lamiaceae). Biomed. Res. Ther., 7: 3602-3613.
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  12. Obasi, E., K. Iheanacho, N. Nwachukwu, N. Agha and P.C. Chikezie, 2019. Evaluation of body weight, serum glucose level and oxidative stress parameters of diabetic rats administered phenolic aqueous leaf extract of Vitex doniana. Biomed. Res. Ther., 6: 3359-3367.
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  13. Nwankpa, P., C.C. Etteh, C.N. Ekweogu, P.C. Chikezie, O.G. Chukwuemeka and J.N. Egwurugwu, 2018. Effect of ethanol root and leave extracts of sida acuta on some kidney function indices and electrolytes in albino wistar rats. Int. J. Curr. Microbiol. Appl. Sci., 7: 2759-2766.
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  14. Chikezie, P.C., 2018. Changes in hepato-renal tissues biomarkers of alloxan-induced diabetic wistar rats co-administered monosodium glutamate and ascorbic acid. MOJ Food Process. Technol., 6: 312-317.
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  15. Chikezie, C.M., O.A. Ojiako, A.A. Emejulu and P.C. Chikezie, 2018. Atherogenicity of diabetic rats administered single and combinatorial herbal extracts. Bull. Faculty Pharm. Cairo Univ., 56: 169-174.
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  16. Wood, A.J., K. McManus, M.H. Wright, A.C. Greene and I.E. Cock, 2017. Growth inhibitory activity of selected Australian syzygium species against malodour forming bacteria. Pharmacogn. Commun. 7: 129-136.
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  17. Ojiako, O.A., P.C. Chikezie, D.I. Ukairo, C.O. Ibegbulem and R.N. Nwaoguikpe, 2017. Functional assessments and histopathology of hepatorenal tissues of wistar rats infused with carbon tetrachloride and treated with raw and hydrothermal processed herbs. Pharmacogn. Commun., 7: 142-151.
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  18. Ojiako, O., P. Chikezie, D. Ukairo, C. Ibegbulem and R. Nwaoguikpe, 2017. Radical scavenging potential: antioxidant vitamins and total phenolics contents of raw and hydrothermal processed herbs in vitro. J. Exp. Integr. Med., Vol. 6. 10.5455/jeim.191016.or.162.
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  19. Ojiako, O., P. Chikezie, D. Ukairo, C. Ibegbulem and R. Nwaoguikpe, 2017. Radical scavenging potential: Antioxidant vitamins and total phenolics contents of raw and hydrothermal processed herbs In vitro. J. Exp. Integr. Med., 10.5455/jeim.191016.or.162.
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  20. Ibegbulem, C.O., A.I. Ukoha, P.C. Chikezie and C.N. Opara, 2016. Acute blood steroidal sex hormone levels and lipid profile, erythrocyte antioxidant enzymes activities and organ weights of Wistar rats fed with monosodium glutamate-containing diet. J. Acute Dis., .
  21. Ibegbulem, C.O., A.C. Ene, P. Nwanpka, P.C. Chikezie and C.U. Igwe, 2016. Effect of wood charcoal on rate of microbial production of lactic acid in dehulled and undehulled Vigna unguiculata pastes. Afr. J. Microbiol. Res., .
  22. Ibegbulem, C.O. and P.C. Chikezie, 2016. Levels of acute blood indices disarrangement and organ weights of Wistar rats fed with flavour enhancer- and contraceptive-containing diets. J. Invest. Biochem., .
  23. Ibegbulem, C.O. and P.C. Chikezie, 2016. Comparative proximate composition and cyanide content of peeled and unpeeled cassava tubers processed into Garri by traditional methods. Int. Food Res. J., .
  24. Ibegbulem, C. and P. Chikezie, 2016. Levels of acute blood indices disarrangement and organ weights of wistar rats fed with flavour enhancer- and contraceptive-containing diets. J. Invest. Biochem., 10.5455/jib.20160106122902.
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  25. Chikezie, P.C., C.O. Ibegbulem, O.S. Monago, F.N. Mbagwu and C.U. Nwachukwu, 2016. Amino acid profiles, total nitrogen contents, and computed-protein efficiency ratios of Manihot esculenta root and Dioscorea rotundata tuber peels. J. Food Process., 2016: 1-8.
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  26. Chikezie, P.C., C.O. Ibegbulem, O.S. Monago, F.N. Mbagwu and C.U. Nwachukwu, 2016. Amino acid profiles, total nitrogen contents and computed-protein efficiency ratios of Manihot esculenta root and Dioscorea rotundata tuber peels. Int. Food Res. J., .
  27. Chikezie, P.C., 2016. Membrane lipid peroxidation and redox status of human sickle erythrocytes incubated in leaf extract of Gongronema latifolium. J. Biol. Sci., .
  28. Chikezie, P.C. and C.U. Ekechukwu, 2016. Acute patho-toxicological indicators of methaemoglobinemia. J. Acute Dis., 10.1016/j.joad.2016.03.001.
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  29. Ojiako, O.A., P.C. Chikezie and A.C. Ogbuji, 2015. Radical scavenging potentials of single and combinatorial herbal formulations in vitro. J. Traditional Complementary Med., 6: 153-159.
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  30. Ojiako, O.A., P.C. Chikezie and A.C. Ogbuji, 2015. Blood glucose level and lipid profile of alloxan-induced hyperglycemic rats treated with single and combinatorial herbal formulations. J. Traditional Complementary Med., 6: 184-192.
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  31. Ojiako, O.A., P.C. Chikezie and A.C. Ogbuji, 2015. Antioxidant status of liver and kidney homogenates from hyperglycemic rats administered with single and combinatorial herbal formulations. Free Radicals Antioxid., 5: 13-20.
  32. Ojiako, O.A. and P.C. Chikezie, 2015. Blood Na+/K+ and Cl-Levels of hyperglycemic rats administered with traditional herbal formulations. Pharm. Commun., 5: 140-144.
  33. Ojiako, O.A. and P.C. Chikezie and C.A. Ogbuji, 2015. Glycemic index/renal and hepatic antioxidant status of hyperglycemic rats treated with single and combinatorial herbal formulations. J. Diabetes Metab., .
  34. Ibegbulem, C.O., P.C. Chikezie, and E.C. Dike, 2015. Growth rate, haematologic and atherogenic indicators of Wistar rats fed with cocoa beverages. J. Mol. Pathophysiology, 4: 77-84.
  35. Ibegbulem, C.O., P.C. Chikezie, and E.C. Dike, 2015. Functional assessments and histopathology of renal and hepatic tissues of Wistar rats fed with cocoa containing diets. J. Nutr. Food Sci., .
  36. Ibegbulem, C.O., P.C. Chikezie and E.C. Dike, 2015. Pathological research and acute hepatic and renal tissue damage in Wistar rats induced by cocoa. J. Acute Dis., 5: 51-58.
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  37. Chikezie, P.C., O.A. Ojiako and K.C. Nwufo, 2015. Overview of anti-diabetic medicinal plants: the nigerian research experience. J. Diabetes Metab., Vol. 6, No. 6. 10.4172/2155-6156.1000546.
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  38. Chikezie, P.C., C.O. Ibegbulem and F.N. Mbagwu, 2015. Bioactive principles from medicinal plants. Res. J. Phytochem., 9: 88-115.
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  39. Chikezie, P.C., 2015. Short-term capacities of ethanolic theobroma cacao bean extract to ameliorate oxidative stress, hyperglycemia, and dyslipidemia in alloxan-induced diabetic rats. J. invest. Biochem., 4: 23-29.
  40. Chikezie, P.C., 2015. Kinetic studies of polyphenol oxidase from white yam (dioscorea rotundata poir) Tuber. J. Nutr. Food Sci., .
  41. Chikezie, P.C., 2015. Histopathological studies of renal and hepatic tissues of hyperglycemic rats administered with traditional herbal formulations. Int. J. Green Pharm., 9: 184-191.
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  42. Chikezie, P.C., 2015. Glutathione S-transferase activity in diagnostic pathology. Metabolomics, Vol. 5. 10.4172/2153-0769.1000153.
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  43. Chikezie, P.C., 2015. Critical roles of thiol-mediated antioxidant detoxification systems in the pathophysiology of Plasmodium falciparum-infected erythrocytes. J. Invest. Biochem., 4: 61-68.
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  44. Chikezie, P.C. and A.O. Ojiaka, C.A. Ogbuji, 2015. Oxidative stress in diabetes mellitus. Int. J. Biol. Chem., .
  45. Chikezie, P.C. and A.O. Ojiaka, C.A. Ogbuji, 2015. Comparative hypoglycemic activities of aqueous and ethanolic extracts of four medicinal plants (Acanthus montanus, Asystasia gangetica, Emilia coccinea and Hibiscus rosasinensis) in Type I diabetic rats. J. Intercultural Ethnopharmacol., 4: 228-233.
  46. Chikezie, P.C. and A.O. Ojiaka, 2015. Herbal medicine: yesterday, today and tomorrow. J. Traditional Complementary Med., .
  47. Ojiako, A.O., P.C. Chikezie and C.A. Ogbuji, 2014. Blood index/histopathological status of renal and hepatic tissues of hyperglycemic rats administered with traditional herbal formulations. J. Phytopharmacol., .
  48. Ojiako, A.O. and P.C. Chikezie, 2014. Comparative proximate composition and hypoglycemic properties of three medicinal plants (Verononia amygdalina, Azadirachta indica and Moringa oleifera). Pharmacog. Commun., 4: 40-48.
  49. Ibegbulem, C.O., K.M.E. Iheanacho, C.U. Igwe and P.C. Chikezie, 2014. Velocity, rates and kinetics of industrial reactions and processes. In: Laboratory Experiments in Biochemistry (A Students' Manual). Ojiako, O.A. (Ed.). Futo Press Ltd., Owerri, Nigeria., pp: 421-428..
  50. Ibegbulem, C.O. and P.C.Chikezie, 2014. Biochemical and sensory indices of Kunu-Zaki beverages produced from sprouted and unsprouted guinea corn and their correlations. Am. J. Food Technol., 9: 56-63.
  51. Chikezie, P.C., 2014. Membrane integrity of two human erythrocyte genotypes in the presence of the aqueous solution of sodium metabisulphite and their correlations in vitro. J. Invest. Biochem., 3: 164-169.
  52. Chikezie, P.C., 2014. Glutathione S-Transferase activity of three erythrocyte genotypes of human participants treated with pyrimethamine/sulphadoxine and quinine. Global J. Med. Res., 14: 5-12.
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  53. Chikezie, P.C., 2014. Comparative erythrocyte glutathione s-transferase activity profile of non-malarious guinea pigs (cavia tschudii) administered pyrimethamine/sulfadoxine and artemether/lumefantrine combination therapies. Asian J. Biochem., 9: 203-212.
  54. Chikezie, P.C. and K.M.E. Iheanacho, 2014. Comparative hypoglycemic property of aqueous and ethanolic extracts of viscum album (Mistletoe) and their effects on body and organ weights of diabetic rats (Rattus norvegicus). Phram. Commun., 4: 13-19.
  55. Chikezie, P.C. and A.A. Uwakwe, 2014. Activities of three erythrocyte enzymes of hyperglycemic rats (Rattus norvegicus) treated with Allium sativa extract. J. Diabetes Metab. Disorders, .
  56. Chidoka, C.P. and U.A. Amadikwa, 2014. Protective effect of allium sativa extract against carbon tetrachloride-induced hepatic oxidative stress and hyperlipidemia in rats. Afr. J. Biotechnol., 13: 1671-1678.
  57. C.O. Ibegbulem, P.C. Chikezie, C.O. Nweke, C.E. Nwanyanwu, D.C. Belonwu 2014. Effects of Processing Pineapple-Based Must into Wines by Anaerobic Fermentation Am. J. Food Technol., 9: 162-171.
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  58. Belonwu, D.C., C.O. Ibegbulem, M.N. Nwokocha and P.C. Chikezie, 2014. Some phytochemicals and hydrophilic vitamins of Anacardium occidentale. Res. J. Phytochem., 8: 78-91.
  59. Belonwu, D.C., C.O. Ibegbulem and P.C. Chikezie, 2014. Systemic evaluation of antibacterial activity of Anacardium occidentale. J. Phytopharmacol., 3: 193-199.
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  60. Alisi, C.S. and P.C. Chikezie, 2014. Assessment of air quality and erythrocyte oxidative stress indicators of storekeepers of laboratory/industrial chemicals in owerri, Imo state, Nigeria. Imo State, Nigeria. Free Radicals Antioxid., 4: 67-69.
  61. Ojiako, A.O., P.C. Chikezie and U.C. Zedech, 2013. Serum lipid profile of hyperlipidemic rabbits (Lepus townsendii) treated with leaf extracts of hibiscus rose-sinesis, emilia coccinea, acanthus montanus and asystasia gangetica. J. Med. Plants Res., 7: 3226-3231.
  62. Njoku, V.O., P.C. Chikezie and A.M. Kaoje, 2013. Kinetic studies of alkaline phosphatase extracted from rabbit (Lepus townsendii) liver. Afr. J. Biotechnol., 10: 3157-3162.
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  63. Chikezie, P.C., and R.T. Okpara, 2013. Serum lipid profile and hepatic dysfunction in moderate plasmodium falciparum infection. J. Public Health Epidemiol., 5: 379-384.
  64. Chikezie, P.C., A.R. Akuwudike, C.M. Chikezie and C.O. Ibegbulem, 2013. Fractional purification and kinetic parameters (Km and Vmax) of polyphenol oxidase extracted from three segments of Solanum melongenas and Musa sapietum fruits. Am. J. Plant Physiol., 8: 63-73.
  65. Chikezie, P.C., A.R. Akuwudike and C.M. Chikezie, 2013. Thermal and pH stabilities of polyphenol oxidase extracted from solanum melongenas and musa sapientum fruits. Afr. J. Biotechnol., 12: 5688-5694.
  66. Chikezie, P.C., A.R. Akuwudike and C.M. Chikezie, 2013. Polymerization studies of sickle cell hemoglobin incubated in aqueous leaf extract of nicotiana tabacum product. Res. J. Med. Plant, 7: 92-99.
  67. Chikezie, P.C. and R.T. Okpara, 2013. Haematologic and biochemical indices of Plasmodium falciparum infected inhabitants of Owerri, Imo State, Nigeria. J. Med. Lab. Diagn., 4: 38-44.
  68. Chikezie, P.C. and O.A. Ojiako, 2013. Cyanide and aflatoxin loads of processed cassava (Manihot esculenta) tubers (Garri) in Njaba, Imo state, Nigeria. Toxicol. Int., 20: 261-267.
  69. Chikezie, P., A. Akuwudike and F. Chilaka, 2013. Absorption spectra of normal adults and patients with sickle cell anaemia haemoglobins treated with hydrogen peroxide at two pH values. Iran. J. Blood Cancer, 5: 129-135.
  70. Ibegbulem, C.O., L.A. Nwaogu, C.S. Alisi, C.U. Igwe, G.E. Egbung, P.C. Chikezie, 2012. Anti-aggregation effects of processed yellow and white garri aqueous filtrates on sickle cell trait haemoglobin. J. Res. Biochem., 4: 47-52.
  71. Ibegbulem, C.O. and P.C. Chikezie, 2012. Serum lipid profile of rats (Rattus norvegicus) fed with palm oil and palm kernel oil-containing diets. Asian. J. Biochem., 7: 46-53.
  72. Ibegbulem, C.O. and P.C. Chikezie, 2012. Hypoglycemic properties of ethanolic extracts of Gongronema latifolium, Aloe perryi, Viscum album and Allium sativum administered to alloxan-induced diabetic albino rats (Rattus norvegicus). Pharm. Commun., 3: 12-16.
  73. Chikezie, P.C., A.R. Akuwudike and C.M. Chikezie, 2012. Membrane stability and methaemoglobin content of human erythrocytes incubated in aqueous leaf extract of Nicotiana tabacum product. Free Radicals Antioxid., 2: 56-61.
  74. Chikezie, P.C., 2011. Sodium metabisulfite-induced polymerization of sickle cell hemoglobin incubated in the extracts of three medicinal plants (Anacardium occidentale, Psidium guajava, and Terminalia catappa). Pharmacogn. Mag., 7: 126-132.
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  75. Chikezie, P.C., 2011. Oxidative stress indicators of human sickle erythrocytes incubated in aqueous extracts of three medicinal plants. Asian J. Biochem., 6: 373-383.
  76. Chikezie, P.C., 2011. Methaemoglobin concentration and NADH-methaemoglobin reductaseactivity of three human erythrocyte genotypes. Asian J. Biochem., 6: 98-103.
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  77. Chikezie, P.C., 2011. Glutathione S-transferase activity of human erythrocytes incubated in aqueous solutions of five antimalarial drugs. Free Radicals Antioxid., 1: 26-30.
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  78. Chikezie, P.C., 2011. Comparative in vitro osmotic stability of three human erythrocyte genotypes in the presence of quinine and chloroquine phosphate. Asian J. Biochem., 6: 55-64.
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  79. Chikezie, P.C. and A.A. Uwakwe, 2011. Membrane stability of sickle erythrocytes incubated in extracts of three medicinal plants: Anacardium occidentale, Psidium guajava and Terminalia catappa. Pharm. Mag., 7: 121-125.
    CrossRef  |  PubMed  |  
  80. Chikezie, P.C. and A.A. Uwakwe, 2011. Membrane lipid peroxidation of hbaa erythrocyte of non-malarious participants administered with quinine. Free Radicals Antioxid., 1: 21-25.
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  81. Chikezie, P.C., C.M. Chikezie and P.I. Amaragbulem, 2010. Effect of antimalarial drugs on polymerization of sickle cell hemoglobin (HbS). Turk. J. Biochem., 35: 41-44.
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  82. Chikezie, P.C., A.A. Uwakwe and C.C. Monago, 2010. Comparative osmotic fragility of three erythrocyte genotypes (HbAA, HbAS and HbSS) of male subjects/volunteers administered with five antimalarial drugs. Afr. J. Biochem. Res., 4: 57-64.
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  83. Chikezie, P.C., C.M. Chikezie, A.A. Uwakwe and C.C. Monago, 2009. Investigation on the methaemoglobin concentration of three human erythrocyte genotypes infected with Plasmodium falciparum. J. Appl. Sci. Environ. Manage., 13: 5-8.
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  84. Chikezie, P.C., C.M. Chikezie, A.A. Uwakwe and C.C. Monago, 2009. Comparative study of glutathione S-transferase activity of three human erythrocyte genotypes infected with plasmodium falciparum. J. Appl. Sci. Environ. Manage., 13: 13-18.
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  85. Chikezie, P.C., C.C. Monago and A. Uwakwe, 2009. Studies of methemoglobin concentrations of three human erythrocyte genotypes (Hb AA, Hb AS and Hb SS) in the presence of five anti-malarial drugs. Iran. J. Blood Cancer, 1: 151-157.
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  86. Chikezie, P.C., A.A. Uwakwe and C.C. Monago, 2009. Studies of human HbAA erythrocyte osmotic fragility index of non malarious blood in the presence of five antimalarial drugs. J. Cell Anim. Biol., 3: 39-43.
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  87. Chikezie, P.C., A.A. Uwakwe and C.C. Monago, 2009. Glutathione S-transferase activity of erythrocyte genotypes HbAA, HbAS and HbSS in male volunteers administered with Fansidar and Quinine. Afr. J. Biochem. Res., 3: 210-214.
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  88. Chikezie, P.C., A.A. Uwakwe and C.C. Monago, 2009. Erythrocyte glutathione S-transferase activity in human administered with five antimalarial drugs. J. Pharm. Allied Sci., 6: 112-116.
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  89. Chikezie, P.C., A.A. Uwakwe and C.C. Monago, 2009. Erythrocyte glutathione S-Transferase activity in human administered with five antimalarial drugs. J. Pharm. Allied Sci., Vol. 6. 10.4314/jophas.v6i3.48543.
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  90. Chikezie, P.C., 2009. Comparative methaemoglobin concentrations of three erythrocyte genotypes (HbAA, HbAS and HbSS) of male participants administered with five antimalarial drugs. Afr. J. Biochem. Res., 3: 266-271.
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  91. Chikezie, P.C., I.R. Keke, A.A. Uwakwe and C. Monago, 2008. In vitro studies of human erythrocyte glutathione-S transferase activity in the presence of five antimalarial drugs. Int. Sci. Res. J., 1: 103-106.
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  92. Chikezie, P.C., 2008. Extraction and activity of polyphenol oxidase from kolanuts (Cola nitida and Cola acuminata) and cocoa (Theobroma cacao). J. Agric. Food Sci., 4: 115-124.
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  93. Chikezie, C.M. and P.C. Chikezie, 2008. Comparative osmotic fragility of three human erythrocyte genotypes infected with Plasmodium falciparum. J. Biol. Environ. Sci., 2: 58-62.
  94. Chikezies, P.C., C.M. Chikezie and C.O. Nwanegwo, 2007. Osmotic fragility index of chicken (Gallus gallus) and human HbAA erythrocytes. Int. Sci. Res. J., 1: 1-5.
  95. Chikezie, P.C., B.A. Amadi and C.M. Chikezie, 2007. Evaluation of two polyphenoloxidase kinetic parameters at three stages of Musa sapietum fruit maturation. Inter. J. Agric. Food Sys., 1: 63-67.
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  96. Chikezie, P.C., 2007. The effects of pyrimethamine and sulphadoxine mixture on plasma haemoglobin/ methaemoglobin ratio of Hbaa erythrocytes. Int. J. Nat. Appl. Sci., 3: 116-121.
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  97. Chikezie, P.C., 2007. Osmotic fragility index of HBAA red blood cells in the presence of aqueous extracts of three medicinal plants (Aframomum melegueta, Garcina kola and Cymbopogon citracus). Global J. Pure Appl. Sci., 13: 497-499.
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  98. Chikezie, P.C., 2007. Effect of ethanolic extracts of Garcina kola, Cola nitida and Cola acuminata on in vitro hemoglobin s polymerization. Int. J. Trop. Agric. Food Syst., 1: 220-225.
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  99. Chikezie, P.C., 2007. Effect of cinnamic acid on polyphenoloxidase activity of dioscorea rotundata. Global J. Pure Appl. Sci., 13: 387-389.
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  100. Chikezie, P.C., and A.R. Akuwudike, 2006. Comparative in vitro effect of ethanolic extracts of Cola nitida and Cola acuminata on plasma levels of methaemoglobin of HbAA erythrocytes. J. Biol. Environ. Sci., 1: 34-38.
  101. Chikezie, P.C., 2006. Studies on the anti-sickling effects of Azadirachta indica and Vernonia amygdalina on HbSS erythrocytes. Int. J. Nat. Appl. Sci., 2: 24-28.
    CrossRef  |  Direct Link  |  
  102. Chikezie, P.C., 2006. Effect of phenacetin on NADH - methaemoglobin reductase of human erythrocytes. Global J. Pure Appl. Sci., 12: 339-342.
    CrossRef  |  Direct Link  |  
  103. Chikezie, P.C. and V.H.A. Enemor, 2006. Effect of experimental quinine administration on plasma levels of hemoglobin and methemoglobin in guinea pig. Int. J. Nat. Appl. Sci., 1: 150-152.
    CrossRef  |  Direct Link  |  
  104. Amadi, B.A., P.C. Chikezie and H.C. Okeoma, 2006. Physiochemical characteristics of Nworie river and its effect on liver function on rats. J. Nigeria Environ. Sci., 3: 183-187.
  105. Enemor, V.H.A., J.C. Anosike, B.E.B. Nwoke and P.C. Chikezie, 2005. Serum aminotransferases and bilirubin levels in malaria patients. Int. J. Nat. Applied Sci., 1: 85-89.
    Direct Link  |  
  106. Okogun, G.R.A., P.C. Chikezie, C.M. Nwosu, J.C. Anosike and A.N. Amadi, 2004. Effect of three kola species, Garcina kola, Cola nitida and Cola acuminata on sickling of human erythrocytes. J. Appl. Basic Sci., 2: 47-53.
  107. Chikezie, P.C. and C.O. Ibegbulem, 2004. Effect of quinine on osmotic fragility of HbAA red blood cells of guinea pigs. J. Innov. Life Sci., 8: 5-8.
  108. Chikezie, P.C., 2002. Enzyme Action. In: Basic Biological Laboratory Manual. Keke, I.R., J.C. Uwaezuoke, C.I. Onuoha, F.N. Mbagwu, C.M.U. Ajero and P.C. Chikezie (Ed.). Udebiuwa Press, Owerri, Nigeria., pp: 68-73..
  109. Chikezie, P.C., 2002. Biological Molecules. In: Basic Biology Laboratory Manual. Keke, I.R., J.E. Uwaezuoke, C.I. Onuoha, F.N. Mbagwu, C.M.U. Ajero and P.C. Chikezie (Ed.). Udebiuwa Press, Owerri, Nigeria., pp: 58-67..